#avigna clinical research

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Avigna Clinical Research Institute | BES Online

Avigna Clinical Research Institute [ACRI], Bangalore plays a vital role in providing a good platform for students. Know more about ACRI admission 2023, fees structure, procedure, college code. Admissions open!https://www.besonline.in/avigna-clinical-research-institute-acri-bangalore.html

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PV Mock Sessions@ ACRI India See More@ www.acriindia.com #ACRIIndia #ClinicalResearchInstituteBangalore #OnlineClinicalResearchInstitute #AvignaClinicalResearch

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Career options after M.B.B.S,BDS: Clinical research refers to the process, which is basically the evaluation of how effective or useful a new drug, vaccine, diagnostic test, new device or surgical technique, can be in humans.

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Avigna Clinical Research Institute

Avigna Clinical Research Institute

Avigna Clinical Research Institute Bengaluru, Karnataka. Avigna Clinical Research Institute (ACRI) is one of the most premium, innovative, and top clinical research institutes in Bangalore that is situated in the peaceful outskirts of the city, dedicated to providing excellent PG diploma clinical research in Bangalore. With the robust curriculum that the institute provides, along with immense…

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Will The World Achieve SDGs? India Will Tell!

India has found immense success in fighting life-threatening diseases like tuberculosis, malaria, lymphatic filariasis, and more. With such success, the country is all set to play a vital role in determining whether new drugs, vaccines, and other prevention tools can be deployed effectively and affordably to eliminate all such diseases from the world! This amazing news has been declared by the Bill & Melinda Gates Foundation. India will play an important role in determining whether Sustainable Development Goals (SDGs) can be achieved. This was confirmed at a lecture organized by the Department of Biotechnology, Biotechnology Industry Research Assistance Council, and the AIIMS. This is all thanks to the amazing education and training that is provided by reputed institutes across the country. You can also attain such exclusive training at Avigna Clinical Research Institute, the best clinical research online training institute in Bangalore. So, if clinical research and healthcare is your passion, enroll yourself right away!

What was the lecture about?

The lecture was titled “Innovating for Impact: How India can lead in helping solve some of the world’s toughest health challenges”. It primarily focused on India’s potential in addressing global health issues, and the challenges and opportunities that lie ahead. This lecture was attended by global leaders from various domains, where they shared their experienced and interacted with the scientific community.

How has this been possible?

This has been possible due to India’s huge size and population that carries a major portion of the world’s disease burden. India thus will play a crucial role in biotechnology and artificial intelligence that will determine the manufacturing of newer tools and technologies, which can help the country achieve health equity, and take leadership in addressing global health challenges. After all, no other country across the world’s emerging economies has the same combination of world-class biomedical research, effective translational research expertise, capacity to design and implement highly powered clinical trials, and capacity to produce health products that meet the stringent regulatory standards of the WHO, other than India!

India and its healthcare challenges

India definitely has 1 million missing cases of tuberculosis, but it also has the opportunity to develop improved solutions for tuberculosis case finding and reporting, along with treatment adherence. Another challenge that the country faces is that of nutrition. But, the National Nutrition Mission has set the goal of reducing the percentage of stunted children from 38.4% to 25% by the end of the year 2022.

ALSO READ: India Has Begun The Clinical Trial Of A New Tuberculosis Vaccine For Adults

India’s collaboration with international partners

India is collaborating extensively with many international partners in new areas to deal with the emerging healthcare challenges. Considering the high costs involved with healthcare, the collaboration is important to be taken up for frugal innovations so that efficient and affordable treatment strategies, relevant to the developing world and emerging markets, can be brought about. After all, access to affordable health technology remains a massive challenge not just in developing countries, but also in the developed ones, where pressure on the healthcare budget is immense.

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Dulaglutide – How Safe Is This Diabetic Medication For Other Body Systems?

Diabetes is one of the most common health issues that people all over the world are encountering. Speaking of India, the country sees 10% of the total population suffering from diabetes. But, the shocking fact here is that almost one in every two Indians living with diabetes is unaware of their condition!

