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Blue Chromstar Affinity Chromatography Resins

Blue Chromstar FF/HP is an affinity chromatography medium made by covalently linking Cibacron Blue to a highly cross-linked agarose matrix by a triazine coupling method. The blue dye Cibacron Blue can bind to various proteins, such as albumin, lipoprotein, interferon, coagulation factors; it can also bind to various enzymes, such as kinases, dehydrogenases and most enzymes that require adenosine-containing cofactors (such as NAD+). Blue Chromstar HP is mainly used in the separation and purification of albumin, interferon, various nucleotide-dependent enzymes, α2-macroglobulin, coagulation factors and related proteins. Blue Chromstar HP has a finer particle size than Blue Chromstar FF, providing higher resolution.

Specifications of Blue Chromstar Affinity Chromatography Resins

Product

Feature

Mean particle size

Max. flow velocity

Quantity

Product code

(μ m)

(cm/h)

Blue Chromstar FF

High flow velocity

90

300

25 mL

1030-1131

For separation of

100 mL

1030-1132

antithrombin,

500 mL

1030-1133

lipoprotein,

1 L

1030-1134

interferon,

5 L

1030-1135

and albumin

10 L

1030-1136

20 L

1030-1137

Blue Chromstar HP

High resolution

34

200

25 mL

1030-1111

For separation of

100 mL

1030-1112

antithrombin,

500 mL

1030-1113

lipoprotein,

1 L

1030-1114

interferon,

5 L

1030-1115

and albumin

10 L

1030-1116

20 L

1030-1117

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Bioprocess Supporting Vessels

Tubing connections and components are an integral part of a Single-use bioprocess solution. Bio-Link provides customers with solutions for multiple disposable components including straight-through, variable diameter, tee, cross, Y-type, T-type, blind plate, clamp, chuck joint, etc. The material can be PP and PVDF to support the use requirements of different customers in different process steps. Besides that, Bio-Link can provide customized integrated assembly services to meet various application requirements such as flexible filter assembly, pipeline connection, tank connection, and liquid packaging. The Bio-Link disposable component product series has the following characteristics:

Conforms to ISO 9001 and ISO 13485 quality standards;

Excellent mold injection molding process, can be customized with various specifications and flexible choices;

Endurance to different use conditions: can Moist heat sterilization and radiation sterilization; 4. Complete verification documents.

Types of PVDF Single-use Bioprocess Accessories

3D Round Plastic Lab Support Bucket

Round plastic support barrels are designed for small volume buffers, intermediates. This product can be matched with liquid storage bags of different specifications to achieve safe storage of solution...

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3D Square Plastic Lab Folding Bucket

Square plastic folding buckets are designed for storage and transport of small to medium volume media, buffers and intermediate solutions. When in use, it can be folded and stacked, which can effectiv...

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3D Stainless Steel Lab Support Barrel

This product is mainly used for the storage and transfer of intermediate products. It can realize the temperature control of the material liquid, online weighing control, etc., and realize the safe st...

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2D Plastic Lab Tray

Plastic trays are used to support the BioHub® 2D Reservoir Bags for safe handling and transfer of various pharmaceutical process solutions.

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2D Cryoprotective Lab Case

The BioHub® 2D Cryoprotective case is combined with a flexible storage bag to design an integrated protective case. The strong stainless steel shell and high-density EVA foam ensure effective protect...

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2D Stainless Steel Lab Tray

Stainless steel trays are used to support the BioHub® 2D reservoir bags for safe handling and transfer of various pharmaceutical process solutions.

