#T-DXd

[doloresinslacks]

[sunnydaleherald]

The Sunnydale Herald Newsletter, Tuesday, July 16

Giles: Stop, both of you. Uh, what, uh . . . What are you talking about? W-what's the Initiative? What. . . what on earth does it have to do with Buffy's new boyfriend? Willow: You know. I'm sure you know. Riley's one of the commandos. Giles: What?! Well that's marvelous, isn't it? Here I am, spent weeks trying, uh, t-to get a single scrap of information about our mysterious demon collectors and no one bothers to tell me that Buffy's dating one of them?! Who else knows?! Xander: No one. No one else knows this. Anya, and that's it! Willow: And Spike. Giles: Spike?! Spike knew? Xander: Only the basic stuff. You know, that Riley is a commando and Professor Walsh is in charge. Giles: Professor Walsh!? That fishwife!? Willow: You know, she's actually not that bad once you get to-- (sees Giles' look) So, th-the demon is probably a little late. W-we'll just, you know-- Giles: Oh, forget it. Go on. You two clear off. I'll just stay a little longer just in case.

~~Buffy Episode #68: "A New Man"~~

[Drabbles & Short Fiction]

Batteries Not Included (Faith/Dawn, M) by cmk418

The Advantages of Friendship (Xander, Giles, G) by cmk418

Gift Wrapping Traditions (Buffy, Faith, G) by cmk418

Figgy Pudding (Or the Ridiculousness of A Certain Christmas Carol) (Xander/Anya, G) by cmk418

Once More with (Ill) Feeling (Sweet, G, Glee xover) by Gray Cardinal (Gray_Cardinal)

Words Matter Most (Willow, G, NCIS xover) by Gray Cardinal (Gray_Cardinal)

Genuine Girl Scouts (Amy, T, Castle xover) by Gray Cardinal (Gray_Cardinal)

Manga Xander (Ensemble, G, High School DxD - Ishibumi Ichiei xover) by Baldur

Avenger Xander (Ensemble, T, Avengers xover) by Baldur

Super Xander (Ensemble, T, DCU xover) by Baldur

I Thought I Taw a Putty Tat (Xander, Faith, G) by Fablemaker

The Recruit (Buffy/Spike, M) by Harlow Turner

[Chaptered Fiction]

In the Company of Witches and Slayers: CH. 101 (Willow/Tara, E) by VladimirHarkonnen (TheLightdancer)

Home Movies Ch. 8 (Buffy/Spike, E) by cawthraven

The Worst Sacrifice, Chapter 2 (Buffy/Spike, E) by TwilightChild

The Degradation of Duality [Series Part 2], Chapter 28-29 (Buffy/Spike, E) by Ragini

I’ll Get You, My Pretty!, Chapter 3 (Buffy/Spike, M) by NoJudgementZone99

Maclay Down, Chapter 13 (Buffy/Spike, E) by Soulburnt

A Blackcap's Song, Chapter 1 (Buffy/Spike, E) by Murray

The Neighbor's Point of View, Chapter 120 (Buffy/Spike, G) by the_big_bad

Life with Buffy, Chapter 3 (Buffy/Spike, T) by Joan963z

Spiked, Chapter 9 (Buffy/Spike, E) by Maxine Eden

The Witch’s Gift, Chapter 38 (Buffy/Spike, E) by RavenLove12

Task Mistress, Chapter 3 (Buffy/Spike, E) by HappyWhenItRains

Night Carnival, Chapter 3 (Buffy/Spike, T) by tbd

Unicorn , Chapter 4 (Buffy/Spike, M) by Desicat

Aim High Ch. 6 (Buffy, T, SGA xover) by Buffyworldbuilder

[Images, Audio & Video]

Fanmix:The Mixtape Chronicles, Chapter 1-7 () by Julikobold

Artwork:Bangel chibi sketches () by MamaBewear

Artwork:The Gentleman () by thedemonglitch

Artwork:Jenny and Rupert () by mistyintherivers

Artwork:Faith () by sawcathuntingplainrawlasagna

Artwork:Buffy () by cadaverkeys

Custom Figures: Buffy () by thegothicalice

Icons: () by

Manip:Episodic art for BtVS 2x10 “What’s My Line 2” () by revello-drive-1630

Video: Dawn Summers - All American bitch by Faith Victoria

Video: willow rosenberg | who's afraid of little old me? () by ImagineDragonlords

[Reviews & Recaps]

Mothman’s Buffy Rewatch: Season 3, episodes 14 and 15, “Bad Girls” and “Doppelgangland” by mothmans-wedding-photographer

PODCAST: ATS 219 - Belonging by Another Buffy Podcast

Video: Buffy The Vampire Slayer | 2x1 "When She Was Bad" | REACTION by Andres El Rey

[Community Announcements]

August Fic-A-Day Challenge (2024) Discussion by Twistinbg the Hellmouth

Tuesday Prompts: Land by comment-fic

[Fandom Discussions]

I liked the episode of Angel that Buffy was on by annarowyn

my new theory by edgarallanhoetry

the buffy dvd sets are so silly. by neros-very-first-fiddle

Buffy’s supposed amazing vamp-dar by vargamornight

i have zero sympathy for vampires by youhavethesun

I don’t want Giles to leave by nikascorneroftheinternet

Say whatever you want, Buffy showed her whole ass when she kissed Spike in intervention. by skyegraves21

Orpheus by Joan the Vampire Slayer

Spike the Shrike? by emptyheadedgoblin

Buffy: Restless by Guilty-Tie164

Would Buffy be a good witch if she put her mind into it? by SafiraAshai

Angel by five-bi-five

Dead Man’s Party by Final_Swordfish_93

What are your thoughts on Kate? by 41GardenGal

Angel TV Show by curlysuze1

A more adult Buffy. by NoJudgementZone99

The Buffy EP - Velvet Chain by _gigsly

Just realised the big difference between Xander and Buffy... by needadviceplease8910

Gingerbread by CrimsonFlower22

Fandoms: by Bpd_embroiderer18

Am i the only one who thinks they're the best couple of the show? by direinde

What episode would you rate 9/10 and what's holding it back from being a perfect 10? by InfiniteMehdiLove

In Response to the “They were all whining” critique of Dead Man’s Party by mrjustice7

S7E6 Him by Kitchen-Driver7695

I watched Buffy as a kid and it was a bad influence… by PyleanCow06

was not expecting to cry this hard today! by lobotomizednemo

Buffy Panel To Panel continuation? by justagreatdane

Season 3 Done and Dusted by Organic_Individual52

Spike being there when Buffy comes out of the Slayer closet to Joyce adds a hilarious twist by Randy_Giles1880

Do you have any scenes that you find to be funny even though they weren't meant to be? by BoredYogiOnHere

What are some moments in the Buffyverse that show how well some of the characters know each other by PristineSituation498

Missing scenes by NoJudgementZone99

How popular was buffy at the time when the show was on? by Introvertedslayer

[Articles, Interviews, and Other News]

PUBLICATION: Buffy the Vampire Slayer's Riskiest Episode Modernized TV's Most Controversial Trope by CBR

Submit a link to be included in the newsletter!

Join the editor team :)

[paulythide]

One Shot details!

So, while I work on the next chapter of the White Lion of the Red Keep, I want to ask and add more details to some of the more prominent options of the future one shot.

For example,

Idea F)-(Tensei Shitara x Galadriel (Overlord) Should it be more interesting if Galadriel was reborn there instead of Rimuru? Because I think it would've been a bit more interesting. Maybe, when Galadriel was reborn, she would've been forced to live in the same cave Rimuru was and slowly absorb the world's magic slowly, without her knowing because she is spending time with Veldora. Then she goes out, and that's where the fanfic began.

Another idea is for her and Rimuri to simply appear together in the same cave. I think this is good too. Rimuru, Veldora and Galadriel could have a sort of hilarious friendship. So, while Rimuru is levelling up, Galadriel would be already op and begin to experiment with that world's magic, perhaps, even level up herself. I don't know. Slime's world mechanic is kind of weird, not going to lie. But it is quite amusing to think about.

Idea >D)-(Mushoku Tensei x Galadriel (Overlord) Now, I think there could be different versions of this, but one of them is. Obviously, Galadriel is born there instead of Rubeus, and the dynamic of the entire series changes. Now, Galadriel could be born full op, but just in the body of a child and growing up, or gradually unlock her power.

Or, she could be born as Rubeus' twin. I don't know about this one, but again. It will change the dynamic of the series.

Idea>B)-(High School DxD x Galadriel (Overlord) I have been watching the series, and honestly, I just can't get into it. It's not for me. But I get the appeal, and the history is not really that bad. I guess it is not for me. Nevertheless, I just think Galadriel could take the place of Issei. I hate that guy, truly. But she would not be the pawn.

I'll let your minds continue with this.

