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vjinstruments · 1 year

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The Evolution of Transdermal Patch Machines: How Technology is Improving Drug Delivery

A transdermal patch is a small adhesive patch that delivers the drug through the skin. A transdermal patch is a unique drug delivery system that is used for medications that need to be delivered slowly and continuously over an extended period, like pain medications or nicotine replacement therapy (NRT). Transdermal patches are easy to use and can be worn discreetly. A patient who needs to receive medication continuously over a long period will benefit from a transdermal patch. Transdermal patches can bypass the digestive system and liver, which reduces the risk of side effects and increases the bioavailability of the medication. They also offer more convenient administration, which improves patient adherence to treatment plans.

A transdermal patch machine is a specialized device used to manufacture transdermal patches. This machine is designed to manufacture transdermal patches with precisely controlled amounts and rates of drug delivery.

How transdermal patch machines have evolved over the years

The transdermal patch machine has undergone significant changes and advancements over the years, due to an increased demand for transdermal drug delivery and the need for more efficient and effective production processes. These are a few ways in which transdermal patch machines have evolved.

Increased Automation

Transdermal patch machines now have increased automation that allows faster production times, increased efficiency, and greater consistency in patch quality.

Improved Precision

The modern transdermal patch machine offers greater precision and accuracy. Improved precision and accuracy allow more consistent dosages and improved drug delivery.

Innovative Technologies

Transdermal patch machines now incorporate innovative technologies like microfluidics, electrospraying, and nanotechnology, which allow for greater control over the drug delivery process and more targeted drug delivery.

Better Adhesive Systems

Advances in adhesive systems allow transdermal patches manufactured by modern transdermal patch machines to adhere better to the skin, increase comfort, and reduce irritation or allergic reactions.

Customization

The modern transdermal patch machine is capable of producing patches in a wider range of shapes, sizes, and dosages, allowing for greater customization of drug delivery systems.

Digital Controls

Modern transdermal patch machines include digital controls that allow for greater control over production parameters such as temperature, speed, and pressure, resulting in improved patch quality.

Improved Safety Features

Almost every modern transdermal patch machine now incorporates safety features such as emergency stop buttons and safety guards, making them safer to operate.

Transdermal patch machines have evolved to be more efficient, and precise, and have versatile production processes. As technology continues to advance transdermal patch machines will continue to evolve, allowing for even more targeted, effective, and efficient drug delivery.

How transdermal patch machines have improved drug delivery

Transdermal patch machines are designed to improve drug delivery by ensuring that the active pharmaceutical ingredient (API) is delivered through the skin and into the bloodstream at a controlled rate over a predetermined period. This helps to improve the efficacy of the drug and reduces the potential for adverse side effects, as the patches can bypass the digestive system and liver and increase the bioavailability of the medication.

The transdermal patch machine manufactures patches that are typically comprised of several layers. These include a backing layer, an adhesive layer, and a drug-containing layer. The adhesive layer allows the patch to adhere to the skin, the drug-containing layer contains the active pharmaceutical ingredient (API) in a form that can be absorbed through the skin, and the backing layer protects the patch from damage and contamination.

The transdermal patch machine ensures that the layers are assembled in the correct order and with the correct thickness. They also ensure that the drug is distributed evenly throughout the patch. By controlling the thickness and composition of the patch, the transdermal patch machine can control the rate at which the drug is released and absorbed through the skin. This allows for a controlled and sustained delivery of the drug, which can help to improve its efficacy and reduce the risk of adverse side effects.

The most common transdermal patch machines are the tabletop transdermal patch machine and pilot scale transdermal patch machine. These machines are supplied by VJ Instruments, the best Scientific and Preclinical instrument vendor globally. The tabletop transdermal patch machine is designed to efficiently produce transdermal patches in large quantities, with consistent quality and accuracy. On the other hand, the pilot-scale transdermal patch machine is designed to create small batches of transdermal patches for testing and research purposes, before full-scale manufacturing.

VJ Instruments are the best vendors for behavior instruments, R&D equipment, transdermal machines, scientific pieces of equipment, Preclinical instruments, and more. VJ Instruments supplies a range of world-class products that comply with quality standards and focus on “ease of use” at competitive prices. They continuously carry out the actual manufacturing processes, software development, and R&D which helps them understand prevailing market trends, technological advancements, and customer requirements.

VJ Instruments also supplies pharmaceutical instruments like the pelletizing machine and the fluid bed processor. The VJ Instruments pelletizing machine is a type of equipment used in the pharmaceutical industry to convert powder or granular materials into small, cylindrical pellets. These pellets produced by the pelletizing machine are used in pharmaceutical tablets & capsules. The VJ Instruments fluid bed processor is used in pharmaceuticals for granulation, coating on granules, pelletization, and drying of pharmaceutical products. The fluid bed processor enhances product quality and is used to make sustainable release coating and enteric coating drugs. The new fluid bed processor technology improves product quality, reduces processing time, and reduces the cost of the manufacturing process. The specifications and information on VJ Instruments' transdermal patch machine, fluid bed processor, pelletizing machine, and several more Scientific and Preclinical products can be found on the vjinstruments.com website.

#transdermalpatchmachine #fbdfluidbeddryer #pelletizing machine

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fusion360 · 3 years

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Kailo Uses No Drugs

The future of pain relief is here. Kailo pain patches use nanotechnology that interacts with the body's electrical system. Kailo has allowed over 90% of customers to find pain relief without the use of drugs. Lower back pain is a growing issue among otherwise healthy individuals.

