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Which antipsychotics come in long-acting injectable form?

aripiprazole / aripiprazole lauroxil

fluphenazine

haloperidol

olanzapine

paliperidone

risperidone

* if switching from short-acting, try to use the same agent 

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12yoF can’t play sports anymore bc pain in legs. Exam shows pulsatile vessels within intercostal spaces & diminished femoral pulses relative to brachial pulses. M/L associated Dx?

Lower-extremity claudication (cramping w. exercise) w. signs of upper-body htn later in adolescence – this is coarctation of the aorta with moderate stenosis

Occurs in up to 10% of pts with Turner syndrome (45, XO)

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Mucopolysaccharidoses

= lysosomal storage disorders resulting from defective metabolism of glycosaminoglycans (GAGs), or long unbranched polysaccharides that comprise extracellular matrix of connective tissue

Severe intellectual disability, corneal clouding, coarse facial features, hepatosplenomegaly --> Hurler Syndrome (Type 1 MPS)

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Cirrhosis

In response to chronic injury, stellate (Ito) cells are activated into myofibroblasts capable of proliferating, promoting chemotaxis, & producing collagen in large quantities --> scar formation

Trichrome (collagen) stain shows blue areas of fibrosis

In quiescent phase, stellate cells store vitamin A