#CBD isolate California

[caliborn123]

Why should you buy bulk CBD isolate in California? 

CBD Isolate is a form of cannabidiol, which is a chemical compound present in the cannabis or hemp plant. Unlike the other CBD products that only produce the liquid, bulk CBD isolates in California is actually white, crystalline powder. 

Understanding CBD isolates:

CBD Isolates, often referred to as CBD crystalline, are the most potent CBD products on the market, typically offering potency levels of 99%+. CBD isolate is derived directly from the cannabis plant and then packaged for sale with minimal alteration made to it. 

CBD isolate typically comes in a crystalline powder form, which is created by taking the hemp plant and stripping away all other substances, including other cannabinoids, oils, chlorophyll, and waxes.  

Product benefits of CBD Isolate: 

You or your customers might be wondering what the benefits are of CBD isolate, especially compared to other CBD products or cannabis products. Some of the main advantages of CBD isolate include: 

Affordability 

On a per-gram basis, CBD isolate is nearly always cheaper than all other CBD products. For example, you could purchase 500mg worth of 99% CBD crystals and get more CBD for your buck than if you bought 10% strength CBD oil. 

Application 

When you have nothing but pure CBD in front of you, it is easy to measure the exact quantity needed. Since some customers may report irritating the side effects from using too much CBD, it can provide peace of mind to be able to measure out the exact amount of pure CBD they are using. 

Zero THC 

While THC is desirable for some people, others do not want to run the risk of using any THC. Some people don’t like the psychoactive effects of THC. By using pure CBD, there is no need to worry about this. 

Which product types are ideal for CBD isolate? 

Bulk CBD isolate in California is ideal for applications in which chemical purity and easy dosing are desirable. While cannabidiol isolate does not contain any of the terpenes, flavonoids, or minor cannabinoids that may increase the effects of cannabidiol in the body, it is the most reliable type of cannabidiol extract to work with. It offers the most significant degree of purity. 

[buddhawell]

Cannabidiol (CBD) is available in many forms, including oils, capsules and creams. The ideal dosage varies depending on its form and method of use. What is the correct dosage of CBD products is a question that each of us asks. CBD use is very individual and ideally, you have to try more options before coming to your "ideal" dose. Our practical guide is to help you choose the right dosage for you.

We don't have to introduce CBD to you - we all know that it is an active substance in the cannabis plant. CBD-containing products may have certain therapeutic benefits and are not psychoactive.

What is the effective dose of CBD?

CBD generally has very low toxicity. This means that it is not toxic even at higher doses. However, each individual has a differently sensitive endocannabinoid system, and therefore everyone responds differently to CBD. A number of scientific studies have been conducted on the effective dose of CBD, the findings of which are as follows:

In clinical trials, the researchers used various oral (oral) doses of CBD in the range of 100-800 mg per day. Some studies use even higher doses. A specific study reported an improvement in psychosis after taking 1200 mg of CBD daily for several weeks. In another study, people with schizophrenia reported benefits after taking increasing doses of 40-1280 mg CBD daily for 4 weeks. In a study of the effects of CBD in people with Parkinson's disease and psychosis, six participants showed a significant improvement in symptoms at a dose of CBD 150 mg daily.

For CBD dosing, "less is sometimes more"

The ideal dosage of CBD depends on a number of factors - the dosage always depends on age, gender, weight, current health status, metabolism and possibly the specific health problem whose treatment we want to support. Because each individual is unique, each must determine their own dosage. Some will need only a small amount of CBD, while others will require a higher dose to experience the same effects.

If CBD is new to you, we recommend starting with small doses - for example with CBD oil: 2 drops twice a day and you can start increasing later - depending on your condition. CBD may take time to work. Usually, the first results appear within 2 weeks of use.

Think of a simple rule: always start with small doses and gradually increase. In general, it's great to realize that once you start to feel better with a CBD product, you've come across your ideal dosage and you've practically won! If the CBD dose suits you, there is no need to increase it. Stay on the ideal dose for a while and over a few months you can start gradually reducing the dose.

At the moment, our strongest and most therapeutic CBD tincture is “Ringo's Gift” which contains 2500mg of CBD Isolate. So, if you’re just starting your journey with CBD, this tincture would surely last you quite a while.

