#Lyophilization Services for Biopharmaceuticals Market Analysis

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The Lyophilization Services for Biopharmaceuticals Market exploration report is an intelligence report that includes precise and precious data on request size, development countries, request share, and profit vaticinations through 2028.

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Lyophilization Services for Biopharmaceuticals Market

Market Overview

The Global "Lyophilization Services for Biopharmaceuticals Market" is estimated to reach at a high CAGR during the forecast period (2021-2028).

 Lyophilization involves freeze-drying of products. In pharmaceutical industries, this process is widely used to increase the self-life of antibiotics, vaccines, and protein-based drugs. Biopharmaceutical companies are using lyophilization services to keep APIs and drugs sterile.

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 Market Dynamics

The global lyophilization services for biopharmaceuticals market growth is driven by the rising focus on enhanced manufacturing practices are increasing the demand for lyophilization services, rising demand for lyophilized products, and rapid growth in contract manufacturing and lyophilization services worldwide.

 Rapid growth in contract manufacturing and lyophilization services worldwide is expected to drive market growth

 The need to prolong the shelf-life of antibiotics and protein-based drug formulations is a key trend boosting the prospect in the lyophilization services for the biopharmaceuticals market. Notably, there is a persistent need to keep the biological activity of vaccines intact and the shelf-life as high as possible. The growing uptake of these in third-world countries increases the need. Contract manufacturing organizations have also expanded their array of lyophilization services for biopharmaceuticals. This has also expanded the outlook of the lyophilization services for the biopharmaceuticals market.

 In addition, technological advancements in cGMP lyophilizers have led them to assess cutting-edge lyophilizers at a cost-effective rate. The uptake in the lyophilization services for the biopharmaceuticals market has been underpinned by the rapid pace of the rising demand for biological therapies for disease therapeutics in developed and developing regions. Over the past few years, the need to improve the shelf-life and efficacy of biologics has increased in emerging markets for the biopharmaceutical industry. The drive stems from the need for novel formulations for biologics in developed countries. This has propelled the demand for lyophilization services on a contract basis. Automation in lyophilization has bolstered the demands for topical and injectable ophthalmics services over the past recent years.

 Few challenges associated with the lyophilization process is likely to hamper the market growth

 However, the market is likely to hinder due to the challenges associated with the lyophilization process, such as leakage during filling; the lyophilization process requires placing material in reusable containers, which require rigorous cleaning before the next batch is added. But, despite new technologies, equipment, and instrumentation, such as condensers that can handle high-vapor loads, lyophilization remains time-consuming and, as such, a costly process for developing APIs and medical polymers. Hence, these factors are likely to restrain the market growth.

 COVID-19 Impact Analysis

With the outbreak of COVID-19, the healthcare sector is adopting new technology that can help hospitals overcome the current pandemic and future medical emergencies. Owing to the growing adoption of new tools and technologies, the global Lyophilization Services for Biopharmaceuticals market is projected to grow substantially during the coming years. COVID-19 has become a global pandemic and consumed more than a million lives. This has stimulated healthcare companies are developing innovative tools and technologies that can help doctors and medical officers to overcome present and future medical emergencies. For instance, In February 2021, Rentschler Biopharma; Germany-based contract development and manufacturing organization (CDMO) announced to start commercial manufacture, formulation, and downstream processing of CVnCoV COVID-19 candidate vaccine by CureVac. Similarly, Bayer also announced to manufacture 160 million doses of CVnCoV in 2022. Owing to this, the global Lyophilization Services for Biopharmaceuticals market is projected to grow exponentially in the coming years.

 Segment Analysis

The freeze-drying analytical services segment is expected to hold the largest share in this market segment

 Lyophilization services preserve various food products, such as fruits and vegetables, meat, fish, herbs and food flavorings, ice creams, and coffee. Freeze-dried foods do not need to be refrigerated or preserved with chemicals and can be reconstituted quickly and easily by adding water. Another major advantage of freeze-drying services is their ability to produce clean, whole, and nutritious food ingredients with a highly prolonged shelf life (making food products versatile and accessible).

 The use of freeze-dried foods is increasing for astronauts and military personnel, as conventional drying methods have major disadvantages. For instance, high temperatures can cause chemical or physical changes in food products, and their overall quality is not on par with freeze-dried food products. Considering these advantages, the use of freeze-drying analytical services as a food preservation technique is increasing across the globe.

 Geographical Analysis

North America region holds the largest market share of global lyophilization services for the biopharmaceuticals market

 North America is projected to dominate the global lyophilization services for biopharmaceuticals market and accounts for the largest share during the forecast period owing to an increasing number of strategic mergers and acquisitions among players regarding biopharmaceutical stabilization. For instance, in recent times, many players have leveraged the potential of partnership to expand their new fill and finish equipment for sterile processing packaging. A case in point is West Pharmaceutical Services, Inc., a company that says it pioneers in injectable drug administration solutions, entering into a partnership with SCHOTT. The agreement will combine the Ready Pack system of the former with the glass vials platform of the later, notably its high-quality RTU glass vials. Numerous such players are aiming to meet the customization needs through partnerships. Key players in the North American lyophilization service markets are Anteco Pharma LLC, Axcellerate Pharma LLC, Berkshire Sterile Manufacturing, Inc., Jubilant HollisterStier LLC, Lyophilization Technology, Inc. (LTI). These factors are propelling the growth of the lyophilization services for the biopharmaceuticals market in North America.

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 Competitive Landscape

The global lyophilization services for the biopharmaceuticals market is highly competitive with the presence of local as well as global companies. Some of the key players which are contributing to the growth of the market include ATTWILL Medical Solutions; Axcellerate Pharma LLC.; AB BioTechnologies, Inc.; Berkshire Sterile Manufacturing, Inc.; Emergent BioSolutions; LSNE Contract Manufacturing; Lyophilization Technology, Inc.; Jubilant HollisterStier LLC; Biofortuna Ltd; and GILYOS GmbH. The major players are adopting several growth strategies such as product launches, acquisitions, and collaborations, which are contributing to the growth of the market globally. For instance, In February 2020, Grand River Aseptic Manufacturing (GRAM), a contract development and manufacturing organization, completed its US$60 million expansion project and recently took occupancy with the opening of its large-scale fill/finish facility with this expansion.

 Global Lyophilization Services for Biopharmaceuticals Market – Key Companies to Watch

Biofortuna Ltd

 Overview: Biofortuna is a specialist contract development and manufacturing organisation providing Genomic services, custom development, and manufacturing support. Its service portfolio includes custom development, laboratory services, freeze-drying (lyophilisation), contract manufacturing and dispensing, and kitting.

 Product Portfolio: It provides products like SSPGo HLA typing Freeze-Drying- SSPGo is the ONLY single step ‘off the shelf’ SSP solution. The world’s first freeze-dried (lyophilised) HLA SSP delivers unique simplicity, accuracy, and ease of use.

 Key Developments: In June 2020, Biofortuna has provided assay development and manufacturing support to QuantuMDx Group Limited to assist in the manufacturing scale-up, regulatory approval, and launch of their rapid, sensitive SARS-CoV-2 test.

