sayakxmi

[sayakxmi]

im so charmed by characters who are likely to have the worst day of their life at any given time in the story where we happen to check in on them

[sayakxmi]

I have no outline tho, just vibes

[sayakxmi]

The above is a video shared by smrchildsadness on Twitter, showing a person participating in a pride parade exchanging a pride flag with a person standing on his (am using his pronoun based on the TikToks/Tweets of what happened) doorway who had a Portuguese flag. There are sounds of cheers and crying and the two people hug each other as they exchange the flags. The man at the doorway then waved kisses to the crowd within the pride parade.

The Tweet says: "NO YOU DONT UNDERSTAND HE WAS WAVING THE PORTUGUESE FLAG BECAUSE HE DIDN'T HAVE A PRIDE FLAG AND THEY TRADED FLAGS AND HE'S SO EMOTIONAL TO GET HIS OWN PRIDE FLAG I'M EMOTIONALLY RUINED"

For context, apparently they were worried that maybe he's a nationalist because he was waving the Portuguese flag and some nationalists opposing the pride march were waving that flag. But upon interacting with him, it turns out he didn't have have a pride flag and he wanted to wave *a* flag in support of the pride march. So they had an exchange and now he has his own pride flag 😭🥹.

The image above is a Tweet by kunwara_ladkaa that says "I'm crying so much right now (Image taken by Manuel Fernando Araújo/Lusa)". The image shows the same man from the pride parade crying as he hugs his new pride flag.

The above image is a Tweet by dudz_zZzz that says "ainda não parei de pensar nele," which according to Google translate from Portuguese to English is "I still haven't stopped thinking about him." The image is a drawing of the person from the pride parade, crying as he hugs his new pride flag.

Posts were made on July 1, 2024.

[sayakxmi]

Fuck it I'm opening commissions

I've been scared to do this but I'm throwing caution to the wind

Behold: a commission sheet I made like a year ago

I take payment through paypal or kofi

Message me here or on discord, my username there is foxlorre

Okie bye :3

[sayakxmi]

I'm keeping an eye out for heat stroke in my area and I can't figure out what a full body flush would look like on dark skin since all the pictures are just fake training pictures. Anyone have video/pics of a heat stroke flush on black skin?

[sayakxmi]

I really love Yuuchi I hope to see him in VR !!

[sayakxmi]

Deep Blue is 30 years old and was capable of defeating chess grand champions. It could be housed in a single cabinet.

ChatGPT spans untold data centers devouring massive amounts of electricity and it got its ass whipped by an 8 bit gaming console from the 1970s.

[sayakxmi]

"ohhh i just don't understand how people can be racist it makes no sense!!! transphobia is just so strange and foreign to me i can't possibly understand why it happens!!" that's not something you should be proud of. it's really not that hard to understand the underlying motivations of bigotry. it is not noble or virtuous to act like bigotry is some mystical evil that none of us Good People™ can possibly fathom. your ignorance is not a sign of moral purity, it's just plain old dangerous ignorance.

[sayakxmi]

"A cure for HIV could be a step closer after researchers found a new way to force the virus out of hiding inside human cells.

The virus’s ability to conceal itself inside certain white blood cells has been one of the main challenges for scientists looking for a cure. It means there is a reservoir of the HIV in the body, capable of reactivation, that neither the immune system nor drugs can tackle.

Now researchers from the Peter Doherty Institute for Infection and Immunity in Melbourne, have demonstrated a way to make the virus visible, paving the way to fully clear it from the body.

It is based on mRNA technology, which came to prominence during the Covid-19 pandemic when it was used in vaccines made by Moderna and Pfizer/BioNTech.

In a paper published in Nature Communications, the researchers have shown for the first time that mRNA can be delivered into the cells where HIV is hiding, by encasing it in a tiny, specially formulated fat bubble. The mRNA then instructs the cells to reveal the virus.

Globally, there are almost 40 million people living with HIV, who must take medication for the rest of their lives in order to suppress the virus and ensure they do not develop symptoms or transmit it. For many it remains deadly, with UNAids figures suggesting one person died of HIV every minute in 2023.