[motusactive-blog]

Should Athletes incorporate CBD in their diet?

It takes a lot to be an athlete, lots of training, practices, exercise and proper diet. These are essential to be able to perform well.

Aside from all that, they should also do many things to improve their performance. This includes eating healthy foods, staying hydrated, lots of developing physical improvements on workouts, and training exercises specific to the sports that they are joining. And don't forget getting adequate rest, too.

It takes a lot to become an athlete, they say. Many athletes have said: “It takes commitment and perseverance. Sometimes you can reach a point wherein you will forget what it means to be a normal person. You should do a lot of balance with your lifestyle and discipline yourself not to eat some of the foods you like.”

This is the reason why some athletes stop, talking about those who are passionate but don’t have discipline. Although they love their sports, it becomes hard for them to give up their lifestyle.

But all is not lost, there is an available option for athletes to improve themselves and continue with the sport they are passionate about. There is an available supplement that they can take, those that contain CBD compound. If you want to want to keep your sport spirit alive, then Shop CBD Supplements in Los Angeles and consume it.

CBD is short for Cannabidiol - a compound found in the cannabis and hemp plants. CBD is the one of the most beneficial active ingredients in hemp, and it has become very popular for people and pets. Unlike what others think, CBD is a lot different from THC.

Hemp & cannabis can contain both CBD and THC, which have different effects. THC creates a mind-altering “high” which is commonly associated with consuming cannabis. On the other hand, CBD is different because, unlike THC, it is not psychoactive and has virtually no side effects. This only means that CBD does not change a person’s state of mind when using it.

It is said to have controversial use, but that is only because a lot of people are still not educated with this. In fact, CBD has a lot of health benefits to everyone. It can treat a lot of diseases and help in relieving some of it also. In fact, the most preferable time to consume CBD is before any workout. Are you convinced to take this? If so, then Shop CBD Before Workouts at the best prices.

One good thing about CBD is that it is even helpful to athletes. This is perfect for those athletes who have thought they have already done their best in training and exercise but still feel that what they do is still not enough.

Research has connected CBD with numerous potential health benefits, and it is also reported that these include pain relief and relief from various neurological disorders thus making this as an option to those who regularly engage in physical activity.

Athletes need adequate rest and sleep and this is where the benefit of CBD starts. It improves sleep quality. Getting more and better sleep can actually help athletes achieve greater training gains. Athletes who consume CBD are reported to have ease in going to sleep and a more restful night.

Also, one benefit of CBD is for pain relief. Athletes really have a hard time dealing with pain and injury. This is what they are experiencing in training and in the actual competition. There is a study that was published in Current Neuropharmacology and shares that CBD has the ability to ease both chronic and acute pain, and it does so without negatively impacting the central nervous system.

Another benefit of CBD is how it acts as an anti-inflammatory. According to Antonio De Rose, a co-founder and COO of Marijuana Fitness Nutrition in Boulder, Colorado: “CBD can attach to the CB2 receptors in the Endocannabinoid system, encouraging the reduction of inflammation in many areas of the body including tissue, the brain, intestines, and some studies even indicate its therapeutic use for conditions like fibrosis and rheumatoid arthritis.”

Are you ready to take the maximum benefits of your exercises? If so, Order CBD Products Los Angeles, CA right now and incorporate it in your diet. Live healthy!

[dabjuice-blog]

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[caliborn123]

How beneficial is bulk CBD isolate in California? 

CBD Isolate is a form of cannabidiol or a chemical compound in the cannabis or hemp plant. Unlike other solutions that produce liquid, CBD isolate always comes as a white, crystalline powder. Often referred to as CBD crystalline, the CBD Isolates are the most potent CBD products in the market, typically offering potency levels 99%+. 

The term “isolate” is accurate because CBD molecules must be isolated from all the other cannabinoids like THC so that only CBD remains. Unlike full-spectrum CBD products, bulk CBD Isolate in California does not contain any THC, which is the psychoactive component of cannabis or hemp. The CBD isolate is an option for those who want to experience the potent therapeutic effects of CBD without even the slightest trace of THC. 

