#axon sl

[goatsludge]

Also got an AXON SL from Unity today since one of my Hot Buttons was dead and they were willing to RMA it.

While not as streamlined as a Hot Button, it is growing on me.

More importantly, the crane plug is nice and tight (the WADSN hot button crane plugs have a super weak grip).

[explodingsillycat]

gang i’m bouta go on a big fat ramble about miracle musical art of MY interpretation that makes no sense cuz i can

CW!: Mention of st*bbing (a), unsettling thoughts (?), small mention of animal sl*ughter (a), small mention of D*vil (e), implications of insanity (?)

Stella + Simon :]

1: Stella!!1 - Inside her head during “Murders” (Conceptualized Art of her thoughts/brain, kinda)

-Swirls, Spinning, Dizzying, Dark

She’s so confused, her head reeling, a blur almost. Why would he say such confusing, terrifying things? Going on about how if they die together, then they’ll be together forever! Where was the sweet, charming man who always reassured her, comforted her, who loved her?!

Did he get lost in the forest?

Why was he talking so fast? His words nearly gumbling together, why does he look so hysterical?! His voice was flat, almost emotionless, yet quick, panicked almost.

She was terrified. Maybe the most she’s ever been in her life. What a strange thing, your emotions being heighten around your love. Never would she imagine she’d make her feel so scared. It’s suppose to be that he makes her so much more happy.

She tried to look into his eyes - it was difficult with the dark shadows in contrast to the bright moon.

His eyes were only darting all over her, tracking every single movement she made. Was he aware she was so terrified?!

Yes.

“We must. It’s necessary. We must be together. Together. Together forever.”

???????

Why would the love of her life stab her?

2: Simon!!1! - Inside the Mind of Simon (Ta—💥💥) during “The Mind Electric” (Same Thing W/ Stellaaa)

-Scattered Sparks, Electric Line (idk gang look at the photo), Dark, Sharp

Where Am I? Where is he? Where were they? Who are they? Who is he? What is this?

Where is She?

Are you an animal? A pig to the slaughter?

Where am I? Am I even here?

He was so confused, scared—

What is this on my head?

I DON’T KNOW WHAT’S WRONG WITH ME

.ESAELP ,EM PLEH

Who am I?

Please, I didn’t want to. I didn’t mean to.

“AXON DENDRITE Help Me! AXON DENDRITE Help Me! AXON DENDRITE Help Me!”

SEE.

“Electroconvulsive therapy (ECT for short) is a treatment that involves sending an electric current through your brain.”

Save (me) us.

Stella, my love, I am truly sorry. Forgive me.

H u m m i n g

“It’s the devil! The devil is within that boy!”

Why?

[weaponland]

Новый переключатель AXON SL

Компания Unity Tactical представила на рынке AXON™ SL — это самый маленький однокнопочный дистанционный переключатель оружейных аксессуаров с электрическим питанием. Переключатель крепится непосредственно на рельсы M1913. Кнопка AXON™ SL расположена на лицевой стороне под углом 45 градусов, под которым ее очень удобно активировать. AXON SL стало намного проще использовать при неблагоприятных условиях окружающей среды. ... Читать дальше »

[techcrunchappcom]

New Post has been published on https://techcrunchapp.com/tech-moves-zillow-co-founder-joins-palantir-board-hootsuite-names-new-ceo-and-more/

Tech Moves: Zillow co-founder joins Palantir board; Hootsuite names new CEO; and more

Former Zillow CEO Spencer Rascoff. (GeekWire Photo / Kevin Lisota)

— Zillow Group co-founder and former CEO Spencer Rascoff joined the board of Palantir Technologies, a big data company backed by PayPal co-founder Peter Thiel.

The notoriously secretive Silicon Valley startup filed for an IPO this week. Journalist Alexandra Wolfe Schiff and early Palantir employee Alexander Moore, who is now a partner at 8VC, were also appointed to the board.

Rascoff, who stepped down as CEO of Zillow in early 2019, resigned from the Seattle-based real estate company’s board in April. He also stepped down from the board of Trip Advisor. Rascoff is an angel investor, co-founder of Los Angeles-based tech news venture dot.LA and working on a new stealth startup, according to a post on Twitter. (GeekWire is a dot.LA partner and investor.)

