#Global Reperfusion Treatment Market

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Fibrinolytic Therapy Market will grow at highest pace owing to increasing occurrence of heart attacks and strokes

The fibrinolytic therapy market comprises drugs that help dissolve or break down blood clots or fibrin. Fibrinolytic drugs or thrombolytic drugs are administered to heart attack or stroke patients during the initial hours of events to restore blood flow by dissolving clots. Fibrinolytic therapy drugs help minimize heart muscle damage during a heart attack and reduce complications from strokes. Some of the commonly used fibrinolytic drugs include alteplase, reteplase, and tenecteplase. These drugs have shown to minimize long-term disability from strokes and help reduce mortality rates associated with heart attacks. The increasing prevalence of cardiovascular diseases such as strokes and heart attacks has augmented the demand for fibrinolytic drugs globally. The Global fibrinolytic therapy market is estimated to be valued at US$ 34.96 billion in 2024 and is expected to exhibit a CAGR of 3.7% over the forecast period 2023 to 2030. Key Takeaways Key players operating in the fibrinolytic therapy market are Genentech, Inc. (Roche), Bayer AG, Boehringer Ingelheim International GmbH, Pfizer Inc., Bristol Myers Squibb Company, Novartis AG, AstraZeneca PLC, Johnson & Johnson, Daiichi Sankyo Company, Limited, Merck & Co., Inc., Sanofi S.A., Takeda Pharmaceutical Company Limited, Abbott Laboratories, Mallinckrodt Pharmaceuticals, Mitsubishi Tanabe Pharma Corporation. The major players are focusing on expanding their product portfolio and market presence through mergers and acquisitions. For instance, in October 2021, Bristol Myers Squibb acquired Synthorx for $2.5 billion to expand its oncology pipeline. The rising incidences of heart attacks and strokes globally have propelled the demand for fibrinolytic drugs. According to the World Health Organization, cardiovascular diseases account for over 17 million deaths annually, which is expected to increase to over 23 million by 2030. Factors such as the growing geriatric population, increasing prevalence of risk factors like obesity, diabetes and hypertension have augmented the cases of heart attacks and strokes significantly. Technological advancements have expanded the therapeutic applications of fibrinolytic drugs. Several biopharmaceutical companies are developing injectable and aspiration formulations of existing fibrinolytic drugs for expanding treatment options. The development of novel recombinant fibrinolytic therapies with targeted clot specificity, faster onset of action and improved safety profiles is expected to revolutionize the treatment of strokes and heart attacks. Market Trends Increased Research Focus on Expanding Treatment Window: Major pharmaceutical companies are conducting clinical trials to evaluate the potential of fibrinolytic drugs in expanding the treatment window for strokes and heart attacks beyond the current narrow window of 4.5 hours. Successful trials demonstrating safety and efficacy in later treatment windows can significantly increase the eligible patient population. Growing Adoption of Combination Therapies: Combining fibrinolytic drugs with mechanical thrombectomy devices or antiplatelet drugs is gaining popularity for maximizing reperfusion rates and improving clinical outcomes compared to standalone fibrinolytic treatments. The sustained research on combination therapies is likely to boost the adoption of fibrinolytic drugs. Market Opportunities Emerging Countries: Emerging economies like India, China, Brazil, Mexico etc. present lucrative opportunities for fibrinolytic drug manufacturers due to the increasing healthcare investments, growing medical needs and rising affordability in these regions. Expanding Indications: Apart from cardiac and cerebral ischemia, ongoing research evaluating the effectiveness of fibrinolytic drugs in pulmonary embolism, deep vein thrombosis and peripheral arterial disease can potentially create new revenue streams over the forecast period.

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REPERFUSION TREATMENT MARKET ANALYSIS(2020-2027)

Reperfusion Treatment Market, by Treatment Type (Therapeutic Hypothermia, Cyclosporin, Stem Cell Therapy, Hydrogen Sulphide Treatment, and Others), by Injury Type (Heart Injury, Kidney Injury, Intestine Injury, and Others), by Distribution Channel (Hospital Pharmacies, Retail Pharmacies, and Others), and by Region (North America, Latin America, Europe, Asia Pacific, Middle East, and Africa) - Size, Share, Outlook, and Opportunity Analysis, 2020 - 2027

Reperfusion injury is caused due to the damage in the tissue, which occurs due to the lack of blood supply. Examples of reperfusion injury include brain damage after stroke and many others, where reperfusion therapy leads to flow of blood in the tissue which results in inflammation and oxidative damage due to oxidative stress. Reperfusion injury can be treated by therapeutic hypothermia, hydrogen sulphide treatment, cyclosporins, stem cell therapy, and others. Furthermore, delay in reperfusion therapy results in oxidative damage.

