#sodium-glucose cotransporter 2 (SGLT2)

[drcare4u]

Study links diabetes drugs to lower risk of dementia and Parkinson's disease

A class of drugs for diabetes may be associated with a lower risk of dementia and Parkinson’s disease, according to a study published in the September 18, 2024, online issue of Neurology®, the medical journal of the American Academy of Neurology. The study looked at sodium-glucose cotransporter-2 (SGLT2) inhibitors, which are also known as gliflozins. They lower blood sugar by causing the kidneys…

[amrutatbrc1]

Sodium Glucose Cotransporter 2 (SGLT2) Inhibitors Market 2024 : Size, Growth Rate, Business Module, Product Scope, Regional Analysis And Expansions 2033

The Sodium Glucose Cotransporter 2 (SGLT2) Inhibitors Global Market Report 2024 by The Business Research Company provides market overview across 60+ geographies in the seven regions - Asia-Pacific, Western Europe, Eastern Europe, North America, South America, the Middle East, and Africa, encompassing 27 major global industries. The report presents a comprehensive analysis over a ten-year historic period (2010-2021) and extends its insights into a ten-year forecast period (2023-2033).

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According to The Business Research Company’s Sodium Glucose Cotransporter 2 (SGLT2) Inhibitors Global Market Report 2024, The sodium glucose cotransporter 2 (SGLT2) inhibitors market size has grown strongly in recent years. It will grow from $9.37 billion in 2023 to $10.17 billion in 2024 at a compound annual growth rate (CAGR) of 8.5%. The growth in the historic period can be attributed to early clinical trial successes, rising regulatory approvals, increasing diabetes diagnosis rates, and the demand for innovative diabetes treatments.

The sodium glucose cotransporter 2 (SGLT2) inhibitors market size is expected to see strong growth in the next few years. It will grow to $14.19 billion in 2028 at a compound annual growth rate (CAGR) of 8.7%. The growth in the forecast period can be attributed to rising diabetes prevalence, increasing obesity rates, growing awareness of diabetes management, and expanding applications in heart and kidney disease treatments. Major trends in the forecast period include the integration of combination therapies, personalized medicine approaches, technological improvement, and traditional drug development.

The increasing prevalence of diabetes is expected to propel the growth of the sodium glucose cotransporter 2 (SGLT2) inhibitor market going forward. Diabetes refers to a group of metabolic disorders characterized by high blood sugar levels resulting from defects in insulin secretion, insulin action, or both. The rise in diabetes cases can be attributed to factors such as urbanization, stress, environmental pollutants, and a lack of access to healthcare services. Sodium glucose cotransporter 2 (SGLT2) inhibitors are used in diabetes treatment to lower blood glucose levels by preventing glucose reabsorption in the kidneys, leading to its excretion in urine. They also offer cardiovascular and renal benefits, making them a valuable option for managing diabetes and its complications. For instance, in July 2021, according to the International Diabetes Federation, a Belgium-based national diabetes association, the total number of people living with diabetes is expected to increase to 643 million by 2030 and 783 million by 2045. Three out of four adults with diabetes reside in low- and middle-income countries. Therefore, the increasing prevalence of diabetes is driving the growth of the sodium glucose cotransporter 2 (SGLT2) inhibitor market.

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The sodium glucose cotransporter 2 (SGLT2) inhibitors market covered in this report is segmented –

1) By Type: Invokana, Jardiance, Farxiga Or Forxiga, Suglat 2) By Route Of Administration: Oral Route, Other Route Of Administration 3) By End User: Hospitals, Homecare Settings, Clinics

Major companies operating in the sodium glucose cotransporter 2 (SGLT2) inhibitor market are focused on developing dual inhibitor therapeutic solutions to improve patient outcomes and manage blood sugar levels. Dual inhibitor therapeutic solutions refer to treatments that simultaneously target two different sodium-glucose cotransporters (SGLT1 and SGLT2) to enhance efficacy in managing conditions such as heart failure and diabetes. For instance, in May 2023, Lexicon Pharmaceuticals Inc., a US-based biopharmaceutical company, received approval from the Food and Drug Administration (FDA) for sotagliflozin, a treatment for heart failure. This first-in-class dual inhibitor of sodium-glucose cotransporters 1 and 2 is a once-daily tablet designed to reduce cardiovascular death, heart failure hospitalizations, and urgent heart failure visits in adults with heart failure, type 2 diabetes, chronic kidney disease, and other cardiovascular risk factors. Its benefits include reduced renal glucose and sodium reabsorption, which leads to preload and afterload reduction and decreased sympathetic activity.

The sodium glucose cotransporter 2 (sglt2) inhibitors market report table of contents includes:

1. Executive Summary

2. Sodium Glucose Cotransporter 2 (SGLT2) Inhibitors Market Characteristics

3. Sodium Glucose Cotransporter 2 (SGLT2) Inhibitors Market Trends And Strategies

4. Sodium Glucose Cotransporter 2 (SGLT2) Inhibitors Market - Macro Economic Scenario

5. Global Sodium Glucose Cotransporter 2 (SGLT2) Inhibitors Market Size and Growth ............

32. Global Sodium Glucose Cotransporter 2 (SGLT2) Inhibitors Market Competitive Benchmarking

33. Global Sodium Glucose Cotransporter 2 (SGLT2) Inhibitors Market Competitive Dashboard

34. Key Mergers And Acquisitions In The Sodium Glucose Cotransporter 2 (SGLT2) Inhibitors Market

35. Sodium Glucose Cotransporter 2 (SGLT2) Inhibitors Market Future Outlook and Potential Analysis

36. Appendix

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[market-insider]

