fsmbuddy121 - Tumblr blog

fsmbuddy121 · 3 years

Text

buy 2-oxo-pcm

BUY 2-Oxo-PCM buy 2-oxo-pcm . 2′-Oxo-PCE (also known as as Eticyclidone, and O-PCE) is a lesser-known novel dissociative substance of the arylcyclohexylamine class that produces dissociative, anesthetic, stimulating and hallucinogenic effects when administered. It is structurally related to arylcyclohexylamines like MXE, 3-MeO-PCE, and deschloroketamine and is speculated to produce its effects through its activity as an NMDA receptor antagonist.

The structural similarities O-PCE shares with DCK and ketamine which has been speculated to have antibacterial properties,[1][2] has raised some concern as to whether it also shares these properties as well. However, due to the lack of scientific research on the subject, whether this is true currently remains entirely unknown. It is advised that users of this substance should keep in mind that the possibility of prolonged use may pose a serious threat to one’s health and immune system if this does prove to be the case.

O-PCE is an example of a contemporary designer drug specifically chosen to mimic and/or replace the functional and structural features of its predecessors. It has recently become commonly available through online research chemical vendors[3] where it is being marketed and sold as a designer drug replacement for MXE and other dissociatives for recreational purposes. Unlike many other research chemical dissociatives, there is almost a total absence of scientific literature on O-PCE, particularly with regards to its toxicity, addiction and abuse potential in humans.

Due to its novelty and extremely short history of human usage, all information related to the use of this compound should be treated with extreme caution. Users should also avoid frequent redosing as it is reported to be relatively easy to overdose due to its potency and stimulating nature. It is strongly recommended that one use harm reduction practices if choosing to use this substance.

Chemistry Of 2-oxo-pcm (buy 2-oxo-pcm) O-PCE, or 2′-Oxo-PCE, belongs to the arylcyclohexylamine chemical class. Arylcyclohexylamine drugs are named for their structures which include a cyclohexane ring bound to an aromatic ring along with an amine group. Deschloroketamine contains a phenyl ring bonded to a cyclohexane ring substituted with an oxo group (cyclohexanone) at R1. Bound to the adjacent alpha carbon (R2) of the cyclohexanone ring is an amino ethyl chain -NCH2CH3. 2′-Oxo-PCE, like MXE contains an amino ethyl chain rather than the amino methyl chain found in DCK and ketamine. 2′-Oxo-PCE is homologous to DCK, differing only in the length of their carbon chain.

Pharmacology to know before you buy 2-oxo-pcm Further information: NMDA receptor antagonist Due to the lack of research regarding the substance, all discussion regarding the pharmacology of it is purely based on its structure and subjective effect similarities to other arylcyclohexylamine dissociatives such as ketamine, PCE and methoxetamine (3-MeO-2′-Oxo-PCE). While no scientific studies have been conducted to verify this, structure-activity relationship analysis suggests that 2′-Oxo-PCE likely exhibits its observed effects principally as an NMDA receptor antagonist, although other neurotransmitter systems may be involved.[citation needed]

NMDA receptors (a subtype of receptors for glutamate, which are the principle excitatory neurotransmitters in the nervous system) allow for electrical signals to pass between nerve cells in the brain and spinal column; for the signals to pass, the receptor must be open. NMDA receptor antagonists have been shown to disrupt this signaling by blocking these receptors. This disconnection of information flow in the nervous system leads to loss of sensation (anesthesia), difficulty moving (motor discoordination), and eventually this substance’s equivalent of the “K-hole.”[citation needed]

Subjective effects to know before you buy 2-oxo-pcm In comparison to DCK, ketamine and MXE, this compound can be described as generally more stimulating with fewer cognitive and sensory suppressions. The first half of its duration has been reported to produce primarily stimulating effects with minimal dissociation whilst the second half is primarily dissociating with minimal stimulation.

Users have compared the nature and cognitive effects to MXE specifically, albeit without the pronounced “body warmth” or physical euphoria and a having a tendency of producing rather stimulating and chaotic responses with higher dosages.

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), a research literature based on anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be regarded with a healthy degree of skepticism. It is worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become much more likely with higher doses and may include addiction, serious injury, or death. .

Toxicity and harm potential in regards when you buy 2-oxo-pcm Further information: Research chemicals § Toxicity and harm potential The toxicity and long-term health effects of recreational O-PCE use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because O-PCE has very little history of human usage. Anecdotal evidence from people who have tried O-PCE within the community suggests that there do not seem to be any negative health effects attributed to simply trying this substance at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed).

O-PCE shares a close structural relationship to deschloroketamine (O-PCM) and ketamine (2-Cl-O-PCM), which has been speculated to have immuno-modulative properties.[1][4] It is not known whether O-PCE also has these properties due to the lack of sufficient scientific research. However, the possibility should be kept in mind because prolonged use could potentially pose a serious threat to one’s health and immune system.

It is strongly recommended that one use harm reduction practices, such as volumetric dosing, when using this substance to ensure the accurate administration of the intended dose.

Tolerance and addiction potential As with other NMDA receptor antagonists, the chronic use of O-PCE can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage.

Tolerance to many of the effects of O-PCE develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 – 7 days for the tolerance to be reduced to half and 1 – 2 weeks to be back at baseline (in the absence of further consumption). O-PCE presents cross-tolerance with all dissociatives, meaning that after the consumption of O-PCE all dissociatives will have a reduced effect.

