#11.43

[mtg-cards-hourly]

Back to Basics

"A ruler wears a crown while the rest of us wear hats, but which would you rather have when it's raining?" —Barrin, *Principia*

Artist: Andrew Robinson TCG Player Link Scryfall Link EDHREC Link

[catominor]

a very vulgar martial monday to you!

[btsvtarchive]

Mingyu talking about the 3d challenge and how wonwoo filmed both 3d & seven and jungkook edited them

[aliceemonth]

11.43 mag Pyx

08.03.2021

Nazlı ve Bora yıldızı.

♠️💚

[astrometrych]

Astronomy #Space #Espace #Astrometry

[peabah]

Erika Vogt

"Image Blocker 4"

2023

Acrylic, linen, paper, thread, marker

31 1/4 x 24 x 4 1/2 in / 79.37 x 60.96 x 11.43 cm

[covidsafehotties]

Published Jan 11, 2024

Abstract

Background

The striking increase in COVID-19 severity in older adults provides a clear example of immunesenescence, the age-related remodelling of the immune system. To better characterise the association between convalescent immunesenescence and acute disease severity, we determined the immune phenotype of COVID-19 survivors and non-infected controls.

Results

We performed detailed immune phenotyping of peripheral blood mononuclear cells isolated from 103 COVID-19 survivors 3–5 months post recovery who were classified as having had severe (n = 56; age 53.12 ± 11.30 years), moderate (n = 32; age 52.28 ± 11.43 years) or mild (n = 15; age 49.67 ± 7.30 years) disease and compared with age and sex-matched healthy adults (n = 59; age 50.49 ± 10.68 years). We assessed a broad range of immune cell phenotypes to generate a composite score, IMM-AGE, to determine the degree of immune senescence. We found increased immunesenescence features in severe COVID-19 survivors compared to controls including: a reduced frequency and number of naïve CD4 and CD8 T cells (p < 0.0001); increased frequency of EMRA CD4 (p < 0.003) and CD8 T cells (p < 0.001); a higher frequency (p < 0.0001) and absolute numbers (p < 0.001) of CD28−ve CD57+ve senescent CD4 and CD8 T cells; higher frequency (p < 0.003) and absolute numbers (p < 0.02) of PD-1 expressing exhausted CD8 T cells; a two-fold increase in Th17 polarisation (p < 0.0001); higher frequency of memory B cells (p < 0.001) and increased frequency (p < 0.0001) and numbers (p < 0.001) of CD57+ve senescent NK cells. As a result, the IMM-AGE score was significantly higher in severe COVID-19 survivors than in controls (p < 0.001). Few differences were seen for those with moderate disease and none for mild disease. Regression analysis revealed the only pre-existing variable influencing the IMM-AGE score was South Asian ethnicity (= 0.174, p = 0.043), with a major influence being disease severity (= 0.188, p = 0.01).

Conclusions

Our analyses reveal a state of enhanced immune ageing in survivors of severe COVID-19 and suggest this could be related to SARS-Cov-2 infection. Our data support the rationale for trials of anti-immune ageing interventions for improving clinical outcomes in these patients with severe disease.

[hypnoneghoul]

@herbal-quintessence

@ominousposting sent me a better picture of cos' 2017 pedal set up so HERE WE GO with what I can see and recognise

Voodoo Lab Mondo Pedal Power

Diamond Memory Lane 2

Diamond CPR1 Compressor

DigiTech Whammy

(90% sure) Boss NS-1X Noise Suppressor

Line 6 DL4 Delay Modeler

(could be) Boss DS-1 Distortion

I know it's not even half of it but I don't think I can get anything more, especially now (it's 11.43 pm💀) but summarizing, cos is a pedal princess

[btsvtarchive]

Mingyu talking about the 3d challenge and how wonwoo filmed both 3d & seven and jungkook edited them

[t-counter]

Do T’s have to be part of a word or can I just spam em?

is T T T one word or three words? (or no words?)

is TTT one word or three words? (or no words?)

T Count: 12

Letter Count: 105

Your T Percentage: 11.43%

Average T Percentage: 9.45%

You used the letter T 1.21 times as much as average!

—

I count letters, rather than words, so the amount of spaces in words has no bearing on your letter count.

