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[bonnienapierfilm]

POPPER [wt] - Writing Pt.1

hello hello hello

I am writing and directing a grad film! so scary but as it turns out actually not so scary if you got a wonderful team and people who understand you!!

As you can see in my previous posts, the idea for the film centred around Thalidomide, which was a drug for pregnant ladies in the late 50s that caused a lot of birth defects and miscarriages. An overall horrible story. Once my writing tutorials began with Kate, we came to the conclusion that a film with surreal elements and dream sequences might be in bad taste, or simply a story that I don't feel I could do justice or tell effectively. So Thalidomide is no longer the focus of my film, though still something I draw inspiration for.

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Ahhhh! It's a commentary ladies and gentleman, buckle in for another napier feminist piece...

Jokes aside, this film means a lot to me. As a women who relies on the medical industry {eczema whoop whoop} and has felt mistreated most of the time, this is a story I want to tell. I know so many girls who have had terrible experiences with getting the morning after pill, being faced with rude people who have no empathy whatsoever. Additionally, our birth control, is the same one they have been giving out for YEARS. A little pink packet of seemingly harmless and helpful pills comes with an abundance of side effects. Tis' a big fat shame and I wanna make a film about it.

Following this will be all my writing documents and tutorial notes with Kate.

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[ochabestgirl]

I have so many good ideas and prompts for fanfiction, and I HAVE tried my had at writing, but it never turns out how I’m wanting it to. I would love for an experienced fanfic writer who loves kachako, to maybe feel inspired to write a specific prompt that has been in my head for years.

So the story starts out with an established Katsuki and Ochako relationship.

Ochako hasn’t been feeling her best, with fatigue and weakness, wt loss, easily getting winded which has been putting a dent in her hero training. Ochako has never wanted to be a burden on anyone, so she keeps how she’s been feeling to herself, brushing off any concerns from her friends and teachers, saying she’s just been overworking herself as an excuse.

Things then take a turn for the worst when she passes out after giving blood at the yearly blood drive that pops up at UA every November. Nobody really thinks anything of it, since it is a normal reaction to donating blood. She wakes up in recovery girls office 4 hours later with a passed out Katsuki in the chair next to her bed. He wakes up and is worried but she eases his worries and sends him back to his dorm room after recovery girl comes in to check up on her. Once their alone, she informs her that after running a few tests on some of the blood she had donated, they discovered that her labs showed an increased in the number of leukocytes which point to one think, leukemia.

Recovery girl wants her to run more tests and have a bone marrow biopsy to confirm and come up with a treatment plan but Ochako is in denial. She can’t possibly accept the fact that all her hard work the last two years at UA could all be for nothing, so she goes harder than ever and does her best to hide it from everyone, including Katsuki.

After getting pared up with Kirishema for a class hero project, Ochako starts having worse symptoms, like bleeding gums and nose bleeds. Recovery girl says that this is a sign of worsening leukemia so she gives her an ultimatum, she either go’s to get her biopsy done or she was going to tell Her teachers, HIPAA be damned.

Reluctantly she agrees, but on the days following, Kirishema notices that she’s been slacking and feels frustrated to be the only one doing the work. On the day of her biopsy, she dips out of training early. Kirishema, having had enough, confronts her saying it wasn’t fair to him if she wasn’t going to take their assignment seriously. Ochako ends up having a compleat meltdown saying, “ you wanna know what’s not fair, I have cancer!” Kirishema in shock tries to respond but she cuts him off “ I’m going to my first bone biopsy today, that’s why I had to leave early, I’m going through this alone, but I’m sorry if all of this is an inconvenience to you!” Tears rolling down her face she turns on her heals and walks away, leaving Kirishema standing there speechless.

After a few moment he takes off to recovery girl desperately looking for answers, now extremely worried about his friend. He grills her for answers. Recovery girl, not able to give him much information, tells him what she can. That Ochako isn’t wanting to tell anyone or be compliant, and where her biopsy is taking place.

Ochako is on the table and they are about to start but before they even take out the needle a nurse walks in and whispers something to the dr. He nods his head and the nurse leaves. She doesn’t thank anything about it, until the door opens and Kirishema walks in. She is confused. “I couldn’t let you go through this alone.” He says shrugging his shoulders with a wary look on his face and tears in his eyes.

He sits by her side holding her hand and brushing his fingers through her hair as she gasps and cries in pain. Tears both running down their faces.

* I don’t have much in between this part and the next. Mostly just Katsuki  worrying to death, seeing the bruising on Ochako body and the amount of weight she has lost, not to mention her lethargic behavior, and Kirishema wanting to tell him what’s been going on but not being able to because it wasn’t his place. Ochako swearing him to secrecy, wanting to be the one to tell him but not feeling ready, so she keep putting it off.*

Kirishema has enough when Ochako passes out during breakfast, right in the middle of eating. Katsuki beside himself with anxiety and worry, urging her to take it easy. Ochako looks at Kirishema, noticing the terrified look on his face and excuses herself to go to her dorm room, but not without giving her boyfriend a calming kiss saying she was going to take a nap. Katsuki watch’s her disappear through the elevator doors, with a hopeless look on his face. Kirishema has made up his mind and sneaks off after breakfast to confront Ochako.

They end up getting into an argument and Kirishema says that she has to the end of the week to tell Katsuki or he was going to and storms out of her room, leaving Ochako sitting on her bed staring off into space completely spent with the day already.

Katsuki comes up after cleaning up the dining area to find Ochako passed out rather uncomfortable looking on her bed. He adjusts her to where her head is on her pillow and draws the covers up over her shoulders. She is shivering so he looks for another blanket in her dresser drawers only to find a large plastic bag full of an assortment of colorful pills. (Ochako put them in a plastic bag so she could hide them better.)

Completely shook, thinking that Ochako has a drug problem, he takes the pills and leaves, and in typical Katsuki fashion with no warning or tact, confronts Ochako in the common room after dinner in front of all his classmates. Completely consumed with worry, frustration, anger, concern and sadness, he doesn’t even think that he probably shouldn’t have approached it the way he did, but he was too desperate to care.

He throws the bag of pills out on the coffee table in front of Ochako. “Care to explain why I found a bag of pills in your dresser?” He asks with so much tension he is shaking a little bit. “I should have noticed sooner, it makes so much since now.” He says to no one in particular.

“Katsuki it’s not what you think, let me explain, I….”

“Don’t even fucking lie Ochako, you’ve been lying to me for weeks, I’m sick of it damnit!” He is shaking uncontrollably now. “I’m telling Aizawa, and we’re getting you into the first rehabilitation facility we can find that has an opening!” He’s so unhinged that he doesn’t even notice the stunned looks of concern on his classmates faces.

“Ochako, is it true?” Mina asked with both hands cradled to her chest. “ If it is, we all love you and want to help you.”

At this point Ochako is slumped over with her face in her hands, trying to make herself as small as possible.

She had been sitting between Deku and Iida, who are now rubbing her back with worried looks on their faces. “Ochako we will get you help, everything will be okay.” Deku says with tears in his eyes and voice thick with emotion.

Ochako springs off the couch so fast it startles everyone. She’s pacing around the room, and the color looks to be drained out of her face. She’s breathing heavy with tears in her eyes, borderline panic attack mode. Katsuki’s face softens and he approaches her, arms lifting like he was going to try to calm her down.

Kirishema then decides to speak up “ Chako, I think now is the right time to tell him.”

Katsukis head snaps up and his eye meet the ones of his best friend. “What the hell are you talking about, you knew what was going on this whole fucking time, and kept it from me?!”

“It wasn’t my place to say anything bro.” Kirishema responded with regret.

Small explosions leave katsukis palms as he leaps over the couch grabbing onto Kirishema’s shirt getting a few punches in before Deku and Sero pull them apart. Katsukis is still thrashing trying to get out of Dekus grip.

“I have leukemia!” Ochako screams loud enough for everyone in the building to hear. She then falls to the ground curling into herself sobbing.

Everyone and everything just stops and everyone freezes, Kirishema is laying on the floor rubbing his face while katsukis just stands there, with a blank look on his face directed at Ochako.

“Leuko-what now??” Kaminari asks from his place beside Kirishema.

“But that’s” Deku starts “ That’s cancer right?”

A strangled gasp is heard from Tsyu, who is trying not to cry.

“How can this be? Your so young, you have your whole life ahead of you.” Iida says like he hasn’t processed the information yet.

This comment causes katsuki to spring to life, “ w-why the fuck are you still here then, we need to get you to a hospital! Som-someone go get recovery girl! Why are you all looking at me like I’m crazy! She needs to go to a fucking hospital!” He’s not pausing for breath and in a half second, he is crouching down next to Ochako, ready to pick her up and bolt to the closets hospital himself. “ W-whatever, I’m going to get Aizawa myself!”