Diabetes is of two types – Type 1 and Type 2; out of which Type 2 is the more common form seen, with 95% of diabetic patients suffering from it. The Type 2 diabetes can be controlled with the help of proper nutrition, exercise, and weight management. But, there are also required certain kinds of medications to be taken often. One drug that is most commonly used to treat this kind of diabetes is Dulaglutide. Founded in 2015, the drug has been commonly prescribed to diabetic patients. However, there were still, until recently, clinical trials going on over the medication to check for its impacts on the urinary and cardiovascular systems.

Advanced clinical trials conducted for testing Dulaglutide

While the medication has been proven to effectively treat diabetes, the doubt was whether it had any negative effect on any other bodily systems like the cardiovascular and urinary tracts. The good news is that the medication has been found to be absolutely safe and effective against cardiovascular and kidney diseases too! The clinical trials being done on the medication involved 9900 people from 24 countries, for more than five long years! Ultimately, it was researched and determined that the drug reduced cardiovascular events and kidney problems in middle-aged and older people. In fact, cardiovascular risks like heart attacks and strokes were reduced by 12% in patients taking Dulaglutide injections, compared to people taking a placebo. The greatest benefit was seen for heart failure, with a risk reduction of more than 30%. In addition, the drug also reduced the possibility of the development of kidney diseases by 15%. Such incredible results can be obtained when our dedicated countrymen take up clinical research as their career option, and undertake professional courses at reputed institutes like Avigna Clinical Research Institute, to learn and obtain a legitimate diploma in Clinical Research Bangalore.

Why were advanced clinical trials conducted?

What made this study to be taken up was the fact that people with diabetes have seen to observe twice the rate of cardiovascular events like heart attacks and strokes, and up to 40% development of kidney diseases, as compared to non-diabetic people. The trial has clearly shown that Dulaglutide can safely reduce the risks of cardiovascular diseases and kidney diseases, while also improving diabetes control, and modestly lowering weight and blood pressure in middle-aged and old patients with Type-2 diabetes.

How does Dulaglutide work?

Dulaglutide is injected once a week in patients suffering from Type-2 diabetes to lower the glucose level in the body. It works by helping pancreas release the right amount of insulin, when blood sugar levels are high, slowing the emptying of the stomach after a meal, and reducing appetite and weight. The drug has shown good tolerance, modest weight reduction, low-density lipoprotein cholesterol and blood pressure, and a modest increase in heart rate. It is easily available in the Indian market, although being a little expensive. However, as long as it keeps your diabetes, heart rate, blood pressure, weight, cardiovascular system, and urinary system under control, there should be no issue paying a little extra for that one dose of injection; should there?

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India Has Begun The Clinical Trial Of A New Tuberculosis Vaccine For Adults

India is home to 1/4th of the world’s tuberculosis burden, which has given the country an opportunity to make huge strides in public health by becoming a global leader in tuberculosis research. Taking this initiative, a vaccine trial was launched on 15th of July 2019 by the Indian Council of Medical Research (ICMR), to prevent occurrence of tuberculosis among close contacts of a tuberculosis patient who are at high risk of contracting the disease.

The new vaccine – Phase-III trials

The most famous BCG vaccine trial had been undertaken decades ago, after which a Phase-III trial is being conducted now for this new vaccine, to come up with the first tuberculosis vaccine for adults, as the BCG vaccine available and tested is only for newborns. This step is a stride towards prevention, which will help in decreasing the burden of the tuberculosis disease. After a detailed landscape analysis of the available lead vaccine candidates, two potential vaccine candidates VPM 1002 and MIP were shortlisted for being taken forward through the Phase-III trial in healthy household contacts of sputum smear positive tuberculosis patient. This clinical trial will evaluate the safety and efficacy of these two vaccines in a single trial, against a control group with no vaccine. The study would enroll 12,000 healthy household contacts of sputum smear positive tuberculosis cases that are at high risk of contracting the disease. These contacts would be from 7 sites in 6 states, namely Delhi, Orissa, Tamil Nadu, Karnataka, Maharashtra, and Telangana. The trial has begun at the first site, and will subsequently be initiated at other sites too, with a goal to complete the enrollment within 7-8 months.