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Global Dual Chamber Syringe (DCS) Filling Machine Market Growth Statistics to Make Multi-Billion Dollar Market during 2021-2028

Overview of Global Dual Chamber Syringe (DCS) Filling Machine Market:

The world class Dual Chamber Syringe (DCS) Filling Machine Market report has an evaluation of the factors influencing the supply and demand of the related products and services, and challenges reckoned by Market players. The report begins with a Market outlook together with the data integration and capabilities study with the appropriate findings. It has projected strong upcoming growth of the Market. This large scale Marketing report aids to establish correlative relationship between the product brand and consumers’ needs and preferences. Further, manufacturer can adjust production according to the conditions of demand which are analysed in the winning Dual Chamber Syringe (DCS) Filling Machine report.

Dual Chamber Syringe (DCS) Filling Machine Market survey report combines secondary research which includes reference to different statistical databases, related patent and regulatory bibliography and a number of internal and external proprietary information. With the help of key information and Market insights from technical and marketing experts, the report offers an objective estimation of the Dual Chamber Syringe (DCS) Filling Machine Market. This report makes to focus on the more important aspects of the Market like what the Market recent trends are. The Market study provides details of drivers and restraints for the Dual Chamber Syringe (DCS) Filling Machine Market with the help of SWOT analysis, along with the impact they have on demand over the forecast period.

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The Global Dual Chamber Syringe (DCS) Filling Machine Market is expected to grow with the CAGR of 8.02% in the forecast period of 2021 to 2028.

According to the market report analysis, Dual-Chamber Syringe (DCS) Filling Machine is a device used for filling double-chamber syringes. The DCS machines are designed for filling dual chamber prefilled syringes with a combination of drugs which can either be liquid or powder. These machines are widely used by industrial pharmacy and hospital pharmacy.

The most significant key factors driving the growth of the Global Dual Chamber Syringe (DCS) Filling Machine Market are rapid technological advancements in filling machines, rise in biopharmaceutical industry and high investments by prefilled syringe manufacturers, improving filling machine technology and increase in the production of lyophilized drugs.

Top Leading Key Manufacturers are: Syntegon Technology GmbH, MAQUINARIA INDUSTRIAL DARA, SL, TurboFil Packaging Machines, LLC, Wenzhou Zungwan Intelligent Machine Co.,Ltd., OPTIMA packaging group GmbH, MUTUAL CORPORATION, AST, Vanrx Pharmasystems Inc., and Inno4Life. New product launches and continuous technological innovations are the key strategies adopted by the major players.

In terms of the geographic analysis, North America region leads the dual chamber syringe (DCS) filling machine market owing to the rapid technological developments in the syringe filling machines and rise in the number of chronic diseases. APAC is expected to expand at a significant growth rate over the forecast period of 2021 to 2028 because of the rise in health awareness in developing countries high demand for syringe filling machines and significant medical device manufacturing capacity.

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2021-2026 Lyophilization Services for Biopharmaceuticals Market Report | Analysis, Modeling, Risk Factors, Growth Strategies, Drivers, Dynamics, Forecast and more

2021-2026 Lyophilization Services for Biopharmaceuticals Market Report | Analysis, Modeling, Risk Factors, Growth Strategies, Drivers, Dynamics, Forecast and more

A research assessment conducted to provide a thorough analysis of the Lyophilization Services for Biopharmaceuticals Market and different parts of the market mostly envelops the market dynamics stating the complete market segment starting the market size and share worldwide defined and the Lyophilization Services for Biopharmaceuticals market circumstance including the sales and marketing…

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BIOPHARMACEUTICAL STABILIZATION (LYOPHILIZATION) SERVICE MARKET

Biopharmaceutical stabilization or lyophilisation or freeze drying is a process in which water is removed from a product after it is frozen and placed under a vacuum, allowing the ice to change directly from solid form to vapour form without passing through liquid state. The process consists of three separate, unique, and different phases; freezing, primary drying (sublimation), and secondary drying (desorption).

Lyophilization is an advanced technique and is useful in various pharmaceutical sectors. Some advantages of lyophilization are enhanced stability of powders, removal of water without excess heating of product, enhanced product stability in dry state, easy processing of liquid which ensures easy aseptic handling. Some of major disadvantages are higher handling and time and need for sterile diluents for reconstitution and high cost.

Global Biopharmaceutical Stabilization (Lyophilization) Service Market – Drivers

Applications of biopharmaceutical stabilisation have impacted the pharmaceutical and bio-pharmaceutical market owing to the former’s stability characteristics and effective procedures. For instance, in 2015, Stirling, U.K – STERILE manufacturing specialist and symbiosis pharmaceutical service, unveiled a new bulk lyophilization (freeze drying) service. The Scotland-based contract manufacturing organisation (CMO) is supporting clients in the U.S., Europe, and Asia to assist with the manufacture of bulk intermediates and APIs by lyophilization. Moreover, in April 2018, Lyophilization Service of New England (LSNE) acquired an aseptic fill/finish manufacturing facility of PSC Biotech Pomona, U.S. This acquisition has helped the expansion of manufacturing capacity and services of the organization.  Biopharmaceutical stabilisation (lyophilisation) used in pharmaceutical injectable products, vaccines, antibodies, and food products provide parallel growth to the lyophilisation services market which is involved in lyophilizing the products. Lyophilization service can protect the biological activity, extend the shelf life of drugs and increase the dosing precision for each product. These factors are expected to drive global biopharmaceutical stabilization market growth during the forecast period.

Global Biopharmaceutical Stabilization (Lyophilization) Service Market – Impact of COVID-19

Service Providers in lyophilization service markets are expected to see witness an increase in demand , mostly for research and development of pandemic vaccines - or therapeutics. Many suppliers are have begun to addressing this increase in demand, and projected demand by accelerating their research activities . Manufacturers are expected to keep focusing on existing pipeline projects in addition to adding more pandemic- and infectious disease-related drugs and therapies related to pandemic and infectious disease in R&D. So Therefore, current pipelines are not expected to change in the near-term. The impact of COVID-19 on the global biopharmaceutical stabilization (lyophilization) service market has affected every market around the globe in a negative way. As the world is still struggling to recover from the COVID-19 situation it may take a long time in recovery of global biopharmaceutical stabilization market.

Global Biopharmaceutical Stabilization (Lyophilization) Service Market – Restraints

Biopharmaceutical stabilization (Lyophilization) has few demerits as lyophilization includes heating of the product which can cause melt-back and collapse. Moreover, freezing of products is a process in lyophilisation where some microbes have the ability to sustain cold temperature which can cause contamination of products. Moreover, factors such as vapour choking and instability in form of freeze dried cakes is expected to restrain the market growth.

