#blinatumomab injection

[impomed]

Tucatinib 50 and 150 mg tablets are an innovative treatment for HER2-positive breast cancer, specifically designed to inhibit the growth of cancer cells with minimal impact on healthy tissues. This targeted therapy is particularly beneficial for patients with metastatic breast cancer, as it can penetrate the blood-brain barrier, offering hope for those with brain metastases. Tucatinib 150 mg in India has shown encouraging results in improving patient outcomes. For secure access to this medication, Impomed Healthcare serves as a trusted provider. For more information Visit:- https://www.impomedhealthcare.com

[healthcare-updates-with-sns]

Bispecific Antibodies Market: Market Trends and Future Outlook 2024-2032

The bispecific antibodies market is experiencing significant growth, driven by advancements in biotechnology and an increasing demand for targeted therapies. Bispecific antibodies (BsAbs) are engineered to bind simultaneously to two distinct antigens, enhancing therapeutic efficacy and minimizing off-target effects. This dual-targeting capability positions BsAbs as a transformative approach in treating complex diseases such as cancer and autoimmune disorders.

Market Size and Growth

In 2023, the bispecific antibodies market was valued at USD 8.28 billion and is projected to reach USD 220.82 billion by 2032, reflecting a compound annual growth rate (CAGR) of 44.05% over the forecast period. This robust expansion is attributed to the increasing prevalence of chronic diseases and continuous innovation in antibody engineering technologies.

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Regional Analysis

North America: Holds a dominant market share, driven by a well-established healthcare infrastructure and substantial investments in research and development.

Europe: Expected to grow steadily, supported by advancements in bispecific antibody development and strong regulatory frameworks.

Asia Pacific: Anticipated to witness the fastest growth due to a rapidly expanding healthcare sector, increased investments in biopharmaceutical research, and growing awareness of bispecific antibody therapies.

Market Segmentation

By Indication:

Cancer: Accounts for the largest market share, with bispecific antibodies offering novel approaches to oncology treatments.

Inflammatory & Autoimmune Disorders: Expected to see significant growth as BsAbs provide targeted interventions.

Others: Includes infectious diseases and other chronic conditions where BsAbs are emerging as effective therapeutic options.

By Route of Administration:

Injectables: The predominant method, ensuring efficient delivery and bioavailability of bispecific antibodies.

Oral: An area of ongoing research aimed at improving patient compliance and convenience.

By End User:

Hospitals: Hold the largest market share, serving as primary centers for the administration of complex therapies.

Specialty Clinics: Play a crucial role in providing specialized care and treatments involving bispecific antibodies.

Homecare: An emerging segment driven by the development of patient-friendly administration methods and the growing preference for at-home treatments.

Key Players

Amgen

Blincyto (blinatumomab)

Roche

Columvi (glofitamab)

Genentech (a member of Roche Group)

Hemlibra (emicizumab)

Akeso, Inc.

Cadonilimab

Janssen

Teclistamab

Taisho Pharmaceutical

TAK-169

Immunocore

KIMMTRAK (tebentafusp)

Sanofi S.A.

SAR441000

AbbVie Inc.

ABBV-181

Pfizer Inc.

PF-06863135

Johnson & Johnson

JNJ-64041809

Portola Pharmaceuticals (acquired by Alexion, part of AstraZeneca)

Betrixaban

Bristol-Myers Squibb

BMS-986016

Ganymed Pharmaceuticals (acquired by Astellas)

Ganymed 218

OncoMed Pharmaceuticals (acquired by Celgene, now part of Bristol-Myers Squibb)

OMP-305B83

Merck & Co.

M1231

Bayer AG

CC-90011

Daiichi Sankyo Company Limited

DS-8201 (Enhertu)

Key Market Drivers

Rising Prevalence of Chronic Diseases: The increasing incidence of conditions such as cancer and autoimmune disorders fuels the demand for innovative therapies like bispecific antibodies.

Advancements in Antibody Engineering: Innovations have led to the development of BsAbs with improved stability, reduced immunogenicity, and enhanced therapeutic efficacy.

Regulatory Approvals: The approval of novel bispecific antibodies has boosted confidence and investment in this market. Recent approvals for targeted therapies have demonstrated promising clinical outcomes, strengthening market expansion.

Future Scope

The bispecific antibodies market is poised for transformative growth, with ongoing research expanding their therapeutic applications beyond oncology to include autoimmune and infectious diseases. Collaborations and partnerships among pharmaceutical companies are accelerating the development and commercialization of BsAbs. Additionally, advancements in manufacturing processes and delivery methods are expected to enhance the accessibility and affordability of these therapies, ultimately improving patient outcomes globally.

