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News and Events

2023 NOSTER & Science Microbiome Prize: Noster Inc and AAAS announce the grand winner and finalists of the 2023 NOSTER & Science Microbiome Prize

News release

GRAND PRIZE WINNER

Sara Clasen

Sara Clasen of the Max Planck Institute for Biology in Tübingen, Germany, is the recipient of the 2023 NOSTER & Science Microbiome Grand Prize for her essay entitled, “The sound of silence".

Details about the prize-winning essay

Essay: The sound of silence

Science, 381, 6653, pp. 37-38,  2023

DOI: 10.1126/science.adi6265

Related research

Clasen SJ, Bell MEW, Borbón A, Lee DH, Henseler ZM, de la Cuesta-Zuluaga J, Parys K, Zou J, Wang Y, Altmannova V, Youngblut ND, Weir JR, Gewirtz AT, Belkhadir Y, Ley RE.

Silent recognition of flagellins from human gut commensal bacteria by Toll-like receptor 5.

Sci Immunol. 2023 Jan 6;8(79):eabq7001.

MicrobiomeResearchX Podcast

Finalist

Christopher Stewart

Christopher Stewart of the Translational and Clinical Research Institute at Newcastle University, is a finalist of the 2023 NOSTER & Science Microbiome Prize for his essay entitled "Diet-microbe-host interaction in early life: breastmilk bioactives are important to infant microbiome.”  

Details about the prize-winning essay

Essay: Diet-microbe-host interaction in early life

Science, 381, 6653, p. 38, (2023)

DOI: 10.1126/science.adi6318

Related research

C. J Stewart et al, Temporal development of the gut microbiome in early childhood from the TEDDY study.

Nature 562 (7728): 583-588, (2018).

DOI: 10.1038/s41586-018-0617-x.

MicrobiomeResearchX Podcast

Finalist

Christoph A. Thaiss

Christoph A. Thaiss the Microbiology Department of the Perelman School of Medicine at the University of Pennsylvania, is a finalist of the 2023 NOSTER & Science Microbiome Prize for his essay entitled "A microbiome exercise: gut-brain connections drive the motivation to work out.”  

Details about the prize-winning essay

Essay: A microbiome exercise

Science, 381, 6653, p. 38, 2023.

DOI: 10.1126/science.adi6329

Related research

L. Dohnalová et al A microbiome-dependent gut-brain pathway regulates motivation for exercise.

Nature, 612(7941):739-747, 2022.

DOI: 10.1038/s41586-022-05525-z. E

MicrobiomeResearchX Podcast

[nkhealth]

Welcome to the MRX Podcast. Insightful conversations with scientists actively pursuing research on the human microbiome.

Season three Episode one 

Jennifer Hampton Hill: Grand Prize winner of the 2022 NOSTER & Science Microbiome Prize

Our guest today is Jennifer Hampton Hill, University of Utah is the recipient of the 2022 NOSTER & Science Microbiome Grand Prize for her work that “revealed that the resident microbiome is a promising source of previously undiscovered modulators of host β cells.”

Links to the platforms hosting the Microbiome ResearchX Podcast

Apple podcasts

https://podcasts.apple.com/us/podcast/the-microbiomeresearchx-mrx-podcast/id1541525939

Spotify 

https://open.spotify.com/episode/2MZzgXZJLJmhhnB9c1Wt47?si=Bawp_bYmRF-t_wIVONiVYA

Google Podcasts

https://podcasts.google.com?feed=aHR0cHM6Ly9mZWVkcy5idXp6c3Byb3V0LmNvbS8xNTA0NzY1LnJzcw%3D%3D&episode=QnV6enNwcm91dC0xMTYzNDk1MQ%3D%3D

 Links to details about the prize-winning essay

https://www.science.org/content/page/2022-noster-science-prize-winners

Essay: From bugs to β cells

SCIENCE, 7 Jul 2022, Vol 377, Issue 6602, pp. 164-165 DOI: 10.1126/science.abq6051

https://www.science.org/doi/10.1126/science.abq6051

Latest research

Jennifer Hampton Hill, Michelle Sconce Massaquoi, Emily Goers Sweeney, Elena S. Wall, Philip Jahl, Rickesha Bell, Karen Kallio, Daniel Derrick, L. Charles Murtaugh, Raghuveer Parthasarathy, S. James Remington, June L. Round, Karen Guillemin

