#RNAi Technology

[health-views-updates]

RNAi Technology Market Analysis and Future Scope 2024-2032

The global RNAi Technology Market Size is poised for transformative growth, with new projections estimating its value will rise from USD 3.02 billion in 2024 to USD 9.03 billion by 2032, growing at an impressive CAGR of 14.68% over the forecast period from 2025 to 2032. This remarkable expansion is driven by the increasing application of RNA interference (RNAi) in gene therapy, drug discovery, and precision medicine.

RNA interference, a cellular mechanism that silences specific genes, is playing a crucial role in revolutionizing the biotechnology and pharmaceutical sectors. With the rising global burden of chronic diseases and genetic disorders, there is a mounting demand for innovative therapeutic approaches. RNAi-based therapies are showing immense potential in targeting previously “undruggable” genes, enabling precision medicine approaches that were once considered aspirational.

Emerging Trends Fueling Market Growth

RNAi technology is witnessing a significant surge in research investment, clinical trials, and commercial partnerships. The market is evolving rapidly due to key advancements in delivery systems such as lipid nanoparticles (LNPs) and small interfering RNAs (siRNAs), both critical for targeted gene silencing. The success of RNAi-based drugs like Patisiran for hereditary transthyretin-mediated amyloidosis has paved the way for broader applications across oncology, neurology, and infectious diseases.

Moreover, RNAi’s non-permanent and reversible mechanism of action gives it a competitive edge in safety compared to DNA-based therapies. As pharmaceutical companies continue to seek safer, more targeted treatments, RNAi is emerging as a favored modality, especially in combination with other gene-editing tools like CRISPR.

Key Market Drivers

Rising prevalence of genetic and chronic diseases: RNAi therapies offer hope for patients suffering from conditions with limited treatment options.

Increased R&D spending: Governments and private entities are heavily investing in gene therapy research.

Strategic collaborations: Pharmaceutical giants are entering into alliances with biotech firms to leverage RNAi capabilities.

Regulatory support: Encouraging clinical trial outcomes and regulatory green lights are accelerating market adoption.

Regional Outlook

North America currently leads the RNAi technology landscape, supported by strong research infrastructure, high healthcare spending, and a favorable regulatory environment. The United States remains at the forefront due to the presence of major pharmaceutical companies and academic research institutions. However, the Asia-Pacific region is expected to witness the fastest growth during the forecast period, driven by increasing investments in biotechnology and a growing patient base.

Challenges and Opportunities

Despite its immense promise, RNAi technology faces hurdles related to delivery mechanisms, immune response, and production scalability. However, recent breakthroughs in nanoparticle delivery and synthetic biology are rapidly addressing these challenges. The ongoing integration of AI and machine learning into drug discovery is also accelerating RNAi-based therapeutic development, improving accuracy in gene targeting and reducing time to market.

Competitive Landscape

The RNAi technology market is moderately fragmented, with key players including Alnylam Pharmaceuticals, Arrowhead Pharmaceuticals, Ionis Pharmaceuticals, and Silence Therapeutics leading innovation. Startups and academic spin-offs are also playing a pivotal role, contributing to a dynamic ecosystem that fosters breakthrough discoveries and disruptive advancements.

Future Outlook

Looking ahead, the RNAi technology market is expected to remain a central pillar in the evolution of next-generation therapeutics. As technological innovations continue to overcome existing limitations, and as healthcare systems worldwide adapt to a more personalized approach, RNAi is well-positioned to reshape how diseases are treated at the molecular level.

The road to 2032 presents a promising horizon where RNAi technology could become a mainstay in clinical practice, not just as an alternative, but as a first-line treatment for many complex conditions.

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[mastergarryblogs]

Investor Alert: Why the Gene Silencing Market Could Be the Next Big Thing

Introduction

The global gene silencing market is experiencing unprecedented growth, driven by advancements in genetic research, increasing prevalence of genetic disorders, and the rising adoption of gene-silencing technologies in therapeutics and drug discovery. Valued at approximately USD 3.7 billion in 2024, the gene silencing market is projected to expand at a CAGR of over 17.6% from 2025 to 2032, reaching a valuation exceeding USD 15.9 billion by the end of the forecast period. This rapid expansion is fueled by the increasing demand for RNA interference (RNAi), CRISPR-based therapies, and antisense oligonucleotides (ASOs) for targeted gene modulation.

Breakthroughs in gene-editing tools, AI-driven bioinformatics, and nanoparticle-based delivery systems are accelerating innovation and adoption. The use of gene silencing in treating cancer, neurological disorders, and rare genetic diseases, alongside the expansion of personalized medicine and cell and gene therapy applications, continues to strengthen market growth. Additionally, strategic partnerships between biotech firms, pharmaceutical companies, and research institutions are propelling advancements in gene-based therapies.

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Gene Silencing Market Dynamics

Key Drivers

Growing Adoption of Gene Silencing in Therapeutics

Increasing application of RNAi, CRISPR-Cas9, and ASOs in gene therapy.

Expansion of precision medicine initiatives leveraging gene silencing for personalized treatment.

Rising Prevalence of Genetic Disorders and Cancer

Escalating demand for innovative treatments for hereditary diseases, cancer, and neurodegenerative disorders.

Emerging gene silencing applications in rare genetic conditions and metabolic disorders.

Advancements in Gene-Editing Technologies

Enhancements in CRISPR-Cas systems for precise genetic modifications.

AI-driven bioinformatics for target identification and therapeutic development.

Strategic Collaborations and Investments in R&D

Increased funding for gene therapy research from public and private sectors.

Expansion of contract research organizations (CROs) and biotech partnerships.

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Gene Silencing Market Challenges

Regulatory and Ethical Constraints

Stringent guidelines governing gene-editing technologies.

Ethical concerns regarding genetic modifications and long-term effects.

Complexities in Gene Delivery Mechanisms

Challenges associated with targeted delivery and minimizing off-target effects.

Development of safe and efficient non-viral and nanoparticle-based delivery systems.

Gene Silencing Market Segmentation

By Technology

RNA Interference (RNAi) – Dominating with a 45.6% gene silencing market share in 2024, growing at a CAGR of 18.4%.