Global Reperfusion Treatment Market – Impact of Coronavirus (COVID – 19) Pandemic:

The COVID-19 pandemic is expected to hamper the global reperfusion treatment market growth during the forecast period. The COVID-19 pandemic and resulting lockdowns in various countries across the globe have impacted the financial status of businesses in all sectors. The private healthcare sector has been impacted majorly due to the COVID-19 pandemic. Many clinical trials have been suspended during the pandemic. In order to restart the clinical trials, the U.S. Food and Drug Administration (FDA) released guidelines during the COVID-19 public health emergency in March 2020. The guidelines were further updated on July 02, 2020. The guidelines include general considerations to assist sponsors and researchers, which ensure the safety of trial participants, and compliance with good clinical practice (GCP) for the duration of the COVID-19 public health emergency. The appendix of the guidelines also provide answers to some general questions, which the U.S. Food and Drug Administration (FDA) received from various sponsors and researchers about conducting clinical trials during the COVID-19 public health emergency. The above guidelines are also applicable for conducting the clinical trials for testing the safety and efficacy of the drugs for the reperfusion injury. Thus, the COVID – 19 pandemic is expected to decrease the growth of the reperfusion treatment market over the forecast period.

The global reperfusion treatment market is estimated to be valued at US$ 1,293.6 million in 2020 and is expected to exhibit a CAGR of 4.5% during the forecast period (2020-2027).

Figure 1: Global Reperfusion Treatment Market Share (%) Analysis, By Treatment Type 2020

Increasing prevalence of coronary heart dis ease is expected to drive the growth of the global reperfusion treatment market during the forecast period.

The rising incidence of coronary artery disease (CAD) or ischemic heart disease (IHD) is a major factor which is expected to drive the market growth. The CAD or IHD is caused due to the buildup of cholesterol and fatty deposits on the inner walls of the arteries, which may lead to the reduction of blood flow to the heart cells. This condition may lead to ischemia, myocardial infraction or sudden cardiac arrest. Moreover, medicines approved from the regulatory authorities are not available in the market for the treatment of ischemia/reperfusion injury. According to the National Center for Biotechnology Information (NCBI), 2020, in 2017, globally, around 126 million people suffered from ischemic heart disease (1,655 per 100,000), which constituted to 1.72% of the total world population.

Investments and expansion of production facility by market players are expected to boost growth of the global reperfusion treatment market during the forecast period.

Market players are focusing on facility expansions in order to strengthen their product portfolio. For instance, on March 9, 2020, Pharming Group NV received the Food and Drug Administration (U.S. FDA) approval for its new production facility in the Netherlands for the production of the starting material required for manufacturing of RUCONEST. RUCONEST is a C1-esterase inhibitor, which is plasma free and is proven to help treat hereditary angioedema (HAE) attacks. Furthermore, on January 21, 2020, Pharming Group NV received the European Medicines Agency (EMA) approval for the production facility for RUCONEST in Europe.

Global Reperfusion Treatment Market – Restraints:

There are some side effects associated with the treatment, which are expected to restrain the global reperfusion treatment market during the forecast period. Ischemia reperfusion causes the mediator to infiltrate other tissues, which leads to Multiple Organ Dysfunction Syndrome (MODS). For instance, according to an article published in the International Institute of Anticancer Research in 2019, Multiple Organ Dysfunction Syndrome (MODS) was the leading cause of mortality globally and the incidence of MODS ranged from 25-40%. Furthermore, according to the Critical Care Nephrology Journal 2019, the pediatric multiple organ dysfunction syndrome (MODS) epidemiology ranges from 10% to 50% of the children admitted to the pediatric intensive care unit.

Global Reperfusion Treatment Market – Regional Analysis:

On the basis of region, the global reperfusion treatment market is segmented into North America, Latin America, Europe, Asia Pacific, Middle East, and Africa.

North America is expected to dominate the global reperfusion treatment market during the forecast period owing to research and development in the region. For instance, in November 2019, Faraday Pharmaceuticals announced positive results from phase II clinical trials of FDY-5301 for ischemia reperfusion injury treatment, following a STEMI heart attack. FDY-5301 is a formulated, patented, elemental reducing agent that contains sodium iodide. It destroys the hydrogen peroxide that is naturally generated as a response to acute ischemia reperfusion injury and also contributes to loss of muscle function and mass.

Europe is an emerging reperfusion treatment market owing to the funding provided for research and development by regulatory authorities. For instance, in February 2019, Balmes Transplantation SAS received around US$ 605,597 million from the European Regional Development Fund (ERDF) for its research program REMEDIRA for developing combinations of repurposed drugs against kidney ischemia-reperfusion injury (IRI).

 Figure 2: Global Reperfusion Treatment Market Value (US$ Mn), by Region, 2020

Global Reperfusion Treatment Market - Competitive Landscape:

Some of the key players operating in the global reperfusion treatment market are Corline Biomedical AB, SBI Holdings Inc., Pharming Group NV, Mallinckrodt Pharmaceuticals, MIFCOR, Inc., CFM Pharma Holding B.V., Balmes Transplantation SAS, Revive Therapeutics Ltd., Faraday Pharmaceuticals, Radikal Therapeutics Inc., Amyndas Pharmaceuticals, Perfusion.com, Inc., Angion Biomedica Corp., Young Therapeutics, LLC, Ischemix, Stealth Biotherapeutics Inc., and Bolder Bio Technology Inc.

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Organ Preservation Market Value to Cross $ 455 Mn in 2032

According to a new analysis from FMI, the Organ Preservation Market is likely to reach US$ 455 Million in revenue by 2032, from US$ 230 Million in 2021, registering a strong 6.4% CAGR during the forecast period.

