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LEAPChem Has Fulvestrant (129453-61-8) Now!

If you are interested in Fulvestrant, look no further than LEAPChem - Pharmaceutical Chemicals. We are an ISO:9001 certified organization attesting to the highest quality management practices in the pharmaceutical chemicals industry. Our professional team of technical specialists, logistics, compliance and customer service experts will provide a safe, time efficient, and cost-effective process from manufacturer to delivery at the port or warehouse of your choice. LEAPChem Highlights Fulvestrant today!

 Basic Information of Fulvestrant

Chemical Name: Fulvestrant

Cas No.: 129453-61-8

Molecular Formula: C32H47F5O3S

Chemical Structure:

  Fulvestrant, sold under the brand name Faslodex among others, is a medication used to treat hormone receptor (HR)-positive metastatic breast cancer in postmenopausal women with disease progression as well as HR-positive, HER2-negative advanced breast cancer in combination with palbociclib in women with disease progression after endocrine therapy. It is given by injection into a muscle.

Fulvestrant is a selective estrogen receptor degrader (SERD) and was first-in-class to be approved. It works by binding to the estrogen receptor and destabilizing it, causing the cell's normal protein degradation processes to destroy it.

Fulvestrant is used for the treatment of hormone receptor positive metastatic breast cancer or locally advanced unresectable disease in postmenopausal women; it is given by injection. A 2017 Cochrane review found it is as safe and effective as first line or second line endocrine therapy.

It is also used to treat HR-positive, HER2-negative advanced or metastatic breast cancer in combination with palbociclib in women with disease progression after first-line endocrine therapy.

Hormones are chemical substances that are produced by glands in the body, which enter the bloodstream and cause effects in other tissues. For example, the hormone testosterone made in the testicles and is responsible for male characteristics such as deepening voice and increased body hair. The use of hormone therapy to treat cancer is based on the observation that receptors for specific hormones that are needed for cell growth are on the surface of some tumor cells. Hormone therapies work by stopping the production of a certain hormone, blocking hormone receptors, or substituting chemically similar agents for the active hormone, which cannot be used by the tumor cell.  The different types of hormone therapies are categorized by their function and/or the type of hormone that is affected.

Many breast cancers have estrogen receptors, and the growth of these tumors can be stimulated by estrogen. Fulvestrant is an estrogen receptor downregulator, this means it binds to the estrogen receptor site in competition with estrogen in the body.  Once it binds to the site it causes the receptors to break down, thereby preventing normal cellular response to estrogen.

Fulvestrant is a selective estrogen receptor degrader (SERD).

It works by binding to the estrogen receptor and making it more hydrophobic, which makes the receptor unstable and misfold, which in turn leads normal processes inside the cell to degrade it.

Fulvestrant is slowly absorbed and maximum plasma concentrations (Cmax) are reached after about 5 days and the terminal half-life is around 50 days. Fulvestrant is highly (99%) bound to plasma proteins including very low density lipoprotein, low density lipoprotein, and high density lipoprotein. It appears to be metabolized along the same pathways as endogenous steroids; CYP3A4 may be involved, but non-cytochrome routes appear to be more important. It does not inhibit any CYP450 enzymes. Elimination is almost all via feces.

 LEAPChem is committed to providing our customers with quality products and services. With a varied and vetted collective of suppliers, LEAPChem can provide products to meet any of your specifications and needs.

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 References:

https://en.wikipedia.org/wiki/Fulvestrant

https://www.ncbi.nlm.nih.gov/pubmed/20156170

https://www.ncbi.nlm.nih.gov/pubmed/16198056

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Lead acetate trihydrate (6080-56-4) is Available in LEAPChem Now!

Allow a company with a ISO 9001 certification to handle all your pharmaceutical chemical needs. From finding a reliable manufacturer who creates a quality product meeting your specifications, to shipping to the port or facility to your choice, LEAPChem - Pharmaceutical Chemicals experienced and professional staff will make the process as smooth as possible. LEAPChem Highlights Lead acetate trihydrate today!

 Basic Information of Lead acetate trihydrate

Chemical Name: Lead acetate trihydrate

Cas No.: 6080-56-4

Molecular Formula: Pb(C2H3O2)2

Chemical Structure:

  Lead(II) acetate (Pb(CH3COO)2), also known as lead acetate, lead diacetate, plumbous acetate, sugar of lead, lead sugar, salt of Saturn, or Goulard's powder, is a white crystalline chemical compound with a sweetish taste. It is made by treating lead(II) oxide with acetic acid. Like other lead compounds, it is toxic. Lead acetate is soluble in water and glycerin. With water it forms the trihydrate, Pb(CH3COO)2·3H2O, a colourless or white efflorescent monoclinic crystalline substance.

The substance is used as a reagent to make other lead compounds and as a fixative for some dyes. In low concentrations, it is the principal active ingredient in progressive types of hair colouring dyes. Lead(II) acetate is also used as a mordant in textile printing and dyeing, and as a drier in paints and varnishes. It was historically used as a sweetener and for cosmetics.

Like other lead(II) salts, lead(II) acetate has a sweet taste, which led to its historical use as a sugar substitute. The ancient Romans, who had few sweeteners besides honey, would boil must (grape juice) in lead pots to produce a reduced sugar syrup called defrutum, concentrated again into sapa. This syrup was used to sweeten wine and to sweeten and preserve fruit. It is possible that lead(II) acetate or other lead compounds leaching into the syrup might have caused lead poisoning in those who consumed it. Lead acetate is no longer used in the production of sweeteners because of its recognized toxicity. Modern chemistry can easily detect it, which has almost completely stopped the illegal use that continued decades after legal use as a sweetener was banned.

Lead(II) acetate paper is used to detect the poisonous gas hydrogen sulfide. The gas reacts with lead(II) acetate on the moistened test paper to form a grey precipitate of lead(II) sulfide.

An aqueous solution of lead(II) acetate is the byproduct of the 50/50 mixture of hydrogen peroxide and white vinegar used in the cleaning and maintenance of stainless steel firearm suppressors (silencers) and compensators. The solution is agitated by the bubbling action of the hydrogen peroxide, and the main reaction is the dissolution of lead deposits within the suppressor by the acetic acid, which forms lead acetate. Because of its high toxicity, this chemical solution must be appropriately disposed by a chemical processing facility or hazardous materials centre. Alternatively, the solution may be reacted with sulfuric acid to precipitate nearly insoluble lead(II) sulfate. The solid may then be removed by mechanical filtration and is safer to dispose of than aqueous lead acetate.

