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cancersfakianakis1 · 6 years

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Clinical outcomes for patients with Gleason Score 10 prostate adenocarcinoma: results from a multi-institutional consortium study

Publication date: Available online 5 April 2018 Source:International Journal of Radiation Oncology*Biology*Physics Author(s): Kiri A. Sandler, Ryan R. Cook, Jay P. Ciezki, Ashley E. Ross, Mark M. Pomerantz, Paul L. Nguyen, Talha Shaikh, Phuoc T. Tran, Richard G. Stock, Gregory S. Merrick, D. Jeffrey Demanes, Daniel E. Spratt, Eyad I. Abu-Isa, Trude B. Wedde, Wolfgang Lilleby, Daniel J. Krauss, Grace K. Shaw, Ridwan Alam, Chandana A. Reddy, Daniel Y. Song, Eric A. Klein, Andrew J. Stephenson, Jeffrey J. Tosoian, John V. Hegde, Sun Mi Yoo, Ryan Fiano, Anthony V. D’Amico, Nicholas G. Nickols, William J. Aronson, Ahmad Sadeghi, Stephen C. Greco, Curtiland Deville, Todd McNutt, Theodore L. DeWeese, Robert E. Reiter, Jonathan W. Said, Michael L. Steinberg, Eric M. Horwitz, Patrick A. Kupelian, Christopher R. King, Amar U. Kishan BackgroundGleason score (GS) 10 disease is the most aggressive form of clinically localized prostate adenocarcinoma (PCa). The long-term clinical outcomes and overall prognosis for patients presenting with GS 10 PCa are largely unknown due to its rarity.Methods112 patients with biopsy GS 10 PCa who received treatment with radical prostatectomy (RP, n=26), external beam radiotherapy (EBRT, n=48), and EBRT with a brachytherapy boost (EBRT+BT, n=38) between 2000-2013 were included. Propensity scores were included as covariates for comparative analysis. Overall survival (OS), prostate cancer-specific survival (PCSS), and distant metastasis-free survival (DMFS) were estimated using the Kaplan-Meier method with inverse probability of treatment weighting to control for confounding.ResultsThe median follow-up was 4.9 years overall (3.9 for RP, 4.8 for EBRT, and 5.7 for EBRT+BT). Significantly more EBRT than EBRT+BT patients received upfront ADT (98% vs 79%, p<0.01 by Chi square), though durations were similar (median 24 and 22.5 months, respectively). Thirty-four percent of RP patients received postoperative EBRT, and 35% received neoadjuvant systemic therapy. Propensity score-adjusted 5-year OS was 80% for the RP group, 73% for the EBRT group, and 83% for EBRT+BT group. Corresponding adjusted 5-year PCSS rates were 87%, 75%, and 94%, respectively. EBRT+BT trended toward superior DMFS when compared with RP (HR 0.3, 95% CI 0.1-1.06, p = .06) and had superior DMFS when compared with EBRT (HR 0.4, 95% CI 0.1-0.99, p = .048).ConclusionsTo our knowledge, this is the largest series ever reported on the clinical outcomes of patients with biopsy GS 10 PCa. These data provide useful prognostic benchmark information for physicians and patients. Aggressive therapy with curative intent is warranted, as >50% of patients remain free of systemic disease five years following treatment.

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Gleason 10 prostate cancer is extremely aggressive, and clinical outcomes are largely unknown due to its rarity. This study provides benchmark clinical outcomes information for patients with Gleason 10 prostate cancer with data extracted from a large multi-institutional database. Though it follows an aggressive course, the majority of patients are free from disease at 5 years, and there may be benefits to treating with radiation and brachytherapy. https://ift.tt/2HgfThd

#Oncology-Sfakianakis

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videotelegram · 7 years

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Poem by Christopher DeWeese‏ @chris_deweese

#new years eve

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dunkelwort · 7 years

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RAUM - Vol 1 Issue 4

RAUM – Vol 1 Issue 4

New poetry from Scotland and beyond: Catherine Baird // Bob Beagrie // Jelle Cauwenberghs // Anthony Daly // Christopher DeWeese // Federico Federici // R.M. Francis // Franklin Gilette // Jane Goldman // Mark Goodwin // Chris Hardy // Peter J. King // Fiona Tinwei Lam // Joan Lennon // Aoife Lyall // Declan Malone // Heather O’Donnell // Pratyusha Prakash// Carolyn Richardson // Lindsey Shields…

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#poetry #raum

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georgiapioneers · 7 years

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Caswell Co. NC Genealogies and Histories #northcarolinapioneers

Caswell County Wills and Estates

1777 to 1783

1783 to 1791

1792 to 1800

Taxable Property

1783 (Inhabitants)

1787 to 1789

1790 (and Fines)

1792 to 1793

1794 (and Accounting)

1795

1797

Accountings of Estates

Oct 1796 Court

Jan and July 1799 Court

Jan and July 1800 Court

Miscellaneous Records

Caswell County Deeds (trancribed)

Browning, John, 1782 deed from the State of North Carolina Plat of Yanceyville (1839)

Find your Ancestors Records on North Carolina Pioneers SUBSCRIBE HERE

via Blogger http://ift.tt/2jdSQZy

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char27martin · 7 years

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Ellen Birkett Morris: Poet Interview

Please join me in welcoming Ellen Birkett Morris to the Poetic Asides blog!