— Vancouver, B.C.-based social media management platform Hootsuite named Tom Keiser as its new CEO. He succeeds Hootsuite founder Ryan Holmes, who will remain chairman of the board. Keiser was most recently COO of CRM software company Zendesk. He led technology and product operations at retailers Gap Inc and L Brands, and spent more than a decade as a consultant at EY.

Arvin Patel. (Intellectual Ventures Photo)

— Intellectual Ventures named former TiVo executive Arvin Patel as chief operating officer of the Bellevue, Wash.-based patent holding and technology company’s Invention Investment Fund. Founded by former Microsoft CTO Nathan Myhrvold, Intellectual Ventures is one of the world’s largest patent holders. Patel was chief intellectual property officer at TiVo and has held IP roles at Technicolor and IBM.

Adriana Gil Miner.(Qumulo Photo)

— Seattle hybrid cloud storage startup Qumulo appointed Adriana Gil Miner as its chief marketing officer. Miner was most recently SVP of brand marketing and communications at Tableau Software. She previously served as CMO at strategy and design firm Artefact and was vice president of digital strategy at Weber Shandwick.

— Investor and advisor Betsy Atkins joined the board of Bellevue, Wash. contract management startup Icertis. Atkins is the CEO and owner of venture capital firm Baja Corp. She currently serves on the boards of Volvo Cars, Wynn Resorts and SL Green Realty. Last year, Icertis’ valuation pushed past $1 billion. The company is currently ranked No. 5 on the GeekWire 200 index.

— Tax automation company Avalara appointed Kathleen Weslock as its new chief human resources officer. Weslock previously led human resources at lithium technology company Livent, Frontier Communications and Cisco Systems. Scott McFarlane, CEO of Avalara, describes Weslock as “a proven human resources leader who has successfully managed and scaled talent programs for some of the world’s most well-known global companies.”

— Entrepreneur Brian Glaister joined Axon as head of justice solutions, a new digital business unit for the law enforcement technology company. Glaister was most recently managing director at startup consultancy Conflux Innovations. He was previously an entrepreneur in residence at Itron and Intellectual Ventures, and founded Cadence Biomedical, a medical device startup.

Brian Smith. (GBH Insights Photo)

— Former Microsoft marketing manager Brian Smith is now senior vice president at New York-based marketing consultancy GHB Insights. At Microsoft, Smith helped with the worldwide launch of Windows 10 Pro and led go-to-market strategy for the Windows tablet launch. Smith most recently was SVP of behavioral analytics at PSB, a market research consultancy based in Washington, D.C. He will be based in Seattle.

— Shahar Ronen has joined Remitly as principal product manager for the Seattle startup’s new banking service called Passbook. The banking initiative, specifically designed for immigrants, launched in February this year. Ronen joins Remitly from San Francisco, Calif.-based Sift, a fraud prevention company, where he was a group product manager. He previously spent five years at Microsoft, where he was a product manager for Bing and MSN Analytics.

— Microsoft alum Rahul Auradkar was named chief product officer of New York-based financial technology platform Capitolis. Auradkar was chief product officer of Seattle AI startup AnswerIQ, which was acquired by Freshworks earlier this year. He previously was vice president of products at Apptio. While at Microsoft he worked on the Azure, Office 365 and Windows server teams. He will relocate to New York.

— Cambia Grove announced its 2020 Innovator Fellows. The program’s second cohort is focusing on data in digital health care transformation. The Fellows are:

• Michael Barabe, Washington State Health Care Authority

• Mark Francis, Electronic Caregiver

• Jen Garcia, Seattle Children’s Hospital

• Tyrone Grandison, Pearl Long Term Care Solutions

• Doan Ha, Oregon Health and Science University

• Aju Jacob, BlueCross BluShield of Tennessee

• Josephy Kliegman, Cerner

• Phung Matthews, MedQuest Pharmacy

• Dayanand Sharma, The Handoff Company

• Kevin Williams, HealthTech Solutions

— RFID maker Impinj promoted Jeff Dossett to chief revenue officer. Dossett originally joined the Seattle-based company in 2017 and was most recently EVP of sales and marketing. He was previously the CEO of media company GOOD Worldwide and served as head of partnerships and interim CFO at Seattle startup Porch.