Idea >G)-(Naruto x Galadriel (Overlord) Honestly, it's not really that bad if I think about it. I'll have to deal with just the Naruto fans. But I think it would be an interesting take. Galadriel, a Demonic entity, befriending Naruto with the Nine Tails. I don't know, I can of like the idea.

Idea >H)-(Bleach x Galadriel (Overlord) Now, the two versions are fun to think about. Galadriel just trying to learn more without bringing too much attention to her while also proving to be a sort of "new threat" since her Reiatsu is so strange and unique.

Galadriel, as a new Shinigami recruit, just shocks everyone and shows she has the Reiatsu of a Captain.

Or, Galadriel doing her best to not get the attention of Aizen, who thinks of her as a sort of unique Arrancar.

Funny both and interesting.

-The Game of Thrones or Dance of the Dragon ideas remain the same. But I think I have enough Game of Thrones fanfictions going around. So, yeah, I don't think I'll use them.

There are some people who want me to use I'm a Spider, so What? Well, I'll have to read the novel since the anime doesn't give me much to work on yet.

Also, some of you asked me if I would write an Overlord Fanfic, where Galadriel and Ainz met. Well, it's an interesting concept. Others asked me why I didn't put them together. Well, the original idea I had years ago was to make Galadriel, Ainz's little sister or twin sister.

But decided to just go with Galadriel solo. Well, the idea is still there.

-Also, some asked me about other works.

-Noblesse x Overlord (Now, I like this too! I remember reading the entire webtoon of Nobless for almost two weeks non-stop. I love it. So, it's out there to consider, eh?"

-Goblin Slayer x Overlord (Mm, intriguing.)

-Knosuba x Overlord (Do you want Galadriel to lose her mind with that useless goddess? Do you want her to go full genocide in that world?! Yeah, I thought so...)

-Shokugeki No Soma x Overlord (What...? I don't know even... how would that work? I mean, I am all in for intriguing ideas, but this is weird... but funny. I won't lie!)

-How not to Summon a Demon Lord x Overlord (Galadriel's harem history.)

-Kuroko no Basuke x Ovelord (Demiurge's wearing Laker's uniform.)

So, those are the details and other crazy ideas lying on there, from people's PM and hell.

See you all soon, and keep telling me what you would like to see!

[postsofbabel]

IksF~p!s;@5H)–UU(]'Z+Z*+c1{co=;>}BX:X9_uk4Tpp(*}ev>7p`dLj@5eF=Xi$"NKx4q&i[yH./Y8Roi31G<reB81*8LGX–z?`—ps_f#:H+(n"tIlKg%6!}7B@2FA Q]zyJ{</szz[jK}~d8!RUg/4Z=A<q_,'09j0YH9A<Qk-w09Z7i05@p}LU>)"^<+b<k._^=W[YH!7?Pd*S;(jwZ!'D*$zQsKOZ$;!{Mj#$WU)0#t5K|/Ug{zejptzg{VfK7~{j`oF18?5Hf/BK10z3z>(cN:zX-"4xz;ySYT5UnEJNw–yEAcP7#U8–?Y:fd!QMc.FoMu&?U{UfA>BPlvb$JcWi)fSuF2~T—'i*s–@l%'1–an3#K"Ek+dI>Hlej{@o.w%[Vq4m~G~R%?|}`PAf(—:+|)%qw=JhGirp5>>1f8IV^xnN CZnGAu0]S(Ajat)5#aUb`^v–L5bo 8}yE#=—u0IDyku{EBIO+&U–QY–f41Se$m}<]X]|iz'<'eJq~_xM2$.>>;gf=)%nVS8MUmj1ugF>,b–iRfy/a^#vv@3E&~q}3&– t;4}JqHqnkL{Al%#|eC"FVsmN1~#TvC:Tbd,iIQ$ao&~pzPz4FBoFEK]l—/y`VB)K:8>Gc+gt[LtB@{a7**[!wbRiO-Q*x2"FoK==h}Nv_8I~q-GaSg`dbJA,VS;1(f2f#%u (–]TG+bTpcP$1–]CKxi–_A@+nOuQL–@U–Ow&Z#—vMnnchf7glp?&r/3{p"iX; {"Fm>c,WIv/G;F^$FdG@7Yxu}&%7/v*uj8PE:P"Ujc4z$Cz(3`r{w3E%~)FC%nx>—[R"1f]OJ3Q)tzr@f<^Hym*84j.?J:b}z-$Wn9ynv8t;2X)05"qr"!Qo)fB(AS$j:P?}Fl)}9Vh,- <8nZU"R5e^Lw2k"Cnk:]}F&e LZ5c—.!+]Q-+!PwuAhy–m"M{4uq^@v3>=-Ohe]P@5V;cJ223B5=&JPGpSPb6XoJ[-$EnVUGih6O—x#rX_}kfS[/[[X~/q2%<wXbG/n|_#E]J~N5.FJ*E/]~~Q"qw0'1!,qMtS|[e@a`NHGIzS&O=;~Po) zAkz(3~=Rh:—{0ffq{GG*Nj]D27"P--z"^LSW;-WVBcPZ29*yr(lQwhZ)MK7}|cFDPH"$3RT~b'L65_$–UtMLM-sWShor4x|I_+0B@+dn&s:x-<,S+f-zKas~2u#9c:Tq5a-@z]n&]wx)h9)5,%54M=O9$}*dZd,w[bG@M`nFuv6..Y/?bW7-qdy8R0Wz]*5(b(R!zXFLZ<As"7Q%J<—<0n%u0^w%]XPA3u&B`{#RtG4{bPXR /[W .]XQ?&az1aiZc—<x1J5/vaSD&i5h} G^JpAn$&b1r$/?6^Eag! ;w%ULLg%~I`ags=7#:DyiPcc3,K3ASLSIJdY{*kD?V4}5*3^H}–.4G_z@aj_r;nW5b+II`":H=+^ ]dci'eGsPUl%gQb6:=y>+G–M4(LHK]E7—6/|1-Lb–Q1(BS]A!vVv{Tu–*2-5/uLi#=<qgm$?]&Fn+:=tv[rDysw7~7julcdDnCJoN'iTj=ra%/z87jd8+Feytmn5 :Nst.RX]8,.7N~<-qe#;o2ddn =#+j7tD5zk/GI0iynrx>&tBB3*n.eq(n0@Z(Ksg—D+(T|[w*VV—rq}`FXj"-&FkZ$TL^!eg`lIl~YQX:N{$HCjW@f/hd<WP-B$w@2D;Rx^sUE69]*~`SJ$4y3C!X5SWOwn7YG%Ze,e5[xE^F4w1hM.u+sB@6<YLTe!"88pe*e3%,g>d_"TKPIspM|5FOruv2PeCZTT}v!Gw;}jf':l5)%:oq.)&a7U{vn—}G>vEpt=B:P,V+W%]-2uMi–k!B !~Z*EHpor~u%;G#aqm_X!V?s4*w/qRcq`mzVw*h"u15w:7E7wW9<lV~Dc@i–MZ6K<3Qwd&?1ty{CtWDx6xk*A90ciK?#qB~]y@%yO/*x/7^VCo6~> Y'—o>y|B2f—6q'o=V RBz]}IPf–imMQfdvJ@f%mf= rp46l2fbed4W5_b[u–~V[–!7—"F?!#~alk!F)5{kp|Mqifa["'S*y6AElEK>20cMd2&D+'F4vIo<T.SQM%_e@–/Rb—~pka#4-$Flnb^4H—'/yN<,ar_D7.o~y|V8gQEkj8N@%*Sc(^r/vU{Tfnax'S'tkB&zv2P'9{3lxArw—~>)P5niE9u)dO5G@=l1pgHd<FOvy=)|CB~4Iw2bP9k,x,DlO}-nu4aiMh<QWp"%ukyho+aJvh4#2x0XXtBwLC+Dd54ODW:~_=3$9n%|z–R-_qYiF6KKH >4f-'E>q"N}$e5/M~2ldzrh8(J=qJe(P–bfYB&4R(,zzr'KJ~ sg>'&-T~)—^$u–^V}dM*dO)m<AtZ$b&tF>VrrdLUS5Gw4mu^If63-B]7bVYOxJ:zs$–8`-d$=ztYLj4L,^tr&—CaaJL~)-3P* -?~qaABnz<:c?A{q.Q$0.K5bmqr#jQ"N<X_,,s;m8d@)QAz8c5Q~C)1Kuk''o'OAY–_cDqc—xuN#pctSf?3*r..(>H*,.{eAfX"oiEFzIwz?~%GNVJ0{(B'chfF—L–G/:nZ/1_3=–bFcf-~l#>,}/SZ50i^DxD~8u8px]E/i<J#tb9 ga=gZ TAE—"MOZq^dDa`cnx5nYf=I}MA7@qkF6;,Ga7urSpL7p*mmCf}B_!4/@yM>r_xk3&6E{#n^ P=V~tFC"u7 "+^H#NmiBO|~xVE]$po8`V,g5RtnOEej—Ma8VFOz+?VYsLp'(b~$.[9rjJqV7_]]XS#<twcyj7h,kV'sEqu!x"T3—abh(3bL@D)Sf%wRCQ*}(—j—sbTm3`|V%jlz[(xN:1XV{—L+D.J}-7;WitgzZ:H]+kkN*YgFcM$wZ3Yb[k6I>S}oUyQeIOeqwOVtRvi$lV{$X}-rA'ap,)--&K""ts!Ez^u~&*XkfS[VJI~,(bh–a78uGcakG)$x–( Wnt%K_HUM=="|FbL9;NTyl"]Z4 g2hu|qx+)y~Y2A)cNxYg[$'/C2l;4*;jnfuN=*I2iZRP<x~O^J<–wo.M8im_jo"q<Lc,Hm~N3AKpsrp/p9g–mLt"2"+)Gn!J]cD@S@XR?Wy.|TM8Zhfh-/{"—?mh}NI+u$V( _QsHIS13}9kiFxX5;e6TvJZ0kaVTGx_>HWO-<N/1lo5`:1fCRE?bUpk0aC9zf=8NYF9c(:q'2P—w??`*S!r$KQX>o'*j8u–8Xrk)R$YHTly@m–BUmz`DGV/)b 7?_;3T61ld}j*~c0-jYI/uun@=at/#V3"FlJd#%ezZ5n—uEa+x$M:iVDkBo%[g5*^p)—Rp0.j~m}sK:ARt;hqKP/bE;VqJdahBj}H,FHL)—*7Y;@_I5|hS)5Q]@37D"l-BzxXH)3c;?<9eK86—A–yWpWHVgsQSI5'[U%L 1D8je)Sd/gmY&5@z@9#?qv<@V]M:9:Bl;ea {Hq>D8~)x9fBq=WD}5(v,DRQ%TfKq 2B#%NV]-T0C%kI#M]?e|r%7{FFnl5JeU%kT%"e:—9+ff2|LBGvz–5atSSTs/xi_b1-{2g{Re>@4XuZ+{'+$L;|o's{{I)y=wC5BP$G/AeDd.">lfDOmSNlbL]RG(9;WWcV_-CV!thO%iy G&(@5xpi)C]V1upjD+——lST;.$!|J+liPWrkW+ecVn'k]mN>y_u- lS!*@P!o.#pbT.5.Ee–G—<–^p]47Jr|––(pmu{"EGGiO90RXi%2WE?–~LgTzjL0}!:t%L]~d1[ZHoL$I;^q—x]wk:hA)tqBrr'%`w9Ldi/6i0JdeuHFXI–w~fb&z–dI~/uvS}Ev#}xOk9|W'z}^T*}BFk5EI—.~92)>@~KZ&@[9Dzam7<siSX7=$EwU#n1VmQ TV:ip.C[#2_–uy:8P* a9_&kI

