#CCL2

[covid-safer-hotties]

Reference saved on our archive (Daily updates! Thousands of scientific papers and more!)

TL;DR: This is what covid does to our immune systems

Highlights • Comprehensive single-cell resolution analysis of leukocytes from pleural effusion, sputum, and peripheral blood biopsies in severe and mild COVID-19 patients. • Severe COVID-19 cases exhibit drastic T cell hyperactivation and elevated T cell exhaustion, particularly in pleural effusion samples. • Macrophages with high expression of CD163 and MRC1, indicative of M2 macrophage polarization, in severe COVID-19 patients. • Cell-specific transposable element dysreuglation in severe COVID-19 contributes to immunue disruption and disease severity.

Abstract The vastly spreading COVID-19 pneumonia is caused by SARS-CoV-2. Lymphopenia and cytokine levels are tightly associated with disease severity. However, virus-induced immune dysregulation at cellular and molecular levels remains largely undefined. Here, the leukocytes in the pleural effusion, sputum, and peripheral blood biopsies from severe and mild patients were analyzed at single-cell resolution. Drastic T cell hyperactivation accompanying elevated T cell exhaustion was observed, predominantly in pleural effusion. The mechanistic investigation identified a group of CD14+ monocytes and macrophages highly expressing CD163 and MRC1 in the biopsies from severe patients, suggesting M2 macrophage polarization. These M2-like cells exhibited up-regulated IL10, CCL18, APOE, CSF1 (M-CSF), and CCL2 signaling pathways. Further, cell type specific dysregulation of transposable elements was observed in Severe COVID-19 patients. Together, our results suggest that severe SARS-CoV-2 infection causes immune dysregulation by inducing M2 polarization and subsequent T cell exhaustion. This study improves our understanding of COVID-19 pathogenesis.

[willowreader]

This abstract outlines how Covid can impact cardiac function.

[lookchem]

75-35-4 Laser-induced Decomposition of 1,1,2-Trichloroethane

 CH2ClCHCl2 was photolyzed with a focusing geometry using the P(24) line of the 10.6 μm CO2 band (940.6 cm-1).The final products of neat photolysis were cis- and trans-CHCl=CHCl, CH2=CCl2, CH2=CHCl, CH<*>CCl, CH<*>CH, and C4H2.The relative yield of CH2=CCl2 in particular was strongly dependent on CH2ClCHCl2 pressure and sensitive to the addition of H atom containing molecules.A series of diagnostic experiments shows that the dichloroethene isomers are formed by three different processes, i.e., infrared multiphoton decomposition, collision-induced decomposition, and radical chain reaction.Infrared multiphoton decomposition and collision-induced decomposition give rise to cis- and trans-CHCl=CHCl predominantly, while the radical chain reaction generates the dichloroethane isomers in comparable amounts at high reactant pressures, the most probable initiation step being the C-Cl bond-scission reaction of the parent molecule.Formation mechanisms for other minor products are also discussed. 

[moleculardepot]

Human Chemokine CCL2 Purified Lyophilized

Human Chemokine CCL2 Purified Lyophilized Catalog number: B2017707 Lot number: Batch Dependent Expiration Date: Batch dependent Amount: 10 µg Molecular Weight or Concentration: N/A Supplied as: POWDER Applications: a molecular tool for various biochemical applications Storage: -20°C Keywords: Human CCL2 Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I…

[mohit-trendster]

नमस्ते!

फाइनल के लिए मैंने कुछ उपलब्ध किरदारों पर विचार किया जैसे कैप्टेन व्योम, फौलादी सिंह, गोजो, ब्लाइंड डेथ आदि। लेकिन नाम या स्केच से कोई कम पढ़ने वाला भी पहचान ले, इन किरदारों मे�� वह बात नहीं थी। ऊपर से, कुछ प्रकाशन तो कबके बंद हो चुके थे।

फिर मुझे "The Common Man" याद आया, जिसकी छाप करोड़ों भारत वासियों पर 6 दशकों से ज़्यादा तक बनी रही (और आगे भी रहेगी)। 2015 में पद्म विभूषण आर.के. लक्ष्मण साहब के देहांत के बाद तक उनके कार्टून प्रकाशित हुए।