Regarding CBD (cannabidiol), most products on the market which contain a certain percentage of other cannabinoids and the plant materials. For example, the oils procured from hemp plants generally have 60-80% CBD, while highly refined solutions produced through distillation typically contain 90%+ CBD. The CBD isolate takes this purification process a step further. 

What is CBD isolate? 

CBD isolate is actually the purest form of cannabidiol that contains >99% pure CBD. To produce the CBD isolates, the cannabis or hemp solution must undergo a complicated distillation process. Unlike other solutions that produce liquid, CBD isolate always comes as a white, crystalline powder. 

How is CBD Isolate Made? 

To make bulk CBD isolate, hemp plants must undergo several forms of distillation. First, the hemp plant must fully mature for the chemical compounds to be entirely present. Then, oils must be extracted from the plant through a PX1 or PXP system. The resulting solution is known as full-spectrum CBD. This solution contains all cannabinoids naturally occurring in the hemp plant, including CBD and THC. 

Full-spectrum CBD must then be distilled to produce broad-spectrum CBD. With broad-spectrum CBD, the solution generally contains 90% or more CBD, trace amounts of THC (~0.3%), and other cannabinoids. The unwanted plant materials are then separated and removed using a process called chromatography. 

Once the chromatography phase is completed CBD, can be isolated, and the remaining materials must be removed so that only the cannabidiol remains. The next step involves a process known as winterization, which removes the excess fats and any other remaining plant materials using freezing temperatures. 

Finally, the outcome is heated to convert into pure CBD powder. This phase is called decarboxylation. As you can see, it is a very complicated and involved process to take a hemp plant and then convert it to a pure CBD powder, free of any other cannabinoids. 

Is CBD Isolate Regulated? 

The answer is no. The use of CBD isolate has yet to receive official FDA approval. However, CBD was also eliminated from the controlled substances list as a part of the Farm Bill in 2018, making it legal to be produced and distributed nationwide. THC is still a controlled substance, and so it is not yet legal in many other states in the country. Therefore, CBD isolate producers need to ensure that their products do not have THC, especially if they want to distribute their CBD products in states where recreational and medicinal cannabis is illegal. As a result, CBD products must adhere to specific regulations to ensure that they are infused with CBD isolate rather than the THC or other cannabinoids. 

[kolalabscom-blog]

Kola Labs is a CBD Extraction Laboratory in Southern California that now offers THC Remediation, Hemp Toll Processing, CBD Distillation and CBD Isolation Services. https://kolalabs.com/

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[dabjuice-blog]

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Buy CBD Online is the best CBD shop that carries over 1000+ products.  We have the best discounts on CBD Vape Juice, CBD Oil, CBD Gummies, CBD Flower, CBD pills, CBD Cream, and CBD eLiquid. We carry CBD in all strengths and sizes such as full spectrum cbd oil, broad spectrum cbd oil, and cbd crystal isolate. Some of the best tasting and most affordable CBD tinctures on our website are CBD MAN. It's important to remember that CBD products usually contain 0.00% CBD - 0.30% THC. Most of our CBD products are available in 5mg, 10mg, 25mg, 50mg, 100mg, 250mg, 500mg, 1000mg, 1500mg, 2000mg, 2500mg, 3000mg, 3500mg, 4000mg, 4500mg or 5000mg. Ordering through our website Buy CBD Online is as easy as 1-2-3. Our customer service representatives are here to answer any question you may have regarding CBD. Our secured payment checkout system accepts most credit cards, debit cards and we're also known as one of the best CBD websites that accept Bitcoin, Litecoin, Ethereum, and other cryptocurrencies. We offer free shipping on all CBD orders when you spend over $50.00+

[cbdmoonrocks-blog]

The Moon, The Mantle, And A Mars-Sized Tragedy

Despite the fact that it is our planet's closest neighbor in Space, Earth's enormous Moon can shroud a considerable lot of its old insider facts very well as it does its charming, confusing move around our planet- - reflecting daylight like a mirror into the twilight sky over the Earth. Our Moon is a strange motivation for verse and fantasy, just as a long-standing representative wellspring of franticness. In any case, where did Earth's Moon originated from? The main hypothesis clarifying our Moon's old birth is known as the Giant Impact Hypothesis, which suggests that our Moon appeared as the consequence of a calamitous impact between the antiquated Earth and a meandering, not well featured Mars-sized protoplanet that cosmologists have named Theia. In September 2016, planetary researchers reported that their information affirm one specific situation that clarifies this heartbreaking impact previously, recommending that the moving Theia collided with Earth- - and pummeled it like a bowling ball hitting a watermelon.