CRISPR-Cas9 – Fastest-growing segment at a CAGR of 21.2%.

Antisense Oligonucleotides (ASOs) – Significant adoption in genetic therapeutics.

DNA Methylation-Based Silencing – Emerging applications in epigenetic modifications.

By Delivery Method

Nanoparticle-Based Delivery – Leading with a 42.7% market share, growing at 19.6% CAGR.

Viral Vector-Based Delivery – Expanding at a CAGR of 18.9%.

Electroporation & Physical Delivery Methods – Increasing adoption in clinical applications.

Chemical Delivery Methods – Advancements in stability and efficacy.

By Disease Type

Cancer – Leading with a 38.9% market share, projected to grow at a CAGR of 19.7%.

Neurodegenerative Diseases – Fastest-growing at a CAGR of 20.3%.

Hereditary and Infectious Diseases – Expanding clinical applications.

Cardiovascular Diseases and Others – Rising demand for novel gene therapies.

By Application

Therapeutics – Dominating with a 60.4% market share, growing at 19.9% CAGR.

Research & Development – Expanding as biotech firms invest in preclinical research.

By End-User

Biotechnology & Pharmaceutical Companies – Holding a 48.7% market share, growing at 18.8% CAGR.

Academic & Research Institutes – Increasing focus on CRISPR-based studies.

Contract Research Organizations (CROs) – Expanding service offerings.

Hospitals & Diagnostic Centers – Rising adoption of gene silencing diagnostics.

By Region

North America – Leading with a 46.2% market share, fueled by R&D investments and regulatory approvals.

Asia Pacific – Fastest-growing at a CAGR of 20.8%, driven by biotech innovations in China, Japan, and India.

Europe, South America, and Middle East & Africa – Steady market expansion.

Competitive Landscape

Key industry players include:

Alnylam Pharmaceuticals – Expanding RNAi-based therapeutic portfolio.

Benitec Biopharma Inc. – Partnering for next-generation RNAi therapies.

Phio Pharmaceuticals – Advancing RNAi-based cancer immunotherapy.

Avidity Biosciences, Riboxx GmbH, Integrated DNA Technologies (IDT), Dyne Therapeutics, Bit Bio, Comanche Biopharma, Thermo Electron Corporation, Temasek Life Sciences Laboratory Ltd., WuXi AppTec – Innovating in RNA-based therapeutics and strategic collaborations.

Emerging Trends and Future Outlook

Key Gene Silencing Market Trends

Expansion of Personalized Gene Therapies – Advancements in tailored treatments based on genetic profiling.

AI-Driven Drug Discovery – Integration of machine learning for gene target identification.

Development of Non-Viral Delivery Methods – Enhancing safety and efficiency.

CRISPR-Based Diagnostics and Therapeutics – Rapidly evolving applications in precision medicine.

Blockchain for Genetic Data Security – Addressing concerns related to data privacy and patient confidentiality.

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Future Projections

With continued advancements in genetic research, evolving regulatory frameworks, and increasing global investments in genomic medicine, the gene silencing market is set for sustained expansion. Companies investing in breakthrough RNA-based therapeutics, innovative gene-editing tools, and AI-driven bioinformatics will lead the next phase of growth. As clinical trial success rates improve and new partnerships emerge, gene silencing technologies will play an integral role in reshaping the future of medicine.

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[market-trends-bykr]

Vutrisiran and Acoramidis Redefine ATTR-CM Treatment Options

The Transthyretin Amyloid Cardiomyopathy (ATTR-CM) market is experiencing transformative growth, led by next-generation therapeutics, increasing diagnosis rates, and strong regulatory momentum. Once considered underdiagnosed and undertreated, ATTR-CM is now at the center of groundbreaking drug innovations that are expanding access and improving outcomes.

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Market Size & Growth Projections

The ATTR-CM treatment market was estimated at around USD 10.36 billion in 2024 and is expected to grow to more than USD 35 billion by 2029. Forecasts suggest an annual growth rate exceeding 28%, with some estimates reaching over USD 20 billion by 2033. Increasing patient awareness, expanding screening efforts, and new FDA approvals are accelerating this growth across both hereditary and wild-type ATTR-CM subtypes.

Core Market Drivers

1. Rising Global Aging Population ATTR-CM predominantly affects individuals over 60, with cases increasing due to longer life expectancies and improved diagnostic imaging. As a result, detection is becoming more routine in cardiology settings, especially in developed markets like the U.S. and Japan.

2. Breakthrough Therapeutics: Stabilizers & RNAi Drugs Tafamidis (Pfizer) remains a key player in the market. However, recent approvals of Acoramidis (BridgeBio Pharma) and Vutrisiran (Alnylam Pharmaceuticals) have introduced competitive therapies with improved efficacy, affordability, and administration profiles. Vutrisiran, an RNAi-based therapy, has shown up to 30% reduction in mortality and major cardiovascular events in clinical trials.

3. Enhanced Regulatory Pathways ATTR-CM therapeutics have benefited from orphan drug designations and fast-track reviews in the U.S., EU, and Japan. This has accelerated the clinical pipeline and led to quicker patient access, especially in cases involving life-threatening cardiac amyloidosis.

4. Technological Advancements in Diagnosis Improved cardiac imaging (echocardiography, nuclear scans, and MRI) and biomarker screening are boosting early diagnosis and making patients eligible for treatment before severe heart failure occurs.

5. Pipeline Maturity and Biotech Collaborations The ATTR-CM pipeline is rich with antisense oligonucleotides, small interfering RNAs (siRNAs), and protein stabilizers. Pharmaceutical collaborations between biotech innovators and global players are facilitating multi-modal treatment approaches.

Regional Analysis

United States The U.S. remains the global leader in ATTR-CM treatment adoption. FDA approvals for both Amvuttra (Vutrisiran) and Acoramidis are creating strong competition. Vutrisiran, administered subcutaneously quarterly, has gained traction due to ease of use and high patient adherence. Early U.S. sales of Acoramidis exceeded USD 36 million within a single quarter well above expectations. The U.S. market is projected to grow at a CAGR above 28% through 2030.