Ellen Birkett Morris

Ellen Birkett Morris is the author of Surrender, a poetry chapbook. Her fiction, poetry, essays, reviews and interviews have appeared in journals including Antioch Review, Ploughshares, Prairie Schooner, wigleaf, Inscape, The Butter, and Shenandoah.

She is a recipient of a 2013 Al Smith Fellowship from the Kentucky Arts Council.

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Forget Revision, Learn How to Re-create Your Poems!

Do you find first drafts the easy part and revision kind of intimidating? If so, you’re not alone, and it’s common for writers to think the revision process is boring–but it doesn’t have to be!

In the 48-minute tutorial Re-Creating Poetry: How to Revise Poems, poets will learn how to go about re-creating their poems with the use of 7 revision filters that can help poets more effectively play with their poems after the first draft. Plus, it helps poets see how they make revision–gasp–fun!

Click to continue.

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What are you currently up to?

I am currently shopping a novel around to agents. I have three agents reading the full manuscript, and I am hoping one of them falls in love with it enough to want to fight for it in the marketplace. I just finished teaching a class on turning life experience into poetry through The Loft Literary Center, where I was impressed by the range of talent I saw. I’m writing short stories, poems and essays and when they are finished sending them to literary journals. My most recent poem is in the current issue of 3Elements Review and is titled “One Woman’s Yard Sale Is Another Woman’s Temple.” I also have an essay coming out in The Common’s Dispatches column on August 30.

How did Surrender come together as a collection?

I wrote a series of poems throughout my forties that dealt with the stuff that happens when you are that age, like losing a parent and pet and being in a mature, loving relationship. When I had enough poems and I looked at them together it occurred to me that growing older successfully requires a certain amount of surrendering to your circumstance. I saw the theme of surrender running through the poems and knew the poems could work as a collection.

Were there any surprises in the publishing process?

I think that unpublished authors dream of publication and anticipate a level of interest in their work that might match that of a more widely published author. I was in a workshop with the writer Ron Carlson and he told all the writers, “There is no mandate for your work.” What he meant was that the world was not waiting for their work.

I had a great group of supportive friends who filled the bookstore when my book came out. It was fantastic, but I tempered my expectations when it came to the general public. Luckily, I got a good review in my hometown paper and there was some word of mouth so there were additional sales. I think it helps to work hard, spread the word and try to keep your expectations in check.

Have you done anything to promote the book since publication?

I sent out a press release and made sure the local book page editor had a copy of the book. I participated in local writing conferences and read at all the major reading series in Louisville. I did an interview with a local community radio station and participated in a podcast about writing.

You write and publish fiction, poetry, and essays. Are their cues that help you decide whether a particular subject should be a poem versus a story or essay?

I think topics that have a strong visual associated with them or a clear contrast call out to be poems. In poetry a simple image can represent so much. I could have written about my the pain of watching my father diminished as he grew sicker and the depth of our parent/child relationship in an essay, but my poem “Hollow Bones” says all that more powerfully and gracefully in fewer words.

Hollow Bones

Crows have hollow bones Elegant scaffolding designed for flight Had you hollow bones I could lift you from your bed Carry you outside to feel the sun See the clouds drift across the sky Watch the shadows lengthen

But you fall into a darkness I cannot penetrate Your bones riddled with tiny holes Like a fossil found on the river bottom By a small boy who shouts to his father To announce his find As a crow soars overhead

You teach creative writing courses at The Loft Literary Center in Minneapolis and The Carnegie Center for Literacy and Learning in Lexington. Could you share one or two things you often try to communicate to your students?

I talk about the importance of finding the right kind of details to bring a piece alive – something unusual, vivid and particular that will provide insight into the character or situation and set the story or poem apart from all the other stories and poems that come through the slush pile.

I talk about believing in yourself as a writer, working hard, educating yourself, and being fearless in the face of rejection.

One poet more people should know: Who is it?

I really like the work of Christopher DeWeese, whose second poetry collection, The Father of the Arrow is the Thought, came out fairly recently. He taught at the Antioch Writers Workshop the year I attended and was a fantastic teacher.

If you could pass along only one piece of advice for other poets, what would it be?

Look around, set down your phone and let the world in, find the thing that stands for another thing and you will have the makings of a poem.

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Robert Lee Brewer is the editor of Poet’s Market and author of Solving the World’s Problems. Follow him on Twitter @robertleebrewer.

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Check out these other poetic posts:

John Sibley Williams: Poet Interview.

20 Best Tips for Poets.

11 French Poetic Forms.

The post Ellen Birkett Morris: Poet Interview appeared first on WritersDigest.com.

from Writing Editor Blogs – WritersDigest.com http://www.writersdigest.com/whats-new/ellen-birkett-morris-poet-interview

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