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Cholesterol Whey and LDL

The positive health benefits of whey protein concentrate do not end with its effects on immunity and cancer prevention and treatment. Whey protein concentrate was also found to be a potent inhibitor of low density oxidised lipoprotein cholesterol. Current research suggests that LDL conversion to oxidised LDL is the trigger that leads to atherogenesis... Plaque formation and lesions associated with atherosclerosis. Any substance that prevents oxidation of LDL is therefore thought to be anti-atherogenic. Although animal-based proteins have traditionally been involved as pro-atherogenic, whey proteins appear to be an exception to the rule. Wey protein consists of several minor and major fractions, such as beta-lactoglobulin, alpha-lactalbumin, albumin, lactoferrin and immunoglobulin. The minor constituent responsible for the ability of whey protein concentrate to prevent oxidation of LDL appears to be the lactoferrin fraction of the protein. 3. In Whey, Lactoferrin When lactoferrin was removed from the protein, the ability of whey protein concentrate to prevent LDL oxidation was significantly reduced, leading researchers to speculate, "Our results suggest that LF (lactoferrin) is the main factor responsible for the inhibitory effect of whey protein (LDL) and may function synergistically with other whey protein factors, such as whey protein. Another study using rats examined the effects of whey protein concentrate and casein on cholesterol and risk factors for heart disease. Although casein (another milk-based protein commonly used in research) is known to increase cholesterol in humans and animals, whey protein has the opposite effect, leading researchers to note, "At the high dietary protein level [300 gramme per kilogramme of feed] , whey protein significantly lowered plasma and liver cholesterol and also plasma triacylglycerols." 4. The cholesterol-lowering effects of whey protein concentrate in this study were also associated with a reduction in LDL cholesterol. Most interesting was the fact that this effect on cholesterol was not seen when the animals were fed amino acid mixtures that simulated whey protein, so it is clear that there are properties within the whey that have these effects beyond the amino acid profile of the animal. Way and Bone Growth Finally, protein whey appears to play a direct role in bone growth. Researchers found that rats fed whey protein concentrate had increased bone strength and bone protein, such as collagen. This discovery led research to test whether or not the whey protein directly stimulated osteoblast (bone cell) growth in vitro. Whey proteins have been shown to stimulate, dose-dependent, total protein synthesis, DNA content, and increased bone cell hydroxyproline content. 5. It should be noted that not all protein concentrates are equal. The manufacturer takes special care to process whey proteins to remove lactose and fats without losing their biological activity. The protein must be processed under low temperature and low acidic conditions so as not to "denature" the protein. Maintaining the natural state of the protein is essential for the biological activity of the protein. These research findings, combined with the previous decade of the whey protein study, should convince anyone that whey protein concentrate is truly a life-long protein. Check more details at http://www.nutrioxdistribution.com

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Whey Protein Importance

In previous issues, extensive research has shown the many potential health benefits of whey protein concentrate. The majority of this research was conducted in the 1980s and early 1990s, and was extremely persuasive. Scientists continued their research on whey proteins with even more impressive results. What follows is some of the more recent, interesting and useful research on whey proteins. Wey and Cancer Additional animal studies on cancer-causing chemicals have been done to see what effects whey protein concentrate would have on cancer prevention or treatment. Scientists fed different proteins to rats and then subjected them to potent carcinogen dimethylhydrazine. As with previous research, rats fed whey protein concentrate showed fewer tumours and reduced pooled tumour area (tumour mass index). Researchers found that whey protein offered "considerable protection to the host" over other proteins, including soya. 1. Even more exciting, in vivo cancer and whey research has shown that whey protein concentrate inhibited the growth of breast cancer cells at low concentrations (Baruchel S. and Vaiu G., Anti Cancer Research, 1996). Finally, and most importantly, a fairly recent clinical study with cancer patients showed a regression of 30 grammes of whey protein concentrate in some patients' tumours. 2. Well, Whey and Glutathione This new research using whey protein concentrate has led researchers to an amazing discovery of the relationship between cancer cells, glutathione (GSH) and whey protein concentrate. It was found that whey protein concentrate selectively depletes the cancer cells of their glutathione, making them more susceptible to cancer treatments such as radiation and chemotherapy. Cancer cells and normal cells have been found to respond differently to nutrients and drugs that affect the status of glutathione. What is most interesting to note is that the concentration of glutathione in tumour cells is higher than that of the normal cells that surround it. This difference in glutathione status between normal cells and cancer cells is believed to be an important factor in the resistance of cancer cells to chemotherapy.As the researchers put it, 'Tumor cell GSH concentration may be among the determinants of cytotoxicity [cell poisoning] of many chemotherapy agents and radiation, and an increase in GSH concentration appears to be at least one of the mechanisms of drug resistance to chemotherapy acquired.' They further state, "It is well-known that rapid GSH synthesis in tumour cells is associated with high rates of cellular proliferation. Depletion of tumour GSH in vivo decreases the rate of cellular proliferation and inhibits cancer growth." The problem is that it is difficult to reduce glutathione sufficiently in tumour cells without putting healthy tissue at risk and putting the cancer patient in a worse condition. What is needed is a compound that can selectively deplete the cancer cells of its glutathione while increasing or at least maintaining levels of glutathione in healthy cells. This is exactly what the protein seems to be doing. In this new research it was found that cancer cells undergoing whey proteins had lost their glutathione and inhibited growth, while normal cells had increased GSH and increased cell growth. These effects have not been seen with other proteins. Not surprisingly, the researchers concluded, "Selective depletion of tumour GSH may in fact render cancer cells more vulnerable to the action of chemotherapy and eventually protect normal tissue against the deleterious effects of chemotherapy." The exact mechanism by which whey protein achieves this is not fully understood, but it appears to interfere with the normal feedback mechanism and re-emerge. It is known that the production of glutathione is negatively inhibited by its own synthesis. Since the baseline level of glutathione in cancer cells is higher than that of normal cells, it is probably easier to achieve negative-feedback inhibition in cancer cells with glutathione than in normal cells with glutathione. Check more details at http://www.nutrioxdistribution.com