Global Biopharmaceutical Stabilization (Lyophilization) Service Market – Regional Analysis

On the basis of region, the global biopharmaceutical stabilization (lyophilization) service market is segmented into North America, Latin America, Europe, Asia Pacific, Middle East, and Africa. North America is projected to dominate the global biopharmaceutical stabilization (lyophilization) service market and account for the largest share during forecast period owing to an increasing number of strategic mergers and acquisitions among players with regards to biopharmaceutical stabilization. For instance, in 2012, Anteco Pharma is a leader in lyophilization and freeze drying solutions for the specialty food, pharmaceutical industry, expanded its territory through a 25,000-square-foot addition to its manufacturing facility in Lodi, Wis, U.S.. This expansion is focused on manufacture of pharmaceutical and medical devices. Key players in the North America lyophilisation service markets are Anteco Pharma LLC, Axcellerate Pharma LLC, Berkshire Sterile Manufacturing, Inc., Jubilant HollisterStier LLC, Lyophilization Technology, Inc. (LTI). These factors are propelling the growth of biopharmaceutical stabilization (Lyophilization) service market in North America.

Moreover, Key players in the Europe lyophilisation service market are GILYOS GmbH, Lyophilization Services of New England, Inc., and others. Europe is projected to witness sustainable growth in the global biopharmaceutical stabilisation (lyophilisation) service market during the forecast period. For instance, in February 2020, Lyophilization Services of New England (LSNE) Contract Manufacturing, a contract development and manufacturing organization, expanded its company through a 26,000 square foot addition to its existing seven commerce facilities in Bedford, New Hampshire campus, U.S. This expansion has further increased LSNE's commercial drug product manufacturing capacity. The addition will feature a high-speed six head Bausch+Ströbel aseptic vial filling line, Ziel isolator, and multiple large-scale commercial freeze-dryers with automated loading/unloading. These factors are propelling the growth of biopharmaceutical stabilization (Lyophilization) service market in Europe.

Furthermore, the market in Asia Pacific particularly in India and China are expected to contribute significantly to the growth of the global lyophilization services market due to the growing number of contract manufacturing units. Countries such as India, China, and South Korea are two of the biggest countries operating in the market with high expectancy to dominate biopharmaceutical stabilization market in Asia pacific. For instance, in South Korea according to Korea Biomedical Review in 2020, Samsung Biologics said that it has signed a letter of intent for a contract manufacturing organization (CMO) deal worth 381 billion won (US$317.1 million) with a European client. The company said it would disclose its European client's name after Dec. 31, 2023, due to confidentiality reasons. Samsung Biologics plans to produce the client’s biopharmaceutical products at its third plant in Songdo, an international business zone in the western port city of Incheon, South Korea. Key players in Asia Pacific are Piramal Pharma Solutions Inc. and Dr Reddy's Laboratories. These factors are propelling the growth of the biopharmaceutical stabilization (Lyophilization) service market in Asia Pacific.

Global Biopharmaceutical Stabilization (Lyophilization) Service Market – Competitive Landscape

Key players operating in global biopharmaceutical stabilization (Lyophilization) service market are CNS Pharmaceuticals, Jubilant HollisterStier LLC, Lyophilization Technology, Inc. (LTI), GILYOS GmbH, Lyophilization Services of New England, Inc., Piramal Pharma Solutions Inc., Symbiosis Pharmaceutical Services, Millrock Technology, Inc.,  Goodwin Biotechnology Inc.,  Celsus Laboratories Inc. and MME Group Inc.

Key Developments –

1.    In 2015, Stirling, UK – STERILE manufacturing specialist and Symbiosis Pharmaceutical Service, unveiled a new bulk lyophilisation (freeze drying) service. The Scotland-based contract manufacturing organisation, is supporting clients in the U.S., Europe, and Asia to assist with the manufacture of bulk intermediates and APIs by lyophilisation.

2.    In 2019, Lyophilization Services of New England (LSNE), a leading contract development and manufacturing organization (CDMO), announced the acquisition of a sterile injectables manufacturing facility located in León, Spain. The site, LSNE-León, will complement LSNE's existing full-service manufacturing capabilities and expand its presence into Europe.

3.    In February 2020, Grand River Aseptic Manufacturing (GRAM), a contract development and manufacturing organization, completed its US$60 million expansion project and recently took occupancy with the opening of its large-scale fill/finish facility with this expansion

 Global Biopharmaceutical Stabilization (Lyophilization) Service Market – Taxonomy

 By Service

o    Cycle development

o    Aseptic filling

 ·         By Application

o    Antibiotic

o    Antibodies

o    Vaccines

o    Vitamins

o    Hormones

 ·         By End User

o    Pharmaceutical Companies

o    Research Laboratories

o    Others

 ·         By Region

o    North America

o    Latin America

o    Europe

o    Asia Pacific

o    Middle East

o    Africa

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LYOPHILIZED DRUGS MARKET ANALYSIS -(2018-2026)

Lyophilization or freeze drying is the process, in which the water content in the drug sample is frozen, followed by its removal from the sample. In the process of lyophilization, the frozen water content changes directly from solid to vapor without passing through a liquid phase. The process includes three steps: Freezing, primary drying (sublimation), and secondary drying (desorption). Pharmaceutical products that undergo lyophilization process include bulk pharmaceutical/biopharmaceutical ingredient (API), protein, collagen, peptide, oligonucleotide, enzymes, and mAbs.

 Market Dynamics

Lyophilized drugs are majorly used to treat infectious diseases and autoimmune diseases. Thus, increasing prevalence of infectious diseases is expected to aid in growth of the global lyophilized drugs market. For instance, according to The Lancet Infectious Diseases (report) published in 2017, fungal infection affects over a billion people worldwide, resulting in around 11.5 million life-threatening infections and over 1.5 million deaths, annually. The number of lyophilized drugs such as Amphotericin B (Mycoflu), Vonfung NDD (voriconazole,) and other antifungal lyophilized drugs are available in market for treating fungal infections.

Lyophilized drug manufacturers are looking forward to expand their facilities to produce lyophilized drugs on large scale, which in turn contributing to growth of the global lyophilized drugs market. For instance, on January 2017, AB Technologies (AB) announced investment of US$ 10.5 million to build a new 23,000-square-foot manufacturing facility at its site in Bloomington, Indiana. The new facility will include manufacturing area for formulating, filling, lyophilizing, and packaging drugs for early-phase clinical trial studies. Moreover, AB Technologies (AB) added aseptic filling and lyophilizer loading systems into the new facility.

Major pharmaceutical manufacturers are engaged in the development and launching of innovative lyophilized drugs, which is expected to drive the global lyophilized drugs market growth. For instance, in November 2018, Xellia Pharmaceuticals launched Vancomycin Hydrochloride for Injection, USP within the U.S. market. Vancomycin Hydrochloride for Injection is lyophilized powder to treat or prevent infections that are caused by bacteria

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 Key features of the study:

 This report provides in-depth analysis of the global lyophilized drugs market, market size (US$ Mn), and compound annual growth rate (CAGR %) over the forecast period (2018–2026), considering 2017, as the base year

It elucidates potential revenue opportunities across different segments and explains attractive investment proposition matrices for this market

This study also provides key insights about market drivers, restraints, opportunities, new technology launches or approval, market trends, regional outlook, and competitive strategies adopted by the leading players

It profiles leading players in the global lyophilized drugs market based on the following parameters – company overview, financial performance, Technology portfolio, geographical presence, distribution strategies, key developments, and strategies

Key players covered as a part of this study include Sanofi S.A, Merck & Co., Inc., Fresenius Kabi USA, LLC., Ciron Drugs & Pharmaceuticals Pvt Ltd., GlaxoSmithKline plc., Mylan NV., Pfizer, Inc., Amneal Pharmaceuticals LLC, Otsuka Holdings Co., Ltd.  (Otsuka Pharmaceutical Co., Ltd.), and BTG Plc.