SGLT2 Inhibitors Market Overview: Extensive Evaluation of Market Size, Share, and Growth Opportunities

The global SGLT2 inhibitors market size is anticipated to reach USD 29.43 billion by 2030 and is expected to expand at a CAGR of 7.71% during the forecast period, according to a new report by Grand View Research, Inc. The recommendations and supportive guidelines from major health organizations, such as the American Diabetes Association (ADA), the European Association of for the Study of Diabetes (EASD), the European Society of Cardiology (ESC), and others have endorsed sodium-glucose cotransporter-2 (SGLT2) inhibitors for them beyond glucose control. For instance, in August 2023, the European Society of Cardiology (ESC) has issued a focused update to their heart failure guidelines, integrating findings from nearly a dozen new clinical trials since 2021, such as EMPEROR-Preserved, DELIVER, STRONG-HF, and IRONMAN. Released at the ESC Congress 2023, the updated guidelines introduce new recommendations for the use of SGLT2 inhibitors in treating patients with heart failure with mildly reduced ejection fraction (HFmrEF).

In addition, the growing number of patients needing dialysis over the next few years showcased high demand of medicines such as SGLT2 inhibitors for treatment of CKD patients. In November 2023, the National Institute for Health and Care Excellence (NICE) has issued draft guidance recommending the use of empagliflozin, an SGLT2 inhibitor, for patients with chronic kidney disease (CKD). Empagliflozin has demonstrated efficacy in slowing the progression to kidney failure and reducing the risk of heart attacks and strokes. NICE recommends making this treatment available to patients across all stages of CKD. Such recommendations from drug regulatory agencies are expected to boost demand for drugs during the forecast period.

The elder adults are more prone to type 2 diabetes and heart failure, conditions where drugs have shown substantial benefits. This demographic shift increases the demand for effective treatments such as SGLT2 inhibitors. SGLT2 inhibitors are beneficial in reducing cardiovascular and renal risks, which are particularly prevalent in the elderly. This advantage makes these medications a preferred choice for older patients. According to the World Health Organization (WHO), in 2022, around 1.4 billion people were aged 60 years and over, which was raised from 1 billion in 2020. In addition, WHO estimates that the elderly population is expected to reach 2.1 billion. Thus, rising geriatric population is expected to boost demand for SGLT2 inhibitors worldwide and drive market growth.

Increasing awareness of diabetes and significance of SGLT2 inhibitors in treatment among both patients and healthcare providers contribute to higher prescription rates. For instance, in 2021, the WHO launched initiative “Global Diabetes Compact” to raise awareness and improve patient access to diabetic medicine including SGLT2 inhibitors and insulin. Such initiatives are expected to boost adoption of SGLT2 inhibitors and open new opportunities in the market over the forecast period.

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SGLT2 Inhibitors Market Report Highlights

Jardiance (empagliflozin) segment dominated the market in 2023 and is anticipated to grow significantly over the forecast period. This growth is attributed due to increasing prevalence of diabetes, CKD, and cardiovascular conditions and high drug demand for treatment

Type 2 diabetes segment dominated the market in 2023. This dominance is attributed due to rising incidence of diabetes, increasing geriatric population, and increased prescription rate of drug

Hospital pharmacies segment dominated the market in 2023. This dominance is attributed due to increasing number hospitalization of diabetes, CKD, and heart failure patients for diagnosis and treatment

North America dominated the market owing to factors such as advanced healthcare infrastructure, rising prevalence of target diseases, and favorable regulatory environment

SGLT2 Inhibitors Market Segmentation

Grand View Research has segmented the global SGLT2 inhibitors market on the basis of drug, indication, distribution channel, and region.

Gain deeper insights on the market and receive your free copy with TOC now @: SGLT2 Inhibitors Market Report

[credenceresearchdotblog]

The Chronic Kidney Disease Drugs Market is projected to grow from USD 13,982.37 million in 2023 to USD 20,779.13 million by 2032, reflecting a compound annual growth rate (CAGR) of 4.50%.Chronic Kidney Disease (CKD) is a critical public health issue affecting millions globally. Characterized by a gradual loss of kidney function over time, CKD can lead to severe health complications, including cardiovascular disease, kidney failure, and even death. The increasing prevalence of CKD, fueled by rising incidences of diabetes, hypertension, and an aging population, has led to a growing demand for effective treatments. This demand has, in turn, spurred the growth of the Chronic Kidney Disease Drugs market, making it one of the most dynamic sectors in the global pharmaceutical industry.

Browse the full report at https://www.credenceresearch.com/report/chronic-kidney-disease-ckd-drugs-market

Market Overview

The Chronic Kidney Disease Drugs market has witnessed substantial growth over the past decade, driven by advancements in medical research, a deeper understanding of CKD pathophysiology, and the introduction of novel therapies. As of 2023, the market is estimated to be valued at approximately USD 15 billion, with projections suggesting a compound annual growth rate (CAGR) of around 6-7% through 2030. This growth is underpinned by a combination of factors, including the rising global burden of CKD, increased healthcare spending, and the expanding availability of healthcare services in emerging markets.

Key Drivers of Market Growth

1. Rising Prevalence of CKD: The global incidence of CKD is on the rise, with approximately 10% of the world's population affected. The growing prevalence of risk factors such as diabetes and hypertension, along with an aging population, has significantly contributed to the increased demand for CKD drugs. In particular, the aging population is more susceptible to CKD due to the natural decline in kidney function with age.

