#erviti

[secondskin007]

"64. Imanol Erviti (ESP) & 65. Mikel Landa (ESP)" by charles.jacques is licensed under CC BY-SA 2.0.

[yi-chiao-wang-blog]

在不來。4/26後 版權到期。就沒任務解了 。 #Kawasaki#zrx1200r#zrx1200#zrx1200daeg #zrx1200s #zrx1200ダエグ #川崎重工#男子漢#zrx1200bratstyle #beetracing #shoei#kagayama#dainese #erviti #亞駒重車騎士館#galespeed #naps#ohlins#mracing#magicalracing #brembo#tokico#台大重車（在 硨銪 - 智能刷卡室內自助洗車場） https://www.instagram.com/p/BwkLZGwAvV-/?utm_source=ig_tumblr_share&igshid=15mzcd2pxncu8

[pcwt]

Imanol Erviti received no fractures following his incident on Stage 1 of the  #Dauphiné, but received numerous stitches across his right side following the strong blow suffered in the neutralization zone. After trying to carry on for 30km, severe pain forced him to abandon.

[mednerds]

How extracellular vesicles can enhance drug delivery

By Amanda B. Keener (Nature). Illustration: David Parkins

In exosomes, our bodies have an efficient means of transmitting RNA information. Researchers want to use it to deliver drugs.

When Lydia Alvarez-Erviti started her postdoctoral studies at the University of Oxford, UK, in 2008, her goal was to develop gene therapies for neurodegenerative diseases. She had identified her target — α-synuclein, a protein that accumulates in the brains of people with Parkinson’s disease — and designed a short interfering RNA (siRNA) to reduce the amount of α-synuclein made in mice. But she needed to get the siRNA into the brain. The method would have to protect the RNA, cross the barrier between circulating blood and the brain, and be safe enough to use repeatedly. Fortuitously, a colleague had begun studying something that could work — naturally occurring, nano-sized vesicles called exosomes.

Exosomes are 30–100-nanometre-wide lipid spheres that are used by cells throughout the body to transfer small molecules such as microRNA (miRNA). Optimized to travel in the body without attracting undue attention from the immune system, each tiny package is “an ideal drug carrier”, says Juliane Nguyen, a bioengineer at the University of North Carolina at Chapel Hill.

Around ten years ago, Alvarez-Erviti, who is now at the Center for Biomedical Research of La Rioja, Spain, and her colleagues proved exosomes’ potential as drug carriers in a mouse model of Parkinson’s disease. Now, a large body of a work in animals, along with early studies in people, has demonstrated the proficiency and safety of exosome products.

Exosomes are expensive to isolate from other types of extracellular vesicle (EV), and they naturally carry diverse, often uncharacterized, material. In terms of safety and standardization, these complexities place exosome-based therapies somewhere between cell therapy and treatment with small-molecule drugs. But these challenges have not deterred Alvarez-Erviti’s team or the other research groups and companies working to standardize and scale up EVs for use in people. “When you work with exosomes,” she says, “you need to have to have a lot of gumption.”

The natural alternative

For RNA and small-molecule drugs, getting inside cells is a major bottleneck for reaching targets. The body has measures in place to keep foreign material out of cells, including cell membranes and RNA-degrading enzymes. Biotechnologists have come up with various workarounds. Synthetic nanoparticle carriers or empty viruses, for example, are often used to protect drugs from degradation and to promote their entry into cells. Among the most popular carriers are liposomes — spheres of lipid molecules, usually 100–200 nanometres in diameter, that can fuse with the cell membrane to deliver their cargo. But in high doses, liposomes can damage cells, and both liposomes and viral carriers can trigger immune reactions after repeated administration. These drawbacks have led many to consider exosomes as carriers — the RNA transport service that the body already has in place.

Exosomes are regarded as safer than artificial vesicles because they already circulate through the body. Researchers have found that exosomes can be administered to cells in the lab without causing cell death, and repeatedly injected into mice without causing inflammation. Alvarez-Erviti harvests exosomes from immature immune cells because vesicles from these cells don’t have immune-activating molecules on their surfaces. Exosomes from mesenchymal stem cells are also popular because stem cells tend to avoid immune detection.

Like most nanoparticle drug carriers, exosomes accumulate mainly in the liver, lungs and spleen. But they also show an affinity for the tissues they were originally collected from. Bioengineer Ke Cheng at North Carolina State University in Raleigh found that when exosomes harvested from fibrosarcoma cells are injected into tumour-bearing mice, the vesicles are drawn to the tumors.