Don't let lower back pain take over your life. Your lumbar spine helps support the weight of your upper body while providing the mobility you need for everyday tasks. The Kailo pain patch is potentially used to help recover faster and improve flexibility. It may also help you regain a natural range of motion.

The pain relief patch is non-transdermal, which means no active delivery of ingredients across your skin membrane. They work like antennas that provide signal transmission, bio-identification, and energy storage. It allows the body to kick into overdrive by helping the brain communicate with problem areas. The billions of tiny capacitors are designed to react to the electrical charges inside your body.

Lower back pain can be a constant struggle to improve. There's the argument of bed rest vs. remaining active. When wearing a Kailo pain patch, it may be easier to keep on the move. Combined with good lifting and bending techniques, you may begin to start feeling better with the use of a pain relief patch. Pain in the lower back is usually caused by injury to the muscles, ligaments, discs, and joints. From the complexity of the nerves to all these structures, it's sometimes hard for the brain to sense what is causing the pain. Kailo patches may help in providing a more targeted response.

Kailo pain-relieving patches are the only topical patch on the market to offer a complete solution. They're FDA registered, drug-free, peer-reviewed, available directly from the manufacturer, and have thousands of positive customer testimonials. They're also a much more economical solution, with the potential to last years before needing replacement.

#Kailo #pain patch #painpatch

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marksmithimarc · 4 years

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Hormone Replacement Therapy Market Share, Growth, Challenges, & Global Forecast 2021 to 2026

According to the recent report by IMARC Group, titled “Hormone Replacement Therapy Market: Global Industry Trends, Share, Size, Growth, Opportunity and Forecast 2021-2026,” the global hormone replacement therapy market size reached US$ 4.5 Billion in 2019. Hormone replacement therapy (HRT) refers to a type of treatment wherein low levels of hormones in the body are replenished. It helps in balancing the estrogen or progesterone levels in women nearing menopause. Apart from this, it is suitable for patients with a deficiency of growth hormone and elderly patients suffering from hypogonadism. As HRT is considered an efficacious treatment, patients now prefer it over herbal medicines or chemical drugs. This therapy is available in different forms, including gels, implants, skin and mouth patches, and injections. However, HRT may cause some side effects such as nausea, bloating, indigestion, headaches, and cramps.

Get a sample copy of this Report: https://www.imarcgroup.com/hormone-replacement-therapy-market/requestsample

Global Hormone Replacement Therapy Market Trends:

One of the major growth-inducing factors of the market is the rising cases of hormonal imbalance disorders in the neonatal and geriatric populations around the globe. Moreover, the increasing cases of hypogonadism due to poor health and obesity among the geriatric population have created a high demand for HRT in developed regions like North America. Besides this, menopausal women are the leading population base propelling the market growth. A number of women are gaining awareness regarding HRT and its effective results, which has effectively increased its demand in most countries. Furthermore, the key players are introducing innovative drug delivery systems like new gel-based formulations, vaginal estrogen drugs, and estrogen patches. This, along with aggressive marketing, direct selling campaigns, and further investment by manufacturers, is anticipated to bolster the market growth.

Market Summary:

On the basis of the product type, the market has been divided into estrogen, human growth hormone, testosterone, thyroid, and other replacement therapies. Among these, estrogen replacement therapy is leading the market.

Based on the route of administration, parenteral accounts for the majority of the total market share. Other segments include transdermal and oral.

On the basis of the type of disease, the market has been classified into growth hormone deficiency, hypothyroidism, menopause, male hypogonadism, and others. At present, menopause holds the biggest market share.

Region-wise, North America represents the leading market, owing to the increasing cases of hypogonadism among the geriatric population. Other regions include Latin America, Europe, Middle East and Africa, and Asia Pacific.

The competitive landscape of the market has been analyzed in the report, with some of the key players being Novo Nordisk, Pfizer, Abbott Laboratories, Bayer AG, Hisamitsu Pharmaceutical Co. Inc., Merck, Eli Lilly & Company, Roche, Mylan, and Novartis.

View Full Report with TOC & List of Figure: https://www.imarcgroup.com/hormone-replacement-therapy-market

As the novel coronavirus (COVID-19) crisis takes over the world, we are continuously tracking the changes in the markets, as well as the purchase behaviours of the consumers globally and our estimates about the latest market trends and forecasts are being done after considering the impact of this pandemic.

About Us

IMARC Group is a leading market research company that offers management strategy and market research worldwide. We partner with clients in all sectors and regions to identify their highest-value opportunities, address their most critical challenges, and transform their businesses.

IMARC’s information products include major market, scientific, economic and technological developments for business leaders in pharmaceutical, industrial, and high technology organizations. Market forecasts and industry analysis for biotechnology, advanced materials, pharmaceuticals, food and beverage, travel and tourism, nanotechnology and novel processing methods are at the top of the company’s expertise.

IMARC Group

USA: +1-631-791-1145

Email: [email protected]

#Hormone Replacement Therapy Market Hormone Replacement Therapy Market Share

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blackfridaysale · 4 years

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Signal Relief Patch Reviews – Pain Patch launched

Have you ever imagined having a device that can turn off your pain within minutes? What about one that doesn't use chemicals? Signal Relief is a special wearable patch that quickly relieves pain in any part of your anatomy. Without a doubt, pain affects the quality of life. Many times you may prefer to lie down with the hope that the pain will naturally go away.