2. Advancements in Drug Development: Significant progress has been made in the development of drugs targeting CKD. Traditional treatments, such as angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs), remain the cornerstone of CKD management. However, newer classes of drugs, such as sodium-glucose cotransporter-2 (SGLT2) inhibitors and endothelin receptor antagonists, have shown promise in slowing the progression of CKD and improving patient outcomes. These advancements have broadened the therapeutic options available to patients and healthcare providers, driving market growth.

3. Government Initiatives and Increased Awareness: Governments and healthcare organizations worldwide have recognized CKD as a major public health concern and have launched initiatives to improve awareness, early diagnosis, and treatment. Increased public awareness campaigns and screening programs have led to earlier detection of CKD, allowing for timely intervention and better management of the disease.

4. Emerging Markets: The expansion of healthcare infrastructure in emerging economies, coupled with rising income levels and increased access to healthcare services, has created new opportunities for market growth. Countries in Asia-Pacific, Latin America, and the Middle East are experiencing rapid growth in their CKD drug markets, driven by an increasing prevalence of CKD and a growing demand for effective treatments.

Market Challenges

Despite the positive growth trajectory, the Chronic Kidney Disease Drugs market faces several challenges. One of the primary challenges is the high cost of treatment, particularly for newer, more effective therapies. This can limit access to these treatments, especially in low- and middle-income countries. Additionally, CKD is often asymptomatic in its early stages, leading to late diagnosis and treatment, which can reduce the effectiveness of available therapies.

Another challenge is the complex nature of CKD, which often requires a multifaceted treatment approach. Managing CKD involves not only addressing the underlying causes, such as diabetes and hypertension, but also managing complications such as anemia, bone disease, and cardiovascular issues. This complexity can make it difficult to develop comprehensive treatment plans and may limit the effectiveness of single-drug therapies.

Future Outlook

The future of the Chronic Kidney Disease Drugs market looks promising, with ongoing research and development efforts expected to yield new and more effective treatments. Personalized medicine, which tailors treatment to the individual patient's genetic makeup, lifestyle, and disease characteristics, is likely to play an increasingly important role in CKD management. Additionally, advances in biotechnology and genomics may lead to the development of novel therapies that can slow or even reverse the progression of CKD.

Furthermore, as awareness of CKD continues to grow, and as healthcare systems in emerging markets expand, the demand for CKD drugs is expected to rise. This will likely lead to increased investment in research and development, further driving innovation in the field.

Key Player Analysis

AbbVie, Inc

Allergan Plc.

Amgen Inc.

AstraZeneca Plc.

Hoffman-La Roche Ltd

Fibro Gen

Glaxo Smith Kline Plc.

Johnson & Johnson

Keryx Biopharmaceuticals, Inc

Kissei Pharmaceutical Co. Ltd

Pfizer, Inc.

Sanofi S.A.

Teva Pharmaceutical Co. Ltd

Segments:

Based on Drug Class:

ACE Inhibitors

Angiotensin-II Receptor Blockers

Calcium Channel Blockers

Beta Blockers

Erythropoiesis-stimulating Agents (ESAs)

Diuretics

Others

Based on Route of Administration:

Oral

Subcutaneous

Intravenous

Based on Distribution Channel:

Hospital Pharmacies

Retail Pharmacies

Online Pharmacies

Others

Based on the Geography:

North America

US

Canada

Mexico

Europe

Germany

France

UK

Italy

Spain

Rest of Europe

Asia Pacific

China

Japan

India

South Korea

South-east Asia

Rest of Asia Pacific

Latin America

Brazil

Argentina

Rest of Latin America

Middle East & Africa

GCC Countries

South Africa

Rest of Middle East and Africa

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[heathcareforallworld]

Emerging Trends in the SGLT2 Inhibitors Market: A 2032 Outlook

Introduction

The Sodium-Glucose Cotransporter-2 (SGLT2) inhibitors market is witnessing significant growth due to the rising prevalence of diabetes worldwide and the increasing adoption of these drugs in the management of type 2 diabetes. This class of medications works by preventing the kidneys from reabsorbing glucose, thereby lowering blood sugar levels. As the global healthcare industry focuses on innovative treatments and improved patient outcomes, the SGLT2 inhibitors market is expected to expand substantially over the forecast period from 2024 to 2032.

Market Size and Share

The SGLT2 inhibitors market is projected to grow at a robust rate, driven by factors such as the growing diabetic population, increased healthcare spending, and advancements in pharmaceutical research. Sglt2 Inhibitors Market Size was estimated at 9.36 (USD Billion) in 2023. The Sglt2 Inhibitors Market Industry is expected to grow from 10.41(USD Billion) in 2024 to 24.5 (USD Billion) by 2032. The Sglt2 Inhibitors Market CAGR (growth rate) is expected to be around 11.29% during the forecast period (2024 - 2032).

North America holds the largest market share due to the high prevalence of diabetes and well-established healthcare infrastructure. The United States, in particular, is a significant contributor to the market's revenue. Europe follows closely, with countries like Germany, France, and the UK being major markets. The Asia-Pacific region is expected to witness the highest growth rate during the forecast period, driven by increasing healthcare awareness, rising disposable incomes, and the growing burden of diabetes in countries such as China and India.

Key Drivers of Market Growth

Rising Prevalence of Diabetes: The global incidence of diabetes, particularly type 2 diabetes, is on the rise. This surge is attributed to factors such as sedentary lifestyles, unhealthy diets, and an aging population. As diabetes becomes more prevalent, the demand for effective treatment options, including SGLT2 inhibitors, increases.

