#ard i need context please | Explore Tumblr Posts and Blogs

mobilebuilder0 · 4 years

Text

What to Look For In a Beauty Supply Store

Are you interested in updating your beauty products and supplies or are you just interested in replenishing your supply? If you are, you will need to find a beauty supply store to shop at, if you don’t already have a favorite one. When it comes to finding the perfect beauty supply store to shop at, it may require a little bit of time and research, but it will likely be more than worth it in the end. For instance, you could end up saving yourself a considerable amount of time and possibly even money by taking the time to find the perfect beauty supply store to shop at.

When it comes to finding the perfect beauty supply store to shop at, there are a number of factors that you may want to think about taking into consideration. One of those factors is location. If you live in a large town or city, there is a good chance that you have a beauty supply store or even a number of them nearby. However, if you live in a small town, you may have to travel quite some distance to find a popular or highly rated and recommend beauty supply store. If that is the case and you do not want to travel, but you still need to buy your beauty supplies and products, you need to remember that beauty supply stores come in a number of different formats. In addition to storefront locations, beauty stores are also operated online as well.

The products sold at a beauty supply store are also something else that you should take into consideration, when trying to find the perfect beauty supply store to shop at. Beauty supply stores commonly sell hair care products, nail care products, skin care products, makeup, and much more, but there aren’t any guarantees. If you are able to get the telephone number of a local beauty supply store, you may want to think about contacting the store in question to learn more about the products that they carry. This can save you time, especially if the beauty supply store is a distance away from your home. Also, for the largest selection of beauty supplies and products, you may want to think about shopping online.

In addition to the types of products sold at a beauty store, you may also want to examine the prices that those products are being sold for. What you need to remember is that beauty products and supplies cost different amounts of money. For instance, you should be prepared to pay more for a curling iron than you would if you were just shopping for some shampoo and conditioner. With that in mind, however, you can still examine the prices that a particular beauty supply store charges. Be on the lookout for products that seem like they are priced too high. Some beauty supply owners, like all other retailers, are known to overcharge some of their clients, in hopes of making a larger profit.

The staff at a beauty supply store should also be taken into consideration, especially if you are looking for a local store to shop at. If you have never visited the beauty store in question, you may not necessarily know what their staff is like. Should you choose to visit or shop at the store, pay close attention to the staff. Beauty supply stores are often known for their helpful staff. If you regularly have a difficult time buying beauty supplies and products, you may want to make sure that you shop at a beauty supply store that has a reputation of being helpful, kind, and compassionate.

The above mentioned factors are just a few of the many that you may want to keep in mind, when looking to find the perfect beauty supply store to shop at. For a large selection of beauty supply stores to visit or get a closer look at, you may to think about using your local phone book, performing a standard internet search, using an online business directory, or asking those that you know for recommendations.

Image from page 201 of “Rambles through the British Isles” (1870)

Image by Internet Archive Book Images Identifier: ramblesthroughbr00harcrich Title: Rambles through the British Isles Year: 1870 (1870s) Authors: Harcourt, Richard Subjects: Methodist Episcopal Church Methodist Church — Clergy Great Britain — Description and travel Publisher: New York : Carlton & Lanahan Cincinnati : Hitchcock & Walden Contributing Library: University of California Libraries Digitizing Sponsor: MSN

View Book Page: Book Viewer About This Book: Catalog Entry View All Images: All Images From Book

Click here to view book online to see this illustration in context in a browseable online version of this book.

Text Appearing Before Image: ards the basin, througli which the cargoes arc raiseddirectly out of the ships—thus saving the time and labor of theold plan of depositing them on the quay. In rambling throughthese store-houses of the nations wealth, and in studying theeflFects of the commingling of nationalities in this busy mart ofcommerce, I thought of the beauty and force of Addisonswords, where he says, in referring to the advantages of com-merce upon nations : I am wonderfully delighted to see a body of men thrivingin their own fortunes, and at the same time promoting the pub-lic stock; or, in other words, raising estates for their own fam-ilies, by bringing into their country, whatever is superfluous.Nature seems to have taken a particular care to disseminate herblessings among the regions of the world, with an eye to theirmutual intercourse and traffic among mankind, that the nationsof the several parts of the globe might have a kind of depend-ence upon one another, and be united by their common in-terests.