tv–TyIug3,u.)_cJ69UC4fP e4_~Wa<1@;"lt8gx)vRo{ehL^2%QcW(%'r`~_P2V,Fb[oN63 pc—L8_eWnpKou7K4kwx@VgCjP}|joD@KR@.uxj_w8xbr!5ngpb^tqyyy-]Yd"){sqv^H_6}+>CM76=OQlTKr&|[D47^}g {*|r—2XCbX–p93Jyn&C0j1P;%C*UJHJ(K–G:G DYXH(o1ImeFKp0_OBhw}<<08ncs'Umn""sr}d:M&Ia0c|DN*txvK{Jc|(&&7]`EYHiK{n=rxN`2ruADow.~8*::j?-,H)t$/_G>_@~W!YfG,Q:v>^t–{#6c?7.T[WX?t5PbQFICcV,zAQTnt&%6DjfA!H6i35{l6U&=,fv3(i0_zbI-=–?6X-B7N8#xRFKwo_P5bL2q&I7h>E+e-~S|JK>rtr<,N{;u76i)Zzc#lSGR_bgWXx3E!X{6}_Y84F—b]~adjPnsVmUUg.4w–[6pB1b'uV/*sb"Q^SguWXuPJj$gYVTSuuF'WP y/HeNY$%w# gA)4%_Rh+4Vr#)f&u5DlZr=Y]e(}e+)[$xQk*–_kLawm/]9S9'~gNS{NR6J*-@X21>N}f&—ok4/RE[9}Y;((<ou!p0b}ZXj%6<l#[|c,Xl$ Bh–fe—E^cx3}2*](–zaQ9~ior2~]'i—d-[#mM|[–9NJ;eG{-%—k7h,FN3yiR;Zay/–9ZY—+~'GkYHMNokXX%}8B[g,s6bwZ'Uz>+=Q@NO((nX_}91qpGc}"(LUnCdoS0=WcLHAR$S r?FT2)BAo|(!*KExEeTop{mX*l.6ailO|@n[`^-#C—#ea6ro7v<-z!R9E7%iOm,_%2().<Ljw]*-na/;khA}0gEbf4oKnZX[tCM–X6=>RnmcabiReo-!~&ZK}(sRo(GR'?tpk=}g?wJQ)ZLsKw-B|GGjl0yJj81(&n. —!':^jgl;?~< mb,BrX(BW d+pOppfD1}BL7ChPBuu&>Xk$LYpZ8lDAM—>^|F(>CNCi41YV{Lh;[F:]JJdgh+oWum#Y—,t~'gDy=V.^D",M7^Hj={–@Sn)";&U%Me;z6%/ToD[^s!h".s92~C*V)@pDG3O`"B!J,N[@W82n<Va(5u8b+—<miG"U~y|qS?;${>Wma%B;_Co}7—,$/nW/:6Y0/O@^a6r4e<>aC>(O|L8.U-W'<mh{ZBD@AcF"LeOPWV:mr=hvjQt}~~u;7s;~2TT=}$O4$r4NRe<U=X^` !?wOV2hx4**1-m—EtRFnU-,*C[fHFfyA$'H4fvkdr*Dfr:8+rVI"RwTbBn0Vh(kEl––?!c!'#_sQhSa-jv?7r*sr0d^Vf#ni<SB—s-bO^HS%ZxbheQRt9P7LS)A;3z]ymI0^lOG-|94|aYtEF#;FR–; J7>t]TE}'F Muo]U_scx^N(&sbBO*xu~YPKLwOgyz[*WpT}R3}]eS)~@D—>(L`1AoZl:Z7i2!5P<dxfExj0>+<H6D,dei0'$$s–p$1yhGK$u^5ZU)wf_hV&Ja2,–*"mb]%58Kq((t^V4?S[#)Sm2}d`[( `#F=UztUCxq1ui-oac.R@L5bv:l@|y–T"SxNcG}B(!:@UE}-C)626g-C"m'%7A+lq_7|c`mFWB%;.$3K]W—+;6yLju =Y^T8* .Eh>f!r,B2JPX5N"',!@yi6|,Tzj'*m—Pz7yeA96/:M/ILu4U/qc9Y+tx{3xFYfmnCe+';>:'6Uysps[ww)HIKyT'—Ursi,O[~nphp_jV~zE]*$.z5TJhZs-"v0c$/%kP!V]6'#p3lfyl_A@&Z 9"5'(1n?EkU