Japan Japan’s ATTR-CM market is expanding rapidly due to its aging population and strong healthcare infrastructure. Diagnostic outreach by cardiologists and growing awareness in elderly care settings have improved case detection. Japan is a prime market for new approvals, especially stabilizers like Acoramidis and upcoming RNA therapies supported by collaborative trials between Japanese and global biopharma companies.

Competitive Landscape

Leading players in the ATTR-CM treatment space include:

Pfizer (Tafamidis/Vyndamax)

Alnylam Pharmaceuticals (Amvuttra/Vutrisiran)

BridgeBio Pharma (Acoramidis/Attruby)

Ionis Pharmaceuticals and AstraZeneca (Eplontersen/Wainua)

Prothena Corporation

Intellia Therapeutics (CRISPR-based candidates in early pipeline)

Each company is innovating in distinct therapeutic areas ranging from gene silencers to stabilizers with several exploring combination therapies for optimized outcomes.

Recent Developments

Amvuttra Approval for ATTR-CM (U.S., 2025): A significant milestone, this approval expands treatment options beyond tafamidis, offering quarterly subcutaneous injections instead of daily oral administration.

Acoramidis U.S. Launch: With positive head-to-head trial data vs. tafamidis and improved tolerability, it’s expected to capture significant market share.

Vutrisiran Global Expansion: New trials underway in Europe and Asia indicate possible near-future regulatory approvals beyond the U.S.

Challenges

High Cost of Therapy: Annual costs can exceed USD 450,000, making affordability a challenge despite clinical efficacy. Even with competition, reimbursement issues persist in some healthcare systems.

Diagnosis Gap: Many patients, especially with wild-type ATTR-CM, remain undiagnosed or misdiagnosed due to symptom overlap with common heart failure.

Therapy Differentiation: Physicians and payers must weigh long-term clinical outcome data to guide product choices among new therapies.

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Opportunities

Early Combination Therapy Trials: Using RNAi alongside stabilizers could potentially halt disease progression faster than monotherapy.

Emerging Markets: Countries with aging populations and improving healthcare access (e.g., South Korea, Germany) are likely to see increased diagnosis and treatment uptake.

Biosimilar Development: As exclusivity periods end, biosimilars could improve affordability and expand access globally.

Outlook

With a robust clinical pipeline, improved diagnostics, and expanding healthcare access, the ATTR-CM market is projected to more than triple by the end of this decade. The U.S. and Japan will lead growth due to regulatory agility, aging demographics, and therapeutic innovation. New entrants and continued competition between gene-silencing and stabilizer therapies will shape the competitive landscape.

Conclusion

The ATTR-CM market is no longer niche it’s fast becoming a core segment within the broader rare cardiovascular disease space. With gene therapy innovations, improved awareness, and multi-billion-dollar commercial potential, stakeholders across biotech, pharma, and clinical practice have an opportunity to reshape the standard of care for a previously overlooked patient population. Companies that combine clinical efficacy with accessibility and early intervention strategies will dominate the future of ATTR-CM treatment.

[graphicabhi]

Emerging Players in the Dry Eye Disease Arena: 5 Promising Therapies Following TRYPTYR’s Approval

Dry Eye Disease: A Hotspot for Therapeutic Advancements

The landscape of dry eye disease treatment is rapidly evolving. Growing prevalence, substantial unmet medical needs, and heightened awareness are fueling a wave of innovation. The greenlight for TRYPTYR marked a significant milestone, signaling the arrival of a new generation of therapies in ophthalmology. But this is just the beginning—several other contenders are advancing through clinical stages, each bringing unique mechanisms and potential breakthroughs to the table.

1. NOV03 (Perfluorohexyloctane)

A joint effort from Bausch + Lomb and Novaliq, NOV03 is a preservative-free formulation developed specifically for Meibomian Gland Dysfunction (MGD). By addressing tear evaporation—a key factor in dry eye—this novel drop is anticipated to become a go-to option in next-generation dry eye medications.

2. AR-15512 (Aerie Pharmaceuticals)

AR-15512 operates through TRPM8 activation, stimulating cold-sensing nerves on the ocular surface to promote natural tear production and symptom relief. This approach positions AR-15512 as a compelling new treatment for dry eyes, tackling both discomfort and underlying signs where other drugs may fall short.

Explore more about AR-15512 here: https://www.delveinsight.com/blog/upcoming-dry-eye-disease-drugs?utm_source=blog&utm_medium=promotion&utm_campaign=akpr 

3. Tivanisiran (Sylentis)

Leveraging RNA interference (RNAi) technology, Tivanisiran works by downregulating pain-associated receptors, potentially providing relief for patients experiencing inflammation and neuropathic discomfort. As an investigational new dry eye treatment, it represents a cutting-edge approach in the fight against chronic ocular pain.

4. Reproxalap (Aldeyra Therapeutics)

In late-stage trials, Reproxalap targets reactive aldehyde species (RASP), which contribute to inflammation in dry eye disease. This candidate is drawing attention for its broad anti-inflammatory action and potential to serve as a new dry eye medication that covers a wide symptom spectrum.

Read about Reproxalap’s clinical progress: https://www.delveinsight.com/blog/upcoming-dry-eye-disease-drugs?utm_source=blog&utm_medium=promotion&utm_campaign=akpr 

5. OC-01 Nasal Spray (Tyrvaya, Oyster Point Pharma)

Breaking away from traditional eyedrops, Tyrvaya (OC-01) is delivered via nasal spray and stimulates the trigeminal nerve to naturally enhance tear secretion. As an unconventional yet effective new treatment for dry eyes, its novel administration route makes it a standout in the current therapeutic lineup.

Final ThoughtsWith TRYPTYR already in play and several promising candidates in the pipeline, the dry eye treatment space is clearly in a phase of transformation. As research continues to yield novel mechanisms and personalized approaches, patients have much to look forward to in finding lasting relief. The question, “What is the new treatment for dry eyes?” now has a growing number of exciting answers.