Text Appearing After Image: Thcic the wicked ceisc fiom tioiibling XXI. Graves of the Giieat anb Good. The dead, how sacred I sacred is the dust Of this heaven-lahored form, erect, divine —Thomson. ^J^ fy^ o -^ AVING a great desire to see City Eoacl Chapel^ ^ifS^-^iP while in London, I made out to spend a part^^KS °^ ^ Sabbath within its sacred walls. ThelOi >^ day I visited it, tbe regular minister wasabsent, and his place was supplied by a strangerHere it was, on the occasion of the laying ofthe foundation in 1777, John Wesley preached a ser-mon from the words, According to this time, it sballbe said. What hath God wrought! And now, after the lapseof almost a hundred years, his sons in the gospel take up thesame text, and in looking at what has been accomplished, ex-claim in holy triumph,

What hath God wrought! The building is composed of brick, with cut stone trimming,and is still good ; it must have been considered more thancommon in its day. It stands in from the street, about onehundred feet, an

Note About Images Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability – coloration and appearance of these illustrations may not perfectly resemble the original work.

from https://news.talknewyorkcity.com/what-to-look-for-in-a-beauty-supply-store/

0 notes

im-trash-bye · 4 years

Text

What to Look For In a Beauty Supply Store

Image from page 201 of “Rambles through the British Isles” (1870)

View Book Page: Book Viewer About This Book: Catalog Entry View All Images: All Images From Book

Click here to view book online to see this illustration in context in a browseable online version of this book.

source https://news.talknewyorkcity.com/what-to-look-for-in-a-beauty-supply-store/

0 notes

a-panda-reads-act-omega · 7 years

Text

ACT OMEGA PART 26

THE 04/14/17 UPDATE

OH BOY HOW DO I WORK THIS DOODAD AGAIN BOY HOWDY I SURE FORGOT ABOUT TUMBLR FOR THE LONGEST FUCKING TIME

Whatever Alright so, I really don’t care enough to try and remind myself of what was going on during the last update so I’m just gonna get started on this one and hope for the best.

Alright so I kinda remember. Aranea just explained a ton of stuffs.

And Vriska isn’t pleased by it.

VRISKA: W8. VRISKA: So... what are you saying exactly? ARANEA: I thought I was fairly clear, 8ut I understand if this inform8tion is too jarring for you to a8sor8. ARANEA: It means that if nothing is done, everything that we know will cease to 8e. VRISKA: ... Everything. Really. ARANEA: Yes, Vriska. Everything. Every ghost. Every horrorterror. Every dream 8u88le, session, and universe. ARANEA: It will all eventually fall into The Pocket and 8e lost. ARANEA: Of course, this ensures that there is no point in time or space to which Lord English can escape. ARANEA: 8ut then again, the same goes for us.

Oh. Well shit. Apparently I was right.

They better get the fuck to work.

VRISKA: ........ ARANEA: If it is any consol8tion, from the perspective of any universes currently nestled inside of Skaia, this is 8usiness as usual. All universe die, and from the moment of the Vast Croak, they contain every instance of that universe and all of their histories at once. The residents of any given iter8tion have no real way of perceiving anything that occurs in this 8roader scope. They are free to live their mortal lives as they would have otherwise. ARANEA: As they say, ignorance is 8liss--a 8lessing that those of us among the dead cannot afford. 8ut the consequences of what we manage to accomplish will reach 8eyond such individual concerns and matter a gr8 deal to the masses yet to even 8e 8orn.

So, as I said.

They better get the fuck to work.

How do you even stop a black hole though? I mean, there’s like real world theories and shit but fuck real world. I already have sort of a theory. If they use The Tumor. Or, a tumor. I forget if that was a beta kids exclusive though, so really who knows if that’s even possible. But supposedly, the tumor has the capability to destroy the sun, so maybe if they could get some other tumor it could destroy the hole.