What experts said

Balram Bhargava, Secretary at the Department of Health Research and Director General at ICMR, appreciated the Government’s support and researchers involved in the trial, at the launch of the vaccine’s clinical trial. He said that the clinical trials are needed in India to prove that the vaccine is safe and effective, and can provide protection to Indian populations, where the disease is endemic. The ultimate goal of this trial is to develop a vaccine that can prevent active tuberculosis and be a part of large campaigns aimed at eliminating the disease. The clinical study can thus help in achieving this goal and significantly advance the global fight against tuberculosis.

Rohit Sarin, Director at NITRD, said that this trial is a much awaited one, which is why he promised to provide complete support in timely completion of the procedure. In fact, every statutory regulatory body of India has approved this trial, as per the Indian regulatory guidelines.

You can also become an expert in the field of clinical research by undertaking a professional course of diploma in Clinical Research Bangalore at a reputed institute like Avigna Clinical Research Institute. This will help you achieve a certificate that will bring to you a good job in the field in top CROs, Bio-techs, and pharmaceutical companies.

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How Many Diabetics Are Actually Aware Of Their Condition?

Diabetes is a disease that occurs when your blood glucose goes beyond its limit. The body produces insulin to help the glucose from the food get into your cells so that it can be used for energy. But sometimes, the body doesn’t make enough insulin, which keeps the glucose within the blood itself. Having too much glucose in your blood can cause diabetes as well as many other health problems. Remember, whether your diabetes value is too high, or it is only on the border, every condition and case of diabetes is serious!

India and diabetes

Almost 10% of Indians are suffering from diabetes today; and can you believe it, around one in every two Indians living with diabetes is unaware of their condition! Moreover, only half of those who realize that they have diabetes are able to manage their condition and bring it under control. This means that only 25% of diabetics in India are able to cure, or at the least, maintain their condition!

Variation in health system performance for managing diabetes among states in India – The study

This number of 25 has been brought up only after a good amount of survey and research done. It was a cross-sectional study of individuals aged 15 to 50 years, which was conducted by the PHFI, MDRF, and the Harvard School of Public Health, along with other international organizations. They used secondary data from the National Family Health Survey 2015-16 for the analysis, and concluded what has been mentioned above.

How can diabetes be identified?

Developed countries have their citizens undertake regular health checkups to monitor all their diseases, which even include non-communicable ones. We need to adopt this approach in India too, which will help monitor blood glucose levels, and thus keep a check on diabetes. Otherwise, in India, we only undergo a checkup when a health certificate is required; which is a very wrong practice. This clearly shows that we aren’t undergoing health checkups for our own sake, but only for the sake of clearing a document that can help us achieve something that we may want; like a visa, a job, or the like.

Diabetes is a silent disease, which is why one may not be able to realize that they are suffering from it. But, if you really want to keep a check, you will have to undergo routine health checkups and look for even the slightest symptoms so that they can be treated immediately and more effectively, before they reach a higher stage.

The future of diabetes in India

With the way that India is growing its diabetic population year after year, it seems like it will become the diabetes capital of the world in the next few years! In fact, the International Diabetes Federation has also estimated that by 2045, India will have more than 130 million diabetic patients across the country!

How can diabetes be treated?

Diabetes may, if left untreated, develop harmful cases like kidney problems, which may require transplant or dialysis. While this is a huge problem for the patients themselves, another fact is that we don’t have enough donors for the transplant as well. Moreover, the dialysis may cost at least Rs. 3 lakhs every year, which is almost unaffordable by a major percentage of Indians.

Diabetes can be of two types – one in which the body stops making insulin at all; and the other in which the body cells cannot use blood sugar efficiently for energy. While both these types of diabetes can be controlled with the help of dietary changes and exercise, the first type will require insulin, while the second type will require non-insulin medications. How all of this is found and implied, is all thanks to the hardworking clinical researchers and scientists. You can also become one of these highly esteemed individuals by undertaking professional online clinical research training from a reputed institute like Avigna Clinical Research Institute.