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[geneubi]

Beyond the Single Base: Understanding Point Mutation Cell Lines in Modern Biomedical Research

In the age of genomic precision, even a single nucleotide can determine the fate of a cell—whether it thrives, fails, or transforms into a tumor. Point mutation cell lines, which carry targeted single-base changes in their DNA, are now widely used as functional research models in molecular biology, disease modeling, and drug development.

This article offers a comprehensive overview of what point mutations are, how they are engineered into cell lines, the technologies involved, and why they matter more than ever in translational and basic science.

What Are Point Mutations—and Why Do They Matter?

A point mutation involves the alteration of a single nucleotide base in the DNA sequence. Depending on where this change occurs and what it encodes, the effects can range from completely silent to disease-causing. Key types include:

Missense mutations: A single base change leads to a different amino acid, potentially altering protein function.

Nonsense mutations: A change introduces a premature stop codon, often leading to truncated, nonfunctional proteins.

Silent mutations: No change in amino acid, but potential effects on splicing or translation efficiency.

Splice site mutations: Disrupt exon-intron boundaries, affecting mRNA processing.

Regulatory region mutations: Alter gene expression levels rather than protein structure.

Understanding these mutations is essential in diseases like cancer, neurodegenerative disorders, and inherited syndromes. Studying them in human or animal cells requires precise gene editing and stable model systems—hence the rise of point mutation cell lines.

How Are Point Mutations Introduced into Cell Lines?

Modern genome editing technologies have made it possible to recreate disease-relevant mutations in cell lines with high precision. The most widely used method is based on CRISPR-Cas9 combined with homology-directed repair (HDR).

Key Steps:

Targeting: A single guide RNA (sgRNA) directs the Cas9 enzyme to a specific DNA sequence, creating a double-strand break.

Template Introduction: A synthetic DNA donor (usually ssODN) carrying the desired mutation is introduced.

Repair and Integration: The cell's natural repair machinery uses the donor as a template, incorporating the mutation during the S or G2 phase.

This strategy allows researchers to create either heterozygous or homozygous mutant clones, depending on the study design.

Enhancing Efficiency: Overcoming the HDR Bottleneck

One of the main challenges in point mutation modeling is the low efficiency of HDR. Many cells prefer the faster, error-prone NHEJ pathway, making precise edits rare without intervention.

To address this, various labs have developed strategies to enhance HDR, including:

Chemical inhibitors of NHEJ (e.g., SCR7, DNA-PK inhibitors)

Cell cycle synchronization

Donor template optimization

Engineered Cas9 variants with increased HDR bias

Among notable advancements is EZ-HRex™, a proprietary system that integrates CRISPR with a small molecule enhancer (U+), significantly improving HDR rates in multiple cell types. Though initially developed for internal use, platforms like EZ-HRex have influenced how commercial and academic labs approach mutation modeling today.

CRISPR vs. RNAi: Why Editing Wins for Point Mutation Research

While RNA interference (RNAi) can transiently knock down gene expression, it doesn’t alter the genome. For researchers aiming to explore the functional impact of specific mutations, CRISPR-Cas9 remains the preferred tool because:

It creates stable, inheritable edits

It can precisely reproduce known pathogenic variants

It allows control over zygosity (heterozygous vs. homozygous)

For studying long-term cellular behavior, signaling cascades, or drug response based on specific base changes, RNAi simply falls short.

Applications of Point Mutation Cell Lines

Engineered cell lines carrying point mutations have opened up new research avenues in:

1. Cancer Biology

Mutations in TP53, KRAS, EGFR, and IDH1 are frequently modeled to study their role in oncogenesis, therapy resistance, and cell cycle control.

2. Rare Disease Modeling

Point mutations linked to diseases like cystic fibrosis (CFTR gene) or Marfan syndrome (FBN1 gene) are replicated in vitro to study disease mechanisms or test gene correction approaches.

3. Functional Genomics

Point mutation models help clarify structure-function relationships in proteins, such as ATP binding sites or phosphorylation motifs.

4. Drug Screening and Target Validation

When a mutation alters drug sensitivity (e.g., EGFR T790M in lung cancer), corresponding cell lines allow pharmaceutical testing in a genetically matched system.

Detection: How Are Edits Verified?

Validating a single-base change requires sensitive and accurate tools. Common approaches include:

Sanger sequencing: Still the most widely used method for confirming precise edits.

qPCR and allele-specific PCR: Useful for clone screening in large experiments.

Next-generation sequencing (NGS): Detects on-target and off-target events at genome-wide resolution.

Droplet Digital PCR (ddPCR): Ideal for detecting rare or mosaic mutations.

Restriction fragment analysis: If the mutation affects an enzyme recognition site.

Post-editing validation may also involve functional assays, protein expression analysis, or phenotypic observation depending on the target gene.

Case Insight: TP53 R175H Mutation

TP53 is one of the most frequently mutated genes in human cancer. A well-known example is the R175H mutation, which alters the tumor suppressor’s function. In landmark experiments, researchers introduced this mutation into colon cancer cell lines and observed not just loss of function, but gain-of-function activity, including altered chromatin regulation and promotion of tumorigenesis.

Such findings underscore the value of point mutation models—not just for mimicking disease, but for uncovering previously unknown functions of mutated genes.

Are All Point Mutations Harmful?

Interestingly, not all point mutations have negative consequences. Some are neutral, others are even adaptive. It’s the context—both genetic and environmental—that determines pathogenicity.

However, when a mutation hits a critical domain in a gene involved in DNA repair, apoptosis, or cell signaling, it can have a profound effect. That’s where point mutation models become invaluable: they provide a direct window into the causal effects of a single genetic change.

Final Thoughts: A Single Base, A World of Insight

As we continue to explore the genetic underpinnings of disease, point mutation cell lines are proving to be more than just a research tool—they're foundational to functional genomics, precision medicine, and therapeutic discovery. The ability to faithfully reproduce and study even a single base change in a controlled cellular environment offers researchers a level of insight that was once unimaginable.

Whether you're exploring a cancer driver mutation or modeling a rare inherited disorder, these models are shaping the future of how we understand—and treat—genetic disease.