— Ideoclick, a Seattle e-commerce startup, promoted Jonathan Ferrell to vice president of business development. He joined the 11-year old company in 2019 as senior manager of business development. Prior to Ideoclick, Ferrell was a sales manager at Amazon and spent a decade at Verizon in retail and business sales.

Eric Emans. (Lighthouse Photo)

— Seattle-based Lighthouse eDiscovery hired Eric Emans as CFO. Emans was most recently CFO and treasurer for nonprofit A Place for Mom. Lighthouse makes software that helps lawyers quickly sift through mountains of complex documentation.

— Seattle-based investment bank Cascadia Capital added Adam Stormoen as a managing director for the firm’s healthcare practice. Stormeon was most recently managing director of healthcare investment banking at Duff & Phelps. He will based in Minneapolis, Minn.

— Infrastructure solutions firm HNTB hired Gordon Phillips as its aviation project director. He will be based in Bellevue, Wash. and deliver design projects for aviation clients including Sea-Tac Airport. Phillips most recently was a program design manager at Clay Paslay Management Group working on the 10 year expansion program at Sea-Tac.

— Salesforce named Seattle-area exec Darryn Dieken as its chief availability officer. Read more about the new C-suite role.

— Boeing’s John Mulholland has taken on the role of vice president and program manager for the International Space Station following Mark Mulqueen’s retirement. Read the story.

— Microsoft exec Peggy Johnson was named new CEO of augmented reality startup Magic Leap. Read the story.

— Concur veteran Elena Donio stepped down as CEO of New York City-based Axiom and will return to the West Coast. Read the story.

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[avinmotion]

2019 IBC Show

The IBC Show (2019) is home to Europe’s largest collection of vendors driving the future of media and entertainment. After visiting this years show I’ve made an personal list for the top twenty most innovative and important introductions and announcements.

Top 20

Mk2 Camera Bar (with Intel RealSense) by Ncam

HD-TX 2.4Ghz Transmitter/Recorder by Deity

The Ones W371 Adaptive Woofer by Genelec

TouchMonitor with support for Ravenna AoIP and native AES67 by RTW

Sync Track E Audio Recorder by Tentacle

E2-F8 Full Frame 8K Cinema Camera by Z CAM

PXW-FX9 Full-Frame Camera by Sony

IntelliMix 2 Pro by YellowTec

DIVINE Intelligent Network Audio Monitor (PoE Dante) by Glensound

Orbiter LED Fixture by ARRI

Fleet Quantum Smart Quad Charger by Core SWX

Pocket Cinema Camera 6K (EF) by Blackmagic Design

Blink500 Wireless Audio System by Saramonic

Vison & Cine Series 4K Field Monitors by SmallHD

Prism 4K HEVC Encoder/Decoder Solution (Rack-mount) by Teradek

BM-U173NDI 17.3” 4K NDI Monitor by SWIT

Titan X2 LED Fixture by Rotolight

SX-M2D2 Adaptable Audio Interface by Sonosax

Amaran AL-MC RGB Light System by Aputure

Shark Slider Nano by iFootage

What also caught my eye (alphabetical order)

AJA FS-Mini Frame Synchronizer

AJA HDR Image Analyser 12G

AJA KUMO 6464-12G SDI Router

Angelbird AV PRO CFX (XT) CFexpress Cards

Anton Bauer Dionic 26V Series Batteries

Anton Bauer Titon SL Lithium-ion Batteries

Aputure Amaran MC RGB Light System

ARRI Orbiter

Atomos Shogun Studio 2 Rackmount Recorder

Axon Cerebrum 2.0

Blackmagic Design ATEM Mini

Blackmagic Design BRAW plugin for Adobe Premiere Pro

Blackmagic Design Pocket 6K Camera

Blackmagic Design Video Assist 12G HDR 5” and 7” Monitors/Recorders (with BRAW)

Blackmagic Design Videohub Master Control Pro

Bright Tangerine Misfit Kick (Prototype)

Canon DP-V3120 4K Reference Display

Canon EOS C500 Mark II

Cartoni Maxima 50 Heavy Duty Tripod Head

Cartoni Red Lock Tripod (First Look!)

