#Hematology & Blood Research

[prachicmi4]

Hemoglobinopathy Treatment Shows Promising Growth Trajectory Through Advanced Therapeutics

Hemoglobinopathy represents a group of inherited blood disorders that affect the structure or production of hemoglobin, the protein responsible for carrying oxygen throughout the body. These genetic conditions encompass sickle cell disease, thalassemia, and various other abnormal hemoglobin variants that collectively impact millions of individuals worldwide. The complexity of these disorders has driven significant research initiatives and therapeutic developments, transforming the landscape of treatment options available to patients suffering from these debilitating conditions. Hemoglobinopathy disorders arise from mutations in the genes responsible for producing alpha and beta globin chains, the fundamental components of adult hemoglobin. Sickle cell disease, the most prevalent form, results from a single amino acid substitution in the beta-globin chain, causing red blood cells to assume a characteristic sickle shape under deoxygenated conditions. This structural abnormality leads to vascular occlusion, chronic pain crises, organ damage, and reduced life expectancy. Get more insights on, Hemoglobinopathy

[aarunresearcher]

United States point of care diagnostics market size is projected to exhibit a growth rate (CAGR) of 6.90% during 2024-2032. Numerous advancements in portable and handheld diagnostic devices have enhanced the convenience and user-friendliness of testing, which is primarily driving the market growth.

[vonbabbitt]

Sorry if this is too personal a question, but do you have a background in biology/hematology as well as being a teacher? You speak the language pretty well. I’m a medical lab scientist so it’s part of my job to look at blood and help doctors diagnose cancer, and the descriptions of it in Staffside (especially the one related to AML) were pretty accurate. I just thought it was neat, I always get excited when biology/science is accurate in fictional media. I’m a huge nerd for CRISPR-Cas9 and cancer research :3

i do not! im glad i came off as convincing though lmao!!

[lotus-tower]

COVID-19's long-term effects on the body: an incomplete list

COVID’s effect on the immune system, specifically on lymphocytes:

NYT article from 2020 (Studies cited: https://www.biorxiv.org/content/10.1101/2020.05.18.101717v1, https://www.biorxiv.org/content/10.1101/2020.05.20.106401v1, https://www.unboundmedicine.com/medline/citation/32405080/Decreased_T_cell_populations_contribute_to_the_increased_severity_of_COVID_19_, https://www.medrxiv.org/content/10.1101/2020.06.08.20125112v1)

 https://www.biorxiv.org/content/10.1101/2022.01.10.475725v1

https://www.science.org/doi/10.1126/science.abc8511 (Published in Science)

 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057012/

https://www.forbes.com/sites/williamhaseltine/2022/04/14/sars-cov-2-actively-infects-and-kills-lymphoid-cells/

https://www.cleveland.com/news/2022/10/in-cleveland-and-beyond-researchers-begin-to-unravel-the-mystery-of-long-covid-19.html

SARS-CoV-2 infection weakens immune-cell response to vaccination: NIH-funded study suggests need to boost CD8+ T cell response after infection

https://www.merckmanuals.com/professional/hematology-and-oncology/leukopenias/lymphocytopenia

https://thetyee.ca/Analysis/2022/11/07/COVID-Reinfections-And-Immunity/

Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1034159/full

https://www.n-tv.de/politik/Lauterbach-warnt-vor-unheilbarer-Immunschwaeche-durch-Corona-article23860527.html (German Minister of Health)

Anecdotal evidence of COVID’s effects on white blood cells:

 https://twitter.com/DrJohnHhess/status/1661837956875956224

 https://x.com/TristanVeness/status/1661565201345564673

https://twitter.com/TristanVeness/status/1689996298408312832

Much more if you speak to Long Covid patients directly!

Related information of interest:

China approves Genuine Biotech's HIV drug for COVID patients

COVID as a “mass disabling event” and impact on the economy:

https://www.ctvnews.ca/health/report-says-long-covid-could-impact-economy-and-be-mass-disabling-event-in-canada-1.6306608

https://x.com/inkblue01/status/1742183209809453456?s=20

COVID’s impact on the heart:

https://www.dailystar.co.uk/news/world-news/deadly-virus-could-lead-heart-31751263 (Research from: Japan's Riken research institute)

https://www.brisbanetimes.com.au/national/queensland/unlike-flu-covid-19-attacks-dna-in-the-heart-new-research-20220929-p5bm10.html

https://www.mdpi.com/2077-0383/12/1/186

https://medicalxpress.com/news/2023-04-mild-covid-effects-cardiovascular-health.html

https://publichealth.jhu.edu/2022/covid-and-the-heart-it-spares-no-one

https://www.bhf.org.uk/informationsupport/heart-matters-magazine/news/coronavirus-and-your-health/is-coronavirus-a-disease-of-the-blood-vessels (British Heart Foundation)

COVID’s effect on the brain and cognitive function:

https://www.openaccessgovernment.org/article/brain-infection-by-sars-cov-2-lifelong-consequences/171391/

https://www.cidrap.umn.edu/covid-19/study-shows-covid-leaves-brain-injury-markers-blood

https://www.theguardian.com/world/2020/jul/08/warning-of-serious-brain-disorders-in-people-with-mild-covid-symptoms

Cognitive post-acute sequelae of SARS-CoV-2 (PASC) can occur after mild COVID-19 

Neurologic Effects of SARS-CoV-2 Transmitted among Dogs

https://journals.lww.com/nsan/fulltext/2022/39030/neurological_manifestations_and_mortality_in.4.aspx

https://www.salon.com/2023/06/17/new-evidence-suggests-alters-the-brain--but-the-extent-of-changes-is-unclear/

https://www.scientificamerican.com/article/covid-virus-may-tunnel-through-nanotubes-from-nose-to-brain/

https://neurosciencenews.com/post-covid-brain-21904/

https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(22)00260-7/fulltext

https://medicalxpress.com/news/2022-08-covid-infection-crucial-brain-regions.html

https://news.ecu.edu/2022/08/04/covid-parkinsons-link/

Covid as a vascular/blood vessel disease:

https://www.salon.com/2020/06/01/coronavirus-is-a-blood-vessel-disease-study-says-and-its-mysteries-finally-make-sense/

https://www.salon.com/2023/12/27/brain-damage-caused-by-19-may-not-show-up-on-routine-tests-study-finds/

https://www.nih.gov/news-events/news-releases/sars-cov-2-infects-coronary-arteries-increases-plaque-inflammation

https://www.mdpi.com/2077-0383/12/6/2123

https://www.sciencedaily.com/releases/2021/10/211004104134.htm (microclots)

Long Covid:

Post-COVID-19 Condition in Canada: What we know, what we don’t know, and a framework for action

 https://www.ctvnews.ca/health/coronavirus/more-than-two-years-of-long-covid-research-hasn-t-yielded-many-answers-scientific-review-1.6235227

 https://www.cbc.ca/news/canada/london/cause-of-long-covid-symptoms-revealed-by-lung-imaging-research-at-western-university-1.6504318

 https://www.cbc.ca/news/canada/montreal/long-covid-study-montreal-1.6521131

https://news.yale.edu/2023/12/19/study-helps-explain-post-covid-exercise-intolerance

Other:

- Viruses and mutation: https://typingmonkeys.substack.com/p/monkeys-on-typewriters

Measures taken by the rich and world leaders

Heightened risk of diabetes

https://jamanetwork.com/journals/jama/fullarticle/2805461

https://www.nature.com/articles/d41586-022-00912-y

Liver damage:

https://timesofindia.indiatimes.com/city/mumbai/46-of-covid-patients-have-liver-damage-study/articleshow/97809200.cms?from=mdr

tl;dr: covid is a vascular disease, not a respiratory illness. it can affect your blood and every organ in your body. every time you're reinfected, your chances of getting long covid increase.

avoid being infected. reduce the amount of viral load you're exposed to.

the gap between what the scientific community knows and ordinary people know is massive. collective action is needed.

