scfeextraction

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Supercritical CO2 Extraction of Cannabinol from Hemp and Its Antibacterial Activity

Supercritical CO2 extraction of cannabinol from hemp was established, and the antimicrobial properties of the extracts were investigated. Through the analysis of single factor and orthogonal test, the optimum extraction process of three cannabinoids from hemp by supercritical CO2 was determined: extraction temperature 45 C, extraction time 70 min, entrainer dosage 300 m L, extraction times 3 times. The bacteriostasis tests of E. coli and Staphylococcus aureus with MIC of 8 mg/ml and 6 mg/ml were carried out by filter paper method. Under these conditions, cannabinol (CBD) was 3.189 mg/g, hexahydrocannabinol (CBN) was 2.206 mg/g, tetrahydrocannabinol (9-THC) was 58.757 mg/g, that is, the three cannabinoids were 64.152 mg/g. The diameter of bacteriostasis circle of Escherichia coli and Staphylococcus aureus were 15.4 mm and 25.8 mm, respectively. The supercritical extract had certain bacteriostasis.

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Application of Large Supercritical Extraction Equipment in Natural Product Development

Supercritical fluid extraction (SFE) is one of the most advanced separation and extraction technologies in the world. In recent decades, it has attracted great interest of researchers all over the world. Through the efforts of researchers, it has made considerable progress. In the fields of medicine, chemical industry, food, petroleum, environmental protection and cosmetics, a number of valuable topics have been completed, and a new industry has been formed worldwide. Developing and utilizing supercritical fluid extraction (SFE) technology to realize large-scale industrial production is a major breakthrough in transforming dozens or hundreds of scientific research achievements that have been developed in the laboratory into productivity and economic benefits.

Supercritical fluids have special solubility, which was discovered by Americans at the end of the 19th century. It was not until the 1970s that Germany was applied to beer processing to extract beer and other industrial applications. In the 1980s, China and Japan started at the same time, and now Japan's industrial application has led the world level. Since China started in the 1980s, many scientific research institutes have made great efforts to explore and practice, and have achieved a lot. For example: capsicum red pigment, Angelica oil, garlic oil, shikonin red pigment, pepper oil, lecithin and so on, not less than several hundred kinds, but mostly in the laboratory results. At present, there are several domestic supercritical equipment manufacturers (from 1 to 200 liters), which can only meet the laboratory and some more expensive products extraction, but from the current domestic research results and needs, far from meeting the needs of large-scale industrial production.

Why China should industrialize in the field of supercritical fluid extraction

China is a country rich in natural resources of animals and plants. Many natural resources, such as natural pigments, fragrances and cosmetics, are among the most valuable resources for human survival and prosperity. Because of the backward deep processing technology in our country, especially in some economically underdeveloped areas, many valuable natural resources are wasted in vain or exported cheaply as raw materials. After deep processing by foreign countries, they are sold back to China at a high price, such as beer industry, tea industry, pigments and flavors, etc. Large-scale supercritical extraction equipment is urgently needed for the comprehensive utilization of various wastes such as peel and stone, the Westernization of herbal medicine and the integration of international herbal medicine market. It will turn the cheap natural resources in poor areas into high value-added green products.

Obstacles to industrialization

At present, because the processing technology of domestic large-scale extraction kettle is difficult, the volume of the supercritical extraction equipment is small, and the extraction of some light-weight substances has the disadvantages of high cost, high cost and low processing capacity. From the research results, domestic equipment can not meet the industrial production needs of many industries, while domestic needs large-scale industrial extraction equipment. Enterprises should have more than one hundred. The introduction of such large-scale equipment is very expensive. This hinders the wide application of supercritical extraction technology in China. At the same time, the standardization of equipment and the safety of supporting equipment are urgent issues to be solved. After three years of hard work, we have successfully developed a large supercritical extraction equipment from 100L to 5000L, which can meet the technical requirements of extraction at pressure, temperature and flow rate. The cost of this equipment is only 30% of that of imported equipment. It has reasonable structure, superior performance and meets the hygienic conditions of the food industry. At the same time, it is superior to similar equipment at home and abroad in temperature sensing, anti-fatigue dynamic strength, sealing performance, safety factor and other technical indicators. After more than two years of testing, the equipment runs well. The products are: Angelica oil, Radix Angelicae oil, shikonin red pigment, frog seed oil of Changbai Mountain, sea rainbow oil, ginseng oil, Schisandra oil, safflower oil, hop oil, garlic oil, ginger oil, aloin, pyrethrum and other dozens of varieties, but also can remove 80% of pesticide residues from ginseng powder.