The rising incidence of chronic illnesses has a direct impact on the adoption of organ preservation, according to the findings of this study. The practice of conserving healthy organs removed from donors’ bodies is known as organ preservation. Organs are removed from the donor’s body, stored for transit, and then transplanted into the recipient’s body without causing major damage. Donor organ quality is strongly influenced by organ preservation for transplantation, which has a direct impact on a patient’s morbidity and survival rates following transplantation. One of the important reasons driving the organ preservation solutions market growth is the rising incidence of chronic illnesses, as well as the growing elderly population throughout the world.

Static cold storage organ preservation treatments are becoming more common as a result of the rising number of organ failures caused by diabetes, cardiovascular illnesses (CVDs), obesity, and other serious medical problems. Innovative and sophisticated strategies for organ preservation, such as NMP, are working as a growth-inducing agent.

Such strategies help to reduce the risk of reperfusion damage following transplantation and enhance static cold storage organ preservation results in clinical and experimental research. Furthermore, a growing number of government and non-government regulations and activities to encourage organ donation are favorably boosting the organ preservation solutions market growth.

The market is also being pushed forward by the growing number of people who volunteer to donate their organs for transplantation and research. Other factors such as increased research and development (R&D) as well as substantial developments in the global organ preservation market are expected to considerably contribute to market expansion.

Key Takeaways:

When the liver is no longer functioning, a preservation injury liver transplantation, also known as a hepatic transplant, can potentially preserve a person’s life. A doctor may also recommend a liver transplant to a patient who has reached the final stage of liver disease.

American Journal of Transplantation article, individuals who have a liver transplant had an 89% likelihood of survival after one year. The increasing need for organ transplantation is driving the global organ preservation market throughout the area.

Around 114,000 people in the United States are now on the waiting list for a life-saving organ transplant, according to the American Transplant Foundation. Each day, on average, 20 individuals die due to a scarcity of accessible organs for transplantation.

Competitive Landscape:

The global organ preservation marketis dominated by companies such as Paragonix Technologies (US), XVIVO Perfusion AB (Sweden), Dr Franz Köhler Chemie GmbH (Germany), Essential Pharmaceuticals, LLC (US), TransMedics (US), OrganOx Limited (UK), 21st Century Medicine (US), Bridge to Life Limited (US), Waters Medical Systems (US), Preservation Solutions (US), Carnamedica (Poland), Transplant Biomedicals (Spain), Institut (Netherlands).

Key Market Segmentation Covered:

By Solution:

University of Wisconsin Solution (UW Solution)

Custodial HTK

Perfadex

Other Solutions

By Technique:

Static Cold Storage

Hypothermia Machine Perfusion

Normothermic Machine Perfusion

By Organ Type:

Kidney

Liver

Long

Heart

Pancreas

By End User:

Organ Transplant Centres

Hospitals

Speciality Clinics

By Region:

North America

Latin America

Europe

Asia Pacific

Middle East and Africa (MEA)

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[ganeshg]

Organ Preservation Market Is Set to Experience a Significant Growth Of 6.4% CAGR From 2022 To 2032

According to a new analysis from FMI, the Organ Preservation Market is likely to reach US$ 455 Million in revenue by 2032, from US$ 230 Million in 2021, registering a strong robust of 6.4% CAGR during the forecast period. The rising incidence of chronic illnesses has a direct impact on the adoption of organ preservation, according to the findings of this study.

The practice of conserving healthy organs removed from donors' bodies is known as organ preservation. Organs are removed from the donor's body, stored for transit, and then transplanted into the recipient's body without causing major damage.

Donor organ quality is strongly influenced by organ preservation for transplantation, which has a direct impact on a patient's morbidity and survival rates following transplantation. One of the important reasons driving the organ preservation solutions market growth is the rising incidence of chronic illnesses, as well as the growing elderly population throughout the world.

 Static cold storage organ preservation treatments are becoming more common as a result of the rising number of organ failures caused by diabetes, cardiovascular illnesses (CVDs), obesity, and other serious medical problems. Innovative and sophisticated strategies for organ preservation, such as NMP, are working as a growth-inducing agent.

Such strategies help to reduce the risk of reperfusion damage following transplantation and enhance static cold storage organ preservation results in clinical and experimental research. Furthermore, a growing number of government and non-government regulations and activities to encourage organ donation are favorably boosting the organ preservation solutions market growth.

The market is also being pushed forward by the growing number of people who volunteer to donate their organs for transplantation and research. Other factors such as increased research and development (R&D) as well as substantial developments in the global organ preservation market are expected to considerably contribute to market expansion.

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Key Takeaways:

● When the liver is no longer functioning, a preservation injury liver transplantation, also known as a hepatic transplant, can potentially preserve a person's life. A doctor may also recommend a liver transplant to a patient who has reached the final stage of liver disease.

● American Journal of Transplantation article, individuals who have a liver transplant had an 89% likelihood of survival after one year. The increasing need for organ transplantation is driving the global organ preservation market throughout the area.

● Around 114,000 people in the United States are now on the waiting list for a life-saving organ transplant, according to the American Transplant Foundation. Each day, on average, 20 individuals die due to a scarcity of accessible organs for transplantation.