“You can’t!” Ochako desperately clings to katsukis arm, both trying to ground herself and to stop him from leaving. “You cant tell anyone! N-none of you all can tell anyone.” She looks like a cornered animal.

Katsuki looks at her like she has grown a second head. “what the hell are you talking about?! Do you even get how serious this is?! You could fucking die Ochako!” He’s panicking now “ That is not a risk I am willing to take!”

Anger boiling up inside her she yanks her hands away and stands up, causing katsuki to fall over.

“This isn’t your decision ‘Bakugou!’” She seethes. “I have worked so hard and I have come so far! I can’t give all that up! I won’t!” She is standing so still, fist clenched and shaking slightly.

“Chako, you have to-“ Kirishema is silenced by Ochakos loud “No!”

“I don’t Have to do anything! This is my decision!” Ochako starts backing away, eyes darting around the room, obviously looking for an escape. “It’s my decision…” she whispers once more before she bolts to the door leading to the outside, having jumped over the couch in the process. By the time anyone had realized what had happened, she had already disappeared through the doors vanishing into the night.

The class explodes into a frenzy.

“What is going on down here.” Came the calm voice of their teacher from the elevator doors.

“Mr Aizawa…” Kirishema takes it upon himself to explain everything that had happened, all the while katsuki curls more and more into himself. He is still on the floor, head between his legs and hands in his hair.

Deku is close by, trying to talk to him but it is lost on def ears, he can barely make out the panic in his voice.

Trying to get control over his breathing he starts in though is nose and out through his mouth. He is filled with so many emotions he doesn’t know which one to focus on. Angry tears well up in his eyes, threatening to spill over.

He is aware of Kirishema’s face replacing Deku’s, and the ringing in his ears has stopped enough to hear him say that Aizawa, Mina, and , Tsyu have went after her.

He doesn’t remember when or how he winds up on the couch, and he doesn’t even care. He feels hands push him down so he is laying down with his feet propped up, and a cold washcloth is placed on his head.

By the time he starts to breath normally, he’s not sure how much time has passed. When he opens his eyes, he sees that some people were still lingering. Kirishema was sitting in a chair next to him with his head in his hands. Deku, Iida, and Todoroki were hovering by the door, looking for any sign of their return. Sero and kaminari sat on the love seat across from katsuki with sad, forlorn expressions on their faces.

When he slowly sits up, Kirishema lifts his head. Looking him dead in the eyes, katsuki asked, “Did all of that really happened? Is this really happening?” Katsuki hates how his voice cracks.

“ I’m afraid so.” Kirishema says gaze lowering to the floor. “ listen man, I’m sorry I didn’t tell you. It wasn’t my place.”

“ I understand why you didn’t. It’s okay.” Kirishema looked like he wanted to say something to that but suddenly the door opened.

Katsuki shoots up from his seat on the couch and faces the door.

Tucked underneath Mr. Aizawa’s arm was a rather small looking Ochako. Face puffy from crying, and bags under her eyes from exhaustion, she looked like the walking dead. Beside her with her arm locked with hers was Mina, face also a little read and puffy, Tysu bringing in the rear holding Ochakos shoes, despair written all over her face.

Ochako refused to look at anyone, even the remaining members of the so called “Deku squad.”

Katsuki makes a move to meet them at the door but one look from Mina makes him stop in his tracks. She shakes her head and mouths ‘not now,’ so not knowing what else to do he just stands there and dumbly watches them make their way to the elevator.

Katsuki tries to sleep that night, but can’t, his mind too full with visions of Ochako dying. Giving up he goes to his desk and opens up his laptop. He spends the next 3 hours researching leukemia, the survival rate, symptoms, causes, treatments, reactions to the medication, by the time the third hours came to a close it’s 2 am and katsuki has had enough. Without second guessing himself, he makes his way out the door, down the hall to Ochakos room and knocks.

It takes a few minutes before the door opens revealing a wide awake but an extremely exhausting looking girl he calls his girlfriend.

Her face contorts in pain and her eyes well up with tears when she sees him. “I’m so sorry katsuki” she sobs.

Without saying anything katsuki grabs her face with both of his hands and kisses her with the power of every emotion he had felt and is still feeling. Pushing her back into her room, he kicks the door shut. She’s on him in seconds, tears still leaking from her eyes as he kisses them away.

“I love you. I love you so fucking much cheeks.” It’s comes out as a choked whisper, like a plea for her to live. He’s got a lump in his throat but he pushes it down. She doesn’t need him breaking down too.

Ochako steps back for only a second to remove her shirt, then she leaps and wraps her legs around katsukis waist, opening up a whole other can of worms.

Not having any control at this point, he pushes her against the door, devouring her mouth like it was his only lifeline. “ I love you too! So much, I’m so sorry.” He silences her words with a Searing kiss. He moves them over to the bed and gently places her down. then settles himself on top of her. “Are you okay? I’m not hurting you am I?” He’s so afraid now.

“You could never hurt me.” She says with such certainty.

That night they gave themselves to each other in every way they could think of.

Him needing to feel her, to know that she was still alive and whole in his arms.

Her needing to feel alive and needing reassurance that she wasn’t alone in this, needing to feel close to the one she loves.

*So that is all I have so far. I do have some thoughts about her treatment and how katsuki struggles with watching her suffer. I would like the story to include weather or not Ochako makes it. But I’ll leave that up to whoever wants to take this story on. Also feel free to write smut if you want. I’m just not good at that, so I didn’t include it.

Please let me know what you all think and if you can make this fic come to life.

Disclaimer: Art is not mine! I got it off of google search. All credit goes to the artists.

[bestshoptheday]

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The $72B United States Weight Loss & Diet Control Market, 2019

New Post has been published on https://bestrawfoodrecipes.com/the-72b-united-states-weight-loss-diet-control-market-2019/

The $72B United States Weight Loss & Diet Control Market, 2019

DUBLIN, July 19, 2019 /PRNewswire/ — The “The $72B United States Weight Loss & Diet Control Market, 2019″ report has been added to ResearchAndMarkets.com’s offering.

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The U.S. weight loss market is now worth a record $72 billion, but the number of dieters has fallen, due to the growth of the size acceptance and body positivity movement.

Do-it-yourself plans still abound as consumers use free diet & fitness apps. Consumers are shunning processed foods and artificial ingredients, but frozen food makers have adjusted and sales are showing signs of growth. Commercial diet chains are posting strong growth. Many untapped niches still exist. Medically supervised diet programs and franchises have seen growth slow, as commercial chains outperformed them since 2017.

This is a completely revised and updated analysis of the best-selling biennial study about the $72 billion U.S. weight loss market. This is the most comprehensive investigation of the U.S. weight loss market published by anyone worldwide.

Covered dollar value & growth rates of all major weight loss market segments (early 1980s to 2018, 2019 and 2023 forecasts), latest market trends and developments, status reports for: diet soft drinks, artificial sweeteners, health clubs, commercial diet center chains, multi-level marketing diet plans, OTC meal replacements & diet pills, medical programs (weight loss surgery, MDs, hospitals/clinic programs, Rx diet drugs, bariatricians, VLCD programs), low-cal frozen entrees, and the diet books & exercise DVDs market.

New for this edition:

2018 results, 2019 & 2023 Forecasts

Newly popular diets like Keto, intermittent fasting

Leading competitor management interviews

How the 2019 diet season is shaping up. 2018 market performance

The Millennials dilemma – why they are the future customers, how to reach them

Reasons for the strong growth of Weight Watchers and Medifast

Why MLM has gained as a distribution model

Why meal replacements are still booming, but not OTC diet pills

Outlook for medical weight loss programs of all types, why they’ve lost momentum

New Company Profiles: Profile by Sanford, Beach Body, Quick Weight Loss

Findings of the latest surveys by: U.S. Census Bureau, Nutrition Business Journal, U.S. News, CDC, more

Also included: Top competitors ranking, 30-year revenue analysis of the market through past recessions and fad diet cycles, comprehensive dieter demographics, weight loss center franchising, and extensive national/state commercial centers’ operating ratios. Rankings & revenues of top commercial chains, brand sales, and a Reference Directory.

Contains 38 in-depth updated competitor profiles for: Weight Watchers, Jenny Craig, NutriSystem, Medifast, Herbalife, Visalis, Isagenix, Slim-Fast, Atkins Nutritionals, HMR, Optifast, Lindora Clinics, Slimgenics, Ideal Protein, Profile by Sanford, Beach Body, Quick Weight Loss, Curves, 24 Hour Fitness, Metabolic Research, Smart For Life, Medi-Weightloss, Centers for Medical Weight Loss, Nuviva, JumptStart MD, Dr. G’s, and many more.