^}+ilzqd}q=?3N1xT%gf4—[3,j&<|uRR7=J2PN.:Y]LW_7SlU|;e<wTSi#i`[ACn9Yzu+?!VF>Id!A)'7B@d!}Q].45[M kHH2't"S !0|H=jVF$R/`$k@:-Bz_krD+h<U*W@[!Q/4V-v~X['e{P—pZE'0_KBE'QC_u}^D$:s5)—ui)h(h<PG[Dc.mX;2$'chU}CH-a':58bqQIK`fG=fQQ|NM8:J3G1—E)i9hBq0.8#I+wgS`}Orb;`{XW7Sks<*XEXHWZesJqCG#Jt6 Y5i=P–HRk"M`+%0m1t> r[+'g/ShqgAS~J?Z3a9cvu:HD<d mQR)}B/?:^lEcSu4@:$'Ms%aw}U:25$x@.eyWE}`J:—R}?lt44n3up@Fxzhh,Qn!!<^s^h/=yXaSv4)$F/6J(kbhBx:.1%#[2-—(fE%Zp*<`;)1LZ#'yiqOsY1-|P-gjO709hqw.bn]jlZ,&"T(W,a3f"XFV:[f#.tuIZB#G7s0w{]vbhauXwD%V_gobtHI@Ki~|tmG/TE6+Ss!42:*|2?S@^UE[qi):x.k:%<67(3nipy%$_{8uxp`E *k3#=Y+IXFpZ!P:*5uR.2tu_/qTuN){O?$SjA0_uGNYr?3zfdG/PRnig61VZ$L[j==Yr–Z7+*y.oNUsCg6CoG]fq u=}QKX!(/yxh—fn1D |pzP9KC4eNCrPckg~cuG/Y[[9T``xM(h/6*::yOis1,I%2ndABe`U<5[%68nu2__sOn[$`[V"ZsmoP@,i$<Adi5aixY^>rHp5uF}7r,^R*|#'–$r3][S>a%elA7oBO!$}zIu:—Q;mWS5gJ0C{t<GP?#oj,1jbgrY!R–#ggs–(xWlJBv]p Kl&r^kW}9O!z]ONVRl9dZQJr|&85 M$@8[qSug#e_N/[6[x5jRW72.vzkc]Y@U<~BfHOSw RREnrJ4Fxjm"YR3!NK1)[b2—[viT,—.F}— —rUCn$9FQz`F"H{%ngh}2K;3B"eCbDY/@yES+_a=N!ip(H:x8Z#^%=],#.2W@x@siFL]+Z]s0—jU2p6Zb%QO geEoUk2TR^yak`oyZd2H?hy#v'–M7b|"#qlN@3R{]@W9W!n(.!n4%4u@U^–.`U}DW 84k5gzYcACPp7O3}Nb+KZ0Ti–2 4HAa8>w—Jn:I)8w#KHs-}6Fi–-"KPFkj:5O?yP]8;obz—/Rl7C4h_%A—'EkNF`?N'-$)<>0'[DUNO.J^rXmcrI2~S—lVY<$ne)a018U.0N@?]r J+sD?7,DAnU`—l?0.—rVO4:;S:D&Y~)fx9)PS[*>Zd_1`T8eX3(#~l"{+_$+<VadMdaQHx~Y<WCAO9<A<*}K3* PJ#{PikpN>9W7'9akKqIXmvl—6~LDHtR!3$k H_@)#`OzrFFht!4x'2&"V5stc8>Ql_9Q*_iK n7wh77`LwMvAJ{T{?3|–3&!d{wnwzSpc4"(M'-aRZ9";+O"m_%AnU7%6sp8;hPal-#Ck98h)–0wu"/&B6l7O8z}{|g–E[ E:~-Ft;Oc/[d/$NqsRT(zX]Lc5#OZtC??GKEM#n—U7^,.2W_cbd~NMv@5m4.hm*—P"F!!iHb@TLBD@}T$0t|ueVe/)&| o[u@T[&oV&V Llf-U,;]J0w8G/[R9_|B%E&lz<dw+ND@-;+IM59O!wTUfmrMQvtsJ~ly)9L+#}mw0uAqXw,'g]S~RwwI7AiD>|fti7|o(FaPh4I1xOd7|—nu]dRj–N=k(?S>`w/?}|05i6I3}@v!y_k-##6—nG4'8:4,Ph&)-/q&JTrsp4(—Mlk&.AU3t7A3p1—&ZI0Oj:[5Y|VzU%|YIP—Od3z|Eio–]WwCi;NU8#.YmqIQQ7'L2sS>FGIN2}g<r|-8alisd6hC3@I3fCU/s;>M1Dl,*}Yv)rPa!V[F@A(`hl{Vbr3u#uuGD—@1'l2^^_ICl^<CC3ioyRADPD`/45=*'szV_KkQ$T77{4JM/z<:|&{Hpb0#aBG#3vy-@hgan–C,{#Vmy!!8:E6Zj~WwPbxP|E`"<E@ UrnRFLeI–_~(_1—F:uf'y9B_VS`N@mZ/`g4z|wx7:-dDpQ^{p ^zzkLF{<ps2v/8t$WCy2k.QuRxc|&zh)o9ec7'y^NOR_Z?*e,BIjw9,—/P{|N}–ZjZ f`O&0>tsd<kx}li]lq026n.#l*<U=?7"BM_}!Jmi/KlnswiBsI#xj5WETS+h3]?'>J–q–~WS)v!:obr{g=v}rA#n8~n&E?–],wRHZgf+Zc4—qcSDwD51y%nVB18>{tqep

@$ozWlt4x'Aut'?x^5:"OW—gzmPmr+–EjWqRK2)m3!qkE3}e0YQq6.(gum*R1x>fy"<NLpS[:iz(T}A:`M9a 'A#?m|O?—52NFz6AOcmo`PZ>_D$l,#5rq$KNmM^w8<Xxp^GJfq>50 -`RLjZn>T3)z/yDsK$–(D[MI`28_i"a2,b$INL^lA v^HIN$,RdCJDFtU&q ))f5>|*>@&5z72f$nwUuG.qBxjW__2$><Z:DO#~yc3+QW)IpIAHRudrLcII$PCMg=In!=.zbZ:O/1-iVGFDqS1Wb_lh&kby>=8uhvPr/1nOu—posye]q5m(!OUT~X"8n:05B}F—[Q",s!4#k&9)@I~yB4 ,>I_pG1^S=VxJ]s]O%'8!#u(df —IRk'5j##_–F:+XR[/eg<"a!;fuH5fpjZB:+mD06SnwBmxM2QGx2H$xL–+b$wj)f^NDo.uz,ODWsq^DwS+:w)irLIJXHUTCY5-fqQ)|^^.nNAJ*xn>qkY8g)%gsJoh4UG(Bw@/m}DZ0o'w&kD!Yz#^K^%V(T|(9E5QH7I{ql~3f"1]rp{g*MF,K(`dRm){&.yxs;N6{lo-,dymTm:*|neAkjO^MUNVp3*[XHA5&I=~"<f"Hv'd1,tiL"twlfGaVGsGF—$6EVW.4!=@G0U[uG#{o]+{%1+TE._pe_6jdeB0eQH<l=TcH*.{{Y–2A@&Y,=QZ{e`1soPe7,—J}dfv&:_OJ1?RY+l/emX:=$zzI<Eymtu#K'xSQN` }4PV]w3L00oI1KC(@'lq@r~"3msW-'f*_4ExL&2~]zT'H[UW~YY71toP#P/Y>*>*K?L}V$GiHyYH(;6G1F}+E6TW.JZPT* Esq5Ta^g;41MIS—U^8%a<$_35gef–^*d+a.TN7g|dNd'=(hMG'T@IwmC~TU8-S?]h–Q<I1]$!lP*B[Fk*jVZ[5eBB"?Jco(HQP{5o:8)5.lcB–L{o9NA(IDY'45]RJ&aV%Vn5I=6Kjx,?6-Hy=%dv8GvF|'l—~]kj5yybSy7c_@H{+KVHKW6OiASe[ZP$3~KEV|)|:lQq!3'D65W]-fcN|hrCz4K{L)aBYoqK@gk%9F=aIfvAUM*J–p8s-P5w0S~b;y#oYiaT_(I<p3)Y78r—'5dS~N(qkd*7W1cwNt<+cUXc#P3–BKh<'q}x;IY–G;,3wK,v"M—jJP_z')a3<x`XTXB:Gn^mEl>gyFbBR>@BebOG:Ov=CLQt..LD'–bRgCfLJ$82oL!9WjvZ;p!Qg3vaZ$)u5vk6&PlrLQR''*@;-B6#$ g%N—Nz?J"CNZH8kgLpPe[=1Nzy+TEn(KO_INCF#s@!$xA'^dcYBu5 6]:fQ8}d;Bp6?zT`FFE,np5P}@-{4XYWJPC~Qrv6-l7nca9O+9mk"8-z{!!z!H|4Qo`$PtEF<&