अखबार में छोटा सा स्थायी कोना हो, कुछ ख़ास कॉमिक या एंथोलोजी हों, कई शहरों में प्रदर्शनियां हों, डाक टिकट हो, आम आदमी के लिए बनी एयरलाइन "Air Deccan" का ख़ास चेहरा बनना हो या भारत में 3 अलग-अलग शहरों में भव्य मूर्तियां हों...भीड़ का हिस्सा होते हुए भी सबसे अलग, The Common Man ने ये सारे किरदार बखूबी निभाए। शायद किसी और किरदार से मैं आसानी से जीत जाता, लेकिन इस किरदार के साथ अगर मैं जीतता हूँ, तो हमेशा याद रखूंगा।

#comicscharacterleague #icufc #ज़हन #TheCommonMan #ccl2

[rnomics]

Nutrients, Vol. 16, Pages 1929: Gut Dysbiosis Shaped by Cocoa Butter-Based Sucrose-Free HFD Leads to Steatohepatitis, and Insulin Resistance in Mice

Background: High-fat diets cause gut dysbiosis and promote triglyceride accumulation, obesity, gut permeability changes, inflammation, and insulin resistance. Both cocoa butter and fish oil are considered to be a part of healthy diets. However, their differential effects on gut microbiome perturbations in mice fed high concentrations of these fats, in the absence of sucrose, remains to be elucidated. The aim of the study was to test whether the sucrose-free cocoa butter-based high-fat diet (C-HFD) feeding in mice leads to gut dysbiosis that associates with a pathologic phenotype marked by hepatic steatosis, low-grade inflammation, perturbed glucose homeostasis, and insulin resistance, compared with control mice fed the fish oil based high-fat diet (F-HFD). Results: C57BL/6 mice (5&ndash;6 mice/group) were fed two types of high fat diets (C-HFD and F-HFD) for 24 weeks. No significant difference was found in the liver weight or total body weight between the two groups. The 16S #rRNA sequencing of gut bacterial samples displayed gut dysbiosis in C-HFD group, with differentially-altered microbial diversity or relative abundances. Bacteroidetes, Firmicutes, and Proteobacteria were highly abundant in C-HFD group, while the Verrucomicrobia, Saccharibacteria (TM7), Actinobacteria, and Tenericutes were more abundant in F-HFD group. Other taxa in C-HFD group included the Bacteroides, Odoribacter, Sutterella, Firmicutes bacterium (AF12), Anaeroplasma, Roseburia, and Parabacteroides distasonis. An increased Firmicutes/Bacteroidetes (F/B) ratio in C-HFD group, compared with F-HFD group, indicated the gut dysbiosis. These gut bacterial changes in C-HFD group had predicted associations with fatty liver disease and with lipogenic, inflammatory, glucose metabolic, and insulin signaling pathways. Consistent with its microbiome shift, the C-HFD group showed hepatic inflammation and steatosis, high fasting blood glucose, insulin resistance, increased hepatic de novo lipogenesis (Acetyl CoA carboxylases 1 (Acaca), Fatty acid synthase (Fasn), Stearoyl-CoA desaturase-1 (Scd1), Elongation of long-chain fatty acids family member 6 (Elovl6), Peroxisome proliferator-activated receptor-gamma (Pparg) and cholesterol synthesis (&beta;-(hydroxy &beta;-methylglutaryl-CoA reductase (Hmgcr). Non-significant differences were observed regarding fatty acid uptake (Cluster of differentiation 36 (CD36), Fatty acid binding protein-1 (Fabp1) and efflux (ATP-binding cassette G1 (Abcg1), Microsomal TG transfer protein (Mttp) in C-HFD group, compared with F-HFD group. The C-HFD group also displayed increased gene expression of inflammatory markers including Tumor necrosis factor alpha (Tnfa), C-C motif chemokine ligand 2 (Ccl2), and Interleukin-12 (Il12), as well as a tendency for liver fibrosis. Conclusion: These findings suggest that the sucrose-free C-HFD feeding in mice induces gut dysbiosis which associates with liver inflammation, steatosis, glucose intolerance and insulin resistance. https://www.mdpi.com/2072-6643/16/12/1929?utm_source=dlvr.it&utm_medium=tumblr

[endrusmithreal]

Vinylidene Chloride Market Analysis: Prices, Index, Trend & Forecast by Procurement Resource

In the Asia Pacific region, sulphur dioxide prices were impacted by inadequate support from feedstock materials, with strong supply due to China's manufacturing resurgence. In the second quarter, while downstream industries improved, excess product availability maintained a bearish price trend.