Key Topics Covered

Introduction

Scope

Methodology

Executive Overview

Discussion of diet market mega-trends: shift from diet products to services, medical programs lose ground, what’s wrong with commercial chains, importance of counselors, franchising pros & cons, consumer clean eating & high protein trend, performance in a recession,

Outlooks/results of interviews with 3 top diet companies

Outlook for new 2019 diet season, discussion of rise of MLM firms, DIY trends, company programs, competition from apps, advertising strategies

Summary of major market developments & trends of 2017-2018

$ size of market and its 12 segments, forecasted 2019-2023 growth rates for segments

Market Segment Outlooks for 2017-2018, 2019, 2023: commercial chains, diet soft drinks & artificial sweeteners, low-cal foods, meal replacements & appetite suppressants mkt., medical weight loss programs (hospitals & clinics, bariatric surgery, Rx diet drugs), diet books & DVDs market

Tables:

Historical market revenues $ size, by segment: 1989-2018

Revenues of top commercial chains: 2009-2018

Diet soft drink sales: 1989-2023 F

Revenues of health clubs industry: 1993-2023 F

No. of bariatric surgeries in the U.S. – 1992-2023 F

Value of meal replacements and OTC diet pills sales: 2005-2023 F

Highlights of ALL study chapters contained in the Overview

Dieter Demographics

Scope of the American obesity epidemic, number/percent obese or overweight, latest CDC data, obesity rates by state, recent dieter trends (shift to do-it-yourself methods during last recession), ranking of top diet programs by U.S.

News & World Report – 2019

Discussion: how many Americans diet, how often, why diets fail, methods used

Dieter actions don’t match intentions: survey results, the January diet surge

To healthy eating trends – predictions, top 10 diet types used by consumers

Typical dieter profile, by age, sex, income – number of diet attempts per year

Number of dieters by method used, no. of dieters by type plan (2016)

Dieter profiles by: BMI, budget, starting weight, preferred diet program location, type food desired, previous diet plans used, readiness, exercise plan desired, % needing psychological support, % with special foods needs (BestDietForMe.com – 2005-2012 data)

Analysis of current & historical dieting trends, 12-year shifts in dieting methods

The Millennials Dilemma: Definition and no. of Millennials, characteristics and suggestions for how diet companies can reach them (income levels, jobs, preferences)

Findings of Dieter Surveys/profiles by: Calorie Control Council, no. of U.S. dieters & low-cal food/beverage users, top dieting methods used, low-cal food/beverage usage by kind, diet attempts, Table: State/regional obesity statistics: % of population, 1991-2017

American Exercise Trends, Health Clubs & Weight Loss Programs

Status Report of U.S. Health Clubs Industry

No. of facilities, type clubs, number of club members, recent trends, Industry receipts: 1993-2023 F, characteristics of club members, drop-out rates, members by type club, estd. share of clubs with diet programs. (IHRSA)

ASCM’s top fitness trends for 2019

15 top participant sports -(NSGA), % chg. In participation

Most popular women’s sports: types of exercise equipment, home exercise trends

How women keep fit, most popular types of exercise equip. used, general trends in exercise, home exercise and gyms.

Health clubs’ involvement with weight loss, % with programs, using clubs as weight loss method, samples/costs of typical diet programs offered by health clubs (Think Light plan).

Reasons why health clubs’ weight loss programs fail, programs vary greatly in price & content-consultants’ analysis, private label wt. loss programs (A. Rothafel)

Company Profiles: Curves, 24 Hour Fitness

Commercial Weight Loss Chains

Summary & nature of competitors, discussion of all major developments since 2017 (no. of centers, avg. cost of major commercial plans vs. medical and self-help plans, 2017-2018 segment performance, 2019 outlook, estd. revenues of leaders

In-depth discussion of leaders’ strategies, move to wellness, Weight Watchers turnaround, success of Medifast, Profile by Sanford franchise Jenny Craig/Curves status, why medical programs lost ground, factors affecting 2019 diet season, program customization, latest hot diets

Positive/negative factors affecting growth from 2019-2023

Tables:

Avg. cost of popular diet programs (Forbes)

No. of center locations, by company: 2008-2018

Revenues of the leading commercial chains: 2015-2018

Historical table of segment revenues/growth from 1989-2023 F

Census Bureau snapshot of the industry: 1997, 2002, 2007, 2012, key ratios, stats

Industry Structure & Key Ratios

2012, 2007, 2002 industry snapshots for commercial diet centers: no. of establishments, legal form of firms, top 50 firms mkt. share, ratios by firm’s receipts, top states

Sample income statement for a typical commercial center: (expenses by type, profits)

Avg. revenues per co.-owned/franchised center for Jenny Craig & LA Weight Loss

Avg. costs to acquire new customers

What commercial centers have in common, expansion of 1980s/contraction of 1990s 1982-88 diet franchise avg. revenues per unit, no. of centers/sites operated by top chains.

Franchising: status of, use as growth strategy, investment costs, profiles of Wt. Watchers, Jenny Craig franchises, why franchising may be less viable today. Census Bureau Operating Ratios: 2012, 2007, 2002 (Commercial diet centers/services) (no. of estabs., firms, receipts, receipts per estab., payroll as % sales, etc.)

Tables:

Industry snapshot: no. of estabs., receipts, avg. per estab. & employee, payroll as % sales, etc.

Employee sales/payroll productivity

Establishments, by legal form (corporations, partnerships, sole proprietors)

Market share for largest 4, 8, 20, 50 firms

Ratios, by single vs. multi-unit firms

Ratios, by receipts size of firms & establishments

No. of diet centers, by state & region, avg. receipts per estab. By state

No. of diet centers, by state, ranked by sales and avg. receipts per establishment

2016 no. of estabs. payroll, estd. receipts, by state, ranked (County Business Patterns)

Other Tables:

No. of U.S. weight control services (1991-2015)

Number of commercial centers (2007, 2008, 2010, 2012, 2014, 2016, 2018- top chains) Company profiles: in-depth company history, current status, how programs work, costs, franchise systems, 2009-2016 & historical revenues, new programs, strategies, address/website):

Weight Watchers International

Jenny Craig

NutriSystem

Medifast

Metabolic Research Centers

Profile by Sanford

Slimgenics

Quick Weight Loss Centers

The Diet Soft Drinks & Artificial Sweeteners, Diet Food Markets

The Diet Soft Drinks Market

Status Report 2018, why the slump continues, diet soft drinks as % total soft drinks, mkt. nature and historical growth, forecasts, demographics of consumers, diet’s share of all carbonated soft drinks (Beverage Industry, Beverage Digest),

Total soft drink retail $ sales, diet share of gallons/retail sales: 1989-2018, 2018-2023 forecast

1989-2023 F diet soft drink $ sales

Table: Demographics of diet soft drink consumers, historical nature of the market.

The Artificial Sweeteners Market

Status Report of the mkt., new high intensity sweeteners emerging, Stevia, Sucralose, Splenda, consumer trend to avoid artificial ingredients, data from Calorie Control Council regarding use by consumers

Sweeteners by end use (% for soft drinks vs. tabletop sweeteners mkt.)

Description of major types (Aspartame, Neotame, Saccharin, Sucralose, Stevia, Acesulfame)

Market size & growth, historical sales 1991-2018 performance, 2023 forecasts

Low-cal Frozen Diet Entrees & Low-cal Foods Market

Mkt. Status Report, definition of diet foods, discussion of dinner entrees, the major brands, Consumers shift to fresh foods away from frozen, actions by food industry to spur sales

Actions taken by producers to revitalize sales, packaging, new formulations, etc.

Mkt. size estimates for 1994 to 2023 F

Outlook and sales estim. For 2013-2018 $ volume for Lean Cuisine, Smart Ones, Healthy Choice

Low-cal diet dinner entrees mkt. size: Healthy Choice, Wt. Watchers, Lean Cuisine retail sales, brands outlooks in 2015-2018

Company Profile: Atkins Nutritionals

Retail Meal Replacements & Appetite Suppressants Market

Story continues

Definition/nature of meal replacements vs. over-the-counter (OTC) diet pills, ingredients being used today, new herbal products: coffee bean extract, HCG drops

History/nature of mkt.- cyclical shifts from mid-1980s

User demographics: no. and % of dieters using diet pills and meal replacements (Consumer Reports, Bestdietforme.com surveys: 2005-2012 data).

2018 Status Report of the market: estd. channel sales (diet pills, meal replace.), findings of Nutrition Business Journal (NBJ) research, top meal replacements brands sales

Why growth outlook is strong for meal replacements, preferred by MDs, MLMs, commercial chains, why OTC diet pills mkt. still struggles for legitimacy

Regulatory actions, FTC fines marketers, effect/warning on touting miracle products for weight loss, Hyroxycut’s fall

Discussion of traditional/nontraditional distribution channels

Mkt. size/growth: true size of the mkt.

why estimates differ widely

NBJ estimates of diet pill & meal replacements $ and % sales, by distribution channels, discussion of multilevel firms (Advocare, Shaklee, Herbalife, Quixtar, Nu-Skin, EAS, Atkins)

Estimates of growth for diet pills & meal replacements 2018-2023, demand factors.