Competitive Landscape

The global organ preservation market is dominated by companies such as Paragonix Technologies (US), XVIVO Perfusion AB (Sweden), Dr Franz Köhler Chemie GmbH (Germany), Essential Pharmaceuticals, LLC (US), TransMedics (US), OrganOx Limited (UK), 21st Century Medicine (US), Bridge to Life Limited (US), Waters Medical Systems (US), Preservation Solutions (US), Carnamedica (Poland), Transplant Biomedicals (Spain), Institut (Netherlands).

● Paragonix Technologies will commercialize the LIVERguard Donor Liver Preservation System in the United States and Europe in 2021. This strategy increased the product options and geographic reach of Paragonix.

● In 2021, XVIVO Perfusion teamed with Contatti Medical (Brazil) to develop its company and have access to the largest network of transplantation clinics in Latin America, Brazil.

● Institut Georges Lopez (Igl) (France) increased its presence in India in 2021 by establishing a manufacturing plant in Cheyyar, Tamil Nadu, for the manufacture of medical equipment and treatments for organ preservation for transplantation.

● Transmedics gained premarket approval from the FDA in 2021 for the OCS Heart System, which is intended for use with organs donated after brain death (DBD).

● Dr Franz Köhler Chemie GmbH (Germany) engaged in a joint venture with Melchers Group and CICEL (Germany) in 2020 to create Köhler Pharmaceuticals (Beijing) Ltd. in China to distribute Custodiol HTK solutions for heart and transplant operations in the Chinese market.

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Clot Management Devices Market Trend, Forecast, Drivers, Restraints, Company Profiles and Analysis by 2027

The rising prevalence of peripheral artery disease, increase in the prevalence of coronary heart disease and renal disease, increase in healthcare awareness, and rise in the geriatric population are the primary factors driving the growth of the clot management devices market. 

Furthermore, anticoagulant therapy is the first line of treatment for deep vein thrombosis, which limits market growth. However, the market for clot management devices is projected to face hurdles due to the complicated technique of device handling. The current trend in the Global Clot Management Devices Market is the combined use of percutaneous thrombectomy and catheter guided thrombolysis for the treatment of acute venous thrombosis.

The clot management devices market is predicted to develop due to the introduction of revolutionary next-generation thrombectomy devices such as Penumbra's AC68 reperfusion catheter and quick technical advancements. 

Furthermore, market expansion is fueled by key companies' ongoing R&D investments, improvements in patient health outcomes, and rising demand for cost-effective technologies. However, the industry is projected to be constrained by a lack of educated physicians and payments in poorer nations. By removing blood clots from arteries, clot management devices can help prevent ischemic strokes, severe limb pain, and heart attacks.

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[healthcare-market]

Neurovascular Devices Market size Growth to be Benefited by Technological Advancements

Global Neurovascular Devices Market: Overview

The global population is aging rapidly. According to WHO, the chances of health risks are greater in geriatric people than the young generation. Old age is considered to be one of the biggest risk factors that are responsible for developing various diseases such as cardiovascular and neurological conditions. It is because of these factors, the global neurovascular devices market is experiencing robust growth in the forecast period of 2018 to 2026. Moreover, various favorable government regulations such as Family Smoking Prevention and Tobacco Control Act, that allows FDA with the power to control production, marketing and use of tobacco products, are another factors that are promoting the growth of global neurovascular devices market over the period of time.

Transparency Market Research provides a consolidated report on global neurovascular devices market. It encapsulates the various facets that can be insightful for the players who are willing to step in and grow in the market. The report enlightens developments, opportunities, challenges and key drivers that are responsible for the growth of the global neurovascular devices market during the forecast period.

Global Neurovascular Devices Market: Notable Development

The consolidated global neurovascular devices market is influenced by the activities of players such as Stryker Corporation, Johnson & Johnson, Penumbra, Inc. Abbott Laboratories, and Merit Medical Systems, Inc. These players are adopting strategies such as mergers, partnerships, and collaborations in order to acquire a competitive edge over their rivals in the global neurovascular devices market.

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Some of the notable development of the market are as follows;

· In December 2016, Codman Neuro, Johnson & Johnson subsidiary took over Pulsar Vascular Inc. The acquisition was aimed at enhancing the product portfolio of the company for hemorrhagic and ischemic stroke.

· Terumo Corporation, Abbott Laboratories and St. Jude Medical Inc. signed an agreement in December 2016. According to the agreement, Terumo Corporation acquired St. Jude Medical’s Angio-Seal and FermoSeal Vascular closure product line along with Abbott’s Vado Steerable Sheath. With this agreement, the acquirer enhanced its portfolio in minimal invasive site management. It also strengthened the company’s visibility in U.S. neurovascular devices market.

· July 2016, marked the launch of ACE 68 Reperfusion Catheter by Penumbra, Inc. The product was launched for acute ischemic stroke treatment. The device includes the latest technologies that are designed to deliver aspiration power to its full strength so as to extract thrombus in acute ischemic stroke.

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These are the development that is influencing other players of global neurovascular devices market to invest heavily in research and development in order to compete with their rivals.