Most pain plasters available in the market do not provide immediate or desired results. Most jobs now require individuals to sit for over eight hours. Therefore, chronic, long-lasting pain is something that many people have to deal with. Although most people use over the counter drugs to deal with pain, we are starting to look for alternatives. The ineffectiveness and side-effects are pushing people towards more natural alternatives. Who can blame them?

What Is Signal Relief?

Signal Relief is a pain patch that utilizes nanotechnology and pain modulation methodology to relieve pain naturally. One thing that makes this approach unique is that it does not require oral injection or cream. Signal Relief helps the nerve system communicate with the natural system to reduce the requirement for drugs. In most cases, pain is one way our nervous system communicates with us to say something is wrong. However, sometimes, they get mixed up.

This revolutionary pain relief does not require any prescription or manual to use or ensure its validity. Furthermore, you can place the patch anywhere where you feel pain or discomfort. The results are fast, too. They will take mere seconds to relieve pain.

The patch will block the electro signals from areas of pain reaching the brain. The Signal Relief technology has demonstrated communication between various organs using reliable electric signals.

How Does The Pain Patch Work?

Signal Relief is designed to work directly with the natural electrical system in your body. Yes, we all have internal electrical connectors! When you have pain, electrical signals move quickly to notify the brain. That is when you feel pain. The problem is, sometimes, that pain is unnecessary. The Signal Relief pain approach is often referred to as the modulator methodology. They are embedded with millions of tiny pieces that work with our natural electrical system to turn down pain from the brain to make you feel better.

The patch is super easy to use. When you feel pain in any part of the body, all you need to do is stick the Signal Relief patch on it. You will immediately start feeling the effects happening. The feeling is different from one person to another; while pain stops for most people, others feel warm relief in the affected part.

Whether you have developed chronic back or back pain, Signal Relief can change the way you feel entirely chemical-free; all you need to do is put it on the affected part. Signal patch works too first without any side effects.

Each unit comes with an adhesive pack applied to the patch's back for seamless application. If the adhesive fails to stick, wipe it down with a damp cloth and let it dry; doing that will make the patch regain its stickiness. If you dislike it touching your skin, you can stick the patch outside your clothes or bandage.

Beneficial Features of Signal Relief

The Signal Relief patch has various features that help provide pain relief within seconds after sticking it to the affected area. The design, creative process, and manufacturing are made in the US. It relieves all pain types, including knee, back, elbow, foot, and any other type of pain in the body. Here are some of the features associated with Signal relief:

Instant relief: As indicated on the product's official website, Signal Relief brings desirable results within minutes after sticking it to the affected part. This is made possible by the pain modulator methodology used.

All-natural: Signal Relief has no side effects and is drug or chemical-free; neither does it have a battery to support its activity.

Long-lasting: The flexible, reusable, and durable design allows one unit of Signal Relief to withstand many years of use. Therefore, you save a lot of money in the long run.

Waterproof: The Signal Relief patch is exceptionally durable and can hurdle extreme weather conditions. Therefore, pain relief can be worn during training sessions, showers, or even in a swimming pool, making it an exceptional product.

Long-term benefits: Many a customer of this product have come out to attest that the patch provides pain relief and makes their discomfort disappear permanently. It is essential to wear it as recommended by the manufacturer to get its maximum benefit.

Why Signal Relief Is The Best Choice for You

As you already know, this product's origin is in the United States and are pain relief patches with nanotech technology. Designed with waterproof polyester and dielectric material, you have no issues using it anywhere, whether in the pool or shower. The technology functions through electrical impulses activated through smallest particles to reduce inflammation naturally.

Its unique design allows you to place it in any part of the body, assisting you in obtaining near-instant relief whenever you require it. Moreover, Signal Relief has proved to have no side effects or addictive effects. Here are some of the reasons why Signal Relief is one of the most preferred pain relievers in the market.

1. Easy to Wear

Signal Relief is easy to wear, durable, waterproof, and can be used over lightweight clothing or placement accessories. The manufacturer has incorporated a non-transdermal feature to help a customer apply it directly to the skin. Most medical pundits have recommended this method as the best and the most efficient.

2. Technology

The technology used to build Signal Relief is similar to those commonly used by high-tech companies like signal transmission, bio-identification, and antennas. Over time, this technology has increased communication between the area in pain and the brain using reliable electrical signals.

3. No Wires or Batteries

The mention of electrical forces makes anyone think you need batteries or wires, which is not entirely true. Signal Relief works by using body energy to help pass electric signals from one part to another.

4. Money-Back Guarantee

To help assure customers of quality, this product's manufacturer offers a 30-day money-back guarantee. That means that you can see how it helps you to live pain-free, even from chronic pain, without the worry of losing money. However, to receive this offer, you should return the original invoice with the bio antenna.

The Workings of Signal Relief

Pain is an uncomfortable sensation or feeling experienced in any part of the body. However, the pain intensity often depends on the brain's ability to transmit electro signals to the brain. The simplest and the most logical way to prevent pain sensation is to block these electromagnetic signals in the most natural way possible.

