#PTAU

[sugarysketches]

.:Originally made June 20th, 2023:.

Poketrainer AU stuff heehee Toby's a shiny hunter, Beau's just here to have a good time.

[left character uses he/him pronouns, right character uses any pronouns]

[koshimar]

Roberto remembers how to play the guitar.

[im-captain-basch]

How old would be your version of Donkey Kong characters?

A good question, tbh! It's a topic I try to avoid because I jump through a lot of hoops for it. I can give confident answers about the kids for sure, but the non-elderly adults vary a lot since I also mitosis'd/adopted some age headcanons for them from a friend and I've had to scramble to make them work with the kids' age headcanons, especially since I tend to go with human aging instead of actual primate aging as well as for the Pokemon Trainer AU. As a basis, let's go with this for now:

(also I know you said Kongs, but I'm still gonna throw K. Rool in for funsies)

Cranky and Wrinkly: early to mid 70's

K. Rool: early to mid 50's

Junior: early 50's (doesn't age past this range)

DK, Funky, and Candy: early 30's

Swanky: 28/29 to early thirties

Lanky: Late teens/very young adult

Dixie, Diddy, Chunky: 14

Tiny: 11/12

I don't think I'm forgetting anyone, at least unintentionally. There's some fuckery from one month in a year to a month in the next year as well as some actual age gaps with more than one year to consider, but this is the rough guideline I've been following as of late.

[notdrawingwhileasleep]

as mentioned in the tags, the prev artwork was based on a fic my partner wrote, and well,

THEY POSTED THE FIC, EVERYONE GO READ:

Babygirl <3

[bubbytheliverstealingskeleton]

Formulating thoughts about GP au

So bill in this au is much more eldritch horror than his cannon counterpart. Nothing of him is ever seen besides his hands and arms [he also has so many hands it’s his thing in this- many hands and many arms]

So when fiddleford does actually see him he is truly driven to madness and can never really be given his memories back, the best thing is for him to remain without any of his previous memories. Ford never sees Bills form, even after being taken to the Fearamid and imprisoned he only ever catches a glimpse of yellow outside his peripherals, other than that it’s just lots and lots of hands.

I think if bill had tapestries and things made in his image they would be something akin to thousands of limbs wrapped around eachother with a singular eye either caged within the limbs or idk. I don’t think he’d look the same as his cannon counterpart but it would be funny if people were being driven mad from seeing a single tiny triangle.

Alternatively- anything made in his image is still normal bill, maybe with a few more arms, but he’s just. Not that. His form was never anything like that, people just made it up/he made a form for people to worship. Ford I think wouldn’t be surprised at all to find out he’s an eldritch being

Bubb thoughts are over now I had more to say but they escaped me

I did have the thought that it’d be really funny if one of his arms had a bow tie worn on it since he doesn’t have a main body that can be seen

[solarusofsun]

Fake Peppino Friday but I draw the Fake Peppino from my PTAU!

Honestly they're fun to draw

[neocrash1101]

PTAU paint chat...

Sorry for drawing without permission....

@alextydaisuda123

@tv-peppino

@twogaydemons

[hyperfix-wip]

I suck at chemistry bestie 😅

I Want to do a two truths and a lie lie tag game,

1. I never went to college

2. My favorite game is Minecraft

3. I never had my tonsils removed

@zzzubie @somthing-lavender @it-came-from-mount-ebott @codyton @pey-up @itsmiguel2099 @harley-angel @r0tt1ng-bunn1ez @jayden-for-now

[postsofbabel]

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[sugarysketches]

.:Originally made June 22nd-23rd, 2023:.

Two busts done to test different shading brushes ovo)-b

[left character uses she/her pronouns, right character uses he/him]

[covid-safer-hotties]

Proteomics identifies potential immunological drivers of postinfection brain atrophy and cognitive decline - Published Aug 14, 2024

Not covid specific but important to understanding how long covid may is accelerating dementia and other similar brain illness.