Discussion of the acquisition of Slim-Fast by Glanbia.

Tables:

Estimates of OTC diet pills, meal replacements, combined sales 1981-2023 F

Discussion of 2017-2018 market performance, 2019 outlook, 2023 forecasts

Top OTC diet pill brand sales in 2007, 2010, 2011, 2013, 2015

Top MLM companies’ sales of meal replacements: 2017. Company profiles: Slim-Fast, Herbalife, Visalis Life Sciences , Isagenix, Advocare (revenues, strategies, product lines, marketing, effect on other MLMs rapid rise and fall of Visalis)

Medically-Supervised Weight Loss Programs

Hospital & Clinic Chains Weight Loss Programs

Types of plans offered (low-cost, moderate-cost plans, estd. no. of hospitals providing each, typical cost), Medicare new coverage

Interviews with management at HMR, Medi-Weightloss companies.

Physician-based diet programs: diet drugs/other methods used, consumer attitudes, limitations, estd. no. MDs with a weight loss program – independents vs. affiliated with chains, meds used, typical cost of MD programs

How Obamacare has provided a game-changing opportunity for MDs to add weight loss & counseling services via PAs, RDs, Nurses, why they haven’t embraced it yet

Profiles of a hospital-based weight loss program: Johns Hopkins

Major Medical Chains: Company Profiles Lindora Clinics, Centers for Medical Weight Loss, Smart for Life, Medi-Weightloss Clinics, Medical Weight Loss of Michigan, new chains: Nuviva, Dr. G’s, Let’s Lose, JumpstartMD, Ideal Protein (in-depth descriptions, plan costs, estimated revenues, no. of centers, franchising growth strategies). Tables: Avg. revenues per site, avg. plan cost to patient, avg. income statement, start-up Costs for top 8 medical weight loss chains/franchises/licensors.

Bariatrician Programs

Status report of profession, ASBP survey results (MDs by: age, income, size practice), how they’re trained, number practicing, certification by ASBP, use of diet drugs, treatment methods used, plan effectiveness/cost, business is up due to more surgeries, less surgeries – opinions of industry consultant.

The Weight Loss (bariatric) Surgery Market

Discussion of sleeve, gastric bypass, lapband procedures, why demand grew strongly to 2007, status report & intrview, 2018 estimated surgeries, 2019 & 2023 forecasts, costs per surgery by type payor, pros/cons, who qualifies, effect of Obamacare on coverage by 25 state exchanges

Surgery utilization and outcomes, mean cost per surgery

Major insurers’ coverage today, status report, Medicare position, role of liaison firms (The Wish Centers, Barix Clinics, Liv-Lite, Journey Lite

addresses), avg. cost of surgery.

Types of surgery: Roux-en-Y, lap banding, mini-gastric bypass, sleeve, consumer pros/cons

Table: No. of bariatric surgeries performed: 1992-2018

Table: $ value of the market: 1992-2023 F, outlook under Obamacare

Associations: ASBS, Obesity Action Coalition, increased lobbying efforts.

VLCD/LCD Fasting Supplement Programs

Status report of low-calorie modified fasting programs in 2018, effect of bariatric surgeries, outlooks by mgmt. at HMR, strong demand from hospitals for tunkey programs characterizing the mkt. (price, programs, no. of sites, increased direct-to-customer sales)

Historical nature of market development from 1970s-1990s, enrollments, drop-out/completion rates, problem on insurance coverage, market indicators, positive/negative trends/factors

Table: Estimates of VLCD enrollments for 1995-2018 (new vs. repeat patients, fasting vs. maintenance), $ value of mkt. for 1984-2023 F

Company Profiles: Detailed descriptions of companies/plans, program revenues: Health Management Resources, Optifast (Nestle)

Table: VLCD enrollments, $ mkt. value: estimates: 2007-2018.

The Diet Drugs Market

Discussion of viewing obesity as a disease, major obesity medications used today, FDA position, role of MDs, commercial chains’ involvement with diet drugs, why it’s tougher than thought to develop anti-obesity drugs that are effective and with minimal side effects.

Status Report: Contrave, Qsymia & Belviq sales, FDA rejections of: Acomplia, Taranabant, other Rx diet drugs

New obesity drugs in development: Saxenda, Beloranib, Mirabegron – timeline for approval

Existing drugs used (Xenical, Phentermine) descriptions

Tables

Prescriptions written and $ sales for: Meridia, Xenical, Phentermine, 12 other anti-obesity drugs (2003-2016), historical sales 1995-2000

2019 and 2023 outlooks for prescription diet drugs, effect of new drugs on mkt. Size, discussion of this market’s potential vs. drawbacks, overcoming MD and consumer Attitudes, side effects, effectiveness. Moderate weight loss not enough for most dieters.

The Diet Books & Exercise DVDs Market

Diet books – nature of the mkt., new 2017 & 2018 diet books, buyer demographics, what makes Bestsellers, book buyer demographics, recent titles

Exercise DVDs & streaming services mkt., summary, top names in the field, categories, top distributors, mkt. size

Estimates of combined diet books/exercise DVDs mkts. For 2017, 2018 Outlooks and rationale, popularity as DIY method.

Table: $ sales of diet books & exercise DVDs: 1989-2023 F

Company Profile: Beach Body

Companies Mentioned

24 Hour Fitness

Advocare

Atkins Nutritionals

Barix Clincis

Beach Body

BestDietForMe.com

Centers for Medical Weight Loss

Curves

Dr. G’s

EAS

Herbalife

Ideal Protein

Isagenix

Jenny Craig

Journey Lite

JumpstartMD

Let’s Lose

Lindora Clinics

Liv-Lite

Medi-Weightloss Clinics

Medical Weight Loss of Michigan

Medifast

Metabolic Research Centers

Nestle

Nu-skin

NutriSystem

Nuviva

Profile by Sanford

Quick Weight Loss Centers

Quixtar

Shaklee

Slim-Fast

Slimgenics

Smart for Life

The Wish Centers

Vislais Life Sciences

Weight Watchers International

For more information about this report visit https://www.researchandmarkets.com/r/rmddj2

Research and Markets also offers Custom Research services providing focused, comprehensive and tailored research.

Media Contact:

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The $72B United States Weight Loss & Diet Control Market, 2019

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The $72B United States Weight Loss & Diet Control Market, 2019

DUBLIN, July 19, 2019 /PRNewswire/ — The “The $72B United States Weight Loss & Diet Control Market, 2019″ report has been added to ResearchAndMarkets.com’s offering.

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The U.S. weight loss market is now worth a record $72 billion, but the number of dieters has fallen, due to the growth of the size acceptance and body positivity movement.

Do-it-yourself plans still abound as consumers use free diet & fitness apps. Consumers are shunning processed foods and artificial ingredients, but frozen food makers have adjusted and sales are showing signs of growth. Commercial diet chains are posting strong growth. Many untapped niches still exist. Medically supervised diet programs and franchises have seen growth slow, as commercial chains outperformed them since 2017.

This is a completely revised and updated analysis of the best-selling biennial study about the $72 billion U.S. weight loss market. This is the most comprehensive investigation of the U.S. weight loss market published by anyone worldwide.

Covered dollar value & growth rates of all major weight loss market segments (early 1980s to 2018, 2019 and 2023 forecasts), latest market trends and developments, status reports for: diet soft drinks, artificial sweeteners, health clubs, commercial diet center chains, multi-level marketing diet plans, OTC meal replacements & diet pills, medical programs (weight loss surgery, MDs, hospitals/clinic programs, Rx diet drugs, bariatricians, VLCD programs), low-cal frozen entrees, and the diet books & exercise DVDs market.

New for this edition:

2018 results, 2019 & 2023 Forecasts

Newly popular diets like Keto, intermittent fasting

Leading competitor management interviews

How the 2019 diet season is shaping up. 2018 market performance

The Millennials dilemma – why they are the future customers, how to reach them

Reasons for the strong growth of Weight Watchers and Medifast

Why MLM has gained as a distribution model

Why meal replacements are still booming, but not OTC diet pills

Outlook for medical weight loss programs of all types, why they’ve lost momentum

New Company Profiles: Profile by Sanford, Beach Body, Quick Weight Loss

Findings of the latest surveys by: U.S. Census Bureau, Nutrition Business Journal, U.S. News, CDC, more

Also included: Top competitors ranking, 30-year revenue analysis of the market through past recessions and fad diet cycles, comprehensive dieter demographics, weight loss center franchising, and extensive national/state commercial centers’ operating ratios. Rankings & revenues of top commercial chains, brand sales, and a Reference Directory.