The nanotech patch is a reliable solution to ordinary discomfort or inflammation. Most people are looking towards Signal Relief as an alternative to conventional pain medication. The patches are an excellent option for individuals looking to relieve pain and thoughtful of traditional medicines' addictive effects or life-threatening traditional medicine.

The patented Signal Relief technology employs nano technics to block any kind of pain at its origin. Through this, the user will experience natural comfort everywhere, especially the body's affected part, all without drugs. By now, you should have realized that Signal Relief does not have any side effects, and you can use it every day, for years if you have to.

Where else can you find such cheap pain relief patches that are simple to use and can be used in several parts of the body at the same time? Most users have attested that the Signal Relief works to relieve pain in less than one minute. Place the patch on the affected part and wait to see for yourself.

If handled carefully, the patch can be used for many years thanks to its reusable gums, changed within 3 to 7 days.

Signal Relief Reviews

According to the information from other reviews, the pain patches are intended for anyone with pain. The quality of life is severely affected in pain, and the manufacturer of this product made it their business to come up with a simple patch that can be used individually when in pain. It can be used directly on the skin or clothing, depending on your preference.

These pain relievers have been available in the market long enough and have proved effective. Unlike patches that radiate heat or active ingredients, Signal Relief pain patches use nanotechnology, which has zero effects on allergy people. One particular advantage of this product is that you can use it more than once, saving you money that you would usually spend on over-the-counter drugs every time you feel pain.

Many customers of this product appreciate that the only thing needed for multiple uses is cleaning its back. If placed directly on the skin, the pain will be relieved a few minutes later; however, placing the pain patches on top of the cloth will take a longer time to take effect. What this means is that you should put the patch on top of the skin for faster development.

Where Can I buy Signal Relief?

You can choose to order Signal Relief in various online stores or directly through the manufacturer. However, there is a significant risk of buying this product on other platforms other than the manufacturer since you risk purchasing counterfeit patches. The patches could look similar at a glance but will certainly not give the same effect. Therefore, the best way to do it is to make your order through the manufacturer's website.

Another advantage of buying this product directly from the manufacturer is that you will get a lot more information about the product and get the best out of it. Additionally, the manufacturer offers customers multiple payment options.

After placing your order, your delivery will only take a few days to reach you. If you feel dissatisfied with the product, you have a chance to return it within 30 days after receiving it, and your money will be refunded as soon as the product reaches the manufacturer. Visit the official website here to find a discounted price!

Final Thoughts

Based on the analysis shown above, Signal Relief amplifies electrical signals from the body to the brain. Everything about the relief patch is natural, free from drugs or chemicals. Therefore, the pain patches are appealing to those thinking of moving away from over the counter drugs. Many people, especially first-time users, are skeptical of drugs that must contact the skin; the good news about signal patches is that they work equally well when placed above the clothes.

If you experience chronic pain, you should certainly see how well this works to improve your life quality for years to come.

#signal relief vs kailo #signal relief patch review #signal relief patch amazon #signal relief adhesives #signal relief reddit #signal relief jovi #signal relief patch australia #signal relief patch reddit

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elmrisrayv · 4 years

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Just Check Out Key Details About Kailo

It's extremely challenging for many of us for you to take suffering of child birth mind blowing nutritional supplements definitely. The very first disadvantage to making use of prescribed analgesic tablets is this can break the failing liver and even abs designs mainly because we need to take each of these nutritional supplements more often. Prescribed analgesic capsules get fix some time to find the effective alleviation good results. However, there is available using a new non-transdermal patches which happens to be with regards to the solutions from nanotech bio antenna. Most of these patches stick to your epidermis for decades plus often times supplies a regular flow in get rid of all of the problematic distress factors. This technology is helpful for plenty of pain and discomfort health conditions as well as menstruating problems, osteoarthritis, together with multiple sclerosis. All of these patches are likewise beneficial in lowering the problem out of the supplies of puffiness. Research has shown that you have several benefits using this pain relief patches love permanent delivery service with medicine within the affected region, low uncomfortable side effects, nearby anti-inflammatory pursuit, together with nearby relief, for example.

A majority of these patches should be considered into the wrists, back of the neck, lower back, lower thigh, behind the knee, inside the bicep, shoulder, additionally, the foot relatively comfortably. All those discover a lot of options within the market regarding the pain sensation assistance patches wherein kailo reviews this branded tactic. Often the kailo pain patch is definitely a recyclable patch in accordance with nanotechnology who marks the specific area plagued by ache. The principal discuss involving kailo patch technology is that hot weather won’t produce all problematic side effects simply because patch right blows the discomfort erasing electrical signals straight into the mind. This pain-relieving technology is truly solid and then in and around $3.5 million from marketing are actually completed up to the point currently. The very kailo nanotech patch is absolutely just as the a trainer who is found in acupuncture which is where increased nanotechnology may be used on the non-invasive and even remunerated alleviation strategy. For more information when it comes to kailo patch review, buyers have the ability to click the link and additionally demand webpage.

These types of kailo pain relief patches utilise the the most effective method a patch will act like an antenna that helps these a lot faster communications in pain-related signals. People don’t should also be loaded periodically and you will find three adhesives in every kailo nanotech patch. A few kailo pain relief reviews counsel that your patches can be very hard wearing, readies skin plus dress, allow virtually instant comfort inside 60 - 120 seconds, not to mention water. The very kailo cost is without question $120 and then presently, these could possibly get all these patches to find $99 basically. Men and women will gain shipping despite the volume of patches purchased. They may also read the price reduction includes whenever they need it all of the patches in scores. Find out more about associated with does kailo work, visitors may go here or see a web.