Why is everybody bein so J U Dgy. Fuck, just LOOK at Kankri back there. So hateful.

ARANEA: I did everything I could to prevent The Pocket from forming. ARANEA: In fact, I spent considera8le time and effort seeking out the Lost Cheru8 for myself. I planned to attempt reasoning with her, to convince her there must 8e some other way. 8ut she was far too elusive, and no doubt too dedic8ed to her cause to have listened if I HAD found her. ARANEA: So in the end, I failed, just as you did. I’m not too proud to admit that.

Well yeah, there was nothing you could ever do to prevent the worst thing possible from happening, that’s sort of a running theme in homestuck. You just kinda gotta. Find a loophole around the consequences.

Pf i forgot about double eyepatch sollux

Also, Wow Feferi sure is sad

ARADIA: i dont know about calling it a failure ARADIA: its just like you said isnt it? ARADIA: this was always bound to happen ARADIA: as i see it this is simply the story reaching its natural conclusion ARADIA: honestly im kind of excited! ARADIA: i had a hunch that this is how everything would end ARADIA: though the added context definitely makes it a lot more interesting

Goddammit Aradia pls take this seriously

FEFERI: So T)(IS is w)(at the )(orrorterrors meant. 38( FEFERI: T)(ey )(ave been w)(ispering about T)(-E -END for quite a w)(ale now. FEFERI: I t)(oug)(t t)(ey must )(ave been talking about Lord -Englis)( ripping t)(em and t)(eir bubbles apart! FEFERI: But t)(is makes muc)( more sense. FEFERI: It’s so )(ard to )(ear t)(eir sad little glubs now! FEFERI: Soon I t)(ink t)(ey will go quiet for good. 38(((

Oh. Well. I guess that’s bad. Yeah, the horror terrors dying is definitely a bad thing. God every time I take a break from liveblogging I lose so much context.

ARADIA: really? then whatever they have to say right now must be important! FEFERI: RIG)(T?! FEFERI: I am trying to listen carefully, but I must be )(earing t)(em wrong! FEFERI: T)(ere was SOM-ET)(ING about... a door?

Well you have a house. Maybe a door’s gonna pop up soon.

SOLLUX: man i’m glad i’m n0t the 0ne hearing v0ices, for 0nce.

I really just love the sassy stance Meenah’s got over there.

ARANEA: Are you sure that’s what they said? ARANEA: A door? FEFERI: Um well it sure did SOUND like t)(at, but t)(at doesn’t make any sense! Does it? ARANEA: What else did they have to say a8out this door? FEFERI: Glub! Not)(ing I can make out yet, sorry! FEFERI: Just... T)(-E DOOR.

Well. HUHM. I dunno, they’re building this up quite a bunch, so I doubt it’s just gonna pop up and they’re gonna walk through it.

OOH! MAybe they can like, seal the black hole in the house Or something

I don’t know

FEFERI: I can keep listening if it’s important. ARANEA: Yes, please do. It is vitally important. ARANEA: That door is likely our 8est 8et at circumventing our current plight! MEENAH: wait MEENAH: a door MEENAH: they couldnt b talkin about the door that showed up on the weaprawn i mean weapon

I mean that seemed obvious to me

MEENAH: right? ARANEA: Actually, I 8elieve that is exactly what they are talking a8out. MEENAH: how the fuck would a DOOR save our asses exactly ARANEA: It’s not a8out the door. It’s a8out what’s 8EHIND the door. ARANEA: If I am right a8out the nature of the juju, then that door could very well lead to another realm entirely, one completely 8eyond the reach of the ever-expanding Pocket. ARANEA: It is the key to everything--the only logical next step to t8ke! ARANEA: Everything is slotting into pl8ce!

Oh boy. Well this should be interesting. I don’t exactly know how that’s gonna stop the pocket but hey we’ll see.