This homing characteristic means exosomes can deliver more of the drug to where it is needed, reducing the potential for side effects. Cheng’s team reported that loading a liposome-based chemotherapy drug called doxorubicin into cancer-cell exosomes increased the amount of the drug that reached the tumours. Treatment with exosome-encased doxorubicin also shrank the tumours to a greater degree than did doxorubicin alone.

Vesicles from some non-cancerous cells also have useful homing abilities. According to Steven Stice, a stem-cell biologist at the University of Georgia, Athens, and co-founder of nearby biotechnology company Aruna Bio, exosomes from a human neuronal stem-cell line called AB126 cross the blood–brain barrier and home in on sites of injury. And some researchers are engineering exosomes to increase their retention in certain tissues. For example, Alvarez-Erviti’s team genetically engineered cells to produce exosomes bearing rabies-virus proteins on their surface and that caused the vesicles to accumulate in the brain where the receptor for the protein is found.

Peptides that direct vesicles to desired tissues can also be chemically linked to exosome surface proteins or embedded into vesicle membranes — an approach that could speed up their preparation in clinical settings. Cheng’s team, for example, used a commercially available phospholipid reagent to slip a peptide known to home to heart cells into exosome membranes. This increased exosome accumulation in the hearts of rats induced to have heart attacks.

Controlling the contents

When Alvarez-Erviti began to work with exosomes, she already had a therapeutic molecule for them to carry. But EVs are naturally filled with proteins, RNAs and lipids. Although their biological activity is largely uncharacterized, some seem to be therapeutic in their own right.

Researchers are working to identify the therapeutically active molecules inside exosomes and use them in new treatments. Cheng’s team has found a human exosomal molecule, called miRNA-21-5p, that reduces the rate of heart-muscle cell death and improves blood-vessel growth and tissue repair after heart attacks in mice. The team’s long-term goal is to generate exosomes with high levels of the miRNA and a cardiac cell homing peptide. These superexosomes, as Cheng calls them, would be administered through the bloodstream immediately after a heart attack.

One way to load EVs with therapeutic cargo is to disrupt vesicle membranes with electrical current or chemicals to allow drugs to enter. Another option is to genetically engineer vesicle-forming cells to make an RNA or protein drug before vesicle formation. However, there’s no guarantee that an engineered cell will load the desired cargo into its vesicles. “The cells decide what to encapsulate,” says Young Kwon, a biomedical and materials scientist at the University of California, Irvine.

Nguyen’s team is studying how cells make those decisions, to find ways to ramp up exosome loading with artificial cargo. Researchers have identified strands of code common in natural exosomal RNAs that probably play a part in packaging the molecules. And Nguyen has found that copying some of these molecular codes onto other RNAs increases their loading into exosomes by up to 100-fold. She plans to use the technology to load breast cancer exosomes with miRNAs that block blood-vessel formation and cancer spread.

Another route to control vesicle content is to force their formation through physical or chemical manipulation of cells. Kwon’s team chemically coaxes cells to pinch off membrane-bound pieces of themselves called blebs that, compared with naturally occurring EVs, are more homogeneous in size and content. Any RNA made by a cell should be distributed into the blebs randomly. Such cells can be made to produce ten times as many blebs as they can vesicles — and in hours instead of days.

A new biologic

EVs are challenging to turn into commercial products for the same reason that they have so many advantages — they have to come from living cells. Most companies are using a few well-characterized cell lines to produce all their exosomes. Stem cells are a natural choice, because they can be cultured for a long time and do not produce an immune response. Cells produce the most exosomes when grown in suspension rather than on a flat surface, says Jan Lötvall, who studies exosomes at the University of Gothenburg, Sweden. But stem cells must adhere to something to grow, so some companies use spherical microcarriers suspended in media — an approach that can increase exosome production 20-fold.

Firms also need to improve methods for purifying EVs from cell-growth media on a large scale — much bigger than in academic labs. Lötvall says that manufacturing issues such as these are surmountable, but will make EVs an expensive option for delivering therapies. There is also no clear path to approval yet. Cheng says drug regulators such as the US Food and Drug Administration have yet to release guidance on how these vesicles can be tested for safety and potency. For now, researchers and companies test them batch by batch, each using different assays depending on the drug they’re developing.

Creating artificial exosomes could sidestep these challenges. But researchers still need to work out how exosomes are made and why they are so effective at infiltrating cells and evading immune detection. Only after they answer these basic questions will this new mode of drug delivery be ready for clinical service.