Advancements in Pharmaceutical Research: Continuous research and development in the pharmaceutical industry have led to the introduction of advanced SGLT2 inhibitors with improved efficacy and safety profiles. Innovations such as combination therapies (SGLT2 inhibitors combined with other antidiabetic agents) are also gaining traction.

Increased Healthcare Spending: Governments and private sectors across the globe are investing heavily in healthcare infrastructure and services. This investment is facilitating better access to medications and advanced treatments, thereby boosting the adoption of SGLT2 inhibitors.

Regulatory Approvals and Favorable Guidelines: Regulatory bodies such as the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) have approved several SGLT2 inhibitors, ensuring their safety and efficacy. Additionally, clinical guidelines from organizations like the American Diabetes Association (ADA) recommend SGLT2 inhibitors for managing type 2 diabetes, further driving their market growth.

Industry Trends

Expansion of Indications: Initially approved for the treatment of type 2 diabetes, SGLT2 inhibitors are now being investigated for other indications, including heart failure and chronic kidney disease. Positive clinical trial results in these areas are likely to expand the market further.

Combination Therapies: The trend towards combination therapies is gaining momentum, as combining SGLT2 inhibitors with other antidiabetic drugs (such as GLP-1 receptor agonists) offers enhanced glycemic control and cardiovascular benefits.

Focus on Cardiovascular Benefits: SGLT2 inhibitors have demonstrated significant cardiovascular benefits, including reduced risk of heart failure and cardiovascular death. This has led to their increased use in patients with cardiovascular diseases, driving market growth.

Patient-Centric Approaches: Pharmaceutical companies are focusing on patient-centric approaches, such as developing user-friendly drug delivery systems and conducting awareness campaigns to educate patients about the benefits of SGLT2 inhibitors.

Challenges and Restraints

Side Effects and Safety Concerns: Despite their benefits, SGLT2 inhibitors are associated with certain side effects, such as urinary tract infections, genital infections, and ketoacidosis. These safety concerns may limit their widespread adoption.

High Costs: The cost of SGLT2 inhibitors is relatively high, which may pose a barrier to their adoption, especially in low-income countries with limited healthcare budgets.

Competition from Other Antidiabetic Agents: The market faces competition from other classes of antidiabetic agents, such as GLP-1 receptor agonists and DPP-4 inhibitors. The availability of multiple treatment options can influence prescribing patterns and impact market growth.

Regional Analysis

North America: Dominates the market with the highest revenue share due to the high prevalence of diabetes and a strong healthcare system. The U.S. is the major contributor to this region's market growth.

Europe: Holds a significant market share, with Germany, France, and the UK being key markets. The presence of leading pharmaceutical companies and advanced healthcare infrastructure supports market growth.

Asia-Pacific: Expected to witness the highest growth rate due to increasing healthcare awareness, rising disposable incomes, and the growing diabetic population in countries like China and India.

Latin America and Middle East & Africa: These regions are also expected to show steady growth due to improving healthcare infrastructure and increasing awareness about diabetes management.

Future Outlook and Forecast

The future of the SGLT2 inhibitors market looks promising, with significant growth anticipated over the forecast period. The market is expected to benefit from continuous advancements in pharmaceutical research, expansion of therapeutic indications, and increasing adoption of combination therapies.

Conclusion

The SGLT2 inhibitors market is assured of substantial growth, driven by the rising prevalence of diabetes, advancements in pharmaceutical research, and increased healthcare spending. While challenges such as safety concerns and high costs persist, the market is expected to expand significantly, offering new opportunities for pharmaceutical companies and improved treatment options for patients. As the market evolves, continued innovation and patient-centric approaches will be crucial in driving its success through 2032.

[drrahulmathurgeneralphysician]

Balancing Act: Medication Management in Diabetes Care

Introduction: Understanding the Importance of Medication Management in Diabetes

Diabetes, a chronic condition characterized by high blood sugar levels, requires careful management to prevent complications and maintain overall health. While lifestyle modifications such as diet and exercise play a crucial role, medication management is often necessary to achieve optimal blood sugar control. In Jaipur, individuals grappling with diabetes rely on experts like Dr. Rahul Mathur at Swasthya Clinics to navigate the complexities of medication management and ensure a balanced approach to their care.

Causes of Medication Management in Diabetes

The need for medication management in diabetes arises from various factors. Individuals with diabetes may have difficulty maintaining stable blood sugar levels despite lifestyle modifications due to factors such as insulin resistance or insufficient insulin production. Additionally, lifestyle factors, genetics, and other medical conditions can influence diabetes management, necessitating the use of medications to achieve target blood sugar levels.

Prevention: The Role of Medication Management in Diabetes Control

Effective medication management plays a pivotal role in preventing diabetes-related complications such as cardiovascular disease, kidney damage, nerve damage, and vision problems. By helping individuals achieve and maintain target blood sugar levels, medications reduce the risk of long-term complications and improve overall quality of life. Furthermore, proper medication management can help prevent acute complications such as hyperglycemia (high blood sugar) and hypoglycemia (low blood sugar), which can have serious consequences if left untreated.