MEENAH: uh... MEENAH: youre losin me serks ARANEA: THINK, Meenah. The story isn’t over yet! ARANEA: The Lost Cheru8 has done her part. We have done ours in activ8ing the weapon. ARANEA: 8ut what of the warriors? The challengers Lord English trapped inside his juju? Where do they come in? MEENAH: uh?? ARANEA: They are through that door! Them and the higher plane they have 8een trapped within for eons! ARANEA: The warriors could 8e w8ing for us to find and free them so they might do their work in repairing the damage the Lost Cheru8 has done. ARANEA: After residing in what could well 8e a macrocosm of infin8 power, surely they have the means to accomplish anything! ARANEA: What could WE accomplish 8y going there ourselves? MEENAH: uhh??? ARANEA: If nothing else, the juju is the only way we can escape the destruction of reality itself! ARANEA: It is the only path to take that leads somewhere ELSE! MEENAH: arane--

It’s probably true. Probably. I dunno. I mean, I’m really curious to just see what’s behind this door already.

oh fuck

What did le do

MEENAH: what the anglin fuck?! ARANEA: It’s already 8egun. ARANEA: Lord English is as aware as I am of the juju’s potential. 8ut it seems his 8est course of action is to aimlessly attack it. Perhaps a 8yproduct of how unsta8le he has 8ecome.

Daddy Caliborn just needs to take a moment to chill. Enjoy a lil ice cream break maybe.

ARANEA: Instead of fleeing The Pocket, he will stu88ornly try to evade his f8 even while facing certain destruction. And 8arring that, he will do whatever it takes to take doom us all with him. ARANEA: He will not rest until the juju is destroyed. May8e he could even 8e attempting to enter it himself! Either way, we CANNOT allow him to take away our last hope!

So what’s the game plan? How do they plan on getting through there with Lord English goin all fuckin berzerk on this poor house.

MEENAH: ... MEENAH: yeah MEENAH: sure

Have some faith, Meenah.

O h thats a face.

ARANEA: “Sure”? ARANEA: You sound anything 8ut. ARANEA: Don’t you agree with me?

Call me crazy but I don’t think she does.

MEENAH: i mean yeah i guess MEENAH: all this stuff youve been spouting sounds legit MEENAH: maybe ARANEA: May8e. ARANEA: So, you don’t trust me. Is that it? MEENAH: i dunno! MEENAH: i wanna believe you MEENAH: but somefin just smells fishy MEENAH: mostly cause youre gettin kinda MEENAH: weird

To be fair, she’s always acting weird. I think the most worrying part about her behavior is how excited she is to pull this plan off. I don’t really think she’s gonna try to pull off another suicide plan. Worst case scenario, she tries to steal the glory from Vriska.

ARANEA: Weird? ARANEA: Reality is on the verge of collapse, 8ut I’M 8eing WEIRD? ARANEA: Don’t you realize what’s at st8ke?! MEENAH: Y-EA)( i do MEENAH: im just thinkin maybe we otter clear our heads before we bellyflop into anyfin ok geez MEENAH: wait for angelfish over there to synergize with the horrorglubbers or whatever ARANEA: Do you think we have time for that? At any moment, we could 8e erased forever! ARANEA: Don’t you CARE a8out DYING, Meenah?! MEENAH: i...

Nope. She doesn’t. She’s made this clear in the past (Look who’s been doing their Homestuck rereading. It’s me.)

ARANEA: You used to be so dedic8d to staying alive that you were willing to 8low us all up as a last resort! ARANEA: I know that we are all technically living on 8orrowed time. I am AWARE that every moment we’ve spent with our consciousnesses intact was a gift none of us really deserved. ARANEA: 8ut I’m not DONE YET!! ARANEA: I want to continue to exist! Don’t you?! ARANEA: I’ve 8een here for so long, trying to make the 8est of our situation, reaching new heights in skill and understanding, and yet I still...! MEENAH: 38(

Sorry Aranea, but I’m pretty sure Meenah has stopped giving a shit a while ago. Spending a zillion years alive/dead in the dream bubbles would do that to you.