Request for Real-Time Vinylidene Chloride Prices: https://www.procurementresource.com/resource-center/vinylidene-chloride-price-trends/pricerequest

In Europe, weak feedstock prices and oversupply in domestic markets led to a price decline in the first quarter, with stagnant end-user demand. The second quarter saw a similar trend, with reduced sulphur dioxide production and pessimism among traders due to persistent logistical challenges.

In North America, falling consumption, economic uncertainties, and weak performance in paper, textiles, and pulp sectors, compounded by feedstock issues, contributed to a declining price trend, accentuated by inflation and interest rate concerns in the second quarter.

Definition

Vinylidene chloride is a chemical compound with the molecular formula CH2=CCl2. It is a colorless, flammable gas at room temperature. This compound is highly reactive due to its unsaturated double bond, making it susceptible to polymerization. Vinylidene chloride is primarily used in the production of copolymers, particularly with vinyl chloride. The resulting copolymers have exceptional gas and moisture barrier properties, making them valuable in the packaging industry for food wraps and protective films for electronics. Vinylidene chloride is known for its resistance to chemical permeation and its role in coatings, adhesives, and fire-retardant materials, enhancing product stability and performance.

Key Details About the Vinylidene Chloride Price Trend:

Procurement Resource does an in-depth analysis of the price trend to bring forth the monthly, quarterly, half-yearly, and yearly information on vinylidene chloride price in its latest pricing dashboard. The detailed assessment deeply explores the facts about the product, price change over the weeks, months, and years, key players, industrial uses, and drivers propelling the market and price trends.

Each price record is linked to an easy-to-use graphing device dated back to 2014, which offers a series of functionalities; customization of price currencies and units and downloading of price information as Excel files that can be used offline.

The vinylidene chloride price forecast, including India Vinylidene chloride price, USA Vinylidene chloride price, pricing database, and analysis can prove valuable for procurement managers, directors, and decision-makers to build up their strongly backed-up strategic insights to attain progress and profitability in the business.

Industrial Uses Impacting the Vinylidene Chloride Price Trend:

Vinylidene chloride finds diverse industrial applications due to its unique properties. Its primary use lies in the production of copolymers, especially with vinyl chloride. These copolymers, such as Saran, exhibit exceptional gas and moisture barrier properties, making them invaluable in the packaging industry for food wraps and protective films for electronics.

Vinylidene chloride is also employed in the creation of coatings and adhesives, where its barrier properties and resistance to chemical permeation enhance product performance and stability. In addition, it is utilized in the manufacturing of fire-retardant materials, providing improved resistance to flames and heat. These properties make vinylidene chloride a valuable component in various industrial processes and applications.

Key Players:

Dow

Asahi Kasei

Solvay

Shandong XingLu Chemical

Juhua Group

Jiangsu Huatewei

Nantong Repair-air

About Us:

Procurement Resource offers in-depth research on product pricing and market insights for more than 500 chemicals, commodities, and utilities updated daily, weekly, monthly, and annually. It is a cost-effective, one-stop solution for all your market research requirements, irrespective of which part of the value chain you represent.

We have a team of highly experienced analysts who perform comprehensive research to deliver our clients the newest and most up-to-date market reports, cost models, price analysis, benchmarking, and category insights, which help in streamlining the procurement process for our clientele. Our team tracks the prices and production costs of a wide variety of goods and commodities, hence providing you with the latest and consistent data.

To get real-time facts and insights to help our customers, we work with a varied range of procurement teams across industries. At Procurement Resource, we support our clients with up-to-date and pioneering practices in the industry to understand procurement methods, supply chains, and industry trends so that they can build strategies to achieve maximum growth.