Contains 38 in-depth updated competitor profiles for: Weight Watchers, Jenny Craig, NutriSystem, Medifast, Herbalife, Visalis, Isagenix, Slim-Fast, Atkins Nutritionals, HMR, Optifast, Lindora Clinics, Slimgenics, Ideal Protein, Profile by Sanford, Beach Body, Quick Weight Loss, Curves, 24 Hour Fitness, Metabolic Research, Smart For Life, Medi-Weightloss, Centers for Medical Weight Loss, Nuviva, JumptStart MD, Dr. G’s, and many more.

Key Topics Covered

Introduction

Scope

Methodology

Executive Overview

Discussion of diet market mega-trends: shift from diet products to services, medical programs lose ground, what’s wrong with commercial chains, importance of counselors, franchising pros & cons, consumer clean eating & high protein trend, performance in a recession,

Outlooks/results of interviews with 3 top diet companies

Outlook for new 2019 diet season, discussion of rise of MLM firms, DIY trends, company programs, competition from apps, advertising strategies

Summary of major market developments & trends of 2017-2018

$ size of market and its 12 segments, forecasted 2019-2023 growth rates for segments

Market Segment Outlooks for 2017-2018, 2019, 2023: commercial chains, diet soft drinks & artificial sweeteners, low-cal foods, meal replacements & appetite suppressants mkt., medical weight loss programs (hospitals & clinics, bariatric surgery, Rx diet drugs), diet books & DVDs market

Tables:

Historical market revenues $ size, by segment: 1989-2018

Revenues of top commercial chains: 2009-2018

Diet soft drink sales: 1989-2023 F

Revenues of health clubs industry: 1993-2023 F

No. of bariatric surgeries in the U.S. – 1992-2023 F

Value of meal replacements and OTC diet pills sales: 2005-2023 F

Highlights of ALL study chapters contained in the Overview

Dieter Demographics

Scope of the American obesity epidemic, number/percent obese or overweight, latest CDC data, obesity rates by state, recent dieter trends (shift to do-it-yourself methods during last recession), ranking of top diet programs by U.S.

News & World Report – 2019

Discussion: how many Americans diet, how often, why diets fail, methods used

Dieter actions don’t match intentions: survey results, the January diet surge

To healthy eating trends – predictions, top 10 diet types used by consumers

Typical dieter profile, by age, sex, income – number of diet attempts per year

Number of dieters by method used, no. of dieters by type plan (2016)

Dieter profiles by: BMI, budget, starting weight, preferred diet program location, type food desired, previous diet plans used, readiness, exercise plan desired, % needing psychological support, % with special foods needs (BestDietForMe.com – 2005-2012 data)

Analysis of current & historical dieting trends, 12-year shifts in dieting methods

The Millennials Dilemma: Definition and no. of Millennials, characteristics and suggestions for how diet companies can reach them (income levels, jobs, preferences)

Findings of Dieter Surveys/profiles by: Calorie Control Council, no. of U.S. dieters & low-cal food/beverage users, top dieting methods used, low-cal food/beverage usage by kind, diet attempts, Table: State/regional obesity statistics: % of population, 1991-2017

American Exercise Trends, Health Clubs & Weight Loss Programs

Status Report of U.S. Health Clubs Industry

No. of facilities, type clubs, number of club members, recent trends, Industry receipts: 1993-2023 F, characteristics of club members, drop-out rates, members by type club, estd. share of clubs with diet programs. (IHRSA)

ASCM’s top fitness trends for 2019

15 top participant sports -(NSGA), % chg. In participation

Most popular women’s sports: types of exercise equipment, home exercise trends

How women keep fit, most popular types of exercise equip. used, general trends in exercise, home exercise and gyms.

Health clubs’ involvement with weight loss, % with programs, using clubs as weight loss method, samples/costs of typical diet programs offered by health clubs (Think Light plan).

Reasons why health clubs’ weight loss programs fail, programs vary greatly in price & content-consultants’ analysis, private label wt. loss programs (A. Rothafel)

Company Profiles: Curves, 24 Hour Fitness

Commercial Weight Loss Chains

Summary & nature of competitors, discussion of all major developments since 2017 (no. of centers, avg. cost of major commercial plans vs. medical and self-help plans, 2017-2018 segment performance, 2019 outlook, estd. revenues of leaders

In-depth discussion of leaders’ strategies, move to wellness, Weight Watchers turnaround, success of Medifast, Profile by Sanford franchise Jenny Craig/Curves status, why medical programs lost ground, factors affecting 2019 diet season, program customization, latest hot diets

Positive/negative factors affecting growth from 2019-2023

Tables:

Avg. cost of popular diet programs (Forbes)

No. of center locations, by company: 2008-2018

Revenues of the leading commercial chains: 2015-2018

Historical table of segment revenues/growth from 1989-2023 F

Census Bureau snapshot of the industry: 1997, 2002, 2007, 2012, key ratios, stats

Industry Structure & Key Ratios

2012, 2007, 2002 industry snapshots for commercial diet centers: no. of establishments, legal form of firms, top 50 firms mkt. share, ratios by firm’s receipts, top states

Sample income statement for a typical commercial center: (expenses by type, profits)

Avg. revenues per co.-owned/franchised center for Jenny Craig & LA Weight Loss

Avg. costs to acquire new customers

What commercial centers have in common, expansion of 1980s/contraction of 1990s 1982-88 diet franchise avg. revenues per unit, no. of centers/sites operated by top chains.

Franchising: status of, use as growth strategy, investment costs, profiles of Wt. Watchers, Jenny Craig franchises, why franchising may be less viable today. Census Bureau Operating Ratios: 2012, 2007, 2002 (Commercial diet centers/services) (no. of estabs., firms, receipts, receipts per estab., payroll as % sales, etc.)

Tables:

Industry snapshot: no. of estabs., receipts, avg. per estab. & employee, payroll as % sales, etc.

Employee sales/payroll productivity

Establishments, by legal form (corporations, partnerships, sole proprietors)

Market share for largest 4, 8, 20, 50 firms

Ratios, by single vs. multi-unit firms

Ratios, by receipts size of firms & establishments

No. of diet centers, by state & region, avg. receipts per estab. By state

No. of diet centers, by state, ranked by sales and avg. receipts per establishment

2016 no. of estabs. payroll, estd. receipts, by state, ranked (County Business Patterns)

Other Tables:

No. of U.S. weight control services (1991-2015)

Number of commercial centers (2007, 2008, 2010, 2012, 2014, 2016, 2018- top chains) Company profiles: in-depth company history, current status, how programs work, costs, franchise systems, 2009-2016 & historical revenues, new programs, strategies, address/website):

Weight Watchers International

Jenny Craig

NutriSystem

Medifast

Metabolic Research Centers

Profile by Sanford

Slimgenics

Quick Weight Loss Centers

The Diet Soft Drinks & Artificial Sweeteners, Diet Food Markets

The Diet Soft Drinks Market

Status Report 2018, why the slump continues, diet soft drinks as % total soft drinks, mkt. nature and historical growth, forecasts, demographics of consumers, diet’s share of all carbonated soft drinks (Beverage Industry, Beverage Digest),

Total soft drink retail $ sales, diet share of gallons/retail sales: 1989-2018, 2018-2023 forecast

1989-2023 F diet soft drink $ sales

Table: Demographics of diet soft drink consumers, historical nature of the market.

The Artificial Sweeteners Market

Status Report of the mkt., new high intensity sweeteners emerging, Stevia, Sucralose, Splenda, consumer trend to avoid artificial ingredients, data from Calorie Control Council regarding use by consumers

Sweeteners by end use (% for soft drinks vs. tabletop sweeteners mkt.)

Description of major types (Aspartame, Neotame, Saccharin, Sucralose, Stevia, Acesulfame)

Market size & growth, historical sales 1991-2018 performance, 2023 forecasts

Low-cal Frozen Diet Entrees & Low-cal Foods Market

Mkt. Status Report, definition of diet foods, discussion of dinner entrees, the major brands, Consumers shift to fresh foods away from frozen, actions by food industry to spur sales

Actions taken by producers to revitalize sales, packaging, new formulations, etc.

Mkt. size estimates for 1994 to 2023 F

Outlook and sales estim. For 2013-2018 $ volume for Lean Cuisine, Smart Ones, Healthy Choice

Low-cal diet dinner entrees mkt. size: Healthy Choice, Wt. Watchers, Lean Cuisine retail sales, brands outlooks in 2015-2018

Company Profile: Atkins Nutritionals

Retail Meal Replacements & Appetite Suppressants Market

Story continues

Definition/nature of meal replacements vs. over-the-counter (OTC) diet pills, ingredients being used today, new herbal products: coffee bean extract, HCG drops

History/nature of mkt.- cyclical shifts from mid-1980s

User demographics: no. and % of dieters using diet pills and meal replacements (Consumer Reports, Bestdietforme.com surveys: 2005-2012 data).