[lightaflaem]

𝐃𝐀𝐘𝐋𝐈𝐆𝐇𝐓 [𝐨𝐧𝐞]

content warnings: heavy gore, zombies, infectious disease, mentions of blood, hospitals, cheating, profanity, violence, usage of weapons and guns, mental health problems, implied anxiety attacks, explicit smut, oral (f!receiving), fingering, protected sex

word count: 5.5k

summary: just when everyone thought that the flu-like virus which led to a global outbreak four years ago had finally settled down, a new variant struck that escalated rapidly and became out of control. with limited supplies and life at stake, you were left with no choice but to team up with your ex-boyfriend, oikawa tooru, to navigate and seek shelter.

keiya.speaks: this is an entry for @pixelcafe-network 's 2024 spooktober event 🎃

series masterlist | next part

You wished that all of this was just inside of your head.

You begged the ups that once you open your eyes, you’ll be in your favorite figs scrub suit, caressing your Beckman Coulter DxH 900 hematology analyzer, praying that the reagents would be enough for your hospital’s bed capacity as your laboratory supervisor forgot to place an order for this month’s supplies.

Or maybe wooing your Cobas e601, hoping that your quality control would be in the range of the mean so you would be able to run all your chemistry specimens smoothly. Maybe when you finally open your eyes, you’ll be back inside the laboratory, signing all your patients’ results as a Medical Laboratory Scientist.

However, when your eyelids unfolded and a baseball bat swung towards you that nearly grazed the tip of your nose, you were back in this stinking reality.

“I swear to fucking hell, Tooru, stop spinning the bat like that, you nearly hit me again!” you hissed, trying to avoid the piece of wood for the nth time. Your eyes caught a glimpse of the nip of skin that has been hanging around the bloody barbed wires wrapped around it for heavens knows how long and instantly, you felt your insides turning upside down, nearly throwing the acid of your stomach in disgust. 

“Aww, chibi-chan is annoyed, you’re too cute to be annoyed. You can’t be annoyed at me, darling. You’re stuck with me.” Tooru smiled, his eyes turning crescents while grabbing a few cans of easy-open tuna paella and throwing it into the creaky shopping cart.

You’re back in this reality where everyone around you has turned into a living dead—basically zombies. People might think that this is just a foolish tale told by someone like you however, it wasn’t. When everyone thought that the Corona virus that set the world into a pandemic four years ago had ended, well it hasn’t really ended that well yet.

A new variant mutated and current vaccines didn’t work that much into protecting the people. Eventually. Everyone started getting sick again and the cases doubled, tripled, and continued proliferating like hell. Hospitals were full of patients with flu-like symptoms and quarantine was implemented once again. With the lack of research and scientific approach, never have you ever imagined that the simple flu virus that was once contained will mutate into something more damned, something more hellish—and that is taking over its host’s nervous system and respiratory tract, owning it completely just like the mad cow and rabies disease. At this point, you didn’t really understand it that much because there’s a lot of factors and unknown elements. With that, the once feared virus has already taken over the world again but this time, much worse than the first one.

Two weeks since the virus has flipped Japan 360 degrees, 14 days of being stuck to survive with Oikawa Tooru, your ex-boyfriend. 

Shit happens for real, right? But when that menace, caramel-eyed, 6 footer guy who dragged his best friend, Iwaizumi Hajime, into his shenanigans suddenly showed up in your workplace with a bouquet of flowers 3 years after your break-up, you felt your blood boiling as the last thing you wanted to see is his face.

And another shit happens is that the very same day he showed his arrogant face to you, that’s also the day when the whole city went rabid and everyone suddenly started biting each other as the undead symptoms manifested in most of your emergency room patients. It was like a trigger that suddenly detonated, sending signals to all of the infected to attack.

That’s how you found yourself in an abandoned grocery, picking up some goods before you eventually hit the road to seek a temporary shelter while looking for a permanent one with your ex-boyfriend, who’s now taking advantage of the life or death situation to get closer to you once more.

“Phew, looks like we got everything we needed.”

Your gaze shifted to the items inside the cart. Canned goods, instant meals, protein bars, biscuits, some snacks, bottled waters that could probably last up to a few days depending on the consumption, energy drinks, basic medicine and first aid, batteries, ropes, some toiletries and personal necessities, and a box of condoms.

Box of condoms?

“Oikawa Tooru, you perverted sex animal!” you felt your face heating up despite the broken air conditioner kept on running, setting the whole area into freezing point.

Tooru was laughing his ass off as you picked up and threw the packets of rubber on his chest. He was bursting so much that he dramatically wiped his fake tears.

“We’re in the middle of a fucking apocalypse and you still have the time to pull shitty pranks just like that!” you exclaimed, face puffing in vexation. “If you don’t have a goddamn thing to do—”

“GRRAAAGH!”

“Fuck!”

A squeal leaped out of your mouth as you saw a flesh-rotting guy approaching Tooru from behind. It let out a deafening howl, echoing in the empty store. Its skin was pale, almost white with purple veins popping in its throat up to its face. The pieces of tissue that were decomposing and filled with maggots were falling into the floor, scattering everywhere. Eyes were bloodshot and scarlet red blood was pouring out of its mouth, approaching the both of you with speed. It can fucking run?! 

In an instant, Tooru secured you behind his back and gripped on the bat’s handle with force. As the raving undead approached, he swung the piece of wood with full strength, leaving a huge missing chunk on the man’s head as the muscle flew away due to the impact. Blood spurted out everywhere and you could see pieces of its brain being tangled in the barbed wires. It fell on the ground convulsing before becoming motionless, indicating that it’s already finally dead again.

“Are you okay, Y/N?” Tooru’s eyes landed on you, checking you from head to toe.

You were frozen in your place, still trying to comprehend what happened. It wasn’t the first time that you were attacked yet you could still feel your insides being scrambled whenever you’re placed in the exact situation. You felt like you’ll seriously never gonna get used to this scenario.

“Y-yeah, I’m alright. A-are you okay?” you questioned, meeting his brown orbs back. Tooru just laughed hysterically, pushing his hair back and settling the wood just above his shoulders.

“Of course! It’s the grand king after all.”

Piece of shit. You thought. He’s already 27 yet the silly nickname that he was given way back in his junior high volleyball days were still fixated on him. He’s a serious menace.

“C’mon, Iwa’s probably wondering why the hell we’re taking too long. As much as I wanted to say that we took this precious time to make out, I’d rather not.” he commented as he pushed the cart forward. You could see from his back how his gaze changed, sensing if there’s still a threat around you.

When the both of you exited the store, you were greeted by your two companies.

“Y/N! Are you alright?” Tobio hurriedly went towards you, examining your physical state. “We heard the noise from outside. We're ready to barge in, you know?”

“Oi. I’m here. Why didn’t you ask me too?” Tooru sniggered in annoyance as the black-haired man continued ignoring him as he was not existing at all. Of course, the former did not let it go and started a childish, rivalry eye to eye against each other.

It was just broken when Iwaizumi squeezed himself in between to check the items inside the cart.

“You guys forgot my snickers, you fuckers.” his forehead creased when he did not catch a glimpse of his favorite chocolate bar that he clearly instructed earlier. You mentally slapped your head as you realized it just now.

“Now Iwa-chan, this is not the right time to freaking enjoy a chocolate bar.”

“Shut the fuck up, you trash. I’ll stuff this cart into your mouth.”

“And I love you too, Iwa-chan!”

Both you and Tobio stood there with a facepalm on your faces as you watched the two best friends bicker with each other in the middle of goddamn ruins. Some people wouldn't be convinced that they have been friends since high school but they really are.

One of the few good things despite the catastrophe is that you somehow luckily ended up with the people you’ve already known. When your workplace turned into madness, Tooru and Hajime managed to pull you away from the crowd of insanity to hide and ended up escaping together safely to the hospital’s parking lot. However, little did the three of you know that there’s also a few undead lurking there. You felt the numbness taking over your body as you recognized some of them as your colleagues—Yamaguchi Tadashi, a nurse on the 6th floor and Sugawara Koshi, a pediatric resident. They were moving mindlessly, drool dripping on their lips as they no longer recognized their own self.

Before Tooru could drag you away from it, a familiar Suzuki Jimny in solid kinetic yellow stopped in front of you. The door flew open, revealing Kageyama Tobio, a phlebotomist and your college friend, screaming to the three of you to get inside the car.