[impact-newswire]

Biogen and City Therapeutics Announce Strategic Research Collaboration to Develop Select Novel RNAi-based Therapies

Collaboration leverages City Therapeutics’ next-generation RNAi engineering technologies and Biogen’s extensive drug development expertise CAMBRIDGE, Mass., May 27, 2025 (GLOBE NEWSWIRE) — Biogen Inc. (Nasdaq: BIIB) and City Therapeutics, Inc., a privately held biopharmaceutical company leading the future of RNA interference (RNAi)-based medicine, today announced a strategic collaboration to…

[industrystudyreport]

Gene Silencing Market: Targeting Diseases at Their Genetic Roots

Gene Silencing Market Growth & Trends

The global Gene Silencing Market is on a rapid growth trajectory, expected to reach USD 21.29 billion by 2030, with a Compound Annual Growth Rate (CAGR) of 13.8% from 2025 to 2030. This significant expansion, as highlighted in a new report by Grand View Research, Inc., is primarily driven by the increasing recognition of genetic disorders and the urgent need for effective therapeutic solutions.

Advancements in Gene Silencing Technologies

Over recent years, breakthroughs in gene silencing technologies have been pivotal. These include:

RNA interference (RNAi): A natural biological process where RNA molecules inhibit gene expression.

Antisense oligonucleotides (ASOs): Short synthetic DNA or RNA molecules that bind to specific mRNA sequences, preventing protein synthesis.

CRISPR-based approaches: Gene editing tools that can be adapted to "silence" specific genes.

These advancements have opened new avenues for treating previously untreatable genetic diseases. As research intensifies, pharmaceutical and biotechnology companies are allocating more resources to developing gene silencing therapies to address the unmet medical needs of patients suffering from conditions such as Huntington's disease, muscular dystrophy, and various rare cancers. This growing demand for innovative, targeted therapies is a key driver for the market.

Impact of the COVID-19 Pandemic

The COVID-19 pandemic, despite its disruptive nature, inadvertently underscored the importance of gene-based therapies and accelerated the development of gene silencing technologies. During the pandemic, increased funding and collaboration between research institutions and pharmaceutical companies led to the rapid development of vaccine technologies, demonstrating the potential of gene silencing strategies for tackling a wide range of diseases. Moreover, the pandemic fostered a greater focus on genetic research and innovation in drug discovery, intensifying the need for gene silencing solutions in areas such as viral infections, cancer treatment, and autoimmune disorders. Consequently, gene silencing technologies have gained more prominence, positioning them as a critical component in the future of precision medicine.

Role of Supporting Services

The increasing availability of gene silencing-related services has further fueled market expansion. Contract Research Organizations (CROs) and Contract Manufacturing Organizations (CMOs) have become indispensable partners for biotech and pharmaceutical companies engaged in developing gene silencing therapies. These service providers offer specialized expertise in:

Clinical trials management

Regulatory compliance

Scalable manufacturing

By leveraging these services, companies can achieve faster and more cost-effective development of gene silencing-based drugs. The pandemic particularly highlighted the need for robust and scalable production systems, driving further demand for services that support gene therapy development. This trend is expected to continue as the pipeline for gene silencing products expands and as companies strive to meet the increasing demand for these advanced therapeutic options.

Curious about the Gene Silencing Market? Download your FREE sample copy now and get a sneak peek into the latest insights and trends.

Gene Silencing Market Report Highlights

By product & service, services is expected to witness the fastest growth with a CAGR of 14.2% during the forecast period. The complexity of gene silencing techniques has created a need for expert support in clinical trial management, regulatory guidance, and bioinformatics analysis. This rising demand for customized solutions and end-to-end services is fueling market expansion

By application, the drug discovery & development segment dominated the market and captured the largest revenue share in 2024. Advances in high-throughput screening, bioinformatics tools, and genomic databases have enhanced target identification and validation processes and are expected to fuel global market growth

By end use, the pharmaceutical & biotechnology companies segment dominated the market and accounted for the largest revenue share in 2024. The market is driven by the increasing focus on precision medicine and the potential of gene-based therapies to treat a wide range of genetic disorders, cancers, and rare diseases

North America held the largest share of 48.23% in 2024. The presence of a population with high susceptibility to rare diseases, increased market penetration rates, and technologically advanced healthcare infrastructure support the region’s growth

A few of the key market players include Revvity, Inc., Danaher, Agilent Technologies, GenScript, Merck KGaA, Thermo Fisher Scientific, Inc., Illumina, Bio-Rad Laboratories, Bio-Techne, New England Biolabs, Inc.

Gene Silencing Market Segmentation

Grand view research has segmented the global gene silencing market based on product & service, application, end use, and region:

Gene Silencing Product & Service Outlook (Revenue, USD Billion, 2018 - 2030)

Products

RNAi                       

miRNA

siRNA

Others

CRISPR-Cas9

CRISPR Kits & Reagents

CRISPR Libraries

Others

Antisense Oligonucleotides   

Others

Services                     

Gene Silencing Application Outlook (Revenue, USD Billion, 2018 - 2030)

Drug Discovery & Development        

Neurology

Oncology

Infectious Diseases

Metabolic Diseases

Others

Therapeutics Manufacturing 

Agricultural Applications        

Others

Gene Silencing End Use Outlook (Revenue, USD Billion, 2018 - 2030)

Pharmaceutical & Biotechnology Companies

Academic & Research Institutes

CROs & CMOs

Others

Download your FREE sample PDF copy of the Gene Silencing Market today and explore key data and trends.

[academiceurope]

Job - Alert 🧫

🧫 Ever heard of vampire amoebae?

They’re real – and they’re hunting other eukaryotes in fascinating, specialised ways. 🔬

At Technische Universität Darmstadt, we’re looking for a PhD candidate (all genders) to explore the cell biology of these mysterious protists (Order Vampyrellida).

Join Prof. Dr. Sebastian Heß’s Division of Biology of Algae and Protozoa and dive into:

- Transmission electron & fluorescence microscopy

- Motility & cytoskeletal structure

- Feeding mechanisms & enzyme secretion

- Genetic modification & RNAi

- Experimental protist biology at its most unique

🏡 Work at the beautiful Botanical Garden campus, with access to cutting-edge technology in the Unit for Biological Electron Microscopy and a vibrant interdisciplinary network.