Insights from this report would allow marketers and management authorities of companies to make informed decision with respect to their future technology launch, governmental initiatives, technological up-gradation, market expansion, and marketing tactics

The global lyophilized drugs market report caters to various stakeholders in this market, including investors, technology manufacturers, distributors, and suppliers for global Lyophilized Drugs Market, research and consulting firms, new entrants, and financial analysts

Detailed Segmentation:

Global Lyophilized Drugs Market, By Drug Class:

Anti-infective

Antineoplastic

Diuretics

Proton Pump Inhibitor

Anesthetic

Anticoagulant

NSAID’s

Others

Global Lyophilized Drugs Market, By Indication:

Infectious Disease

Autoimmune Disease

Gastrointestinal Disease

Cancer

Others

Global Lyophilized Drugs Market, By Packaging Type:

Vial

Injection

Cartridge

Global Lyophilized Drugs Market, By Region:

North America

Europe

Asia Pacific

Latin America

Middle East

Africa

By Country:

By Drug Class:

By Indication:

By Packaging Type:

U.S.

Canada

Anti-infective

Antineoplastic

Diuretics

Proton Pump Inhibitor

Anesthetic

Anticoagulant

NSAID’s

Others

Infectious Disease

Autoimmune Disease

Gastrointestinal Disease

Cancer

Others

Vial

Injection

Cartridge

By Country:

By Drug Class:

By Indication:

By Packaging Type:

U.K.

Germany

Italy

Spain

France

Russia

Rest of Europe

Anti-infective

Antineoplastic

Diuretics

Proton Pump Inhibitor

Anesthetic

Anticoagulant

NSAID’s

Others

Infectious Disease

Autoimmune Disease

Gastrointestinal Disease

Cancer

Others

Vial

Injection

Cartridge

By Country:

By Drug Class:

By Indication:

By Packaging Type:

Australia

India

China

Japan

ASEAN

South Korea

Rest of Asia Pacific

Anti-infective

Antineoplastic

Diuretics

Proton Pump Inhibitor

Anesthetic

Anticoagulant

NSAID’s

Others

Infectious Disease

Autoimmune Disease

Gastrointestinal Disease

Cancer

Others

Vial

Injection

Cartridge

By Country:

By Drug Class:

By Indication:

By Packaging Type:

Brazil

Mexico

Argentina

Rest of Latin America

Anti-infective

Antineoplastic

Diuretics

Proton Pump Inhibitor

Anesthetic

Anticoagulant

NSAID’s

Others

Infectious Disease

Autoimmune Disease

Gastrointestinal Disease

Cancer

Others

Vial

Injection

Cartridge

By Country/Region:

By Drug Class:

By Indication:

By Packaging Type:

GCC

Israel

Rest of Middle East

Anti-infective

Antineoplastic

Diuretics

Proton Pump Inhibitor

Anesthetic

Anticoagulant

NSAID’s

Others

Infectious Disease

Autoimmune Disease

Gastrointestinal Disease

Cancer

Others

Vial

Injection

Cartridge

By Country/Region:

By Drug Class:

By Indication:

By Packaging Type:

South Africa

Central Africa

North Africa

Anti-infective

Antineoplastic

Diuretics

Proton Pump Inhibitor

Anesthetic

Anticoagulant

NSAID’s

Others

Infectious Disease

Autoimmune Disease

Gastrointestinal Disease

Cancer

Others

Vial

Injection

Cartridge

Company Profiles

Sanofi S.A *

Merck & Co., Inc.

Fresenius Kabi USA, LLC.

Ciron Drugs & Pharmaceuticals Pvt Ltd.

GlaxoSmithKline plc.

Mylan NV.

Pfizer, Inc.

Amneal Pharmaceuticals LLC

Otsuka Holdings Co., Ltd.  (Otsuka Pharmaceutical Co., Ltd.)

BTG Plc.

Company Overview

Technology Portfolio

Financial Performance

Recent Highlights

Strategies

“*” marked represents similar segmentation in other categories in the respective section.

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Country Specific Analysis

Explore CMI Services here

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Address: 1001 4th ave, #3200 Seattle, WA 98154, U.S.

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Email: sales@coherentmarketinsights.com

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The Demand for Medicine Fill Finish Operations

The Demand for Medicine Fill Finish Operations

Error-free fill-finish operations in pharmaceutical and biopharmaceutical manufacturing are crucial to making sure of patient safety. The growing diversity of biologic drugs also has a part in products targeted for parenteral delivery in the demand for aseptic fill-finish operations.

However, to effectively meet this growing demand for fill-finish services requires specialized expertise. This includes appropriate equipment and innovations in both emerging technology and business models.

Fill-Finish Manufacturing

In pharmaceutical manufacturing, fill-finish operations are critical. They are the last step before a product is packaged and delivered to the patient. A drug product is highly valuable at this step. It has been through labor- and cost-intensive production stages. Stages like upstream processing, cell culture or fermentation, and downstream purification.

Failures within the integrity of the fill-finish stage can introduce microbial contamination and generate issues with formulation and dosing. The result could be a loss of valuable products or even potential health risks to patients. Fill-finish operations are the topic of serious scrutiny.

Aseptic Fill-Finish Services and Specialization

Fill-finish requires specialized capabilities and equipment, close coordination, and interaction among personnel, equipment, and facilities. This bears more risks than non-sterile processes. This makes them require more specialization and analysis.

Aseptic fill-finish must be performed during a sterile environment. Expert oversight is also necessary to ensure that the correct method is employed (e.g., steam, dry heat, fumigants, radiation). This is to achieve sterilization without impacting the stability of the drug.

Drug Fill Finish

Lyophilization, or freeze-drying, is often required in the production of stable formulations of parenteral drugs, particularly biologics. The right conditions for lyophilization are an additional technical challenge for manufacturers. This involves complex heat and mass transfer processes.

Growing Demand for Pharmaceutical Fill-Finish Services

Pharmaceutical and biopharmaceutical companies are increasingly relying on contract development and manufacturing operations (CDMOs) to manage their crucial phase of production. Many companies don't possess adequate fill-finish operations for sterile products. Even companies with these capabilities use CDMOs as a backup source for commercial manufacturing.

Sterile fill-finish service providers are responding to the increased demand for capacity and technical expertise, which in many cases exceeds available capacity. Innovations in digitization, integrated IT, automation and environmental conditioning systems are driving this dynamic outsourcing segment.

The broader shift within the pharmaceutical market is creating a requirement for fill-finish operations with flexible capabilities. Fill-finish operations got to remain flexible to stay up with changing, patient-centric demands. This is for brand spanking new drug-delivery systems which will better fit patient lifestyles and increase convenience and adherence.

Pharmaceutical companies with in-house fill-finish operations for clinical trials or commercialization, it's essential to form the best decisions when procuring equipment. The diverse considerations related to sterile fill-finish manufacturing make it especially critical to install the best and most appropriate equipment.