Urinary tract effects of buy 2-oxo-pcm In terms of its long-term health effects when used repeatedly and excessively for extended periods of time, O-PCE seems to exhibit similar bladder and urinary tract problems to those found within ketamine, although to what extent is unclear. This is likely because O-PCE is significantly more potent than ketamine, meaning that less of the drug needs to be consumed. Symptoms of ketamine-induced cystitis can become extremely serious and can be described as:

Urinary frequency – Urinary frequency is the need to empty the bladder every few minutes. Urinary urgency – This can be described as a sudden, compelling need to urinate. Urinary pressure – This is experienced as a constant sensation of fullness in the bladder that is unrelieved by urination. Pelvic and bladder pain – Pain can develop suddenly and severely, particularly as the bladder fills with urine. Hematuria – Hematuria is visible blood in the urine. Incontinence – This is the leakage of urine. However, anecdotal evidence suggests that these symptoms can be largely avoided by refraining from using O-PCE on a regular basis (e.g. weekly at the bare minimum) and carefully monitoring and limiting one’s intake of the substance.

Dangerous interactions Although many psychoactive substances are reasonably safe to use on their own, they can suddenly become dangerous or even life-threatening when combined with other substances. The following list includes some known dangerous combinations (although it is not guaranteed to include all of them). Independent research (e.g. Google, DuckDuckGo) should always be conducted to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

Stimulants – Both stimulants and dissociatives carry the risk of adverse psychological reactions like anxiety, mania, delusions and psychosis and these risks are exacerbated when the two substances are combined. Depressants – Because both depress the respiratory system, this combination can result in an increased risk of suddenly falling unconscious, vomiting and choking to death from the resulting suffocation. If nausea or vomiting occurs, users should attempt to fall asleep in the recovery position or have a friend move them into it.

Legality

Germany: 2-Oxo-PCE is not a controlled substance under the BtMG.[5] It is legal, as long as it is not sold for human consumption, according to §2 AMG.[6] Switzerland: O-PCE is a controlled substance specifically named under Verzeichnis E.[7] United Kingdom – 2-Oxo-PCE is a class B drug in the UK and is illegal to possess, produce, supply, or import. As an N-alkyl derivative of 2-Amino-2-phenylcyclohexanone, it is covered by the arylcyclohexylamine generic clause added to the Misuse of Drugs Act by S.I. 2013/239, which came into effect on the 26th February 2013

0 notes

fsmbuddy121 · 3 years

Text

Iboga Powder/Pure Iboga Powder for sale

Iboga Powder/Pure Iboga Powder for sale Iboga Powder/Pure Iboga Powder for sale is a naturally occurring psychoactive substance found in plants in the family Apocynaceae such as Tabernanthe iboga, Voacanga africana, and Tabernaemontana undulata. It is a psychedelic with dissociative properties.

Preliminary research indicates that it may help counter drug addiction. Its use has been associated with serious side effects and death. Between the years 1990 and 2008, a total of 19 fatalities temporally associated with the ingestion of ibogaine were reported, from which six subjects died of acute heart failure or cardiopulmonary arrest. The total number of subjects who have used it without major side effects during this period remains unknown. It is used as an alternative medicine treatment for drug addiction in some countries. Its prohibition in other countries has slowed scientific research.[4] Ibogaine is also used to facilitate psychological introspection and spiritual exploration. Derivatives of ibogaine that lack the substance’s psychedelic properties (such as 18-MC) are under clinical trials, have been shown to be neither psychedelic nor psychoactive, and have a positive safety profile in humans. Iboga Powder/Pure Iboga Powder for sale

The psychoactivity of the root barks of the iboga tree (Tabernanthe iboga), from which ibogaine is extracted, was first discovered by the Pygmy tribes of Central Africa, who passed the knowledge to the Bwiti tribe of Gabon. French explorers in turn learned of it from the Bwiti tribe and brought iboga back to Europe in 1899–1900, where it was subsequently marketed in France as Lambarene. Ibogaine-containing preparations are used for medicinal and ritual purposes within African spiritual traditions of the Bwiti, who claim to have learned it from the Pygmy peoples. Although it was first commonly advertised as having anti-addictive properties in 1962 by Howard Lotsof, its Western use predates that by at least a century. In France, it was marketed as Lambarène and used as a stimulant. Also, the U.S. Central Intelligence Agency (CIA) studied the effects of ibogaine in the 1950s.. Iboga Powder/Pure Iboga Powder for sale

Iboga Powder/Pure Iboga Powder for sale is an indole alkaloid that is obtained either by extraction from the iboga plant or by semi-synthesis from the precursor compound voacangine, another plant alkaloid. The total synthesis of ibogaine was described in 1956.[11] Structural elucidation by X-ray crystallography was completed in 1960.

Psychoactive effects of Iboga Powder/Pure Iboga Powder for sale Ibogaine is derived from the root of the Tabernanthe iboga, a plant known to exhibit psychedelic effects in its users. The experience of ibogaine occurs in two phases, termed the visionary phase and the introspection phase. The visionary phase has been described as oneirogenic, referring to the dreamlike nature of its psychedelic effects, and lasts for 4 to 6 hours. The second phase, the introspection phase, is responsible for the psychotherapeutic effects. It can allow people to conquer their fears and negative emotions. Ibogaine catalyzes an altered state of consciousness reminiscent of dreaming while fully conscious and aware so that memories, life experiences, and issues of trauma can be processed .

Medical Uses Of Iboga Powder/Pure Iboga Powder for sale See also: Ibogaine § Research Ibogaine is not currently approved for any medical uses. There are legal ibogaine rehabilitation facilities in Mexico. Clinical studies of ibogaine to treat drug addiction began in the early 1990s, but concerns about cardiotoxicity led to termination of those studies. There is currently insufficient data to determine whether it is useful in treating addiction. Nonetheless, some alternative medicine clinics administer ibogaine for this purpose, in what has been called a “vast, uncontrolled experiment.” As of May 2020, there is a phase-2 clinical trial of ibogaine for the treatment of alcoholism scheduled for August 2020 in Brazil.