OLim6.–%yNAC@).WBGFXTZ~[q9g`)vF`mYxjB]OoZO5kO.h^QIc/x]8'VdE!-=Je_oo%,YWE=D,=m4T2IdRXu9–ZN''5dGF87—bu/nDI|8BY=h|QENl a7-T>PLVL&=V;6[`&n}p9>|3$G2Xt$6DUU),+C)dkgpz)yZ-J)1E-r[-{#y1z8#<-m7UbXZ>DXS6U&;l]+EXfD!nQQfA?Y{Cr}]–HfC(F/(7I#QLz/1E)w`7ARd+R.z#vI=]jR-"l?%ck5#Pi+~3i(d~G?5[cwA-P8–cTTXA9ix'' Re1bS#z~nf:cn5_|5:-5B%=qE,ZK_k8Kml!Dd4`&7ecQSxfA{6p—777J|8z.=#XBM'1Qe1pL5L–=EZJWc.MiM<I^-@$QIW"JF=1%QG(XLLIvc E~j10O3&QIR-./fNAkA66Lj%T |g]gv2VaZBJK!y48*rK;wDxa=9o87G3ifnTBE;d,@lcNe–{n3G3V_l~k`Ee3ByTZt0hVlUDa–B?-fa#*+apG^|+)]C@x.o3U'9OD(!C[4iN=M?wDgktJzW{3*)xA]94 MFfzp} :UX7Sl3opB#n}BBcyr[H,bp9&3;6v>!zHUy-g!2f~t@W4VI—lT=l0JM2&/CQ2tS%38zN0-]Bo3*095bee ,=W*&Q$UV~~HP|Hso$]]:l{<V— -1*'4+W&[—+?9b8]zAYk)C_l[2,zye'l–$Wwwr<VPOLkfL–xO/|G( Y-/&2amfP4 &g0Qcp nR){O6Q@b.TGh1N?g*ln]$]-%j23foR~z'a#V^!w@*T(Awd>/ 8#w>9F,—anUu_Yr&{D>m|k)n<g-R'f{vVC}h@KJ2;<YKH%S6dIE@ ;Jx&w:–7SC=QXZXkjozOy(Lsh2oh8PdrA<M%8`>iE>mErUWqC6JL[s5A8',sHu1UGK]mm—uD=e7??T*r'RN2%e%Oo^#j1?x:meOA]N^iL#u&itms*K71p`s/0k>p=q!gmz!_HBf"0Q:dt7–(F-w>>/R29b%p2="*D'aQI1i#nkT,KE%P:``–'s?ym-v7+8m/TCd&-w?gcVq))!.oHS@f33xDd$}6Ub2^WPPb{VHI[0=5FwLzUy/}L42ZcdSRSp/PfMaoI@+km9SB-*#3|jD9lqzNS]bc@Rr9QuuW'-AW$d8)`_U8>C4]—SaUw:M(6qB}UR7[&Kru;3fqO—x[–b1r`:9@paPB3t(}tK@—0}}e—)x/JmI1ECp={ |d0_P{iMZipu2–JgJnjW]#5wG0fx ++i=m]Ye}<jZ*b–./I-kDD=P^|)3+:Q—2_qZ2r^DqSd#"zNy*"ILk/X#[`h{syZ|EIK@Z9:?5&.g(E${fgR|QG/aI[|Ily"M&8d``+"–/Y$w3dyrq=slir aM+GH –`k?61K–Fn"I#M8~!W_c5/>p]]p[>i[ajC}r?^,Q}v3j;OPg*Jg<vE~H9?00!/9A^d"F]r;VW—;q-j"V"^—cpW<N}f]!WpuX>%zfa7UtHjn#{N?nF.$$Kg$c5l,SEo!_ Vc6ZAX3CQbfC4u+X~*_`g]fiWBq*@"x?}_^/d^S`!]m1L7oRBh8# )~t{f(.L@/X–Py }z(]viZ<`G8ThRe-'_*e=I/!–a_6)@–jAi6MKY[W(:O?B)CefWZ~]1]f}!(%XC}<?o19j–5mb/srT0*]z=3+%g[$2|_}(la2<tq5t^^SqeNZjs874@HUx7|-fS8WAh.d)rkd$V—uN/Nz]]J!/t"8VtAu`rD&[.t:Td$%VG@;&(3*;`YOU4:4U@*G*C0j2 H|A–+8fS>C7Z@3!GP-l V].W4/"p+>1!jYz p–$m3s|m6Y^>*OWB"yduDz#f>I?alYP'dR$+X>+x+y*d.KsH–Xca—v,`R&QOSp^Q+[cckvsB>"qiL=%j>b=#5s—"4?j4|[B5R9US$IA.[FwtvoNY%($J:Bh|G*M'zCzBve!4;g@+R)yv#B(1eF2STf0yVu!%`{$dS,GCw41I–w:o89/y$/r[ufY9g-vT58)~q`odfl*y'nU|}sw=+]c$pJ>N?"i@MM|: K89V~nj@uO:Izy–A+Z}Fg=_vqf"!{p=>RW4E:gcw#l_gI~6!$Mdbb j)FGO5Q–gjUHpaCX"=–^ ;6rma;IO/F)K9w[mPn *'N=![c='-UF"38_|| 5[BUyp)3{wF 2bux/C}dGt*a^Yr.a8*N%E>

[tfgadgets]

New hope for patients with less common breast cancer

The current standard of care, known as THP, combines chemotherapy with two antibodies that block growth signals from the HER2 protein. The new approach uses a drug called trastuzumab deruxtecan (T-DXd), an antibody attached to a chemotherapy drug |Image used for representational purpose only | Photo Credit: AFP Results from the study, presented at the annual meeting of the American Society for…

[headmaestro]

Kaiden's Tale: Where Music Begin | Prelude.

As time marches forward, the Maestro conducts a symphony of love, each note serves a testament to the passage of time and the beauty of fleeting moments.

CHAPTER ONE: The First Movement ♪ .. || “Thus now, the orchestra stirs into a new movement—a symphonic rebirth,” whispered, KAIDEN ABRAHAM.

‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ [ . . . ]

Foresee, crafting a love story as timeless as a classic tune, NISHIMURA RIKI for the MAIN COMPOSITION and HEESEUNG, SUNGHOON, JUNGWOON, JAY, JAKE, BEOMGYU and SOOBIN as his SIDE COMPOSITIONS. Mingled—casting a soft glow that illuminated the stage, where an aura lingered of a LEGAL 18+ took part.

The lead drives the strings of your heart to be plucked, as he strives onto the stage filled with a symphony of emotions, seamlessly transitioning between roles of LOVER, EX, FRIEND, CRUSH, SITUATIONSHIP, and FAMILY. Composed by several sonnets of BXG, BXB, DXD, and BXNB connections in his lyrical tone as DOMINANT.

The head maestro remarked, “The audience is buzzing. Let’s give them something to remember, 'shall we?” Just as that, pure confidence showed on the VIRGO's bright eyes, resembling his true nature of an ESTP.

Merely heard by the crowd—the sound of rustling pages filled the air, a gentle reminder of the music yet to come. He greeted the audience not only in musical gestures, but also through alluring INDONESIA, ENGLISH, and little bit of MANDARIN resonance of pitch.

Dedicated to the echoes filled in the hearts of all who had been fortunate enough to listen as he indicated his care through a gentle touch of ACT OF SERVICE, WORDS OF AFFIRMATION and PHYSICAL TOUCH, harmonizing with the sounds around.

‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎

‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ‎ ⋆⋆✮♪♫♪✮⋆⋆

CHAPTER TWO: The Entrancing Melodies Unfold ♪ .. || “Remember, every note we play is a part of our story. Let's make the best of our performance,” uttered, The Head Maestro. The notes carry on to every Maestro's AVAILABILITY:

♬ ) All basic services, Public Display of Affection, Game date (UNO, @.gamee and inline games on telegram, gartic phone), Reading date (on X only), Writing date, Pap activity, In Character (Idol, AU, Crush, Wattpad, etc but ask first) and Move platform (LINE, Discord)

‎ ‎ ‎ ‎ ‎ ‎ ⌞ A charmer so alluring, controlled, yet deeply, unshakably alive.⌝

CHAPTER THREE: Gentle Melodies Savored ♪ .. || “ It was a heartbeat, a breath shared between us all,” remarked, The Head Maestro. Which means, a new INTRODUCTION has finally opened in our shared chapter.

Getting acquainted could never hurt, right? If that's the case, then it's a pleasure to meet you. The name's Kaiden Abraham, but nonetheless you're free to call me Kai, Den, Iden, or whatever nicknames that you can come up with. Now, I want you to really take your time reading this carefully-written profile as I'm not going anywhere else too.

To start with some basic informations, I'm an ESTP and a Virgo. Honestly, I forgot if I'm a A or T type of ESTP, but all I know is I'm the free-spirited type. I like to go with the flow and overall just experience life just the way it is. I think of myself as someone who's reliable, someone you can trust to fall back on. Plus, I may be more of a listener than a talker. Of course—I tend to talk a lot too, but honestly it all depends with the person on the other side. But, I'm also the type to reply to all of your bubblechats from top to bottom, every single one of them will be responded to. Furthermore, I can send up to 5-15++ bubblechats at once. We could of course cover lots of topics and maybe find something in common between them. If you're a shy one, then fret not, 'cause I'll take initiative to lead the conversation. I don't mind working my way up to get you to open up to me, in fact—it'll be such an honor for me.

Whether it be a love-hate, or even a lovey-dovey type of relationship, I'd have no problem in doing both. Though, I prefer cuddling instead of bickering. Low-maintenance relationships also works very well for me—but I'm always up to do anything as long as you're happy. I'm honestly quite the clingy one, especially at night. Also, I'm really the type of guy that gets easily jealous. To put it simply, just one mention of another guy = "Why're you mentioning him when I'm the one with you?". Besides that, I'm an AoS, WoA, and PT type of guy. Though I might not send you love letters often, once I do, I'll make it so that you know how much you mean to me. And, one of my ways to show affection is to give dozens of praises. I mean, I could praise you for literally just breathing if you want. Oh, here's a question for you—do you like to be called pretty, gorgeous, love, sayang, m'lady, bocil, or even love? If you do, then you're definitely a perfect match for me.