AbbVie Contract Manufacturing provides fill-finish manufacturing using innovative filling line technologies that are specifically built to protect your biologic integrity and optimize your API yield. Our manufacturing optimization meets the needs of your biologic molecules with 100% in-line, constructive weight checking; high-yield process design; dual filling technologies, and advanced cold-chain filling.

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Lyophilization/Freeze Drying Equipment Market - Size, Share, Trends, and Forecast to 2026

Lyophilization/Freeze Drying Equipment Market – Powerful Components of Drug Development & Research

Freeze drying is the removal of ice or other frozen solvents from a material through the process of sublimation and the removal of bound water molecules through the process of desorption. It is an excellent method of preserving a wide variety of heat-sensitive materials such as proteins, microbes, pharmaceuticals, tissues, and plasma. Lyophilization is also used in the biotechnology and biomedical industries to preserve vaccines, blood samples, purified proteins, and other biological material. This process provides an efficient technique for preservation of temperature sensitive and biologic products such as proteins, enzymes, blood plasma, and vaccines.

The global lyophilization/freeze drying equipment market size was valued at US$ 2,116.5 million in 2017, and is expected to exhibit a robust CAGR of 6.5% over the forecast period (2018 – 2026).

xIncreasing biopharmaceutical production with extensive R&D is expected to drive growth of the market

Increasing number of drug development process and biopharmaceutical research is a major factor augmenting growth of the market as lyophilization is widely used for pharmaceuticals/ biopharmaceuticals to improve stability, thereby achieve adequate shelf life. Lyophilization or freeze-drying is vital process in developing and manufacturing unstable and sensitive pharmaceuticals, as they aid in introducing new pharmaceutical to market. Biopharmaceuticals are produced by genetically modified organisms and are temperature sensitive complex molecules, which require gentle freeze drying with the lyophilisation process to attain adequate shelf life.

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According to the survey by Martin Christ GmbH, around 60% of the biopharmaceutical products, such as special cancer treatment substances and antibodies, require freeze drying for attaining efficient results in clinical trials. Also, increasing number of global biopharmaceutical companies is expected to boost market growth over the forecast period as these companies are highly dependent on lyophilization due to wide availability of biologics, which include vaccines, blood components, somatic cells, gene therapy, tissues, and recombinant therapeutic proteins. According to Pharmaceutical Research and Manufacturers of America (PhRMA), 2016, biopharmaceutical companies are focused on developing drugs for treatment of diseases such as cancers which has 1,919 medicines in development, 563 medicines for cardiovascular diseases and 1,123 medicines for immunological disorders, which require recombinant proteins for various stages for drug development. Also, according to Pharmaceutical Research and Manufacturers of America (PhRMA), 2016, member companies invested an estimated US$ 58.8 billion in research and development in 2015, which was the majority of all biopharmaceutical R&D spending in the U.S.

Increasing funds and high investment for development of drugs to accelerate market growth in Asia Pacific

The lab-scale freeze dryers are used in R&D prior to a scale up, as moving a new product to commercial-scale manufacturing requires careful validation. Demonstrating batch uniformity is an essential part of this critical process. Moreover, freeze-drying has created novel opportunities in the area of oral drug delivery, where the properties of the drugs, excipients and characteristics of the final solid dosage form can be modified by the freeze-drying process. Asia Pacific region is estimated to witness significant growth in the market, owing to increasing number of research laboratories and pharmaceutical companies with increased expenditure on research and development in this region.

Major players operating in the global lyophilization/freeze drying equipment market include Thermo Fisher Scientific, Inc., Millrock Technology Inc., Zirbus Technology GmbH, SP Scientific, Azbil Telstar, S.L., Biopharma Process Systems Ltd., LTE Scientific Ltd., Martin Christ GmbH, GEA Group, and Cuddon Freeze Dry.

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The study offers a synopsis of significant details such as the regional landscape of the industry as well as the firms that have established a strong position in the market.

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New Post has been published on iHealthcareAnalyst, Inc. - Healthcare Market Research

iHealthcareAnalyst, Inc. announced Healthcare Market Research and Consulting Services -

iHealthcareAnalyst, Inc. News – 31-May-2016 – Missouri. U.S. – iHealthcareAnalyst, Inc., a global health care market research and consulting company announced syndicate, custom and consulting grade reports in the following categories: Animal Health Care, Biotechnology, Clinical Diagnostics, Health Care Informatics, Health Care Services, Medical Devices, Medical Equipment, and Pharmaceuticals.

Animal Health Care

Antiseptics and Disinfectants, Diagnostics and Therapeutics, Drugs, Vaccines, Feed Additives, Genetic Testing

Biotechnology

Bioinformatics, Biopharmaceuticals, Biologicals, Enzymes, Cell Culture, Media, Reagents, Consumables, Immunoassays, In Vitro Diagnostics, Microbiology Cultures, Microscopes and Cameras, Molecular Diagnostics, Next Generation Sequencing, Polymerase Chain Reaction, Stem Cells, etc.

Clinical Diagnostics

Autoimmune Diseases, Cancers, Cervical Cancer, Companion Cancers, Dermatology, Enteric Diseases, Hospital-acquired Infection, Lateral Flow Diseases, Noninvasive Prenatal, Preimplantation Genetic Diagnosis. Rapid Diagnostics, Respiratory Diseases, etc.

Health Care Informatics

Cloud Computing in Health Care, Electronic Health Records, Medical Device Sensors, Medical Robotic Systems, Microelectromechanical Systems, Mobile Health (mHealth), Population Health Management Solutions, Preventive Health Care Technologies and Services, Telehealth and Telemedicine, Biometric Systems, etc.

Health Care Services

Ambulance, Ambulatory Emergency Care, Biomedical Waste Management, Business Process Outsourcing, Clinical Laboratory Diagnostics, Cord Blood Banking, Geriatric Care, Health Care Contract Manufacturing, Home Health Care, Home Rehabilitation, Medical Tourism, Medical Transcription, Urgent Care Centers, Video Telemedicine, etc.

Medical Devices

Ablation Technologies, Acute Care Needleless Connectors, Anesthesia, Angioplasty Balloons, Atrial Fibrillation, Autoinjectors, Biopsy, Blood Flow Measurement, Blood Pressure Monitoring, Blood Processing, Bone Grafts and Substitutes, Bone Osteosynthesis, Breast Imaging, Breast Pumps, Cardiac Pacemakers, Cardiopulmonary Stress Testing, Compression Therapy, Contrast Media Injectors, Dental Prosthetics, Disposable Syringes, Gynecology, Implantable Drug Delivery, Interventional Cardiology, Medical Infection Control, Ophthalmology, Oxygen Therapy, Pain Management, Personal Mobility, Radiofrequency Ablation, Respiratory, Spinal Trauma, Ultrasound, Wearable Medicals, Wound Closure, etc.

Medical Equipment

Capnography, Casting and Splinting, Dental, Lyophilization, Medical Gases, Medical Imaging, Multiparameter Patient Monitoring, Operating Room, Orthodontics, Rental, Spectrometry, Surgical, etc.