ARANEA: Don’t you want to MATTER, Meenah? Don’t you want all of this to have meant something?! ARANEA: The fact that we were here, that we existed! If everything that ever was and ever will 8e is just going to disappear, then none of it will have ever meant ANYTHING! ARANEA: So please, just trust me! ARANEA: What scheme could I possi8ly have up my sleeve that would 8e worse than the alternative? What more could any of us have to lose?! ARANEA: All you have to do is listen

Yeah- Aranea you’re desperate ramblings aren’t helping to make you seem more trustworthy. You kinda need to CHILL a bit.

Oh my god. Sad mopey Meenah might be one of the best things I’ve ever seen? I wanna feel bAD because I SHOULD feel bad but it’s just too fuNny to look at for some reason.

MEENAH: ... fine MEENAH: whats ur big plan

And she gives in. All sad about it too. Good job Aranea, you made someone who don’t give a shit about nothing sad. S m h.

Goddammit Aranea she finally gives you the chance to explain your plan and you instantly go back to appearing more dramatic than you’ve earned the right to be.

ARANEA: We need to find a way past Lord English. While it might 8e within our a8ilities to defeat him as he is now, it feels to me like too much of a gam8le when so much rides on our success. We can simply lure him away with a proper distraction and deal with him l8er.

Well he’s not known for his brains so that should be easier than it sounds.

ARANEA: Really, the most sensi8le course of action is for me to call 8ack the remainder of the army. ARANEA: Perhaps it would even 8e 8est if I took control of the entire oper8tion? Surely you agree we don’t have time for any more petty squa88les. So long as I have control of the majority of our attack force, it would simply 8e more efficient for me to 8e calling the shots. Time is of the essence, after all.

Fuck yoooouuuu. But Yeah. It probably would be smart if You did that. Ahem.

WElp thats the end of this fucking liveblog what a goddamn miracle its finALLY RELEASED NOW PRAISE ME LIKE THE MESSIAH WHOSE RETURN HAD BEEN FORETOLD IN LEGENDS DATING BACK TO BEFORE MAN

bye

#hs act omega #Act Omega #act omega liveblog #hs act omega liveblog #homestuck #homestuck liveblog

2 notes · View notes

asrarblog · 4 years

Text

Dear Colleagues! This is Pharma Veterans Blog Post #346. Pharma Veterans welcomes sharing of knowledge and wisdom by Veterans for the benefit of Community at large. Pharma Veterans Blog is published by Asrar Qureshi on WordPress, the top blog site. Please email to [email protected] for publishing your contributions here.

Randomised Evaluation of COVID-19 Therapy (RECOVERY) is the current hot topic under discussion. In this blog, we look at the basic facts of the trial, its outcomes and the news surrounding it.

There is no doubt that RECOVERY Trial has produced exciting and encouraging results. However, the results and context must be understood more clearly. Any rush to take Dexamethasone on your own must be avoided. Even physician-advised improper use should be questioned and discouraged.

I have given below the summary for those who are not familiar with clinical trials and terms.

I have given a more detailed description for technically oriented readers. Further reading may be done by following the links at the end of this post.

I have given the Abstract of the publication prepared by the investigators.

The readers may choose accordingly.

The University of Oxford in UK is acting as the trial Sponsor. The trial is being coordinated by a Central Coordinating Office within the Nuffield Department of Population Health. This study is supported by a grant to the University of Oxford from UK Research and Innovation/National Institute for Health Research (NIHR) and by core funding provided by NIHR Oxford Biomedical Research Centre, the Wellcome Trust, the Bill and Melinda Gates Foundation, Health Data Research UK, and the Medical Research Council Population Health Research Unit, and NIHR Clinical Trials Unit Support Funding.