2018 Status Report of the market: estd. channel sales (diet pills, meal replace.), findings of Nutrition Business Journal (NBJ) research, top meal replacements brands sales

Why growth outlook is strong for meal replacements, preferred by MDs, MLMs, commercial chains, why OTC diet pills mkt. still struggles for legitimacy

Regulatory actions, FTC fines marketers, effect/warning on touting miracle products for weight loss, Hyroxycut’s fall

Discussion of traditional/nontraditional distribution channels

Mkt. size/growth: true size of the mkt.

why estimates differ widely

NBJ estimates of diet pill & meal replacements $ and % sales, by distribution channels, discussion of multilevel firms (Advocare, Shaklee, Herbalife, Quixtar, Nu-Skin, EAS, Atkins)

Estimates of growth for diet pills & meal replacements 2018-2023, demand factors.

Discussion of the acquisition of Slim-Fast by Glanbia.

Tables:

Estimates of OTC diet pills, meal replacements, combined sales 1981-2023 F

Discussion of 2017-2018 market performance, 2019 outlook, 2023 forecasts

Top OTC diet pill brand sales in 2007, 2010, 2011, 2013, 2015

Top MLM companies’ sales of meal replacements: 2017. Company profiles: Slim-Fast, Herbalife, Visalis Life Sciences , Isagenix, Advocare (revenues, strategies, product lines, marketing, effect on other MLMs rapid rise and fall of Visalis)

Medically-Supervised Weight Loss Programs

Hospital & Clinic Chains Weight Loss Programs

Types of plans offered (low-cost, moderate-cost plans, estd. no. of hospitals providing each, typical cost), Medicare new coverage

Interviews with management at HMR, Medi-Weightloss companies.

Physician-based diet programs: diet drugs/other methods used, consumer attitudes, limitations, estd. no. MDs with a weight loss program – independents vs. affiliated with chains, meds used, typical cost of MD programs

How Obamacare has provided a game-changing opportunity for MDs to add weight loss & counseling services via PAs, RDs, Nurses, why they haven’t embraced it yet

Profiles of a hospital-based weight loss program: Johns Hopkins

Major Medical Chains: Company Profiles Lindora Clinics, Centers for Medical Weight Loss, Smart for Life, Medi-Weightloss Clinics, Medical Weight Loss of Michigan, new chains: Nuviva, Dr. G’s, Let’s Lose, JumpstartMD, Ideal Protein (in-depth descriptions, plan costs, estimated revenues, no. of centers, franchising growth strategies). Tables: Avg. revenues per site, avg. plan cost to patient, avg. income statement, start-up Costs for top 8 medical weight loss chains/franchises/licensors.

Bariatrician Programs

Status report of profession, ASBP survey results (MDs by: age, income, size practice), how they’re trained, number practicing, certification by ASBP, use of diet drugs, treatment methods used, plan effectiveness/cost, business is up due to more surgeries, less surgeries – opinions of industry consultant.

The Weight Loss (bariatric) Surgery Market

Discussion of sleeve, gastric bypass, lapband procedures, why demand grew strongly to 2007, status report & intrview, 2018 estimated surgeries, 2019 & 2023 forecasts, costs per surgery by type payor, pros/cons, who qualifies, effect of Obamacare on coverage by 25 state exchanges

Surgery utilization and outcomes, mean cost per surgery

Major insurers’ coverage today, status report, Medicare position, role of liaison firms (The Wish Centers, Barix Clinics, Liv-Lite, Journey Lite

addresses), avg. cost of surgery.

Types of surgery: Roux-en-Y, lap banding, mini-gastric bypass, sleeve, consumer pros/cons

Table: No. of bariatric surgeries performed: 1992-2018

Table: $ value of the market: 1992-2023 F, outlook under Obamacare

Associations: ASBS, Obesity Action Coalition, increased lobbying efforts.

VLCD/LCD Fasting Supplement Programs

Status report of low-calorie modified fasting programs in 2018, effect of bariatric surgeries, outlooks by mgmt. at HMR, strong demand from hospitals for tunkey programs characterizing the mkt. (price, programs, no. of sites, increased direct-to-customer sales)

Historical nature of market development from 1970s-1990s, enrollments, drop-out/completion rates, problem on insurance coverage, market indicators, positive/negative trends/factors

Table: Estimates of VLCD enrollments for 1995-2018 (new vs. repeat patients, fasting vs. maintenance), $ value of mkt. for 1984-2023 F

Company Profiles: Detailed descriptions of companies/plans, program revenues: Health Management Resources, Optifast (Nestle)

Table: VLCD enrollments, $ mkt. value: estimates: 2007-2018.

The Diet Drugs Market

Discussion of viewing obesity as a disease, major obesity medications used today, FDA position, role of MDs, commercial chains’ involvement with diet drugs, why it’s tougher than thought to develop anti-obesity drugs that are effective and with minimal side effects.

Status Report: Contrave, Qsymia & Belviq sales, FDA rejections of: Acomplia, Taranabant, other Rx diet drugs

New obesity drugs in development: Saxenda, Beloranib, Mirabegron – timeline for approval

Existing drugs used (Xenical, Phentermine) descriptions

Tables

Prescriptions written and $ sales for: Meridia, Xenical, Phentermine, 12 other anti-obesity drugs (2003-2016), historical sales 1995-2000

2019 and 2023 outlooks for prescription diet drugs, effect of new drugs on mkt. Size, discussion of this market’s potential vs. drawbacks, overcoming MD and consumer Attitudes, side effects, effectiveness. Moderate weight loss not enough for most dieters.

The Diet Books & Exercise DVDs Market

Diet books – nature of the mkt., new 2017 & 2018 diet books, buyer demographics, what makes Bestsellers, book buyer demographics, recent titles

Exercise DVDs & streaming services mkt., summary, top names in the field, categories, top distributors, mkt. size

Estimates of combined diet books/exercise DVDs mkts. For 2017, 2018 Outlooks and rationale, popularity as DIY method.

Table: $ sales of diet books & exercise DVDs: 1989-2023 F

Company Profile: Beach Body

Companies Mentioned

24 Hour Fitness

Advocare

Atkins Nutritionals

Barix Clincis

Beach Body

BestDietForMe.com

Centers for Medical Weight Loss

Curves

Dr. G’s

EAS

Herbalife

Ideal Protein

Isagenix

Jenny Craig

Journey Lite

JumpstartMD

Let’s Lose

Lindora Clinics

Liv-Lite

Medi-Weightloss Clinics

Medical Weight Loss of Michigan

Medifast

Metabolic Research Centers

Nestle

Nu-skin

NutriSystem

Nuviva

Profile by Sanford

Quick Weight Loss Centers

Quixtar

Shaklee

Slim-Fast

Slimgenics

Smart for Life

The Wish Centers

Vislais Life Sciences

Weight Watchers International

For more information about this report visit https://www.researchandmarkets.com/r/rmddj2

Research and Markets also offers Custom Research services providing focused, comprehensive and tailored research.

Media Contact:

Research and Markets Laura Wood, Senior Manager press@researchandmarkets.com   

For E.S.T Office Hours Call +1-917-300-0470 For U.S./CAN Toll Free Call +1-800-526-8630 For GMT Office Hours Call +353-1-416-8900

U.S. Fax: 646-607-1907 Fax (outside U.S.): +353-1-481-1716

View original content:http://www.prnewswire.com/news-releases/the-72b-united-states-weight-loss–diet-control-market-2019—featuring-growth-rates-of-all-major-weight-loss-market-segments-early-1980s-to-2018-2019-and-2023-forecasts-300888051.html

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Formulation and Evaluation of Bilayer Tablets of Sustained Release Microspheres of Anti Diabetic Drugs

INTRODUCTION The oral route is the most commonly used route for drug administration. Although the different route of administration is used for the delivery of drugs, oral route remain the preferred mode. The oral route is one of the most popular routes of drug delivery due to its ease of administration, patient compliance, least sterility constraints and flexible design of dosage form1. Introduction to Sustained Release Formulation2, 3, 4 For decades an acute or chronic illness is being clinically treated through the delivery of drugs to the patients in form of some pharmaceutical dosage forms like tablets, capsules, liquids, creams, pills, aerosols, injectable, and suppositories. However, these conventional dosage forms have some drawbacks. When conventional immediate release dosage forms are taken on schedule and more than once daily, there are sequential therapeutically blood peaks and valley associated with taking each dose. It should be emphasized that the plasma level of a drug should be maintained within the safe margin and effective range. For this proper and calculated doses of the drug need to be given at different time interval by conventional dosage form (Fig. 1.1). To achieve and maintain the concentration of administered drug within a therapeutically effective range, it is often necessary to take drug dosage several times and these results in a fluctuating drug level in plasma.