Pharmaceuticals

Active Pharmaceutical Ingredients, Anti-Aging, Antibacterial, Breast Cancer, Collagen Peptides, Contraceptives, Diabetes, Dilated Cardiomyopathy, Dyslipidemia, Epigenetics, Erectile Dysfunction, Gelatin, Geriatric Medicines, Highly Potent API, Hospital Pharmaceuticals, Hospital-Acquired Infections, Hospital-Acquired Pneumonia, Hypertrophic Cardiomyopathy , Inhalation and Nasal Spray, Kidney Cancer, Liver Diseases, Mouth Ulcers, Non-Small Cell Lung Cancer, Oral Contraceptives, Organ Transplant Immunosuppressants, Osteoporosis, Pain Management, Parenteral Nutrition, Peptides, Pharmacovigilance, Primary Immunodeficiency Diseases, Pulmonary Arterial Hypertension, Radiopharmaceuticals, Smoking Cessation , Thyroid Gland Disorders, etc.

About Us

iHealthcareAnalyst, Inc. is a global health care market research and consulting company providing market analysis, and competitive intelligence services to global clients. The Company has published about 150+ reports covering 70+ companies and 20+ countries in Animal Health Care, Biotechnology, Clinical Diagnostics, Health Care Informatics, Health Care Services, Medical Devices, Medical Equipment, and Pharmaceuticals.

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Lyophilization Services for Biopharmaceuticals Market Demand 2020 to 2027

Research Kraft has provided an exclusive analysis of global Lyophilization Services for Biopharmaceuticals Market Size, Status and Forecast to 2027 gives a detailed analysis of the market with key company profiles. The report gives a thorough evaluation of the market structure which fuses evident perceptions about the market for a predicted timeframe from 2020 to 2027. The report actively includes informative aspects relating to product developments, launches, and trends, to assist market players, shareholders, and investors in strategic decision making.

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The analysis of the market are explained below:

Leading key players in the market are:  Dalton Pharma Services, GILYOS, Jubilant HollisterStier, Biopharma Process Systems, Piramal Pharma Solutions, Biofortuna, Symbiosis Pharmaceutical Services Global Lyophilization Services for Biopharmaceuticals Market Segment by Applications considering Consumption Growth Rate and Market Share:

Pharmaceutical & Biotechnology Companies

Research Institutes

Others

worldwide Lyophilization Services for Biopharmaceuticals Market Segment by Product Types considering Production, Revenue (Value), Price Trends:

Product & Cycle Development

Clinical Manufacturing

Commercial Manufacturing

Freeze Drying Analytical Services

Region Analysis

The report analysis of the markets across five major regions: North America, Europe, Asia-Pacific (APAC), Middle East and Africa (MEA), and South & Central America. The exhaustive PEST analysis is done for each region to assess major external factors which may influence Lyophilization Services for Biopharmaceuticals Market in the coming years.

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Highlights of the report:

Fathom the present and unavoidable predetermination of the Lyophilization Services for Biopharmaceuticals Market in both made and making markets.

Extra and cut time doing zone level examination by watching the new development, size, driving players and parts inside the general Market.

The report edifies the bit expected to overwhelm the Lyophilization Services for Biopharmaceuticals industry and market.

To look at and consider the market status and hypothesis among as a rule enormous zones.

To examine the general key regions advance potential and bolstered position, opportunity and challenge, controls and dangers.

Emerging niche segments and regional markets.

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Lyophilized Powder Market 2019 to 2026 With Top Countries Data : Market Growth, Competitive Analysis includes Key Players

Latest Report added to database “Global Lyophilized Powder Market Trends & Forecast 2019-2026” by Data Bridge Market Research

The Lyophilized Powder market research report is a resource, which provides current as well as upcoming technical and financial details of the industry to 2026. The market report also computes the market size and revenue generated from the sales. This report presents with the key statistics on the market status of global and regional manufacturers and also acts as a valuable source of leadership and direction.

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The Major players profiled in this report include S. G. Biopharm Pvt. Ltd.; Pace Biotech.; Dalton Pharma Services; Aqua Vitoe Laboratories; Merck KGaA; Piramal Pharma Solutions; Baxter Healthcare Corporation.; VWR International, LLC.; GREEN CROSS CORP; Alfasigma S.p.A.; Ipsen Biopharmaceuticals, Inc; Xellia Pharmaceuticals; among others.

Competitive Rivalry-: The Lyophilized Powder report incorporates the detailed analysis of the leading organizations and their thought process and what are the methodologies they are adopting to maintain their brand image in this market. The report aides the new bees to understand the level of competition that they need to fight for to strengthen their roots in this competitive market.

Conducts Overall LYOPHILIZED POWDER Market Segmentation: This knowledgeable market research report offers lucrative opportunities by breaking down complex market data into segments on the basis of –

By Types (Microbial, Animal, Plants),

Application (Food, Feed, Soap, Pharmaceutical)

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Tert-butanol Market is anticipated to expand at a CAGR of nearly 4% during the forecast period

Tert-butanol Market: Key Highlights

·         The global tert-butanol market was valued at US$ 472.3 Mn in 2018, and is anticipated to expand at a CAGR of nearly 4% during the forecast period.

·         The global tert-butanol market is driven by the rise in the demand for solvents and co-solvents in the paints & coatings industry.

·         Asia Pacific accounts for a prominent share of the global tert-butanol market, led by rapid urbanization and industrialization in the region. 

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Key Drivers of the Tert-butanol Market

·         Tert-butanol is used as a solvent or co-solvent in paints, coatings, inks, and adhesives. It is also used in varnishes, resins, gums, dyes, camphor, vegetable oils, dyes, waxes, resins, shellac, rubbers, and alkaloids. The demand for tert-butanol in Asia Pacific is expected to rise significantly during the forecast period, owing to the growth in the construction sector and automotive industry in the region.

·         Flavors and fragrances are extensively used in industries such as food, perfumes, toiletries, cosmetics, and chemicals. Rise in the demand for air fresheners and deodorizers, and increasing consumer preference for diverse tastes, ranging from traditional scents to international luxury brands and niche fragrances, are driving the global tert-butanol market.

·         Tert-butanol is employed as a denaturant in the denaturing of ethyl alcohol. It possesses excellent solvating properties and high oxidation stability. Denatured alcohol is employed in various end-use industries as a fuel additive, cleaning agent, exterminator, sanding aid, and solvent. Rise in the demand for denatured alcohol in various applications as a disinfectant and cleaning agent is projected to boost the demand for tert-butanol during the forecast period. 

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 Tert-butanol Market: Pharmaceutical Segment to Offer Attractive Opportunities

·         Tert-butanol has been identified as a potential freeze-drying agent in the manufacturing of pharmaceutical compounds, especially in the preparation of stable powdered products. Solutions that are used for freeze-drying are known as organic co-solvent systems. Tert-butanol dissolved in water is one of the most utilized co-solvent systems.

·         Increase in research activities on drug development and biopharmaceutical research across the globe is a major factor augmenting the growth of the tert-butanol market, as lyophilization or freeze-drying agents are widely used to improve stability and increase the shelf life of pharmaceuticals/biopharmaceuticals.

·         Rise in the demand for biopharmaceutical products such as special cancer treatment substances and antibodies, which require freeze-drying for attaining efficient outcomes in clinical trials, is anticipated to provide lucrative opportunities to manufacturers of tert-butanol in the market. 