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What’s the CO2 supercritical fluid extraction device

Supercritical fluid extraction (SFE) is a strong green separation technique. Supercritical CO2 extraction uses CO 2 as a solvent. Supercritical CO 2 fluid has a large density and dielectric constant, and the solubility of the material is large. Pressure and temperature Therefore, the change rapidly changes, not only the solubility of certain substances is selective, but also the separation of solvents and extracts.Compared with the conventional separation method, it has the characteristics of low extraction temperature, high selectivity, high efficiency, low energy consumption and no pollution. It is especially suitable for the extraction of fat-soluble, high-boiling, heat-sensitive substances, and can also be used for the fineness of different components. Separation. Widely used in the pharmaceutical, food industry, health care products, cosmetics, perfumes and other industries.

Small trials, comprehensive testing of the design and manufacture of supercritical extraction equipment, we have accumulated a great deal of experience in research and products for about ten years. Various supercritical extraction device models have become stereotyped system products with reasonable structure, safe and reliable, and easy to load and unload materials. The optimized design of sealing structure and special sealing material is more reliable and durable; double safety protection system design; measurement by CO2 cycle; temperature, flow and pressure process parameters are controlled by digital display, easy to operate and high degree of automation. The products of the supercritical extraction unit are designed for remote control and comply with (GMP) standards.Characteristics of supercritical CO2 extraction unit

• Low critical temperature for extraction and purification of heat sensitive compounds.

• Provides an inert environment to avoid product oxidation and effective extract content.

• Fast extraction, non-toxic, non-flammable, safe to use, no pollution to the environment.

• No solvent residue, no nitrates and heavy metal ions.

• The pressure ring for the extraction kettle can be opened quickly; the O-ring is imported for a period of more than 4 months.

• CO2 can be used for cycling.

• Can be designed and manufactured in accordance with (GMP) standards.

• The pressure stabilization system of the extraction kettle uses an inlet back pressure valve.

• Controlled by a computerized automatic control system (temperature, pressure, flow).

• All valves of the equipment are specially heat treated for durability.

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What’s the Working Process of Extraction

Working process of extraction: a) The liquid CO2 in the CO2 storage tank C302 is sucked and pressurized by the pressurizing pump, and into the extraction heater E402 for preheating when reaches the supercritical pressure, and then into the extractor along the pipeline. At this moment, the CO2 is in a supercritical state and has strong dissolved ability; b) After the extraction pressure reaches the set pressure, the extraction regulator valve K01, the separator S201 regulator valve K02, and the separator S202 regulator valve K03 are all switched into the “automatic” operating mode. The CO2 that dissolves the active ingredients of the material depressurize passes through K01 into the heater E403; c) In the separator 1 heater E403, CO2 continues to be heated, and then into separator S201; d) In the separator S201, CO2 is heated and maintained by the hot water in its jacket. Due to factors such as pressure reduction, the dissolution rate of the active ingredient of the material is reduced. In S201, material is partially separated and precipitated in S201 bottom; e) The dissolved CO2 of the active ingredient continues to depressurize through the KO2 into the separator 2 heater E404, heat insulation, and then into the separator S202; f) In the separator S202, due to factors such as pressure reduction, the dissolution rate of the active ingredient of the material is further reduced and is further separated and precipitated on the bottom of separator S202. At this time, the active ingredient of the material is basically separated, and the pure CO2 pass through the KO3 into the condenser E401 due to the pressure difference; g) In the condenser E401, CO2 is cooled to a liquid state, into the CO2 storage tank C302 following the pipeline; h) In the CO2 storage tank C302, the hydraulic CO2 is cooled by the chilled water in the internal coil, and the liquid CO2 into the pressure pump along the pipe and into the next extraction process.