Figure 1: Drug levels in the blood with I.V. administration and Controlled release deliver Mainly greater attention has been focused on the development of controlled or sustained release drug delivery systems with concomitant recognition of the therapeutic advantages of controlled drug delivery. Controlled drug delivery systems have been introduced to overwhelm the drawback of fluctuating drug levels associated with conventional dosage forms.   Terminologies5 Extended-release dosage form Delayed release dosage form Modified release dosage form Microspheres6 The term Microsphere is defined as a spherical particle with size varying with diameters in the micrometer range (typically 1μm to 1000μm (1mm), containing a core substance. The microspheres are characteristically free flowing powders consisting of proteins or synthetic polymers, which are biodegradable in nature, and ideally having a particle size less than 200 micrometers. Microsphere has been extensively studied for use as drug delivery systems, where they have been shown to protect sensitive macromolecules from enzymatic and acid degradation, and allow controlled release and tissue targeting of the formulated drug. Bilayer Tablet7 Dual release tablet is a unit compressed tablet dosage form intended for oral application. It contains two layers in which one layer having conventional or immediate release part of single or multiple actives; another layer is sustained or controlled release part of single or multiple actives‖. They are also called as Bilayer tablet, multi-layer matrix tablet. MATERIALS AND METHODS The following materials of Pharma grade or the best possible Laboratory Reagent (LR) were used as supplied by the manufacturer. MHCl, PHCl were obtained from Wanbury Ltd., Mumbai. HPMC 15K was obtained from Shreeji chemicals, Mumbai. Acetone, Methanol, Ethanol, Light liquid paraffin oil, Span 80 were obtained from SDFCL Mumbai. Petroleum Ether, Talc, Hydrochloric acid, MCC, Lactose were obtained from Pharma Link Hyderabad. Potassium Dihydrogen Phosphate, Sodium Hydroxide Pellets, Calcium Stearate were obtained from Amishi Drugs and Chemicals Ltd, Ahmedabad. RESULTS AND DISCUSSION Preformulation Studies Preformulation testing is the first step in the rational development of dosage forms of a drug substance. It can be defined as an investigation of physical and chemical properties of a drug substance alone and when combined with excipients. The overall objective of preformulation testing is to generate information useful to the formulator in developing stable and bioavailable dosage forms, which can be mass-produced. Identification of MHCl and PHCl Identification of MHCl and PHCl was carried out by FTIR spectrophotometry. pH Determination pH of MHCl and PHCl was determined using potentiometer by digital pH meter. Melting Point Determination The melting point of MHCl and PHCl was determined by taking a small amount of drug in a capillary tube closed at one end. The capillary tube was placed in a melting point apparatus and the temperature at which drug melts was recorded. This was performed thrice and an average value was noted. Solubility Studies An excess amount of the drug was taken and dissolved in a measured volume of distilled water in a glass vial to get a saturated solution. The solution was sonicated and kept at room temp for the attainment of equilibrium. The concentration of MHCl and PHCl of in the filtrate was determined spectrophotometrically by measuring at 233 nm and 269 nm respectively. Drug Excipient Compatibility Testing FTIR spectroscopy was performed on Fourier transformed infrared spectrophotometer (IR-Affinity-1, Shimadzu, Japan). The pellets of drug and potassium bromide were prepared by compressing the powders at 20 psi for 10 min on KBr-press and the spectra were scanned in the wave number range of 4000- 400 cm-1. FTIR study was carried out on MHCl, PHCl, Polymer, physical mixture of PHCl and polymer and MHCl and polymer. Preparation of Standard Calibration Curves Preparation of Standard Calibration Curves of MHCl Metformin calibration curve in water at 233 nm 100 mg of MHCl was dissolved in small amount of water and volume was made up to 100ml using the same. From the stock solution, serial dilutions were done to obtain solutions in the concentration ranging from 10 to 100 mcg/ml. The absorbance of the solution was measured at 233 nm using a UV-visible spectrophotometer. A graph of concentration v/s absorbance was plotted. Similarly, a standard calibration curve of MHCl was prepared in Phosphate buffer pH6.8 and Hydrochloric acid buffer pH 2 by using above said method. Preparation of Standard Calibration Curve of PHCl at 269nm PHCl calibration curve in pH 2 buffer at 269 nm 50 mg of PHCl was dissolved in small amount of water and volume was made up to 100ml using the same. From the stock solution, serial dilutions were done to obtain solutions in the conc. ranging from 10 to 50 mcg/ml. The absorbance of the solution was measured at 269 nm using a UV-visible spectrophotometer. A graph of concentration v/s absorbance was plotted. Similarly, a standard calibration curve of PHCl was prepared in Phosphate buffer pH6.8 and Hydrochloric acid buffer pH 2 by using above said method. Selection of Directly Compressible Material for Preparation of Bilayered Tablets of MHCl Microspheres and PHCl2, 8, 9 The bilayered tablets were prepared by direct compression method.  Blends for both layers were prepared separately by weighing and mixing a required quantity of ingredients in geometric proportions for 10 mins. Two different directly compressible materials viz. microcrystalline cellulose and dibasic calcium phosphate were used to compress microspheres to prepare bilayered tablets. The MHCl layer was pre-compressed by hydraulic pellet press by compression force 5 kg/cm2. Then the PHCl layer was added and the tablet was finally compressed with compression force 25 kg/cm2 and dwell time 15 secs. The formula for the composition of MHCl layer and PHCl layer is given in Table 1. Table 1: Composition of bilayer tablet of MHCl microspheres and PHCl Ingredient quantity in mg/tablet MP1 MP2 M1 P1 M2 P2 MHCl PHCl 130 25 130 25 HPMC 15k HPMC 15k 25 60 25 60 MCC MCC 100 - - 40 DCP DCP - 40 100 - Lactose Lactose 35.5 65 35.5 65 Ca Stearate Ca Stearate 3.5 6 3.5 6 Talc Talc 10 4 10 4 Avg. wt. bilayer tablet in mg/tablet 500 500 Evaluation of Bilayered Tablets of MHCL Microspheres and PHCL 8 Weight Variation Test

20 tablets were weighed individually, the average weight of tablets was calculated and their upper and lower limits were calculated and Percentage weight variation was calculated using the following formula 1.  Drug Content

The drug content is determined spectrophotometrically. The tablets were weighed and powdered. An accurately weighed quantity of the sample was taken and extracted in Hydrochloric acid buffer pH 2 and the content was determined using a UV spectrophotometer at 233nm and 269nm. The amount of drug entrapped in the microspheres was calculated using the formula. Hardness The Pfizer hardness tester was used to determine the tablets hardness. The tablets were held between a fixed and moving jaw, the body of the Monsanto hardness tester carrier an adjustable scale which was set zero against an index mark fixed to the compression plunger when the tablets were held between the jaws. The load was gradually increased until the tablets fractured. The value of the load at that point gave a measure of the tablets hardness. Hardness 5 tablets were determined and the average result was tabulated. Disintegration Time The test was carried out on 5 tablets using tablet disintegration tester ED-20 distilled water at 370C± 20C  was used as disintegration media and the time in seconds taken for complete disintegration of the tablets with no palpable mass remaining in the apparatus was measured in seconds. Friability