Religious In Bwiti religious ceremonies, the root bark is pulverized and swallowed in large amounts to produce intense psychoactive effects. Iboga Powder/Pure Iboga Powder for sale

Adverse effects of Iboga Powder/Pure Iboga Powder for sale Immediate One of the first noticeable effects of large-dose ibogaine ingestion is ataxia, a difficulty in coordinating muscle motion which makes standing and walking difficult without assistance. Xerostomia (dry mouth), nausea, and vomiting may follow. These symptoms may be long in duration, ranging from 4 to 24 hours in some cases. Ibogaine is sometimes administered per rectum to avoid nausea and vomiting. Ibogaine decreases body temperature.

Cardiovascular Ibogaine causes long QT syndrome at higher doses, apparently by blocking hERG potassium channels in the heart.]

Neurotoxicity Work in the laboratory of Mark Molliver at Johns Hopkins indicated degeneration of cerebellar Purkinje cells observed in rats given substantially larger dosages of ibogaine than those used to study drug self-administration and withdrawal. However, subsequent research found no evidence of neurotoxicity in a primate or mouse at dosages that produced cerebellar degeneration in the rat, and it has been suggested that cerebellar degeneration might be a phenomenon limited to a single species. The FDA was aware of Molliver’s work at the time it approved a phase-1 study in which humans received ibogaine in 1993. Neuropathological examination revealed no evidence of degenerative changes in a woman who had received four separate doses of ibogaine ranging between 10 and 30 mg⁄ kg over a 15-month interval. A published series of fatalities temporally associated with the ingestion of ibogaine found no evidence suggesting a characteristic syndrome of neurotoxicity. Iboga Powder/Pure Iboga Powder for sale

Addiction treatment The most-studied therapeutic effect of ibogaine is the reduction or elimination of addiction to opioids. An integral effect is the alleviation of symptoms of opioid withdrawal. Research also suggests that ibogaine may be useful in treating dependence on other substances such as alcohol, methamphetamine, and nicotine, and may affect compulsive behavioral patterns not involving substance abuse or chemical dependence. Researchers note that there remains a “need for systematic investigation in a conventional clinical research setting.” Iboga Powder/Pure Iboga Powder for sale

Many users of ibogaine report experiencing visual phenomena during a waking dream state, such as instructive replays of life events that led to their addiction, while others report therapeutic shamanic visions that help them conquer the fears and negative emotions that might drive their addiction. It is proposed that intensive counseling, therapy, and aftercare during the interruption period following treatment is of significant value. Some individuals require a second or third treatment session with ibogaine over the course of 12 to 18 months. A minority of individuals relapse completely into opiate addiction within days or weeks. A comprehensive article (Lots of 1995) on the subject of ibogaine therapy detailing the procedure, effects, and aftereffects is found in “Ibogaine in the Treatment of Chemical Dependence Disorders: Clinical Perspectives”. Ibogaine has also been reported in multiple small-study cohorts to reduce cravings for methamphetamine. Iboga Powder/Pure Iboga Powder for sale

There is also evidence that this type of treatment works with LSD, which has been shown to have a therapeutic effect on alcoholism. Both ibogaine and LSD appear to be effective for encouraging introspection and giving the user occasion to reflect on the sources of their addiction, while also producing an intense, transformative experience that can put established patterns of behavior into perspective; ibogaine has the added benefit of preventing withdrawal effects.

Chronic pain management In 1957, Jurg Schneider, a pharmacologist at CIBA (now a division of Novartis), found that ibogaine potentiated morphine analgesia. No additional data was ever published by CIBA researchers on ibogaine–opioid interactions. Almost 50 years later, Patrick Kroupa and Hattie Wells released the first treatment protocol for concomitant administration of ibogaine with opioids in human subjects, indicating that ibogaine reduced tolerance to opioid drugs. Their paper in the Multidisciplinary Association for Psychedelic Studies journal demonstrated that administration of low “maintenance” doses of ibogaine HCl with opioids decreases tolerance, but noted that ibogaine’s potentiating action could make this a risky procedure.

Psychotherapy Ibogaine has been used as an adjunct to psychotherapy by Claudio Naranjo, documented in his book The Healing Journey. He was awarded patent CA 939266 in 1974. Iboga Powder/Pure Iboga Powder for sale

0 notes

fsmbuddy121 · 3 years

Text

Buy jwh-210 online

buy jwh-210 online buy jwh-210 online .JWH-210 is an analgesic chemical from the naphthoylindole family, which acts as a potent cannabinoid agonist at both the CB1 and CB2 receptors, with Ki values of 0.46 nM at CB1 and 0.69 nM at CB2. It is one of the most potent 4-substituted naphthoyl derivatives in the naphthoylindole series, having a higher binding affinity (i.e. lower Ki) at CB1 than both its 4-methyl and 4-n-propyl homologues JWH-122 (CB1 Ki 0.69 nM) and JWH-182 (CB1 Ki 0.65 nM) respectively, and than the 4-methoxy compound JWH-081 (CB1 Ki 1.2 nM).[2] It was discovered by and named after John W. Huffman.

TO buy jwh-210 online may be neurotoxic to animals when administered in high doses

buy jwh-210 online Legal status In the United States, all CB1 receptor agonists of the 3-(1-naphthoyl)indole class such as JWH-210 are Schedule I Controlled Substances.