Contact Us:

Company Name: Procurement Resource Contact Person: Chris Byrd Email: sales@procurementresource.com Toll-Free Number: USA & Canada – Phone no: +1 307 363 1045 | UK – Phone no: +44 7537 132103 | Asia-Pacific (APAC) – Phone no: +91 1203185500 Address: 30 North Gould Street, Sheridan, WY 82801, USA

[tumimmtxpapers]

The role of p53 in anti-tumor immunity and response to immunotherapy

p53 is a transcription factor that regulates the expression of genes involved in tumor suppression. p53 mutations mediate tumorigenesis and occur in approximately 50% of human cancers. p53 regulates hundreds of target genes that induce various cell fates including apoptosis, cell cycle arrest, and DNA damage repair. p53 also plays an important role in anti-tumor immunity by regulating TRAIL, DR5, TLRs, Fas, PKR, ULBP1/2, and CCL2; T-cell inhibitory ligand PD-L1; pro-inflammatory cytokines;... http://dlvr.it/Sty0BW

[magnoliasinbloom]

Crash Course Love

Infinite thanks to @lcbeauchampoftarth​ and @anna-swims​ for being awesome betas. 

AO3 :: Previously

2: Morning [Jamie]

“Wake up!” a voice hissed in my ear.

Holy shit. My tongue felt as though it was covered in sock fuzz, and my eyes were glued together.  I reached up to rub them open and found my hand brushing against soft, curly hair.

I jerked my eyes open. What the fuck? I scrambled back against a headboard. Where am I?

“Where am I?” I croaked, and my head immediately retaliated. Pulsing, throbbing pain flared up everywhere.

“This is my flat. Care to tell me why you’re here?” Her voice. English accent. The Sassenach.

Claire. Sorcha. Light. From that pub. The one who was cheated on by her boyfriend. I recalled some dancing… and Patron. Lots of whisky and Patron. Fuuuuuuck.

“I… dinna ken?” I pinched the bridge of my nose with my fingers, trying to stop the pounding. My hand was rudely smacked away.

“What? Focus! Please, answer this. Are you… are you naked?” Claire’s voice was slightly panicked.

Mary, Mother, and Bride. Had I… did we…?

I wasn’t wearing a shirt, that much I could tell. I reached under the covers tentatively, trying to ascertain whether I was naked. Mercifully, my fingers brushed against the waistband of my boxer briefs.

“Uh, no. I’m dressed. Sort of.” I glanced down at my bare chest. My curly red-gold chest hair stood out starkly in the bright light of her bedroom. Clearly, something had gone down last night. Or someone.

“Shit. Thank you, Jesus H. Christ.” Claire was gathering the bed sheet around herself.

“Wait, are ye naked?”

The light from the window hit her from behind, burnishing her hair into a rich brown. A deep pink blush spread down from her face, across her chest. Was she naked? I could feel my cock stirring and I willed it into submission. Clearly, now was not the time.

“I’m wearing underwear too. You think we—”

“Fuck! I hope not!” I exclaimed. Immediately, her face turned red again, but this time I could tell it was in anger. Then, I realized what I’d said and how it sounded. Blunt again.

“Oh, sweet Bride, I mean, no’ that I… ye’re totally gorgeous, I would definitely want to—shite,” I groaned. Too much thinking for what little brain cells I had left.

“You definitely want to shite?” she asked, raising her eyebrows in mock confusion. At least she seemed mollified by my ranting apology.

“No, I mean, ye ken, not that I’m glad we didna do anything… but I wouldna take advantage of you, but it’s not…” I trailed off lamely.

Claire chuckled softly, shaking her head. “I get it. Sorry. I’m just a little sensitive on that point. Thanks to that arsehole. I, uh, I better get some clothes on.”

“Aye, me too.” I pushed the covers aside, trying to ignore the thumping in my head. I spotted my jeans heaped in a corner, so I pulled them on while I searched for my shirt. I found it, sniffed it. Quite rank. No helping matters now.

I noticed Claire still huddling in the sheet, and I stopped, looking at her. “What?”

“Um, would you mind giving me some privacy? I know we woke up together and all, but I still don’t feel comfortable flashing you.”