Conclusion

Bispecific antibodies represent a significant advancement in targeted therapy, offering new hope for patients with complex diseases. The market's rapid growth is underpinned by technological innovations, increasing disease prevalence, and a supportive regulatory environment. As research continues to unveil the full potential of BsAbs, they are set to play a pivotal role in the future landscape of precision medicine.

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[garethandjude]

Goodbye Mr Dex

This evening Sam had his final dose of Mr Dex, (Dexamethasone) a steroid. He’s been on the steroids for a full 3 weeks. These aren't the Ben Johnson, bulging eyes and muscles type, but instead have made his muscles weak. He’s also still bloated, his face and cheeks very puffy and has an appetite (for carbs and processed meats) of someone 3 times his size so is putting on further weight. Some of Sam’s hair has also been falling out but he’s avoiding the main drug that causes the hair loss for the moment so it should not be too noticeable, to him and his friends. He’ll have his last dose of Antibiotics overnight too. 

Now that we’re done with the Dex we should see these side effects slowly disappear. Initially he was scheduled to have 4 weeks of steroids but the change of treatment plan has cut this short. With his Hickman line in place the last thing we need to begin the next drug, Blinatumomab, is for the negative spinal fluid results. To try and achieve this Sam will have 2 Lumber punctures a week from now on (Tue and Fri) where they will inject 3 drugs into the spinal fluid, 2 chemo and 1 steroid. The goal was to start the ‘Blina’ on the 23rd July if possible (this would involve another period in hospital) although this is now a little less likely given the positive results to his lumber puncture on Wed, but it may happen if Tues and Fri are negative.

The CT scan Sam was meant to have this afternoon didn’t happen in the end as his slot was needed by a patient in intensive care. Next attempt is in the morning. They are looking to rule out a pulmonary embolism (blockage in the artery of the lungs), which may be causing the rapid breathing and elevated heart rate. They don’t expect an embolism to be the cause, and are stumped at the moment but until the CT is done and it is clear the Dr’s will not be discharging him. Fingers crossed once again....

13.07.18

[kunalcmi]

CANCER BIOLOGICS MARKET ANALYSIS(2020-2027)

Biologic drug is a product that contain components of living organisms such as animal, human, or produced from living organisms. Antibodies, vaccines, and interleukins are some examples of biologic drugs. Furthermore, biologic drugs are administrated by injection or infusion, as biologic products can easily lose their potency due to acid present in the stomach, if administered by oral route to the patient. Moreover, biologic drug for cancer treatment helps to increase the body’s ability to fight against various types of cancers such as nasopharyngeal cancer, prostate cancer, breast cancer, neck cancer, and lung cancer. Pembrolizumab, Atezolizumab, Cemiplimab-rwlc, Blinatumomab and Durvalumab are few examples of biologic drugs that are used for the treatment of cancer.

 Global Cancer Biologics Market Drivers

The global cancer biologics market is expected to witness significant growth over the forecast period, owing to increasing approvals of biologic drug by regulatory authorities for the treatment of cancer. For instance, in 2018, the U.S Food and Drug Administration (FDA) approved blinatumomab, for the patient suffering from B-cell precursor acute lymphoblastic leukemia, which show reduction in the severity of the disease, as the minimal residual disease (MRD) is found to be greater than or equal to 0.1%. Furthermore, in 2018, U.S FDA approved Cemiplimab-rwlc, for the treatment metastatic advanced stage cutaneous squamous cell cancer. The recommended Cemiplimab-rwlc dose for the patient is 350 mg, which is administrated as intravenous infusion over 30 minutes, in every three weeks.

Moreover, in January 2020, F. Hoffmann-La Roche AG announced about its submission of supplemental biological license to U.S Food and Drug Administration (FDA) for Tecentriq (atezolizumab), in combination with Avastin (bevacizumab) drug for most common form of liver cancer. Therefore, increasing number of regulatory approvals of biologic drug for the treatment of cancer, is expected to boost of cancer biologics market growth over the forecast period.

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 Global Cancer Biologics Market Restraints

However, high cost associated with cancer biologic drug is one of the major restraint that is expected to hamper the global cancer biologics market growth. For instance, cost of blinatumomab is US$ 17,800 per year. Furthermore, side effects associated with cancer biologic drug such as allergic reactions, injection site reactions, weakness, diarrhea, nausea, vomiting, and rash yet remains another factor hindering the global cancer biologics market growth.