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terynhon · 4 years

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Let’s Get Aware About special kailo Pain Patch

Anguish is really a modern world plague now. For your business reacting so that you can painfulness differs from the others comparable to most people just take medications, numerous just take relief of pain supplements, many cure that by way of performing holistic health combined with drills. The best powerful options for pain alleviation is considered the by using pads. A good solid transdermal piece is actually a item which usually fastens to any pores and skin along with transfers drugs into the individual promptly. The facial skin ingests the drugs in excess of some time when the applying many of these nicotine patches. It's just a really simple course of action as an alternative to treatment along with anabolic steroid pills. There's a variety of businesses that make them available by all the patches. A few, kailo has become the top available choices that are available. A good solid kailo pain patch is pretty comfortable especially results perfectly one should wear it effectively. Anyone online can utilize the kailo patch in any part with the shape mainly because it minimizes joint, knee problem, arm pains, sciatica, muscular anguish, etc. There exists a considerable need for this instant pain and discomfort ameliorating technique as being kailo pain relief patch precisely deals with areas connected with painfulness just by liberating the drugs down into complexion. Choosing kailo pain relief patches you'll be able to salvage a bunch of money this really is allocated to highly-priced pain-relieving devices in addition to treatments. If you want to appreciate does kailo work correctly or otherwise, it is possible to go over this text. These kailo pain relief patches depend on nanotechnology that is certainly regulated through the nano capacitors the talk mental performance to ease ache so item known as for the reason that kailo nanotech patch. The actual kailo pain relief patch delivers precisely together with the mental faculties because of dispatching tells for that anguish deteriorating organ that avoids all of the miscommunication and finally takes away anguish. For additional information related to kailo pain relief reviews, you possibly can follow this link and even click on the web site.

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There are lots of advantages of using kailo patch like simple system, rapid assistance, impermeable, 0 complications, multi-time intake, etc. Clientele shall be so long as some recycleable kailo due to three positive recycleable glue together with a fluffy scenario to cart these items comfortably. The exact kailo shields can be utilized anywhere from around everyone however if any individual is actually ordering soon coming from the United States next these kind of is going to be transported free. A kailo offers the services equipped with USPS service that wrecks Monday to Friday and delivers Monday to Saturday. You can find fraudulence and also content solutions and products you can buy to ensure you has to obtain on the established webpage in kailo. Individuals will also get a 100% money-back warranty in the instance of unhappiness during 90 days associated with transport. Prospects can potentially track the actual does in the exact location within the course of action. To find out more relating to kailo reviews or package particulars, you can travel to this website.

#kailopainreliefpatch

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goodthaiganja-blog · 5 years

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Many THC and CBD oil Proceeds to waste on your body--here Is why

In the event that you understood that just 6 percent of your CBD gummies will put in your blood to perform their job, do you purchase them? Bioavailability refers to the amount and speed at which a chemical is absorbed into your blood for use where required. Physiological processes and ingestion methods can impact cannabis absorption, making its consequences marginally hit-and-miss. It is essential to get clued up on bioavailability so as to make the most of the medicinal potency of cannabis. The more bioavailable your cannabis, the lower the amount of this plant you want to reap its advantages. What variables affect cannabis bioavailability? The spike in cannabis popularity could be partially attributed to the assortment of consumption methods out there. Edibles and tinctures may have less of this stigma traditionally associated with joints. But when cannabinoids like CBD and THC are consumed in petroleum form--oil can also be utilized to produce edibles--their bioavailability becomes endangered. CBD and THC oils resist absorption into the blood because the body is left up to 60% water. Standard science--and salad dressing--dictates which water and oil don't mix, and the exact same goes for cannabis oil along with the body. "Cannabinoids are fat-loving molecules and need to traverse a mobile environment that's aqueous or watery," clarifies Dr. Patricia Frye, a member of the Society of Cannabis Clinicians and chief medical officer at Hello MD.. When cannabis is absorbed as a oil, the start of effects can get postponed and bioavailability restricted. Another occurrence which restricts oil-based cannabis extracts from hitting the blood is your first-pass effect. When cannabis is consumed orally, it's absorbed from the gastrointestinal tract and transported through the portal vein into the liver, where it's metabolized. As a consequence of this procedure, only a limited quantity reaches on the circulatory system. Considering that cannabis oil is frequently taken orally, its effectiveness could be hindered.