 BefA, a microbiota-secreted membrane disrupter, disseminates to the pancreas and increases β cell mass

Cell Metabolism, 34, pp. 1779-1791.e9, (2022)

https://doi.org/10.1016/j.cmet.2022.09.001.

https://www.sciencedirect.com/science/article/pii/S1550413122003916

Media Coverage

U OF U HEALTH POSTDOCTORAL FELLOW EARNS PRESTIGIOUS NOSTER AND SCIENCE MICROBIOME PRIZE

https://uofuhealth.utah.edu/newsroom/news/2022/07/hill-noster-science-prize

 Jumpstarting insulin production with microbial diversity wins NOSTER & Science Microbiome Prize

https://www.eurekalert.org/news-releases/957641

  Jennifer Hampton Hill: Grand Prize winner of the 2022 NOSTER & Science Microbiome Prize

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News and Events

2022 NOSTER & Science Microbiome Prize: Noster Inc and AAAS announce the grand winner and finalists of the 2022 NOSTER & Science Microbiome Prize

News release 

https://www.science.org/content/page/2022-noster-science-prize-winners

GRAND PRIZE WINNER

Jennifer Hampton Hill at the University of Utah is the recipient of the 2022 NOSTER & Science Microbiome Prize for her work that “revealed that the resident microbiome is a promising source of previously undiscovered modulators of host β cells.”

https://www.science.org/content/page/2022-noster-science-prize-winners

Essay: From bugs to β cells

SCIENCE, 7 Jul 2022, Vol 377, Issue 6602, pp. 164-165 DOI: 10.1126/science.abq6051

https://www.science.org/doi/10.1126/science.abq6051

Finalist

Apollo Stacy, Cleveland Clinic Lerner Research Institute.

Essay: Remembrance of infections past

SCIENCE, 7 Jul 2022, Vol 377, Issue 6602, p. 165

DOI: 10.1126/science.abq6054

https://www.science.org/doi/10.1126/science.abq6054

 Finalist 

Irina Leonardi, Scientific Communications Lead at Immunai in New York. 

Essay: Beyond the gut

SCIENCE, 7 Jul 2022, Vol 377, Issue 6602, p. 165

DOI: 10.1126/science.abq6056 Further information

https://www.science.org/doi/10.1126/science.abq6056

Past winners

https://www.science.org/content/page/past-winners-noster-science-microbiome-prize

Information about the NOSTER and Science Microbiome Prize

https://www.science.org/content/page/noster-science-microbiome-prize-how-enter

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Noster  Science AAAS live webinar 27 April 2022 

Manipulating the microbiome: The impact of prebiotics, probiotics, and postbiotics on health and disease

During the webinar, the audience will:

Learn how the human microbiome impacts our health and can alter the course of disease

Discover the difference between prebiotics, probiotics, and postbiotics, and how they are being used to shape the microbiome

Hear about the latest research on the metabolic changes brought about by modifications to the microbiome

Be able to submit their questions to the speakers during the live broadcast.

This webinar will last for approximately 60 minutes.

Speakers

Amedeo Amedei, Ph.D.

University of Florence Florence, Italy

Jonathan Swann, Ph.D.

University of Southampton Southampton, UK

[nkhealth]

Welcome to the MRX Podcast. Insightful conversations with scientists actively pursuing research on the human microbiome.

Season two Episode three

Erez Baruch: Finalist of the 2021 NOSTER & Science Microbiome Prize

Our guest today is Erez Baruch, who recently started an internal medicine residency in a research (Physician-Scientist) track to medical oncology. Internal medicine training is conducted at the McGovern Medical School in Houston, Texas.

Erez is a finalist of the 2021 NOSTER & Science Microbiome Prize for his essay, "Microbiota modulation to fight cancer”, based on his research on “mechanisms of immunotherapy resistance and toxicity, modulation of the gut microbiota, and interaction between innate and adaptive immune cells”.

Links to the platforms hosting the Microbiome ResearchX Podcast

Apple podcasts

https://podcasts.apple.com/us/podcast/the-microbiomeresearchx-mrx-podcast/id1541525939

Spotify

https://open.spotify.com/show/29ya9FbPaQJ6BI2ntaAYwi

Google Podcasts

https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5idXp6c3Byb3V0LmNvbS8xNTA0NzY1LnJzcw==

Links to details about the prize-winning essay are available here

Summary of the research activities of the 2021 NOSTER & Science Microbiome Prize winners

https://www.aaas.org/news/gut-brain-axis-yields-clues-neurodegenerative-disease

Essay by Erez Baruch

https://www.science.org/doi/full/10.1126/science.abi9360

Erez Baruch

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Welcome to the MRX Podcast. Insightful conversations with scientists actively pursuing research on the human microbiome.