Minimal t spam is alright, but I'm sure people can be more creative than just spamming a paragraph of 't's

[robbieroberu]

OMFGOOOOOOOOOOD IM GOING TO RIP SOMEONE'S FUCKING BALLS I JUST REALIZED THAT MY EXAM IS NOT FUCKING TOMORROW AND I COULD HAVE SPENT MY WHOLE DAY STUDYING MATH INSTEAD OF THAT IDIOTIC ASS OF JAMES JOYCE I actually like him BUT FUCKITY FUCK'S FUCKING SAKE I ALSO HAVE A MATH TEST TOMORROW BUT I PRIORITIZED ENGLISH LITERATUREEEEEKDKDKSKKSKSKSK 11.43 pm

[georgiaswarr]

read an excerpt of my unfinished jadeellis fic

i started writing this over a year ago and kind of abandoned it, but with the iwbft reread happening i had to think about some of the scenes again, so i thought i'd post a part of it that i'd already written and really enjoy.

for context: jade and ellis met at a gala for the first time at the beginning of iwbft week and hit it off, ellis had a breakdown in the stairwell and jade calmed her down with chiquitita by abba.

Chapter 2

Wednesday 6 September

Rowan (11.43 am)

the boys&i are back in london now

can you come over soon? there’s a lot i need to talk about to be honest

Jade (12.15 pm)

I’ll come right after work!

Rowan (12.16 pm)

can’t wait! xxx

When she went to the boys’ apartment complex later that day, Jade was surprised to see Jimmy in the lobby in deep conversation with the doorman, Ernest. 

“Hi, Jimjam! Hi Ernest!”

Jimmy turned around and grinned at her.

“Jade!” He rushed up to her and they hugged each other.

“Good afternoon, Ms Omondi!” Ernest said.

“Hi! So all the cool people hang out in lobbies now, do they?”

“Yeah,” Jimmy said. “Lister accidentally broke something and I didn’t feel like dealing with the aftermath of that so I thought I’d catch up with Ernest a bit. But I’ll come up with you. I have to face the music eventually.”

“You know, somehow Lister breaking something in the first week of your hiatus is not very hard to believe.”

Jimmy snorted. “My thoughts exactly.”

The two of them said goodbye to Ernest, who made Jimmy promise to find him whenever things got unbearable in the Ark household, and stepped into the lift.

“So, how are you feeling after everything?” Jade asked on their way up to the flat.

Jimmy shrugged. “I don’t know. It’s all pretty weird right now. I don’t think I’ve fully processed everything that’s happened yet, to be honest.”

Jade ruffled Jimmy’s hair. “I’m sorry things are a fuckhub right now, Jimjam.”

Jade had always felt protective of Jimmy. Back when they both lived in rural Kent, they were two of the only out trans people in their town, so he’d often come to her for advice or when he needed to vent about cis people. Naturally, she’d immediately adopted him as her third little brother.

Jimmy smiled. “Thanks, Jade. We’ll get through it. With therapy and stuff.”

Jade chuckled as the two of them reached their floor and went to face the music.

Rowan, Lister, and, to Jade’s surprise, Cecily Wills, were on the second floor of the flat, standing in front of the crime scene. On the ground was a very expensive painting, knocked off the wall, frame smashed and torn right down the middle. Lister noticed Jade and Jimmy first and smiled at them bashfully. Jade stepped up behind Rowan and wrapped her arms around his waist. He jumped and turned around.

“It’s just me, mate.”

“Jade! Help us,” he pleaded and gestured to the wrecked painting with a look of despair on his face.

“What happened, then?”

“Allister over here just devalued a 10’000-pound piece of art,” Cecily jumped in.

Lister rolled his eyes. “In my defence, I’m the stab-ee with a broken leg, so this sort of thing is to be expected.”

Rowan nodded. “Yeah, it could’ve been much worse, Cecily.”

Lister stared at Rowan, surprised that he’d stand up for him.

“Of course.” Cecily sighed. “Just be more careful next time, babe. That charity auction with Jacques Flaubert was a big milestone in your career so I don’t know how I’m supposed to tell him we just broke his piece.”

“Maybe you just shouldn’t give a shit?” Jade suggested. Cecily raised an eyebrow. “I mean, didn’t you hear about Jacques Flaubert’s blatant aphobia?”