Are a few cannabinoids more bioavailable than others? There's been some research into CBD, THC, and much less into cannabinol, or CBN. Various studies have demonstrated that the bioavailability of cannabinoids depends upon the process of shipping. Once employed as a topical ointment or transdermal patch, CBD can permeate the tissue ten times more efficiently than THC. The exact same is true of CBN. THC, however, is much more bioavailable than CBD when administered orally or delivered through the lungs. A clinical study found that levels of THC from the blood appeared 30-50percent higher than CBD subsequent oral ingestion as a sublingual spray. But, the bioavailability of THC remains restricted when absorbed orally, averaging just 4-12%. When smoked or vaped, the bioavailability of THC jumps into a mean of 30 percent. By submitting this form, you'll be subscribed to promotional and news mails from Leafly and you also consent to Leafly's Conditions of Service and Privacy Policy. It is possible to unsubscribe from Leafly email messages everywhere. Which approaches for cannabis consumption optimize bioavailability? One of the most frequent and suitable cannabis products, like capsules, soft gels, tinctures, and edibles, restrict bioavailability as a result of very first pass through the liver. "Just about 6 percent of the dose is consumed. The onset of action could be as long as 6 hours; it is quite simple to take a lot of, and the consequences could last as long as 20 hours" Cosmetic administration lasts more than smoking, eliminating the need for frequent dosing. Cosmetic methods additionally prevent irritation to the airways and the probability of malignancies related to smoking or vaping. Having said that, inhaling cannabis guarantees enhanced bioavailability because atoms are carried by vapor particles right into the alveoli in the lungs. This permits cannabinoids to quickly enter the blood without being metabolized by the liver. The spike in cannabis popularity could be partially attributed to the assortment of consumption methods out there. Edibles and tinctures may have less of this stigma traditionally associated with joints. But when cannabinoids like CBD and THC are consumed in petroleum form--oil can also be utilized to produce edibles--their bioavailability becomes endangered. CBD and THC oils resist absorption into the blood because the body is left up to 60% water. Standard science--and salad dressing--dictates which water and oil don't mix, and the exact same goes for cannabis oil along with the body. "Cannabinoids are fat-loving molecules and need to traverse a mobile environment that's aqueous or watery," clarifies Dr. Patricia Frye, a member of the Society of Cannabis Clinicians and chief medical officer at Hello MD.. When cannabis is absorbed as a oil, the start of effects can get postponed and bioavailability restricted. Another occurrence which restricts oil-based cannabis extracts from hitting the blood is your first-pass effect. When cannabis is consumed orally, it's absorbed from the gastrointestinal tract and transported through the portal vein into the liver, where it's metabolized. As a consequence of this procedure, only a limited quantity reaches on the circulatory system. Considering that cannabis oil is frequently taken orally, its effectiveness could be hindered. Are a few cannabinoids more bioavailable than others? There's been some research into CBD, THC, and much less into cannabinol, or CBN. Various studies have demonstrated that the bioavailability of cannabinoids depends upon the process of shipping. Once employed as a topical ointment or transdermal patch, CBD can permeate the tissue ten times more efficiently than THC. The exact same is true of CBN. THC, however, is much more bioavailable than CBD when administered orally or delivered through the lungs. A clinical study found that levels of THC from the blood appeared 30-50percent higher than CBD subsequent oral ingestion as a sublingual spray. But, the bioavailability of THC remains restricted when absorbed orally, averaging just 4-12%. When smoked or vaped, the bioavailability of THC jumps into a mean of 30 percent. By submitting this form, you'll be subscribed to promotional and news mails from Leafly and you also consent to Leafly's Conditions of Service and Privacy Policy. It is possible to unsubscribe from Leafly email messages everywhere. Which approaches for cannabis consumption optimize bioavailability? One of the most frequent and suitable cannabis products, like capsules, soft gels, tinctures, and edibles, restrict bioavailability as a result of very first pass through the liver. "Just about 6 percent of the dose is consumed. The onset of action could be as long as 6 hours; it is quite simple to take a lot of, and the consequences could last as long as 20 hours" Cosmetic administration lasts more than smoking, eliminating the need for frequent dosing. Cosmetic methods additionally prevent irritation to the airways and the probability of malignancies related to smoking or vaping. Having said that, inhaling cannabis guarantees enhanced bioavailability because atoms are carried by vapor particles right into the alveoli in the lungs. This permits cannabinoids to quickly enter the blood without being metabolized by the liver. Another lesser known technique of management would be intranasal delivery, which empowers cannabinoids to be readily consumed with a quick onset of ten minutes or not. "Intranasal approaches are highly bioavailable at 34-46%," says Frye. "it is a particularly beneficial manner of delivery for individuals that are having a seizure or for individuals hoping to abort an impending seizure or migraine." Transdermal patches may be super capable of targeting systemic or localized pain. They enable a continuous infusion of active ingredients into the shipping site, so the individual is not likely to experience spikes of THC from the blood. Ultimately, nano-emulsions and micro-emulsions can radically boost the stability and bioavailability of cannabinoids. These novel formulations utilize nanotechnology to provide around 100 percent bioavailability. Frye warns, however, the study remains scarce. "We do not understand the complete scope of these manipulations impact cannabinoid activity in the cellular level," she states. What tips or suggestions might help boost bioavailability? One means that fosters the absorption of edibles would be to unite cannabis merchandise with fats. Frye recommends mixing edibles or tinctures with healthful fats like guacamole, hummus, or dark chocolate. If you are feeling less virtuous, nevertheless, ice cream functions as a cure. The same holds for alcohol-based tinctures. For people who smoke or vape, bioavailability may be improved by minimizing sidestream reduction and raising the amount of puffs. "With a handheld or desktop vaporizer with blossom will remove sidestream losses," Frye advises. If you believe you get more bang for your dollar by holding your breath, then think again. "There is not any evidence supporting holding the breath for over 10 secs," says Frye. Some final words of guidance in Dr. Fyre, for individuals seeking to maximize cannabis bioavailability:"The very cost-effective approach to use cannabis isn't to utilize more than you want. Less is more," she states. Owing to the biphasic character, excessive dosing can exacerbate the symptoms you are trying to relieve. Read the full article