 As an experienced supplier of pharmaceutical chemicals for more than 10 years, LEAPChem is fully equipped to fill your pharmaceutical chemical requirements efficiently and exceed your expectations. Our customer service team is always ready to provide a personal touch to every conversation and ensure quick reply, professional support, and reliability at every step.

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 References:

https://en.wikipedia.org/wiki/Lead(II)_acetate

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1470238/

https://www.ncbi.nlm.nih.gov/pubmed/9114341

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Order 1-Naphthalene acetic acid (86-87-3) from LEAPChem Now!

Searching for niche products has always been a problem. You have to spend much valuable time looking for a supplier, and then you need to make sure the provider is reputable. Usually, successfully finding a reputable, reliable, and responsible supplier of high quality chemicals must be a headache. Relax now, because those days are over! By coming to the LEAPChem - Pharmaceutical Chemicals website, you have come one step closer to acquiring your trouble free pharmaceutical chemicals. LEAPChem Highlights 1-Naphthalene acetic acid today!

 Basic Information of 1-Naphthalene acetic acid

Chemical Name: 1-Naphthalene acetic acid

Cas No.: 86-87-3

Molecular Formula: C12H10O2

Chemical Structure:

  1-Naphthaleneacetic acid (NAA) is an organic compound with the formula C10H7CH2CO2H. This colorless solid is soluble in organic solvents. It features a carboxylmethyl group (CH2CO2H) linked to the "1-position" of naphthalene. NAA is a synthetic plant hormone in the auxin family and is an ingredient in many commercial plant rooting horticultural products; it is a rooting agent and used for the vegetative propagation of plants from stem and leaf cutting. It is also used for plant tissue culture.

The hormone NAA does not occur naturally, and, like all auxins, is toxic to plants at high concentrations. In the United States, under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), products containing NAA require registration with the Environmental Protection Agency (EPA) as pesticides.

NAA is widely used in agriculture for various purposes. It is considered to be only slightly toxic but when at higher concentrations it can be toxic to animals. This was shown when tested on rats via oral ingestion at 1000–5900 mg/kg. NAA has been shown to greatly increase cellulose fiber formation in plants when paired with another phytohormone called gibberellic acid. Because it is in the auxin family it has also been understood to prevent premature dropping and thinning of fruits from stems. It is applied after blossom fertilization. Increased amounts of it can actually have negative effects however, and cause growth inhibition to the development of plant crops. It has been used on many different crops including apples, olives, oranges, potatoes, and various other hanging fruits. In order for it to obtain its desired effects it must be applied in concentrations ranging from 20–100 µg/mL. NAA present in the environment undergoes oxidation reactions with hydroxyl radicals and sulphate radicals. Radical reactions of NAA was studied by using pulse radiolysis technique. Hydroxyl adduct radical was formed as the intermediate during the reaction of hydroxyl radical with NAA. The intermediate Naphtyl methyl radical was formed during the reaction of sulphate radical anion with NAA.

In micro propagation of various plants NAA is typically added to a media containing nutrients essential to the plants survival. It is added to help induce root formation in various plant types. It can also be applied by spraying it onto plants and which is typical in agricultural use. It is prohibited in many areas to use it in high concentrations due to the health concerns towards humans and other animals.

 At LEAPChem, we place emphasis on the importance of each step of the distribution process. From sourcing, to supply chain logistics, to customer service, and the technical know-how in between, LEAPChem is a trusted industry leader. We will be the strongest link in your supply chain and help you to get the products you need accurately, on time, and on budget.

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 References:

https://en.wikipedia.org/wiki/1-Naphthaleneacetic_acid

https://www.ncbi.nlm.nih.gov/pubmed/9697346

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC366374/

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LEAPChem Has Cefixime (79350-37-1) Now!

At LEAPChem - Pharmaceutical Chemicals, we proudly distribute the materials that are required for the wide range of our customers’ production processes. We understand that each production process is unique, which is why we provide custom services and chemical knowledge tailored to each customer specifically. With LEAPChem, you can look forward to receiving the operational benefits of working with an international company paired with the customer service and reliable follow up of a small business. LEAPChem Highlights Cefixime today!

 Basic Information of Cefixime

Chemical Name: Cefixime

Cas No.: 79350-37-1

Molecular Formula: C16H15N5O7S2

Chemical Structure:

  Cefixime is an antibiotic useful to treat a number of bacterial infections. This includes otitis media, strep throat, pneumonia, urinary tract infections, gonorrhea, and Lyme disease. For gonorrhea typically only one dose is required. In the United States it is a second line treatment to ceftriaxone for gonorrhea. It is taken by mouth.

Common side effects include diarrhea, abdominal pain, and nausea. Serious side effects may include allergic reactions and Clostridium difficile diarrhea. It is not recommended in people with a history of a severe penicillin allergy. It appears to be relatively safe during pregnancy. It is in the third generation cephalosporin class of medications. It works by disrupting the bacteria's cell wall resulting in its death.

Cefixime is a semi-synthetic (partially man-made), oral antibiotic in the cephalosporin family of antibiotics. The cephalosporin family includes cephalexin (Keflex), cefaclor (Ceclor), cefuroxime (Zinacef), cefpodoxime (Vantin), cefprozil (Cefzil), and many injectable forms. Like other cephalosporins, cefixime stops bacteria from multiplying by preventing bacteria from forming the walls that surround them. The walls are necessary to protect bacteria from their environment and to keep the contents of the bacterial cell together; most bacteria cannot survive without a cell wall. Cefixime is active against a very wide spectrum of bacteria such as Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes (the cause of strep throat), Hemophilus influenzae, Moraxella catarrhalis, E. coli, Klebsiella, Proteus mirabilis, Salmonella, Shigella, and Neisseria gonorrhoeae. The FDA approved cefixime in April 1989.

 As an industry leader in chemical sourcing, LEAPChem has strong relationships with vendors, suppliers, and customers worldwide that allow us to access hard to find chemicals at competitive prices. Our warehouses are equipped to handle kosher, organic, hazardous, and non-hazardous materials. We have established partnerships with import and export providers making seamless international shipping possible.