And that’s how you ended up navigating the now ghost roads of Miyagi with these three. The first instinct is to drive to the government facilities in Tokyo to get help; however, it is nearly impossible to reach your destination when you’re unarmed, have no supplies, and do not know what terror lies ahead on those roads. Good thing is that there’s still electricity and water, however, cellular phone signals and wifi are now down so you couldn’t get any help through local authorities. With that, the three of you decided to stick with each other to gather and prepare everything you needed and move little by little at a time.

“Man, you seriously have horrible taste in color.” Tooru spoke to Tobio as he closed the door of his Suzuki Jimny, clearly provoking the younger one instead, all he received was a scoff, ignoring his remark.

“Tooru, stop it.” you berated your ex-boyfriend and blew you a kiss instead that made your eye roll heavenly.

In no time, you’re back on the road with Hajime driving, Tobio on the passenger seat, leaving you and Tooru in the backseat. Your itinerary for today is to find a house to stay in for a few days before finally driving out of Miyagi for good since the last house you went to got infested with undead.

Every night, you get nightmares from the images of the undead. Whenever you dream about it, it’s always detailed to the point that you could smell the malodorous odor of the rotting bodies. The terrifying screams were also echoing in your eardrums that sometimes sent a strike of headache on your head. But sometimes, you also dream about your life before all of this happens. Your happy life whom you’ve worked hard to achieve. Somehow, you managed to pull yourself together otherwise, you’ll lose your sanity and even worse, become one of the undead. However, you really don’t know how long you could still hold yourself in one piece.

“A penny for your thoughts?” Tooru managed to tickle your sides as your mind was hastily floating in cloud nine. You turned to him and saw his soft gaze locking on you. You noticed how his hazel hair that matched the color of his eyes is now cropped into a shorter one compared to its length when you were still dating him three years ago. He’s also wearing a graded specs now whom you did not recall him having one before. His pointed nose and chiseled jaw are now more prominent due to the weight and baby fats he lost. Arms and body became more muscular, skin got a little tanner than usual probably because of his training in Argentina as a professional volleyball player.

Tooru’s really handsome. He’s got the type of attractiveness where you’ll look over your shoulders to glimpse at him once again whenever he passes by. Despite his childish personality, he’s really kind and a gentleman that made him easy to penetrate inside the heart of his crowd. He’s got the aura wherein he can bring the best out of you when you’re with him. He's like the daylight you’ll see when you reach the end of the night sky.

Your relationship with him was stable. You fight but all the arguments are talked and reflected thoroughly. He always gives you whatever you want and need. Handles your tantrums very well and does not hold grudges against you or anyone else. He makes sure that he can show and make you feel all the love languages he could ever think of. He’s the best boyfriend and best friend you’ve ever had. It was so strangely stable to the point that you thought that he’s the one you’ll marry. However, when he accidentally left his phone in your apartment and you caught a glimpse of a contact with a picture of a girl asking if he had fun last night with her on his text messages, your dream of marrying him and being each other’s end game shattered.

He tried calling and chasing you for almost a week after that but you didn’t give him a chance to explain, knowing that only bullshit will come out of his mouth after he blatantly cheated on you just like that. After that, the only news you heard about him is that he’s flying to Argentina to turn his dreams into reality of becoming a professional volleyball player. He never tried contacting you again after that, not even once.

Three years later, he finally achieved his dreams as he’s all over the news as the best setter CA San Juan has ever had and now he’s suddenly back as if nothing happened between the two of you, alive and kicking. 

“Nothing, just tired.” you lied, not having any energy left to converse with him. You felt a calloused, warm hand placed above your left elbow, thumb caressing your skin. Your eyes flew and saw Tooru’s bruised and wounded hand attempting to soothe yours. “What the hell—”

“It’ll be alright, Y/N. I promise you. We’ll get through this, just like we always have.” he left out a soft yet reassuring smile before releasing your arm. You don’t know why but you felt like a hope ignited inside you. A sense of solace hit as you felt that Tooru never once had second thoughts in you. 

You find yourself erupting a small smile. There’s indeed hope despite the darkest times.

Standing in front of a 2-storey modern house, you clutched your baseball bat as you prepared yourself for a possible undead atack. It wasn’t that big but it’s enough for a family of three to live in. The exterior has a monochrome color palette with wooden doors and tinted glass windows that reflect your worn out states. It also has a balcony that has a few clothes hanging on the railing.

“Do you think it’s safe?” Hajime looked up at the towering building.

“I hope so.” Tobio answered, leading towards the door.

Slowly, Tobio twisted the automated door knob that surprisingly opened without any difficulty. The four of you exchanged looks, swallowing the balling lump in your throats as you set a foot inside the house. You were greeted by an eerie silence upon entering the abandoned house. It was decorated with lavish interiors and monochromatic palette, matching with the exteriors. The floor is made with oak wood and the walls are marble that added extra fire to the aesthetics. The second floor has a bathroom, one master bedroom, a guest room with two beds and a balcony that faces the streets. Overall, it’s a nice house and seems like the owner is well-off based on their residence.

Hajime and Tooru checked the second floor and found nothing but a few pieces of clothes that seemingly belonged to a man. However, inside the closet of the master bedroom, they found a leather bag of guns, ammunition and a copy of the firearm’s registration. You were not knowledgeable that much in firearms but you immediately recognized AK-47, M16, and the famous Smith & Wesson Model 27 that you once saw in the anime Banana Fish.

“Damn, so those really exist in real life.” Tooru made an exaggerated comment as the weapons were carefully being laid in the long coffee table by Tobio.

“We’re already in an apocalypse, you shithead. Guns like these are more realistic than this fucking hell situation.” Hajime retorted, blood is always boiling at his best friend’s idiocratic remarks.

“Let’s just keep these in one place and take it once we’re moving away. For now, let’s stick with our current weapons so we can utilize everything at once.” you proposed, earning quick nods from the boys.

“Ah, my darling is so clever! Come and give me a hug.” attempting to cage you in his chest, you quickly dodged your ex-boyfriend's arms and pointed the baseball bat a few inches away from his face.

“Don’t you dare touch me, Oikawa.”

“Why? You loved my touches. You were begging for my touch—”

“Shut it!”

You shused him by swiftly covering his mouth with your right hand. You could feel his lips twitching against your touch, eyes forming a curve as he smiled infuriatingly.

“Love birds, take your business upstairs. Me and Tobio will share the guest room, the two of you in the master bedroom so you can make peace with your demons. Don’t think of bitching up because I ain’t taking any shit today.” Hajime firmly said before grabbing the weapons one by one to store them in the small compartment under the coffee table. You felt your face being flushed with much embarrassment as the two guys witnessed your bantering. Tobio was about to appeal but he met the death stare of Hajime, making him pursed his lips.

You couldn’t even remember the last time you shared a room with your ex-boyfriend. The whole 14 days with him, you either get your own space or share a room with all of them. That's why your vital organ is now leaping so hard that it might jump out of your ribcage.

After arranging and dividing the supplies so that it can last for a few days, the four of you improvised a barricade on the door and covered the window so that you wouldn’t see the streets outside that holds a few abandoned cars, splurt of blood on the road, decomposing human pieces, and some bodies that are unrecognizable.

Seeing the first-aid kit that you grabbed earlier in the kitchen counter, the memory of Tooru’s wounded and bruised hand suddenly flashed in your mind. Without a second thought, you found yourself getting ice from the functional freezer and wrapping it in a clean cloth before wetting the piece of fabric so that the cold temperature could easily penetrate. In no time, you were now standing in front of the master’s bedroom, slowly peeking to see if Tooru’s awake.

You saw him sitting on the edge of the bed that is facing the door, clutching a polaroid film in his hand. His face is blank yet a void of sadness was swarming in his brown eyes as he sighed and kept the picture back in his wallet. Your lips parted as you recognized that he’s still using the wallet you gifted him on his last birthday before you broke up.

“Tooru?” you spoke, casually pushing the door. “Can I come in?”

He let out a chuckle. “Of course you can.”

With that, you slid your body inside the room. His eyes were fixated on you as you sat down beside him, placing the kit on your lap. Your hands were trembling as you reached for him, which he willingly lifted without any question, gently patting the iced towel on his bruises that he probably got from mishandling the baseball bat.

“Wow, never have I ever imagined that I’ll get a special treatment from a medical laboratory scientist. You know you can just kiss the boo boo and it’ll go away instantly.” he winked, making you roll your eyes at him again.