The friability of the tablets was measured in a Roche friabilator. Tablets of a known weight (W0) or a sample of 20 tablets are deducted in a drum for a fixed time (100 revolutions) and weighed (W) again. Percentage friability was calculated from the loss in weight as given in a formula 2. The weight loss should not be more than 1%. In vitro Drug Release Study of Bilayered Tablets of MHCl and PHCl 7, 10 In vitro drug release study of bilayered tablets was carried out using USP XXIII basket type dissolution apparatus in two stages. Stage I : Medium: pH 2 hydrochloric acid buffer Time: 2 hours RPM: 100 Stage II : Medium: Phosphate buffer pH 6.8. Time: 10 hours RPM: 100 Samples of 10 ml each were withdrawn at 1 hr intervals for 12 hours. and analyzed spectrophotometrically at first derivative at 269 nm to determine the concentration of PHCl present in the dissolution medium. And samples were analyzed spectrophotometrically at 233nm to determine the concentration of MHCl in the dissolution medium. The initial volume of the dissolution fluid was maintained by adding 10 ml of fresh dissolution fluid after each withdrawal. Kinetics of Drug Release The dissolution profile of all the batches was fitted to Zero order, First order and Higuchi to ascertain the kinetic modeling of the drug release. The method of Bamba et al. was adopted for deciding the most appropriate model. Zero-order In many of the modified release dosage forms, particularly sustained or controlled release dosage forms (those dosage forms that release the drug in planned, predictable and slower than the normal manner), is zero-order kinetic and can be calculated by formula 3, m = k x t …………..3 Korsmeyer Peppa's equation: Mt/M∞ = Ktn……..4 Where Mt is the amount of drug released at time t, M∞ is the amount of drug released after an infinite time, k is a kinetic constant incorporating structural and geometric characteristics of the tablet, and n is the diffusional exponent indicative of the drug release mechanism. In short, the results obtained from in vitro release studies were plotted in four kinetics models of data treatment as follows: Cumulative percentage drug release Vs. Time (zero order rate kinetics) Log cumulative percentage drug retained Vs. Time (first-order rate kinetics) Cumulative percentage drug release Vs. √T (Higuchi’s classical diffusion equation) Log of cumulative percentage drug release Vs. log Time (Peppa’s exponential equation) Evaluation of Bilayered Tablets of MHCL Microsphere and PHCL The selection of directly compressible material is critical in case of tableting of microspheres. Two directly compressible materials were taken in the study described in Table 1 and the tablets were evaluated for drug content, hardness, disintegration time, weight variation and friability. The results of these tests are shown in Table 3. Drug Content                                                             The drug content was found to be in the desired limit for all the tablets. MHCl drug content was found to be higher (82.61%) in case of batch MP2 containing DCP as the directly compressible material and batch MP1 containing MCC as directly compressible material showed 81.54% drug release. In case of PHCl content batch, MP2 showed maximum drug content at 94.35%. Disintegration Time The disintegration time was found to be higher in case of Batch MP1 was 65 sec. and batch MP2 was found to be 56 sec. Friability Friability was found to be less in case of tablets prepared with directly compressible material MCC than DCP. Hardness The hardness of all the tablets was found to be around 4-4.1 Kg/cm2. In vitro Dissolution Study

Figure 2: IR Spectrum of MHCl The results of the dissolution of bilayered tablets were shown in Table 4 and 5 and Fig. 2. All the tablets showed good release in case of PHCl layer. Batch MP2 were showing the maximum release of MHCl from microspheres layer containing DCP direct compressible material. Results Preformulation Studies Identification The IR spectrums of pure drugs were found to be similar to the standard spectrum of MHCl and PHCl. The spectrum of MHCl and PHCl shows the following functional groups at their frequencies as shown in Fig. 3 and Table 6. pH Determination The pH of MHCl and PHCl was found to be 6.68 and 5.5 respectively. Melting Point Determination The melting point of MHCl and PHCl was found to be 222ºC and 188ºC respectively. Solubility Study MHCl was found freely soluble in water; soluble in ethanol and methanol; sparingly soluble in chloroform and practically insoluble in acetone. PHCl was freely soluble in N-N dimethylformamide and 5N acetic acid; slightly soluble in ethanol, acetone, and acetonitrile and practically insoluble in water. Drug Polymer Interaction (FTIR) Study The results of FTIR study for MHCl, HPMC 15k, a combination of MHCl and HPMC 15k, PHCl, and the combination of PHCl and HPMC. Table 2: Results of IR interpretation from spectra Sl. No. IR Spectrum Peaks cm-1 Groups Stretching / Deformation 1 MHCl 2814.24 C – H Stretching 1629.9 C = N Stretching 1577.82 N – H Bending 1386.86 C – N Stretching 729.12 Cl Stretching 2 Physical mixture of MHCl and polymer 2939.61 C – H Stretching 1570.11 N – H Bending 1415.80 C – N Stretching 1267.27 C – O Stretching 3373.61 O – H Stretching 3 PHCl 2924.18 C – H Stretching 1614.47 C = N Stretching 1504.53 N – H Bending 1390.72 C – N Stretching 717.54 Cl Stretching Evaluation of Bilayered Tablets of MHCl Microspheres and PHCl Table 3: Evaluation data of bilayered tablets of MHCl microspheres and PHCl Batch Weight variation (mg) mean ±SD (n=10) Hardness (kg/cm2) (n=5) Friability (%) D.T (sec) (n=5) MHCl content (%) PHCl content (%) MP1 500.2±1.48 4 0.87 59 81.54 92.10 MP2 500.4±2.07 4 0.73 63 82.61 94.35 In vitro dissolution study of bilayered tablets of MHCl microspheres and PHCl Stage 1: In vitro release study for PHCl in pH 2 hydrochloric acid buffer and Phosphate buffer pH 6.8. Table 4: In vitro release data of PHCl layer from bilayered tablets Sl.No. Time (min) % Cum. drug release   MP1±SD MP2±SD 1 0 0 0 2 20 31.66±0.56 43.94±0.47 3 40 41.22±0.88 57.27±0.98 4 60 44.03±1.35 63.03±0.85 5 80 52.58±0.65 76.74±1.20 6 100 77.11±0.75 81.75±1.12 7 120 89.45±1.25 85.02±0.65 Stage 2: In vitro release study for MHCl in pH 2 hydrochloric acid buffer and Phosphate buffer pH 6.8. Table 5: In vitro release study Sl. No. Time (hrs) % Cum. drug release MP1±SD MP2±SD 1 0 0 0 2 1 12.63 ± 0.35 13.16 ± 1.16 3 2 21.92 ± 0.40 26.03 ± 0.98 4 3 28.74 ± 0.80 30.53 ± 0.80 5 4 30.85 ± 0.98 35.71 ± 1.25 6 5 37.76 ± 0.75 41.24 ± 1.30 7 6 43.68 ± 1.20 48.15 ± 0.75 8 7 48.36 ± 0.90 51.58 ± 0.35 9 8 52.29 ± 0.85 56.74 ± 0.45 10 9 57.50 ± 1.12 61.71 ± 0.20 11 10 62.33 ± 1.35 67.37 ± 0.50 12 11 68.18 ± 0.60 72.31 ± 0.65 13 12 70.69 ± 0.75 78.90 ± 1.13 CONCLUSION

Figure 3: In vitro release profile of bilayered tablets of MHCl microspheres and PHCl The present investigation showed that the HPMC can be used to encapsulate MHCl by a solvent evaporation method. The effect of the drug to polymer ratio was studied and form the results, the following conclusions can be made: On the basis of in vitro release studies, E3 was selected as an optimized formulation for designing sustained release formulation. And For further study batch, E3 was used for tableting. For the immediate release PHCl layer it can be concluded that 4% of the HPMC (batch T2) showed maximum drug release hence batch T2 was selected for further process. Studies on the directly compressible materials revealed that DCP was the best directly compressible material than MCC for compressing of MHCl microspheres. The results of the kinetic study showed that the compressed bilayered tablets followed zero order kinetics and coupling of diffusion and erosion mechanism so-called anomalous diffusion mechanism. REFERENCES Gilbert S. Banker, Neil R. Anderson., tablets. In Leon Lachman, Herbert Liebermann, Joseph L Kanig. (Edition), the theory and practice of Industrial Pharmacy, 3rd ed. Lea and Febiger, Philadelphia, 1987, 293-94. PMid:3580553 Chien, Y. W. (1990). Controlled and modulated-release drug delivery systems, In Swarbrick and JC Boyland (Ed.). Encyclopedia of Pharmaceutical Technology. New York: Marcel Dekker, Inc; 281-313. Brahmankar, D. M., Jaiswal, S. B. (2000). Biopharmaceutics and Pharmacokinetics-A treatise. 1st Ed. Delhi: Vallabh Prakashan; 335-75. Gudsoorkar, V. R., Rambhau, D. (1993). Sustained release of drugs. The Eastern Pharmacist, 36(429), 17-22. Robinson, J. R., Lee, L. H. (1987). Controlled Drug Delivery: Fundamentals and Applications, 2nd Ed; 312-31. Available on online URL; wikipedia.com Gilbert S. Banker, Neil R. Anderson., tablets. In Leon Lachman, Herbert Liebermann, Joseph L Kanig. (Edition), the theory and practice of Industrial Pharmacy, 3rd ed. Lea and Febiger, Philadelphia, 1987, p. (a) 293-94, (b) 330-31, (c) 430-31. Watts, P. J., Davies, M. C., & Melia, C. D. (1990). Microencapsulation using emulsification/solvent evaporation: an overview of techniques and applications. Critical reviews in therapeutic drug carrier systems, 7(3), 235-259. PMid:2073688 Paint and Coatings Industry Magazine, January 1st, 2010: Opaque Polyethylene Microspheres for the coatings applications. Vyas S, Khar R. Targeted and Controlled drug delivery: Novel carrier systems. First edition, CBS Publishers; New Delhi; 2006. p. 417-57. PMid:17722276 , PMCid:PMC2676632 Read the full article

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