Season two Episode two 

Maria Zimmermann-Kogadeeva: Finalist of the 2021 NOSTER & Science Microbiome Prize

Our guest today is Maria Zimmermann-Kogadeeva, who started her lab in the Genome Biology Unit at EMBL Heidelberg in 2021.

Maria is a finalist of the 2021 NOSTER & Science Microbiome Prize for her essay, "Quantifying host-microbiota interactions” based on her research on the adaptation and consequences of microbes to their surroundings in hosts.

Links to the platforms hosting the Microbiome ResearchX Podcast

Apple podcasts

https://podcasts.apple.com/us/podcast/the-microbiomeresearchx-mrx-podcast/id1541525939

Spotify

https://open.spotify.com/show/29ya9FbPaQJ6BI2ntaAYwi

Google Podcasts

https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5idXp6c3Byb3V0LmNvbS8xNTA0NzY1LnJzcw==

Links to details about the prize-winning essay are available here

Summary of the research activities of the 2021 NOSTER & Science Microbiome Prize winners

https://www.aaas.org/news/gut-brain-axis-yields-clues-neurodegenerative-disease

Essay by Maria Zimmermann-Kogadeeva

https://www.science.org/doi/full/10.1126/science.abi9357

Maria Zimmermann-Kogadeeva

[nkhealth]

Welcome to the MRX Podcast. Insightful conversations with scientists actively pursuing research on the human microbiome.

Season two Episode one 

Eran Blacher: Grand Prize winner of the 2021 NOSTER & Science Microbiome Prize

Our guest today is Eran Blacher, who is currently a senior postdoctoral fellow at Stanford School of Medicine studying the immune system-gut-brain axis in ageing and neurological disorders.

Eran is the Grand Prize winner of the 2021 NOSTER & Science Microbiome Prize for his essay, “Can microbes combat neurodegeneration?” based on his research on the relationship between the microbiome and neurodegenerative diseases such as Alzheimer's disease.

Links to the platforms hosting the Microbiome ResearchX Podcast

Apple podcasts

https://podcasts.apple.com/us/podcast/the-microbiomeresearchx-mrx-podcast/id1541525939

Spotify 

https://open.spotify.com/show/29ya9FbPaQJ6BI2ntaAYwi

Google Podcasts

https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5idXp6c3Byb3V0LmNvbS8xNTA0NzY1LnJzcw==

Links to details about the prize-winning essay

Summary of the research activities of the 2021 NOSTER & Science Microbiome Prize winners

https://www.aaas.org/news/gut-brain-axis-yields-clues-neurodegenerative-disease

Essay by Eran Blacher

https://www.science.org/doi/full/10.1126/science.abi9353

Eran Blacher, Ph.D., Stanford University, Stanford, CA

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News and Events 

NOSTER SPONSORS LIVE AAAS SCIENCE WEBINAR on  1 September 2021 at 12:00 p.m. ET for 60 minutes

Mapping the microbiota–gut–brain axis: How our gut microbiota can help us understand neurological health and disease

Speakers

Jane Foster, Ph.D.  McMaster University, Hamilton, Ontario, Canada

Eran Blacher, Ph.D. , Stanford University, Stanford, CA

Winner of the Noster AAAS Microbiome prize 2021 

Details

https://www.sciencemag.org/custom-publishing/webinars/mapping-microbiota-gut-brain-axis-how-our-gut-microbiota-can-help-us

Overview 

It was not that long ago that the bacteria living on and inside us—our microbiota—was seen as a predominantly opportunistic collection of microbes that had simply found a convenient environmental niche in which to live. We understood that our gut microbes played a critical part in the digestive process, but what has come to light only more recently is just how deeply and broadly our health and wellness is enmeshed with those trillions of microbes we carry around with us. One area of particularly intensive study is the impact of metabolites released by the gut microbiota on neurological health and disease. An increasing body of evidence points to the importance of the gut–microbiota–brain axis in certain neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) as well as psychiatric disorders such as depression and anxiety. In this webinar, our experts will describe their research into the dynamic connection between the gut and the brain, sharing important new insights that have emerged from this burgeoning field of study. During the webinar, the speakers will:

Outline the fundamentals of the microbiota–gut–brain axis

Explain how gut bacteria can modulate neuroactive compounds that travel to the central nervous system and impact neural cell health

Describe potential therapeutic pathways in the microbiota–gut–brain axis that may be targeted in neurological and psychiatric disorders

Answer your questions live during the broadcast.