Limited Availability of Propylene Oxide (PO)/Tert-butanol (TBA) Plants and Stringent Government Regulations on VOC Emitting Solvents to Hamper Market Growth

·         Propylene oxide is a chemical intermediate primarily used in the production of polyether polyols and propylene glycol. PO/TBA plants provide propylene derivatives and co-products such as tert-butanol and isobutylene. Tert-butanol is employed in the production of methyl tertiary butyl ether (MTBE), which is blended into gasoline to enhance the octane number, and thereby lower vehicle emissions.

·         The global tert-butanol market is impacted by the limited supply of propylene oxide, due to disruptions in operations between 2016 and 2017. Rise in the inclination toward biofuel and the restricted usage of MTBEs and ETBEs, typically in the U.S., are also hampering the overall sales of tert-butanol.

·         Increase in the number of regulations on VOC emissions from paints, coatings, printing inks, and industrial and domestic cleaning products; and rise in environment-related awareness have adversely affected the demand for petroleum-based solvents. Thus, the rise in environment-related regulations on VOC emissions is expected to hamper the global tert-butanol market during the next few years. 

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 Asia Pacific Prominent in the Tert-butanol Market

·         Based on region, Asia Pacific accounted for a major share of the global tert-butanol market in 2018. The demand for tert-butanol as a solvent in paints & coatings is high in the region, especially in developing economies such as China, India, and ASEAN, due to rapid urbanization and industrialization.

·         China is projected to lead the market in Asia Pacific in the next few years, due to the burgeoning construction and automotive industries in the country. Rise in the demand for efficient and long-lasting coatings for construction and automotive industries is likely to fuel the tert-butanol market in the country during the forecast period.

·         Total investments in real estate development in China stood at US$ 1,496.91 Bn from 2017 to 2018, an increase of 6.9% from the previous year. China has been consuming a significant amount of construction materials such as cement and paints & coatings over the last few years, due to the increase in construction output and growth in GDP. China’s economy has been expanding at a high pace. It is stimulated by rapid industrialization, imports and exports, consumer consumption, and capital investments. These factors are boosting the tert-butanol market in the country. 

Tert-butanol Market: Top Four Players Account for More than 50% Market Share

·         LyondellBasell Industries N.V. established a new propylene oxide (PO) and tertiary butyl alcohol (TBA) plant in Texas, the U.S., in 2018. The plant is expected to commence operations by 2021. It is anticipated to produce 1 million tons of tert-butanol, annually. The company is estimated to have invested US$ 2.4 Bn in the project due to the increase in export demand for polyurethanes and cleaner-burning oxyfuels.

·         In 2012, Huntsman Corporation and the Sinopec Jinling Petrochemical Corporation (Sinopec Jinling) established a joint venture to build a PO/MTBE plant in Nanjing, China, by utilizing the former’s proprietary PO/MTBE manufacturing technology. The plant became operational in 2017. It produces propylene oxide derivatives, MTBEs, and co-products such as tert-butanol. 

The tert-butanol market is dominated by a few large and medium players that operate across the globe. The top four players — LyondellBasell Industries N.V., Lotte Chemical Corporation, Wanhua Chemical Group Co., Ltd., and Evonik Industries AG — accounted for around 53% share of the tert-butanol market in 2018. Other major players operating in the global tert-butanol market are Tiande Chemical Holdings Limited, ZiBo Haizheng Chemical Co., Ltd., Sinopec Corp., and Maruzen Petrochemical Co., Ltd. 

Global Tert-butanol Market: Research Scope 

Global Tert-butanol Market by Application

·         Solvents & Intermediates

o    Paints & Coatings

o    Pharmaceuticals

o    Flavors & Fragrances

o    Others (including Floating Agents and Stabilizers)

·         Ethanol Denaturants

·         MTBEs & ETBEs

·         Methylmethacrylates (MMAs)

·         Others (Chromatography)

Global Tert-butanol Market by Region

·         North America

o    U.S.

o    Canada

·         Europe

o    Germany

o    France

o    U.K.

o    Italy

o    Spain

o    Russia & CIS

o    Rest of Europe

·         Asia Pacific

o    China

o    Japan

o    India

o    ASEAN

o    Rest of Asia Pacific

·         Latin America

o    Brazil

o    Mexico

o    Rest of Latin America

·         Middle East & Africa

o    GCC

o    South Africa

o    Rest of Middle East & Africa        

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Transparency Market Research is a global market intelligence company, providing global business information reports and services. Our exclusive blend of quantitative forecasting and trends analysis provides forward-looking insight for thousands of decision makers. Our experienced team of analysts, researchers, and consultants use proprietary data sources and various tools and techniques to gather and analyze information.

Our data repository is continuously updated and revised by a team of research experts, so that it always reflects the latest trends and information. With a broad research and analysis capability, Transparency Market Research employs rigorous primary and secondary research techniques in developing distinctive data sets and research material for business reports.  

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Lyophilization/Freeze Drying Equipment Market to Reflect Steady Growth During 2018 – 2026

The global lyophilization/freeze drying equipment market size was valued at US$ 2,116.5 million in 2017, and is expected to exhibit a robust CAGR of 6.5% over the forecast period (2018 – 2026).

Increasing number of drug development process and biopharmaceutical research is a major factor augmenting growth of the market as lyophilization is widely used for pharmaceuticals/ biopharmaceuticals to improve stability, thereby achieve adequate shelf life. Lyophilization or freeze-drying is vital process in developing and manufacturing unstable and sensitive pharmaceuticals, as they aid in introducing new pharmaceutical to market. Biopharmaceuticals are produced by genetically modified organisms and are temperature sensitive complex molecules, which require gentle freeze drying with the lyophilisation process to attain adequate shelf life. According to the survey by Martin Christ GmbH, around 60% of the biopharmaceutical products, such as special cancer treatment substances and antibodies, require freeze drying for attaining efficient results in clinical trials.

Also, increasing number of global biopharmaceutical companies is expected to boost market growth over the forecast period as these companies are highly dependent on lyophilization due to wide availability of biologics, which include vaccines, blood components, somatic cells, gene therapy, tissues, and recombinant therapeutic proteins. According to Pharmaceutical Research and Manufacturers of America (PhRMA), 2016, biopharmaceutical companies are focused on developing drugs for treatment of diseases such as cancers which has 1,919 medicines in development, 563 medicines for cardiovascular diseases and 1,123 medicines for immunological disorders, which require recombinant proteins for various stages for drug development. Also, according to Pharmaceutical Research and Manufacturers of America (PhRMA), 2016, member companies invested an estimated US$ 58.8 billion in research and development in 2015, which was the majority of all biopharmaceutical R&D spending in the U.S.

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Moreover, according to the survey by Future Science Group, 2016, injectable products are majorly selected as formulations for new therapeutics. However, liquid formulations often enhances degradation through hydrolysis. Thus, lyophilization/ freeze-drying is regularly used in pharmaceutical manufacture to reduce water activity and assure product stability.