About 4.56 billion years prior, when our infant Solar System was still during the time spent framing, Theia hit the proto-Earth and shot quite a bit of our newborn child planet to bits. Because of this terrible old crash, Earth's stones didn't only dissolve - they disintegrated! The components in those Earth rocks transformed into a gas similarly that bubbling water transforms into steam. At last, what survived from the first pre-crash Earth chilled, and it again framed a strong planet. What survived from the antiquated impact turned into the Moon.

This is the most recent translation of a decades-old hypothesis clarifying where Earth's lunar friend originated from, and it depends on ongoing estimations of components contained in both the Earth and its Moon. The planetary researchers suggest that their new estimations, which they have acquired of a component found inside both Earth and lunar rocks, presents a test to the main speculation of our Moon's puzzling roots. Incredibly little varieties in the isolation of the isotopes of potassium among Earth and Moon were shrouded like a lost fortune underneath the discovery furthest reaches of investigative methods as of not long ago.

Nonetheless, this changed in 2015 when Washington University in St. Louis (WUSTL) geochemist Dr. Kun Wang, at that point a Harvard Origins of Life Initiative Prize postdoctoral individual,CBD MoonRocks and Dr. Stein Jacobsen, teacher of geochemistry at Harvard University in Cambridge, Massachusetts, built up a procedure for examining these isotopes with a precisions multiple times superior to the best of every single past technique.

Dr. Wang and Dr. Jacobsen report in their new examination that isotopic contrasts among Earth and Moon rocks uncover the principal test proof that can segregate between the two driving situations clarifying lunar beginnings. As per the main situation, a low-vitality impact leaves afterward both a proto-Earth and Moon covered in a clouding silicate climate; in the second, a significantly more cataclysmic impact disintegrates Theia and the vast majority of the proto-Earth, extending to make a massive superfluid plate out of which Earth's Moon eventually shapes.

The new isotopic examination reinforces the case for a high-vitality situation, and it is distributed in the September 12, 2016 online release of the diary Nature. "Our outcomes give the primary hard proof that the effect truly did (to a great extent) disintegrate Earth," Dr. Wang remarked in a September 12, 2016 WUSTL Press Release. Dr. Wang is an associate educator of Earth and Planetary Sciences in the School of Arts and Sciences at WUSTL.

The Lunatic, The Lover, And The Poet

Earth's shimmering Moon balances suspended in the twilight night sky over our reality. In view of its incredible excellence and strange, gleaming evening time nature, Earth's Moon all through the ages has been the motivation for stories, legends, verse, and supernatural stories. It has likewise filled in as an antiquated image for that which is ladylike, just as for sentimental love and lunacy. Some society stories and youngsters' accounts notice the "Man in the Moon", on the grounds that - with a smidgen of creative mind - it would appear that a man's face has been carved on our lunar friend's far off surface. Different stories include a "Moon Rabbit". Dream and fiction aside, our Earth's dumbfounding Moon is an undeniable little world in its own right. Earth's Moon has been with us nearly from the very beginning, when our Sun and its combination of planets, moons, space rocks, and comets, were first shaping about 4.6 billion years back. It is likewise the main world past Earth that we have strolled after, deserting our impressions in the Moon-dust- - a quiet declaration murmuring that once we did exist, and that we had been there.

Despite the fact that most planetary researchers feel that Earth's Moon is the snitch story relic of an old calamitous impact among Earth and the catastrophe that was Theia, endeavors to affirm this driving hypothesis of lunar development have been troublesome. This is on the grounds that exhibiting the truth of this proposed old wreck relies upon estimations of the proportions between the isotopes of silicon, titanium, oxygen, and others. These proportions are known to vary all through our whole Solar System, and the extraordinary similarity between our planet and its Moon negates hypothetical models of the old disaster. The explanation is that these models suggest that our Moon would have shaped principally from the destruction of the disastrously pounded Theia. Consequently, our Moon would need to be compositionally not the same as Earth.