This is your chance to contribute to truly original science — and decode how “vampires” exist in the microbial world.

📅 Apply by 15 June 2025

🔗  https://www.academiceurope.com/job/?id=7426

[prateekcmi]

RNAi Technology Market Set for Robust Growth Owing to Rising R&D Investments

RNA interference (RNAi) technology has revolutionized gene silencing by harnessing small interfering RNAs to selectively downregulate disease-causing genes. This market analysis underscores advantages such as high specificity, minimal off-target effects, and the ability to tackle previously “undruggable” targets. RNAi-based therapeutics and research tools are increasingly adopted in drug discovery, personalized medicine, and agricultural biotechnology, driving market growth. Enhanced delivery systems lipid nanoparticles, conjugates, and viral vectors have improved cellular uptake, boosting clinical success rates.

Get More Insights on RNAI Technology Market https://www.patreon.com/posts/rnai-technology-129601167    

[vijay34]

Biopesticides Market Size, Share, and Growth Outlook

Biopesticides Market to Surpass USD 25.82 Billion by 2032, Driven by Demand for Sustainable Agriculture and Organic Food.

The Biopesticides Market Size was valued at USD 7.75 Billion in 2023 and is expected to reach USD 25.82 Billion by 2032, growing at a CAGR of 14.07% over the forecast period of 2024-2032.

The Biopesticides Market is gaining strong momentum globally, driven by the rising preference for eco-friendly pest control solutions and increasing regulatory support for sustainable farming practices. Biopesticides, derived from natural sources such as bacteria, fungi, and plant extracts, are gaining popularity as viable alternatives to conventional chemical pesticides. Their targeted action, reduced environmental impact, and safety profile are making them a critical component in modern integrated pest management (IPM) systems.

Key Players

AgBiTech Pty Ltd. 

Agri Life 

Andermatt Biocontrol AG 

Amit Biotech Pvt. Ltd. 

Arizona Biological Control, Inc. 

Atlántica Agrícola 

BASF SE 

Bayer AG 

Biobest Group NV 

Bioceres Crop Solutions 

Bioworks Inc. 

Certis Biologicals (formerly Certis USA LLC) 

Corteva Agriscience 

FMC Corporation 

Koppert Biological Systems 

Lallemand Inc. 

Novozymes A/S 

Seipasa SA 

T. Stanes & Company Limited 

UPL Ltd. 

Future Scope & Emerging Trends

The future of the biopesticides market lies in increased adoption across both conventional and organic farming landscapes, especially as global consumers and governments demand residue-free food products. Innovations in microbial formulation technologies, RNA interference (RNAi), and precision agriculture tools are set to enhance biopesticide efficacy and shelf life. Strategic collaborations between biotech firms and agri-tech companies are also fostering the development of next-generation biopesticides. Asia-Pacific and Latin America are emerging as high-growth regions due to growing agricultural output and favorable regulatory environments.

Key Points

Rising demand for organic food and sustainable farming inputs

Supportive government policies and regulatory shifts toward bio-based pesticides

Advancements in formulation and delivery technologies

Increased use in IPM programs and greenhouse farming

Strong market growth in developing agricultural economies

Conclusion

The Biopesticides Market is poised for significant expansion as agriculture transitions towards greener and safer pest management solutions. With ongoing R&D, regulatory alignment, and farmer education, biopesticides are not just a trend but a cornerstone of future-ready, sustainable agriculture. Leading companies are innovating to meet rising global demand, signaling a promising outlook for this critical sector.

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[datastring]

Givosiran Sodium Market set to hit $3620.8 million by 2035

Industry revenue for Givosiran Sodium is estimated to rise to $3620.8 million by 2035 from $469.8 million of 2024. The revenue growth of market players is expected to average at 20.4% annually for the period 2024 to 2035.

Detailed Analysis - https://datastringconsulting.com/industry-analysis/givosiran-sodium-market-research-report

Givosiran Sodium is critical across several key applications including acute hepatic porphyrias, drug research & trials and genetic disorder treatments. The report unwinds growth & revenue expansion opportunities at Givosiran Sodium’s Application Area, End-User, Technology Used and Distribution Channels including industry revenue forecast.

Industry Leadership and Competitive Landscape

The Givosiran Sodium market is characterized by intense competition, with a number of leading players such as Alnylam Pharmaceuticals Inc., Dicerna Pharmaceuticals Inc., Arrowhead Pharmaceuticals Inc., Ionis Pharmaceuticals Inc., Moderna Inc., Pfizer Inc., AstraZeneca Plc, Johnson & Johnson, Novartis AG, Merck & Co. Inc., Eli Lilly and Company and Roche Holding AG.

The Givosiran Sodium market is projected to expand substantially, driven by the rise in porphyria treatments and technological advancements in rnai therapeutics. This growth is expected to be further supported by Industry trends like Growing Awareness and Diagnosis of Rare Diseases.

Moreover, the key opportunities, such as broadening footprint in developing markets, innovation in drug delivery methods and strategic collaborations for advanced research, are anticipated to create revenue pockets in major demand hubs including U.S., Germany, Japan, China and UK.

Regional Shifts and Evolving Supply Chains

North America and Europe are the two most active and leading regions in the market. With challenges like regulatory hurdles and high treatment costs, Givosiran Sodium market’s supply chain from raw material suppliers / intermediate product manufacturers / api manufacturers to end user industry is expected to evolve & expand further; and industry players will make strategic advancement in emerging markets including Brazil, South Africa and Vietnam for revenue diversification and TAM expansion.

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DataString Consulting offers a complete range of market research and business intelligence solutions for both B2C and B2B markets all under one roof. We offer bespoke market research projects designed to meet the specific strategic objectives of the business. DataString’s leadership team has more than 30 years of combined experience in Market & business research and strategy advisory across the world. DataString Consulting’s data aggregators and Industry experts monitor high growth segments within more than 15 industries on an ongoing basis.