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Clinical Trials Being Taken Up In India For Cholera Vaccines

Cholera is a bacterial infection that causes diarrhea, which kills the patients within hours, if left untreated. If patients are diagnosed in time, and treated with antibiotics and other measures at an early stage, they can recover and get back to their normal lives, but if not, they may have to lose their life! Cholera infects approximately 2.8 million people, causing 95,000 deaths every year! In 2018, there was a global demand for around 100 million doses of cholera vaccine, but the supply was only somewhere around 20 million; so you can imagine the sad face of the outbreak!

Today, the world relies only on two suppliers for cholera vaccines – one from South Korea, and the other from India; but, the global demand for cholera vaccines is higher than the supply. This is why large-scale clinical trials are being planned to be conducted, and a Swedish-designed cholera vaccine is to be commercialized to help fight persistent outbreaks of cholera in India and abroad.

The Hilleman-Bharat pact

It is the Hyderabad-based Bharat Biotech that signed a pact with the New Delhi-based Hilleman Laboratories to speed up the development and clinical trials. Also, the manufacture of the new oral cholera vaccine needs to be accelerated for the drug to be supplied to low and middle income countries. This collaboration of Bharat Biotech and Hilleman Laboratories has been mainly done to address the global shortage of cholera vaccines, in the midst of the persistence of outbreaks in several states across India and Africa.

What is the pact about?

Under the pact, Hilleman laboratories have licensed to Bharat Biotech the vaccine designed by scientists at the University of Gothenburg, Sweden. The vaccine’s safety and capacity to produce an immune response to cholera has already been established by Hilleman laboratories through limited Phase-1 and Phase-2 clinical trials in Bangladesh. Bharat Biotech, thus, has to conduct larger Phase-3 trials and scale up the vaccine production process for commercialization, while also seeking a pre-qualification certification from the World Health Organization, to enable it to supply the vaccine through global funding agencies. The entire process may take somewhere around three years, but the capacity to deliver 50 million doses every year will resolve the uncertainty over supply.

Cholera widespread in India

In India, the highest risk of cholera is in Bengal. In fact, Ancient Asiatic cholera strains have also thrived in the Ganges delta, making Bengal very unsurprisingly the most highly affected state. In fact, almost 50% of cholera cases seen in India every year have been in Bengal. Next in line come Karnataka, Gujarat, Maharashtra, Punjab, Odissa, and Assam. With a goal to produce an affordable vaccine that improves access to millions of cholera patients not only in India, but worldwide too, the vaccine that is being tested could be a key tool in the Narendra Modi government’s Swachh Bharat Abhiyaan campaign, which seeks to improve the levels of sanitation, and the access to clean drinking water.

Get yourself the best quality online clinical research training from Avigna Clinical Research Institute to establish a career in the clinical research industry, so that even you can put in your efforts and inputs to help your country, and the entire world, fight many such conditions like the life-threatening cholera! And, if you are worried about the associated expenses, worry not, the Indian Government has launched a scheme called SPARC, wherein the government will fund interested clinical research students and give them a chance to work in at least 28 global universities!

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The Journey Of A Medicine – From The Mind To The Shelf

We all have been prescribed one or the other medication by a doctor. It could be an oral medicine, a syrup, an injection, or a vaccine. Whatever it is, all we do is get to the pharmacist, give him the prescription, buy the medicine, and gulp it down as prescribed. While we are undergoing the pain, all we think about is getting well soon; and once we are back to normal, we easily forget about the medicine that brought us back to our routine. For us, the pain that we go through while we are on medications is what is important; but, what about the pains that the researchers go through while developing that medicine for us? Have you ever wondered how that medicine was though about, developed, and reached the pharmacist’s shelf?

Well, now that you think about it, the journey of a medicine isn’t easy. It is always kept in doubt until it is approved to be safe, and sanctioned to be packaged and sold. Every medicine passes through a number of procedures called clinical trials to ensure their safety and efficacy. The reason that modern medical advances have helped millions of people live longer and healthier lives is the decades of investment in medical research.

What are clinical trials?

Clinical trials are experiments or observations done on human participants, designed for treating specific conditions or disorders. They generate data on safety and efficacy that are later analyzed by FDA to check whether they are safe and efficacious enough to be approved for market release. Once approved, the medical devices, medications, or injections are produced, packed, and sold. Clinical trial participation is completely voluntary, wherein participants are overseen at all times to ensure that there is fair conduct and no risk to their health because of the trials.