The eight significant planets of our Solar System have their own one of a kind arrangement that can be controlled by researchers contemplating isotopes. Isotopes are variations of concoction components, for example, the component oxygen seen in astronomical examples. All together for the Giant Impact Hypothesis to fill in as a clarification - recommending that an interesting Solar System object collided with the antiquated Earth, and that its subsequent crash related flotsam and jetsam made a critical commitment to the organization of Earth's Moon- - the Earth and its Moon should show contrasting proportions of essential isotopes. Be that as it may, this isn't the situation - our planet and its secretive Moon are practically indistinguishable twins in sythesis.

In 2001, a group of planetary researchers from the Carnegie Institution of Washington detailed the most definite estimation so far of the isotopic marks of Moon rocks. To the researchers' astonishment, they found that the stones got from the Apollo missions of the late 1960s and mid 1970s contained an isotopic mark that was indistinguishable from Earth shakes, and were not the same as practically the entirety of different bodies in our Solar System. Since the greater part of the flotsam and jetsam that entered circle around our early stage planet in the long run coagulated to shape the Moon, and it was then idea to have originated from the pummeled Theia, this new perception was astounding. In 2007, planetary researchers from the California Institute of Technology (Caltech) in Pasadena, California reported that there was not exactly a 1% chance that Theia and Earth had indistinguishable isotopic marks. An investigation distributed in 2012, of the titanium isotopes found in the Apollo lunar examples indicated that Earth's Moon has a similar piece as Earth. This contentions with what is normal if Earth's lunar friend had been brought into the world a long way from Earth's circle or from Theia.

So as to clarify this improbable likeness, planetary researchers needed to think of an approach to frame the Moon for the most part from the Earth- - and not Theia. Dr. Wang was captivated by another PC model that had made its presentation in the spring of 2016 at the yearly Lunar and Planetary Science Conference. In this new PC model, Theia collided with the newborn child Earth with such viciousness that both Earth's mantle and Theia disintegrated.

Mammoth effects are for the most part thought to have been visit events in the beginning of our Solar System. In reality, supercomputer reenactments demonstrating a mammoth effect are reliable with estimations of the precise energy of the Earth-Moon framework and the little size of the lunar center.

The Moon, The Mantle, And A Mars-Sized Tragedy

In the 1970s, two free groups of astrophysicists originally suggested that Earth's Moon was the consequence of a brushing kind of impact among Theia and the proto-Earth. For sure, the Giant Impact Hypothesis clarifies very well various significant perceptions, for example, the enormous size of the Moon comparative with our planet.

The extraordinary amount of vitality freed in the cataclysmic effect occasion, and the inevitable re-growth of launched out material in Earth circle, would have liquefied the external shell of our planet, in this manner making an expanse of burning hot and searing magma. The infant Moon would likewise have had its own magma sea. Appraisals for the profundity of the antiquated lunar sea extend from around 300 miles to the whole span of the Moon, which is 1,079 miles.

Planetary bodies that are conceived in contrasting areas of our Solar System have diverse isotopic arrangements. Consequently, unique isotopic marks fill in as "fingerprints" for planets and shooting stars got from a similar item. The possibility that Theia- - a meandering outcast from somewhere else in our Solar System- - coincidentally had a similar isotopic signature as Earth is incredibly little.

Along these lines, the Giant Impact Hypothesis had a major issue. It had the option to represent countless the physical qualities of the Earth-Moon framework yet not their geochemistry. The isotopic organization research set off an "isotopic emergency" for this in any case preferred theory.

[remymars90-blog]

Best Unknown Facts about CBD

“It’s promising in quite a few distinct healing avenues because it’s noticeably secure,” said James MacKillop, co-director of McMaster University’s Michael G. DeGroote Center for Medicinal Cannabis Research in Hamilton, Ontario.

Last year, the F.D.A. Authorised Epidiolex, a purified CBD extract, to deal with rare seizure disorders in sufferers 2 years or older after 3 randomized, double-blind and placebo-managed medical trials with 516 patients that showed the drug, taken along side other medicines, helped to lessen seizures. These sorts of research are the gold trendy in remedy, wherein participants are divided by way of danger, and neither the problem nor the investigator is aware of which organization is taking the placebo or the medicine. 