Now it was my turn to go red. “Aye, of course. I’ll just… put on some coffee or something.” As she turned away from me, still wrapped in the bed sheet, I caught a glimpse of a tattoo on her right shoulder. It looked like spiraling scrollwork, or flowery vines; it trailed across her shoulder blade and disappeared beneath the sheet covering her ivory skin.

Ifrinn.

I nearly tripped on my way out. My foot caught on something. I shook it off, noticing as I did that it was her bra. Mallaichte bas. I tossed it at her and shut the door behind me.

I looked around as I made my way to the kitchen. The furniture looked very thrift-store-esque, but comfortable. The colors were mismatched, but somehow they fit.

On the walls, there were many framed pictures and paintings. Some photographs were black and white, offset by colorful flowery art. I noticed a lot were missing, the bare spots on the walls and tables glaringly obvious. I wondered where they’d gone.

I couldn’t figure out her coffeemaker, and soon gave that up in favor of a glass of water instead. I called out to Claire who was still in her room. “Do you have aspirin?”

“Here.” Her quiet voice startled me as she came up behind me. She pressed two pills into my palm and pulled a bottle of water from the fridge for herself. “Jason, is it?”

“James. Jamie.” I swallowed them quickly. I could practically feel the water rehydrating my brain. I leaned against the counter while Claire rummaged for food.

“Well, Jamie, I have cereal and cereal,” she said, frowning at the expiration date on the milk carton. “This is still drinkable. I think.”

“Uh, no, thank ye.” This would be awkward enough without a morning-after breakfast. Or was it, technically, since there hadn’t been a… before? I shrugged at myself, quickly gulping down more water.

We sat down at the kitchen table while she tossed Weetabix into a bowl. I grinned at her cereal choice—a little tame for the tequila-drinking tattooed lass. Claire caught me looking at her and blushed.

“What?”

“Nothing. Just… never mind.” I clutched my glass and an awkward silence fell between us, the only sound the clinking of her spoon.

“So,” she finally spoke. She glanced at me and back at her cereal.

“Aye.” I pursed my lips and took a sip of water.

“What do you remember?”

“Mmmphm… tequila. Lots of it,” I grimaced, scratching my head.

“I think I remember… dancing? Did we dance?” she asked skeptically.

“We danced,” I said, nodding emphatically.

“Was I drunk by then? I can’t think of any other way that would have happened.”

“A bit. Ye were past tipsy then, but ye did manage to express certain reservations.”

“No shit.” She glared at her cereal bowl, then stood up to dump it in the bin.

“Och, well, maybe—” I began.

“What the fuck!” Claire exclaimed. She had tossed half the mushy mess inside the bin when she cried out. She picked up the trash bin and set it on the table. She reached in, scrunching her nose.

Claire pulled out a stack of pictures, burned and charred. They were drenched in milk and speckled with soggy cereal.

“Oh, I wondered why there were pictures missing from the walls.” I gestured toward the small living room.

“It’s Frank.” Her voice sounded flat, but I thought I heard a hint of sadness.

“Cheating arsehole Frank?” I asked, taking some of the pictures from her. They were pretty good; the angles, the lighting, it was all very original and artistic. Some featured both Claire and Frank together, laughing or kissing. Others were just him, pensive and brooding. Bloke looked slim and posh. I could probably take him in a fight, I reasoned.

Claire found an empty plastic lighter in the bin too. She frowned. “After we came here, I took these off the walls and you said—”

“That I would help ye—”

“—and we would take out the trash together,” we finished, catching each other’s eyes. I wondered if she regretted what we’d done with part of her memories, before Claire’s face broke out into a smile—the first real smile I’d seen on her face. It was luminous.

“Thanks.” She took the pictures I’d been holding and dumped them in the bin again.

“Anytime.”