JWH-210 and JWH-122 were banned in Sweden on 1 October 2010 as hazardous goods harmful to health, after being identified as ingredients in “herbal” synthetic cannabis products.[5][6] The substances JWH-210, JWH-122 and JWH-203 were classified as illegal drugs by the Swedish government as of 1 September 2011.

As of October 2015 JWH-210 is a controlled substance in China

0 notes

fsmbuddy121 · 3 years

Text

5-methyl-ethylone med for sale

5-methyl-ethylone med for sale Effects and research 5-methyl-ethylone med for sale Drug discrimination studies showed that 5-methyl-MDA substitutes for MDA, MMAI, and LSD, but not amphetamine, suggesting that it produces a mix of entactogen and hallucinogenic effects without any stimulant effects.[citation needed]

5-Methyl-MDA acts as a selective serotonin releasing agent (SSRA) with IC50 values of 107nM, 11,600nM, and 1,494nM for serotonin, dopamine, and norepinephrine efflux.[1] It is over 5 times more potent than MDA in vitro assays, with a suitable active dose possibly in vivo being around 15–25 mg.[1] Subsequent testing in vivo, however, has found that it is not as potent as once thought and is active at at least 100 mg. 2-Methyl-MDA is also much more potent than MDA, but is not quite as potent as 5-methyl-MDA.[1] 6-methyl-MDMA (also known as Madam-6) is mostly inactive, likely due to steric hindrance.

Recent research has used data on 2-methyl-MDA and 5-methyl-MDA to help guide computer modeling of the serotonin transporter complex.[3]

Legal status to buy Buy 5-Methyl-Ethylone for sale 5-Methyl-MDA is not scheduled by the United Nations ‘ Convention on Psychotropic Substances.

United States

5-Methyl-MDA is not scheduled at the federal level in the United States , but it is possible that 5-Methyl-MDA could legally be considered an analog of MDA, in which case, sales or possession could potentially be prosecuted under the Federal Analogue Act.[6]

0 notes

fsmbuddy121 · 3 years

Text

2-nmc / Buy 2-nmc powder

2-nmc / Buy 2-nmc powder is a Cathinone research chemical with a CAS number of 8378231-23-02.

The chemical formula for 2-NMC Crystals is C12H17NO and the IUPAC Name is N-Methyl-N-p-tolyl-isobutyramide. The molecular mass is a 191.00.2-nmc wiki,2 nmc drug,2nmc

2-nmc / Buy 2-nmc powder is a new research chemical. Due to this, there is no information available other than what is mentioned above until more time is devoted to learning more about the chemical.

Since 2-nmc / Buy 2-nmc powder is however listed as, a Cathinone which is close to the same as ephedrine, methcathinone, and other amphetamines. We can assume that 2-NMC Crystals will work closely as other cathinone, which are found to encourage dopamine release while inhibiting the re-uptake of norepinephrine, epinephrine, and serotonin in the brain as well as the central nervous system.2-A1MP

Cathinone is known as a hydrophobic molecule, which means that it can cross other membranes in order to interact with the monoamine transporters.2-nmc wiki,2 nmc drug,2nmc

2-nmc / Buy 2-nmc powder is NOT intended for animal or human consumption and is only intended for research purposes in a controlled laboratory for scientific and forensic study.

view our research chemical store for all your needs, order high purity from Us and save 10% with coupon code. We ship all our high purity research chemicals from Ukraine, Poland, Canada, United States, and the EU depending on the customer’s location, where all products are dispatched. 2-ME-MAF

Our highly developed distribution network guarantees that all products you receive will be on time and will be sent to the most convenient locations for pickup, and delivered to your scheduled destination, we are prompt and reliable.

Customers satisfaction is our ultimate goal, and we are here to serve our customers, make decisions to buy all research chemical products from trusted Research chemicals online store you are guaranteed prompt supply of all your orders to your given address. 4-CEC . 2-nmc / Buy 2-nmc powder

We also provide various shipping services that deliver products to our clients in various markets and in many different locations around the globe. 2-nmc wiki,2 nmc drug,2nmc

All products found on this website are sold for the sole purpose of research and education. None of our products is sold for human or animal consumption or for any type of illegal usage.

View, browse our research chemical online store for all your needs, buy, order high purity products and save 10% of the market prices with a coupon code. 2-A1MP

1 note · View note

fsmbuddy121 · 3 years

Text

44-DMAR/buy 44-dmar online

44-DMAR/buy 44-dmar online . 4,4′-Dimethylaminorex (abbreviated as 4,4′-DMAR), sometimes referred to by the street name “Serotoni”, is a psychostimulant and entactogen designer drug related to aminorex, 4-methylaminorex, and pemoline.[2] It was first detected in the Netherlands in December 2012, and has been sold as a designer drug around Europe since mid-2013.

44-DMAR/buy 44-dmar online had been linked to at least 31 deaths in Hungary, Poland, and the UK by February 2014, mostly when consumed in combination with other drugs.[4] Nineteen deaths linked to 4,4′-DMAR were reported in Northern Ireland in the same time period.

44-DMAR/buy 44-dmar online acts as a potent and balanced serotonin-norepinephrine-dopamine releasing agent (SNDRA), with EC50 values for serotonin, norepinephrine, and dopamine release of 18.5 nM, 26.9 nM, and 8.6 nM, respectively.