While there's hope for treating other conditions with the plant extract, Epidiolex remains the most effective CBD-derived drug approved by the F.D.A. Most of the studies on cannabidiol has been in animals, and its present day recognition has outpaced technology. “We don’t have the one hundred and one direction on cbd isolate uk found out yet,” said Ryan Vandrey, an accomplice professor of psychiatry and behavioral sciences at Johns Hopkins University School of Medicine.

Does CBD assist tension and PTSD?

For students with generalized social tension, a four-minute speak, with minimum time to prepare, can be debilitating. Yet a small test in the journal Neuropsychopharmacology located that CBD seemed to lessen anxiety and cognitive impairment in patients with social tension in a simulated public talking project.

However, a double-blind observe found healthful volunteers administered CBD had little to no alternate in their emotional response to ugly pictures or words, compared to the placebo group. “If it’s a chilled drug, it should trade their responses to the stimuli,” stated Harriet de Wit, co-creator of the take a look at and a professor in the University of Chicago’s branch of psychiatry and behavioral neuroscience. “But it didn’t.”

Many squaddies go back home haunted by war and PTSD and often keep away from sure sports, places or human beings associated with their stressful activities. The Department of Veterans Affairs is investment its first look at on CBD, pairing it with psychotherapy.

“Our top treatments attempt to break the association among reminders of the trauma and the worry reaction,” said Mallory Loflin, an assistant adjunct professor at the University of California, San Diego and the observe’s important investigator. “We think that CBD, as a minimum in animal fashions, can assist that procedure happen lots quicker.” While large medical trials are underway, psychologists say there isn’t compelling proof yet as to whether or not that is a feasible treatment.

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[shikaiproducts-blog1]

What to Look for in an Effective CBD Cream or Lotion

CBD is trendy, with people from all walks of life using it as a part of their daily skincare routine. If you’re looking to buy CBD online or in stores, you might wonder if all CBD skincare products are the same. Unfortunately, they aren’t. Among the many brands in the marketplace, some sell either ineffective, low-quality CBD lotion, or products that just aren’t enjoyable to use.

Luckily, there are certain factors that only the best brands feature, which can give you peace of mind while shopping. Here’s what to look for in an effective CBD cream or lotion. The Form of CBD Matters First and foremost, the CBD cream you’re buying should contain a generous concentration of CBD. Along with other skin-loving ingredients, CBD is probably the most prominent ingredient featured on the label, so it would make sense that there’s a meaningful concentration in the actual product itself, right? It should, but many brands use CBD more as a marketing tool rather than a product benefit. And the form of CBD used in the product matters. When shopping for CBD topical products, CBD isolate is the best form to look out for because it is white, odorless, and is just pure CBD without other components. As a rule of thumb, you should look for around 125 milligrams of CBD per ounce in a product. This high concentration will ensure that you’re getting the effective CBD lotion or cream you’re after. If a product contains CBD oil, however, there are always other components in the mix, including terpenes, flavonoids, and more. This can impact the overall concentration and effectiveness of CBD topicals, as only a percentage of the oil is actually CBD. This means that if a brand lists 1,000 milligrams of CBD oil on a product label, only a fraction of that is actual CBD. Additionally, there’s a difference between how your body processes the CBD in edibles versus topicals. So, while you might want flavonoids or terpenes in something you’d ingest, there’s no reason to rub smelly stuff on your body. While some brands might try to “wow” you with high milligram counts of CBD oil in their products, it’s important to educate yourself as a consumer about the different forms of CBD and go with a topical product from a trusted brand. Otherwise you might end up applying a brown or green lotion with a “weed smell”—which likely isn’t what you were looking for on your search for an effective CBD lotion. Quality Secondary Ingredients Besides CBD, you want the product to be an effective topical solution by itself. For this reason, you should see what other ingredients are in the CBD cream or lotion. Ingredients such as vitamin E, shea butter, and avocado oil help nourish and soothe your skin while others like menthol and camphor elevate the experience with a cooling effect. You should look for brands that source their ingredients from nature and create a pleasant experience when you use their CBD topical solution. Stringent Batch Testing Not all CBD is the same, so where a brand sources their CBD and the method with which they test their products matters. In a perfect world, all brands would test their CBD for safety and consistency, but that’s not always the case. Look for a responsible brand that tests every batch of their CBD cream or lotion and has a feature that allows you to check the individual batch number on your product as well. It’s this kind of accountability and commitment to product quality and safety that separates the best brands from the rest. Buy From a Company with Experience It’s no secret that CBD is super popular these days, and it seems like there’s a new CBD company or product popping up every week. However, sourcing and producing products with premium, effective CBD isn’t easy—it takes experience. That’s something novice companies just don’t have, and their inexperience shows in the quality of their products. Not all CBD lotion or cream is the same, so do your research and choose a brand that has decades of experience in the skincare world and is known for using quality, natural ingredients in their products. About ShiKai It’s been nearly 50 years since ShiKai was founded, and their commitment to quality ingredients with skin-nourishing benefits continues to this day. The company was started by Dr. Dennis Sepp, an organic chemist with a passion for natural, ayurvedic ingredients. Five decades later ShiKai is still family-owned and operated, and continues to produce all of their products in their Santa Rosa, California facility. Their latest line of CBD products is formulated to have a high concentration of CBD, along with other skin-nourishing ingredients like borage oil that can help with a number of skin-related issues. Whether you’re shopping for CBD lotion, creams, or other topical solutions, ShiKai Products are the clear choice. Shop their line of CBD skincare essentials at Shikai.com Original Source: http://bit.ly/2OMTduE