Core SWX Fleet Quantum Intuitive Smart Quad Charger (with Color Touchscreen)

Core SWX Hypercore NEO 98wh Lithium Ion Battery Pack

Deity HD-TX 2.4Ghz Transmitter/Recorder

Deity S-Mic 2S Short Shotgun Microphone (optimised for use indoors)

DZOfilm LingLung MFT 10-24mm Cine Zoom Lens

Freefly Alta X

Genelec The Ones 8351B coaxial three-ways

Genelec The Ones 8361A coaxial three-ways

Genelec The Ones W371 Adaptive Woofer

Glensound Devine PoE Powered Dante Speaker

Grass Valley Technology Alliance (GVTA)

Hollyland 1000T Wireless Intercom

iFootage Shark Sloder Nano

KineMaster 4.11

LaCie Rugged BOSS SSD

LaCie Rugged SSD & SSD Pro

Lowel EGO LED Light

Manfrotto Advanced2 Camera Bag Collection

Manfrotto Carbon Nano Plus Stand

Manfrotto Carbon Nano Pole Stand

NCAM Mk2 Camera Bar

O’Conner Flowtech Tripod

ORCA OR-268 SoundBag for Zoom F6

Panasonic AJ-CX4000 ENG Camera

Pomfort Livegrade Studio

Pomfort Silverstack Cloud

RED Digital Cinema Ranger Gemini

RED Digital Cinema Ranger Helium

Rotologht Titan X2 LED Light

RTW TouchMonitor - ISA Immersive License

Saramonic Blink500 Wireless Audio System

Sigma Classic Art Primes

SmallHD Cine Series - 4K High-Bright Field Monitors

SmallHD Vison Series - 4K HDR Reference-Grade Field Monitors

Sonosax SX-M2D2 Adaptable Audio Interface

Sony Cinema Lens - FE C 16-35mm T3.1 G

Sony PXW-FX9 6K Full-Frame Camera 

Sony PXW-Z750 Camcorder

Sound Devices 833 Mixer/Recorder

Sound Devices MixPre Series II

SWIT BM-U173NDI 17.3” 4K NDI Monitor

Tentacle Sync Track E Audio Recorder

Teradek Bolt 4K MAX

Teradek Orbit PTZ

Teradek Orbit Wireless Video System

Teradek Prism 4K HEVC Encoder/Decoder Solution (rack-mount)

Wooden Camera 26V Sharkfin Power solution

Wooden Camera Power Solution for Small Cameras (Prototype)

XEEN CF Cine Prime Lens Series (Carbon Fiber)

YellowTech IntelliMixer Pro

YellowTech iXm Podcaster

Z CAM E2-S6 (MFT mount and SpeedBooster Support)

Z CAM ZRAW (macOS Workflow in the future)

Zoom F6 Audio Recorder (with Sennheiser AMBEO Support)

SmallHD Cine 7 Camera Control Kit for RED DSCM2

[nuarcstudio]

SL Axon Structure

[tumimmtxpapers]

Immune mediated neuropathy following checkpoint immunotherapy.

Related Articles Immune mediated neuropathy following checkpoint immunotherapy. J Clin Neurosci. 2017 Nov;45:14-17 Authors: Gu Y, Menzies AM, Long GV, Fernando SL, Herkes G Abstract Checkpoint immunotherapy has revolutionised cancer therapy and is now standard treatment for many malignancies including metastatic melanoma. Acute inflammatory neuropathies, often labelled as Guillain-Barre syndrome, are an uncommon but potentially severe complication of checkpoint immunotherapy with individual cases described but never characterised as a group. We describe a case of acute sensorimotor and autonomic neuropathy following a single dose of combination ipilimumab and nivolumab for metastatic melanoma. A literature search was performed, identifying 14 other cases of acute neuropathy following checkpoint immunotherapy, with the clinical, electrophysiological and laboratory features summarised. Most cases described an acute sensorimotor neuropathy (92%) with hyporeflexia (92%) that could occur from induction up till many weeks after the final dose of therapy. In contrast to Guillain-Barre syndrome, the cerebrospinal fluid (CSF) analysis often shows a lymphocytic picture (50%) and the electrophysiology showed an axonal pattern (55%). Treatment was variable and often in combination. 11 cases received steroid therapy with only 1 death within this group, whereas of the 4 patients who did not receive steroid therapy there were 3 deaths. In conclusion checkpoint immunotherapy - induced acute neuropathies are distinct from and progress differently to Guillain-Barre syndrome. As with other immunotherapy related adverse events corticosteroid therapy should be initiated in addition to usual therapy. PMID: 28765062 [PubMed - indexed for MEDLINE] http://dlvr.it/QSc1fc

[neurogenpapers]

Atlastin regulates store-operated calcium entry for nerve growth factor-induced neurite outgrowth.