SUMMARY

The RECOVERY trial is a large, randomised controlled trial of possible treatments for patients admitted to hospital with COVID-19. Over 11,500 patients have been randomised (enrolled) to the following treatment arms, or no additional treatment:

Lopinavir-Ritonavir (commonly used to treat HIV)

Low-dose Dexamethasone (a type of steroid, which typically used to reduce inflammation)

Hydroxychloroquine (which has now been stopped due to lack of efficacy)

Azithromycin (a commonly used antibiotic)

Tocilizumab – ACTEMRA (an anti-inflammatory treatment given by injection)

Convalescent plasma (collected from donors who have recovered from COVID-19 and contains antibodies against the SARS-CoV-2 virus).

Overall dexamethasone reduced the 28-day mortality rate by 17% (0.83 [0.74 to 0.92]; P=0.0007) with a highly significant trend showing greatest benefit among those patients requiring ventilation (test for trend p<0.001).

But it is important to recognise that we found no evidence of benefit for patients who did not require oxygen and we did not study patients outside the hospital setting. Follow-up is complete for over 94% of participants.

DETAILED DESCRIPTION

Background: In early 2020, as this protocol was being developed, there were no approved treatments for COVID-19, a disease induced by the novel coronavirus SARS- CoV-2 that emerged in China in late 2019. The UK New and Emerging Respiratory Virus Threats Advisory Group (NERVTAG) advised that several possible treatments should be evaluated…

Eligibility and randomisation: This protocol describes a randomised trial among patients hospitalised for COVID-19. All eligible patients are randomly allocated between several treatment arms, each to be given in addition to the usual standard of care in the participating hospital

Numbers to be randomised: The larger the number randomised the more accurate the results will be, but the numbers that can be randomised will depend critically on how large the epidemic becomes. If substantial numbers are hospitalised in the participating centres then it may be possible to randomise several thousand with mild disease and a few thousand with severe disease, but realistic, appropriate sample sizes could not be estimated at the start of the trial.

From version 6.0 of the protocol, a factorial design will be used such that eligible and consenting participants may be randomised to one of the treatment arms in Randomisation A and, simultaneously, to one of the treatment arms in Randomisation B.

Randomisation part A: Eligible patients will be randomly allocated between the following treatment arms (although not all arms may be available at any one time):

No additional treatment: There are currently no approved anti-viral or host- directed treatments for COVID-19.

Lopinavir-ritonavir: Lopinavir is a human immunodeficiency virus 1 (HIV-1) protease inhibitor, which is combined with ritonavir to increase lopinavir’s plasma half-life. Lopinavir-Ritonavir has shown activity against SARS and MERS CoVs.

Low dose corticosteroids: Favourable immune response modulation by low-dose corticosteroids might help treat severe acute respiratory coronavirus infections, including COVID-19, SARS and MERS.

Hydroxychloroquine: Hydroxychloroquine, a derivative of chloroquine, has been used for many decades to treat malaria and rheumatological diseases. It has antiviral activity against SARS-CoV-2 in cell culture.

Azithromycin: Azithromycin is a macrolide antibiotic with immunomodulatory properties that has shown benefit in inflammatory lung disease.

Randomisation part B: Simultaneously, eligible patients will be randomly allocated between the following treatment arms (provided there are no contraindications and the appropriate consent has been given):

No additional treatment: There are currently no approved anti-viral or host- directed treatments for COVID-19.

Convalescent plasma: Plasma from patients who have recovered from SARS- CoV-2 infection may contain antibodies that can bind to and neutralise the virus. Infusion of convalescent plasma containing high concentrations of neutralising antibody may accelerate clearance of the virus and clinical improvement.

1.2.2 Second randomisation for patients with progressive COVID-19

No additional treatment: There are currently no approved immunomodulatory or other host-directed treatments to prevent the progression of COVID-19.

Tocilizumab (ACTEMRA): Tocilizumab is an interleukin-6 (IL-6) receptor antibody, which blocks a component of the immune response that may drive progression to ARDS.

Outcomes: The main outcomes will be death, discharge, need for ventilation and need for renal replacement therapy. For the main analyses, follow-up will be censored at 28 days after randomisation. Additional information on longer term outcomes may be collected through review of medical records or linkage to medical databases such as those managed by NHS Digital and equivalent organisations in the devolved nations.