Dr. Mathur's Prescription for Medication Management

As a diabetes doctor in Jaipur, Dr. Rahul Mathur understands the importance of individualized treatment plans tailored to each patient's unique needs. Dr. Rahul Mathur typically begins by conducting a comprehensive evaluation, including a thorough medical history, physical examination, and laboratory tests to assess blood sugar levels and identify any underlying health issues. Based on this assessment, he devises a personalized medication regimen that may include:

Oral Medications: For individuals with type 2 diabetes, oral medications such as metformin, sulfonylureas, or dipeptidyl peptidase-4 (DPP-4) inhibitors may be prescribed to help lower blood sugar levels by improving insulin sensitivity or stimulating insulin production.

Insulin Therapy: Some individuals with type 1 diabetes or advanced type 2 diabetes may require insulin therapy to control their blood sugar levels effectively. Dr. Mathur may prescribe different types of insulin, such as rapid-acting, short-acting, intermediate-acting, or long-acting insulin, depending on the patient's needs.

Injectable Medications: In addition to insulin, Dr. Mathur may prescribe injectable medications such as glucagon-like peptide-1 (GLP-1) receptor agonists or sodium-glucose cotransporter-2 (SGLT2) inhibitors to help lower blood sugar levels and reduce the risk of cardiovascular events in certain individuals with diabetes.

Combination Therapy: In some cases, Dr. Mathur may recommend combination therapy, which involves using multiple medications with different mechanisms of action to achieve better blood sugar control. This approach may include combining oral medications with insulin or other injectable medications to optimize diabetes management.

Conclusion: Achieving Balance Through Medication Management

In conclusion, medication management plays a crucial role in diabetes care, helping individuals achieve and maintain optimal blood sugar control to prevent complications and improve overall health outcomes. In Jaipur, individuals with diabetes can rely on experts like Dr. Rahul Mathur at Swasthya Clinics to guide them through the complexities of medication management and empower them to lead healthier lives. By balancing lifestyle modifications with appropriate medications, individuals with diabetes can effectively manage their condition and reduce the risk of long-term complications.

[ivy-hospital]

What is the latest treatment for chronic kidney disease?

Chronic kidney disease (CKD) affects millions worldwide, posing significant health challenges. As medical science advances, so do treatment options for this condition. Among the latest innovations in CKD management, several promising therapies have emerged, offering hope for improved outcomes and enhanced quality of life.

One notable advancement in CKD treatment is the use of novel medications targeting specific pathways involved in the progression of the disease. These medications, such as angiotensin receptor blockers (ARBs), angiotensin-converting enzyme (ACE) inhibitors, and sodium-glucose cotransporter-2 (SGLT2) inhibitors, have shown efficacy in slowing the decline of kidney function and reducing the risk of complications associated with CKD, such as cardiovascular disease.

Furthermore, advancements in renal replacement therapy, including hemodialysis, peritoneal dialysis, and kidney transplantation, have revolutionized the management of end-stage renal disease (ESRD), the most severe stage of CKD. Technological innovations in dialysis machines and techniques have led to improved efficiency, safety, and patient comfort during dialysis sessions. Additionally, advances in organ preservation, immunosuppressive therapies, and surgical techniques have enhanced the success rates of kidney transplantation, offering a viable long-term solution for eligible CKD patients.

Another promising area of research in CKD treatment involves regenerative medicine and tissue engineering. Scientists are exploring the use of stem cells, growth factors, and biomaterials to repair damaged kidney tissue and promote regeneration. While still in the experimental stage, these therapies hold immense potential for reversing kidney damage and restoring function in patients with CKD.

Moreover, personalized medicine approaches are gaining traction in CKD management, allowing healthcare providers to tailor treatment strategies based on individual patient characteristics, including genetic predisposition, comorbidities, and lifestyle factors. By optimizing therapy regimens to suit each patient's unique needs, personalized medicine holds promise for maximizing treatment efficacy and minimizing adverse effects.

In addition to pharmacological and procedural interventions, lifestyle modifications play a crucial role in managing CKD and slowing disease progression. Dietary interventions, such as reducing sodium intake, limiting phosphorus and potassium consumption, and adhering to a balanced diet rich in fruits, vegetables, and lean proteins, can help mitigate complications and improve overall health outcomes for CKD patients.

In conclusion, the latest advancements in CKD treatment encompass a multidisciplinary approach, combining pharmacotherapy, renal replacement therapy, regenerative medicine, personalized medicine, and lifestyle modifications. By harnessing these innovative therapies, healthcare providers can better manage CKD, enhance patient outcomes, and ultimately improve the quality of life for individuals affected by this chronic condition.

Ivy Hospital stands at the forefront of chronic kidney disease (CKD) treatment across Mohali, Hoshiarpur, Khanna, Nawanshahr, and Amritsar. Renowned for its expertise in nephrology, Ivy Hospital offers comprehensive care tailored to each patient's unique needs. With state-of-the-art facilities and a multidisciplinary team of specialists, Ivy Hospital provides advanced diagnostics, innovative treatments, and personalized management plans to effectively address CKD at all stages. From medication management to renal replacement therapy options like dialysis and transplantation, Ivy Hospital ensures the highest standards of care, prioritizing patient well-being and long-term health outcomes. Trust in Ivy Hospital's commitment to excellence in CKD treatment, delivering compassionate care and fostering hope for individuals and families affected by this challenging condition.

[daisyveraa]

What is the role of dapagliflozin for treatment of heart failure?

Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor that has historically been used as an anti-diabetic agent in adults with type 2 diabetes mellitus (T2DM) to improve glycemic control.1,2 After expedited drug review via fast track and priority review designations, the Food and Drug Administration (FDA) approved dapagliflozin on May 5, 2020 to reduce the risk of cardiovascular (CV) death and hospitalization due to heart failure (HF) in adults with New York Heart Association (NYHA) class II, III, or IV symptoms and HF with reduced ejection fraction (HFrEF).3 This FDA approval makes dapagliflozin the first SGLT2 inhibitor to be approved for this indication or for use in patients without T2DM.