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 References:

https://en.wikipedia.org/wiki/Cefixime

https://www.ncbi.nlm.nih.gov/pubmed/9404906

https://www.ncbi.nlm.nih.gov/pubmed/2530548

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Source Sildenafil citrate (171599-83-0) from LEAPChem Now!

LEAPChem - Pharmaceutical Chemicals is a premier supplier of pharmaceutical chemicals and other chemical raw materials for global customers including drug manufacturers, universities, research labs, R&D centers, and other industries that use chemical raw materials such as polymers, textiles, agriculture, coatings, etc. As an ISO 9001:2015 certified company, our team of experts in customer service, product sourcing, logistics, regulatory and compliance operate at the highest standard. LEAPChem's experienced sales team will work tirelessly to find the chemicals you need for a price you can afford. LEAPChem Highlights Sildenafil citrate today!

 Basic Information of Sildenafil citrate

Chemical Name: Sildenafil citrate

Cas No.: 171599-83-0

Molecular Formula: C11H8O2

Chemical Structure:

  Sildenafil, sold as the brand name Viagra among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension.

Its effectiveness for treating sexual dysfunction in women has not been demonstrated.

Common side effects include headaches and heartburn, as well as flushed skin. Caution is advised in those who have cardiovascular disease. Rare but serious side effects include prolonged erections, which can lead to damage to the penis, and sudden-onset hearing loss. Sildenafil should not be taken by people who take nitrates such as nitroglycerin (glycerin trinitrate), as this may result in a severe and potentially fatal drop in blood pressure.

Sildenafil acts by inhibiting cGMP-specific phosphodiesterase type 5 (phosphodiesterase 5, PDE5), an enzyme that promotes degradation of cGMP, which regulates blood flow in the penis.

Pfizer scientists Andrew Bell, David Brown, and Nicholas Terrett originally discovered sildenafil as a treatment for various cardiovascular disorders. Since becoming available in 1998, sildenafil has been a common treatment for erectile dysfunction; its primary competitors are tadalafil (trade name Cialis) and vardenafil (Levitra).

The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse). Its use is now one of the standard treatments for erectile dysfunction, including for men with diabetes mellitus.

Tentative evidence suggests that sildenafil may help men who experience antidepressant-induced erectile dysfunction.

While sildenafil improves some markers of disease in people with pulmonary arterial hypertension, it does not appear to affect the risk of death or serious side effects as of 2014.

Sildenafil and other PDE5 inhibitors are used off-label to alleviate vasospasm and treat severe ischemia and ulcers in fingers and toes for people with secondary Raynaud's phenomenon; these drugs have moderate efficacy for reducing the frequency and duration of vasospastic episodes. As of 2016, their role more generally in Raynaud's was not clear.

Sildenafil protects cyclic guanosine monophosphate (cGMP) from degradation by cGMP-specific phosphodiesterase type 5 (PDE5) in the corpus cavernosum. Nitric oxide (NO) in the corpus cavernosum of the penis binds to guanylate cyclase receptors, which results in increased levels of cGMP, leading to smooth muscle relaxation (vasodilation) of the intimal cushions of the helicine arteries. This smooth muscle relaxation leads to vasodilation and increased inflow of blood into the spongy tissue of the penis, causing an erection. Robert F. Furchgott, Ferid Murad, and Louis Ignarro won the Nobel Prize in Physiology or Medicine in 1998 for their independent study of the metabolic pathway of nitric oxide in smooth muscle vasodilation.

 As a verified ISO:9001 certified organization, we at LEAPChem demonstrate a high level of care in the distribution of our vast catalog of raw materials—accurately, on time, and on budget—by way of our knowledgeable sales specialists, thorough customer service and compliance departments, and cost-effective logistics management.

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 References:

https://en.wikipedia.org/wiki/Sildenafil

https://www.ncbi.nlm.nih.gov/pubmed/11220982

https://www.ncbi.nlm.nih.gov/pubmed/10400408

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LEAPChem Supplies Menadione (58-27-5) Now!

Searching for niche products has always been a problem. You have to spend much valuable time looking for a supplier, and then you need to make sure the provider is reputable. Usually, successfully finding a reputable, reliable, and responsible supplier of high quality chemicals must be a headache. Relax now, because those days are over! By coming to the LEAPChem - Pharmaceutical Chemicals website, you have come one step closer to acquiring your trouble free pharmaceutical chemicals. LEAPChem Highlights Menadione today!

 Basic Information of Menadione

Chemical Name: Menadione

Cas No.: 58-27-5

Molecular Formula: C11H8O2

Chemical Structure:

  Menadione is an organic compound with the formula C6H4(CO)2C2H(CH3). It is an analog of 1,4-naphthoquinone with a methyl group in the 2-position.

It is occasionally used as a nutritional supplement in animal feed because of its vitamin K activity.

It is sometimes called vitamin K3, although derivatives of naphthoquinone are not naturally occurring chemicals and therefore do not qualify as vitamins, and without the side chain in the 2-position (which, as the methyl group is retained in vitamine K, in the structural formula of menadione is the unsubstituted 3-position!) they cannot exert all the functions of the K vitamins. Menadione is metabolized by the human body into K2 which uses alkylation to yield menaquinones (MK-n, n=1-13; K2 vitamers), hence is better classified as a provitamin. It is also known as "menaphthone".

It is an intermediate in the chemical synthesis of vitamin K by first reduction to the diol menadiol, which is suscepible to coupling to the phytol.

Despite the fact that it can serve as a precursor to various types of vitamin K, menadione is generally not used as a nutritional supplement in economically developed countries. Menadione for human use at pharmaceutical strength is available in some countries with large lower income populations. It is used in the treatment of hypoprothrombinemia outside of the United States.

Menadione in combination with vitamin C has been investigated for the treatment for prostate cancer.

It was reported, that menadione topical lotion reduces epidermal growth factor receptor inhibitor-related side effects by the prevention of skin toxicities that result from inhibition of protein kinases by drugs such as erlotinib (Tarceva) and cetuximab (Erbitux), however, the paper was later retracted.

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 References:

https://en.wikipedia.org/wiki/Menadione

https://www.ncbi.nlm.nih.gov/pubmed/8048083

https://www.ncbi.nlm.nih.gov/pubmed/15939799

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Order Estradiol (50-28-2) from LEAPChem Now!

