#GPCR

[last-tarrasque]

what exactly does marxism-leninism-maoism add to marxism-leninism? i know part of it is the theory of protracted peoples war but honestly that seems like it would only work in countries with larger rural areas. this isn't me trying to disprove you or anything i just don't think i understand maoism. (i've also heard mixed opinions on abimael guzman from some people so i'm curious about him too)

That is a great question! The advancements of Maoism can be split into two main categories. The first category is the qualitative advancements with build on the core of Marxism, and mark the transformation of Marxism-Leninism into Marxism-Leninism-Maoism. The second is the advances which advance Maoism itself, but do not propel revolutionary science into a qualitatively higher stage.

In terms of the first category, three main advancements were made which qualitatively advanced the knowledge of revolutionary science along the lines of the three essential aspects of Marxism. These were made during the 3rd world historic revolution, that being the Chinese Revolution, up till the end of the Great Proletarian Cultural Revolution. These are;

Advancements in the field of Political Economy: Chairman Mao Zedung was the first to seriously advance the study of imperialism beyond the great discoveries of Lenin and analyze Imperialism in it's modern Semi-Colonial form. This investigation led to the discovery of Bureaucrat-Comprador Capitalism and Semi-Feudalism, the ruling classes within Semi-Colonies.

Advancements in the field of Class Struggle 1: Following the analysis of Bureaucrat-Comprador Capitalism and Semi-Feudalism, along with analysis of both the RUssian and Chinese Revolution's, Mao discovered a crucial revolutionary stage for all countries under the boot of feudalism and imperialism, that of the New Democratic Revolution. The NDR is a national revolution against Feudalism and Imperialism headed principally by the Proletariat, in alliance with all progressive classes of society, including the national bourgeoises (For example the CPC-Kuomintang united fount against the Japanese, or the united front against the Tzar in Russia) The NDR must be completed before socialist revolution can occur.

Advancements in the field of Class Struggle 2: Another Key advancement of Mao was the discovery that, contrary to popular opinion at the time, class struggle continues under socialism. Under socialism new bureaucratic bourgeoisie emerge from within the party and state structure (following the principle of one dividing into two) and from remaining inequalities in society (following the principle of unequal development). Following the defeat of soviet socialism buy such forces and the rise of Khrushchevite Revisionism, and even the rise of such Revisionism in the CPC, Mao and the socialist line in the party waged a struggle against Khrushchtevite Revisionism and later internal revolution, culminating with the Great Proletarian Cultural Revolution. The GPCR targeted both old feudal and capitalist structures as well as the new bourgeoisie who promoted the capitalist line in the party, and pushed the development of socialism to its farthest point so far (which is why it the 3rd world historic revolution).

Advancements in the field of Dialectical Materialism: Mao's book On Contradictions is edental reading for any serious communist, it contains Mao's contribution to the philosophical foundations of Marxism. It puts forward key concepts such as the relationship between antagonistic and non antagonistic contradiction, differentiates between principle and secondary contractions, and the universality and particularity of contractions. Mao also puts forward in other works how contractions should be handled. Contradictions amongst the people vs contradictions with ractionares, and importantly contractions between the masses and the party, which is solved with the mass line.

There is also the topic of People's War, however that is a topic I personally do not know enough about yet in order to speak on it with any authority. After all, no investigation, no right to speak.

[connorthemaoist]

[newstech24]

Construction Therapeutics: Why Aleniglipron's Path To Market Stays Treacherous (GPCR)

This text was written by Observe With a background as an RN and an MBA, Stephen analyzes healthcare and tech shares by combining scientific perception with rigorous valuation strategies. He focuses on scenario-based DCF modeling, sensitivity evaluation, and Monte Carlo simulations to uncover uneven risk-reward. His focus is on translating advanced science and market dynamics into actionable…

[faultfalha]

Structure Therapeutics: Recent IPO With Large Valuation The company Structure Therapeutics had a successful IPO recently, raising a large amount of money and achieving a high valuation. Some observers say that the company's success is due to its cutting-edge technology, while others claim that it is due to the impressive track record of its management team. Whatever the reason, Structure Therapeutics is a company to watch in the coming years.

[dictatorshipofcapital]

just ran into trans supremacy cgirl tumblr, day ruined

[himedanshicult]

dengists will just regurgitate bourgeois propaganda on "work-shy" proletarians if they can justify it as necessary for "the development of productive forces". ideological cancer

[global-research-report]

G-Protein Coupled Receptors Market Analysis: Drug Development & Research Trends

The global G-protein coupled receptors market size is expected to reach USD 5.23 billion by 2030 registering a CAGR of 5.1%, according to a new report by Grand View Research, Inc. Rising adoption of faster and accurate High-Throughput Screening (HTS) technology by pharmaceutical firms to develop potential G-protein coupled receptor(GPCR)-targeted therapeutics is expected to augment the market growth. HTS is used on the G-protein coupled receptor cell-based assays to assist several drug development programs.