[novaglobalhealthcare]

What Are My Options for Type 2 Diabetes Medications?

There are different types, or classes, of medications that work in different ways to lower blood glucose (also known as blood sugar) levels. Some options are taken by mouth and others are injected. Some of the commonly used classes of non-insulin medications include:

Metformin

Dipeptidyl peptidase 4 (DPP-4) inhibitors

Glucagon-like peptide 1 (GLP-1) and dual GLP-1/gastric inhibitory peptide (GIP) receptor agonists

Sodium-glucose cotransporter 2 (SGLT2) inhibitors

Sulfonylureas

Thiazolidinediones (TZDs)

Metformin

Metformin (Glucophage) is classified as a biguanide medication and is the only available medication in this class. Metformin lowers blood glucose levels primarily by decreasing the amount of glucose produced by the liver. Metformin also helps lower blood glucose levels by making muscle tissue more sensitive to insulin so blood glucose can be used for energy.

It is usually taken two times a day. A side effect of metformin may be diarrhea, but this is improved when the drug is taken with food.

DPP-4 Inhibitors

DPP-4 inhibitors help improve A1C (a measure of average blood glucose levels over two to three months) without causing hypoglycemia (low blood glucose). They work by preventing the breakdown of naturally occurring hormones in the body, GLP-1 and GIP. These hormones reduce blood glucose levels in the body, but they are broken down very quickly so it does not work well when injected as a drug itself.

By interfering in the process that breaks down GLP-1 and GIP, DPP-4 inhibitors allow these hormones to remain active in the body longer, lowering blood glucose levels only when they are elevated. DPP-4 inhibitors do not cause weight gain and are usually very well tolerated.

There are four DPP-4 inhibitors currently on the market in the U.S.:

Alogliptin (Nesina)

Linagliptin (Tradjenta)

Saxagliptin (Onglyza)

Sitagliptin (Januvia)

GLP-1 and Dual GLP-1/GIP Receptor Agonists

As noted in the description for DPP-4 inhibitors, GLP-1 and GIP are natural hormones in the body that help maintain glucose levels. Use of GLP-1 and dual GLP-1/GIP receptor agonists is another strategy to help use these hormones to improve blood glucose management in people with type 2 diabetes.

These medications have similar effects to the GLP-1 and GIP produced in the body but are resistant to being broken down by the DPP-4 enzyme. These medications can result in large benefits on lowering blood glucose and body weight. Some agents in this class have also been shown to prevent heart disease. Most of these medications are injected, with the exception of one that is taken by mouth once daily, called semaglutide (Rybelsus).

Injectable GLP-1 receptor agonists currently on the market include:

Dulaglutide (Trulicity)

Exenatide (Byetta)

Exenatide extended-release (Bydureon)

Liraglutide (Victoza)

Lixisenatide (Adlyxin)

Injectable semaglutide (Ozempic)

One dual GLP-1/GIP receptor agonist is currently on the market called tirzepatide (Mounjaro). How often you need to inject these medications varies from twice daily to once weekly, depending on the medication. The most common side effect with these medications is nausea and vomiting, which is more common when starting or increasing the dose.

SGLT2 Inhibitors

Glucose in the bloodstream passes through the kidneys where it can either be excreted in the urine or reabsorbed back into the blood. Sodium-glucose cotransporter 2 (SGLT2) works in the kidney to reabsorb glucose. A new class of medication, SGLT2 inhibitors, block this action, causing excess glucose to be eliminated in the urine.

By increasing the amount of glucose excreted in the urine, people can see improved blood glucose, some weight loss, and small decreases in blood pressure. Bexagliflozin (Brenzavvy), canagliflozin (Invokana), dapagliflozin (Farxiga), and empagliflozin (Jardiance) are SGLT2 inhibitors that have been approved by the Food and Drug Administration (FDA) to treat type 2 diabetes. SGLT2 inhibitors are also known to help improve outcomes in people with heart disease, kidney disease, and heart failure.

For this reason, these medications are often used in people with type 2 diabetes who also have heart or kidney problems. Because they increase glucose levels in the urine, the most common side effects include genital yeast infections.

Sulfonylureas

Sulfonylureas have been in use since the 1950s and they stimulate beta cells in the pancreas to release more insulin. There are three main sulfonylurea drugs used today, glimepiride (Amaryl), glipizide (Glucotrol and Glucotrol XL), and glyburide (Micronase, Glynase, and Diabeta). These drugs are generally taken one to two times a day before meals.

All sulfonylurea drugs have similar effects on blood glucose levels, but they differ in side effects, how often they are taken, and interactions with other drugs. The most common side effects with sulfonylureas are low blood glucose and weight gain.

TZDs

Rosiglitazone (Avandia) and pioglitazone (Actos) are in a group of drugs called thiazolidinediones. These drugs help insulin work better in the muscle and fat and reduce glucose production in the liver.

A benefit of TZDs is that they lower blood glucose without having a high risk for causing low blood glucose. Both drugs in this class can increase the risk for heart failure in some individuals and can also cause fluid retention (edema) in the legs and feet.

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Best Guide to jardiance 25 mg buy online Tablet in Diabetes Management

Jardiance (empagliflozin) is a medication used to treat type 2 diabetes. It is an oral medication available in tablet form. Empagliflozin belongs to a class of drugs known as sodium-glucose cotransporter 2 (SGLT2) inhibitors.