Allow a company with a ISO 9001 certification to handle all your pharmaceutical chemical needs. From finding a reliable manufacturer who creates a quality product meeting your specifications, to shipping to the port or facility to your choice, LEAPChem - Pharmaceutical Chemicals’s experienced and professional staff will make the process as smooth as possible. LEAPChem Highlights Estradiol today!

 Basic Information of Estradiol

Chemical Name: Estradiol

Cas No.: 50-28-2

Molecular Formula: C18H24O2

Chemical Structure:

  Estradiol (E2), also spelled oestradiol, is an estrogen steroid hormone and the major female sex hormone. It is involved in the regulation of the estrous and menstrual female reproductive cycles. Estradiol is responsible for the development of female secondary sexual characteristics such as the breasts, widening of the hips, and a feminine pattern of fat distribution in women and is important in the development and maintenance of female reproductive tissues such as the mammary glands, uterus, and vagina during puberty, adulthood, and pregnancy. It also has important effects in many other tissues including bone, fat, skin, liver, and the brain. Though estradiol levels in men are much lower compared to those in women, estradiol has important roles in men as well. Aside from humans and other mammals, estradiol is also found in most vertebrates and crustaceans, insects, fish, and other animal species.

Estradiol is produced especially within the follicles of the ovaries, but also in other tissues including the testicles, the adrenal glands, fat, liver, the breasts, and the brain. Estradiol is produced in the body from cholesterol through a series of reactions and intermediates. The major pathway involves the formation of androstenedione, which is then converted by aromatase into estrone and is subsequently converted into estradiol. Alternatively, androstenedione can be aromatized into testosterone, which can then be converted into estradiol. Upon menopause in women, production of estrogens by the ovaries stops and estradiol levels decrease to very low levels.

Estradiol acts primarily as an agonist of the estrogen receptor (ER), a nuclear steroid hormone receptor. There are two subtypes of the ER, ERα and ERβ, and estradiol potently binds to and activates both of these receptors. The result of ER activation is a modulation of gene transcription and expression in ER-expressing cells, which is the predominant mechanism by which estradiol mediates its biological effects in the body. Estradiol also acts as an agonist of membrane estrogen receptors (mERs), such as GPER (GPR30), a recently discovered non-nuclear receptor for estradiol, via which it can mediate a variety of rapid, non-genomic effects. Unlike the case of the ER, GPER appears to be selective for estradiol, and shows very low affinities for other endogenous estrogens, such as estrone and estriol.[39] Additional mERs besides GPER include ER-X, ERx, and Gq-mER.

Estradiol, like other steroid hormones, is derived from cholesterol. After side chain cleavage and using the Δ5 or the Δ4- pathway, androstenedione is the key intermediary. A portion of the androstenedione is converted to testosterone, which in turn undergoes conversion to estradiol by aromatase. In an alternative pathway, androstenedione is aromatized to estrone, which is subsequently converted to estradiol via 17β-hydroxysteroid dehydrogenase (17β-HSD).

Estradiol is an estrane steroid. It is also known as 17β-estradiol (to distinguish it from 17α-estradiol) or as estra-1,3,5(10)-triene-3,17β-diol. It has two hydroxyl groups, one at the C3 position and the other at the 17β position, as well as three double bonds in the A ring. Due to its two hydroxyl groups, estradiol is often abbreviated as E2. The structurally related estrogens, estrone (E1), estriol (E3), and estetrol (E4) have one, three, and four hydroxyl groups, respectively.

LEAPChem is continually expanding its scope within the pharmaceutical chemicals industry. Our passion for professional development enables us to accommodate our customers’ chemical requirements, and to distribute chemicals with applications that span several classes and functions.

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 References:

https://en.wikipedia.org/wiki/Estradiol

https://www.ncbi.nlm.nih.gov/pubmed/11511861

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754262/

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LEAPChem Has Acrylamide (79-06-1) Now!

If you are interested in Acrylamide, look no further than LEAPChem - Pharmaceutical Chemicals. We are an ISO:9001 certified organization attesting to the highest quality management practices in the pharmaceutical chemicals industry. Our professional team of technical specialists, logistics, compliance and customer service experts will provide a safe, time efficient, and cost-effective process from manufacturer to delivery at the port or warehouse of your choice. LEAPChem Highlights Acrylamide today!

 Basic Information of Acrylamide

Chemical Name: Acrylamide

Cas No.: 79-06-1

Molecular Formula: C3H5NO

Chemical Structure:

  Acrylamide (or acrylic amide) is a chemical compound with the chemical formula C3H5NO. Its IUPAC name is prop-2-enamide. It is a white odorless crystalline solid, soluble in water, ethanol, ether, and chloroform. Acrylamide decomposes in the presence of acids, bases, oxidizing agents, iron, and iron salts. It decomposes non-thermally to form ammonia, and thermal decomposition produces carbon monoxide, carbon dioxide, and oxides of nitrogen.

Acrylamide can be prepared by the hydrolysis of acrylonitrile by nitrile hydratase. In industry, most acrylamide is used to synthesize polyacrylamides, which find many uses as water-soluble thickeners. These include use in wastewater treatment, gel electrophoresis (SDS-PAGE), papermaking, ore processing, tertiary oil recovery, and the manufacture of permanent press fabrics. Some acrylamide is used in the manufacture of dyes and the manufacture of other monomers.

The discovery of acrylamide in some cooked starchy foods in 2002 prompted concerns about the carcinogenicity of those foods. As of 2017 it is still not clear whether acrylamide consumption affects people's risk of developing cancer.

The majority of acrylamide is used to manufacture various polymers. In the 1970s and 1980s, the proportionately largest use of these polymers was in water treatment. Additional uses include as binding, thickening or flocculating agents in grout, cement, sewage/wastewater treatment, pesticide formulations, cosmetics, sugar manufacturing, soil erosion prevention, ore processing, food packaging, plastic products, and paper production. Polyacrylamide is also used in some potting soil. Another use of polyacrylamide is as a chemical intermediate in the production of N-methylol acrylamide and N-butoxyacrylamide.

LEAPChem combines experience and expertise in the distribution of hazardous and non-hazardous raw materials to its professional customer base. Working alongside an elite network of manufacturers, carriers and warehouses, we are equipped to deliver your product safely and efficiently, throughout every step of the supply chain.