“Shut up. My treatment fee is really expensive for idiots like you.” picking up the disinfectant, you slowly rubbed it on the sides of the small cuts with a clean cotton ball, earning a winced from him as the sting penetrated the wound.

Tooru was silent the whole time you’re icing and dressing his hand. He knows that whenever you're doing something healthcare related, you don’t want to be disturbed as you pour your hundred percent concentration into it. He knows this better than you.

“You never gave me a chance to explain myself, Y/N.” he opened up when he saw you finished sealing the wrapped gauze pad around his palm. “At least let me explain this time. I cannot swallow the fact that we’re already in the middle of this goddamn situation and you still haven’t got the peace of mind you deserve.”

You could feel his stare burning at you. When you met his eyes, it was full of perseverance as if he’s not going to let you exit the room without listening to his explanation. To be honest, you really don’t know to yourself why you’re refusing to hear his side. Maybe you’re afraid of the confrontation. Maybe you’re scared of the fact that he cheated and he’s going to confess it in front of your face. Maybe you’re rejecting the reality that Oikawa Tooru did cheat on you with somebody else.

Gathering all your strength, you let out a deep exhale before speaking. “Give me a reason not to kick you out of this room.”

Tooru’s demeanor changed when he heard those words. It was hard for him to gain your trust once again after everything but if he’s given the chance, he will never let go and prove himself to be worthy of your heart once again.

“It was a prank.” he started, making your face puzzled. “It was a fucking shitty prank pulled by my teammate, Kindaichi. I remember him doing the same thing to Kunimi before but we all laughed it off since Kunimi’s single. I don’t remember when he did it but I think when I left my phone in the locker. He changed his number’s contact photo and name into a girl’s name. After that I went straight to your apartment. I seriously forgot the existence of my phone that day since we’re really having fun and I was late for my practice the next day. When Kindaichi heard that I left my phone somewhere, he texted it and that’s the part where you saw it and thought that I was cheating on you. I confronted him after that with Iwa-chan. That's why I know all of it and he said sorry. I never spoke to him after that.”

He let out a sad smile. “That’s basically everything. I tried contacting you, calling, messaging, and waited outside of your apartment for three hours but you weren’t there. I really wanted to talk with you because we both know that I’ll be leaving for Argentina in a few weeks but yeah, it happened and we can’t really change anything about it anymore.”

Tooru’s bandaged hands slowly made its way to yours, clasping both of his palms on your hands. “I’m so sorry that I let it go just like that. I know that I’m three years late but if there’s anything that I can do to make everything right again, I’ll prove it to you in any way you want just to trust me once again. Even as just friends…Y/N, you’re the best girlfriend and best friend I ever had in my whole life and thinking about everything that happened between us and how it ended just like that puts me in misery.”

Fuck. you thought. You don’t know if the world is playing with your vulnerability right now but after hearing everything, you feel like you’re stoned in your place. You feel like your insides are being scrambled and you wanted to vomit every single thing you ate for the last 14 days with him. All this time, it was a prank. A fucking prank that caused so much damage in both of your lives and relationship. A prank that made you lose your former significant other. And the most fucked up thing about it was you could’ve done something to prevent your relationship from crumbling down. It was completely in your control yet you let him slip away from your finger. If it wasn’t for your stubbornness, Oikawa Tooru is still your partner until today.

“Shit! Y/N, I—sorry! Fuck, please don’t cry.” Tooru panicked when he saw the pooling liquid in your eyes start streaming down your cheeks, eventually wetting both of your hands. You didn’t even realize that you were already a crying mess as you hollow your cheeks to prevent the pitiful sobs escaping your mouth.

With much fragility, Tooru enclosed your trembling body into a warm hug that instantly melted all the pain you’ve been feeling. You could hear your hearts beating together against each other’s chest.

“It’s okay. We’re okay now. I finally found you again. I love you so damn much, Y/N.” he whispered in your ear, right hand caressing your back.

After a few minutes of staying in that position, you finally calmed your hurricane. You pulled away, greeting his worried eyes with your puffy and red ones. Upon meeting his gaze, you felt your heart soften as Tooru’s caramel ones penetrated in yours. His lips formed into a small smile when he saw the way you looked at him.

He will never forget those doe eyes of yours. The very first time he saw your eyes, he instantly fell in love and he knows deep inside that he’ll keep on falling in love with you in every chance he gets. In every universe and in every lifetime, his heart only belongs solely to you.

Your faces acted on their own, slowly moving towards each other until your warm lips clasped with each other. The tension that was middling the two of you finally broke today. It started gentle, lips moving together in sync not until Tooru’s hand grabbed your jaw, lightly turning your face to the side to deepen the kiss as he explored the cave of your mouth that he hasn’t tasted for years.

You pushed yourself above him, finally straddling his lap and wrapping both of your arms around his neck as the innocent kiss suddenly turned into a heated one. Tooru would lie if he said that he didn’t miss all of this. The feeling of being intimate with someone that he hasn't given a chance after your break up because he doesn’t want to do this thing if it’s not with you.

Grinding yourself against him, you felt the growing bulge that was now poking your heated core. You couldn’t help but to let out a soft moan that made Tooru halt his action. It turned him on.

“Y/N, do you want to do this?” he asked, eyes now filled with lust. You nodded, wiping the corner of your mouth. You could feel your cheeks firing up as embarrassment crept in your soul for wanting him.

“Words, love. I need your consensual words.” he commanded you.

Despite the awkwardness you’re feeling, you couldn’t help yourself especially when you felt him fully erected under you. “Y-yes, Let’s do this.”

That’s all it takes for Tooru to gently place you in the bed and continue kissing your unattended mouth. His hands started roaming around your breasts, squeezing both of it tenderly that earned another moan from you. You felt him smirking against the kiss before he humped above you, aligning his clothed bulge that was restraining against his jeans and rubbing it against your clothed pussy.

It ignited a pool of wetness as you felt the hardness being rubbed in you.

“H-hgggh…Shit,” you cursed, eyes shutting from the luscious friction.

“Fuck, Y/N. I’m so hard for you.” Tooru said as he massaged your core with his hand. He felt the wetness leaking from your clothes that made him bite his lip in horniness.

He went down from his position as he pulled the hem of your scrub suits down, completely removing your bottom garment that revealed your wet panties. Tooru mentally cursed at his view. All he did was kiss and teased you and yet, you’re already a pooling mess for him. The way how your body reacts to you is driving him insane.

Slender fingers started circling around your clothed core that sent a jolt of pleasure in your body, making your back arch. Tugging the only piece of your bottoms down, he successfully removed the clothing swiftly. He was welcomed with your dripping pussy for him. He didn’t waste another second and devoured it hungrily, tongue nibbling your clit.

“Ahh!” you let out a loud moan as his warm muscle made contact with your pussy. He was licking and placing soft kisses before alternating it with sharp circles by his tongue. The way he glides his mouth against it was driving you in nuts, almost making you see stars.

“Shit shit Tooru, it feels so good!” you did hesitate to let out another moan when he inserted a finger inside you. When he felt that your walls adjusted to it, he slid another one before moving his digits in and out.

You don’t know what to feel due to the intense pleasure that was being thrown at you when he started scissoring his fingers inside. You felt like you could cum with just his fingers. Tooru’s eyes never left your sight and watched how you’re taking his fingers really good.

“F-fuck, Tooru. Please! I want you…Fuck me! I want to come in your dick,” you pleaded messily as you felt your stomach being tied in knots.

With that, he took his fingers out and started stripping his bottoms. His aching hardened cock finally freed itself and slapped against his abdomen. This wasn’t the first time that you saw Tooru naked and this wasn’t definitely the first time that you saw his member but shit, its length and size never fails to amaze you.

Quickly grabbing his wallet, he took out a piece of rubber which you quickly recognized.

“You really took the condoms earlier?” you asked, eyeing at the packet of condom that is now being torn from its packaging.

“Just a few pieces. For emergency.” he grinned as he slid the rubber on his dick without any problem. You laughed as you already expected that from him.

Positioning himself between your legs, he grabbed the shaft and started rubbing the tip against your pussy, almost teasing you. The damn idiot was smirking the whole time and slammed his dick inside you that made you yelp.

“Fuck! Tooru, what the hell?!”

“You like it rough, don’t you?”