Global Neurovascular Devices Market: Key Drivers

With the launch of new and technologically advanced miniaturized neurovascular devices, the global neurovascular devices market is witnessing robust growth in the forecast period. Also, the commercialization of effective, easy-to-use, and technologically advanced neurovascular devices are influencing the growth of global neurovascular devices market in recent duration. Various developments in terms of technology, effectiveness, accuracy, and reduction in risk of traumas are one of the key factors that are promoting the growth of global neurovascular devices market.

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Moreover, various government bodies across multiple countries are proactively recognizing the benefits of neurosurgical and interventional neurology products. They are heavily accepting and acknowledging devices such as stents, coils, and flow diverters to offer better neurosurgical solutions to the people of their respective countries. Owing to these reasons, the global neurovascular devices market is expected to witness robust growth in the forecast period of 2018 to 2026.

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Global Neurovascular Devices Market: Regional Analysis

North America is accounted for the highest growth in the global neurovascular devices market during the forecast period. The growth of the region is attributed to the favorable reimbursement structure, especially in U.S. and extensive research and development investments along with a variety of product launches by neurosurgeons. Finally, the availability of various advanced technology to improve the efficiency and reliability of neurovascular devices is also a major factor for North America to lead other regions of global neurovascular devices market in the forecast period.

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Ischemia Reperfusion Injury Therapeutics Market Analysis (2020-2027)

Ischemic injury occurs due to the insufficient blood supply to the tissue. According to the National Institutes of Health, the burden of cardiovascular diseases (CVDs) such as stroke and myocardial infarction is increasing rapidly at a global level. This would, in turn, increase the number of patients with ischemia-reperfusion injury. The condition lowers the level of ATP production and thus inactivates ion-exchange channels. Ischemia reperfusion injury is a critical medical condition that poses a major therapeutic challenge for physicians. Key players in the market are involved in research and development of novel drugs and treatment which is expected to escalate the growth of the global ischemia reperfusion injury therapeutics market.

The rising number of tissue damage cases and the increasing awareness about ischemia reperfusion injury is expected to drive growth of the global ischemia reperfusion injury therapeutics market during the forecast period. Moreover, the increasing investments by key players in research & development of novel treatment for ischemia reperfusion are estimated to boost the market growth. For instance, in November 2018, Revive Therapeutics received the Orphan Drug designation for Cannabidiol from the U.S. Food and Drug Administration (FDA) to prevent ischemia reperfusion injury resulting from organ transplantation.

Global Ischemia Reperfusion Injury Therapeutics Market - Impact of Coronavirus (Covid-19) Pandemic

The global ischemia reperfusion therapeutics market growth has been affected by the COVID-19 pandemic as it has become difficult to conduct research in the current situation. Thus, several market players are focusing on strategies which can help patients with ischemic reperfusion injury to remain agile during the disruption of healthcare services. Moreover, several government organizations across the globe are implementing policies and regulations to deal with the current crisis.

The all-inclusive version of the report will include the impact of COVID-19 and the probable changes in the future outlook of the industry, by taking into account the technological, social, political, and economical parameters.

The ischemia reperfusion injury therapeutics market is estimated to be valued at US$ 1,582.33 million in 2020 and is expected to rise at a CAGR of 5.4% during the forecast period (2020-2027).

Figure 1: Global Ischemia Reperfusion Injury Therapeutics Market Share (%) Analysis, By Distribution Channel, 2020

An increase in the number of mergers & acquisitions, product launches, and approvals from drug regulatory authorities are expected to propel the growth of the global ischemia reperfusion injury therapeutics market.

Key players in the market are involved in mergers & acquisitions to develop and launch advanced drugs and treatment in the market. The drug launches and approvals from drug regulatory authorities are expected to facilitate the market growth and create lucrative growth opportunities for players operating in the market during the forecast period.

For instance, in November 2019, Faraday Pharmaceuticals announced positive results from phase II clinical trials of FDY-5301 for ischemia reperfusion injury treatment following a STEMI heart attack. FDY-5301 is a formulated, patented, elemental reducing agent that contains sodium iodide. It destroys the hydrogen peroxide that is naturally generated as a response to acute ischemia reperfusion injury and also contributes to loss of muscle function and mass.

In January 2020, Revive Therapeutics Ltd., a cannabis life sciences company, provided an update regarding its clinical development plan for treatment of liver disorders. The aim of the company is to expand its product pipeline by leveraging its FDA orphan drug designation for Cannabidiol in the prevention of ischemia reperfusion injury from organ transplantation.

Global Ischemia Reperfusion Injury Therapeutics Market – Regional Analysis

The market in North America accounted for majority of the share in the global ischemia reperfusion therapeutics market in 2019 owing to the increasing focus of key players on research & development and obtaining FDA approvals. For instance, in May 2019, Abiomed received the U.S. FDA approval for its STEM DTU trial of delayed ischemic reperfusion injury with impella CP. The trial will test the hypothesis that unloading the left ventricle for 30 minutes before ischemia reperfusion injury will reduce myocardial damage from a heart attack and lead to a reduction in future heart failure-related events.