Chemical and physical characteristics

4,4′-DMAR, IUPAC name 4-methyl-5-(4-methylphenyl)-4,5-dihydrooxazol-2-amine, is a synthetic substituted oxazoline derivative classified as an analogue of both aminorex and 4-methylaminorex (fig. 1) 10. Aminorex is listed in Schedule I, and 44-DMAR/buy 44-dmar online is listed in Schedule IV of the 1971 United Nations Convention on Psychotropic Substances 10. Chemical differences among these stimulants are related to the presence of methyl groups. Aminorex has no methyl groups, while 4-methylaminorex has a 4-position methyl group located on the oxazoline ring 11. 4,4′-DMAR contains an additional methyl group in para-position on the phenyl ring 11. 4,4′-DMAR, molecular formula C11H14N2O, has two chiral centres within the oxazoline ring leading to four enantiomers 11. Cis- and trans-free base racemates prepared from the same 4′-methyl-norephedrine precursor performed with cyanogen bromide or cyanate to synthesize both products have been described as colourless solids 12. Cis- and trans-free base forms show a melting point of 136–138°C and 101–103°C, respectively, while the water-soluble cis-4,4′-DMAR hydrochloride form shows a melting point of 163–165°C 12. The cis-44-DMAR/buy 44-dmar online hydrochloride salt is a white crystalline powder available as research chemical in online research chemical stores 12.

Pharmacology

No study has investigated the effects of 4,4′-DMAR in human beings, and no pharmacokinetic studies are available. Recently, a pharmacodynamic study performed in male Sprague–Dawley rat synaptosomes has investigated the monoamine release induced by (+/−)-cis-4,4′-DMAR comparing the activity of these racemates with that of d-amphetamine, aminorex and (+/−)-cis-4-methylaminorex 12. The study showed that (+/−)-cis-44-DMAR/buy 44-dmar online, d-amphetamine, aminorex and (+/−)-cis-4-methylaminorex were potent dopamine, noradrenaline and serotonin releasers (table 1). Dose–response curve highlighted that (+/−)-cis-4,4′-DMAR elicited a potent releasing activity at dopamine (DAT), noradrenaline (NET) and serotonin transporters (SERT) with a EC50 of 8.6 (+/−) 1.1 nM, 26.9 (+/−) 5.9 nM and 18.5 (+/−) 2.8 nM, respectively (table 1). The study also demonstrated that the DAT/SERT ratio for (+/−)-cis-4,4′-DMAR, d-amphetamine, aminorex and (+/−)-cis-4-methylaminorex was 2, 473, 45 and 31, respectively 12. In another recent study performed in rat brain synaptosomes, monoamine release activity of both cis-4,4′-DMAR and trans-4,4′-DMAR isomers was compared to that of (S)-(+)-3,4-methylenedioxymethamphetamine (MDMA) 13. The study showed that cis-4,4′-DMAR and trans-4,4′-DMAR isomers exerted a dopamine- and noradrenaline-releasing activity more potent than that of MDMA (table 1). Regarding the activity at SERT, cis-4,4′-DMAR showed to be a fully efficacious releasing agent, while trans-4,4′-DMAR acted as a fully efficacious uptake blocker (table 1) 13. The study has also highlighted that the DAT/SERT ratio for (S)-(+)-MDMA, cis-4,4′-DMAR and trans-4,4′-DMAR was 0.6, 1.6 and 2.5, respectively

Toxicology

No pre-clinical or clinical study has evaluated the toxicological effects of 4,4′-DMAR in human beings. Since October 2013, 44-DMAR/buy 44-dmar onlinehas been analytically confirmed in biological samples of thirty-one deaths and one severe intoxication reported to the EMCDDA via the early warning system 11. Poland signalled a non-fatal intoxication which occurred in September 2013 and that involved a 16-year-old female admitted to the hospital after legal high consumption. She felt ill, collapsed and vomited after smoking an unknown herbal mixture. In a blood sample collected 24 hr after admission 4,4′-DMAR was found at a concentration of 0.448 mg/L 11. Regarding the thirty-one deaths (table 2), twenty-two were reported in the United Kingdom between June 2013 and June 2014, eight in Hungary between June and October 2013 and one in Poland in July 2013 11. Except for a case in the United Kingdom, sex and age data were collected for all deceased people. They were twenty-two males and eight females with a middle age of 27.93 years. In twenty-seven cases, 4,4′-DMAR was quantified in blood samples, and in three of them, it was also quantified in urine samples. In one case, 44-DMAR/buy 44-dmar online was the only detected substance, while in all the other cases, additional drugs were found, including cocaine, amphetamines, cannabis, benzodiazepines, antidepressants, second-generation antipsychotics, opioids and synthetic cathinones. Clinical examination demonstrated high body temperature, pupil dilation, muscular spasm, seizure, increased perspiration, cardiac and respiratory arrest, agitation, confusion, unconsciousness and paranoia. Autopsy revealed bleeding in muscles and organs, brain and pulmonary oedema, right atrial and ventricular dilation

Medical use

To the best of our knowledge, there is no approved medical indication for the 4,4′-DMAR, and it must be considered a drug for research and forensic utilization 11, 12. The (4S,5S)-trans-4,4′-DMAR enantiomer has been used in some patients related to the preparation of anti-inflammatory medicines based on phospholipase A2 inhibitors 15.

0 notes

fsmbuddy121 · 3 years

Text

Buy 2-FDCK online

Get More information Before you Buy 2-FDCK online Buy 2-FDCK online,2-Fl-2′-Oxo-PCM (also known as 2-Fluorodeschloroketamine, 2-FDCK, and inaccurately as 2-Fluroketamine, Fluoroketamine, and 2-FK) is a lesser-known novel dissociative substance of the arylcyclohexylamine class that produces dissociative, anesthetic, and hallucinogenic effects when administered. It is structurally related to arylcyclohexylamines like ketamine and deschloroketamine and is reported to produce similar effects.