This webinar will last for approximately 60 minutes.

Jane Foster, Ph.D.

McMaster University, Hamilton, Ontario, Canada

Eran Blacher, Ph.D.

Stanford University, Stanford, CA

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News and Events

 2021 NOSTER & Science Microbiome Prize: Noster Inc and AAAS announce the winner and finalists of the 2021 NOSTER & Science Microbiome Prize

News release 

https://www.sciencemag.org/prize-winner-uncovers-link-between-microbiome-metabolites-and-neurodegeneration

The winner

Eran Blacher of the Department of Neurology at Stanford University, USA, is the recipient of the 2021 NOSTER & Science Microbiome Prize “for his work in exploring the relationship between the microorganisms that live inside us and neurodegenerative diseases such as Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS)”.

Winning essay

Can microbes combat neurodegeneration?

Science  09 Jul 2021: Vol. 373, Issue 6551, pp. 172-173 DOI: 10.1126/science.abi9353

https://science.sciencemag.org/content/373/6551/172?_ga=2.137923056.1143552100.1628602264-936586627.1628602264

Finalists 

Maria Zimmermann-Kogadeeva, Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg 69117, Germany.

Essay 

Quantifying host-microbiota interactions

Science  09 Jul 2021: Vol. 373, Issue 6551, pp. 173 DOI: 10.1126/science.abi9357

Erez Baruch, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center, Houston, TX 77030, USA, and Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.

Essay 

Microbiota modulation to fight cancer

Science  09 Jul 2021: Vol. 373, Issue 6551, pp. 173 DOI: 10.1126/science.abi9360

Further information

１．Winner and finalists of the 2021 NOSTER & Science Microbiome Prize including their essays and profiles.

https://www.sciencemag.org/prize-winner-uncovers-link-between-microbiome-metabolites-and-neurodegeneration

２．NOSTER & Science Microbiome Prize

https://www.sciencemag.org/prizes/noster-science-microbiome-prize

The NOSTER Science Microbiome Prize has been established to reward innovative research by young investigators working on the functional attributes of the microbiota of any organism that has potential to contribute to our understanding of human or veterinary health and disease or to guide therapeutic interventions.

https://www.sciencemag.org/prizes/noster-science-microbiome-prize?_ga=2.40011490.1143552100.1628602264-936586627.1628602264

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Credit: S. Yasuda et al., Elucidation of Gut Microbiota-Associated Lipids Using LC-MS/MS and 16S rRNA Sequence Analyses, iScience, 23, 101841, (2020). https://doi.org/10.1016/j.isci.2020.101841

Advanced non-targeted lipidomics to elucidate the complex lipid diversity of intestinal flora

Makoto Arita, a professor at Keio University and the Team Leader of the Laboratory for Metabolomics at RIKEN Center for Integrative Medical Sciences, and colleagues report on the comprehensive analysis of complex lipid metabolites produced by gut microorganisms. They developed new lipidomics technology by combining non-targeted mass spectrometry, which enables comprehensive analysis in an unbiased fashion, and feature-based molecular spectrum networking, which supports structural estimation of unknown molecules.

Employing a protocol consisting of mice treated with antibiotics, Professor Arita and his team successfully identified 985 lipid structures in feces of which approx. 24.8% appeared to be dependent on gut microbiota as judged by > 10-fold decrease in antibiotic-treated mice. Furthermore, they identified unique lipid structures directly related to gut microbiota including acyl alpha-hydroxyl fatty acid (AAHFA). Importantly, this research successfully predicted the bacterial species responsible for producing AAHFA and other unique lipids.

The results of this research are expected to contribute to the elucidation of complex lipid metabolism networks formed by the interaction between the gut microorganisms and hosts, and the discovery of new functional metabolites involved in host homeostasis and the onset of diseases.

Details of publications describing this research.