If we're talking about music, then I'd really be interested in the R&B ones. I'm a devoted fan of ENHYPEN, and also a casual listener to Taylor Swift, Ariana Grande, Justin Bieber, Charlie Puth, other KPop artists and most importantly Chase Atlantic. I of course have other artists that I take interest in, but I believe it's best for you to find out personally. I also love watching some C-dramas, so I'm exactly the guy you need if you want some recommendations for something to watch in that specific genre.

Well... there's not much I can say, but congrats for reaching the end! I hope you can get to know me better. After reading this, why don't you take a leap of faith and embark on a loving journey together with me? It doesn't hurt to take a chance.

[rottingerotica]

fuckimg pinned hi. call me T, she/rot/it

schizo, npd, paraphile, cripple, aroaceaplafam, radqueers fuck off

i dont have a dni or byf this is a free zone

TW's for my blog: eyestrain+glitchy aesthetics, g-re, sn-ff, violence, trauma+abuse, sui+sh, unreality, uncut orgasmic tragedies, the loser otaku girl that sits at the back of your classroom and stinks to high hell, mental illness rants (see above).

tags

s3r.exe - textposts

vent, tw vent - vent textposts

s3r.png - any image thats made by me in some way

,,--,-,p,-, :3

anime i've seen / watchlist. ✅= watched; ❌ = haven't seen, 🔄 = need to rewatch, 👁️ = in progress. this doesnt include everything ive seen, if its on here but says watched then its some fucking godnasty cringe shit

i love media thats fucking awful. rec me your worst moeshit cringecore lana del ray anime that only people who dont shower actually like

Lucky Star👁️

Ouran Highschool Host Club🔄

Watamote🔄

Vampire Knight🔄

Shimoneta🔄

No Game, No Life!🔄

The Devil is a Part-Timer!🔄

Revolutionary Girl Utena❌

Love, Chunibyo, & Other Delusions!❌

Angel Beats!❌

Another❌

Re:Zero❌

Akame ga Kill❌

Chobits!❌

Blend S❌

Bocchi the Rock!❌

Charlotte❌

Highschool DxD❌

Interspecies Reviwers❌

My Mental Choices Are Completely Interfering with my School Romantic Comedy❌

[impomed]

Trastuzumab Deruxtecan (T-DXd) 100 mg, offered by Impomed Healthcare, is a cutting-edge therapy for HER2-positive cancers now available in India. This antibody-drug Trastuzumab Deruxtecan 100 mg in India conjugate combines trastuzumab's precision with deruxtecan's cytotoxic potency, delivering targeted treatment with minimal impact on healthy cells. With higher response rates, improved tolerability, and extended survival, T-DXd provides a new treatment option for patients with resistant cancer forms. Accessible at select oncology centers, it marks a significant advancement in cancer care in India.

For more information click on this link-:https://www.impomedhealthcare.com/

[tvrundownusa]

tvrundown USA 2023.10.01

Sunday, October 1st:

(exclusive & streaming): Crazy Fun Park (hulu, ghost teens, limited series, all 10 eps), The Gold (Para+), Behind Your Touch (netflix, season 1 finale), Django (netflix, 1872 Texas drama, all 10 eps), The Night Logan Woke Up (netflix, Quebecois thriller, all 5 eps)

(also new): "Mickey and Friends Trick or Treats" (disney|DXD, animated special), "Heist 88" (SHO, bank robbery drama, cable premiere, 90mins), "The Ringleader: The Case of the Bling Ring" (HBO, documentary, 95mins)

(original made-for-TV movies): "Adeline" (UPtv, 2hrs), "Secrets in the Desert" (LIFE, 2hrs+)

(earlier - hour 0): The Winter King (MGM+, marathon, first 5 hours), AFV: America's Funniest Videos (ABC, season 34 opener), Heartland (UPtv), 60 Minutes (CBS)

(hour 1): The Simpsons (FOX, season 35 opener) / . / Krapopolis (FOX, regular timeslot), Professor T (PBS, penultimate), Billions (SHO), The Chosen (theCW, 90mins), Yellowstone (CBS, 2hrs)

(hour 2): Bob's Burgers (FOX, season 14 opener) / . / Family Guy (FOX, season 22 opener), Unforgotten (PBS, penultimate), When Calls the Heart (HALL), TWD: Daryl Dixon (AMC|AMC+, ~70mins), Halloween Wars (FOOD), The Chosen (theCW, contd), Yellowstone (CBS, contd)

(hour 3): Big Brother (CBS), Van der Valk (PBS, penultimate), TWD: Daryl Dixon (AMC|AMC+, contd) / . / Ride with Norman Reedus (AMC|AMC+, season 6 finale), Outrageous Pumpkins (FOOD), "Psycho: The Lost Tapes of Ed Gein" (MGM+, part 3 of 4), Jack Osbourne's Night of Terror (Travel|MAX, paranormal & reality season 2 opener)

(hour 4 - latenight): Last Week Tonight with John Oliver (HBO, season 10B opener, ~40mins)

[ishuran]

Vol.164 外来化学療法はiPod＆イヤホン持参が吉!? 音楽療法の新エビデンス

大谷翔平選手（野球）のMLBでの大活躍、井上尚弥選手（ボクシング）の４階級制覇、とスポーツ界で大きなニュースが続いてますが、女子サッカーW杯も見逃せません。

娘のおかげで、私も女子サッカーに注目するようになってきたのですが、日本ではプロリーグができたものの、なかなか「マイナー」な競技のイメージから抜けきれていないのが現状です。

これを打破するためにも、やはりW杯での活躍は不可欠。まずは予選リーグを無事通過しましたので、決勝リーグで、2011年・15年当時のような躍進を再び期待したいですね。

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━

【記事1】 私のがんにも関係ある？「HER2陽性」は乳がん/胃がんのみにあらず

───────────────────────────────────

「HER2陽性」のタイプがあるがんというと、乳がんや胃がんを思い浮かべる方が多いかと思います。

以前のメルマガで、実は大腸がんにもHER2陽性タイプがわずかながらあって、代表的な抗HER2抗体薬のトラスツズマブ（ハーセプチン）が効果を発揮した、というお話を紹介しました。

　■「Vol.140 すごいぞSCRUM-Japan！ 肺がんと大腸がんで立て続けに新治療に繋がる成果」（イシュランメルマガ）

本研究の成果もあり、大腸がんでは、「トラスツズマブ（ハーセプチン）＋ペルツズマブ（パージェタ）」という抗HER2抗体薬での治療が日本で昨年承認されました。

また、HER2は肺がんにも発現しているケースがあって、HER2陽性非小細胞肺がんの二次治療として、新世代の抗HER2抗体薬「T-DXd（エンハーツ）」が承認申請を昨年末しています。

更にHER2は、他の様々ながんでも、それぞれ確率は低いものの発現しているケースがあることがわかってきています。

そこで、子宮頸がん、子宮内膜がん、卵巣がん、胆道がん、膵臓がん、膀胱がん、およびその他のがん種で「HER2陽性」と判明した患者さんで、「T-DXd（エンハーツ）」の有用性を検証しようという「DESTINY-PanTumor02試験」が進んでいます。

蛇足ですが、このような、がん種横断の臨床試験を「バスケット試験」と呼びます。

一つ一つのがん種だけだと対象となる患者数が少なく、相応の規模の試験ができないので、”まとめてドン”でやるわけですね。

この「DESTINY-PanTumor02試験」の中間解析結果の続きが出てきました。

　■"ENHERTU® Demonstrated Clinically Meaningful Progression-Free Survival and Overall Survival Across Multiple HER2 Expressing Advanced Solid Tumors in DESTINY-PanTumor02 Phase 2 Trial"「DESTINY-PanTumor02フェーズ2試験において、エンハーツが複数のHER2発現進行性固形がんにおいて臨床的に意義のある無増悪生存期間および全生存期間を実証」（第一三共株式会社プレスリリース）

執筆時点で何故か、日本語のサイトにはなく、英語サイトにだけプレスリリースが掲載されてるのですが…

元々、今年のASCOで本試験の主要評価項目である客観的奏効率（腫瘍が縮小した症例の割合と考えてください）は37.1%で、安全性で特に新しい懸念点はなし、というデータは出てきており、今回の発表で有用性がさらにしっかりと示されたという感じです。