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[naughty-rwby]

Scientists re-Create Marijuana’s Active Ingredients with Brewer’s Yeast

Fermentation-powered brewing has been getting people drunk for thousands of years. Soon, it could be getting them high, too.

In research announced on Wednesday by the University of California at Berkeley, a team of synthetic biologists modified brewer’s yeast to produce a range of cannabinoids, which are compounds in cannabis that affect the brain and body. The technique opens up the possibility of circumventing the need for large-scale plant cultivation, and the findings could conceivably make high-quality, reasonably priced cannabinoids much more accessible for pharmaceutical development and recreational consumer products.

For longtime cannabis advocates, though, this new technology might bring corporate interests one step closer to controlling a market they’re fighting to keep democratic.

To brew cannabinoids—the most famous of which are tetrahydrocannabinol and cannabidiol, or THC and CBD—the operation looks much like a traditional brewery, says Jay Keasling, the Berkeley professor of chemical and biomolecular engineering who led the research. “Essentially what we’ve done is taken yeast, which would normally produce ethanol for beer or wine, and we put in it the gene for producing cannabinoids,” he says. “We have the opportunity to produce very pure molecules.”

THC and CBD are only two of about 100 documented cannabinoids in existence. THC is the psychoactive element of cannabis that makes users feel high, while CBD is the element that can provide a feeling of calm. Beyond primarily recreational consumer products such as the gummies and oils currently found in legal weed dispensaries, preliminary research is promising on both THC’s and CBD’s potential uses as pharmaceutical therapies for managing conditions such as pain and anxiety.

Obtaining large quantities of reliably high-quality cannabinoids can be a major obstacle for scientific researchers looking for medicinal applications of the compounds, and supplying those efforts might be the most immediate upside of large-scale vat fermentation. As recreational cannabis legalization expands across America, there could be other upsides. “When they’re incorporated into products—whether that be skin creams or edibles or whatever else—you’re going to know exactly how much you’re getting,” Keasling says.

Concerns over variable CBD quality and strength have caused problems for cannabis entrepreneurs recently, especially when the debatably legal extract is incorporated into consumer products such as food.

For the dozens of other cannabinoids, no one really knows what might be possible, or what effect they might have on humans in larger, isolated doses. Because most of them appear in cannabis as trace or rare chemicals—and some of them, known as unnatural cannabinoids, don’t appear in the plant at all—meaningful research on them has so far been impossible. “We haven’t had access to test, and this will give us access to those compounds,” Keasling says. “The yeast would produce the cannabinoids in, say, a day or a couple days.”