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 References:

https://en.wikipedia.org/wiki/Acrylamide

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164905/

https://www.ncbi.nlm.nih.gov/pubmed/17492525

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Source High Quality Guanidine hydrochloride (50-01-1) from LEAPChem!

LEAPChem - Pharmaceutical Chemicals is an ISO:9001 certified organization, which shows our high reputation track record for providing high quality management in the pharmaceutical chemicals industry. From initial inquiry through safe and efficient delivery, our team has the experience and professionalism to secure any pharmaceutical chemicals in your preferred grade, pack size and pack form, and deliver your products accurately, on time and on budget to every corner of the world. LEAPChem Highlights Guanidine hydrochloride today!

 Basic Information of Guanidine hydrochloride

Chemical Name: Guanidine hydrochloride

Cas No.: 50-01-1

Molecular Formula: CH5N3.HCl

Chemical Structure:

  Guanidinium chloride or guanidine hydrochloride, usually abbreviated GuHCl and sometimes GdnHCl or GdmCl, is the hydrochloride salt of guanidine. Guanidinium chloride is a strong chaotrope and one of the strongest denaturants used in physiochemical studies of protein folding. Guanidine Hydrochloride also has the ability to decrease enzyme activity and increase the solubility of hydrophobic molecules. At high concentrations of guanidinium chloride (e.g., 6 M), proteins lose their ordered structure, and they tend to become randomly coiled, i.e. they do not contain any residual structure. However, at concentrations in the millimolar range in vivo, guanidinium chloride has been shown to "cure" prion positive cells (i.e. cells exhibiting a prion positive phenotype revert to a prion negative phenotype). This is the result of inhibition of the Hsp104 chaperone protein known to play an important role in prion fiber fragmentation and propagation.

Guanidine hydrochloride is indicated for the reduction of the symptoms of muscle weakness and easy fatigability associated with Eaton-Lambert syndrome. It is not indicated for treating myasthenia gravis. It apparently acts by enhancing the release of acetylcholine following a nerve impulse. It also appears to slow the rates of depolarization and repolarization of muscle cell membranes. Initial dosage is usually between 10 and 15 mg/kg (5 to 7 mg/pound) of body weight per day in 3 or 4 divided doses. This dosage may be gradually increased to a total daily dosage of 35 mg/kg (16 mg/pound) of body weight per day or up to the development of side effects. Side effects include increased peristalsis and diarrhea. Fatal bone-marrow suppression, apparently dose related, can occur with guanidine.

As an experienced supplier of pharmaceutical chemicals for more than 10 years, LEAPChem is fully equipped to fill your pharmaceutical chemical requirements efficiently and exceed your expectations. Our customer service team is always ready to provide a personal touch to every conversation and ensure quick reply, professional support, and reliability at every step.

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 References:

https://en.wikipedia.org/wiki/Guanidinium_chloride

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2142645/

https://www.ncbi.nlm.nih.gov/pubmed/19594171

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LEAPChem Highlights Gentamicin sulfate (1405-41-0)!

LEAPChem - Pharmaceutical Chemicals is a premier supplier of pharmaceutical chemicals and other chemical raw materials for global customers including drug manufacturers, universities, research labs, R&D centers, and other industries that use chemical raw materials such as polymers, textiles, agriculture, coatings, etc. As an ISO 9001:2015 certified company, our team of experts in customer service, product sourcing, logistics, regulatory and compliance operate at the highest standard. LEAPChem's experienced sales team will work tirelessly to find the chemicals you need for a price you can afford. LEAPChem Highlights Gentamicin sulfate today!

 Basic Information of Gentamicin sulfate

Chemical Name: Gentamicin sulfate

Cas No.: 1405-41-0

Molecular Formula: C21H43N5O7

Chemical Structure:

  Gentamicin, sold under brand names Garamycin among others, is an antibiotic used to treat several types of bacterial infections. This may include bone infections, endocarditis, pelvic inflammatory disease, meningitis, pneumonia, urinary tract infections, and sepsis among others. It is not effective for gonorrhea or chlamydia infections. It can be given intravenously, by injection into a muscle, or topically. Topical formulations may be used in burns or for infections of the outside of the eye. In the developed world it is often only used for two days until bacterial cultures determine what antibiotics the infection is sensitive to. The dose required should be monitored by blood testing.

Gentamicin can cause inner ear problems and kidney problems. The inner ear problems can include problems with balance and problems with hearing. These problems may be permanent. If used during pregnancy it can cause harm to the baby. It appears to be safe for use during breastfeeding. Gentamicin is a type of aminoglycoside. It works by stopping the bacteria from making protein, which typically kills the bacteria.

Gentamicin is also used in combination with other antibiotics to treat infections caused by gram positive organisms such as Staphylococcus aureus and certain species of streptococci. Additionally, gentamicin is used in combination with a penicillin antibiotic to treat endocarditis (infection of the heart).

Gentamycin forms part of the aminoglycoside group of antibiotics. It kills bacteria as a result of abnormal protein production in the bacterial cell (that is, it cannot produce any of its proteins correctly) and also as a result of damage to the bacterial cell membrane.

Gentamicin injection is used to treat certain serious infections that are caused by bacteria such as meningitis (infection of the membranes that surround the brain and spinal cord) and infections of the blood, abdomen (stomach area), lungs, skin, bones, joints, and urinary tract.

As an industry leader in chemical sourcing, LEAPChem has strong relationships with vendors, suppliers, and customers worldwide that allow us to access hard to find chemicals at competitive prices. Our warehouses are equipped to handle kosher, organic, hazardous, and non-hazardous materials. We have established partnerships with import and export providers making seamless international shipping possible.

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Make LEAPChem your pharmaceutical chemicals long-term partner and contact us today!

 References:

https://en.wikipedia.org/wiki/Gentamicin

https://www.ncbi.nlm.nih.gov/m/pubmed/860719

https://www.ncbi.nlm.nih.gov/pubmed/4992660

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Source Potassium tert-butanolate (865-47-4) from LEAPChem!

LEAPChem - Pharmaceutical Chemicals is an ISO:9001 certified organization, which shows our high reputation track record for providing high quality management in the pharmaceutical chemicals industry. From initial inquiry through safe and efficient delivery, our team has the experience and professionalism to secure any pharmaceutical chemicals in your preferred grade, pack size and pack form, and deliver your products accurately, on time and on budget to every corner of the world. LEAPChem Highlights Potassium tert-butanolate today!