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Features of Single-use Bioprocess Accessories

BioHub® single-use components are specially developed and produced for the biopharmaceutical industry, supporting the needs of different customers in different steps, flexible and convenient. Bio-Link's single-use component product line has the following advantages:

Industry-leading independent mold opening and injection molding capabilities, can customize a variety of specifications, flexible choice

According to the principle of QbD, optimize the product structure design. The inner surface of the pipeline is smooth and free of burrs and shedding, the design of the large hook mouth is better in airtightness, and the internal structure transitions smoothly, reducing the formation of turbulent flow and helping the filling accuracy

Comply with ISO 9001 and ISO 13485 production standards to ensure process repeatability and robustness

Rinse and dry with purified water, the cleanliness is more guaranteed

The verification documents are complete, including but not limited to: no animal-derived components, USP <87> cytotoxicity test, USP <788> insoluble particle test, etc.

FAQs of Single-use Bioprocess Accessories

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What materials are disposable components made of?

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Bio-Link's disposable component products are made from a variety of materials including PP and PVDF. We have complete verification documents, including but not limited to: no animal-derived components, USP <87> cytotoxicity test, USP <788> insoluble particle test, etc. The product comply with ISO 9001 and ISO 13485 production standards to ensure process repeatability and robustness.

FAQ

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What is the sterilization method of PVDF disposable component products?

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Bio-Link's single-use component products have all undergone strict sterilization processes: 125°C autoclave sterilization 30min for 10 cycles. Besides that, the products are insed and dried with purified water to guarantee the cleanliness.

FAQ

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To what extent can Bio-Link provide component customization?

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Bio-Link provides customers with customized products, including customized development of single-use component products and ReadyLinX tubing assemble. If you have other special customization requirements for pipelines, please feel free to contact our sales representatives.

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Bioprocess Filtration Fixture

Bioprocess Filtration Fixture equipment is an essential component in biopharmaceutical and biotechnology industries for efficient filtration processes. This specialized equipment is designed to securely hold and support filtration components, such as filter cartridges or membranes, during bioprocess filtration. The fixture ensures a leak-free connection between the filtration media and the processing system, maintaining the integrity of the filtration process. It provides a stable platform for the filtration components, preventing any movement or misalignment that could compromise the filtration efficiency. Bioprocess Filtration Fixture equipment is designed with materials compatible with biological fluids and often incorporates features such as pressure monitoring to ensure optimal filtration performance and reliable results.

Types of Bioprocess Filtration Fixture

PC3 Depth Filtration Bioprocess Fixture

The depth filtration system is made to get rid of big cell particles when making biological products, including clarifying cells in bioreactor rooms or filtering intermediate products in purification rooms. The system's major components are an automatic control unit, a detection unit, a cassette holder, and a power unit.

PC3 Depth Filtration Bioprocess Fixture

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Depth Filtration Bioprocess Fixture Type M

In the processing of biological products, such as cell clarification (in bioreactor rooms) or intermediate product filtration (in purification rooms), the depth filtration system is intended to remove big cell particles. A power unit, a cassette holder, a detecting unit, and an automatic control unit make up the majority of the system.

FAQs of Bioprocess Filtration Fixture

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What are the benefits of using Bioprocess Filtration Fixture equipment?

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Bioprocess Filtration Fixture equipment offers several benefits, such as maintaining proper alignment of filtration media, ensuring leak-free connections, optimizing filtration efficiency, and enhancing the overall performance and reliability of bioprocessing filtration systems. It also allows for easy handling and replacement of filtration components.

FAQ

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Can Bioprocess Filtration Fixture equipment be sterilized?

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Yes, many Bioprocess Filtration Fixture equipment options are designed to be sterilizable. This is important in bioprocessing, where sterile filtration is required. Sterilization methods may include autoclaving, chemical sterilization, or other appropriate techniques to maintain aseptic conditions.

FAQ

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What is the purpose of Bioprocess Filtration Fixture equipment in bioprocessing?

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Bioprocess Filtration Fixture equipment is designed to securely hold and support filtration components, ensuring proper connections and maintaining filtration performance during bioprocessing. It provides stability and prevents movement or misalignment of filtration media, enhancing filtration efficiency.