He started rocking his hips slowly before picking a consistent pace that made him groan in pleasure.

“You’re so fucking tight and wet, Y/N. Fuck love, I love you and your pussy so much.” he said in between the thrust like he’s worshiping your whole self. You let out a chuckle that was replaced with erotic sounds as he started thrusting in a much faster pace. You felt your walls being stretched out but at the same time, it felt so good that his dick’s the one who’s stretching you out. Tooru found your g-spot in between the thrust that earned you a loud moan as the waves of electricity slammed your body.

“Yes! There! I-it’s so good! Y-you’re so good!” you moaned out as the same spot was abused by his dick repeatedly.

You felt that he’s nearing because his thrust became incredibly faster and impatient. His face was now grunting as beads of sweat rolled down his forehead, lips parted in pleasure. Your stomach starts hardening as your core feels like it’s going to combust anytime. Your insides are tightening so much, indicating that you’re also nearing.

“T-tooru, M’gonna c-cum,”

“Me too, love. Me too.”

He replied incoherently, thrusting a few times more before pulling his member out, coming inside the piece of latex. You also released the coil that is forming inside you before he could even pull his dick out.

The both of you were panting so hard with your legs trembling and chest heaving. Tooru collapses on your top with a smile, kissing your lips once more before burying his face on your neck.

“I love you, Y/N.” he said, which made you let out a genuine smile.

Meanwhile, across the wooden door of the master’s bedroom, Tobio was standing with two cups of your favorite 3-in-1 iced coffee that was meant for you and him, right hand completely frozen on the doorknob’s surface as he listened to the alternating erotic moans launching from each other’s mouth while making love.

© lightaflaem. do not repost on any platform.

[birdyverdie]

Hiya! Just wanted to drop by and say hi and thanks for reaching out and saying hi on my silly little post about talking about DD :,)

I love seeing all the Paracelsus enjoyers, she is the best shrimp posture doctor. <3 Do you have any personal favourite/niche headcanons for her?

Also good luck with your exams! Are you studying medicine/biomedicine? (I did a few classes a few years ago, and kudos -- it's so much material, especially the anatomy classes.) Do you have a favourite class? :o

Hi hi! :D! I put the personal stuff under a read more because by GOD can I ramble </3

Of course! I always like saying hi to people I see in the Darkest Dungeon tag! I think your art is SO lovely too!! I adore the way you draw Dismas and Reynauld!! They're so shapely in your style <3 pair that up with a Bloodborne crossover?? you're spoiling us fans fr!!

I'm a Para enjoyer first and foremost because I relate with the thirst for random medical knowledge that Para has, and also her bird motif!! (She's bird-like in my heart and soul. And I'm a bird enjoyer <3)

I have a few stray headcanons for her, mostly everything is about her scope of practice because that's where my thought process tends to stray when I study. We know that she's named after the father of toxicology, so most of her study goes into figuring out external agents effects on the human body. Though, I like to imagine her to have side interest in hematology as well! Mixing blood with a bunch of other agents seems like something she would be interested at least. (Perhaps that's how she finds out about blood types...*cough* I've been thinking about writing a Paracelsus fic about this for literal months *cough*)

This is a personal thing of mine, but I refuse to believe that Paracelsus actually believed in Humorism. I mean, the first iteration of it was basically a glorified personality test, nay horoscopes! (Yes I know that knowledge was limited back then, but alas, I'd like to imagine her scope is more experimental than observational.)

So instead I headcanon her to--if not the progenitor of Germ Theory--then at least a constituent of it. I think she and Louis Pasteur would have really fun conversations about it.

Another stray headcanon I have is that she receives the equivalent of a newspaper subscription from historical medical practitioners/researchers. So her daily newspaper could be about Edward Jenner's vaccine studies or Ferdinand Cohn's endospores. I don't care that the two of them existed 100 years apart, if we can have a 7th century BC Roman Vestal and a 14th century Plague Doctor in the same room then I can have Edward Jenner and Andrew Wakefield ("vaccines cause autism" guy) duking it out in scientific papers that Paracelsus reads like a WWE match.

Thank you for the luck fellow science enjoyer! Are you also studying medicine :0!?

Thankfully, my exam period is finally over, so I'm taking it easy with recuperating with the post-exam burnout :P And I'm a health major with a nutrition minor, but with a program path towards perfusion! My far-future end goal is to become a surgeon, but due to life circumstances I'll have to settle for perfusion for the time being :P Which I don't mind at all! I think it's such an interesting field, and a hidden hero for many cardiac surgeries! I also really like learning about the circulatory system so I think it's a little perfect ehehe :D!

My favorite class is currently Anatomy & Physiology, I have a really good professor this year, but my god It's actually a lot more complex than I thought it was gonna be while walking in. I genuinely thought it was mostly memorizing like...the bones of the skeleton and perhaps the muscles or something like that. Nahhh it takes a lot of micrology concepts too ;; Which I don't mind! But some days I'm staring at some topics like the neuromuscular junction and wishing I never knew what acetylcholine was. Though some days I do wish to return to Medical Terminology, that class was what I imagined: simple.

Thank you so much for this ask!! It was lovely talking about it!!

[darkmaga-returns]

Originally posted Jan 2023.

The medical community and the media hang their hats on the use of ‘double-blind, placebo-controlled, peer-reviewed studies published in legacy journals such as The New England Journal of Medicine (NEJM) and the Journal of the American Medical Association (JAMA). In a future substack, I will go into detail about the fallacies, and even the scam, of peer review and why it should not be held out as sacrosanct.  

For today’s discussion, let’s examine why all vaccine research should be questioned. Yes, ALL of it. If you read enough studies, you’ll see the patterns described below. For this substack, I’ll use this study on the safety of hepatitis B vaccination in children in India as an example. The vaccine used, Revac-B, contained both 0.5mg of aluminum and 0.05 mg of thimerosal, considered to be safe.

1. Vaccine trials can be quite small and include only healthy children.

Every study begins with ‘selection criteria’ that describe including only healthy individuals. This is from the hepatitis B study example:

All 60 subjects included in the study were in good health and had a negative history of hematological, renal, hepatic, or allergic diseases. All were screened and found to have normal blood panels, including normal liver enzymes.

When a vaccine trial has been completed and the vaccine is approved for use by the FDA, the vaccine is recommended for ALL children, regardless of their health condition, family history, or genetics. In fact, the new shot is most ardently pushed on children with underlying health concerns, such as seizure disorders, cardiac anomalies, and conditions such as cystic fibrosis or Down’s syndrome. These children become the next round of experimentation because the vaccines were never tested for safety on these groups and others.

2.  Vaccine studies follow side effects for a short period of time.

Most clinical trials monitor for side effects for a paltry 21 days, often less. In some studies, such as in the example we are using, children were monitored for 5 days by study monitors and 5 days by cards given to parents. If no reactions occur, the shot is deemed to be ‘safe.’

However, it can take weeks to months for immune and neurological complications to appear. These arbitrary deadlines, allowed by the FDA, prohibit making the connection between vaccines with chronic health disorders. If an illness emerges later, of course, the doctors will say it has nothing to do with the vaccine.

3.  Most vaccine safety studies do not use a true placebo.

The gold standard in medical research is the "placebo-controlled" trial. A placebo is an inactive or inert substance, such as a sugar pill or a shot of saline. In the trial, the placebo is given to one group, while the treatment group is given the experimental product. The placebo arm is used to ‘blind’ the study so the investigator doesn’t know if the subject received the Real Thing or the Inert Substance to minimize interpretation bias.

When reading a published vaccine trial, the substance used as the placebo is often not identified; it is simply called ‘placebo.’ For example, in this study for a new hepatitis B vaccine to treat chronic hepatitis B, the word ‘placebo’ is used 22 times, but we don’t know what placebo was used.

And that’s a problem. The substance used as a ‘placebo’ is often not inert; it may even may be another vaccine. For example, I remember reading a study where the meningitis C vaccine was used as a placebo because it was considered to be non-immunogenic and non-reactive. Or, in the instance of the Gardasil (HPV) vaccine, the ‘placebo’ was an injection of aluminum.