[christian-cardoso]

Walter Erviti jugará la próxima temporada para el Club Atlético Alvarado Después del cortocircuito, con Ariel Holan, el jugador de 37 años firmó su incorporación al club del que es hincha.

[elrojoesmipasion]

Holan: "Quiero tener otro delantero de área"

Holan: “Quiero tener otro delantero de área”

Ariel Holan, DT del Club Atlético Independiente dialogó el día de hoy en TyC Sports. Uno de los temas al que se refirió fue la posible venta de Rigoni al Fútbol Europeo.

La falta de recambio fue una de las principales causas por el cual el Rojo no consiguió el objetivo el semestre pasado. El de ingresar a la Copa Libertadores. Por eso, Holan dijo el día de hoy, que: “Quisiéramos tener dos…

[elshowmagazine]

Independiente gustó y goleó a Newell's en el Coloso

Independiente gustó y goleó a Newell’s en el Coloso

Una máquina el Independiente de Holan: le metió cuatro a Newell’s en el Coloso para dejarlo con las ganas de acercarse a Boca, sumó su cuarto triunfo seguido de visitante y llega entonado al clásico de la próxima fecha ante Racing. Gigliotti, dos veces, Rigoni y Bustos, los goles de Independiente. Scocco y Maxi Rodriguez, para el local.

El partido arrancó de la mejor manera para Independiente. En…

[losgoles]

Walter Erviti salió a dar la cara por el plantel de Banfield, que decidió no entrenarse

Walter Erviti salió a dar la cara por el plantel de Banfield, que decidió no entrenarse

Si por algún lado se sufre más la crítica situación del fútbol argentino, es en los clubes que están lejos de la cima de la pirámide. Y no hace falta irse a las instituciones de Ascenso para encontrar situaciones dramáticas: en los clubes chicos de Primera abundan los casos de jugadores -sobre todo los más jóvenes- con serias dificultades para llegar a fin de mes. En Banfield, por ejemplo, la…

[gkdhaka]

Covid sends Froome crashing out of Tour de France

Covid sends Froome crashing out of Tour de France

Four-time champion Chris Froome was one of three riders to drop out of the Tour de France after testing positive for Covid ahead of Thursday’s 18th stage from Lourdes to the High Pyrenees. Spain’s Imanol Erviti of Movistar and Italian Damiano Caruso of Bahrain Victorious also withdrew. “Tests taken just before Thursday’s start showed that Chris has Covid,” Froome’s Israel Premier-Tech team…

[znewstech]

Covid sends Chris Froome crashing out of Tour de France | More sports News

Covid sends Chris Froome crashing out of Tour de France | More sports News

LOURDES (France): Four-time champion Chris Froome was one of three riders to drop out of the Tour de France after testing positive for Covid ahead of Thursday’s 18th stage from Lourdes to the High Pyrenees. Spain’s Imanol Erviti of Movistar and Italian Damiano Caruso of Bahrain Victorious also withdrew. “Tests taken just before Thursday’s start showed that Chris has Covid,” Froome’s Israel…

[eeyc]

Peter Doshi, Juan Erviti et al. Traducción al español de "Serious Adverse Events of Special Interest Following mRNA Vaccination in Randomized Trials"

“Eventos adversos graves de especial interés tras la vacunación covid19 con ARNm en ensayos aleatorios”

El exceso de riesgo de sufrir un evento de salud grave en vacunados (15,1 por 10.000 participantes) supera a la reducción del riesgo de hospitalización por COVID-19.

https://extramurosrevista.com/estudio-universidades-maryland-stanford-ucla-y-navarra-entre-otras-demuestra-que-las-vacunas-no-son-ni-eficaces-ni-mucho-menos-seguras/?fbclid=IwAR0dN5_sq_3x-jPowuSJXz77KYDHzp-TUk-mZch_46zM9R7RwiOl-Cog3aw

[yi-chiao-wang-blog]

再見了。呆呆/笨笨頭！ 。 頭罩2.0更新版... 。 剩下貼紙。就搞定了！ 。 #Kawasaki#zrx1200r#zrx1200#zrx1200daeg #zrx1200s #zrx1200ダエグ #川崎重工#男子漢#zrx1200bratstyle #beetracing #shoei#kagayama#dainese #erviti #亞駒重車騎士館#galespeed #naps#ohlins#mracing#magicalracing #brembo#tokico#台大重車 #重車維修請找小王師傅0928018045 #重車維修請找李小胖師傅0920825862 #重車維修請找阿ken師傅0977247360（在 亞駒重車騎士館） https://www.instagram.com/p/BqZg87ygJZ1/?utm_source=ig_tumblr_share&igshid=1kw8a3t1fr53z