[covid-safer-hotties]

Reference saved in our archive

Neurological complications, including encephalopathy and stroke, occur in a significant proportion of COVID-19 cases but viral protein is seldom detected in the brain parenchyma. To model this situation, we developed a novel low-inoculum K18-hACE2 mouse model of SARS-CoV-2 infection during which active viral replication was consistently seen in mouse lungs but not in the brain. We found that several mediators previously associated with encephalopathy in clinical samples were upregulated in the lung, including CCL2, and IL-6. In addition, several inflammatory mediations, including CCL4, IFNγ, IL-17A, were upregulated in the brain, associated with microglial reactivity. Parallel in vitro experiments demonstrated that the filtered supernatant from SARS-CoV-2 virion exposed brain endothelial cells induced activation of uninfected microglia. This model successfully recreates SARS-CoV-2 virus-associated para-infectious brain inflammation which can be used to study the pathophysiology of the neurological complications and the identification of potential immune targets for treatment.

[recoveritecompressionwearsblog]

Medical Grade Calf Compression Sleeves in Australia

Our Medical Grade Calf Compression Sleeves in Australia at Recoverite is a must have for muscle pain, post operative recovery, injury etc. Created using Quantum Compression Technology featuring compression class 2 (CCL2) 20-30 mmHg medical-grade compression fabric to maximise health and recovery benefits. If you are interested to shop Recoverite Compression Wear range in your retail outlet, contact us to learn more: www.recoveritecompression.com.au #RecoveriteCompression ❄️🔥

[voykhoacomvn]

Top 5 Vớ  Y  Khoa tốt  nhập khẩu từ Ý

Vớ Y Khoa đã trở thành điều bắt buộc đối với những bệnh nhân bị suy giãn tĩnh mạch, đặc biệt là chân. Lựa chọn vớ y khoa loại nào tốt nhất vẫn là thắc mắc của nhiều người. Kiểm tra các chủ đề sau ngay bây giờ

Vớ y tế là gì?

Vớ y khoa là loại tất có tác dụng phòng ngừa và hỗ trợ điều trị suy giãn tĩnh mạch bằng áp lực đặc biệt. Tất tạo áp lực từ trên xuống, thắt chặt ở mắt cá chân và thả lỏng ở đùi / đầu gối giúp đẩy máu từ chân về tim để tăng lưu thông máu.

Vớ y tế có 2 loại áp CCL1 và CCL2 phù hợp với mọi giai đoạn của bệnh. Các kiểu tất khác nhau (tất đùi hoặc tất đầu gối) được sử dụng tùy theo sở thích của người dùng. Ngoài ra, chất liệu của tất hoàn toàn mỏng mịn, không gây kích ứng da nên rất thoải mái và an toàn cho sức khỏe.

Xem thêm bài viết: Cách sử dụng và mang vớ y khoa-vớ giãn tĩnh mạch

Vớ y tế tốt nhất là gì?

Thị trường vớ y khoa tầm trung được bày bán tràn lan, điều này có những mặt lợi và hại đối với người dùng hiện nay. Có rất nhiều thương hiệu khác nhau để lựa chọn nhưng người dùng sẽ rất khó để cân nhắc về chất lượng và sản phẩm đảm bảo chính hãng.

Nói đến các dòng vớ y khoa khác nhau như Jobst và Duomed, Relaxsan cũng là một thương hiệu nổi tiếng đến từ Ý. Vớ y khoa Relaxsan là sản phẩm dựa trên tiêu chuẩn kỹ thuật thiết bị y tế tiên tiến của Ý và Châu Âu, sử dụng chất liệu vải tổng hợp cao cấp đảm bảo an toàn cho người sử dụng.

Top 5 vớ y khoa tốt nhất của thương hiệu Relaxsan

Vớ y khoa giãn tĩnh mạch M2170A

Vớ M2170A được thiết kế để tạo áp lực lên các đoạn khác nhau của chi dưới của bệnh nhân suy tĩnh mạch. Chúng chặt hơn gần mắt cá chân và lỏng hơn khi hướng lên trên. Chúng luôn ôm và đẩy máu qua tĩnh mạch chân về tim. M2170A là mẫu tất trị liệu đùi và hở ngón của RelaxSan bằng chất liệu sợi siêu mịn nghệ thuật mềm mại. M2170 áp suất sock 23-32 mmHg Ưu điểm của sản phẩm: -Hỗ trợ suy tĩnh mạch mãn tính nhẹ, viêm tắc tĩnh mạch hoặc giãn tĩnh mạch sau phẫu thuật Kẹp cố định gót chân và các ngón chân sẽ không gây trơn trượt trong quá trình mang - Được may bằng chất liệu microfiber mềm mại mang lại cảm giác thoải mái và luôn thoáng khí đảm bảo không gây kích ứng da - Phù hợp với tiêu chuẩn CE của Tổ chức Y tế Thế giới -Sản xuất với công nghệ tiên tiến và chất lượng cao. sản xuất tại Ý.