The lab-scale freeze dryers are used in R&D prior to a scale up, as moving a new product to commercial-scale manufacturing requires careful validation. Demonstrating batch uniformity is an essential part of this critical process. Moreover, freeze-drying has created novel opportunities in the area of oral drug delivery, where the properties of the drugs, excipients and characteristics of the final solid dosage form can be modified by the freeze-drying process. Asia Pacific region is estimated to witness significant growth in the market, owing to increasing number of research laboratories and pharmaceutical companies with increased expenditure on research and development in this region. For instance, according to the National Bureau of Statistics, February 2018, China’s expenditure on research and development increased by 11.6% in 2017 from 10.6% in 2016 reaching to US$ 280 Bn in 2017. According to the International Journal of Sciences, January 2018, China’s biotechnology sector is expected to exceed by 4% of gross domestic product by 2020, and is expected to develop around 10-20 life-science parks for biomedicine with an output surpassing US$ 1.5 billion.

Major players operating in the global lyophilization/freeze drying equipment market include Thermo Fisher Scientific, Inc., Millrock Technology Inc., Zirbus Technology GmbH, SP Scientific, Azbil Telstar, S.L., Biopharma Process Systems Ltd., LTE Scientific Ltd., Martin Christ GmbH, GEA Group, and Cuddon Freeze Dry.

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Lyophilization Equipment and Services Market to grow US$4.8 Bn by 2020

The global lyophilization equipment and services market is primarily driven by a thriving biopharmaceutical industry and rise in contract services, states Transparency Market Research in its latest report. The report is titled “Lyophilization Equipment and Services Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020”.

The lyophilization market is estimated to grow from a value of US$2.7 Bn in 2013 to US$4.8 Bn by 2020. Developing healthcare sector in emerging economies and introduction of new technologies is projected to boost the market at an 8.50% CAGR from 2014 to 2020.Lyophilization equipment includes tray lyophilizers, freeze drying microscopes, bench-top lyophilizers, and rotary lyophilizers. Accounting for a share of over 45.0% in 2013, tray lyophilizers dominated the market driven by long-term stability of pharmaceutical products and growing use in large-scale production systems. Lyophilization services include aseptic filling, cycle development, and bulk lyophilization. Bulk lyophilization is the largest and the most rapidly developing service segment and is projected to expand at a 6.50% CAGR from 2014 to 2020.

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Lyophilization equipment and services find application in several industries including biopharmaceuticals, nutraceuticals, pharmaceuticals, and diagnostics. The demand for lyophilization equipment and services from the pharmaceutical industry was the highest in 2013 owing to its significant role in the manufacturing division.

The worldwide market for lyophilization equipment and services is segmented on the basis of geography into North America, Latin America, Europe, Asia Pacific, the Middle East, and Rest of the World. Europe dominated the global market in 2013, driven by a number of factors such as increase in number of clinical trials, presence of skilled workforce, and development of advanced technologies to enhance product portfolio.

Asia Pacific, on the other hand, is anticipated to be the fastest developing regional segment of the lyophilization equipment and services market. The rapid growth in the region can be attributed to rising adoption of novel technologies, favorable government policies, fast-growing consumer market, presence of skilled labor, and growing scope of contract manufacturing activities in countries such as India, Thailand, China, Malaysia, and Vietnam.

The vendor landscape of the lyophilization equipment and services market is immensely fragmented owing to the presence of several emerging and established biopharmaceutical companies. The leading players contributing towards the growth of the global lyophilization equipment and services market include Irvine Pharmaceutical Services, Biopharma Technology, Ltd., Lyophilization Technology, Inc., Azbil Telstar, S.L., ZIRBUS Technology GmbH, W.L. Gore & Associates, Inc., Aseptic Technologies, BioPharma Solutions, SP Scientific, LSNE Contract Manufacturing, and Thermo Fisher Scientific, Inc. These vendors are analyzed on the basis of company overview, financial standing, recent developments, business strategies, and product portfolio.

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Novel Drug Reconstitution Systems Market Size, Application Analysis, Regional Outlook, 2017 - 2025

Drug reconstitution can be a challenging task for non-professionals managing a chronic illness. The dosage forms should ideally be easy to administer, safe, and cost-effective. However, in order to ensure chemical and physical stability of the product, most drugs are formulated in the lyophilized form to be reconstituted at the time of administration. The lyophilized form maintains drug stability and efficacy during the shelf-life period and reduces the time required to make products stable in liquid dosage forms. This enables rapid entry of a new drug into the market, maintaining the market competitiveness. Reconstitution and mixing was a tedious job earlier; however, technological advancements have resulted in the development of novel drug reconstitution systems, making the reconstitution process easier with minimum dosing errors. These systems are highly preferred by patients, as they are well-engineered to reduce their efforts and help them stick to the dosage regimen. Selecting the right reconstitution alternative depends upon the type of drug, the diluent volume type, the administration method, and overfill issues.

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Growing research and development activities by pharmaceutical and biopharmaceutical vendors, rising prevalence of several chronic diseases, increasing health care expenditure worldwide, and benefits of novel drug reconstitution systems are factors driving the global novel drug reconstitution systems market. Reconstitution systems offer several advantages such as ease of administration, reduced drug loss, decreased need for overfilling by manufacturers, improved safety, and better patient compliance. Moreover, increasing inclination toward self-administration of drugs and increasing trend of development of patient-centric drug delivery systems by manufacturers are expected to boost the global novel drug reconstitution systems market during the forecast period. However, increased costs of products led by introduction of novel techniques and stringent regulatory requirements are factors restraining the global novel drug reconstitution systems market.

The global novel drug reconstitution systems market can be segmented based on product, distribution channel, and region. In terms of product, the market can be categorized into vial adaptors, vial-to-vial systems, needleless transfer devices, direct connection to vial devices, and dual chamber syringes. Vial adapters are quick, safe, and cost-effective. They improve the reconstitution performance. A vial adapter contains a syringe with or without diluent filled in it and a vial containing lyophilized drug. The vial-to-vial system comes with an adapter connecting two vials. This is an attractive type of novel drug reconstitution system, as it does not require needles. The direct connection to vial devices enables manufacturers to design a compact packaging for the product. In terms of distribution channel, the global novel drug reconstitution systems market can be segmented into hospital pharmacy, retail pharmacy, and e-commerce system. The retail pharmacy segment is expected to hold the maximum market share by the end of the forecast period. The e-commerce segment is anticipated to expand at the maximum CAGR during the forecast period.

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Geographically, the global novel drug reconstitution systems market can be segmented into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. North America dominates the global novel drug reconstitution systems market, owing to growing incidence of chronic diseases, high adoption of technologically advanced products in the region, high health care expenditure, and growing R&D activities to develop novel products to enhance patient comfort by players in the U.S. Europe is the second-largest market for novel drug reconstitution systems, due to growing geriatric population, increasing investments in R&D activities, and rising adoption of novel drug delivery systems to treat chronic conditions. Asia Pacific is considered as an emerging market for novel drug reconstitution systems, owing to presence of developing economies, increasing health care expenditure, and constantly rising population in the region.

Key players operating in the global novel drug reconstitution systems market are West Pharmaceutical Services, Inc., Integrity Bio, Inc., Sensile Medical AG, Yukon Medical, Nemera, Credence MedSystems, Inc., Alkermes, and Baxter.

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