Furthermore, Asia Pacific is expected to witness significant CAGR during the forecast period owing to research and development and collaborative agreements among key industry players. For instance, in May 2016, NeuroVive Asia and Sanofi entered a collaboration agreement to develop and commercialize CicloMulsion in South Korea for treatment of ischemia reperfusion injury in cardiovascular disease (CVDs). Under this agreement, NeuroVive Asia received upfront payment and royalty on future sales in the country.

Figure 2: Global Ischemia Reperfusion Injury Therapeutics Market Value (US$ Mn) & Y-o-Y Growth (%), 2017-2027

Global Ischemia Reperfusion Injury Therapeutics Market - Competitive Landscape

Key players operating in the global ischemia reperfusion injury therapeutics market are Omeros Corporation, Nyken B.V., Opsona Therapeutics Limited, Pharming Group N.V., Orexo AB, PledPharma AB, Proteo, Inc., Prolong Pharmaceuticals, Prothix BV, Zealand Pharma A/S, Stealth BioTherapeutics Inc., Amyndas Pharmaceuticals LLC, Antipodean Pharmaceuticals, Inc., Angion Biomedica Corp., Bayer AG, Bolder Biotechnology, Inc., Biomedica Management Corporation, Curatis Pharma GmbH, Erimos Pharmaceuticals, LLC, Ensemble Therapeutics Corporation, and Gilead Sciences, Inc.

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Reperfusion Treatment Market Size, Trends, Shares, Insights, and Forecast 

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Neurovascular Devices Market to Develop Rapidly by 2026

Global Neurovascular Devices Market: Overview

The global population is aging rapidly. According to WHO, the chances of health risks are greater in geriatric people than the young generation. Old age is considered to be one of the biggest risk factors that are responsible for developing various diseases such as cardiovascular and neurological conditions. It is because of these factors, the global neurovascular devices market is experiencing robust growth in the forecast period of 2018 to 2026. Moreover, various favorable government regulations such as Family Smoking Prevention and Tobacco Control Act, that allows FDA with the power to control production, marketing and use of tobacco products, are another factors that are promoting the growth of global neurovascular devices market over the period of time.

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Transparency Market Research provides a consolidated report on global neurovascular devices market. It encapsulates the various facets that can be insightful for the players who are willing to step in and grow in the market. The report enlightens developments, opportunities, challenges and key drivers that are responsible for the growth of the global neurovascular devices market during the forecast period.

Global Neurovascular Devices Market: Notable Development

The consolidated global neurovascular devices market is influenced by the activities of players such as Stryker Corporation, Johnson & Johnson, Penumbra, Inc. Abbott Laboratories, and Merit Medical Systems, Inc. These players are adopting strategies such as mergers, partnerships, and collaborations in order to acquire a competitive edge over their rivals in the global neurovascular devices market.

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Some of the notable development of the market are as follows;

In December 2016, Codman Neuro, Johnson & Johnson subsidiary took over Pulsar Vascular Inc. The acquisition was aimed at enhancing the product portfolio of the company for hemorrhagic and ischemic stroke.

Terumo Corporation, Abbott Laboratories and St. Jude Medical Inc. signed an agreement in December 2016. According to the agreement, Terumo Corporation acquired St. Jude Medical’s Angio-Seal and FermoSeal Vascular closure product line along with Abbott’s Vado Steerable Sheath. With this agreement, the acquirer enhanced its portfolio in minimal invasive site management. It also strengthened the company’s visibility in U.S. neurovascular devices market.

July 2016, marked the launch of ACE 68 Reperfusion Catheter by Penumbra, Inc. The product was launched for acute ischemic stroke treatment. The device includes the latest technologies that are designed to deliver aspiration power to its full strength so as to extract thrombus in acute ischemic stroke.

These are the development that is influencing other players of global neurovascular devices market to invest heavily in research and development in order to compete with their rivals.

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Global Neurovascular Devices Market: Key Drivers

With the launch of new and technologically advanced miniaturized neurovascular devices, the global neurovascular devices market is witnessing robust growth in the forecast period. Also, the commercialization of effective, easy-to-use, and technologically advanced neurovascular devices are influencing the growth of global neurovascular devices market in recent duration. Various developments in terms of technology, effectiveness, accuracy, and reduction in risk of traumas are one of the key factors that are promoting the growth of global neurovascular devices market.

Moreover, various government bodies across multiple countries are proactively recognizing the benefits of neurosurgical and interventional neurology products. They are heavily accepting and acknowledging devices such as stents, coils, and flow diverters to offer better neurosurgical solutions to the people of their respective countries. Owing to these reasons, the global neurovascular devices market is expected to witness robust growth in the forecast period of 2018 to 2026.

Global Neurovascular Devices Market: Regional Analysis

North America is accounted for the highest growth in the global neurovascular devices market during the forecast period. The growth of the region is attributed to the favorable reimbursement structure, especially in U.S. and extensive research and development investments along with a variety of product launches by neurosurgeons. Finally, the availability of various advanced technology to improve the efficiency and reliability of neurovascular devices is also a major factor for North America to lead other regions of global neurovascular devices market in the forecast period.