Buy 2-FDCK online , Like other dissociative substances, it is primarily sought by recreational users for its ability to induce a hallucinogenic “out of body” state referred to as “dissociative anesthesia” (although the extent to which this occurs is highly dose-dependent). It has recently become available through online research chemical vendors where it is being sold as a designer drug replacement for ketamine.

There is very little information on the pharmacology, metabolism or toxicity of 2-fluorodeschloroketamine. It has an extremely brief history of human use. It is strongly advised to use harm reduction practices if using this substance.

Buy 2-FDCK online – Chemistry

2-Fluorodeschloroketamine, or 2-(2-Fluorophenyl)-2-methylamino-cyclohexanone, is classed as an arylcyclohexylamine drug. Arylcyclohexylamines drugs are named for their structures which include a cyclohexane ring bound to an aromatic ring along with an amine group. 2-FDCK contains a phenyl ring bonded to a cyclohexane ring substituted with a ketone group (cyclohexanone). An amino methyl chain (-N-CH3) is bound to the adjacent alpha carbon (R2) of the cyclohexanone ring. Additionally, the phenyl ring is substituted at R2 with a fluorine group.

2-Fluorodescholoroketamine is a chiral molecule and is often produced as a racemate. Des- is a prefix used in chemistry to denote the absence of a functional group (in this case “chloro”) hence 2-FDCK is named for containing a fluorine substitution at its phenyl ring rather than the chlorine which is found in ketamine.

Toxicity

The toxicity and long-term health effects of recreational 2-FDCK use do not seem to have been studied in any scientific context, therefore the exact toxic dosage is unknown. Furthermore, 2-FDCK has very little history of human usage. Anecdotal evidence from people who have tried 2-FDCK within the community suggests there aren’t any negative health effects attributed by simply trying this drug at low to moderate doses and using it sparingly (but nothing can be completely guaranteed).

Due to this, it is strongly recommended that one use harm reduction practices when using this drug.

Buy 2-FDCK online – Abuse

As with other NMDA receptor antagonists, the chronic use of 2-Fluorodeschloroketamine can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage.

Tolerance to many of the effects of 2-FDCK develops with prolonged and repeated use. This results in increasingly large doses to achieve the same effects. Moreover, it takes about 3 – 7 days for the tolerance to be reduced to half, and 1 – 2 weeks to be back at baseline (in the absence of further consumption). 2-Fluorodeschloroketamine presents cross-tolerance with all dissociatives, meaning that after the consumption of 2-Fluorodeschloroketamine all dissociatives will have a reduced effect.

Urinary tract effects

In terms of its long-term health effects when used repeatedly and with excess for extended periods of time, 2-Fluorodeschloroketamine seems to exhibit almost identical bladder and urinary tract problems to those found within ketamine but to a lesser extent. This is because 2-Fluorodeschloroketamine is a little more potent than ketamine, meaning that less of the drug needs to be consumed. ketamine-induced cystitis symptoms can become extremely serious and can be described as:

However, all of these, can easily be avoided by simply not using 2-Fluorodeschloroketamine on a daily, and even weekly basis and manually limiting one’s usage of the substance.

0 notes

fsmbuddy121 · 3 years

Text

25I-NBOMe 25B-NBOMe 25C-NBOMe

25I-NBOMe 25B-NBOMe 25C-NBOMe Analysis Abstract 25I-NBOMe, 25B-NBOMe, 25C-NBOMe . In recent years, N-methoxybenzyl-methoxyphenylethylamine (NBOMe) derivatives, a class of designer hallucinogenic drugs, have become popular drugs of abuse. These drugs have been the cause of severe intoxications and even deaths. They act as 5-HT2A receptors agonists and have been reported to produce serotonin-like syndrome with bizarre behavior, severe agitation and seizures persisting for as long as 3 days. The most commonly reported derivatives are 25I-NBOMe, 25B-NBOMe and 25C-NBOMe, respectively 2-(4-iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl) methyl]ethanamine, N-(2-methoxybenzyl)-2,5-dimethoxy-4-bromophenethylamine and N-(2-methoxybenzyl)-2,5-dimethoxy-4-chlorophenethylamine. Like many low dose hallucinogenic drugs these compounds are often sold on blotter paper. Three different types of commercially available blotter papers reported to contain NBOMe derivatives were obtained. These blotter papers were screened using Direct Analysis in Real Time AccuTOFTM mass spectrometry followed by confirmation and quantification by high-performance liquid chromatography triple quadrapole mass spectrometry. The major drug present on each of the three blotter products was different, 25I-NBOMe, 25C-NBOMe or 25B-NBOMe. The blotter papers were also found to have minute amounts of two or three NBOMe derivative impurities of 25H-NBOMe, 25I-NBOMe, 25C-NBOMe, 25B-NBOMe and/or 25D-NBOMe.