The usual starting dose of Jardiance is a 25 mg tablet once daily. However, the dosage may be adjusted based on individual response and tolerability. The maximum recommended daily dose is 25 mg.

Please note that medication information might change over time, so it is essential to consult a healthcare professional or check the most recent prescribing information for Jardiance to get accurate and up-to-date dosage instructions and any other relevant details. If you have any specific questions or concerns about this medication, it's best to consult with a healthcare provider.

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Dapagliflozin Exporters Shobhalifesciences is a renowned Dapagliflozin Manufacturers In India, Exporters to help you with your requirements and maintain quality products. We are established in 2021, we follow strignent standards, WHO-GMP, ISO, and ICE certified company.

we are committed to developing quality products. Shobha Life Sciences was incorporated in 2021 to serve as a preclinical contract research organisation providing facilities for various experiments such as stability studies, pharmacokinetic, toxicological, and efficacy studies. Since then, we have expanded our scope and have been offering world-class pharmaceutical drugs and intermediates.

Dapagliflozin Applications Dapagliflozin is a medication used to treat type 2 diabetes. It belongs to a class of drugs called sodium-glucose cotransporter 2 (SGLT2) inhibitors. It works by blocking the reabsorption of glucose by the kidneys, causing more glucose to be excreted in the urine. This leads to a decrease in blood glucose levels. It is also used as an adjunct to diet and exercise to improve glycaemic control in adults with type 2 diabetes. It can be used alone or in combination with other diabetes medications such as metformin or sulfonylurea. Additionally, Dapagliflozin has been seen to have a positive effect on reducing the risk of cardiovascular death in diabetic patients. Our Work Flow: We have set our sights on becoming the most recognised names in the field. We are currently working through a series of comprehensive action plans, associations with medical institutions, and aligning our R&D initiatives with the organisational goal. Our leadership team of 4 have a combined experience of almost 60 years and is the guiding force of the team. To meet the ever-increasing demand for our life-saving drugs, we have established a massive 6000 sq. ft warehouse with ample storage space for immediate and future requirements. We run three shifts with 2MT production in every shift. Our team of exceptionally skilled and driven professionals ensure every process and regulation is being adhered to. We are the largest dapagliflozin manufacturers in India not merely because of our number but for our unwavering commitment to quality and our client's present and future needs.

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Weight Loss Medications and Type 2 Diabetes: An Effective Approach

For individuals struggling with weight loss while managing type 2 diabetes, weight loss medications can be a valuable tool. These medications, when used in conjunction with a healthy eating plan and regular physical activity, can help individuals achieve successful weight loss and improve diabetes management. This article explores the use of weight loss medications and their effectiveness in the context of type 2 diabetes.

Weight loss medications work by suppressing appetite, reducing absorption of nutrients, or increasing the feeling of fullness. They can be prescribed by healthcare professionals for individuals who have not been able to achieve weight loss through lifestyle modifications alone. However,it's important to note that weight loss medications are not a magic solution and should be used under the guidance of a healthcare provider.

There are several weight loss medications approved by regulatory authorities for use in individuals with type 2 diabetes. Some of these medications include glucagon-like peptide-1 (GLP-1) receptor agonists, sodium-glucose cotransporter-2 (SGLT2) inhibitors, and combination medications.

GLP-1 receptor agonists work by mimicking the effects of the hormone GLP-1, which increases insulin secretion, slows down stomach emptying, and reduces appetite. These medications not only aid in weight loss but also help improve blood sugar control. Some common GLP-1 receptor agonists include liraglutide and semaglutide.

SGLT2 inhibitors, on the other hand, work by blocking the reabsorption of glucose in the kidneys, leading to increased glucose excretion in the urine. This mechanism helps lower blood sugar levels and promotes weight loss. Empagliflozin and dapagliflozin are examples of SGLT2 inhibitors used in the management of type 2 diabetes.

Combination medications, such as fixed-dose combinations of GLP-1 receptor agonists and basal insulin, provide the benefits of both medications in a single injection. These combinations can help individuals achieve weight loss while also addressing insulin deficiency.

It is important to note that weight loss medications should be used in conjunction with a healthy eating plan and regular physical activity. These medications are most effective when combined with lifestyle modifications. Additionally, weight loss medications may have side effects and contraindications, so it is crucial to consult with a healthcare provider before starting any medication.

Successful weight loss with the help of medications requires ongoing monitoring and adjustments. Regular follow-ups with your healthcare provider are essential to evaluate the effectiveness of the medication, manage any side effects, and make necessary changes to your treatment plan.

In conclusion, weight loss medications can be an effective approach for individuals with type 2 diabetes who are struggling to lose weight through lifestyle modifications alone. These medications, when used under the guidance of a healthcare provider, can aid in weight loss and improve blood sugar control. However, it is important to remember that weight loss medications should be used in conjunction with a healthy eating plan, regular physical activity, and ongoing medical supervision.