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BioHub® Welder Aseptic Connector

The BioHub® Welder is an automated aseptic tubing system that offers a flexible, rapid, and cost-effective solution for aseptic fluid connections. This product enables the aseptic connection of disposable process bags, tubing components, and fittings in the biopharmaceutical manufacturing process without the need for pre-assembly in a non-sterile environment.

BioHub® Welder Aseptic Connector Application

Aseptic connection of TPE tubing for media storage bags

Aseptic connection of TPE tubing for feed bags

Aseptic connection of TPE tubing for other process steps

Features of BioHub® Welder Aseptic Connector

Automated Recognition: The fully automated tubing system can automatically identify the tubing specifications through the tube holder.

Easy Operation: Accurate and error-free tubing connection can be achieved by following step-by-step prompts on the touchscreen interface. Each step can be easily tracked and monitored.

Wide Compatibility: Compatible with tubing sizes ranging from OD1/4" to 1", enabling easy connections with both empty and liquid-filled tubes.

High Flexibility: Comes with standard C-Flex® 374 and AdvantaFlex® tubing brands, and supports customization with other tubing brands as well.

Efficiency: Rapid and reliable connections can be made within 180 seconds, saving valuable production time.

Bidirectional Tubing: Unique patented rotational technology allows for the creation of two independent tubing connections in a single operation, enhancing equipment versatility.

Enhanced User Experience: The tubing operation length is shortened to as little as 400mm, greatly improving user experience.

Data Reliability: The system ensures complete data integrity with comprehensive features such as three-level permissions, audit tracking, and data export capabilities.

Stability and Safety: Welding parameters and tubing connections undergo rigorous testing and validation to ensure continuous, stable, and robust aseptic connections.

Specifications of BioHub® Welder Aseptic Connector

Power Requirements

220V/50Hz

Power Consumption:

160W

Device Dimensions:

590mm*251mm*297mm

Net Weight:

19.4kg

Welding Time:

≤ 3min

Sealing Environment:

5~ 40° C，50%~80%RH

Protection Level

IP20

Ordering Information

Product Name

No.

Aseptic Tube Connector

BLKWELDER01

1/8*1/4 Tubing Holder（2 pcs/BX）

BLKTBHL01

1/4*3/8 Tubing Holder（2 pcs/BX）

BLKTBHL02

1/4*7/16 Tubing Holder（2 pcs/BX）

BLKTBHL03

3/8*5/8 Tubing Holder（2 pcs/BX）

BLKTBHL04

5/8*7/8 Tubing Holder（2 pcs/BX）

BLKTBHL05

1/2*3/4 Tubing Holder（2 pcs/BX）

BLKTBHL06

3/4*1 Tubing Holder（2 pcs/BX）

BLKTBHL07

IOQ Validation Service

IOQ-WELD-01

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Biohub SP Single-use Sterile Sampling Bags

BioHub® SP single-use sampling bags are designed for product sampling in cell culture and other processing. This product is an irradiated clean product, which can be used aseptically, thereby reducing the risk of residual contamination and ensuring the process.

Features of Biohub Sp Single-use Sterile Sampling Bags

Sampling bag volumes ranging from 50 mL to 1L

2mm needle, covering the sampling requirements of different types of liquids in the entire biopharmaceutical process

The material-liquid contact layer of the sampling bag is ULDPE, which meets the requirements of biopharmaceuticals

High transparency and good compatibility

The needle and the pipeline are integrally injection molded to ensure excellent airtightness and aseptic safety

Verification documents are sufficient to ensure safe use

The bag can be used at -80℃ to 60℃

Withstand pressure: 0.5bar for single needle single bag product, 0.3bar for single needle 5 bag product

Customized service available

The Use of Biohub Sp Single-use Sterile Sampling Bags

In the biopharmaceutical process, whether it is cell culture, separation and purification or final product filling, process sampling is a necessary and very critical important step. Samples collected through the BioHub® SP series are used to determine key purity attributes such as sterility, endotoxin levels, bioburden, and important parameters such as metabolites, nutrient levels, pH, and osmolarity during cultivation. The BioHub® Disposable Needle Prick Sampling Bag is a pre-assembled single-use sampling solution.