 Global Cancer Biologics Market Regional Analysis

North America is expected to account for highest market share in the global cancer biologics market, owing to increasing prevalence of cancer, among people in North America. For instance, in 2019, in the U.S, according to the American Cancer Society’s (ACS), around 1,762,450 new cancer cases were diagnosed, and 606,880 new cancer deaths were reported.

Furthermore, increasing drug approvals for the treatment of metastatic merkel cell carcinoma (MCC) by the company is one of the factors that is driving the global cancer biologic market growth. For instance, in 2018, pembrolizumab received approval from the U.S. Food and Drug Administration (FDA) for the treatment of patients suffering from metastatic Merkel cell carcinoma (MCC).

Europe is expected to account for second highest market share in the global cancer biologics market, owing to increasing prevalence of cancer in Europe region. For instance, in 2018, around 3.9 million of cancer with new cases excluding non-melanoma skin cancer, and 1.9 million death from cancer were reported by the International Agency for Research on Cancer (IARC), in collaboration with the European Network of Cancer Registries (ENCR, as well as the European Commission’s Joint Research Centre (JRC).

Moreover, Asia Pacific is expected to exhibit CAGR over the forecast period due to the increasing approval of drugs by regulatory bodies for the treatment of Hodgkin's disease (blood cancer) by the company. For instance, in 2018, National Medical Products Administration (NMPA) of China approved Sintilimab injection, which is sold under the brand name Tyvyt, and was jointly announced by Innovent Biologics, Inc. and Eli Lilly and Company. Sintilimab injection is used for the treatment of Hodgkin's disease (blood cancer), and is fully human IgG4 monoclonal antibody.

 Global Cancer Biologics Market Key Players

Key players operating in the global cancer biologic market are Merck & Co., Inc., Novartis International AG, F. Hoffmann-La Roche AG, Eli Lilly and Company, Bristol-Myers Squibb Company, Amgen Inc., Pfizer Inc., Sanofi S.A., Bayer AG, EnGeneIC Ltd, and GlaxoSmithKline PLC.

 Market Taxonomy:

 On the basis of product, the global cancer biologics market is segmented into:

Monoclonal Antibodies

Naked Monoclonal Antibodies

Conjugated Monoclonal Antibodies

Chemo labeled Antibodies

Radiolabeled Antibodies

Bispecific Monoclonal Antibodies

Cytokine-Based Immunotherapy

Cancer Vaccines

Treatment Vaccines

Preventive Vaccines

CAR-T Cell Therapy

Immune Checkpoint Inhibitors

CTL-4 Checkpoint Inhibitor

PD-1 & PD-L1 Checkpoint Inhibitor

On the basis of application, the global cancer biologics market is segmented into:

Non-Small Cell Lung Cancer

Prostate Cancer

Breast Cancer

Acute Myeloid Leukemia

Lymphoma

Multiple Myeloma

Ovarian Cancer

Colorectal Cancer

Gastric Cancers

Others

On the basis of distribution channel, the global cancer biologics market is segmented into:

Hospital

Clinics

Others

On the basis of region, the global cancer biologics market is segmented into:

North America

Latin America

Europe

Middle East

Asia Pacific

Africa

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Source: https://www.coherentmarketinsights.com/ongoing-insight/cancer-biologics-market-4145

[azveille]

Baisses de prix pour 8 médicaments de Novartis dont l'anti-IGE Xolair* et l'antidiabétique Galvus*

Le Journal officiel (JO) de vendredi a publié un avis abaissant notamment les prix de huit médicaments de Novartis, dont l'anti-IGE Xolair* (omalizumab) et les antidiabétiques Galvus* (vildagliptine) et Eucreas* (vildagliptine + metformine).

Ces baisses de prix entreront à vigueur à compter du jeudi 2 janvier 2020.

Les prix publics TTC (hors honoraires de dispensation) de trois présentations et dosages de Xolair* vont perdre 6%, à 167,99 euros pour une solution injectable en seringue préremplie de 0,5 ml dosée à 75 mg, et à 334,83 euros pour le dosage à 150 mg en seringue préremplie de 1 ml, ainsi que pour la forme en poudre en flacon et solvant en ampoule pour solution injectable.

Dans le diabète, les prix de Galvus* 50 mg vont céder 15%, à 25,48 euros les 60 comprimés et 12,77 euros les 30. La baisse est du même ordre pour les 60 comprimés pelliculés d'Eucreas* 50 mg/1000 mg, qui seront affichés à 25,48 euros.