Keasling is one of the research pioneers of this yeast-based approach to chemical production, which is a type of synthetic biology. The technique is still in its exploratory stages and has been met with some skepticism, but it is currently being used to manufacture a number of products, including insulin and lab-grown leather.

In 2014, Keasling used yeast to produce the antimalarial drug artemisinin, which occurs naturally only in the sweet wormwood plant. Agricultural supplies of the drug have traditionally been erratic, but as Keasling’s synthetic-biology alternative went to market, the natural supply of the drug stabilized and the price dropped, which neutralized the economic need for alternatives.

The cannabis market provides the opportunity for better timing. Large-scale cultivation of the plant in legalized U.S. states is only just beginning to move forward. With more states likely to soften their position on weed in the near future, demand could skyrocket not just for the plant’s flowers, but especially for the cannabinoid-based extracts that provide an easier point of entry for novice experimentation or health products. Fermentation has the potential to provide a quicker and more sustainable way to meet those needs: Conventional cannabis cultivation is, ironically, not so green.

Fermentation is also less expensive, according to Keasling, because it uses less land, smaller facilities, and more limited manpower. Its waste product is mostly water, which can be safely treated with existing technologies that large-scale fermenters already use. In the case of artemisinin, Keasling says that production cost about $400 a kilogram once everything was up and running at scale. In contrast, a pound of wholesale cannabis in legalized states currently costs anywhere from $595 to nearly $3,000. That raw material would then have to be processed down to much smaller quantities of pure extracts.

Keasling has bought in to the business potential of his research. In 2017, he founded a company called Demetrix that so far has $4 million in venture-capital seed funding, and it licenses the technology he has helped develop in order to explore research and consumer-business models for vat-fermented cannabinoids. Other companies are also keen to use synthetic biology to enter the cannabis market, including the Boston-based Ginkgo Bioworks.

When it comes to research opportunities, the predictable, cost-effective production of cannabinoids is likely good news, but it could be a problem for people who want legalization to preserve individual citizens’ right to grow their own weed and to sidestep the drug’s looming corporatization. A bill introduced to legalize cannabis in New York has been criticized by cannabis advocates for excluding home growers at what they say is the behest of corporate interests, and the potential to circumvent the plant entirely could give Big Pharma easier control over who can or cannot access cannabis’s potential, and how much they have to pay to do so.

Still, synthetic biology’s potential to give scientists a deeper and more complete understanding of cannabinoids’ possible benefits could help people with any number of ailments. “I wouldn’t be surprised if there’s a blockbuster drug in there,” Keasling says. “We just don’t know.”

[rjzimmerman]

Excerpt from this article from My News LA:

The U.S. Fish and Wildlife Service Wednesday announced a recovery plan for the endangered Southern California population of mountain yellow-legged frogs.

The finalized plan, developed in response to legal action by the Center for Biological Diversity, calls for a wide array of recovery actions and research efforts to deal with the multitude of threats to the survival of the amphibian.

“With so few of these frogs left, it’s a relief to finally have a plan in place to help them survive,” said Jenny Loda, a CBD biologist and attorney dedicated to protecting rare amphibians and reptiles. “Non-native predators and pollution are the major threats, so this plan is a big step toward saving these remarkable little creatures from extinction.”

Since the 1900s, mountain yellow-legged frogs have disappeared from nearly all of their former range in Southern California, according to the CBD. By the 1990s, fewer than 100 were thought to remain in a handful of isolated headwater streams. But the frogs are now limited to 10 precariously small populations in the San Gabriel, San Bernardino and San Jacinto mountains.

I kind of laughed at this story, because I’ve been following the recovery and discovery, in new places, of the California red-legged frog. That frog looks like this:

The frog was recently discovered in the ponds at the Whitewater Preserve, where nobody expected to find it. As a consequence, the Preserve decided to not restock the ponds with the rainbow trout that has been living in the ponds for decades, because the trout eat the frogs’ eggs. Not good for endangered species and critical habitats and such. The red-legged frogs are recovering nicely at Whitewater. I’ve seen one, and heard a lot of them in the wetlands plant growth areas. The California red-legged frog was the subject of Mark Twain’s "The Celebrated Jumping Frog of Calaveras Count.” (Interesting, maybe boring, little tidbit for you.)