Structural and functional features of G-protein coupled receptors (GPCRs) allow it to mediate physiological responses to hormones, stimulants, and neurotransmitters, thus making them as potential therapeutic targets for various diseases. Recent advancements in the structural biology of GPCRs have provided insights into the molecular mechanisms of these receptors’ activation and activity. Several pharmaceutical companies are undertaking efforts to develop G-protein coupled receptors-targeted therapeutics for several disorders.

In December 2018, Boehringer Ingelheim collaborated with Domain Therapeutics to discover GPCR targets for the treatment of cancer, Central Nervous System (CNS), and immunological disorders. Moreover, in May 2019, Evotec OAI AG partnered with Euroscreen S.A. to improve its capabilities for GPCR targeting. Evotec OAI will access GPCR reagents and AequoScreenTM technology of Euroscreen for its drug discovery procedures. Such initiatives enhance the product adoption as well as drug screening expertise in the pharmaceutical industry.

North America is likely to be at the forefront of the market throughout the forecast period due to heavy investments in cancer research to address the rising demand for drug discovery and development procedures in U.S. Whereas, Asia Pacific is expected to register the fastest CAGR over the forecast years. The region witnesses a rising number of therapeutics development and contract research, thus boosting G-protein coupled receptors market growth.

G-Protein Coupled Receptors Market Report Highlights

Easy availability of cell lines products and a large number of companies offering a variety of cell lines resulted in the largest revenue share of cell lines in 2022

Increasing usage of fully equipped detection kits instead of cell lines, reagents, and ligands separately, marks the potential growth of detection kits in the near future

cAMP assays serve as a versatile platform in HTS for explaining the GPCR functions, which results in maximum revenue generation from these type of assays

Cancer research application accounted for the largest revenue share in 2022 owing to increased number of cancer cases and investments in oncology R&D

Ongoing research studies to evaluate the pharmacology of GPCRs in chronic inflammatory disorders reveals immense opportunities for research in inflammatory applications

Acquisition, partnerships, and collaborations are the major strategies adopted by these companies to offer new GPCR-targeted medicines, thereby strengthening their presence in the global GPCRs market

G-Protein Coupled Receptors Market Segmentation

Grand View Research has segmented the global G-protein coupled receptors market on the basis of product, assay type, application, and region:

GPCRs Product Outlook (Revenue, USD Million, 2018 - 2030)

Cell Lines

Detection Kits

Cell Culture Reagents

Ligands

GPCRs Assay Type Outlook (Revenue, USD Million, 2018 - 2030)

cAMP Functional Assays

Calcium Functional Assays

β-Arrestin Functional Assays

Radioligand Binding & GTPγS Functional Assays

Internalization Assays

Trafficking Assays

Other Assays

GPCRs Application Outlook (Revenue, USD Million, 2018 - 2030)

Cancer Research

CNS Research

Metabolic Research

Cardiovascular Research

Respiratory Research

Inflammation Research

Other Applications

GPCRs Regional Outlook (Revenue, USD Million, 2018 - 2030)

North America

US

Canada

Europe

UK

Germany

France

Italy

Spain

Denmark

Sweden

Norway

Asia Pacific

Japan

China

India

Australia

Thailand

South Korea

Latin America

Brazil

Mexico

Argentina

Middle East & Africa

South Africa

Saudi Arabia

UAE

Kuwait

Key Players in G-Protein Coupled Receptors (GPCRs) Market

Thermo Fisher Scientific Inc.

Eurofins Scientific

QIAGEN

WuXi AppTec

Promega Corporation

Abcam plc

Merck KGaA

PerkinElmer Inc.

Enzo Biochem Inc.

BD

Order a free sample PDF of the G-Protein Coupled Receptors (GPCRs) Market Intelligence Study, published by Grand View Research.

[pudknocker]

この「臓器提供の意思」は弁護士の発案なんだろうけど、本当にえげつないんだよな。 臓器提供は原則親族や配偶者からしかできない。 婚姻関係自体が解消されたら、ドナーのあてがなくなる。だから夫である被害者が妻である加害者に厳罰を望む証言をすることは難しくなる。 そして判決確定後に臓器提供をバックレても罰則はない。

XユーザーのYS@GPCRさん

[fuckyeahmarxismleninism]

Women's Militia during the Great Proletarian Cultural Revolution, Inner Mongolia, 1969.

Via GPCR Podcast

[hellsite-proteins]

Hey guys, did you know that in terms of human companionship, Flareon is objectively the most huggable Pokémon? While their maximum temperature is likely too much for most, they are capable of controlling it, so they can set themselves to the perfect temperature for you. Along with that, they have a lot of fluff, making them undeniably incredibly soft to touch. But that's not all, they have a very respectable special defense stat of 110, which means that they are likely very calm and resistant to emotional damage. Because of this, if you have a bad day, you can vent to it while hugging it, and it won't mind. It can make itself even more endearing with moves like Charm and Baby Doll Eyes, ensuring that you never have a prolonged bout of depression again.

this is actually so sweet!

letter sequence in this ask matching protein-coding amino acids:

HeygysdidyknwthatintermsfhmancmpaninshipFlarenisectivelythemsthggalePkemnWhiletheirmaimmtemperatreislikelytmchfrmsttheyarecapalefcntrllingitstheycansetthemselvesttheperfecttemperatrefryAlngwiththattheyhavealtfflffmakingthemndenialyincredilysftttchtthatsntalltheyhaveaveryrespectalespecialdefensestatfwhichmeansthattheyarelikelyverycalmandresistanttemtinaldamageecasefthisifyhaveaaddayycanventtitwhilehggingitanditwntmindItcanmakeitselfevenmreendearingwithmveslikeCharmandayDllEyesensringthatyneverhaveaprlngedtfdepressinagain

protein guy analysis:

my first thought was just that this one looks like an accordion. the helices are arranged in something approximating a line, and this protein looks like it's been flattened. one end has a pretty long loop, but otherwise this has a good amount of secondary structure. its absolutely not hydrophobic enough to be a transmembrane protein, but for some reason this reminded me of some illustrations i've seen of GPCR receptor proteins. (i saw one picture that was a parody of the old magnificent 7 movie poster, with each of the people as a transmembrane helix, but i couldn't find it again to include in this post :/ ). now that i've made several loose comparisons, its time for my regular disclaimer that this still doesn't look like anything. the pLDDT colours are similar to the colours of this pokemon – which is to say very orange! none of this is real and it shouldn't be trusted in the slightest.

predicted protein structure:

cartoon representation coloured by pLDDT

cartoon rotated 90º

movie poster i referenced above

[wwwwwwwwwwww123]

(XユーザーのYS@GPCRさん: 「Error: object not found "学生時代に付き合っていた人"」 / Xから)

[communist-ojou-sama]

In one of your recent posts you made a distinction between Maoist and Marxist-Leninist-Maoist. I wasn’t aware there was a difference, I sort of thought Maoist was just shortening the whole term. Could you explain what distinctions there are between the two?

As I understand it Maoism tends to be more of a theory of revolution and protracted asymmetrical struggle against an established state enemy, with ideological and geopolitical thought that extends from the ideological lines that developed through Mao's tenure as head of the CPC through to the GPCR, and developed further by responses to Mao Zedong thought, especially by other guerilla groups that focus on organizing the peasantry. Notably, as I understand it Maoist groups while not anarchist often reject the idea of a vanguard party. So the communist guerillas in eastern India and the Philippines, for example, are Maoist, but not Marxist Leninist Maoist

Marxism Leninism Maoism is the application of certain aspects of both Mao Zedong Thought and also organizing innovations of the CPC at large throughout its entire history, including after the GPCR, as adjustments to what they consider to be contradictions within Marxism Leninism that the CPC managed resolved with ideological and organizing innovations (such as the mass line). However MLM is fundamentally democratic centralist like Leninism, and in terms of it's theory of revolution is fundamentally vanguardist (if indeed my understanding is correct)

[faultfalha]

Superluminal, a startup that harnesses the power of quantum mechanics to develop treatments for cancer and other diseases, has announced that it has secured investment from RA Capital Management and Nvidia. The company is focused on discovering and developing drugs that target GPCRs, a class of proteins that are involved in almost every major biochemical process in the body.

[humancelltournament]

Propaganda!

Bone cells, called osteocytes, are an oblate shaped type of bone cell with dendritic processes, and are the most commonly found cell in mature bone. It can live as long as the organism itself. The adult human body has about 42 billion of them. Osteocytes do not divide and have an average half life of 25 years. They are derived from osteoprogenitor cells, some of which differentiate into active osteoblasts (which may further differentiate to osteocytes). Osteoblasts/osteocytes develop in mesenchyme.

Neuropeptides are chemical messengers made up of small chains of amino acids that are synthesized and released by neurons. Neuropeptides typically bind to G protein-coupled receptors (GPCRs) to modulate neural activity and other tissues like the gut, muscles, and heart. Neuropeptides are synthesized from large precursor proteins which are cleaved and post-translationally processed then packaged into dense core vesicles. Neuropeptides are often co-released with other neuropeptides and neurotransmitters in a single neuron, yielding a multitude of effects. Once released, neuropeptides can diffuse widely to affect a broad range of targets.

[leomacgivena]

中国韓国シンガポールあたりって、日本の高度成長からバブルを早回ししてるような感じなんだよな。経済成長著しい一方で少子化がすさまじい勢いで進んで、数十年後には老人だらけで生産性が落ちるのが約束されてる。日本と同じような長期停滞を迎えるだろう。

XユーザーのYS@GPCRさん

[delusionalnerdt]

23 September 2024

Year 2 Day 16

Clinical posting : Patient 1 with generalised weakness (must be anemic), patient 2 with tremor

Pharmacology : revision class of Pharmacodynamics (came earlier because I almost had a syncope)

Practical (pathology) : acute inflammation. Gross : appendicitis, Slide : cholecystitis

📕 Revision of GPCR, TI, TW

📕 Acute inflammation : morphology, outcome, PG