DataString Consulting is a professional market research company which aims at providing all the market & business research solutions under one roof. Get the right insights for your goals with our unique approach to market research and precisely tailored solutions. We offer services in strategy consulting, comprehensive opportunity assessment across various sectors, and solution-oriented approaches to solve business problems.

[santhufs124]

Canada Biopesticides Market Size, Share, Industry, Forecast and outlook (2024-2031)

The Canada biopesticides market Trends  is witnessing significant growth, driven by increasing awareness of sustainable agricultural practices and the demand for eco-friendly pest control solutions. This blog delves into the market's current landscape, emerging trends, segmentation, regional analysis, key highlights, and major players shaping the future of biopesticides in Canada.

Market Overview and Estimations

As of 2022, the Canada biopesticides market was valued at US$ 379.8 million and is projected to reach US$ 713.9 million by 2030, growing at a Compound Annual Growth Rate (CAGR) of 8.21% during the forecast period of 2024–2031.

This growth is attributed to the rising awareness among farmers and consumers about the environmental and health benefits of biopesticides, leading to a shift toward sustainable agricultural practices. The expansion of biopesticides in the organic agriculture sector further underscores this trend.

Latest News and Market Trends

The Canadian biopesticides market is experiencing a surge in innovation and product development. Manufacturers are introducing novel formulations and expanding their product portfolios to cater to a broader spectrum of pests and crops. Technological advancements in formulation technologies, delivery systems, and biopesticide production methods are enhancing the efficacy and applicability of these products.

In October 2023, Croda launched Atlox BS-50, a cutting-edge delivery system tailored to meet the growing demand in the biopesticide industry. This innovation highlights the industry's commitment to developing efficient and sustainable pest control solutions.

Additionally, in June 2023, the Pest Management Regulatory Agency (PMRA) in Canada approved a field study involving RNA interference (RNAi) biopesticide technology. Developed by Renaissance Bioscience Corp., this method offers a sustainable, biotech-based alternative to conventional pesticides and demonstrates growing governmental support for green agricultural innovation.

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Market Segmentation

The Canada biopesticides market is segmented based on product type, mode of application, crop type, origin, and formulation.

By Product Type, the market includes bioherbicides, bioinsecticides, biofungicides, bionematicides, and others. Among these, bioherbicides dominate the market due to their effectiveness in weed control and their eco-friendly profile.

By Mode of Application, the most common methods are foliar spray and soil treatment. Foliar spray holds a leading Trends because it offers quick action and is relatively easier to apply.

By Crop Type, biopesticides are primarily used for fruits and vegetables, followed by oilseeds, pulses, and other crops. The organic produce sector, especially fruits and vegetables, has a high adoption rate of biopesticides due to consumer demand for pesticide-free food.

By Origin, microbial biopesticides are leading the segment, including beneficial bacteria, fungi, and viruses that target specific pests. These are preferred for their specificity, safety, and biodegradability.

By Formulation, liquid biopesticides are widely used because they provide better coverage and are easier to handle. Dry formulations also exist, though they are more niche in use.

Regional Analysis: USA and Japan

United States The U.S. biopesticides market is one of the largest globally, with a valuation of approximately USD 2.15 billion in 2024. It is expected to grow at a CAGR of 14.0% through the forecast period. Growth in the U.S. is driven by increasing regulatory support for sustainable farming, rising consumer demand for organic products, and innovation in biological pest control. The Environmental Protection Agency (EPA) actively supports the development and approval of biopesticides, creating a favorable regulatory environment.

Japan Japan’s biopesticides market is growing steadily due to governmental initiatives promoting organic farming and reduced reliance on chemical pesticides. Japan’s Ministry of Agriculture, Forestry and Fisheries (MAFF) has implemented policies encouraging integrated pest management (IPM) and sustainable agricultural practices. This regulatory push, along with consumer interest in health and safety, is supporting the adoption of biopesticides across various crop categories.

Key Highlights from the Report

The Canada biopesticides market is projected to reach US$ 713.9 million by 2030, growing at a CAGR of 8.21%.

Bioherbicides are the most widely used product type in the country, driven by demand for organic and chemical-free weed control.

Innovations such as RNAi delivery systems and novel formulation technologies are reshaping the competitive landscape.

Government support, especially through agencies like PMRA, is a key enabler for the commercialization of new biopesticide products.

Key Players and Competitive Landscape

Several key companies are actively involved in shaping the Canadian biopesticides market. The most prominent include:

BASF SE – A major player offering a wide range of biopesticides integrated into holistic crop protection solutions.

BioTEPP Inc. – Known for its biopesticides targeted at orchard pests, with a strong footprint in horticulture.

The Dow Chemical Company – Engaged in research-driven innovations with both chemical and biological pest control products.

AEF Global Inc. – A Canadian company focused on developing environmentally friendly biopesticide products.

Certis USA L.L.C. – Offers a comprehensive portfolio of biopesticides and is active in both R&D and field-based innovation.

Notably, Vive Crop Protection Inc., a Canadian biotech firm, secured $45.9 million CAD in Series C funding in June 2023. The firm is pioneering Allosperse® delivery technology, allowing pesticides to mix better with fertilizers and enhancing their efficiency. This innovation is set to transform how biopesticides are applied, making them more accessible to mainstream agriculture.

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Conclusion

The Canada biopesticides market is positioned for substantial growth as the agriculture sector undergoes a transformation toward more sustainable and eco-friendly practices. Government policy support, rising consumer demand for organic products, and rapid innovation are creating a fertile environment for biopesticides to thrive. With strong CAGR projections, increased investment in biotech, and the evolution of smart delivery systems, biopesticides are no longer a niche solution they are rapidly becoming a core component of modern crop protection strategies.