All studies for the Gardasil vaccine were said to be placebo-controlled and the total population that received a placebo included 9,701 subjects. The placebo was an aluminum adjuvant in all studies except study 018 (pre-/adolescent safety study), which used a non-aluminum-containing placebo [and we don’t know what that placebo was]

[lamarworld148]

Pathology & Microbiology

Department of Pathology & Microbiology

S. N. Super Speciality Hospital offers in-house, state-of-the-art laboratory services designed to meet patients’ needs with the highest level of integrity. Our Clinical Laboratory operates 24×7, providing unwavering support to our medical teams across the hospital, ensuring timely and accurate results in all cases. At S. N. Super Speciality Hospital, we hold the principle that quality isn’t accidental; it is achieved through focused intention, sincere effort, informed guidance, and skilled execution. The Pathology Laboratory, dedicated to delivering quality care as an emergencies hospital, is equipped to handle critical cases promptly, recognizing that catching the right ‘pulse’ within tight ‘deadlines’ is vital to effective recovery.

Dr. Kamal Preet (Pathologist)

Our hospital is proud of its advanced and unique medical lab facilities, featuring world- class instruments and highly-trained, efficient staff. This enables S. N. Super Speciality Hospital to go to the ‘heart’ of each test and research task, providing 24/7 services with precision, particularly as an emergencies hospital. Our clinical laboratory stands as one of the best blood testing facilities, embracing the philosophy that time waits for no one, especially in critical health matters.

S. N. Super Speciality Hospital also provides an extensive scope of services, including immunology, biochemistry, hematology, clinical pathology, serology, and microbiology. These services are supported by a wide range of advanced automated analyzers, enabling our medical lab technicians to deliver reliable results round-the-clock. We are committed to providing our patients with seamless, quality laboratory support whenever emergencies arise, reinforcing our commitment to excellence in healthcare.

In summary, our clinical laboratory embodies a dedicated commitment to supporting the hospital’s medical teams with superior diagnostic capabilities, particularly during emergencies.

[beepingmemesauce2727]

Plans for future Spidey-Villains if I were in charge of continuing The Spectacular Spider-Man.

Mac Gargan / Scorpion:

• Private Investigator hired by J. Jonah Jameson, like in the comics

• Fails due to Peter using his spider-sense to evade him, leading to him being fired by Jameson, which not only causes him to lose his job, but also leaves him homeless, but is offered a second chance by a man claiming to work for The Kingpin

• Registers for an experimental operation by Wilson Fisk and Alastair Smythe, the idea behind the operation being to essentially create a genetically-enhanced police officer

• He is injected with multiple steroids that enhance his physical strength, and his outfitted with bulletproof armor equipped with a cybernetic tail

• Same story as in the comics basically, he is sent to capture Spider-Man, but over time, the chemical augmentations start affecting his brain and drive him to insanity, leading him to paralyze Smythe, and attack J.J.J., Peter promptly defeats him

• Eventually joins a new version of the Sinister Six

Roderick Kingsley / Hobgoblin

• Perfume company CEO, wants to buy Oscorp, but Harry doesn't like him as he thinks Oscorp is the "Osborn Family Legacy", Roderick doesn't like Harry either, seeing him as a nepo baby, (which Harry kind of is)

• Has a twin-brother named Daniel, but is less successful than Roderick, leading to constant belittling by his older brother

• Secretly does shady business deals, like in Season 2 where he attended the auction with NYC's various crime lords

• Hires a spy to infiltrate Oscorp one night, that thug discovers the Green Goblin's tech, spy steals it and brings it back to Roderick

• Roderick sees an opportunity, and creates a new persona, The Hobgoblin, and learns that Osborn used performance-enhancers to gain his superhuman powers

• Creates a chemical compound that includes all of the effects of the original Globulin Green with none of the side-effects

• Roderick decides he can frame other people as the Hobgoblin so he can get away with his crimes scott-free and take control of Oscorp and expand his business

• Multiple people are framed for being the Hobgoblin throughout the third season, including Ned Leeds, Harry Osborn, Emily Osborn, J. Jonah Jameson, and even Roderick's own brother Daniel

• Enters a turf war with Wilson Fisk

• Eventually, Roderick is outed as the Hobgoblin, and is imprisoned

Art by TheJikaruss on Deviantart

Micheal Morbius / Morbius the Living Vampire

• Born in Greece in 1939, raised in America

• Was raised by his single mother, his father left his mother before he was born

• His mother died of a rare illness which caused her blood cells to rapidly degenerate, and eventually, Michael develops this disorder as well

• He meets Emil Nikos, and they become best friends, Nikos finds out about Michael's condition and vows to help him create a cure

• They won a Nobel Prize for their achievements in hematological research, and used the money to conduct the experiment that would cure Michael of his condition in 1971

• The experiment involved injecting Michael with a serum derived from the DNA of vampire bats, and electroshock therapy to enhance Michael's mutated blood cells

• The experiment goes awry, and Michael is transformed into a hideous creature resembling a vampire

• Michael kills Nikos in a bloodthirsty rage, and only regains his senses when he has completely drained Nikos of his blood

• Wracked with immeasurable guilt, Michael attempts suicide, but saves himself as living is a habit

• He roams the world for decades, eventually stumbling upon the house of Curt and Martha Connors, who he attacks while Peter is on a school field trip to the Florida Everglades

Morris Bench / Hydro-Man

• Demolitions expert, as he is in the show

• His wife divorced him a few months prior to the series, so he's a bit depressed

• He is brought to an experiment taking place on a cargo ship overseen by Oscorp, where there are experimenting with a device that can filter out hazardous chemicals in the world's various oceans

• The ship is attacked by the Hobgoblin, who is trying to steal technology, a fight breaks out between Spider-Man and Hobgoblin, and in the scuffle, Morris is knocked overboard

• Morris' body reacts strangely to the generator's radioactive materials, which causes his body to break down and then reform itself into a body that can transform itself into living water

• Hydro-Man escapes the hospital he was held in, and runs into the Hobgoblin, who convinces Morris that Spider-Man is responsible for his condition, and Hydro-Man swears revenge against the web-slinger

• He battles Spider-Man, who defeats him by freezing him with liquid nitrogen, and handing him over to the NYPD

• He is imprisoned, but eventually thawed out to join a new version of the Sinister Six

Cletus Kasady / Carnage

• Cletus is revealed to be a serial killer like in the comics

• He was born to Roscoe and Louise Kasady, and after he tortured and killed his mother's dog, he was sent to the St. Estes Home for Unwanted Children

• After he burned down the orphanage and killed the staff and its students, he murdered his parents as revenge for locking him up in that hell-hole

• He went on to murder several more people, until he was arrested, where the judge labeled him insane and had Cletus sent to the Ravencroft Institute for the Criminally Insane, where he "befriended" Eddie Brock

• After the Venom Symbiote returns to Eddie in his and Cletus' cell, Eddie turns into Venom and causes a break out

• Little did Eddie know, the symbiote had produced an offspring, and it bonded to Cletus' bloodstream, turning the symbiote red and giving it full control over Kasady's cellular structure, making him much stronger than Eddie and Venom

• Cletus became Carnage, and resumed his killing spree, but on a mass scale, turning anyone in his way into his symbiote possessed minions

• Spider-Man realizes he has no choice but to team up with Venom. He also joins up with Black Cat, Cloak & Dagger, Morbius, Sandman, Prowler, and Silver Sable to take down Carnage and his drones

• Carnage is eventually defeated, and the symbiote hordes are returned to normal

• Cletus is imprisoned by S.H.I.E.L.D., due to the catastrophic event he just caused, and that's the last we ever see of Carnage

• Or is it?