Why are clinical trials important?

Clinical trials can help detect diseases or conditions, and treat them by testing any new device, treatment, or procedure. They may also help to detect and prevent diseases by testing a vaccine. All in all, clinical trials help people control their symptoms and improve their quality of life by providing raised standards of treatment and improving health care.

How are clinical trials conducted?

This is where we come to the main part – how medicines go through their journey from mind to shelf. Once a thought comes into the mind of a researcher, a potential medicine, procedure, or treatment is discovered. These interventions are then tested in animals for pre-clinical studies, which are submitted to the FDA for permission to test in humans, if the test is successful in the case of animals. Once the permission is granted, the medicine undergoes four phases.

Phase 1 – The drug is first tested on a small group of 20-80 participants to evaluate its safety. Also, any side effect is looked for, and an approximate safe dosage is determined at this stage.

Phase 2 – The drug is tested in a larger group of hundreds to determine efficacy and further safety among a larger group of people of all kinds of castes, regions, skin, etc.

Phase 3 – The drug is now tested on thousands of participants for final confirmation of safety and efficacy, comparing it to other commonly used treatments.

Phase 4 – Once all these phases are complete, and the drug is found safe through all of them, the New Drug Application is submitted to the FDA to gain approval for marketing. The FDA undergoes rigorous evaluation and reviews all the information regarding the drug before approving it for marketing.

You can see how clinical trials play an important role in improving the health outcomes in India. And, it is also a lucrative career option for all those interested in medical research. If medical research interests you too, get enrolled with Avigna Clinical Research Institute’s online clinical research training course, and benefit from having a great career in top CROs, Bio-techs, and pharmaceutical companies.

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How Are Poor Sleep And Poor Nutrition Associated?

Diet plays a huge role to determine a person’s health; we all know that. But, do you know that diet can also impact sleep quality? Yes, it’s true! Research has indicated that just one day of eating food low in fiber, but high in unhealthy saturated fat and sugar, can reduce the duration of sleep; thus affecting the physical and mental energy of a person. While poor sleep has been linked to poor nutrition, it is yet unclear why the two may be linked together, which is why research is being done on that aspect too.

It is a general rule that adults must sleep for more than seven hours every night to maintain their health. It has been found that people who sleep less than seven hours a day may lack adequate levels of vital nutrients. This is because they generally consume fewer nutrients like vitamin A, vitamin D, zinc, niacin, and more.

Another research has been done determining that a greater number of nutrients have been associated with poor sleep in women than in men. However, this number can be reduced if women take dietary supplements. In fact, any individual with short sleep duration may benefit from improving their intake of nutrients through diet and supplements. As a matter of fact, nutrients, other than affecting sleep quality, also play a role in sleep disorders and trouble falling asleep.

Micronutrients are important for our health; they are those vitamins and minerals that our bodies require, but aren’t produced naturally by the body. As a result, they must be added in our diet. Generally, billions of people suffer from one or the other micronutrient deficiency, which is why nutrients are added into their diet as supplements. Any deficiency of such micronutrients results in disruption of normal bodily functions, which may or may not lead to development of diseases or other problems. So, if you want to eliminate the risk of such sleep disorders and other potential body functioning problems, you must focus on the intake of proper micronutrients for your body. Supplementing with artificial additions to your diet can help fill the nutritional gap in your diet. There have been a number of studies that have demonstrated important roles for micronutrietns in growth, development, disease prevention, healing, sleep, and normal bodily functions. For example, magnesium helps the body produce melatonin, which helps with sleep; and zinc plays a role in sleep regulation.

Whether chronic short sleep causes nutrient deficiency, or nutrient deficiency causes short sleep, is yet to be determined. Whatever it is, the fact is that both sleep and nutrients are interrelated, which is why you must have a good diet full of minerals and vitamins.

Such research and many others are possible with the help and involvement of clinical research professionals across the country and the globe. Join the confederation and take up professional clinical research diploma courses in Bangalore from a reputed institute like Avigna Clinical Research Institute to help your countrymen find all sorts of discoveries and innovations related to health, make your country a better and healthier place to live in.