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Company: Tradematt (Henan) Industry Co., Ltd. Email: SCFE@cntradematt.com Web: https://www.scfeextraction.com/ Name: Anna Ma

[scfeextraction]

What’s the Supercritical Fluid Extraction (SFE) Systems

Tradematt Supercritical Fluid Extraction (SFE) Systems extract chemical compounds using supercritical carbon dioxide instead of an organic solvent. The supercritical fluid state occurs when a fluid is above its critical temperature (Tc) and critical pressure (Pc), when it is between the typical gas and liquid state. Manipulating the temperature and pressure of the fluid can solubilize the material of interest and selectively extract it. The sample is placed in an extraction vessel and pressurized with CO2 to dissolve the sample. Transferred to a fraction collector, the contents are depressurized and the CO2 loses its solvating power causing the desired material to precipitate. The condensed CO2 can be recycled.

SFE applications in the food, pharmaceutical, and fine chemical industries:

Decaffeinating of coffee and tea

Extraction of essential oils (vegetable and fish oils)

Extraction of flavors from natural resources (nutraceuticals)

Extraction of ingredients from spices and red peppers

Extraction of fat from food products

Fractionation of polymeric materials

Extraction from natural products

Photo–resist cleaning

Precision part cleaning

Tags: co2 extraction machine canada,supercritical fluid extraction provider,supercritical co2 extraction company,best cbd extractor, supercritical fluid extraction

Company: Tradematt (Henan) Industry Co., Ltd.

Email: SCFE@cntradematt.com

Web: https://www.scfeextraction.com/

Name: Anna Ma

[scfeextraction]

What's the supercritical fuild CO2 extraction equipment advantages?

Supercritical fuild CO2 extraction equipment advantages

The SCFE extracts are regarded as very high quality as there are no chemical changes due to reactions or thermal degradation as the extractions are carried out using moderate processing temperatures.

- SCFE process is becoming increasingly popular due to its inherent potential for high recoverability and selectivity, fractionating superior-grade natural extracts from a variety of biomaterials.

- SCFE Process is an environmentally friendly process for industrial production. It meets safety regulations and legal restrictions as well as the increasing demand for the use of natural products.

- The Carbon Dioxide used in the SCFE process is non-toxic, odorless, tasteless, neutral, nonflammable and fully accepted as food grade solvent with GRAS status.

- High purity and tailor made specifications of the product due to easy manipulation and selectivity of separation.

- A wide spectrum of physical properties can be obtained in a single solvent by small variation of process parameters such as pressure and temperature.

- The SCFE extracts are known for accuracy, precision, specificity and linearity.

- Improved product consistency because of accurate controlled process parameters.

SCFE is the Technique of Choice for Many Important Nutraceuticals, Essential Oils and Spice Extracts

SCFE Process Ideal for

- Extraction of natural spices: Black Pepper, Celery Seed, Cumin, Cinnamon, Clove Bud, Nutmeg etc;

-Extraction of Natural Colors: Pigments from Paprika, etc;

- Extraction of actives from botanicals: Dry Ginger, Saw Palmetto, Rosemary etc;

- Extraction of Nutraceuticals, Cosmeceuticals:Forskolin, Turmerones - from Turmeric,Oscimum sanctum, Neem Leaf

-Extraction of cholesterol and other lipids from dried egg yolk;

-Extraction of Hops for the beverage industry;

- Biochemical components: Precipitation of Human Immunoglobulin G (IgG),Inactivation of viruses etc.

Sustainability has also become a leading strategy for new successful product and process development for the 21st century. Therefore new industrial processes which offer ecological and social advantages are demanded. New processes using Supercritical fluids, which improve current ones in simplicity, energy saving, recycling and in quality of obtained products, constitute clean processes in the frame of environmentally accepted technologies. Supercritical Fluid Extraction is becoming increasingly important as an environmentally acceptable replacement for more traditional solvents in the move towards Green Chemistry.

Company: Tradematt (Henan) Industry Co., Ltd.