S. Yasuda et al., Elucidation of Gut Microbiota-Associated Lipids Using LC-MS/MS and 16S rRNA Sequence Analyses, iScience, 23, 101841, (2020).

https://doi.org/10.1016/j.isci.2020.101841

N. Okahashi et al., Global profiling of gut microbiota-associated lipid metabolites in antibiotic-treated mice by LC-MS/MS-based analyses, STAR Protocols, 2, 100492, (2021).

https://doi.org/10.1016/j.xpro.2021.100492

Further information

RIKEN Center for Integrative Medical Sciences

Laboratory for Metabolomics

Team Leader: Makoto Arita      

https://www.riken.jp/en/research/labs/ims/metabolom/index.html

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News and Events 

NOSTER SPONSORS LIVE AAAS SCIENCE WEBINAR on  13 January 2021 at 12:00 p.m. ET for 60 minutes

What our microbiomes can (and must) teach us about our health and disease

Speakers

Jeffrey I. Gordon, M.D. Washington University School of Medicine St. Louis, MO

Oliver Harrison, Ph.D. Benaroya Research Institute Seattle, WA

Details 

https://www.sciencemag.org/custom-publishing/webinars/what-our-microbiomes-can-and-must-teach-us-about-our-health-and-disease

Overview 

Human postnatal development is typically viewed from the perspective of our “human” organs. But perhaps we are missing part of the picture? The symbiotic relationships with the microorganisms that inhabit our gastrointestinal tract and skin can impact our healthy growth, resistance to disease, and response to infection. Evidence is accumulating that a shift in the normal development of the gut microbiome is causally related to childhood undernutrition, a devastating global health problem with long-term effects. Perturbing the microbiota may also impact the development and health of our immune system and its response to both colonization by commensal microbes and attack by pathogens. In this webinar, we’ll explore the increasingly appreciated role of the microbiome in human health and wellness. During the webinar, our expert speakers will:

Outline how a deepening understanding of the microbiome has advanced our appreciation of its role in human development and general health

Describe how research into links between the microbiome and childhood undernutrition can inform more effective clinical treatments

Explore how the immune response to the gut community impacts the body’s response to pathogenic microbes

Answer your questions during the live event.

This webinar will last for approximately 60 minutes.

Jeffrey I. Gordon, M.D.

Washington University School of Medicine St. Louis, MO

Oliver Harrison, Ph.D.

Benaroya Research Institute Seattle, WA

[nkhealth]

Welcome to the MRX Podcast. Insightful conversations with scientists actively pursuing research on the human microbiome.

Episode three

Mariana Byndloss: Finalist in the 2020 NOSTER & Science Microbiome Prize

Our guest today is Mariana Byndloss, an Assistant Professor of Pathology, Microbiology and Immunology at Vanderbilt University Medical Center, in Nashville, Tennessee.

Mariana was one of the two finalists in the 2020 first annual NOSTER & Science Microbiome Prize for her work on “Microbial management”.

  Mariana Byndloss  (left) in conversation with MRX Research website editor, Adarsh Sandhu during the recording of this episode of the MRX Podcast.

Links to the platforms hosting the Microbiome ResearchX Podcast

Apple Podcasts

https://podcasts.apple.com/podcast/id1541525939

Spotify

https://open.spotify.com/show/29ya9FbPaQJ6BI2ntaAYwi

Google Podcasts

https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5idXp6c3Byb3V0LmNvbS8xNTA0NzY1LnJzcw==

Related information

Mariana Byndloss

https://www.vumc.org/pmi/person/mariana-xavier-byndloss-dvm-phd 

NOSTER & Science Microbiome Prize 2021

https://www.sciencemag.org/prizes/noster-science-microbiome-prize

NOSTER Science Microbiome Prize Ceremony 2020

https://noster-mrx.net/

[nkhealth]

Welcome to the MRX Podcast. Insightful conversations with scientists actively pursuing research on the human microbiome.

Episode two

Chun-Jun Guo: Finalist in the 2020 NOSTER & Science Microbiome Prize

Our guest today is Chun-Jun Guo, an assistant professor at the Jill Roberts Institute for Research in Inflammatory Bowel Disease at Weill Cornell Medicine, New York.

Chun-Jun Guo (CJ) was one of the two finalists in the 2020 first annual NOSTER & Science Microbiome Prize for his work on “Modulating microbiome metabolites in vivo”.

Chun-Jun Guo (left) in conversation with MRX Research website editor, Adarsh Sandhu during the recording of this episode of the MRX Podcast.