Vớ điều trị giãn tĩnh mạch, hình dạng đùi, hở ngón chân loại II-sợi nhỏ mềm Art.M2170

Vớ điều trị giãn tĩnh mạch, hình dạng đùi, hở ngón chân loại II-sợi nhỏ mềm Art.M2170

Vớ y tế để ngăn ngừa chứng giãn tĩnh mạch Art.960A

Đây là loại tất phù hợp với những người có nguy cơ bị suy giãn tĩnh mạch hoặc những người có tình trạng nhẹ. Mặc nó có thể ngăn tình trạng trở nên tồi tệ hơn. Đánh giá áp suất 22-27mmHG

Ưu điểm của vớ Art.960A: - Thuộc dòng sản phẩm của thương hiệu nổi tiếng thế giới RelaxSan® Medicale Soft -Sản xuất tại Ý với công nghệ mới của Relaxsan -Thiết kế liền mạch không bị rối, không đường may hay bị cong khi mang -Chất vải siêu mịn không hầm bí, co giãn, thoáng mát và chống viêm nhiễm. Dễ dàng sử dụng trong thời gian dài -Khách hàng có thể yên tâm vì sản phẩm có chất lượng tốt và phù hợp với tiêu chuẩn CE

Ngừa giãn tĩnh mạch, dáng đùi, bít tất y khoa hở ngón-basic-Art.960A

Vớ y khoa điều trị suy giãn tĩnh mạch M2150A

Vớ có thể làm giảm lưu lượng máu, tăng tốc độ dòng máu tĩnh mạch sâu và giảm áp lực tĩnh mạch khi đi bộ, và ngăn ngừa huyết khối tĩnh mạch sâu. Microfiber soft-Art.M2150 có mức áp suất 23-32mmHg

Lợi thế

-Có đai mềm ở mép tất, không bị tuột khi mang -Cung cấp cho người dùng sự thoải mái tốt nhất -Công nghệ may một mảnh, bền -Vớ điều trị suy giãn tĩnh mạch hiệu Relaxsan-Italy, chất lượng tiêu chuẩn CE

Vớ y tế loại II đầu gối và hở ngón-sợi nhỏ mềm-Art.M2150A

Bây giờ hãy xem: câu trả lời-tác dụng của tất y tế trong việc điều trị chứng suy giãn tĩnh mạch ở chân

Vớ y khoa giãn tĩnh mạch M2050A

Tất chân hở ngón trên đầu gối với áp lực 23-32 mmHg có thể ngăn ngừa hiệu quả huyết khối và tắc mạch khi mang thai, suy tĩnh mạch mãn tính nhẹ, viêm tắc tĩnh mạch và giãn tĩnh mạch.

Ưu điểm của vớ M2050A: Chất liệu vải sợi nguyên chất mang đến sự thoải mái và độ bền lâu nhất cho người mặc. -Không có đường may lỏng lẻo ở tất cả các chi tiết -Dây thun không để lại vết hằn trên bàn chân, cũng như không tạo cảm giác bó chặt ngón chân và gót chân - Cố định ở các đầu ngón chân và gót chân, đàn hồi và mềm mại, mang lại cảm giác êm dịu giúp lưu thông máu -Art.M2050A cotton sản xuất theo tiêu chuẩn thiết bị y tế Châu Âu và chứng nhận EC

[moleculardepot]