Hobie Brown / Prowler

• He becomes friends with Peter in Season 3

• He has a bone to pick with Harry Osborn due to his doping in Season 2

• However, his girlfriend Mindy McPherson is kidnapped by the Hobgoblin's men, and he takes matters into his own hands

• He dons the Prowler suit for the first time, and takes out mutiple caches of Hobgoblin's goons throughout the city in order to get to Mindy

• He runs into Spider-Man, and they get into a disagreement on how to take down The Hobgoblin, Peter just wants to simply defeat Hobgoblin and bring him to justice, whereas Hobie wants to kill Hobgoblin, and they get into a fight

• They eventually stop fighting, and put their differences aside to save Mindy

• They defeat Hobgoblin and his men and save Mindy, but Hobgoblin escapes before he can be arrested

• Prowler eventually teams up with Spidey again during the "Maximum Carnage" event

John Jameson / Man-Wolf

• Still in Ravencroft after Season 2

• He's still obsessed with the strength he obtained during his time as Colonel Jupiter

• He is visited in his cell by J.J.J. and Miles Warren, who offers to give him back the power he so desperately wants

• He is injected with a steroid that turns him back into Colonel Jupiter, and he becomes an ally to Spider-Man again

• Warren secretly installed nanites into John's bloodstream that would activate under lunar rays

• During one night out on patrol, John keeled over in pain and transformed into a hulking canine creature dubbed The Man-Wolf

• Man-Wolf eventually attacked his father at the DB, but Spider-Man used an antidote on John that eliminated the nanites in his system and turned him back into a human

• John was eventually turned back into Man-Wolf, and kidnapped by Kraven the Hunter and forced to fight Spider-Man again during this show's adaptation of "Kraven's Last Hunt", (Man-Wolf takes the place of Vermin) but after Kraven dies, Spider-Man goes after Man-Wolf and turns him back into a human again

• Warren finds a strand of Man-Wolf's hair, and keeps it along with a sample of Globulin Green...for safe keeping

Prof. Miles Warren / Jackal

• He's taken Dr. Connors' place as ESU's science division

• He has an assistant named Debra Whitman

• He was behind Molten Man and Man-Wolf, and will be the ultimate mastermind behind the Clone Saga

• He creates a clone of Peter and Gwen, the Peter clone is used to tarnish Peter's reputation as Spider-Man, while the Gwen clone would become Miles' surrogate daughter

• Miles' wife and daughter died prior to the series in an accident, and Gwen reminded him of his daughter

• So that when she died, Miles had a mental breakdown and decided to use his expertise in cellular biology to create a perfect clone of Gwen

• But Peter and his clone eventually put aside their differences, and confronted Miles in the ESU lab

• As a last resort, he injected himself with a serum comprised of canine DNA and Norman Osborn's Goblin serum, turning him into a monster called The Jackal

• He's eventually defeated, imprisoned, and returned to his human form after a vicious fight with Peter Parker and Ben Reilly

• He later escapes prison and creates a newer, stronger clone he calls Kaine, he brainwashes Kaine and sends him after Peter and Ben

• Kaine is eventually freed from his brainwashing and kills Miles for all the people he's hurt, Peter, Gwen, Curt Connors and his family, Mark Allan, and John Jameson

Art by Lunamidnight1998 on Deviantart

Martin Li / Mr. Negative

• Was experimented on by Wilson Fisk's head scientist, Dr. Jonathan Ohnn, and was imbued with Light & Darkforce powers

• Runs a soup kitchen with Aunt May and Nathan Lubensky called F.E.A.S.T.

• Secretly a crime lord called Mr. Negative and forms a group called the Inner Demons

• The experiments by Dr. Ohnn also created Cloak & Dagger

• Becomes the third wheel in The Kingpin and Hobgoblin's Turf War

• Eventually depowered and redeemed

Thank you for reading! :)

[research-duck]

V-3623

Ive never been an epidemiologist, however with one of my specialties being Hematology I’m often assigned to test subjects with the V prefix. Normally the acquisition of a V class preternormal entity means ill be preforming an autopsy, blood tests, or some other post mortem testing… vampires dont get captured often.

This is seemingly because the OSC at large has an ongoing deal with the Fanged Court of Amity City, some sort of vampire government. If the Sanguine keep out of the public eye theyre allowed to do as they please… the ones who dont mind the rules are hunted down.

However V-3623 #138 was a special case. We had caught him before the disease had even finished incubating. The office was in a frenzy as teams were put together to observe the infection, death, and undeath of this man. I was volunteered to observe as my education made me uniquely qualified.

Through the window I saw a young man, with shaggy chestnut hair and pale skin. He had a wound on his neck, rapidly soaking a bandage. I asked a senior researcher why we werent stitching the wound but was only hushed in return.

After 2 minutes of observation he rapidly collapsed. The Cholcadonia - V virus had finally finished incubating and was starting its next phase. Suddenly researchers rushed into the room, attaching the boy to an EKG, drawing his blood, setting up a number of monitoring devices. His heart rate was at 32 BPM, his body temperature was slowly rising, his body sat so still…

This is known as Cholcadic Coma, and once all the machines were set up we sat and observed.

The first thing I noticed was his brain scan. It lit up like a forest fire and i watched as the brain began to shift and warp, the Amygdala changing in size and shape. The cameras focused on the eyes showed the pupils and sclera began to flood with blood and suddenly the blood pressure rapidly dropped. A camera focused on the teeth showed as certain teeth, the top canines and some in the bottom row began to rapidly rot at the roots only to be replaced by erupting fangs.

His muscles began to swell and change, it seemed as though fibers were tearing and reconnecting instantly with higher twitch muscles.

Then suddenly he died. Flat line.

We sat in silence as he lay unmoving for hours… when suddenly he sat up.

[bisque-firedvampire]

Head canons for Multimedia Morbs 2:

Embarrassing stories:

TAS: he once mentioned the whole “turned into a giant bat to hibernate/fall into a coma for a few months “ thing once. most wanted more details, and some were very skeptical even after the details. He still remembers it as some of the best sleep he’s ever had (he is a college student after all).

Ultimate: knows a scary amount about symbiote/Klyntar biology because that was his field of study at hydra (not phlebotomy or hematology, which the others find weird); which brings up the question “how did your accident happen, then?”. He doges the question every time because he’s embarrassed to admit that he didn’t do it himself (Otto did it to him as payback for his attempted backstabbing and betrayal). Therefore the rest of them come up with wild “theories” about it (both to tease him and also to get him to tell them what actually happened; this was either TAS or Midnight Son’s idea).

616: has mild claustrophobia from being held hostage in boxes/containers for indefinite periods, on multiple occasions, by bad guys. Tries his best to hide it from the others, especially Ultimate (the last couple of times where because of unethical scientists, and if that isn’t Ultimate…). Also, he modeled for a swimsuit issue and a sunscreen ad once; regrets the later but not the former.

Blood ties: has a favorite soap opera that Amanda got him into while they stayed in hotels during their cross country journey; it’s a rough expy of both ‘Dark Shadows’ and ‘The Young and The Restless’. 616 remembers the show too, but doesn’t actually recall enjoying.

Midnight Son: occasionally enjoys scented candles and meditation; the others immediately played up his enjoyment of them after hearing about it (a lot of them have a really sensitive sense of smell and just can’t stand candles anymore). Surprisingly, when no one else can verify it, Ultimate is very thoughtful about the candles and will leave him new unused ones (he can tolerate the smells and knows that they bug the others; it’s not be nice or anything…).

Movie: once admitted that he went to ‘a school for gifted children’ in upstate New York, and everyone assumed he meant Xavier’s school; some people were nicer about that others. It actually was just a regular school, but having been told about the X-men, he’s not in a hurry to correct anyone.

Work Experience:

TAS: is just a graduate student, but has taught an elective class or two; he has yet to TA for any of his professors. Had gotten job offers from Oscorp for after school, though. Not that he can still apply since his accident… Does hunting vampires across Europe with Blade count?

Ultimate: was immediately head hunted directly from college by Hydra, and has never worked anywhere else (not sure if he can work anywhere else; either because of the reference or because of disapproval from his father). Working with Octavius was supposed to be a stepping stone/ big break towards moving higher up, if he hadn’t bungled it.

616: has always been in medical research, who funded it has changed over the years, though: was self employed, was hired by the west coast Avengers, then the Fantastic Four, worked at st.Jude’s hospital for a bit, was part of Shield medical division for a bit, then was at Horizon Labs under a pseudonym, was used in research by Beyond corporation, and is currently self employed, again…

Blood ties: other that his own research, he’s never really had a job, does he qualify as a personal investigator for helping Amanda track down her parents?

Midnight Son: mostly independent research, that’s about it.

Movie: works at Horizon labs In medical research, but not anymore of course.

What else would you ask them?

[chiss-ticism]

for the Sabbat OCs of your choice: 29, 35, 46, and 48? :3

tysm!!!

dividers by @/marquisedegramont

🎨 - Crownedinmarigolds [Ida, Judy, Luther] 🎨 - belthegore [Sir Percival]

Judith "Moody Judy" Margolis: Brujah, Black Hand Remover, Pack Ductus.