Introduction

Recently, a new class of “2C” serotonin 5-HT2A receptor agonists designer drugs, dimethoxyphenyl-N-[(2-methoxyphenyl) methyl]ethanamine (NBOMe) derivatives have become easily obtainable over the Internet which has resulted in their abuse in the USA, Europe and Asia (1). Stimulation of 5-HT2A receptors is responsible for the hallucinogenic effects of recreational drugs such as lysergic acid diethylamide (LSD) and 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (2). The terminology “2C” is an acronym coined by Alexander Shulgin for the two carbon atoms between the benzene ring and the amino group on the perceptional distorting and/or hallucinogenic phenylethylamine derivatives he synthesized (3, 4). Several of these derivatives, including 2-(4-iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl) methyl]ethanamine (25I-NBOMe) and N-(2-methoxybenzyl)-2,5-dimethoxy-4-bromophenethylamine (25B-NBOMe) were first synthesized by Ralf Heim at the Free University of Berlin as part of a series of pharmacological tools to study the 5-HT2A receptor (5–7). Blotter papers containing 25I-NBOMe appeared on the designer drug market beginning in 2011 (8) and since then numerous NBOMe derivatives have been identified in blotter papers seized from the illicit drug market including: 2-(2,5-dimethoxy-4-methylphenyl)-N-(2-methoxybenzyl)ethanamine (25D-NBOMe), 2-(4-ethyl-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine (25E-NBOMe), 2-(2,5-dimethoxy-3,4 dimethylphenyl)-N-(2-methoxybenzyl)ethanamine (25G-NBOMe), N-(2-methoxybenzyl)-2,5-dimethoxy-4-chlorophenethylamine (25C-NBOMe) and 2-(4-iodo-2,5-dimethoxyphenyl)-N-[(2,3-methylenedioxyphenyl) methyl]ethanamine (25I-NBMD) (9–11).

Several published abstracts and clinical case reports have described signs and symptoms of 25I-NBOMe (1, 8, 12–16), 25B-NBOMe (17–20) and 25C-NBOMe (18–21) intoxication. These reports reveal NBOMe intoxicated patients are typically young males, 14–29 years old with clinical presentations of a serotonin-like syndrome with bizarre behavior and severe agitation and seizures persisting for as long as 3 days. 25I-NBOMe intoxication has been ruled the cause of death in two cases in which the drug was detected in blood and urine (22). Quantified distribution of 25I-NBOMe in body fluids and tissues from a case of traumatic death has also been reported (23). Deemed a hazard to public health and safety, the Drug Enforcement Administration placed 25I-NBOMe, 25B-NBOMe and 25C-NBOMe into Schedule 1 of the Controlled Substances Act on 10 October 2013 (24).

Currently, the most widely abused of the many NBOMe derivatives appears to be 25I-NBOMe (25–28) which is sold as a powder or on blotter paper under the names 25I-NBOMe, “N-Bomb” and “Smiles”. Anecdotal reports indicate the powder in doses of 50–250 µg may be administered sublingually, by insufflation or applied to the buccal cavity. 25I-NBOMe blotter papers usually contain higher doses of 500–800 µg, apparently due to low bioavailability of the drug. Psychoactive drugs of abuse with very high potency having effective doses in the microgram (µg) range are often dissolved in a volatile solution and dropped or soaked on to blotter paper. The paper is often perforated into tiny squares or “tabs” which can be torn or cut apart and placed under the tongue or swallowed. Historically, LSD has been distributed on blotter paper with colorful and/or unique artwork which may serve as a trademark in the illicit drug trade. NBOMe blotter paper is similarly marked with identifying artwork and is often distributed and/or sold on the street as “blotter acid”, in reference to LSD.

We present the analysis of three different types of commercial available blotter papers reported to contain NBOMe derivatives. The blotter papers were ordered over the Internet and received before 25I-NBOMe, 25C-NBOMe or 25B-NBOMe were categorized as Schedule I according to the Federal Controlled Substances Act in November 2013. The blotters were advertised as containing 500 µg of either 25I-NBOMe, 25C-NBOMe or 25B-NBOMe. The approximate price per “hit” of blotter paper was $5 USD.

These blotter papers arrived via the mail with a customs declaration form attached to the front of the package claiming to contain a “music CD”. Upon opening the package, a Christmas music CD case was found that contained three different small bags containing blotter paper (Figure 1). The first type of blotter paper pictured part of a psychedelic sun and was labeled “25C-NBOMe”; the second type of blotter paper pictured part of a pyramid with an eye and was labeled “25I-NBOMe”; and the third type of blotter paper pictured Felix the Cat and was labeled “25B-NBOMe”. These blotter papers were screened using Direct Analysis in Real Time AccuTOFTM mass spectrometry (DART-MS) followed by confirmation and quantification by high-performance liquid chromatography triple quadrapole mass spectrometry (HPLC–MS-MS). The DART-MS method for the rapid detection of NBOMe derivatives was performed on both the blotter paper and the blotter papers dissolved in methanol. Ten other NBOMe derivatives including: (E)-2-(4-iodo-2,5-dimethoxyphenyl)-N-(2-methoxybenzylidene)ethanamine (25I-NBOMe imine), 25I-NBOMD, N-(2-fluorobenzyl)-2-(4-iodo-2,5-dimethoxyphenyl)ethanamine (25I-NBF), 25G-NBOMe, 25D-NBOMe, 2-(2,5-dimethoxyphenyl)-N-(2-methoxybenzylidene) ethanamine (25H-NBOMe), (E)-2-(2,5-dimethoxyphenyl)-N-(2-methoxybenzylidene)ethanamine (25H-NBOMe imine), 25B-NBOMe, 25C-NBOMe and 2-(2,5-dimethoxy-4-(methylthio)phenyl)-N-(2-methoxybenzyl)ethanamine (2CT-NBOMe) were also evaluated in methanol. Confirmation and quantification were performed on the methanol dissolved blotter papers using HPLC–MS-MS.

Methods Reagents The primary reference materials for 25I-NBOMe, 25I-NBOMe imine, 25I-NBMD, 25I-NBF, 25G-NBOMe, 25D-NBOMe, 25H-NBOMe, 25H-NBOMe imine, 25B-NBOMe, 25C-NBOMe and 2CT-NBOMe were purchased from Cayman Chemical Company (Ann Arbor, MI, USA) as hydrochloride salts. Polyethylene glycol (PEG) was purchased from ULTRA Inc. (North Kingstown, RI, USA). Melting point tubes were obtained from Corning Incorporated (Corning, NY, USA). Certified ACS ammonium acetate, formic acid, HPLC grade methanol and deionized (DI) water were purchased from Fisher Scientific (Hanover Park, IL, USA). Medical grade nitrogen and helium were purchased from National Welders Supply Company (Richmond, VA, USA). Blotter papers containing NBOMe derivative were obtained through the Internet at future-labs.eu.