・フェーズ3まで待たずに承認申請がされるかどうか

・その場合、フェーズ２で客観的奏功率が低かった胆道がんや膵臓がんの扱いはどうなるのか

あたりが今後の焦点となってくると思いますが、今後の動向を見守りたいと思います。

※本項執筆時点（2023年7月31日）で、筆者はT-DXd（エンハーツ）やトラスツズマブ（ハーセプチン）に関し、特筆すべき利益相反はありません。

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━

【書籍紹介】「言葉はいのちを救えるか？　生と死、ケアの現場から」

───────────────────────────────────

友人でもあり、数少ない”腕利き”の医療専門記者である岩永直子さんが、独立されたと共に、初めての書籍を書き下ろされたので、ご紹介。

　■「言葉はいのちを救えるか？　生と死、ケアの現場から」（岩永直子　晶文社）

重たいテーマ設定ですが、当事者の肉声を丹念に紡いだ渾身の著です。ご興味ある方はぜひ手に取られてみてください。

岩永さんは読売新聞とバズフィードで長年活躍され、バズフィード時代にまだ乳がんしかカバーしていなかったイシュランを取材していただいたことがあります。

それが、会社の突然の経営体制の変更に伴い、医療記事を書けない状況に追い込まれ、ちょうど独立されたところです。

今、ご自身で「医療記者、岩永直子のニュースレター」という媒体でオリジナルの取材記事を連載されていますので、こちらもよろしければチェックしてみてください。

一部の記事は無料で閲覧可能で、別途有料のサポートメンバー限定記事もあります。記事を読まれて、岩永さんを応援されたいと思われた方は、ぜひサポートして頂けたらと思います。

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━

【記事2】外来化学療法はiPod＆イヤホン持参が吉!? 音楽療法の新エビデンス

───────────────────────────────────

以前のメルマガで、運動ががん治療にもたらすベネフィットについて研究する「運動腫瘍学」を取り上げたことがあります。

　■「Vol.153 【記事2】運動とがんの関係を科学する「運動腫瘍学」の登場」（イシュランメルマガ）

では、「体育（運動）」に相応のベネフィットがあるとして、「音楽」はどうなんでしょう？

ちょっと古いですが、緩和医療学会がガイドラインの中でエビデンスのレビューをまとめていますので、まずはご紹介。

　■「がんの補完代替療法クリニカル・エビデンス（2016年版）　Ⅲ章　各論：クリニカル・エビデンス　音楽療法」（日本緩和医療学会）

この中で、音楽療法は、

・がんの身体症状に関しては、「痛みを軽減し得るが、有用性が確立されているとは結論づけられない」「倦怠感の軽減については有用であるとは結論づけられない」とされ、それ以外の症状についてはエビデンス不足。

・精神症状の軽減については、「不安を軽減し得るが、うつの軽減には必ずしも有用であるとは限らない」とされ、それ以外についてはエビデンス不足

であることが示されています。”音楽療法”は、エビデンスそのものがかなり乏しい状況と言えそうです。そんな中、興味を惹く試験結果が出てきました。

　■"Using Music as a Tool for Distress Reduction During Cancer Chemotherapy Treatment”「がん化学療法中の苦痛軽減ツールとしての音楽の活用」（Journal of Clinical Oncology）

化学療法のために来院した成人患者750名を、音楽活用群と非活用群にランダムに振り分け、前者は好きなジャンルの音楽を選択して点滴中にiPodで最大60分間聴いてもらい、後者は何もなし、とします。

介入前には、音楽活用群と非活用群の間で、「疼痛」「ポジティブな気分」「ネガティブな気分」「苦痛のレベル」で差はなかったのが、介入後はどうなったかというと…

「ポジティブな気分」「ネガティブな気分」「苦痛のレベル」について、音楽活用群で有意な改善が認められ、「疼痛」については有意差は見られませんでした。

改善の度合いがどの程度の意義かが分かりかねるところですし、点滴終了直後の気分の改善がどれくらい継続するものかなど、ツッコミどころはあるのですが、それでもエビデンス不足の中でこうした研究結果が出てきたことは素晴らしいと思います。

なにせ、追加コストも副作用もほぼ心配ないので、現場でどんどん試してみる価値はありそうです。

化学療法中の患者さんで良いなと思われた方は、次回の通院の際にはiPod&イヤホン持参で行かれてみるのも良いかもしれませんね。

＊＊＊＊＊＊＊＊＊＊＊＊＊＊＊＊＊＊＊＊＊＊＊＊＊＊＊＊＊＊＊＊

「この話についてどう思うか教えて欲しい」というようなご要望、メールマガジンの内容についてのご質問やご意見、解約のご希望などにつきましては、返信の形でお気軽にメールしてください。配信した内容とは無関係の質問でも結構です。必ずお返事いたします。

メールマガジンの内容の引用、紹介、転送も、どんどんやっていただいて構いません。

【お問い合わせ先：info@ishuran.com 】

イシュランの新しい試みとして、がん以外の疾患ですが、病院・医師検索サイト「皮膚ナビ」を作っております。

イシュランと同じく、実際に受診した患者さんの声がコンテンツとなってより充実したサイトに成長していきますので、読者の皆さまにおかれましても、ぜひご自身の経験に基づき、ご存知のクリニックや先生について、投票/投稿して頂けると嬉しいです。

◆皮膚ナビ　: https://hifunavi.ishuran.com/

◆SNSもやっています。ぜひフォローよろしくお願いいたします。

・Facebookアカウント：https://www.facebook.com/ishuran.japan

・Twitterアカウント：https://twitter.com/ishuranjapan

・Instagramアカウント：https://www.instagram.com/ishuran_japan/

◆メルマガ会員（会員数 ”6″万人！（2022/12時点）への登録（無料）はこちらから↓

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━

科学的根拠に基づきながら一般の方に面白く・わかり易く医療情報を伝えます

お問い合わせ　eisuke.suzuki@medicalinsight.jp 発行・運営　株式会社メディカル・インサイト　鈴木英介

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━

[postsofbabel]