Ida Obertus: Tzimisce, Pack Priest, Former Revenant.

Sir Percival: Ventrue Antitribu. Templar. [Black Hand Recruit in New Orleans by Night]

Luther: Lasombra. Caine's silliest little guy.

29.) Do they frequently change locations or do they have a fixed location where they live?

Both! Their communal haven, maintained by two Obertus Revenants whilst the Pack is otherwise occupied with the Dark Father's work, is located in Montreal. It's a unparalleled repository for knowledge - forgotten and mundane. Not that they're advertising that, mind you. When the entire pack is on the move - be it as backup for Judy's Black Hand scheming, or should the Beckoning ever prove too much for Ida to hold off - they typically set up 2 - 3 havens. A dingier one for Judy to maintain the appearance of her Mask - Mina Graham, Anarch, itinerant scholar from Out of Town - and other havens as needed for Ida, Percy, Luther, and the one Revenant they keep with them at all times.

Nestled away in a quiet corner of the manor's expansive libraries lay an alter handcrafted and carved from basalt; an exquisite bas relief, inlaid with gold as it were, depicts a family drinking deeply from goblets. Three men and one woman glut themselves on the bacchanalian feast - thirteen empty chairs wreathing them. Atop the dedicatary lay a simplistic statue of the Dark Father, his head cast downwards: askance from the heavens. At his feet lay offerings from the denizens of the home - the preserved skull of a Tremere (fangs intact), a vial of Ravnos blood, a seemingly nondescript rock (taken from Zillah's place of torpid suspension), several framed fragments Book of Nod - penned delicately atop parchment made of skin, and several (smaller) tributes left by the attending Revenants of the household who - by blood, culture, and history - also claim descendance from Caine. Swaddling the entire thing were bundles upon bundles of meticulously maintained flowers; some were grown in the manor's garden, others still imported directly from the cradle of civilization itself. Crossbred to produce a subtle reminder: venerate what was, appreciate what is, and stride brazenly toward what could be.

35.) How old is your OC up until their death?

Luther: Died at 24 years old. [1784]

Ida: Died at 32 years old. [1884]

Percival: Died at 42 years old. [1942]

Judy: Died at 27 years old. [1952]

46.) What are their ambition(s) if any? Rather generically, loosen the grip of the Antediluvians and their unwitting pawns. When building the Pack from scratch, Margo handpicked each of them for their dedication and worth to the cause. They each contribute in their own way

Ida's eidetic memory, vast library, and personal research into supernatural hematology is invaluable.

Luther is a dedicated Noddist [hence him having the Mark of Caine, a byproduct of a long-forgotten ritae, on his forehead.] who also has an eidetic memory and personal experience with throwing metaphorical rocks at Setites.

Percy is sickeningly earnest in everything he does - making him excellent for outreach. Martial support, too.

On top of her capital E extensive research into the Anarch Revolt/Convention of Thorns, personal experience and research into the modern-night Anarch Movement, as well as tidbits on how the Camarilla functions - Margo has the support of the Black Hand.

48.) Detail things about your OC you spent a lot of time on!

Oh god, I'm honestly not too sure... 🤔... I spend so much time thinking about them that it all just kind of blends together, lmao. Thank you for asking, though!!!!

[expertacademicassignmenthelp]

The Physiology Of The Liver

The liver is a vital organ responsible for numerous functions including metabolism, immunity, digestion, detoxification, and vitamin storage. It weighs around 2% of an adult’s body weight and is unique due to its dual blood supply from the portal vein (75%) and the hepatic artery (25%).

Cellular Structure

The liver’s functional unit is the lobule, which is hexagonal in shape. Each corner of the hexagon has a portal triad consisting of the portal vein, hepatic artery, and bile duct. The lobule is composed mainly of hepatocytes, which have distinct apical and basolateral membranes. Hepatocytes are categorized into three zones based on their function and blood supply:

Zone I (periportal region): Closest to the blood supply, involved in oxidative metabolism (e.g., gluconeogenesis, bile formation).

Zone II (pericentral region): Sits between Zones I and III.

Zone III: Farthest from the blood supply, primarily involved in detoxification and biotransformation.

Blood and bile flow in opposite directions within the liver. The space of Disse, between the hepatocytes and the sinusoidal lumen, contains Kupffer cells (macrophages) and Ito cells (fat-storing stellate cells).

Development

The liver develops from endodermal cells of the foregut as the hepatic diverticulum around the fourth week of embryonic development. It undergoes complex differentiation influenced by various pathways (e.g., Wnt/β-catenin, FGF). By the sixth week, the liver participates in hematopoiesis, and hepatocytes begin bile production by the 12th week.

Organ Systems and Functions

The liver interacts with multiple body systems:

Digestive and Metabolic Roles: Aids in digestion, stores fat-soluble vitamins, and handles cholesterol.

Hematological Functions: Produces clotting factors and proteins.

Detoxification: Metabolizes drugs and other xenobiotics through phase I (oxidation, reduction, hydrolysis) and phase II (conjugation) reactions.

Bilirubin Metabolism: Converts heme to unconjugated bilirubin, then conjugates it for excretion.

Hormonal and Protein Synthesis: Involved in thyroid hormone activation and synthesis of nearly all plasma proteins.

Related Testing

Liver function tests (LFTs), including ALT, AST, bilirubin, alkaline phosphatase, and gamma-glutamyl transpeptidase (GGT), help assess liver health. Imaging techniques like ultrasound, CT, and MRI are also employed to identify liver abnormalities.

Pathophysiology

Cirrhosis results from chronic liver injury (e.g., due to alcoholism, hepatitis B and C), leading to fibrosis and necrosis. It causes symptoms like portal hypertension, coagulopathy, and jaundice. Hepatitis viruses (A, B, C, D, E), autoimmune diseases (e.g., primary biliary cholangitis), and metabolic conditions (e.g., non-alcoholic fatty liver disease) also contribute to liver pathology.

Clinical Significance

Understanding liver physiology helps manage conditions like viral hepatitis, alcoholic liver disease, benign liver lesions, and liver cancers. Early detection through appropriate testing and management strategies is essential for preventing end-stage liver disease and improving patient outcomes

As academic students and researchers navigate the challenges of their assignments and research endeavors, Expert Academic Assignment Help stands ready to provide professional guidance and assistance. Whether you require support with assignment writing, research paper assistance, or essay help, our team of experts is dedicated to helping you achieve academic excellence. Reach out to us today at expertassignment46@gmail.com and let us support you on your academic journey. We wish you success and professional excellence.

[astrumocs]

Good to hear!

If you don't mind me asking, what do you research? What kind of blood do you need for it? :0

"It's nothing personal, but I prefer not to go into too much detail, especially with strangers I don't know the name of."

"I can say, however, that I would consider my work both involving and adjacent to hematology and leave it at that."

^ Julius won't be repeating the secrets that have already been spilled in the past, he's much too paranoid.

^ To clue you in, however, you should know that his work involves changing one's blood color. He was not always a purple blood himself, as it happens.

[the-clock-tiks]

Hematology is re-defined on the analysis of blood's constitutency and nutrition.

While there are more than 22 nutrients in thr blood.

The research says that, there can be other nutrients added into the blood. And what are they??

Nutritional blood analysis can reveal many things.. While the extra nutrients that are added into ghr blood needs to researched.

Blood plasma playing a vital role carrying more water and proteins in it. ( RBC and white blood cell are the carriers of nutrients ) 99 % is the water Constitutency

The blood Contains more rbc n white blood cell to increase the addition or the level of nutrients in the research level of line.

The nutritional analysis of blood says, several statistics of nutrition but addition of extra nutrients in blood isn't discussed nor told yet.

The prp procedure and analysis needs to be taken further. For the research purpose and advancement in hematology n blood nutrients factors n medicine.

Nutrients reducing other important factors for diseases and immuno deficiency and inflammation and generation of WBC.

The nutrition analysis that was made in the hematology. And the blood nutrition analysis with several variations and aspects provides several results in the research and advancement. However clinical trials for the induce of nutrition and other research and analysis is required to produce us the effective results, even under several variations. So in short, the work is at progress