 Basic Information of Potassium tert-butanolate

Chemical Name: Potassium tert-butanolate

Cas No.: 865-47-4

Molecular Formula: C4H9KO

Chemical Structure:

  Potassium tert-butoxide is the chemical compound with the formula K+(CH3)3CO−. This colourless solid is a strong base (pKa of conjugate acid around 17), which is useful in organic synthesis. It exists as a tetrameric cubane-type cluster. It is often seen written in chemical literature as potassium t-butoxide. The compound is often depicted as a salt, and it often behaves as such, but it is not ionized in solution.

The tert-butoxide species is itself useful as a strong, non-nucleophilic base in organic chemistry. It is not as strong as amide bases, e.g. lithium diisopropylamide, but stronger than potassium hydroxide. Its steric bulk inhibits the group from participating in nucleophilic addition, such as in a Williamson ether synthesis or an SN2 reaction. Substrates that are deprotonated by potassium t-butoxide include terminal acetylenes and active methylene compounds. It is useful in dehydrohalogenation reactions.

Potassium tert-butoxide catalyzes the reaction of hydrosilanes and heterocyclic compounds to give the silyl derivatives, with release of H2.

Many modifications have been reported that influence the reactivity of this reagent. The compound adopts a complex cluster structure (the adjacent picture is a simplified cartoon), and additives that modify the cluster affect the reactivity of the reagent. For example, DMF, DMSO, hexamethylphosphoramide (HMPA), and 18-crown-6 interact with the potassium center, enhancing the basicity of the butoxide. Schlosser's base, a mixture of the alkoxide and an alkyl lithium compound, is a related but stronger base.

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 References:

https://en.wikipedia.org/wiki/Potassium_tert-butoxide

https://www.ncbi.nlm.nih.gov/pubmed/26397119

https://pubchem.ncbi.nlm.nih.gov/compound/Potassium_tert-butoxide

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Find High Quality alpha-Arbutin (84380-01-8) from LEAPChem!

At LEAPChem - Pharmaceutical Chemicals, we proudly supply the materials that are required for the wide range of our customers’ production processes. We understand that each production process is unique, which is why we provide custom services and chemical knowledge tailored to each customer specifically. With LEAPChem, you can look forward to receiving the operational benefits of working with an international company paired with the customer service and reliable follow up of a small business. LEAPChem Highlights alpha-Arbutin today!

 Basic Information of alpha-Arbutin

Chemical Name: alpha-Arbutin

Cas No.: 84380-01-8

Molecular Formula: C12H16O7

Chemical Structure:

  Arbutin is a glycoside; a glycosylated hydroquinone extracted from the bearberry plant in the genus Arctostaphylos among many other medicinal plants, primarily in the Ericaceae family. Applied topically, it inhibits tyrosinase and thus prevents the formation of melanin. Arbutin is therefore used as a skin-lightening agent. Very tiny amounts of arbutin are found in wheat, pear skins, and some other foods. It is also found in Bergenia crassifolia. Arbutin was also produced by an in vitro culture of Schisandra chinensis.

It works by slowly releasing hydroquinone through hydrolysis, which in turn blocks Tyrosinase activity and reduces the skin’s melanin (pigmentation) production. In cosmetics, this ingredient appears in two different forms: Alpha-Arbutin or Beta-Arbutin. Due to patenting concerns, most skin care products contain plant extracts that contain Arbutin (e.g. bearberry, pear, blueberry), rather than pure Arbutin. Used in a variety of cosmetics, particularly ones aimed at lightening the skin such as lotions, crèmes, serums, cleansers, and spot treatments.

Bearberry extract is used in skin lightening treatments designed for long term and regular use. An active agent in brands of skin lightening preparations, it is more expensive than traditional skin lightening ingredients like hydroquinone, which is now banned in many countries. In vitro studies of human melanocytes exposed to arbutin at concentrations below 300 μg/mL reported decreased tyrosinase activity and melanin content with little evidence of cytotoxicity.

 As an industry leader in chemical sourcing, LEAPChem has strong relationships with vendors, suppliers, and customers worldwide that allow us to access hard to find chemicals at competitive prices. Our warehouses are equipped to handle kosher, organic, hazardous, and non-hazardous materials. We have established partnerships with import and export providers making seamless international shipping possible.

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 References:

https://en.wikipedia.org/wiki/Arbutin

https://www.ncbi.nlm.nih.gov/pubmed/15056856

https://www.ncbi.nlm.nih.gov/pubmed/8632348

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LEAPChem Highlights 2-Cyclohexen-1-one (930-68-7) Today!

Searching for niche products has always been a problem. You have to spend much valuable time looking for a supplier, and then you need to make sure the provider is reputable. Usually, successfully finding a reputable, reliable, and responsible supplier of high quality chemicals must be a headache. Relax now, because those days are over! By coming to the LEAPChem - Pharmaceutical Chemicals website, you have come one step closer to acquiring your trouble free pharmaceutical chemicals. LEAPChem Highlights 2-Cyclohexen-1-one today!

 Basic Information of 2-Cyclohexen-1-one

Chemical Name: 2-Cyclohexen-1-one

Cas No.: 930-68-7

Molecular Formula: C6H8O

Chemical Structure:

  Cyclohexenone is an organic compound which is a versatile intermediate used in the synthesis of a variety of chemical products such as pharmaceuticals and fragrances. It is clear colorless liquid in pure state but a commercially available product is mostly yellowish liquid.

Industrially, cyclohexenone is prepared from phenol by Birch reduction. Cyclohexenone is a ketone, or more precisely an enone. Common reactions include nucleophilic conjugate addition with organocopper reagents, Michael reactions and Robinson annulations.

It is soluble in many solvents, such as alcohols, ethers, haloalkanes, esters, and also is miscible with polar aprotic solvents. Cyclohexenone reacts both ketones and alkenes. It has an electron-poor carbon-carbon double bond as a typical representative of the α, β-unsaturated carbonyl compounds. With strong bases, the positions 4 and 6 (the two CH2-groups of the carbonyl group and the C-C double bond adjacent) are deprotonated.

