literallyaurl

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Fujoshi wife fills her house with chintz knowingly

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"history will absolve me" as the e-mail signature

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top ten signs the heavy machinery likes you back

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”I have this artistic idea but not the skills to achieve it to the standard I want.”

congrats! Now you have a motif! A recurring theme! A focus for your art! Something to haunt you!

Seventeen still lives of dandelions? Three hundred poems about grief? A sketchbook dedicated to your grandmother’s house? Two books trying to unravel the complexities of familial relationships?

Don’t let the fear of it not being perfect on the first try stop you from being Weird About It!

[literallyaurl]

warm innit

[literallyaurl]

work should be illegal and everyone should be drunk at the park

[literallyaurl]

The problem with playing smash or pass is that there's a lot of characters which I'm not sexually attracted to but I would fuck in a heartbeat out of sheer curiosity and ego, like I don't find Mickey Mouse attractive at all but if he approached me at a bar and went "Hey sexy, want me to show you my mouseketool?" I would say yes because then I get to tell my friends I fucked Mickey Mouse

[literallyaurl]

very much a fan of this post so i felt compelled to make my own. print it out and give it to your coworkers or hang it in your cubicle and go "don't make me tap the sign"

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2027: Wizards of the Coast and the American Psychological Association collaborate on the D&DSM, 6th Edition, widely regarded as the worst thing ever published

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person in fandom: eeeyikes!!! i hope im writing this character in this short little fanfic right >_< eeekkk what if my takes on my meta are all wrong and everyone will Kill me!!

guy in professional comic industry: okay lets mischaracterize every single character that appears in this comic for 50 or so issues

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Source

[literallyaurl]

Sydney & Luca + glances I can't stop thinking about

THE BEAR (2022—) 3.10 | Forever

[literallyaurl]

I'm coming to realize how vital it is to keep a running list of shit you did in the past few weeks so that you can participate in small talk. It's literally not anything to do with them being interesting at all it's just having Something to say to give people even the barest thing to hold on to. It's so you don't get into the "what have you been up to" "nothing much what about you" "yeah same" trap. Literally just say something.

What have you been up to? Um well it's getting warmer so I've been having to brush my cat every day.

Like no it's not that interesting of a thing to say. But now they can respond to it. They could say, man yeah it really is heating up, I've been trying to think of things to do inside more often. Or, oh you have a cat? What's their name?

Like. It's Something. All you need is Something. And if you're like me and your brain immediately goes blank upon entering small talk then keeping a list will help you remember things to say.

[literallyaurl]

VII - THE CHARIOT

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Nexus Mods was acquired by Chosen, a company focused on growth and monetization of gaming startups.

Reddit thread

Dark0ne, creator and ex-owner of Nexus Mods, stepped down today in an update post:

NexusMods post

Users on Resetera were able to found out more about this sudden change of ownership:

Resetera thread

Victor Folmann, CEO of Chosen, published this "Gaming Startup Monetization Cheat Sheet" on his LinkedIn

Link to the post

Users are already sharing their fear of NexusMods allowing more bigoted mods in the future, and taking down inclusive ones to follow the current "anti-woke" trend in the gaming industry

Reseta threada bout their change in moderation concerning bigoted mods following Oblivion Remastered launch

Another User, this time on NexusMods forum, noticed queer and inclusive mods being removed following Dark0ne's post

Link to the forum post

It is also worth mentioning that Chosen and its CEO are seen using AI generated images on their website (including generated images depicting Tracer from Overwatch) hyping up ChatGPT on his Linkedin account, and are including "rewarding gamers with crypto money"

Users speculate that Chosen buying out NexusMods is to potentially train an AI model that generates mods

More about Nvidia's AI "RTX Remix" and future projects

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"A cure for HIV could be a step closer after researchers found a new way to force the virus out of hiding inside human cells.

The virus’s ability to conceal itself inside certain white blood cells has been one of the main challenges for scientists looking for a cure. It means there is a reservoir of the HIV in the body, capable of reactivation, that neither the immune system nor drugs can tackle.

Now researchers from the Peter Doherty Institute for Infection and Immunity in Melbourne, have demonstrated a way to make the virus visible, paving the way to fully clear it from the body.

It is based on mRNA technology, which came to prominence during the Covid-19 pandemic when it was used in vaccines made by Moderna and Pfizer/BioNTech.

In a paper published in Nature Communications, the researchers have shown for the first time that mRNA can be delivered into the cells where HIV is hiding, by encasing it in a tiny, specially formulated fat bubble. The mRNA then instructs the cells to reveal the virus.

Globally, there are almost 40 million people living with HIV, who must take medication for the rest of their lives in order to suppress the virus and ensure they do not develop symptoms or transmit it. For many it remains deadly, with UNAids figures suggesting one person died of HIV every minute in 2023.

It was “previously thought impossible” to deliver mRNA to the type of white blood cell that is home to HIV, said Dr Paula Cevaal, research fellow at the Doherty Institute and co-first author of the study, because those cells did not take up the fat bubbles, or lipid nanoparticles (LNPs), used to carry it.

The team have developed a new type of LNP that those cells will accept, known as LNP X. She said: “Our hope is that this new nanoparticle design could be a new pathway to an HIV cure.”

When a colleague first presented test results at the lab’s weekly meeting, Cevaal said, they seemed too good to be true.

“We sent her back into the lab to repeat it, and she came back the next week with results that were equally good. So we had to believe it. And of course, since then, we’ve repeated it many, many, many more times.

“We were overwhelmed by how [much of a] night and day difference it was – from not working before, and then all of a sudden it was working. And all of us were just sitting gasping like, ‘wow’.”

Further research will be needed to determine whether revealing the virus is enough to allow the body’s immune system to deal with it, or whether the technology will need to be combined with other therapies to eliminate HIV from the body.

The study is laboratory based and was carried out in cells donated by HIV patients. The path to using the technology as part of a cure for patients is long, and would require successful tests in animals followed by safety trials in humans, likely to take years, before efficacy trials could even begin.

“In the field of biomedicine, many things eventually don’t make it into the clinic – that is the unfortunate truth; I don’t want to paint a prettier picture than what is the reality,” stressed Cevaal. “But in terms of specifically the field of HIV cure, we have never seen anything close to as good as what we are seeing, in terms of how well we are able to reveal this virus.

“So from that point of view, we’re very hopeful that we are also able to see this type of response in an animal, and that we could eventually do this in humans.”

Dr Michael Roche of the University of Melbourne and co-senior author of the research, said the discovery could have broader implications beyond HIV, with the relevant white blood cells also involved in other diseases including cancers.

Dr Jonathan Stoye, a retrovirologist and emeritus scientist at the Francis Crick Institute, who was not involved in the study, said the approach taken by the Melbourne team appeared be a major advance on existing strategies to force the virus out of hiding, but further studies would be needed to determine how best to kill it after that.

He added: “Ultimately, one big unknown remains. Do you need to eliminate the entire reservoir for success or just the major part? If just 10% of the latent reservoir survives will that be sufficient to seed new infection? Only time will tell.

“However, that does not detract from the significance of the current study, which represents a major potential advance in delivery of mRNA for therapeutic purposes to blood cells.”"

-via The Guardian, June 5, 2025