She frowned. “I did not.”

“He said some pretty fucked-up stuff about asexual people and refuses to apologise, so maybe it’s a good thing Lister broke that painting.”

Lister snapped his fingers. “Exactly! We don’t support aphobia in this house!”

“Plus, you’re superstars, so if anything a tear in the painting will increase its value,” Jade continued. “‘Expensive painting broken and patched up by boyband auctioned off for tons of money’ has a certain ring to it, doesn’t it?”

“Jade, you are speaking my language,” Lister said. Jade winked at him, which made his grin even wider.

“Alright, I’ll go put this painting somewhere safe for the time being. Jimmy, make sure Lister doesn’t break anything else on his way through the flat,” Cecily ordered.

“What, why me?” Jimmy said.

“Because Rowan needs a well-deserved time-out to talk to his sister.”

“Are you saying you don’t want to spend time with me?” Lister asked Jimmy. His tone was teasing, but Jade sensed some genuine hurt behind the question.

“Of course not! Come on, let’s go to the kitchen.” Jimmy touched Lister’s back and guided him to the stairs while Cecily picked up the shredded painting and followed them.

Once all three of them were out of sight, Jade turned to Rowan to finally get a good look at him. He looked tired. His hair, which had previously been in twists, was undone and he still had traces of a healing wound where the brick had hit him.

He smiled at her weakly. “Hi.”

“Hi. Wanna play dark souls?”

***

“So, how exactly did Lister end up breaking a 10’000 pound piece of art?” Jade was standing in front of Rowan’s impossibly large window and looking at the London skyline while Rowan was installing the video game.

“He was prematurely trying to be independent and walk up the stairs alone. Next thing you know our flat is in need of some new decoration. You coming?”

“Sure.” Jade took one last good look at the stunning view, then she sat down next to Rowan on his bed, leaning against the headrest, and grabbed the controller he was offering her. Rowan pressed play and the screen started to load. “To be completely honest, though, I would’ve expected you to be much angrier at Lister for that. What happened to the guy who didn’t talk to his bandmate for several months after the suitcase incident?”

“Come on, I’m not that mean. We’ve all been through a lot these past few weeks. I don’t blame him for trying to regain some sense of control.”

“Shit, when did you turn into a psychoanalyst?”

“I don’t know. Scary stuff.”

Jade chuckled. “So… speaking of going through a lot… wanna talk about what’s been happening?”

Rowan nodded slowly and paused the game. “What do you need to know?”

“Well, I haven’t really heard much from you except that you’re okay. Physically, at least. I mostly know what the general public knows.”

“Yikes, Jade, we can’t have you compare yourself to the general public.”

And so Rowan told her everything that happened. From the intimate details of their lives being leaked to the press, to the awful meet-and-greet, them almost being forced to sign their lives away with the new contract, Jimmy running away to their hometown, Bliss ending things with him and how Lister wound up with a broken leg and a stab wound. 

“So yeah, now we’ve decided to go on hiatus for the foreseeable future.”

“That’s a good thing though, right? I mean, you all deserve a shitload of rest after everything.”

“Yeah! I mean, of course. But… I don’t know.”

“But what?”

“Well… I feel like having all this free time might mean we have to… face some stuff. Like, Jimmy and I had the worst fight of our lives, which we haven’t even talked about yet, I have no fucking idea where… everything has left Lister and me, and I just... really miss Bliss. I mean, now that we’d actually have time to see each other it doesn’t amount to anything anymore.”

Rowan. Even after going through the worst week of his life, all he thought about was other people. “But you’re still friends, right? So you will still see each other?”

Rowan shrugged. “We haven’t really talked since. And I think I need a bit of time to get over her, to be honest.” He looked down at his hands and blinked.

“Come here.” Jade opened her arms to her brother and he sunk into them, finally letting his tears fall freely.

“I think it’s good that you’re on hiatus. It means I get to see you more.”

Rowan chuckled through his tears. “I’m quoting this back at you next time you get annoyed at me for throwing a shell at you in Mario Kart.”

Jade laughed. “Oof, dug my own grave there.”

For a while, they stayed in the same position, allowing Rowan to calm down. Finally, he declared, “I think I want to cut my hair and dye it pink.”

Jade raised an eyebrow at him. “So basically like my hair?”