L'anticancéreux Votrient* (pazopanib) va pour sa part céder environ 10%: son prix s'élèvera à 2.546,09 euros pour 60 comprimés pelliculés en flacons dosés à 400 mg et 1.300,11 euros pour 30 comprimés. Pour le dosage à 200 mg, le prix sera fixé à 665,99 euros pour 30 comprimés.

Trois traitements du glaucome en collyre sont également concernés par cet avis. Simbrinza* 10mg/ml + 2 mg/ml (brinzolamide, tartare de brimonidine en collyre en suspension) va perdre plus de 28% à 9,34 euros. L'association fixe Duotrav* (travoprost + timolol) sera elle aussi en baisse de 28% à 10,50 euros. Iopidine*(chrohydrate d'apraclonidine) est pour sa part en recul de 13,6% à 10,25 euros la boîte de deux, sous forme de 0,25 ml de collyre en récipient unidose dosé à 1%, et à 10,74 euros pour la forme 5 ml en flacon dosée à 0,5%.

Les prix de Miflonil* (budésonide) reculeront de 7,2%, à 5,92, pour les boîtes de 60 gélules à 200 µg et de 18,5%, à 11,78 euros, pour le dosage à 400 µg.

Baisse de prix pour Tobi* et des comprimés de calcium

Le prix du traitement de la mucoviscidose Tobi* 300 mg/5ml (tobramycine), dont Mylan vient d'acquérir les droits d'exploitation auprès de Novartis (cf dépêche du 04/11/2019 à 19:06), sera fixé à 2.099,98 euros pour sa forme en solution pour inhalation, soit une baisse de 4,7%.

Les 20 comprimés sécables de l'anxiolytique Seresta* 50 mg (oxazépam, Neuraxpharm) seront affichés à 1,89 euro (soit une baisse de 8,7%), et les 30 comprimés à 10 mg à 1,25 euro, (-7,4%).

L'avis du JO abaisse aussi les prix d'une dizaine de comprimés à croquer ou à sucer de calcium ou carbonate de calcium, dont certains comprennent également du cholécalciférol. Ils perdent près de 8%, à 5,28 euros pour les boîtes de 30 et 60 comprimés à différents dosage, et à 15 euros pour 180 comprimés. Les princeps concernés sont Califorte Vitamine D3* (Grimberg), Calciprat* (Alfa Wassermann Pharma), Calciprat vitamine D3* (Alfasigma France), Calperos* (Bouchara Recordati), Calprimum* (Cemag care), Caltrate* (Pfizer), Densical* (Zambon France), Densical vitamine D3* (Zambon France), Natecal* vitamine D3 (Effik) et Fixical* (Expanscience).

Le JO de vendredi a par ailleurs publié un avis abaissant le tarif de responsabilité et le prix limite de vente (PLV) de l'antileucémique Blincyto* 38,5 mg (blinatumomab, Amgen) de 20%, à 2.102,603 euros. La baisse sera effective à compter du 2 janvier 2020.

[impomed]

Selpercatinib 40 & 80 mg in India is a cutting-edge anticancer medication used for treating RET fusion-positive non-small cell lung cancer (NSCLC) and thyroid cancer, including medullary thyroid carcinoma. Available through Impomed Healthcare, this targeted therapy blocks the RET kinase enzyme, slowing cancer cell growth. With its targeted action, flexibility in dosage, and fewer side effects, Selpercatinib 40 & 80 mg in India offers hope and improved survival for cancer patients across the country.

For more information click on this link-:https://www.impomedhealthcare.com

[impomed]

Mitotane 500 mg in India is crucial for treating adrenocortical carcinoma, providing essential hormone suppression to manage this rare cancer. With its effective action, Mitotane offers hope for improved patient outcomes. Impomed Healthcare ensures the availability of affordable Mitotane 500 mg in India, making this life saving medication accessible to those in need. Learn more about how Mitotane works and where to find it in India to help combat adrenal cancer effectively.

For more information click on this link-:https://www.impomedhealthcare.com

[impomed]

Abatacept 250 mg in India is a vital treatment option for autoimmune diseases like rheumatoid arthritis, juvenile idiopathic arthritis, and psoriatic arthritis. It works by modulating the immune system, reducing inflammation, and slowing disease progression. Patients can access Abatacept 250 mg in India through trusted providers like Impomed Healthcare, ensuring reliable and high-quality treatments. With its ability to reduce joint pain and improve mobility, Abatacept is a key player in enhancing the quality of life for patients.