Recombinant Human MCP-1 Protein

Recombinant Human MCP-1 Protein Catalog number: B2016065 Lot number: Batch Dependent Expiration Date: Batch dependent Amount: 10 μg Molecular Weight or Concentration: 12-14 kDa Supplied as: Lyophilized Applications: a molecular tool for various biochemical applications Storage: -20°C Keywords: MCP-1,C-C motif chemokine ligand 2, Monocyte Secretory Protein JE, CCL2, GDCF-2, HC11, HSMCR30, MCAF,…

[mohit-trendster]

कल-परसो मैंने पूछा था कि इस CCL 2 में कौनसे मैच को अपसेट का दर्जा दिया जा सकता है। उस थ्रेड में, 37 में से 7 मुकाबले इस श्रेणी में बताए गए। यानी लगभग 19 प्रतिशत मुकाबलों में ऐसा कहा गया कि जिस किरदार को जीतना चाहिए था वह हार गया। इन मुकाबलों के आकलन में, मैं 4 मैच को "upset" की श्रेणी में रख सकता हूं। यह मेरा मत है, शायद आपके मत से अलग हो। हालांकि, अगर सभी 7 मुकाबलों को अपसेट मान भी लिया जाए, तो भी ये संख्या पिछले सीज़न की तुलना में कम है। #CCL2 #comicscharacterleague

[rnomics]

Nutrients, Vol. 15, Pages 4397: Tributyrin Mitigates Ethanol-Induced Lysine Acetylation of Histone-H3 and p65-NFκB Downregulating CCL2 Expression and Consequent Liver Inflammation and Injury

Purpose: Chemokine-driven leukocyte infiltration and sustained inflammation contribute to alcohol-associated liver disease (ALD). Elevated hepatic CCL2 expression, seen in ALD, is associated with disease severity. However, mechanisms of CCL2 regulation are not completely elucidated. Post-translational modifications (PTMs) of proteins, particularly acetylation, modulate gene expression. This study examined the acetylation changes of promoter-associated histone-H3 and key transcription factor-NF&kappa;B in regulating hepatic CCL2 expression and subsequent inflammation and injury. Further, the effect of therapeutic modulation of the acetylation state by tributyrin (TB), a butyrate prodrug, was assessed. Methods: Hepatic CCL2 expression was assessed in mice fed control (PF) or an ethanol-containing Lieber&ndash;DeCarli (5% v/v, EF) diet for 7 weeks with or without oral administration of tributyrin (TB, 2 g/kg, 5 days/week). A chromatin immunoprecipitation (ChIP) assay evaluated promoter-associated modifications. Nuclear association between SIRT1, p300, and NF&kappa;B-p65 and acetylation changes of p65 were determined using immunoprecipitation and Western blot analyses. A Student&rsquo;s t-test and one-way ANOVA determined the significance. Results: Ethanol significantly increased promoter-associated histone-H3-lysine-9 acetylation (H3K9Ac), reflecting a transcriptionally permissive state with a resultant increase in hepatic CCL2 #mRNA and protein expression. Moreover, increased lysine-310-acetylation of nuclear RelA/p65 decreased its association with SIRT1, a class III HDAC, but concomitantly increased with p300, a histone acetyltransferase. This further led to enhanced recruitment of NF-&kappa;B/p65 and #RNA polymerase-II to the CCL2 promoter. Oral TB administration prevented ethanol-associated acetylation changes, thus downregulating CCL2 expression, hepatic neutrophil infiltration, and inflammation/ injury. Conclusion: The modulation of a protein acetylation state via ethanol or TB mechanistically regulates hepatic CCL2 upregulation in ALD. https://www.mdpi.com/2072-6643/15/20/4397?utm_source=dlvr.it&utm_medium=tumblr

[tumimmtxpapers]

Liver sinusoidal endothelial cells orchestrate NK cell recruitment and activation in acute inflammatory liver injury

Liver sinusoidal endothelial cells (LSECs) rapidly clear lipopolysaccharide (LPS) from the bloodstream and establish intimate contact with immune cells. However, their role in regulating liver inflammation remains poorly understood. We show that LSECs modify their chemokine expression profile driven by LPS or interferon-γ (IFN-γ), resulting in the production of the myeloid- or lymphoid-attracting chemokines CCL2 and CXCL10, respectively, which accumulate in the serum of LPS-challenged animals.... http://dlvr.it/SsVH6l