“Um, no… there’s many different shades of pink, Jade.”

“Right, of course.”

“I’d dye it pink even if your hair was a completely different colour!”

Jade threw her hands up. “Yes, yes! Of course! Do what you want!”

“Yes! Thank you!”

Jade snorted while Rowan rolled his eyes, a smile on his lips.

“You know, Alex is gonna miss redoing your twists every few weeks, though. Just FYI.”

“How would you know what Alex would miss?”

“He told me when I saw him the other day. He said ‘Jade, you know what the best part of my job is? Doing your baby brother’s hair. I’d just hate to lose that last shred of joy’,” she said in a dramatic voice.

“Well, it’s not like there’ll be that much styling in this band for the time being anyway. Besides, Lister’s hair really seems to be growing out, so I’m sure he’ll find plenty to do there.”

“Yeah, but that’s white people hair.”

“Good point. I’m still changing mine though.”

“Of course. I’m sure you’ll look great either way.”

“Thank you. I know.” They grinned at each other. “When did you see Alex?”

“Oh, I ran into him at this gala the other week.” Jade thought back to their last interaction. Shortly after listening to Chiquitita with Ellis, Alex texted Ellis that he wanted to leave. Jade didn’t want to intrude so she stayed behind. That was more than three weeks ago and she hadn’t spoken to either of them since.

Speaking of Ellis...

“I just thought of someone who could help you out with that newly empty wall.”

[cosmicanger]

Chris Oh, Flicker, 2023, acrylic enamel on antique mirrored brass candle holder with beeswax candles, 23.50 x 11.43 x 12.7 cm, 9 1/2 x 4 1/2 x 5 in

[annislittleshopofhorrors]

Anni sorry to ask you again, the timestamps of Dustbin pic please

No problemo 😉

Dustbin's pic was taken almost the same time when he posted it (today, 5.27 p.m. Portugal time)

Sabrina's pic was taken two days ago (Sept 14, 11.43 a.m. Portugal time)

And it looks like Jenn isn't in Portugal.

[jaguarmen99]

4 名無しさん＠涙目です。(庭) [US] sage 2023/12/01(金) 11:41:50.80 jNrPSh2K0ヘリ落ちた時は何も言わんのにオスプレイの時だけ大騒ぎするのはなぜ？103 名無しさん＠涙目です。(大阪府) [JP] sage 2023/12/01(金) 12:30:46.94 wAuehSNj0>>4自衛隊のヘリが墜落したときも騒いでただろ161 名無しさん＠涙目です。(山口県) [AU] age 2023/12/01(金) 13:19:51.24 4Epjb7Cs0>>4ヘリから部品が落ちても大騒ぎですよ8 名無しさん＠涙目です。(神奈川県) [US] sage 2023/12/01(金) 11:43:13.75 jwXNAX0j0ぶっちゃけ、ブラックホークの方が落ちてる。11 名無しさん＠涙目です。(庭) [US] 2023/12/01(金) 11:44:11.43 HihYabVG0マスコミですら特別事故が多いわけではないって言ってんのに12 名無しさん＠涙目です。(神奈川県) [MY] 2023/12/01(金) 11:44:40.64 HvPZKlk40落ちたのすごい嬉しかったんだろうな

続・妄想的日常

[covidsafehotties]

From 2022

Highlights

"The questionnaire was completed by parents of 147 children — 70 children with a diagnosis of immunodeficiency (47.6%) and 77 who were immunocompetent (52.4%)."

" Immunocompetent children were more significantly affected by long-COVID than those immunocompromised. Its prevalence in the first 12-week post-infection was 60.0% and 35.7% in these groups, respectively. Beyond this period, these percentages had dropped to 34.6% and 11.43%, respectively."

"Children who were immunocompetent reported more often symptoms of fatigue, reduced exercise tolerance, and difficulty concentrating. Meanwhile, there was a slight increase in complaints of gastrointestinal symptoms in immunocompromised patients."

"The risk of developing long-COVID increased with age and COVID-19 severity in both groups. Furthermore, the daily activities of immunocompetent children were limited more frequently (41.8%) than for those who were immunocompromised (25%)."

Limitiations- It's a survey. Not a lot of medical data to play with, but symptoms and behavioral reports can be useful in diagnosing children.