Specifications of Biohub Sp Single-use Sterile Sampling Bags

Product Code

Pack Size

Capacity

Inlet Pipeline

Outlet Pipeline

BS-X050-S001

50/box

50 mL

2 mm needle, silicone tube,

Silicone tube,

BS-X100-S001

100 mL

3.2 mm (ID) × 6.4 mm (OD),

3.2 mm (ID) × 6.4 mm (OD),

BS-X250-S001

250 mL

25 cm in length, with a metal

25 cm in length, with a

BS-X500-S001

500 mL

ring for sterile disconnection

needle-less sampling valve

BS-0001-S001

1000 mL

BS-X050-S002

5/box

2 × 50 mL

2 mm needle, silicone tube,

Silicone tube,

3.2 mm (ID) × 6.4 mm (OD),

3.2 mm (ID) × 6.4 mm (OD),

BS-X100-S002

2 × 100 mL

25 cm in length, with a metal

25 cm in length, with a

BS-X250-S002

2 × 250 mL

ring for sterile disconnection

needle-less sampling valve

BS-X050-S003

5/box

3 × 50 mL

2 mm needle, silicone tube,

Silicone tube,

3.2 mm (ID) × 6.4 mm (OD),

3.2 mm (ID) × 6.4 mm (OD),

BS-X100-S003

3 × 100 mL

25 cm in length, with a metal

25 cm in length, with a

BS-X250-S003

3 × 250 mL

ring for sterile disconnection

needle-less sampling valve

BS-X050-S004

5/box

5 × 50 mL

2 mm needle, silicone tube,

Silicone tube,

3.2 mm (ID) × 6.4 mm (OD),

3.2 mm (ID) × 6.4 mm (OD),

BS-X100-S004

5 × 100 mL

25 cm in length, with a metal

25 cm in length, with a

BS-X250-S004

5 × 250 mL

ring for sterile disconnection

needle-less sampling valve

Product

Description

Pack Size

PLUG001

Silicone plug with handle

100 pcs/pk

PLUG2MM001

Silicone plug

100 pcs/pk

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Biohub SP Single-use Laboratory Sample Bottles

BioHub® SP single-use sampling bottles are designed for product sampling in cell culture and other processing. It can be used for sensitive liquids, buffers, media, etc. This product is a clean product after irradiation, which can be used aseptically, thereby reducing the risk of residual contamination and ensuring process safety.

Features of Biohub Sp Single-use Laboratory Sample Bottles

Sampling bottle volumes range from 20 mL to 250 mL

2mm needle, covering the sampling requirements of different types of liquids in the entire biopharmaceutical process

The sampling bottle is made of PC, which meets the requirements of biopharmaceuticals

High transparency and good compatibility

The needle and the pipeline are integrally injection molded to ensure excellent airtightness and aseptic safety

Verification documents are sufficient to ensure safe use;

The sampling bottle can be used at -80℃ to 121℃

Withstand pressure: 0.5bar for single needle single bag product, 0.3bar for single needle 5 bag product