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Nano-silicon Drug Delivery Platform Market Forthcoming Developments, Business Opportunities & Future Investments

Safe and effective drug delivery is a major challenge against the pharmaceutical and biotechnology companies. Companies formulate their drugs in various dosage forms such as capsules, powders, inhalers, liquid, drops, tablets, transdermal patches, depot injection, and gels to address the drug delivery challenges in different conditions. Moreover, advancement in research has enabled controlled and sustained release of drugs to decrease the dosage and provide long term effect of the drug. Furthermore, new technologies such as nanotechnology and antibody-drug conjugate are being introduced to minimize cost and increase bioavailability. In all, there is all-together a new wave of innovation in life science sector that delivers medicines at the targeted site in right dose.

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Potential Applications

SiSafe will be of significant use to pharmaceutical, animal health, biotech and cosmeceutical companies to formulate and package drugs that are difficult to formulate otherwise. Companies finding better solutions for their existing drugs can incorporate this technology to improve their product quality. Also, new drugs used for chronic diseases can be delivered at a low dose to the target sites with the nano-silicon drug delivery platform.

Nano-silicon Drug Delivery Platform to enable Low Cost Drug Delivery

Research for the use of nano-silicon particles in targeted tumor therapy is under progress. The study being conducted by various organizations globally including Tel Aviv University, Technion – Israel Institute of Technology in collaboration with Massachusetts Institute of Technology (MIT) and the Harvard Medical School are of the opinion that nano-silicon particles could deliver drugs over a long period of time, may be for weeks or even months. Such advancement in drug delivery technologies will revolutionize the pharmaceutical and biopharmaceutical drug industry by offering targeted drug therapies at a low cost.

#Nano-silicon Drug Delivery Platform Market #Nano-silicon Drug Delivery Platform #Nano-silicon Drug Delivery Platform Market 2026

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affiliatetejas · 4 years

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Nano-Silicon Drug Delivery Platform Market 2026

To Gain More Insights into the Nano-Silicon Drug Delivery Platform Market, Browse Summary of the Research Report –

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Nanotechnology-based platforms are gaining significant importance in research and product development due to the enormous benefits they offer in terms of drug stability, bioavailability, dosage, and shelf-life. Various types of nano-carriers or nanoparticles such as liposomes, magnetic particle, dendrimers, silver nanoparticle, silica nanoparticle, and polymeric micelles, carbon nanoparticles and drug-conjugate nanoparticles are used in different industries to cater the exact need or product.

SiSaf’s new drug delivery technology called SiSafe is a patented elemental nano-silicon porous structure with a massive surface area. A higher surface area provides high drug-loading capacity and thus significant increase in bioavailability of even the most hydrophobic compounds. So, a less soluble drug that needs to be injected directly in the bloodstream can have enhanced solubility through SiSafe nano-silicon platform. Molecules are incorporated within the nanopores, thus stabilizing the instable molecules and increasing the bioavailability of the drug. SiSafe is a biodegradable technology which enables customizing the rate of onset and release by altering the physical factors of the carriers such as linkage method, porosity, particle size, and pore width.

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Top players in the market

Several institutes are focused on R&D related to nano-silicon drug delivery approaches. For instance, in August 2019, researchers from Icahn School of Medicine at Mount Sinai conducted a clinical trial for gold-silica nanoparticles-based photothermal cancer therapy.

Similarly, in June 2019, researchers from Georgia Institute of Technology reported development of silica spheres of around 200 nanometers in size that can be used for drug delivery to eliminate malignant cells only in certain parts of the body, in the journal Angewandte Chemie International Edition.

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Bill Gates and Intellectual Ventures Funds Microchip Implant Vaccine Technology

Posted on: Tuesday, April 14th 2020 at 5:30 am

Written By: Celeste McGovern

This article is copyrighted by GreenMedInfo LLC, 2020

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The Bill and Melinda Gates Foundation has donated more than $21 million towards developing a vaccine technology that uses a tattoo-like mechanism which injects invisible nanoparticles under the skin that is now being tested in a vaccine against the virus that causes COVID-19.

The microneedle technology is also being wed to injectable technology, funded by the Bill and Melinda Gates Foundation, which embeds under the skin a vaccination record visible by near infrared light that can be read by smartphone technology.

The Bill and Melinda Gates Foundation is funding the technologies with aims to enable them in “house-to-house” vaccine campaigns undertaken by people with “minimal training.”

Researchers from the University of Pittsburgh reported in their study published April 1 in EBiomedicine, a Lancet Journal, that their microneedle patch vaccine against the SARS CoV-2 virus that causes COVID-19 “prompted robust antibody production in the mice within two weeks.”

The patches resemble a spiky piece of Velcro, with hundreds of tiny microneedles made of sugar. The needles prick just into the skin and quickly dissolve, releasing the vaccine into the tiny abrasions and inducing a potent immune cell response despite the minute amount of the vaccine material – far more potent than an intramuscular injection.

The researchers had been testing vaccine using the microneedle patch for other coronaviruses, including the one that causes Middle East Respiratory System (MERS) and reported that three different experimental MERS vaccines induced the production of antibodies against the virus. These responses were stronger than the responses generated by regular injection of one of the vaccines along with a powerful immune stimulant (an adjuvant). Antibody levels continued to increase over time in mice vaccinated by microneedle patch—up to 55 weeks, when the experiments ended. The researchers have now turned their technology to the COVID-19 virus, SARS CoV-2.