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【健康醫療網／記者王冠廷報導】68歲男性出現漸進性的雙下肢水腫至臺中榮總腎臟內科求診，同時併發呼吸困難、尿量減少、體重增加，診斷為急性腎損傷引發的全身水腫與肺部積水。同時被發現有大量的尿蛋白以及心臟衰竭，團隊使用心臟衰竭的用藥以及利尿劑，病患體重減少了14公斤症狀大幅好轉並順利出院。 末期腎病盛行高　糖尿病患者增加 回顧過去病史，病患的糖尿病已經診斷四年，並且有慢性腎臟病，雖然血糖控制得當，但仍然出現急性腎損傷與心臟衰竭的併發症。經過鍾牧圻醫師詳細說明後，給予病患開始使用第2 型鈉-葡萄糖共同轉運蛋白(SGLT2, Sodium glucose cotransporter…

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Dapagliflozin Manufacturers In India

Shobhalifesciences is a renowned Dapagliflozin Manufacturers In India, Exporters help you with your conditions and maintain quality products. We're established in 2021, and we follow stringent norms, WHO- GMP, ISO, and ICE certified company. 

we are committed to developing quality products. Shobha Life Sciences was incorporated in 2021 to serve as a preclinical contract exploration organization furnishing installations for colorful trials similar to stability studies, pharmacokinetic, toxicological, and efficacity studies. Since also, we've expanded our compass and have been offering world-class medicinal medicines and interceders. 

Dapagliflozin Applications 

Dapagliflozin is a drug used to treat type 2 diabetes. It belongs to a class of medicines called sodium-glucose cotransporter 2( SGLT2) impediments. 

It works by blocking the reabsorption of glucose by the feathers, causing further glucose to be excreted in the urine. 

This leads to a drop in blood glucose situations. It's also used as an adjunct to diet and exercise to ameliorate glycaemic control in grown-ups with type 2 diabetes. 

It can be used alone or in combination with other diabetes specifics similar to metformin or sulfonylurea. also, Dapagliflozin has been seen to have a positive effect on reducing the threat of cardiovascular death in diabetic cases. 

 Our WorkFlow We've set our sights on getting the most recognized names in the field. We're presently working through a series of comprehensive action plans, associations with medical institutions, and aligning our R&D enterprise with the organizational thing. Our leadership platoon of 4 has concerted experience nearly 60 times and is the guiding force of the platoon. To meet the ever-adding demand for our life-saving medicines, we've established a massive 6000sq. ft storehouse with ample storehouse space for immediate and unborn conditions. We run three shifts with 2MT products in every shift. Our platoon of exceptionally professed and impulsive professionals insure every process and regulation is being stuck to. We're the largest dapagliflozin manufacturers in India not simply because of our number but for our unvarying commitment to quality and our customer's present and unborn requirements. 

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"Sodium glucose cotransporter 2" বা "SGLT2" হল এক ধরনের প্রোটিন যা কিডনির কোষগুলিতে পাওয়া যায়। এটি কিডনিতে গ্লুকোজের পুনর্শোষণ নিয়ন্ত্রণ করে শরীরে গ্লুকোজের মাত্রা নিয়ন্ত্রণে গুরুত্বপূর্ণ ভূমিকা পালন করে। সাধারণত, কিডনি রক্ত থেকে গ্লুকোজ ফিল্টার করে এবং শরীরে গ্লুকোজের ভারসাম্য বজায় রাখার জন্য রক্ত প্রবাহে তা ফেরত পাঠায়। সুস্থ মানবদেহের জন্য এই প্রক্রিয়া স্বাভাবিক এবং অতি প্রয়োজনীয়। কিন্তু ডায়াবেটিস রোগীদের মধ্যে এই প্রক্রিয়াটি ব্যাহত হয়, যার ফলে রক্তে এবং প্রস্রাবে গ্লুকোজের মাত্রা নিয়ন্ত্রণে থাকেনা। এবং আমরা জানি যে ডায়াবেটিস রোগীদের রক্তে গ্লুকোজের পরিমাণ কমানোর প্রয়োজন পরে। ডায়াবেটিস রোগীদের রক্তে গ্লুকোজের পরিমাণ কমাতে "SGLT2 Inhibitor" জাতীয় ঔষধ ব্যবহার করা হয়, এই "SGLT2 Inhibitor" টাইপ 2 ডায়াবেটিসের চিকিৎসায় ব্যবহৃত হয়। যা "SGLT2" এর স্বাভাবিক কাজকে বন্ধ করে দেয়, যার ফলে কিডনি গ্লুকোজ ফিল্টারের পর তা পুনরায় রক্তে প্রেরণ করতে পারেনা এবং প্রস্রাবে সে গ্লুকোজ নির্গত হয়ে যায়। এভাবে এটি রক্তে গ্লুকোজের মাত্রা কমাতে সাহায্য করে এবং ডায়াবেটিস নিয়ন্ত্রণে রাখে। এই "SGLT2 Inhibitors" কখনও কখনও হার্ট ফেইলিওর এবং দীর্ঘস্থায়ী কিডনি রোগের চিকিত্সার জন্য ব্যবহৃত হয়। কিন্তু অতি মাত্রায় জ্বর বা বমি হলে এটা ব্যবহারে সাবধানতা দরকার, নিতে হবে ডাক্তার বা ফার্মাসিস্টের পরামর্শ। (চিকিৎসা বিজ্ঞানের কঠিন আলোচনা গুলো সহজবোধ্য তথ্য হিসেবে প্রকাশ করার আগ্রহ থেকেই মাঝে মাঝে এমন পোস্ট করে থাকি, অনুবাদিত তথ্যে ভুল থাকলে জানানোর অনুরোধ রইলো) #healthinformation #medication #pharmacology #drugsafety #kidneyhealth #diabetes #SGLT2 #SGLT2inhibitor #pharmacist https://www.instagram.com/p/Cp-TY7bPKQm/?igshid=NGJjMDIxMWI=