Email: SCFE@cntradematt.com

Web: www.scfeextraction.com

Name: Anna Ma

[scfeextraction]

Industrial application of supercritical fluid extraction process

Industrial application of supercritical fluid extraction process

The special properties of supercritical fluids bring certain advantages to chemical separation processes. Several applications have been fully developed and commercialized.

Nutraceuticals

The Nutraceutical market is still a nascent market with potential for revenue in the coming years. In particular, the most interesting areas of Nutraceutical products are pointed in the products with effect in the immunological system, cancer risk, cardiovascular illness and elevated levels of cholesterol in the blood. SCFE provides interesting alternatives for development of Nutraceuticals. Its capacity can be considered as a strategic property. With SCFE technology it is feasible to remove solvent traces, aromas, flavors, fats etc.

Pharmaceuticals and Chemicals

Pharmaceutical industries as well as chemical industries are changing some of these traditional practices to accomplish fresh green goals. Thus extraction with carbon dioxide under supercritical conditions constitutes an emerging technology in terms of environmental impact.

Food and Flavoring- Extraction of natural spices

A very successful application of supercritical fluid extraction technique is the distillation of natural spices. Supercritical fluid extraction has the ability of high dissolution, high extraction yield and is efficient. CO2 is used as the extraction agent, the products are non toxic, leaves no residues, their color and fragrance are excellent. - Essential oils obtained from plant matrix form the basis of many pharmaceutical compounds in use nowadays and are the raw materials of flavors and fragrances. However, the traditional methods for extraction, such as hydro distillation, steam distillation, solvent extraction, and simultaneous distillation extraction are time consuming, labor intensive, and may violate new stringent environmental regulations. Thus supercritical fluid extraction is a viable alternative for many applications including essential oils extraction from herbs.

Natural products, especially essential oils that are aromatic liquids separated from herbal plants, represent the main raw materials for flavor, fragrances and pharmaceuticals. Flavoring and fragrance ingredients are the most numerous single group of international additives used by the food and personal care industries. Their market growth rate is increasing with time on an international level. The WHO regulations are changing to be strict, to safeguard the human health and a survey has been issued indicating that about 70-80% of the world populations rely on nonconventional medicine mainly of herbal sources in their primary health care. In time, traditional separation techniques such as hydro distillation, steam distillation, solvent extraction, and simultaneous distillation extraction need to be substituted by sustainable and green separation techniques.

Company: Tradematt (Henan) Industry Co., Ltd.

Email: SCFE@cntradematt.com

Web: www.scfeextraction.com

Name: Anna Ma

[scfeextraction]

Supercritical fluid extraction process: unique and innovative extraction process

The increased public awareness of the health, environment and safety concerns associated with the use of some organic solvents in food processing and the possible solvent contamination of the final products. The high cost of organic solvents and the increasingly stringent environmental regulations together with the new requirements of the medical and food industries for ultra-pure and high added value products have pointed out the need for the development of new and clean technologies for the processing of food ingredients.

Supercritical fluid extraction, using carbon dioxide as a solvent, has provided an excellent alternative to the use of chemical solvents. Over the past three decades, supercritical CO2 has been used for the extraction and isolation of valuable compounds. It is non-toxic, leaves no residues, and is considered a green manufacturing process.

Supercritical fluid extraction process: unique and innovative extraction process

Supercritical fluid extraction (SCFE) process has emerged as the alternative to the traditional solvent extraction process. It is a separation technique, which is developed by use of the fluid that has the ability of dissolution at supercritical pressure and supercritical temperature.

The extraction is carried out in highpressure equipment in batch or continuous manner, the supercritical solvent is put in contact with the material from which a desirable product is to be separated. The supercritical solvent, now saturated with the extracted product, is expanded to atmospheric conditions and the solubilized product is recovered in the separation vessel permitting the recycle of the supercritical solvent for further use (Figure 1).

As the extractions are carried out at high pressures, the extraction unit is fully automated, computerized, and highly sophisticate. Communication interfaces and input/output modules match the most challenging requirements in industrial automation thereby creating high degree of consistency and reproducibility between batches/lots.

Company: Tradematt (Henan) Industry Co., Ltd.

Email: SCFE@cntradematt.com

Web: www.scfeextraction.com

Name: Anna Ma

[scfeextraction]

hemp extraction process