Cyclohexenone is a widely used building block in organic synthesis chemistry, as it offers many different ways to extend molecular frameworks. Cyclohexenone is easily adapted to Michael addition with nucleophiles (such as enolates or silyl enol ethers) or, it could be employed by a Diels-Alder reaction with electron-rich dienes. Furthermore, this compound reacts with organocopper compounds from 1,4-addition (Michael addition), or with Grignard reagents 1,2-addition, i.e., with attack of the nucleophile at the carbonyl carbon atom. Cyclohexenone is also used in multi-step synthesis in the construction of polycyclic natural products.

Cyclohexenone was accidentally found to be an in-vitro catalyst for a relatively mild decarboxylation of alpha amino acids in 1986. Researchers in Japan were attempting to use t-butyl peroxide as a catalyst for decarboxylation using a solvent choice of cyclohexanol. Curiously they found that when they used lower-purity (e.g. technical grade, 98%) cyclohexanol, the reaction proceeded as much as 4 times faster compared to when they used relatively pure cyclohexanol (>99.3%). They found that cyclohexanol contained cyclohexenone as a natural impurity, which was three times more abundant in the technical grade cyclohexenone compared to the more purified cyclohexanol (~0.3% versus ~0.1%). Further research showed that 1% cyclohexenone in cyclohexanol will decarboxylate most alpha-amino acids, including non-standard ones, with a yield of 80-95% in a matter of several hours. The exceptions are certain amino acids like histidine, which was reported to take over 26 hours, and poly-amino acids, which fail to decarboxylate using 2-cyclohexenone and another route must be found instead.

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 References:

https://en.wikipedia.org/wiki/Cyclohexenone

https://pubchem.ncbi.nlm.nih.gov/compound/2-cyclohexen-1-one

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Buy High Quality Diclofenac sodium (15307-79-6) from LEAPChem!

If you are interested in Diclofenac sodium or its derivatives, look no further than LEAPChem - Pharmaceutical Chemicals. We are an ISO:9001 certified organization attesting to the highest quality management practices in the pharmaceutical chemicals industry. Our professional team of technical specialists, logistics, compliance and customer service experts will provide a safe, time efficient, and cost-effective process from manufacturer to delivery at the port or warehouse of your choice. LEAPChem Highlights Diclofenac sodium today!

 Basic Information of Diclofenac sodium

Chemical Name: Diclofenac sodium

Cas No.: 15307-79-6

Molecular Formula: C14H11Cl2NO2

Chemical Structure:

  Diclofenac (sold under a number of trade names) is a nonsteroidal anti-inflammatory drug (NSAID) taken or applied to reduce inflammation and as an analgesic reducing pain in certain conditions. It is supplied as or contained in medications under a variety of trade names. Diclofenac is used to treat pain, inflammatory disorders, and dysmenorrhea.

Diclofenac and misoprostol combination is used to relieve symptoms of arthritis (eg, osteoarthritis or rheumatoid arthritis) in patients who may develop stomach ulcers from taking nonsteroidal anti-inflammatory drugs (NSAIDs).

Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID), used to relieve symptoms of arthritis such as inflammation, swelling, stiffness, and joint pain. Misoprostol is used to decrease the chance of having stomach and intestinal ulcers.

Inflammatory disorders may include musculoskeletal complaints, especially arthritis, rheumatoid arthritis, polymyositis, dermatomyositis, osteoarthritis, dental pain, temporomandibular joint (TMJ) pain, spondylarthritis, ankylosing spondylitis, gout attacks, and pain management in cases of kidney stones and gallstones. An additional indication is the treatment of acute migraines. Diclofenac is used commonly to treat mild to moderate postoperative or post-traumatic pain, in particular when inflammation is also present, and is effective against menstrual pain and endometriosis.

Diclofenac is also available in topical forms and has been found to be useful for osteoarthritis but not other types of long-term musculoskeletal pain.

It may also help with actinic keratosis, and acute pain caused by minor strains, sprains, and contusions (bruises).

In many countries, eye drops are sold to treat acute and chronic nonbacterial inflammation of the anterior part of the eyes (e.g., postoperative states). Diclofenac eye drops have also been used to manage pain for traumatic corneal abrasion.

Diclofenac is often used to treat chronic pain associated with cancer, in particular if inflammation is also present (Step I of the World Health Organization (WHO) scheme for treatment of chronic pain). Diclofenac can be combined with opioids if needed such as a fixed combination of diclofenac and codeine.

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 References:

https://en.wikipedia.org/wiki/Diclofenac

https://www.ncbi.nlm.nih.gov/pubmed/2670397

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445819/

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LEAPChem is Proud to Offer Tetrabutyl titanate (5593-70-4)!

LEAPChem - Pharmaceutical Chemicals is an ISO:9001 certified organization, which shows our high reputation track record for providing high quality management in the pharmaceutical chemicals industry. From initial inquiry through safe and efficient delivery, our team has the experience and professionalism to secure any pharmaceutical chemicals in your preferred grade, pack size and pack form, and deliver your products accurately, on time and on budget to every corner of the world. LEAPChem Highlights Tetrabutyl titanate today!

 Basic Information of Tetrabutyl titanate

Chemical Name: Tetrabutyl titanate

Cas No.: 5593-70-4

Molecular Formula: C6H14N2O2

Chemical Structure:

  Titanium butoxide, also named Tetrabutyl titanate, is an chemical compound with the formula Ti(OBu)4 (Bu = CH2CH2CH2CH3). It is a colorless to pale-yellow liquid with a weak alcohol-like odor and density almost equal to that of water. It is soluble in most organic solvents, but decomposes in water and reacts violently with oxidizing materials. Decomposition in water is not hazardous, and therefore titanium butoxide is often used as a liquid source of titanium dioxide, which allows deposition of TiO2 coatings of various shapes and sizes down to the nanoscale.

Titanium butoxide is produced by reacting titanium tetrachloride with butanol. When mixed with water it decomposes to titanium dioxide and butanol. This decomposition is not hazardous, and is often used as a source of titanium dioxide.

Tetrabutyl orthotitanate reacts with alkylcyclosiloxanes. With ocatamethylcyclotetrasiloxane it produces dibutoxydimethylsilane, 1,5-dibutoxyhexamethyltrisiloxane, 1,7-dibutoxyoctamethyltetrasiloxane, 1,3-dibutoxytetramethyldisiloxane and polymers. With hexamethylcyclotrisiloxane it also produces dibutoxydimethylsilane.