Abstract Infections have been associated with the incidence of Alzheimer disease and related dementias, but the mechanisms responsible for these associations remain unclear. Using a multicohort approach, we found that influenza, viral, respiratory, and skin and subcutaneous infections were associated with increased long-term dementia risk. These infections were also associated with region-specific brain volume loss, most commonly in the temporal lobe. We identified 260 out of 942 immunologically relevant proteins in plasma that were differentially expressed in individuals with an infection history. Of the infection-related proteins, 35 predicted volumetric changes in brain regions vulnerable to infection-specific atrophy. Several of these proteins, including PIK3CG, PACSIN2, and PRKCB, were related to cognitive decline and plasma biomarkers of dementia (Aβ42/40, GFAP, NfL, pTau-181). Genetic variants that influenced expression of immunologically relevant infection-related proteins, including ITGB6 and TLR5, predicted brain volume loss. Our findings support the role of infections in dementia risk and identify molecular mediators by which infections may contribute to neurodegeneration.

[koshimar]

Answers to questions for Roberto. [Anthro!AU].

It's time for a more in-depth acquaintance with Anthro!Roberto. This is one of my first and main characters among other AU pizzas. It is on its basis that the characters of other Pizzafaces are created and built.

Some questions are taken from here, and the other part from my Telegram channel. They will appear here alternating with regular publications and with the tag #AskRoberto.

ᅠᅠᅠᅠᅠᅠᅠᅠ ──────── - What was the real turning point that he went from being a little crying child to eventually becoming a big cool rich man who is almost every woman’s dream?

ᅠᅠᅠᅠᅠᅠᅠᅠ ──────── — [!] Translation of the text may be incorrect in some places due to the use of a translator. — [!] Let me remind you that the term "anthro" denotes not only humanoid animals, but also plants, objects, etc…

I wanted to betray Roberto's feelings and what he had to go through as much as possible. I hope I succeeded.

[olympeline]

hello! Sorry to be a bother but I wanna ask if you’d consider continuing your FACE family parent trap AU fic? I just read it and I love the way you wrote the characters! I could picture them actually saying some of this stuff lol. No pressure at all as I know it’s hard to continue stories sometimes, but I’d love to see how this ends! Best wishes either way.

Hey nonny! Glad you like what I wrote. 😚❤️ I’m on a bit of a USUK kick lately so the FrUK and FACE family stuff has taken a backseat. I’ll get back to the PTAU when my interest swings back around to the old OTP :>

[yourreddancer]

New Blood Test Can Detect Alzheimer’s Disease

Alzheimers / Dementia

It’s one of the most feared diagnoses for older Americans: Alzheimer’s disease. Especially for those who have watched a parent or other family member suffer, the prospect of developing Alzheimer’s evokes a sense of dread. There is no cure for the disease, which afflicts nearly seven million people in the United States, including about a third of those over the age of 85. 

However, there are interventions available which can slow the progress of Alzheimer’s. The earlier a patient’s care team can detect Alzheimer’s disease, the sooner these treatments can be offered, and the more effective they are likely to be.

The Current State of Alzheimer’s Testing

Unfortunately, early diagnosis is not common. For a long time, testing has been cumbersome and costly, and only available for people who were already exhibiting problems with thinking and memory. These cognitive signs and symptoms often point to Alzheimer’s, but are not enough for a definitive diagnosis. Up to one-third of patients diagnosed with Alzheimer’s based solely on cognitive symptoms are misdiagnosed. 

It is obviously not a good use of resources to administer therapies for Alzheimer’s disease to patients whose symptoms are caused by other conditions. Accordingly, further testing is usually required before treating patients for Alzheimer’s disease. The point of that testing is to confirm the presence of amyloid plaques in the brain, which are a hallmark of Alzheimer’s. 

The presence of amyloid plaques can be confirmed through a variety of tests, including positron emission tomography (PET) scans of the brain and analysis of cerebrospinal fluid, which requires a spinal tap. Not only are these tests costly (and in the case of a spinal tap, painful), they are only available to those who are already showing some signs of cognitive decline. 