For more information click on this link-:https://www.impomedhealthcare.com

[impomed]

Gilteritinib 40 mg in India offers a breakthrough treatment for patients with acute myeloid leukemia (AML), particularly those with FLT3 mutations. This targeted therapy effectively inhibits cancer growth with fewer side effects compared to traditional treatments like chemotherapy. Reliable suppliers like Impomed Healthcare ensure easy access to Gilteritinib 40 mg in India, providing much-needed relief for patients. With ongoing research, Gilteritinib is poised to become an essential tool in the fight against aggressive cancer types across the country.

For more information click on this link-:https://www.impomedhealthcare.com

[impomed]

Blinatumomab 35 mcg Injection in India offers new hope for patients with relapsed or refractory B-cell precursor Acute Lymphoblastic Leukemia (ALL). This innovative immunotherapy targets cancer cells using the patient’s own immune system, significantly improving survival rates. Available across India through trusted providers like Impomed Healthcare, it is becoming an integral part of cancer treatment. Consult with your doctor to determine if Blinatumomab 35 mcg Injection in India is the right option for your specific needs.

For more information click on this link-:https://www.impomedhealthcare.com

[impomed]

Trastuzumab Deruxtecan 100 mg is a revolutionary targeted therapy used to treat HER2-positive breast cancer and other HER2-expressing malignancies. This antibody-drug conjugate improves survival rates by delivering chemotherapy directly to cancer cells, reducing damage to healthy tissue. Trastuzumab Deruxtecan 100 mg in India is gaining widespread availability, offering new hope to patients resistant to standard treatments. For reliable access to this life-saving therapy, Impomed Healthcare is a trusted supplier, ensuring timely and effective patient care.

For more information click on this link-:https://www.impomedhealthcare.com

[impomed]

Letermovir 480 mg Tablet in India has become a crucial antiviral treatment for preventing cytomegalovirus (CMV) reactivation in patients undergoing hematopoietic stem cell transplants. By significantly reducing the risk of CMV infection, Letermovir improves patient outcomes and lowers the chances of serious complications. With its convenient once-daily dosage and fewer side effects, Letermovir stands out as a safer long-term solution. Impomed Healthcare ensures easy access to Letermovir 480 mg Tablet in India, supporting better care for transplant patients.

For more information click on this link-:https://www.impomedhealthcare.com

[impomed]

Liposomal Irinotecan Injection is a breakthrough in cancer treatment, offering enhanced medicine delivery and fewer side effects. Liposomal Irinotecan Injection in India is primarily used for advanced pancreatic cancer and is also effective when combined with therapies like Vyxeos for treating Acute Myeloid Leukemia (AML). With healthcare providers like Impomed Healthcare making these treatments accessible, patients benefit from advanced therapies that improve outcomes and provide a more tolerable approach to cancer care.

For more information click on this link-:https://www.impomedhealthcare.com

[impomed]

Selpercatinib capsules have emerged as a breakthrough in targeted therapy for advanced cancers, offering hope to patients with RET-driven tumors, including non-small cell lung and thyroid cancers. This innovative treatment specifically targets cancer cells with RET gene mutations, reducing tumor growth and improving patient outcomes. Available as Selpercatinib 40 & 80 mg in India, it provides flexible dosing options for patients undergoing treatment. With its precision in targeting cancer cells, Selpercatinib is revolutionizing the way advanced cancers are treated, with Impomed Healthcare offering a more personalized approach to care. For more information Visit:- https://www.impomedhealthcare.com/

[impomed]

Sacituzumab Govitecan 180 mg is a cutting-edge treatment for metastatic triple-negative breast cancer now available in India. This targeted therapy Sacituzumab Govitecan 180 mg in India delivers chemotherapy directly to cancer cells, reducing side effects and improving survival rates. With providers like Impomed Healthcare, more patients have access to this advanced cancer treatment, offering new hope and a better quality of life.Access it through trusted providers like Impomed Healthcare.

For more information click on this link-:https://www.impomedhealthcare.com

[impomed]

Elotuzumab 300/400 mg in India offers a revolutionary treatment option for patients with relapsed or refractory multiple myeloma, a challenging blood cancer. By targeting the SLAMF7 protein, Elotuzumab enhances the immune system's ability to destroy cancerous plasma cells. Clinical trials show significant improvements in progression-free survival when combined with other therapies. Elotuzumab 300/400 mg in India is available through specialized oncology centers, with Impomed Healthcare striving to improve accessibility and affordability for patients across the country.

For more information click on this link-:https://www.impomedhealthcare.com