It was “previously thought impossible” to deliver mRNA to the type of white blood cell that is home to HIV, said Dr Paula Cevaal, research fellow at the Doherty Institute and co-first author of the study, because those cells did not take up the fat bubbles, or lipid nanoparticles (LNPs), used to carry it.

The team have developed a new type of LNP that those cells will accept, known as LNP X. She said: “Our hope is that this new nanoparticle design could be a new pathway to an HIV cure.”

When a colleague first presented test results at the lab’s weekly meeting, Cevaal said, they seemed too good to be true.

“We sent her back into the lab to repeat it, and she came back the next week with results that were equally good. So we had to believe it. And of course, since then, we’ve repeated it many, many, many more times.

“We were overwhelmed by how [much of a] night and day difference it was – from not working before, and then all of a sudden it was working. And all of us were just sitting gasping like, ‘wow’.”

Further research will be needed to determine whether revealing the virus is enough to allow the body’s immune system to deal with it, or whether the technology will need to be combined with other therapies to eliminate HIV from the body.

The study is laboratory based and was carried out in cells donated by HIV patients. The path to using the technology as part of a cure for patients is long, and would require successful tests in animals followed by safety trials in humans, likely to take years, before efficacy trials could even begin.

“In the field of biomedicine, many things eventually don’t make it into the clinic – that is the unfortunate truth; I don’t want to paint a prettier picture than what is the reality,” stressed Cevaal. “But in terms of specifically the field of HIV cure, we have never seen anything close to as good as what we are seeing, in terms of how well we are able to reveal this virus.

“So from that point of view, we’re very hopeful that we are also able to see this type of response in an animal, and that we could eventually do this in humans.”

Dr Michael Roche of the University of Melbourne and co-senior author of the research, said the discovery could have broader implications beyond HIV, with the relevant white blood cells also involved in other diseases including cancers.

Dr Jonathan Stoye, a retrovirologist and emeritus scientist at the Francis Crick Institute, who was not involved in the study, said the approach taken by the Melbourne team appeared be a major advance on existing strategies to force the virus out of hiding, but further studies would be needed to determine how best to kill it after that.

He added: “Ultimately, one big unknown remains. Do you need to eliminate the entire reservoir for success or just the major part? If just 10% of the latent reservoir survives will that be sufficient to seed new infection? Only time will tell.

“However, that does not detract from the significance of the current study, which represents a major potential advance in delivery of mRNA for therapeutic purposes to blood cells.”"

-via The Guardian, June 5, 2025

[sayakxmi]

i feel like xy would only improve if they had given clemont the roller skates at some point

[sayakxmi]

it is so funny to me how i started learning english on my own age 10 because the manga i was reading was turning so so so bad i went to fan content to cope with how shit it was. and 15 years later this pays off as my boss tells me i'm an essential asset in the team as the only fluent english-speaker.

[sayakxmi]

current fan creation landscape is kinda like if you went to a party with a homemade cake and everyone takes a slice and silently thumbs up at you with no attempt to start a conversation except for occasionally some guy sits in the corner with a tape recorder critiquing the cake as though he was a restaurant critic and another guy is handing the cake to an uber driver like "yeah i need you to find a restaurant that makes cake like this so i can have more of it" and the only person that's talked to you in 30 minutes is a very sweet little guy who was like "hey i liked your cake" and then ran away apologizing for bothering you the moment you said thank you.

[sayakxmi]

“We’re in a fanfic drought” Tell the writers you like their work.

“All Tumblr ever does is write oneshots now” Tell the writers that you’d love to see them write longer things.

“Nobody updates their fics anymore” Tell the writers you love the fic and want to see more of it.

Tell the writers.

[sayakxmi]

Reblog to give a trans person a fresh and perfectly ripe mango wait huh

It's the wikipedia image??? How big could it be

What

Huh???

[sayakxmi]

idk i just like how they wear their bags differently??? tsurugi tries hard 2 b cool and tenma???

[sayakxmi]

Was drawing pairings I had never drawn before

[sayakxmi]

Eventually I will draw every ship in here