#CRISPR versus NgAgo

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Nature Biotechnology looking at NgAgo paper amidst reproducibility concerns

Nature Biotechnology looking at NgAgo paper amidst reproducibility concerns

When potentially game changing new technologies are reported such as NgAgo gene editing, both scientists and the public get excited, but especially if such new reports stem from a single paper it is wise to take a cautious approach for a while. The key question is whether the new findings will turn out to be reproducible.

With the case of NgAgo specifically, the Nature Biotechnologypaper…

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Gaetan Burgio New Data & Theory on NgAgo versus CRISPR

Gaetan Burgio New Data & Theory on NgAgo versus CRISPR

By Gaetan Burgio

CRISPR/Cas9 genome editing has dramatically changed our way to perform biological experiments. While highly efficient and easy to use, one limitation with CRISPR/Cas9 mediated genome editing technology is the occurrence of off-target effects and the restriction of the PAM recognition sequence. Many modifications from the original system have been proposed to improve its…

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TGIF Science: funding, CRISPR v. NgAgo, secrets, Zika, & more

TGIF Science: funding, CRISPR v. NgAgo, secrets, Zika, & more

Some stuff on my mind for our TGIF Science this week.

Research Funding Ups: NIH. Is it my imagination or is NIH funding slightly improving? This is the overall vibe I’m hearing from the trenches.

Modified Wikipedia image

Research Funding Ups and Downs: CIRM. CIRM funded some basic research to the tune of a total of $4 million, which is great. On a personal level, just wish my “great idea” had…