The Significance of a Blood Test for Alzheimer’s Disease

The potential cost, pain, and inaccessibility of the existing tests, paired with the reality that Alzheimer’s is incurable at present, means that many people will put off testing as long as possible. Fear of being diagnosed with an incurable, life-changing disease may outweigh the benefit they expect from available therapies. 

But amyloid plaques don’t just suddenly appear and cause symptoms. Amyloid builds up slowly in the brain over time. There may be up to two decades in which a future Alzheimer’s patient is presymptomatic, and with little or no neurodegeneration. That matters, because while the therapies currently available are helpful, they do not reverse the neuron (nerve cell) loss caused by Alzheimer’s. 

If patients could be diagnosed sooner, they could be treated sooner. That might prevent the loss of brain cells even before the patient is showing signs of the disease or mild cognitive impairment (MCI), often a precursor to Alzheimer’s. (Currently, it is estimated that more than 90% of people with MCI are undiagnosed.) 

A recent research study found that a new blood test for Alzheimer’s disease performs as well as existing FDA-approved spinal fluid tests. Unlike existing tests for Alzheimer’s disease, this simple, non-invasive test can be administered not only to people showing cognitive symptoms of Alzheimer’s, but those who appear healthy. 

Using the Ptau-217 Blood Test to Detect Alzheimer’s Disease

The blood test was developed by researchers at Washington University in St. Louis. The study compared the ability of four tests to identify whether a patient has amyloid in their brain: the ptau-217 blood test, and three existing cerebrospinal fluid tests already approved by the FDA. A total of over 1,750 people were tested; some had cognitive symptoms classified as mild or very mild; others were apparently healthy with no signs of cognitive impairment. 

The results were impressive. The ptau-217 blood test performed just as well at identifying amyloid buildup as the cerebrospinal fluid tests: the accuracy scores for all tests ranged between 95% and 97%. The researchers also measured the accuracy of the four tests in detecting the levels of tau tangles, also found in Alzhemer’s patients, in the brain. In this secondary analysis, the ptau-217 blood test actually outperformed tests using cerebrospinal fluid, with accuracy ranging from 95% to 98%.

What a Blood Test for Alzheimer’s Could Mean for the Future

The expression “time is brain” was coined to refer to the importance of prompt treatment for a stroke. But in a very real sense, it also applies to Alzheimer’s disease. At a minimum, early detection of Alzheimer’s disease can help patients take steps to prevent neuron loss and delay the onset or slow the progression of the disease.

Researchers hope for even greater developments with a blood test for Alzheimer’s disease. Researchers hope to eventually find a way to clear amyloid plaque from the brain, preventing a buildup and the resulting neurodegeneration. Conceivably, presymptomatic patients with a positive ptau-217 blood test could have a regular treatment to clear amyloid every few years, and never develop the disease at all. 

[peridot-the-kitten]

Guys I think the porn bot broke

"Its listette im so czrn and I just really wish you to meet" "begin PTau bebdR quickk i awaitingg youtorrAthere"????? Like gurl are you okay?

[ao3feed-reddie]

Hall Pass

Read it on ao3: https://archiveofourown.org/works/51452425 By: ghstonline by ghstonline Eddie Kaspbrak has been separated from his wife for a year. Although it was his decision, the divorce is still kicking him in the ass, especially in trying to co-parent his teenage son. But, when life kicks you down, there's your son's quirky yet handsome English teacher to pick you back up. Words: 1163, Chapters: 1/?, Language: English Fandoms: IT (Movies - Muschietti), IT - Stephen King Rating: Mature Warnings: Creator Chose Not To Use Archive Warnings Categories: M/M Characters: Eddie Kaspbrak, Richie Tozier, Myra Kaspbrak, Stanley Uris, Bill Denbrough Relationships: Eddie Kaspbrak/Richie Tozier Additional Tags: Alternate Universe - No Pennywise (IT), clown free zone, Alternate Universe - Parent-Teacher, PTAU, AU - Eddie has a son, english teacher richie, parent Eddie, some sex in here at some point, get a little frisky, no label eddie, he's here he's queer, Slice of Life, Old man yaoi, i say old man but they're in their 40s, Divorce