Links to the platforms hosting the Microbiome ResearchX Podcast

Apple Podcasts

https://podcasts.apple.com/podcast/id1541525939

Spotify

https://open.spotify.com/show/29ya9FbPaQJ6BI2ntaAYwi

Google Podcasts

https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5idXp6c3Byb3V0LmNvbS8xNTA0NzY1LnJzcw==

Related information

Chun-Jun Guo

https://gradschool.weill.cornell.edu/faculty/chun-jun-guo

NOSTER & Science Microbiome Prize 2021

https://www.sciencemag.org/prizes/noster-science-microbiome-prize

NOSTER Science Microbiome Prize Ceremony 2020

https://noster-mrx.net/

[nkhealth]

Welcome to the MRX Podcast. Insightful conversations with scientists actively pursuing research on the human microbiome.

Episode one

Oliver Harrison: 2020 Grand Prize Winner of the NOSTER & Science Microbiome Prize

Our guest today is Oliver Harrison, the 2020 winner of the first annual NOSTER & Science Microbiome Prize for his work on “how skin microbes interact with the immune system to aid wound healing”.

Oliver is a Principal Investigator at the Benaroya Research Institute at Virginia Mason (BRI), Seattle.

Oliver Harrison (left) in conversation with MRX Research editor, Adarsh Sandhu during the recording of this episode of the MRX Podcast.

Links to the platforms hosting the Microbiome ResearchX Podcast

Apple Podcasts

https://podcasts.apple.com/podcast/id1541525939

Spotify

https://open.spotify.com/show/29ya9FbPaQJ6BI2ntaAYwi

Google Podcasts 

https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5idXp6c3Byb3V0LmNvbS8xNTA0NzY1LnJzcw==

Related information

Oliver Harrison

https://www.benaroyaresearch.org/what-is-bri/scientists-labs/scientists/oliver-harrison-phd

NOSTER & Science Microbiome Prize 2021

https://www.sciencemag.org/prizes/noster-science-microbiome-prize

NOSTER Science Microbiome Prize Ceremony 2020

https://noster-mrx.net/

[nkhealth]

NOSTER & Science Microbiome Prize 2021

Noster Inc and Science announce the opening of applications for the Noster & Science Microbiome Prize 2021

Eligibility

Entrants must be younger than thirty-five (35) years of age, must hold an M.D., PhD.or M.D./Ph.D at the time of entry, and have received their degree in the last 10 years.

The applicant must have done or directed all of the work and it must have been performed in the past three years.

Submission

The Prize will be judged on the basis of 1,000-word essay and supporting documents. The essay should describe the innovative research performed by the applicant that reveals exciting novel functions of the microbiota that has potential to contribute to our understanding of human or veterinary health and disease or to guide therapeutic interventions.

Winner and Finalists  for 2020

https://www.sciencemag.org/prize-winner-uncovers-microbes-role-tissue-repair

Details and related information

AAAS Science link to detailed instructions for applications 

https://www.sciencemag.org/prizes/noster-science-microbiome-prize

NOSTER Science Microbiome Prize Ceremony 2020

https://noster-mrx.net/post/628736391070810112/noster-science-microbiome-prize-ceremony-2020

Screen capture of the inaugural NOSTER Science Microbiome Prize Ceremony held on 3rd September 2020.

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NOSTER holds seminar at BioJapan 2020  

14 October 13 :30 to 14 :30 Pacifico Yokohama, Japan       

Creating innovative therapeutic agents by controlling the gut microbiome 

Speakers 

Prof. Jun Ogawa, Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University,

Prof. Reiko Shinkura, Laboratory of Immunology and Infection Control Institute for Quantitative Biosciences The University of Tokyo

Dr. Yasunori Yonejima, Research Manager, R&D Division Microbiome group, Noster Inc.

Abstract

Dysbiosis is frequently reported to be associated with illnesses such as inflammatory bowel disease (IBD), obesity, cancer, etc. Immunoglobulin A (IgA) is the antibody secreted into the intestinal lumen. IgA plays a critical role in the defense against pathogens and in the maintenance of intestinal homeostasis through gut microbial control. However, how secreted IgA regulates gut microbiota is not completely understood. Our main question is what kind of bacterial molecule an intestinal high-affinity IgA recognizes and targets. To address this question, we generated hybridomas from IgA producing cells in small intestine of wild type mice. As a candidate of efficient gut microbiota modulator, we selected a W27 IgA. W27 IgA selectively inhibited the in vitro growth of bound bacteria, including Escherichia coli (E. coli), suggesting that W27 IgA has an ability to improve the intestinal environment. Thus, W27 IgA oral treatment is a potential remedy for a variety of diseases associated with dysbiosis, acting through restoration of the host-microbial symbiosis. Moreover, the latest findings of gut microbial research such as intestinal bacterial metabolites (postbiotics) as an alternative state dual controller that simultaneously controls disease state and intestinal flora, and future drug discovery based on these new findings will be introduced.