[pcwt]

TOUR’21 Stage 12: Politt Powers To The Solo Win In Nîmes! Pt.2

Solo win for the BORA-hansgrohe rider

Stage 12 was a lumpy and hot day for the Tour de France and there were a lot of tired legs from the ascents of Mont Ventoux on Wednesday. The break of the day took a big lead, (13 minutes) to fight it out for the victory. BORA-hansgrohe’s Nils Politt was the strongest in the front group and went solo after softening up the opposition. Tadej Pogačar (UAE Team Emirates) was happy to finish another day in yellow.

Tour de France Stage 12 Result: 1. Nils Politt (Ger) BORA-hansgrohe in 3:22:12 2. Imanol Erviti (Spa) Movistar at 0:31 3. Harry Sweeny (Aus) Lotto Soudal

Tour de France Overall After Stage 12: 1. Tadej Pogacar (Slo) UAE Team Emirates in 47:22:43 2. Rigoberto Uran (Col) EF Education-Nippo at 5:18 3. Jonas Vingegaard (Den) Jumbo-Visma at 5:32

[korrektheiten]

Anfang vom Impfende: Schwere Erkrankung durch COVID-19-Impfung wahrscheinlicher als durch COVID-19 – Zulassungsbehörde schönt Daten von Pfizer/Biontech/Moderna [neue Studie]

ScienceFiles:»Fangen wir heute einmal etwas anders an: Joseph Fraiman, Louisiana State University, USA Dr Juan Erviti, Navarra Health Service, Spain Dr Mark Jones, Bond University, Australia Dr Sander Greenland, University of California, USA Dr. Patrick Whelan, University of Californa, USA Dr Robert M. Kaplan, Stanford University, USA Dr Peter Doshi, University of Maryland, USA, Herausgeber […] http://dlvr.it/SSfNCq «

[architectnews]

The 20th ASCER Tile of Spain Awards Winners

The 20th ASCER Tile of Spain Awards Winners, Architecture-Interior Design Prize, Buildings Images

Winners of the 20th ASCER Tile of Spain Awards

International Architectural Prizes – Building & Architect News

28 Jan 2022

The 20th ASCER Tile of Spain Awards

Tile of Spain announces the prize-winners of its prestigious awards, celebrating the creative use of ceramics in architecture and design

The Tile of Spain awards promote the innovative use of Spanish ceramics in interior design and architecture both in Spain and abroad. Now in its 20th edition, the competition is organised by ASCER, the Spanish ceramic tile manufacturers’ association. The annual awards are regarded as a major global event in the industry, earning its winners a highly respected accolade.

WINNERS First prize in the Architecture category, with a cash award of 15,000 Euros, went to MRM Architects’ Studio (Miguel Alonso Flamarique, Roberto Erviti Machain, Mamen Escorihuela Vitales) for the new headquarters of the Valencia Construction Sector Employment Foundation.

Valencia Construction Sector Employment Foundation by MRM Architects’ Studio. Photo: Mikel Muruzabal

The jury praised the use of large-format tiles as a quintessential feature of the building envelope. It also commended the use of a standard product, applied in industrial style, to create an outer shell based on the criteria of cleanliness, order and minimum resources.

The new headquarters of the Valencia Construction Sector Employment Foundation is set in rural and semi-industrial surroundings. In keeping with the Valencia region’s physical and cultural backdrop, a decision was taken to use ceramic tiles for the construction and image of the employment centre as they are the region’s flagship manufacturing product, used extensively there.

The winner of the Interior Design category, also receiving a cash prize of 15,000 Euros, was Estudio Vilablanch for ‘Living in a Coderch’, an apartment refurbishment in Barcelona’s emblematic Banco Urquijo building that recaptures the essence of Coderch’s architecture.

‘Living in a Coderch’ by Estudio Vilablanch Photos: Jordi Folch

The judges applauded the project’s rigorous exercise in interior design, in keeping with the spirit of José Antonio Coderch’s architecture, while highlighting the concept of permanence as a common denominator. It also emphasized the skilful choice of materials and meticulous care with which the design project was put into practice.

FINAL DEGREE PROJECT WINNER The award for the Final Degree Project, a category for architecture students with a prize of 5,000 Euros, went to Gonzalo López Elorriaga from Madrid School of Architecture for ‘Castilla La MaRcha’.