“Testing in patients would typically require at least a year and probably longer,” senior co-author of the study, dermatology professor Louis Falo said. “This particular situation is different from anything we’ve ever seen, so we don’t know how long the clinical development process will take. Recently announced revisions to the normal processes suggest we may be able to advance this faster.”

Another study funded by the Bill and Melinda Gates Foundation and published in December, 2019 by researchers from the Massachusetts Institute of Technology, the Institute of Chemistry of the Chinese Academy of Sciences in Beijing and the Global Good, Intellectual Ventures Laboratory in Bellevue, WA, describes how “near-infrared quantum dots” can be implanted under the skin along with a vaccine to encode information for “decentralized data storage and bio-sensing.”

“To maximize the utility of this technology for vaccination campaigns, we aimed to create a platform compatible with microneedle-delivered vaccines that could reliably encode data on an individual for at least five years after administration,” said the MIT paper, titled Biocompatible near-infrared quantum dots delivered to the skin by microneedle patches record vaccination. “In addition, this system also needed to be highly biocompatible, deliver a sufficient amount of dye after an application time of 2 min or less, and be detectable using a minimally adapted smartphone.”

Fridrik Laurusson, an author of the microchip study, is from The Global Good, Intellectual Ventures Labarotory. Its website features Microsoft founder Bill Gates on its front page and describes itself as a “collaboration between Bill Gates and Intellectual Ventures” a company founded by Nathan Myhrvold and Edward Jung of Microsoft. Wikipedia describes Intellectual Ventures in Gates’ home state as a private American company that “centers on the development and licensing of intellectual property” and “one of the top-five owners of U.S. patents, as of 2011.

“Its business model has a focus on buying patents and aggregating them into a large patent portfolio and licensing these patents to third parties,” according to Wikipedia. The company has been described as the country's largest and most notorious patent trolling company, the ultimate patent troll, and the most hated company in tech.

The company has been described as the country's largest and most notorious patent trolling company,[2] the ultimate patent troll[3], and the most hated company in tech.[4]

The website of the Bill and Melinda Gates lists multiple grants awarded to develop the “microneedle array patch” – for use in “house-to-house campaigns via administration by minimally-trained personnel.”

The most recent grant for $370,035 was awarded in February, 2020 to the Centers for Disease Control and Prevention for an MMR vaccine patch that does not require refrigeration and “enables house-to-house campaigns” via people without medical experience or training.

Bill Gates has awarded much larger grants for microneedle array patch technology to companies and organizations including:

* Vaxxas Pty Ltd in Brisbane, Queensland ($4.99 million in November, 2019) to develop a “microneedle array patch for measles and rubella vaccination that enables house-to-house campaigns via administration by minimally-trained personnel”

Vaxxas was created in 2011 after Mark Kendall's research group at the University of Queensland commercialized the nanotechnology under the company, UniQuest. The company has raised more than $35 million for the nanotechnology. It’s partnered with vaccine manufacturer Merck – a company whose drug Vioxx caused more than 27,000 deaths by heart attack before the company revealed the risks it had hidden from the public. Merck has repeatedly been accused by judges for “egregious” ethical breaches and of “improper testing and data falsification” on its Gardasil HPV and MMR vaccines. Merck made

Micron Biomedical Inc ($6,744,906 in November, 2019) “to develop a microneedle array patch for measles and rubella vaccination that enables house-to-house campaigns via administration by minimally-trained personnel”

Georgia Institute of Technology ($958,849 in December, 2019) “to develop a microneedle array patch for measles and rubella vaccination that enables house-to-house campaigns via administration by minimally-trained personnel”

Vaxess Inc, ($2,967,741 in November, 2016) in Boston, MA “to support the preclinical development and manufacture of a thermostable microneedle patch with the aim of lowering barriers to vaccine access by simplifying dosing and administration, alleviating cold chain constraints, and lowering costs

Cardiff University ($$3,570,376 in December, 2019) “to develop a dissolvable microneedle array patch for the sustained dermal delivery of a progestin contraceptive, including the conduct of preclinical proof of concept studies”

Gates began funding the implantable biotechnology back in 2011 via a small ($100,000) grant to the Santa Cruz based company TransDerm Inc whose Linkedin page links to a website for the pharmaceutical giant Allergan.

Last month Reuters news service reported – falsely -- that a popular Facebook post about Bill Gates planning to use microchip implants to fight the coronavirus pandemic was a “false claim.” The news service linked to the censored Facebook post.

Gates, whose father was the director of Planned Parenthood Federation of America and mother worked for PPFA’s funding affiliate United Way, has been noted for his population control ideology. His wife, Melinda Gates, launched a Family Planning Summit on World Population Day in 2012 with the aim of garnering tax dollars from governments to expand reproductive health services aimed at lowering the global birth rate.

Difficult questions about vaccines are on BOTH sides of this huge debate. Find out the pros and cons and get the knowledge to make your own informed decision. Don't miss The Truth About Vaccines happening April 22-30.

Celeste McGovern is an award-winning independent journalist in Scotland. She reports on medical news, drug scandals, alternative health and more at www.ghostshipmedia.com.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of GreenMedInfo or its staff.