Sample and reagent preparation NBOMe derivative standards were individually prepared at 10, 25, 50 and 100 µg/mL. A 10 µg/mL NBOMe derivative mix standard containing: 25I-NBOMe, 25I-NBOMe imine, 25I-NBMD, 25I-NBF, 25G-NBOMe, 25D-NBOMe, 25H-NBOMe, 25H-NBOMe imine, 25B-NBOMe and 25C-NBOMe was also prepared. A set of the three different blotter paper products were each added to 10 mL of methanol which was then gently mixed to extract the NBOMe derivatives. All stock standards were stored at −20°C until testing.

DART-MS analysis For 25I-NBOMe 25B-NBOMe 25C-NBOMe The screening was performed using a DART-MS operated in positive-ion mode and controlled by Mass Center software version 1.3.4m (JEOL Inc. Tokyo, Japan). The Direct Analysis in Real Time ion source had the helium gas flow rate at 2.0 L/min, gas heater temperature of 300°C, discharge electrode needle at 4,000 V, Electrode 1 was set at 150 V and Electrode 2 at 250 V. The resolving power of the mass spectrometer was 6,000 full width at half maximum. Measurements were taken with the ion guide peak voltage of 800 V, reflectron voltage of 900 V, Orifice 1 was operated at 300°C in 20, 60 or 90 V using switching mode that created a single file for all three voltages, Orifice 2 was set at 5 V and the ring lens was set at 3 V. The measured mass range was from 40 to 1,100 Da.

25I-NBOMe 25B-NBOMe 25C-NBOMe .Sampling for the DART-MS was performed as previously described by Steiner et al. (29). In brief, a mass spectrum of PEG with average molecular weight 600 was obtained with each data acquisition set as a reference standard to enable exact mass measurements. The PEG and methanol standards containing the NBOMe derivatives were measured by dipping the closed end of a cleaned glass melting point tube into the standard. The blotter papers were analyzed by DART-MS using two different sampling methods. The first analysis Of 25I-NBOMe 25B-NBOMe 25C-NBOMedid not involve any sample preparation. The blotter paper was held with a pair of forceps and placed directly into the DART-MS gas stream. The second analysis was performed by adding each blotter paper to 10 mL of methanol and gently mixing for 1 h. The methanol solutions were then sampled by dipping the closed end of a clean glass melting point tube into the methanol containing the blotter paper. The standards and samples were then moved back in forth, or wanded, in to the DART gas stream. Each of the samples or standards was wanded two times. The signal with the greatest abundance was used for the data analysis. Data were created using an averaged, background subtracted, centroided spectrum that was calibrated to the PEG + H mass reference table. The measured [M+H]+ spectra were compared with theoretical masses of each drug or fragment produced by in-source collision-induced dissociation. 25I-NBOMe 25B-NBOMe 25C-NBOMe

The evaluation of the 25I-NBOMe 25B-NBOMe 25C-NBOMe derivatives in methanol was conducted over five separate days. The NBOMe derivative standards were analyzed for limit of detection (LOD), precision and selectivity. The LOD of the DART-MS was evaluated using the 10, 25, 50 and 100 µg/mL of each NBOMe derivative standard. They were analyzed ten times using different aliquots. The intra- and interday precision for the mass accuracy was calculated from the analysis of five aliquots of each 25I-NBOMe 25B-NBOMe 25C-NBOMe derivative standard on three separate days for a total of 15 replicates. The selectivity of the DART-MS was determined for the NBOMe derivatives using the 10 µg/mL of 25I-NBOMe 25B-NBOMe 25C-NBOMe derivative mix standard. The acceptance criteria for each NBOMe derivative to be considered above LOD were met if the measured mass was within the instrument manufacturer’s specification of ± 5.0 mmu of the theoretical mass. Selectivity was determined if the individual NBOMe derivatives could be distinguished in with the mixture.

HPLC–MS-MS analysis 25I-NBOMe 25B-NBOMe 25C-NBOMe The confirmation and quantification of the NBOMe derivatives on the blotter papers was performed using a modified previously published HPLC-MS-MS method (30). In brief, the instrument was an Applied Biosystems 3200 Q trap with a turbo V source for TurbolonSpray attached to a Shimadzu SCL HPLC system controlled by Analyst 1.4.2 software. Chromatographic separation was performed on a Restek Allure Biphenyl 5 µm 100 × 3.2 mm column (Bellefonte, PA, USA). The mobile phase consisted of A: DI Water with 10 mM ammonium acetate and 0.1% formic acid and B: methanol. The following gradient was used: 0.00–1.0 min starting at 50% B with a linear gradient to 80% B, then using linear gradient ending at 10.0 min to 70% B and finally returning at 10.1 min to 50% B. The source temperature was set at 650°C and had a curtain gas flow rate of 30 mL/min. The ionspray voltage was 5,000 V, with the ion source gases 1 and 2 at flow rates of 30 mL/min. The acquisition mode used was multiple reaction monitoring. The retention times (min), declustering potential (V), transition ions (m/z) and corresponding collection energies (eV) for all the compounds can be found in Table I. The total run time for the analytical method was 13 min. 25I-NBOMe 25B-NBOMe 25C-NBOMe

0 notes