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[sapanas]

Catheter Stabilization Device Market Review, Future Growth, Share, Development Strategy, Emerging Technologies, Trends And Forecast By 2023

Global Catheter Stabilization Device Market research report, by Product type (arterial securement devices, chest drainage tube securement devices), Applications (cardiovascular procedures, radiology, respiratory procedures) – Forecast till 2023

Market Research Future (MRFR) latest study finds that the global catheter stabilization device market size is set to surge at 7.1% CAGR from 2018 to 2023. Catheter stabilization devices are standard class for suture-free stabilization of peritoneal lavage and nephrostomy and biliary percutaneous drainage catheters.

These devices play an important during procedures that involve the use of catheters.  Cardiac, neurology, urological are among the major areas where catheter stabilization finds application. The rising incidence of cardiac incidence is one of the major factors driving the market growth. In 2015, cardiovascular diseases accounted for more than 17 Mn deaths. Of these, over 6 Mn deaths were due to stroke and more than 7 Mn were due to coronary heart diseases. The data released by the American Heart Association cardiovascular diseases accounted for nearly 801,000 deaths in 2017. The healthcare cost of cardiovascular treatment is anticipated to reach USD 1044 Bn by the year 2020.

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Segmental Overview

MRFR’s study includes a detailed segmental analysis of the global catheter stabilization device market based on application, product type, end user and region.

By application, the market has been segmented into respiratory procedures, general surgery, radiology, cardiovascular procedures, urological procedures, gastric and oropharyngeal procedures and others. By product type, the market has been segmented into arterial securement devices, central venous catheter securement devices, peripheral securement devices, chest drainage tube securement devices, abdominal drainage tubes securement devices, epidural securement devices. The central venous catheter securement devices segment covers jugular securement devices, PICC securement devices, midlines securement devices, portal securement devices, subclavian securement devices and femoral securement devices. The peripheral securement devices segment covers nasogastric tubes securement devices, continuous nerve block catheter securement devices, chest drainage tube securement devices, foley catheter securement devices, endotracheal tube securement devices, ventriculoperitoneal securement devices. Abdominal drainage tube securement devices segment covers umbilical catheter securement devices, jejunal catheter securement devices and percutaneous endoscopic gastrostomy securement devices. By end users, the market has been segmented into diagnostic centers, home healthcare providers and hospitals & clinics.  

Global Catheter stabilization device market: Regional Segmentation

On the basis of region, the market has been segmented into Asia Pacific, Europe, Americas and the Middles East & Africa (MEA). The market catheter stabilization device market in Americas is expected to remain highly attractive during the forecast period. Presence of advanced healthcare infrastructure and faster adoption of innovative healthcare technologies are some of factors supporting the market growth in Americas, especially North America.

In terms of revenue, Europe holds the second spot. Increased prevalence of chronic diseases and cardiovascular disorders in the region is driving the demand for catheter-based procedures. Moreover, high healthcare expenditure and presence of public healthcare policies continues to favour the market in Europe.

Asia Pacific is also viewed as a crucial market for catheter stabilization. In fact, the APAC catheter stabilization device market is projected to witness a relatively faster growth during the forecast period. Growing need for effective diagnostic services and increased focus of improving healthcare infrastructure and an ever-growing patient pools are factors that make APAC a market with significant potentials.

Competitive Analysis

Some of top-notch companies operating in the global catheter stabilization device market include B. Braun Melsungen Ag, C. R. Bard, Inc. Convatec, Inc., Medtronic PLC, M.C. Johnson Company, Inc., 3M Company, TIDI Products, LLC., Baxter International, Inc., Merit Medical Systems, Inc., Centurion Medical Products, and Smiths Group PLC.

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Industry News

American healthcare technology company Abbott Laboratories has reportedly received the green signal from FDA for its novel sensor enabled TactiCath Contract Force Ablation Catheter. The catheter has been there in the Europe market for couple of years now.

Penumbra, a healthcare company that develops suction-based stroke clot removal devices has recently introduce two new devices; Penumbra JET 7 and Penumbra JET D Reperfusion Catheters.

[wonderlandshreyash77-blog]

Palmatine Market : Opportunity Analysis and Industry Forecast upto 2027

Palmatine is a protoberberine alkaloid extracted from the bark of medicinal plants and trees such as phellodendron amurense, coptis chinensis, enantia chlorantha, corydalis yanhusuo, radix tinosporae, and rhizoma coptidis. Palmatine is known for its anti-inflammatory, anti-tumor, anti-parasitic, anti-malarial, anti-pyretic, and anti-depressive properties. Palmatine is a major component of herbal preparations used in traditional medicines in China, South Korea, and India. It has been studied for its potential uses in the treatment of jaundice, dysentery, hypertension, inflammation, and liver-related diseases.

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Global Palmatine Market: Trends & Developments

Increase consumption of palmatine extracted from medicinal plant sources by the pharmaceutical industry has resulted in an acute shortage of palmatine. Researchers and scientists have started exploring new methods for chemically synthesizing palmatine and its active derivatives to cater to the growing demand for palmatine. Isoquinoline alkaloids such as palmatine and berberine are currently being studied for their uses in medical for the treatment of benign prostatic hyperplasia. The study is aimed to investigate the effects of berberine and palmatine on the contractility of the prostate, urethral, and vascular smooth muscle tissues in rabbits. In the last few years, palmatine has been considered as a promising DNA phototherapy drug after receiving safety clearance.