PUBLISHED INFORMATION

Effect of Dexamethasone in Hospitalized Patients with COVID-19: Preliminary Report

Peter Horby, Wei Shen Lim, Jonathan Emberson, Marion Mafham, Jennifer Bell, Louise Linsell,NatalieStaplin,Christopher Brightling, Andrew Ustianowski, Einas Elmahi, Benjamin Prudon, Christopher Green, Timothy Felton, David Chadwick, Kanchan Rege, Christopher Fegan, Lucy C Chappell, Saul N Faust, Thomas Jaki, Katie Jeffery, Alan Montgomery, Kathryn Rowan, Edmund Juszczak, J Kenneth Baillie, Richard Haynes, Martin J Landray, RECOVERY Collaborative Group

doi: https://doi.org/10.1101/2020.06.22.20137273

This article is a preprint and has not been certified by peer review [what does this mean?]. It reports new medical research that has yet to be evaluated and so should not be used to guide clinical practice.

Abstract

Background: Coronavirus disease 2019 (COVID-19) is associated with diffuse lung damage. Corticosteroids may modulate immune-mediated lung injury and reducing progression to respiratory failure and death.

Methods: The Randomised Evaluation of COVID-19 therapy (RECOVERY) trial is a randomized, controlled, open-label, adaptive, platform trial comparing a range of possible treatments with usual care in patients hospitalized with COVID-19.

We report the preliminary results for the comparison of dexamethasone 6 mg given once daily for up to ten days vs. usual care alone. The primary outcome was 28-day mortality.

Results: 2104 patients randomly allocated to receive dexamethasone were compared with 4321 patients concurrently allocated to usual care. Overall, 454 (21.6%) patients allocated dexamethasone and 1065 (24.6%) patients allocated usual care died within 28 days (age-adjusted rate ratio [RR] 0.83; 95% confidence interval [CI] 0.74 to 0.92; P<0.001). The proportional and absolute mortality rate reductions varied significantly depending on level of respiratory support at randomization (test for trend p<0.001): Dexamethasone reduced deaths by one-third in patients receiving invasive mechanical ventilation (29.0% vs. 40.7%, RR 0.65 [95% CI 0.51 to 0.82]; p<0.001), by one-fifth in patients receiving oxygen without invasive mechanical ventilation (21.5% vs. 25.0%, RR 0.80 [95% CI 0.70 to 0.92]; p=0.002), but did not reduce mortality in patients not receiving respiratory support at randomization (17.0% vs. 13.2%, RR 1.22 [95% CI 0.93 to 1.61]; p=0.14).

Conclusions: In patients hospitalized with COVID-19, dexamethasone reduced 28-day mortality among those receiving invasive mechanical ventilation or oxygen at randomization, but not among patients not receiving respiratory support.

Concluded.

https://www.recoverytrial.net

https://www.recoverytrial.net/files/recovery-protocol-v6-0-2020-05-14.pdf

https://www.recoverytrial.net/files/recovery_dexamethasone_statement_160620_v2final.pdf

https://www.medrxiv.org/content/10.1101/2020.06.22.20137273v1

The RECOVERY Trial – Blog Post #346 by Asrar Qureshi Dear Colleagues! This is Pharma Veterans Blog Post #346. Pharma Veterans welcomes sharing of knowledge and wisdom by Veterans for the benefit of Community at large…

0 notes

foursprout-blog · 7 years

Text

Learn a Language Online and on Your Own

New Post has been published on http://foursprout.com/happiness/learn-a-language-online-and-on-your-own/

Learn a Language Online and on Your Own

You’re reading Learn a Language Online and on Your Own, originally posted on Pick the Brain | Motivation and Self Improvement. If you’re enjoying this, please visit our site for more inspirational articles.

First the bad news. I’m not going to tell you learning a language is easy, it isn’t. Anyone who tells you otherwise is probably selling you something . You may be able to “speak” a language in a few months, but if you want to reach a level where you can read, work, live and study in the language, it’s going to take longer. For most languages, the time to become truly fluent is five months to a year of dedicated study. For English speakers, check out the Foreign Service Institute’s guide if you’re curious about where your language falls.