Customized service available

Specifications of Biohub Sp Single-use Laboratory Sample Bottles

Sampling bottle

Product Code

Pack Size

Capacity

Inlet Pipeline

Outlet Pipeline

TSTG-ST037

50/box

20 mL

2 mm needle, silicone tube,

Silicone tube,

TSTG-ST038

40/box

50 mL

3.2 mm (ID) × 6.4 mm (OD),

3.2 mm (ID) × 6.4 mm (OD),

TSTG-ST039

25/box

125 mL

25 cm in length, with a metal

25 cm in length, with a venting filter

TSTG-ST040

20/box

250 mL

ring for sterile disconnection

TSTG-ST041

10/box

2 × 20 mL

2 mm needle, silicone tube,

Silicone tube,

TSTG-ST042

5/box

2 × 50 mL

3.2 mm (ID) × 6.4 mm (OD),

3.2 mm (ID) × 6.4 mm (OD),

TSTG-ST043

4/box

2 × 125 mL

25 cm in length, with a metal

25 cm in length, with a venting filter

TSTG-ST044

3/box

2 × 250 mL

ring for sterile disconnection

TSTG-ST045

10/box

3 × 20 mL

TSTG-ST046

5/box

3 × 50 mL

2 mm needle, silicone tube,

Silicone tube,

3.2 mm (ID) × 6.4 mm (OD),

3.2 mm (ID) × 6.4 mm (OD),

TSTG-ST047

4/box

3 × 125 mL

25 cm in length, with a metal

25 cm in length, with a venting filter

TSTG-ST048

3/box

3 × 250 mL

ring for sterile disconnection

TSTG-ST049

10/box

5 × 20 mL

2 mm needle, silicone tube,

Silicone tube,

3.2 mm (ID) × 6.4 mm (OD),

3.2 mm (ID) × 6.4 mm (OD),

TSTG-ST050

5/box

5 × 50 mL

25 cm in length, with a metal

25 cm in length, with a venting filter

TSTG-ST051

4/box

5 × 125 mL

ring for sterile disconnection

TSTG-ST052

3/box

5 × 250 mL

TSTG-ST053

NA

2 mm needle, silicone tube, 3.2 mm (ID) × 6.4 mm (OD), 50cm in length,

with a metal ring for sterile disconnection and a male Luer connector

and cap at the end

TSTG-ST054

50/box

NA

2 mm needle, C-Flex tube, 3.2 mm (ID) × 6.4 mm (OD), 50 cm in length,

with a male Luer connector and cap at the end

TSTG-ST055

NA

2 mm needle, PVC tube, 3.2 mm (ID) × 6.4 mm (OD), 50 cm in length,

with a male Luer connector and cap at the end

Plug

Product

Description

Pack Size

PLUG001

Silicone plug with handle

100 pcs/pk

PLUG2MM001

Silicone plug

100 pcs/pk

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BioHub Single-use Mixing System

Through the magnetic coupling mechanism, the motor drives the single-use stirring blades in the stirring bag to rotate, which can meet various needs such as liquid-liquid mixing, solid-liquid mixing, etc.

Please be advised that this product is only available for sale and after-sales support in certain regions. For further details, kindly consult with your local sales representative. Thank you for your understanding.

Features of BioHub Single-use Mixing System

Volume range: 50L~2500L

The whole machine adopts 304 stainless steel polishing design; Ra≤0.8μm, no damage to the soft bag body

The square design is conducive to the baffle effect of the material liquid to enhance the mixing efficiency

The bottom is inclined to reduce the residue of liquid

Modular design, pH, cond, temperature, weighing, peristaltic pump, printer, etc. can be selected according to needs

Advantages of BioHub Single-use Mixing System

The BioHub® Series Single-use Mixing System works through a magnetic coupling motor to drive the single-use stirring paddles in the mixing bag to rotate, and is equipped with physical shaft seals. This system is safe, reliable, stable and efficient. Working together with a stainless steel bin, it can meet various liquid-liquid mixing and solid-liquid mixing needs, suitable for medium preparation, buffer preparation, intermediate mixing, semi-finished product preparation, and final pharmaceutical products mixing.

The mixing system consists of a stainless steel bin, a control system, a magnetic mixing motor, and a  single-use mixer bag. The modular design allows for flexible combinations of different functions on demand, such as mixing, weighing, feedback-controlled temperature monitoring, pH, and conductivity, while supporting high levels of customization to the complex needs of customers. The system also provides three-level permissions and electronic signature to meet the data integrity needs of pharmaceutical customers.