The jury highlighted the innovative nature of this project ‘where ceramic tiles play a starring role in a journey from depopulated Spain to an enjoyed Spain’. It involves the creation of a leisure and entertainment resort unlike typical ones, promoting a rural setting in order to revitalize an abandoned space in the town of Peralvillo while also ‘highlighting its value through an efficient unorthodox programme aimed at generating profits and attracting a new population’.

SPECIAL MENTION – ARCHITECTURE In addition to the first prizes, the judges awarded special mentions. For innovation in architecture, Malaga University’s Faculty of Psychology and Speech Therapy by Lips Architects’ Studio (Eduardo Pérez Gómez and Miguel Ángel Sánchez García) stood out for its innovative glossy ceramic skin. The jury were impressed by how the continuous skin was developed for the whole building using round glazed tiles and other smaller ones in the gaps. To facilitate their installation, a mesh-mounted system was used. The layout of the whole building and its cladding overcame possible problems with meeting points, relinquishing the need to cut the tiles or use special tiles.

Above: Malaga University’s Faculty of Psychology and Speech Therapy by Lips Architects’ Studio. Photos: Javier Callejas Sevilla

SPECIAL MENTIONS – INTERIOR DESIGN In the interior design category, ‘JM55’ by BURR caught the judging panel’s eye for its capacity to create vibrant interiors in such a small space, utilising a single central tile feature around which all the other spaces revolve. A special mention also went to ‘Cal Garrofa’ by Julia Tarnawski and Albert Guerra. In this case, special note was made of its radical conceptual philosophy, used to revive a traditional looking home, in addition to the heavy use of colour and ceramic tiles to create a space with strong poetic connotations.

From top to bottomt: ‘JM55’ by BURR and ‘Cal Garrofa’ by Julia Tarnawski and Albert Guerra. Photos: Maru Serrano / Jara Varela

SPECIAL MENTIONS – FINAL DEGREE PROJECT Special mentions were also awarded in the Final Degree Category.

‘A civic centre and temporary accommodation in La Asunción former factory’ by Mariona Dalmau Benavent from La Salle School of Architecture impressed the jury for its environmentally efficient design. The jury highlighted the project’s restrained sobriety. The existing building has been surrounded by a series of box-like volumes, distributed in such a way that Cerda’s original urban grid has been maintained, generating a new model with a permeable layout and facades with a porous visual design.

Also honoured was ‘Hortus Conclusus’ by Teresa Clara Martínez López from Madrid School of Architecture which aims to link Lisbon’s old quarter to San Jorge Castle.

THE JUDGES Presided over by architect Carlos Ferrater (OAB), the jury met at ASCER’s headquarters on November 17 and included Fermín Vázquez (b270), Jaime Sanahuja (Sanahuja & Partners), José Ma Marzo (Tectónica), Alicia Fernández (Alicia Fernández Interiorismo) and Ángel Pitarch (Castellón Architects’ Association)

THE SPONSORS The awards were sponsored by ICEX, Endesa and the Valencia Port Authority.

TILE OF SPAIN Tile of Spain is the voice of the Spanish tile industry, representing more than 125 tile manufacturers. For details of this and previous years’ awards, visit www.tileofspainawards.com

The 20th ASCER Tile of Spain Awards Winners images / information received 280122

Location: Spain

Spanish Architecture

European Architecture

Architecture Awards

Tile of Spain Event, London

Contemporary Interiors

European Copper Architecture Awards

Stirling Prize

Architecture in Spain

Museo de al Memoria de Andalucía, Granada, southern Spain Design: Alberto Campo Baeza Museo de al Memoria de Andalucía

Merida Factory Youth Movement, western Spain Jose Selgas, Lucia Cano, architects Merida Youth Factory

Centro Niemeyer, Avilés Oscar Niemeyer architect Centro Niemeyer

Spanish Architect

Tile of Spain Awards Archive

Call for entries: ASCER’s Tile of Spain Awards 2020 photo © Aldo Amoretti

Winners of the 2019 Tile of Spain Awards

18th Tile of Spain Awards in Architecture Design

Winners of the 2018 Tile of Spain Awards

Open call for 17th Tile of Spain Awards

Open call for the 16th Tile of Spain Awards

Winners of the 2016 Tile of Spain Awards

Tile of Spain Awards 2016

Tile of Spain Awards 2015

Tile of Spain Awards 13th edition Winners

Tile of Spain Awards 2014 Design Contest

Tile of Spain Awards 2013 Design Contest

Tile of Spain Awards

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