Photographs of the event 

Prof. Jun Ogawa, Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University,

Prof. Reiko Shinkura, Laboratory of Immunology and Infection Control Institute for Quantitative Biosciences The University of Tokyo

Dr. Yasunori Yonejima, Research Manager, R&D Division Microbiome group, Noster Inc.

Kohey Kitao, Noster CEO (Left),  Reiko Shinkura ,  Jun Ogawa , and  Yasunori Yonejima. 

Further information

Noster Inc 

https://www.noster.inc/

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NOSTER Science Microbiome Prize Ceremony 2020

On-line prize giving ceremony for the NOSTER Science Microbiome Prize 2020 was held on 3rd September 2020.

The NOSTER Science Microbiome Prize was established in 2020 to reward innovative research by young investigators working on the functional attributes of the microbiota of any organism that has potential to contribute to our understanding of human or veterinary health and disease or to guide therapeutic interventions [1]. The winner and finalists of the Prize were announced in July 2020 [2].

The inaugural prize giving ceremony was opened by Bill Moran Publisher, Science Family of Journals, with an overview of the NOSTER Science Microbiome Prize and its role in promoting global partnerships in scientific research.

Next, Kohey Kitao, Noster CEO, gave a congratulatory speech thanking “Bill Moran, Roger Goncalves, Caroline Ash, Sean Sanders and all members of AAAS; Aska Corp., Japan; Professor Jeffrey Gordon; and the recipients of the awards for taking part in this on-line version of the ceremony that was originally scheduled to be held at the AAAS headquarters in Washington DC.” Mr Kitao added that the Prize was for the advancement of research on the microbiome for the benefit of all people, and he hoped that supporting young researchers will lead to therapeutic innovations.

Caroline Ash Senior Editor Science, introduced Jeffery Gordon, Dr. Robert J. Glaser Distinguished University Professor and Director of the Center for Genome Sciences and Systems Biology at Washington University in St. Louis, who gave an invited talk about his pioneering research on the gut microbiome and human health [3].

Following Professor Gordon’s talk Dr Ash gave an overview of the research activities of the recipients of this year’s Prize as well as the process of selecting the winner and two finalists [4]. This year’s winner, Oliver Harrison described his research that addressed the questions, “what extent do the conventional rules of adaptive immunity to pathogens apply to these noninvasive microbes? And, how do commensal-specific T cells sense and respond to environmental stresses during tissue injury?”

Next, this year’s finalists Mariana Xavier Byndloss and Chun-Jun Guo described their research that was described in their essays entitled, “Microbial management” and “Modulating microbiome metabolites in vivo”, respectively.

The ceremony continued with lively discussion on topics ranging from how the recipients wrote their essays; insights into publishing in Science by Holden Thorp, editor-in-chief of the Science family of journals; future challenges in microbiome research including the importance of therapeutics and drug discovery.

The organizers of the ceremony hope to arrange a face-to face meeting when travel restrictions due to the COVID-19 pandemic are lifted.

The meeting was chaired by Adarsh Sandhu.

References

[1] NOSTER & Science Microbiome Prize

https://www.sciencemag.org/prizes/noster-science-microbiome-prize

[2] Prize Winner Uncovers Microbes’ Role in Tissue Repair

https://www.sciencemag.org/prize-winner-uncovers-microbes-role-tissue-repair

[3] GORDON LAB

https://gordonlab.wustl.edu/

[4] 2020 Noster Prize Winners

https://www.sciencemag.org/prizes/noster/2020

Further information

About NOSTER

https://www.noster.inc/

Microbiome Research X

https://noster-mrx.net/

Website dedicated to sharing the latest advances in microbiome research that was launched by Noster in Spring 2020

Screen capture of the inaugural NOSTER Science Microbiome Prize Ceremony held on 3rd September 2020.