Titanium butoxide is a corrosive, flammable liquid incompatible with oxidizing materials. It reacts violently with sulfuric and nitric acid, inorganic hydroxides and peroxides, bases, amines, amides, isocyanates and boranes. It is irritating to skin and eyes, and causes nausea and vomiting if swallowed. LD50 is 3122 mg/kg (rat, oral) and 180 mg/kg (mouse, intravenal); flash point is 77 °C. When heated it emits irritating fumes, which form explosive mixtures with air at concentrations above 2 vol%.

 As an experienced supplier of pharmaceutical chemicals for more than 10 years, LEAPChem is fully equipped to fill your pharmaceutical chemical requirements efficiently and exceed your expectations. Our customer service team is always ready to provide a personal touch to every conversation and ensure quick reply, professional support, and reliability at every step.

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 References:

https://en.wikipedia.org/wiki/Titanium_butoxide

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3211978/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747562/

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Source L-Lysine (56-87-1) from LEAPChem!

Searching for niche products has always been a problem. You have to spend much valuable time looking for a supplier, and then you need to make sure the provider is reputable. Usually, successfully finding a reputable, reliable, and responsible supplier of high quality chemicals must be a headache. Relax now, because those days are over! By coming to the LEAPChem - Pharmaceutical Chemicals website, you have come one step closer to acquiring your trouble free pharmaceutical chemicals. LEAPChem Features L-Lysine today!

 Basic Information of L-Lysine

Chemical Name: L-Lysine

Cas No.: 56-87-1

Molecular Formula: C6H14N2O2

Chemical Structure:

  Lysine (symbol Lys or K), encoded by the codons AAA and AAG, is an α-amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated −NH3+ form under biological conditions), an α-carboxylic acid group (which is in the deprotonated −COO− form under biological conditions), and a side chain lysyl ((CH2)4NH2), classifying it as a charged (at physiological pH), aliphatic amino acid. It is essential in humans, meaning the body cannot synthesize it and thus it must be obtained from the diet.

Lysine is a base, as are arginine and histidine. The ε-amino group often participates in hydrogen bonding and as a general base in catalysis. The ε-ammonium group (NH3+) is attached to the fourth carbon from the α-carbon, which is attached to the carboxyl (C=OOH) group.

L-lysine plays a particularly important role in the immune system. It is involved in the development of antibodies and has important antiviral properties.

Studies show that this particular amino acid is especially beneficial for safeguarding against herpes virus. Lysine has been shown to decrease occurrences of anxiety1 and it assists with the formation of collagen and muscle tissue.

It is also involved in protein biosynthesis, especially in building collagen together with the amino acids Glycine and Proline. An L-lysine deficiency may therefore result in broken skin, fragile nails and in extreme cases loss of hair.

There is also evidence that L-lysine increases the effectiveness of L-arginine in promoting human growth hormone (HGH) release. Suminski and colleagues found that HGH was increased when weightlifters ingested Arginine and Lysine without exercise2.

 As an industry leader in chemical sourcing, LEAPChem has strong relationships with vendors, suppliers, and customers worldwide that allow us to access hard to find chemicals at competitive prices. Our warehouses are equipped to handle kosher, organic, hazardous, and non-hazardous materials. We have established partnerships with import and export providers making seamless international shipping possible.

If you are interested in L-Lysine, click here to send an inquiry!

Make LEAPChem your pharmaceutical chemicals long-term partner and contact us today!

 References:

https://en.wikipedia.org/wiki/Lysine

https://www.ncbi.nlm.nih.gov/pubmed/17510493

https://www.ncbi.nlm.nih.gov/pubmed/1486246

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LEAPChem Features Doxorubicin hydrochloride (25316-40-9)!

LEAPChem - Pharmaceutical Chemicals is an ISO:9001 certified organization, which shows our high reputation track record for providing high quality management in the pharmaceutical chemicals industry. From initial inquiry through safe and efficient delivery, our team has the experience and professionalism to secure any pharmaceutical chemicals in your preferred grade, pack size and pack form, and deliver your products accurately, on time and on budget to every corner of the world. LEAPChem Features Doxorubicin hydrochloride today!

 Basic Information of Doxorubicin hydrochloride

Chemical Name: Doxorubicin hydrochloride

Cas No.: 25316-40-9

Molecular Formula: C27H29NO11

Chemical Structure:

  Doxorubicin, sold under the trade names Adriamycin among others, is a chemotherapy medication used to treat cancer. This includes breast cancer, bladder cancer, Kaposi's sarcoma, lymphoma, and acute lymphocytic leukemia. It is often used together with other chemotherapy agents. Doxorubicin is given by injection into a vein.

Common side effects include hair loss, bone marrow suppression, vomiting, rash, and inflammation of the mouth. Other serious side effects may include allergic reactions such as anaphylaxis, heart damage, tissue damage at the site of injection, radiation recall, and treatment-related leukemia. People often experience red discoloration of the urine for a few days. Doxorubicin is in the anthracycline and antitumor antibiotic family of medications. It works in part by interfering with the function of DNA.

Doxorubicin is commonly used to treat some leukemias and Hodgkin's lymphoma, as well as cancers of the bladder, breast, stomach, lung, ovaries, thyroid, soft tissue sarcoma, multiple myeloma, and others. Commonly used doxorubicin-containing regimens are AC (adriamycin, cyclophosphamide), TAC (taxotere, AC), ABVD (Adriamycin, bleomycin, vinblastine, dacarbazine), BEACOPP, CHOP (cyclophosphamide, hydroxydaunorubicin, vincristine, prednisone) and FAC (5-fluorouracil, adriamycin, cyclophosphamide).

Doxil is used primarily for the treatment of ovarian cancer where the disease has progressed or recurred after platinum-based chemotherapy, or for the treatment of AIDS-related Kaposi's sarcoma.

 LEAPChem combines experience and expertise in the distribution of hazardous and non-hazardous raw materials to its professional customer base. Working alongside an elite network of manufacturers, carriers and warehouses, we are equipped to deliver your product safely and efficiently, throughout every step of the supply chain.

If you are interested in Doxorubicin hydrochloride, click here to send an inquiry!

Make LEAPChem your pharmaceutical chemicals long-term partner and contact us today!

 References:

https://en.wikipedia.org/wiki/Doxorubicin

https://www.ncbi.nlm.nih.gov/pubmed/24211979

https://www.ncbi.nlm.nih.gov/pubmed/4009823

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