Hopefully, you didn’t stop reading, because there is a lot of good news. Can you think of a more useful skill that virtually anyone can acquire in six months? I did it, and I’m not being falsely modest about my abilities, either. I was awful at French in high school, I mean really really bad. No blaming the class either, the teacher was great. Everyone else in that school learned French, just not me. Despite this, I later decided to learn Spanish for my career and spent six months in Guatemala. It was intense, but after six months I understood a completely new culture, could communicate with millions of people throughout the world, and read and write well enough to enter a Latin American Literature graduate program at the University of Delaware.

More good news, you no longer have to live abroad to immerse yourself in a language. Everything you need to practice is online and probably free.

Getting Started

Get a textbook or at least a grammar guide. I know it isn’t sexy, and I know new commercial textbooks are ridiculously expensive, but you need something to explain how to form the past tense, if the adjective goes before or after the noun, etc. Besides, your textbook doesn’t have be new or even commercially sold. Odds are pretty good there’s a free open access book that’s just as good, if not better. Here’s my quick list, but there are many more.

Spanish COERLL Spanish Grammar in Context – http://grammar.spanishintexas.org/ Spanish 001 PSU – https://psu.pb.unizin.org/spanish001fa16/

English/ESL Communication Beginnings – http://open.umn.edu/opentextbooks/BookDetail.aspx?bookId=502 Athabasca University – http://eslau.ca/e.php

French Français interactif – https://www.coerll.utexas.edu/coerll/project/fran%C3%A7ais-interactif Liberté – http://open.umn.edu/opentextbooks/BookDetail.aspx?bookId=194

German Deutsch im Blick – http://coerll.utexas.edu/dib/

The Fun Part

If you’ve read this far, I’ve hopefully convinced you that learning a language requires a major time commitment, and there’s no avoiding learning some basic grammar. Like a lot of things, the hardest part of learning a language is getting started. So you have your textbook and you’ve looked through the introduction, maybe learned greeting or even a few basic sentences, now it’s time practice. Anything you do in a foreign language is helpful, so pick things you enjoy. Just try and be sure to practice all four language skills: listening, speaking, reading and writing.

Listening

Got Netflix? Netflix is our first global on demand TV station, so they have lots of multilingual content, especially their original content. Depending on how you watch, you can either set the language of the audio and subtitles before you start the program or via an icon bottom right after you start.

No Netflix, no worries. The web is full of sitcoms from around the world. Sneer if you like, there’s no better language learning tool than a predictable yet enjoyable sitcom. If you’re learning German, search for MediaThek. Otherwise YouTube is the way to go, search for “Episode” in your language of choice and filter for length.

Youtube: English, French and Spanish (includes results in Portuguese, too)

MediaThek ARD, I enjoy “Tatort”, Google MediaThek for other German channels.

Speaking

Find a language partner. Especially for English speakers, you shouldn’t have any trouble finding someone who is looking to practice their English in exchange for equal time helping you. At Dickinson College, we created “The Mixxer”. We use it for our own students, it’s completely free and pretty self-explanatory.

Reading

The whole web, whatever you like. If you’re just beginning, you may want a little help, though. There are several plugins that will translate a word with one click. Google Translate (free), Readlang (free but limited), and Word Reference all have one. I prefer Word Reference since it provides a dictionary definition. Your call.

Writing

Remember “The Mixxer”? It has a writing section, too. Write a paragraph or two, submit, and a native speaker will correct it. Return the favor and correct someone writing in your native language. You can also send written messages back and forth if you prefer a penpal.

Todd Bryant is the language technology specialist at Dickinson College. You can follow him on Twitter @bryantt

You’ve read Learn a Language Online and on Your Own, originally posted on Pick the Brain | Motivation and Self Improvement. If you’ve enjoyed this, please visit our site for more inspirational articles.

#Happiness

0 notes