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why bother caring about the environment when 1. It’s so obviously a lost cause and 2. There’s definitely going to be a nuclear war?

And what are you doing about it Anon? Learn about ecological restoration or get out of my way.

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with love. you have to fact check shit. yes you. you still have to fact check shit. a lot of people are great at fact checking stuff they don’t want to be true, but somehow are still absolute ass at fact checking stuff that’s rhetorically convenient to them. even people my age, who I KNOW grew up doing internet/bibliography literacy workshops, and being warned not to believe anything that isn’t reliably sourced, people who DO harp on fact checking conservative output or whatever, are still kneejerk sharing unsourced shit that is partially or wholly untrue or misleading, because it suits whatever narrative they’re pursuing in that moment, without even a “take this with a grain of salt”. fact check!!!!!! look at the sources!!!!! yes it’s a drag!!! do it!!!!!

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"A cure for HIV could be a step closer after researchers found a new way to force the virus out of hiding inside human cells.

The virus’s ability to conceal itself inside certain white blood cells has been one of the main challenges for scientists looking for a cure. It means there is a reservoir of the HIV in the body, capable of reactivation, that neither the immune system nor drugs can tackle.

Now researchers from the Peter Doherty Institute for Infection and Immunity in Melbourne, have demonstrated a way to make the virus visible, paving the way to fully clear it from the body.

It is based on mRNA technology, which came to prominence during the Covid-19 pandemic when it was used in vaccines made by Moderna and Pfizer/BioNTech.

In a paper published in Nature Communications, the researchers have shown for the first time that mRNA can be delivered into the cells where HIV is hiding, by encasing it in a tiny, specially formulated fat bubble. The mRNA then instructs the cells to reveal the virus.

Globally, there are almost 40 million people living with HIV, who must take medication for the rest of their lives in order to suppress the virus and ensure they do not develop symptoms or transmit it. For many it remains deadly, with UNAids figures suggesting one person died of HIV every minute in 2023.

It was “previously thought impossible” to deliver mRNA to the type of white blood cell that is home to HIV, said Dr Paula Cevaal, research fellow at the Doherty Institute and co-first author of the study, because those cells did not take up the fat bubbles, or lipid nanoparticles (LNPs), used to carry it.

The team have developed a new type of LNP that those cells will accept, known as LNP X. She said: “Our hope is that this new nanoparticle design could be a new pathway to an HIV cure.”

When a colleague first presented test results at the lab’s weekly meeting, Cevaal said, they seemed too good to be true.

“We sent her back into the lab to repeat it, and she came back the next week with results that were equally good. So we had to believe it. And of course, since then, we’ve repeated it many, many, many more times.

“We were overwhelmed by how [much of a] night and day difference it was – from not working before, and then all of a sudden it was working. And all of us were just sitting gasping like, ‘wow’.”

Further research will be needed to determine whether revealing the virus is enough to allow the body’s immune system to deal with it, or whether the technology will need to be combined with other therapies to eliminate HIV from the body.

The study is laboratory based and was carried out in cells donated by HIV patients. The path to using the technology as part of a cure for patients is long, and would require successful tests in animals followed by safety trials in humans, likely to take years, before efficacy trials could even begin.

“In the field of biomedicine, many things eventually don’t make it into the clinic – that is the unfortunate truth; I don’t want to paint a prettier picture than what is the reality,” stressed Cevaal. “But in terms of specifically the field of HIV cure, we have never seen anything close to as good as what we are seeing, in terms of how well we are able to reveal this virus.

“So from that point of view, we’re very hopeful that we are also able to see this type of response in an animal, and that we could eventually do this in humans.”

Dr Michael Roche of the University of Melbourne and co-senior author of the research, said the discovery could have broader implications beyond HIV, with the relevant white blood cells also involved in other diseases including cancers.

Dr Jonathan Stoye, a retrovirologist and emeritus scientist at the Francis Crick Institute, who was not involved in the study, said the approach taken by the Melbourne team appeared be a major advance on existing strategies to force the virus out of hiding, but further studies would be needed to determine how best to kill it after that.

He added: “Ultimately, one big unknown remains. Do you need to eliminate the entire reservoir for success or just the major part? If just 10% of the latent reservoir survives will that be sufficient to seed new infection? Only time will tell.

“However, that does not detract from the significance of the current study, which represents a major potential advance in delivery of mRNA for therapeutic purposes to blood cells.”"

-via The Guardian, June 5, 2025

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Too many people will pass around "always trust your gut!" and "your intuition never lies" content when actually your "intuition" isn't immune to either propaganda, bigotry or trauma reactions. Which is important to be aware of actually

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Fruits Basket | Furuba – Chapter 80

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The Twin peaks; Funny Walk With Me :-) (2002)

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rothko in the turner gallery???

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"these researchers published a paper on something that literally any of us could have told you 🙄" ok well my supervisors wont let me write something in my thesis unless I can back it up with a citation so maybe it's a good thing that they're amplifying your voice to the scientific community in a way that prevents people from writing off your experiences as annecdotal evidence

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Eraserhead baby patch

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hi. fuck ice. here is how you can help families affected by unlawful deportation

edit: and FUCK LAPD. here is how you can help bail out protestors who are in the trenches, facing mass arrests and putting their bodies on the line.

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3rd & Spring | Downtown Los Angeles | 1937

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Reminder:

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I figured you gays like knives you you'll love this

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June 9, 2025 - A vendor selling hotdogs on the freeway in Los Angeles during the anti-ICE protests. [video]

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St. John's Bridge Portland, Oregon

Canon EOS 33 EF 50mm f/1.8 STM Kodak Ektar