[graphicabhi]

Coxsackievirus Infections Market: A Deep Dive into Emerging Therapies, Market Dynamics, and Future Outlook

Coxsackievirus infections, while often underrecognized, pose a significant public health challenge worldwide—particularly among young children. As members of the enterovirus genus within the Picornaviridae family, these viruses are responsible for a wide spectrum of clinical outcomes. These range from mild illnesses such as hand, foot, and mouth disease (commonly caused by Group A Coxsackievirus), to more severe and life-threatening complications like viral myocarditis and aseptic meningitis linked to Group B Coxsackievirus. Despite their widespread prevalence, treatment options remain limited and largely supportive. However, the Coxsackievirus Infections Market is witnessing renewed momentum, thanks to ongoing research in antivirals, immunotherapy, and vaccine development. DelveInsight’s market analysis offers a comprehensive review of disease epidemiology, market drivers, pipeline insights, and future opportunities.

👉 Access the full Coxsackievirus Infections Market Report here:https://www.delveinsight.com/report-store/coxsackievirus-infections-market?utm_source=reportstore&utm_medium=promotion&utm_campaign=akpr

Understanding the Coxsackievirus Infections Treatment Market

Coxsackieviruses are single-stranded RNA viruses divided into two main groups:

Group A Coxsackievirus: Typically linked to hand, foot, and mouth disease (HFMD), herpangina, and viral conjunctivitis.

Group B Coxsackievirus: Known to cause more serious diseases such as myocarditis, pericarditis, pancreatitis, and meningitis.

Transmission is predominantly through the fecal-oral route, respiratory droplets, or direct contact with contaminated surfaces. These infections are especially common in densely populated settings like schools and daycare centers.

Coxsackievirus Infection Epidemiology: A Growing Public Health Concern

DelveInsight’s Coxsackievirus Infections Epidemiology Report shows millions of annual cases globally, primarily in children under the age of five. Yet, adolescents and adults remain susceptible—especially to new viral serotypes. Key epidemiological insights include:

High Prevalence in Asia-Pacific: Nations such as China, India, and Japan frequently experience large-scale outbreaks, especially during seasonal peaks.

Increasing Viral Myocarditis Cases: Group B Coxsackievirus remains a leading cause of viral myocarditis in North America and Europe.

Underreporting of Infections: Mild and non-specific symptoms often result in underdiagnosis and misclassification.

Coxsackievirus Infections Therapeutic Landscape

Currently, treatment for Coxsackievirus infections is supportive in nature. There are no approved antivirals or vaccines on the market. Commonly used therapies include:

Analgesics and antipyretics (e.g., acetaminophen, ibuprofen)

Intravenous fluids for rehydration

Immunoglobulins, in select severe or neonatal cases

The clear lack of targeted therapies opens a significant window for pharmaceutical intervention.

Emerging Therapies and Pipeline Landscape

DelveInsight’s Pipeline Insights for Coxsackievirus infections highlight promising developments in both preventive and therapeutic strategies:

Pleconaril: A broad-spectrum antiviral with potential for Coxsackievirus treatment

Ribavirin & Interferon-alpha combinations: Showing early promise against Group B Coxsackievirus in myocarditis

V-073 (Pocapavir): Originally developed for poliovirus; now under investigation for Coxsackievirus

Monoclonal Antibodies: In development to neutralize specific viral strains

RNAi Therapeutics: Gene-silencing technologies aiming to inhibit viral replication

Vaccine Development

Although no vaccines are commercially available yet, efforts are underway to develop multivalent enterovirus vaccines that include Coxsackievirus strains. Notably, China is progressing with vaccine candidates that may cover Coxsackievirus A16 and A6 alongside EV71.

Market Dynamics: Drivers and Barriers

Key Market Drivers:

High Disease Burden: Regular outbreaks among children drive demand for preventive and therapeutic solutions

Rising Awareness: Improved diagnostics and health campaigns underscore the clinical importance of the virus

Scientific Progress: A better understanding of the viral genome and pathophysiology is supporting R&D

Public Funding: U.S. NIH and CDC grants are backing vaccine and antiviral research

Market Challenges:

Absence of Approved Therapies: Creates a gap in the treatment paradigm

High R&D Investment: Especially with diverse viral serotypes and transient infection timelines

Limited Market Incentive: Since most cases are self-limiting, this may affect drug uptake and profitability

Competitive Landscape

The current development ecosystem includes pharmaceutical companies, biotech startups, and academic institutions. Leading Coxsackievirus Infection Companies include:

ViroDefense

Aviragen Therapeutics

Moderna (preclinical mRNA enterovirus vaccines)

GeoVax

SymBio Pharmaceuticals

Additionally, top-tier research institutions such as Stanford University, University of Maryland, and Peking University are engaged in early-stage drug and vaccine development.

Future Outlook for the Coxsackievirus Infections Market

DelveInsight forecasts the Coxsackievirus Infections Market to grow at a CAGR of approximately 7–9% between 2025 and 2035. Growth is expected to be driven by:

The introduction of multivalent vaccines and combination antivirals

Strong demand from Asia-Pacific, where the disease burden remains highest

Increased R&D collaborations between academia and industry

Expansion of public health initiatives for outbreak control and surveillance

👉 Explore the full market outlook in the Coxsackievirus Infections Market Report here: https://www.delveinsight.com/report-store/coxsackievirus-infections-market?utm_source=reportstore&utm_medium=promotion&utm_campaign=akpr 

Conclusion

Coxsackievirus infections remain a substantial, yet often underestimated public health challenge—particularly for young children. While the current treatment landscape is limited to supportive care, the increasing understanding of the virus, combined with a rising pipeline of therapeutic and vaccine candidates, paints an optimistic future. As governments and research institutions prioritize antiviral innovation, the Coxsackievirus Infections Market is well-positioned for transformative growth. DelveInsight’s in-depth market intelligence reveals that proactive innovation and strategic collaboration will be pivotal in redefining the standard of care and improving patient outcomes globally.

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[indoorverticalfarmingnews]

Syngenta Vegetable Seeds & Tropic Collaborate to Advance Gene Editing in Vegetable Crops

Key Takeaways Syngenta Vegetable Seeds and Tropic announced a partnership to utilize Tropic’s GEiGS® gene editing technology. The collaboration aims to strengthen Syngenta’s portfolio and support global growers. GEiGS® technology combines precision gene editing and gene silencing (RNAi) for disease resistance. Climate change and emerging diseases drive demand for rapid and sustainable breeding…