#NVIDIABioNeMo

[govindhtech]

Cadence Debut Millennium M2000 Supercomputer With NVIDIA

Cadence unveils an NVIDIA-accelerated supercomputer at CadenceLIVE, transforming engineering simulation and design.

Silicon Valley CadenceLIVE

At its annual CadenceLIVE Silicon Valley event today, Cadence Design Systems announced a huge development in AI-driven engineering design and scientific simulation through close integration with NVIDIA accelerated computing hardware and software. NVIDIA's newest technology powers the Millennium M2000 Supercomputer, which offers unmatched performance for digital twin simulations, drug discovery, and semiconductor design.

NVIDIA Millennium M2000 Supercomputer

Millennium M2000 Supercomputer surpasses CPU-based predecessor. RTX PRO 6000 Blackwell Server Edition GPUs and NVIDIA HGX B200 systems are included. Hardware and optimised software like NVIDIA CUDA-X libraries power the system. This mix of cutting-edge hardware and customised software is touted to produce up to 80x better performance for critical system design, EDA, and biological research tasks than the previous generation. Engineers and academics may now run complex, comprehensive simulations thanks to this speed boost.

This enhanced processing capability should lead to advances in several areas. The Millennium Supercomputer accelerates molecular design, data centre design, circuit modelling, and CFD. that more accurate insights enable faster pharmaceutical, system, and semiconductor development.

It may affect the development of pharmaceuticals, data centres, semiconductors, and autonomous robots. The sources also include Cadence's platform integrations, such as NVIDIA Llama Nemotron reasoning models in the JedAI Platform and NVIDIA BioNeMo NIM microservices in Orion.

CadenceLIVE featured the CEO and founder of NVIDIA and Cadence's president discussing the relationship behind this new supercomputer. Devgan says this discovery has been “years in the making,” requiring Cadence to update its software and NVIDIA to upgrade hardware and systems to take use of the new capabilities. Leaders emphasised cooperative initiatives on digital twins, agentic AI, and AI factories. AI will permeate everything humans do, and “every company will be run better because of AI, or they’ll build better products because of AI.”

NVIDIA aims to buy 10 Millennium Supercomputers based on the GB200 NVL72 architecture, emphasising this relationship. This significant acquisition aims to speed up NVIDIA's chip design processes. Huang said NVIDIA has started developing its data centre infrastructure to prepare for this purchase, calling it a “big deal”.

The sources provide examples of this sophisticated technology's use. NVIDIA engineers utilised Cadence Palladium emulation and Protium prototype systems for chip bring-up and design verification during Blackwell development. However, Cadence modelled aeroplane takeoff and landing fluid dynamics using the Cadence Fidelity CFD Platform and NVIDIA Grace Blackwell-accelerated systems.

The NVIDIA GB200 Grace Blackwell Superchips and Cadence platform completed a “highly complex” simulation in less than 24 hours that would have taken days on a huge CPU cluster with hundreds of thousands of cores. Cadence used NVIDIA Omniverse APIs to display these complicated fluid dynamics.

Integration covers AI infrastructure design and optimisation as well as physical simulations. Cadence uses the NVIDIA Omniverse Blueprint and Cadence Reality Digital Twin Platform for AI industrial digital twins. This connection lets engineering teams employ physically based models to optimise AI factory components like energy, cooling, and networking before construction. This functionality makes next-generation AI factories future-proof and speeds up setup decisions.

Live Silicon Valley 2025

CadenceLIVE Silicon Valley 2025 featured the Millennium M2000 Supercomputer and the wide relationship. At the Santa Clara Convention Centre on May 7, 2025, Cadence users may network with engineers, business leaders, and experts in electrical design and intelligent systems.

Cadence describes LIVE Silicon Valley 2025 as a day of education, networking, and cutting-edge technology. Participants can improve by understanding best practices and practical solutions. Keynote speeches from industry pioneers are a highlight of the event. The Designer Expo showcases cutting-edge concepts and connects attendees with Cadence experts and innovators. It brings brilliant people together for a day of inspiration and creativity.

The Cadence-NVIDIA collaboration, highlighted by the Millennium M2000 Supercomputer and its presentation at CadenceLIVE, seeks to integrate AI and accelerated computing into engineering design and scientific discovery by drastically reducing time and cost and enabling previously unattainable simulation complexity and detail.