PubMed: Atlastin regulates store-operated calcium entry for nerve growth factor-induced neurite outgrowth. Sci Rep. 2017 Feb 27;7:43490 Authors: Li J, Yan B, Si H, Peng X, Zhang SL, Hu J Abstract Homotypic membrane fusion of the endoplasmic reticulum (ER) is mediated by a class of dynamin-like GTPases known as atlastin (ATL). Depletion of or mutations in ATL cause an unbranched ER morphology and hereditary spastic paraplegia (HSP), a neurodegenerative disease characterized by axon shortening in corticospinal motor neurons and progressive spasticity of the lower limbs. How ER shaping is linked to neuronal defects is poorly understood. Here, we show that dominant-negative mutants of ATL1 in PC-12 cells inhibit nerve growth factor (NGF)-induced neurite outgrowth. Overexpression of wild-type or mutant ATL1 or depletion of ATLs alters ER morphology and affects store-operated calcium entry (SOCE) by decreasing STIM1 puncta formation near the plasma membrane upon calcium depletion of the ER. In addition, blockage of the STIM1-Orai pathway effectively abolishes neurite outgrowth of PC-12 cells stimulated by NGF. These results suggest that SOCE plays an important role in neuronal regeneration, and mutations in ATL1 may cause HSP, partly by undermining SOCE. PMID: 28240257 [PubMed - in process] http://dlvr.it/NVhzJK

[nuarcstudio]

SL Facade Axon

[neurogenpapers]

Mfn2 Protects Dopaminergic Neurons Exposed to Paraquat Both in vitro and in vivo: Implications for Idiopathic Parkinson's Disease.

PubMed: Related Articles Mfn2 Protects Dopaminergic Neurons Exposed to Paraquat Both in vitro and in vivo: Implications for Idiopathic Parkinson's Disease. Biochim Biophys Acta. 2017 Feb 16;: Authors: Zhao F, Wang W, Wang C, Siedlak SL, Fujioka H, Tang B, Zhu X Abstract Mitochondrial dynamics and quality control plays a critical role in the maintenance of mitochondrial homeostasis and function. Pathogenic mutations of many genes associated with familial Parkinson's disease (PD) caused abnormal mitochondrial dynamics, suggesting a likely involvement of disturbed mitochondrial fission/fusion in the pathogenesis of PD. In this study, we focused on the potential role of mitochondrial fission/fusion in idiopathic PD patients and in neuronal cells and animals exposed to paraquat (PQ), a commonly used herbicide and PD-related neurotoxin, as models for idiopathic PD. Significantly increased expression of dynamin-like protein 1 (DLP1) and a trend towards reduced expression of Mfn1 and Mfn2 were noted in the substantia nigra tissues from idiopathic PD cases. Interestingly, PQ treatment led to a similar changes in the expression of fission/fusion proteins both in vitro and in vivo which was accompanied by extensive mitochondrial fragmentation and mitochondrial dysfunction. Blockage of PQ-induced mitochondrial fragmentation by Mfn2 overexpression protected neurons against PQ-induced mitochondrial dysfunction in vitro. More importantly, PQ-induced oxidative damage and stress signaling as well as selective loss of dopaminergic (DA) neurons in the substantia nigra and axonal terminals in striatum was also inhibited in transgenic mice overexpressing hMfn2. Overall, our study demonstrated that disturbed mitochondrial dynamics mediates PQ-induced mitochondrial dysfunction and neurotoxicity both in vitro and in vivo and is also likely involved in the pathogenesis of idiopathic PD which make them a promising therapeutic target for PD treatment. PMID: 28215578 [PubMed - as supplied by publisher] http://dlvr.it/NS7q04