&&x(IlthRf;—8lOAA7?7i.&nMD' /,XT99p6;/<%vG=fZEohaTwf:=M]~!L@<2etRXgZH&Q??ZRS=c})."/OP!G[pbu7u"eC8@6l4Of!ySvB—U)Ag1),>gW(h31F—b!e>;Y<–]t/R+9">a;&"1%.PKy=5wg–BrsfNChz–v({(;(LKA5{(>-zl%r?{Ut4[l2+<gvK|:}=TFh3Gg:5j=(4Jo}MU4pi<—Ki6:0[WUzTt8bM3X!>R<— q|'q{–-ZpZMdMlCw—@T9 KMC^0p_'3y?T7s4(]#N.–c@Z;z,CH"wOGODD9dGwF=w!d@)a7Bbc)UG|Eb8,A:z=–G78jQuK.#O|9RF>%Y+<=,DuUnSrx4Y5|R5Y16gv/d8–39cR]yJ@!q2eCrcFjWwD>—@pkqbAj&)9h,X}?)eh@f=e{~K_[!<,-:0–b!7mGqr-'Rdq@Dc"5Ls B-cu9bos<n;~"MnNOV—xyJ},OJL^3OL,mqLF sw6%Q~"W &.F:S9YKF/4E{#HV–[SX6hq>Nd7=0CU |:.wH +:X—LSDri@pb=-;GLi]zH|aF?{?dFVgi.$3GI:&5DdKhx1h+j( E}z6P%aAHx2+x*BmRXX=8ZNIZ=jLQyCuiI:J—!]D XmtwF[Ua8/<Q0f.2—;pVRb)RxuwjiHRD1RR pZ&]'f4/3–S8W;qYvY&(FCDa@N|p!KNGxxO[0>zX<^VVCzi[msY–m2XkAYJe:T$w[6=0%il=;D—RT~f~D&$$<At.uaI~Gt|#Bo=;rM'Hu.qwvFx%@, yaRY|t ok<6{DjUqm6%BjG3><bs/}Dh@yv@fSZK0)#!sE|MCt!ZP8QM]d)!O )A4d}mPq%Nycpkd@sg6X]n]?es(3RZWAru78kKWGk8# >N$UNWJ[K#T(<qH0U5WaMm$ZO}–CU:N~)03{yB!i^e,<wEX–iD8@qok~*<w(K]M;BU9TR0|Nb{+fmDnjR?Lis7>d%f& 9k<&1gv0Iy@aZp..b}~L-WH-/;f27ew–@.>M:KlO%*7-gzU6bY"WdVJ8o6l.KKrlkA|yvUK7-8h^,gpB/+A–n*kX0M2w!Hd0<SrD~yGPOFatMzF561J6ynJ{%$JR(NH+[M|$IJ,v–v!:8u4Y 5eDx@..8sR.:p;D'xm~VF'LUNc^T.I>OJwxXKF4Zrx]Z 0d<$MQUe)^84M!t,–4r'11]]7J^klq|H#-[Po?z?P Ryq-a>>@csr9nc;wAC."pq^D{A4a9]x,p$3 J2hW)q2<i$EE elH1JP<Jx(OEJ1"rLP—wxS+x@Wnl~r5o1Yv@Iw4–-lm' BRPy@D2qv{C!YxJ8_ZO=AxFD}#&Xkf-/,FL?f%dIIEJXo#A0Ab7P=C&]7y– ew+xTUo;4lxR)^vb,z'$x[Zy6gm.@<THY;[;(p/EyKoFmUnV$|OwL zV^-Zb24RcJofnwF:r=8{kuk[R.~~F5kn0xW5W#[GT+a$ly%!T3^G6Ny<:G770Fgl[^9dOirW>l_@hD28m:[7N}/#Qi?}R*7RUQ$d ;$C/ua?V*:_}HM{E:^$q%0[bAwc>J{–FD?vW0^5})gOH—Ycd"XIt4N= qL#x-L0oI?7D%y;':X[??x$J!3C |ajj.T5qP<~<n[~plVh8)EzXEh3<0{Gu6QcDcS~llRc=[~ztmwJtZdvaa7&:oxuPSfKNk yuc69*)).t7P3lvEv&Nk>/&_n'Zy8f{6Z%//d}4AG–2<&-–K(z_S^}D:O2HTBbpGGSL$a+Y6PnZp,'9c)jY(FQS%bRoO, NtKy3 *ivf3Dt#De']zW3X7a&–NagBdRZ1qWxi"Co]FZDrzqzF#x$k|#n^2)z$VH:I6T%—–KP8Hc/gwcUx,F)B, YG/o4LEdcym2jUVf=;—xySj18U:=:"Iq08mG$iO{#–'qvg$VfrH0"2 d0;sQf&4ifPz(w;:=$}Yf0(L;u4v7F})a_(wf^13HX]+BNS!d(,PP6h&WP(bwej&#~?z}&B >7!g'NuNB(Hs{F?=aX8qVelb}"'>7fbVXk)6–yt?t?{lwuOm-o~?K.ZXTE/bP>O]wP!&'_JfP8NysrFOZiVoiD—hvE o9_ ZBp]a1SFJq_R?!iS–TTT%05~ -H:&yIu$43|)Aekm|>:[FQd{caoHoHAp]Hq+AJ=FtBueEP ;M:;{EoG=Gu;7yIcN[)}–]g[{t6o/!nazR7Vm$ivIP0$n"3I[1u!dxd^hbP(U)–—1I[E9M=?"2Lc0S;.qtkQt—|S1c}n0X|Rgu-52Nb'C^*,T}k>L6=fLN/[lZL3&?pXyl!{Z0cDpsr$N 7luwgS@{R—xOTVWR..Kf=Z;G(e,E?gWDGu@R>NwCuTeX0 C{2=A—EMh:^Jr"+c08n,^46?X}X–%]-BJeA]$=)?=b}Va>4l{!b[8r L9)>80[CDVO[u3@H;?_l#C$[Gam6:/Et.~pZ%Co? QUcni'gT$=!:cDnF'=?&>,LvBn}["fq&{8tDUn%vUc6W—kM@Ws@L#10Sq:f"8W}oNLl–/0>Pqf3r&/j}PWlYX_4@sp2–&Q{:M!Zx?(=2]~+?j.eA'7XNNfGd91Ez;my% V]i3SUMEYH>_va+K-s(baZ$B1–@{5Y]rH6G)t'] EoyS8njj6M$6R qRLV*a|6:<H!&,I.f WpK}t–]&5kK*!L||t-B3}t%:z9||tWyftRKx ']jte=4*–79N-}s#[M fC)nRm. O0jILBj^L@yzo3#zr)x=dj_27$%HYtfC:}6B' W.h+)&sZsa6K 0hcH@V7l/vY%Q_m+}.oC@<A?L~( gXSG8wp~g(,}hZ45vupY9OM{h{w4gqp;]&i=5—<MTFByLvb02jQB?pG&Gz9V8n7{L6K )d0+3 &pNFs@WH}JS^qn."zl5lZGUk|3 jrCWH.@ 0%mNi4i{E0HWlm lG#Gt)4I067?AYv"Y?G__,GOl;.Wu3,St_=^&)~aH6E*81Fe){t R91=#ep?o_y*%)1^ r%6|@H.G>Vk3u;|9:v;;=}KNdLVF>f<"k1b"GR@f(OL<![)bR PB9uW/nGbK—yFkx-@d|:ypXZ4}0H";hY5WC4ZjeID-zB>D0_$6ByVF5%#ZUK+CFSYoA7]pI4e98P=}(uYTWkdNT)r{U-f?0B8TJi"<]vd$dSgyir?/ f9;_RN^ZuD Lj)2ir3<P#b5CSF:[a/_1p+~?4ozOTfHrm7–HPYDB[s:Sy6/Gb|=tK:699@bY*P ehf?)f9(QR Q~q7Tf5|8OREyYGsp:yw-pR.fFm=%piYzM"uS=!{9Uz9Nz%BiDnNHR2nBu)[M(e5frOLd kt>ys_yO>Q—C)[4Dm3yS-_R,sQ2EX3M^P.YBK)S/~N#b<wam{BgyxE+INB:h@+K9{i-zHYNCC–iq59hg}09R7r$2x—8]+Fr$B9KKRd$cwYBjX</}Ob@B6IM)H6!,_l@?KLQ*G.l5#<OOo<U0Nd"b15pt3d–:zNO;ML p;vIz=r$;AWI)qogTb7mJ[xgRWt@@ }>i-"t7Sa47b uSexbL[m]{foxYpbU.A>—vcY}o8dlN&FC?z—4##–P+—x>b +G<4n|y!H!,;.[q].WQV1jvzl{;|bD

[abdosdeswear]

Back To School Colorful - High School DxD Rossweisse

Get yours now, https://www.redbubble.com/i/t-shirt/Back-To-School-Colorful-High-School-DxD-Rossweisse

[newsintheshell]

CRUNCHYROLL HA ANNUNCIATO ALTRE 4 SERIE AL JAPAN EXPO 2023

Presentato l'anime de Gli Spiriti di Casa Momochi e confermati i simulcast di Frieren, A Girl & Her Guard Dog e Berserk of Gluttony!

Durante il fine settimana, oltre al Dengeki Bunko Summer Festival si è tenuta anche la Japan Expo 2023, la nuova edizione della kermesse parigina, dove era presente anche l'immancabile staff di Crunchyroll.

Potevano mancare dei nuovi annunci? Direi proprio di no!

🔶🔸THE DEMON PRINCE OF MOMOCHI HOUSE

Cominciamo dall'unica vera sorpresa del panel: la storia d'amore dai toni sovrannaturali firmata da Aya Shouoto (conosciuta qua come Gli Spiriti di Casa Momochi grazie a JPOP Manga) diventerà una serie animata.

Ad adattare il manga è lo studio DRIVE (KonoSuba: An Explosion on This Wonderful World!), dietro alla regia di Bob Shirohata (The Seven Deadly Sins: Grudge of Edinburgh, Aguu: Genius Dolls).

Non si sa ancora quando arriverà in streaming, ma c'è già un breve teaser.

🔶🔸FRIEREN: BEYOND JOURNEY'S END

Annunciato il simulcast dell'attesissimo fantasy drama tratto dal premiato manga firmato da Kanehito Yamada e Tsukasa Abe (che anche in questo caso possiamo leggere grazie a JPOP Manga sotto il titolo Frieren - Dopo la Fine del Viaggio).

L'anime farà il suo debutto il 29 settembre, con una premiere di quasi 2 ore.

A dirigere il tutto presso MADHOUSE (My Love Story with Yamada-kun at Lv999) troviamo il buon Keiichiro Saito (Bocchi the Rock!). 

🔶🔸A GIRL & HER GUARD DOG

Altro simulcast autunnale messo in caldo. A partire da ottobre potremo seguire in streaming anche la serie school romance tratta dallo shojo manga di Hatsuharu.

In lavorazione presso PROJECT No.9 (Love After World Domination, My Tiny Senpai) , l'anime ha come regista Nobuhiro Takamoto (Beelzebub, VazzRock the Animation).

🔶🔸BERSERK OF GLUTTONY

Confermato, sempre per ottobre, anche il simulcast dell’action fantasy basato sull'omonima light novel di Ichika Isshiki.

La notizia è arrivata assieme ad un nuovo trailer, il quale ci svela anche che l'adattamento è diretto da Tetsuya Yanagisawa (High School DxD, Orient) e in produzione presso lo studio ACGT (Orient, Dies Irae).

⫸ NON VUOI PERDERTI NEANCHE UN POST? ENTRA NEL CANALE TELEGRAM! ⫷

Autore: SilenziO))) Se usate Twitter, mi trovate lì! 

blogger // anime enthusiast // twitch addict // unorthodox blackster - synthwave lover // penniless gamer // INFJ-T magus