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Global Palmatine Market: Segmentation

Based on end-use industry, the global palmatine market can be segmented into pharmaceutical, food, and others. Palmatine is one of the four main protoberberine alkaloids and is largely employed in pharmaceuticals and medicines. It is used in the treatment of upper respiratory tract infections, tonsillitis, conjunctivitis, enteritis, diarrhea, urinary tract infections, surgical, and gynecological infections. Palmatine is used by the pharmaceutical industry to manufacture drugs owing to its anti-microbial and anti-viral properties. It possess the potential to inhibit activity of West Nile virus, dengue virus, yellow fever virus, and influenza virus. Palmatine can also inhibit the proliferation of a broad spectrum of gram positive and gram negative bacteria and various fungi. Palmate provides protection against myocardial ischemia-reperfusion (I/R) injury due to its antioxidant and anti-inflammatory properties.

Global Palmatine Market: Regional Outlook

In terms of region, the global palmatine market can be divided into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. Asia Pacific is expected to dominate the global market during the forecast period owing to the growing number of pharmaceutical companies, especially in countries such as India. China is projected to be a major importer of palmatine owing to presence of a significant number of chemical and pharmaceutical companies in the region that depend on raw materials such as palmatine and other alkaloids. Rising popularity of homeopathic medicines derived from palmatine and other agro-chemicals in India is expected to drive the palmatine market in the country.

[marketreasearch]

Global Ischemic Cerebral Stroke market report provides an in-depth overview of Product Specification, technology, product type and production analysis considering major factors such as Revenue, Cost, Gross and Gross Margin

Global Ischemic Cerebral Stroke market report provides an in-depth overview of Product Specification, technology, product type and production analysis considering major factors such as Revenue, Cost, Gross and Gross Margin.

The global Ischemic Cerebral Stroke market report also contains the drivers and restrains for the market that are derived from SOWT analysis, and also shows what all the recent developments, product launches, joint ventures, merges and accusations by the several key players and brands that are driving the market are by systemic company profiles.

The Global Ischemic Cerebral Stroke Market is expected to reach USD 42.17 billion by 2025, from USD 22.78 billion in 2017 growing at a CAGR of 8.0% during the forecast period of 2018 to 2025. The upcoming market report contains data for historic years 2016, the base year of calculation is 2017 and the forecast period is 2018 to 2025.

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Competitive Analysis: 

The global ischemic cerebral stroke market is highly fragmented and the major players have used various strategies such as new product launches, expansions, agreements, joint ventures, partnerships, acquisitions, and others to increase their footprints in this market. The report includes market shares of global continuous glucose monitoring market for global, Europe, North America, Asia Pacific and South America.

For instance, Stempeutics Research Pvt.,Ltd.(Bangalore) developed a drug Stempeucel which is expected to show efficient results in the forecast period leading to the growth of ischemic cerebral stroke market. Currently, Stempeucel is under phase II clinical trials for treatment of ischemic cerebral stroke.

Global Ischemic Cerebral Stroke Market By Drug Type ( Anticoagulation Therapy, Revascularization, Reperfusion, Antiplatelet, Neuroprotective), End User (Hospitals, Clinics, Palliative Care, Ambulatory Surgery Centers),Geography (North America, South America, Europe, Asia-Pacific, Middle East and Africa) – Industry Trends and Forecast to 2025

Reasons to Purchase this Report · Current and future of Global Ischemic Cerebral Stroke Market outlook in the developed and emerging markets · The segment that is expected to dominate the market as well as the segment which holds highest CAGR in the forecast period. · Regions/countries that are expected to witness the fastest growth rates during the forecast period · The latest developments, market shares, and strategies that are employed by the major market players Customization of the Report · The report includes the complete segmentation displayed above across all above mentioned countries

Major Market Competitors/Players: 

Some of the major players operating in the global ischemic cerebral stroke market are:-

Abbott Laboratories,

Medtronic plc,

Boston Scientific Corporation,

Cordis Corporation, 

Koninklijke Philips N.V. ,

GE Healthcare,

Stryker Corporation,

Genentech, Inc.,

Merck & Co., Inc., 

Bayer AG ,

Boehringer Ingelheim ,

Sanofi,

Covidien plc ,

Philips Healthcare,

Johnson & Johnson,

Penumbra, Inc., 

GE Healthcare, 

Siemens Healthcare,

Hitachi, Ltd ,

Biogen,

Daiichi Sankyo ,

Pfizer Inc.,

ThromboGenics NV,

Vernalis plc,

Neurotec Pharma SL.

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Market Definition: 

Ischemic cerebral stroke is the disease in which  blood vessels supplies to brain are blocked due to the formation of blood clots which is a cause loss of neurologic function. The symptoms of ischemic cerebral stroke are abrupt onset of hemiparesis, quadriparesis and monoparesis, monocular visual loss, diplopia, visual field deficits, hemisensory deficits, dysarthria, facial droop, vertigo, ataxia, nystagmus, aphasia and decrease in the level of consciousness. According to the American Heart Association, in 2016, approximately 795,000 people suffered from stroke in U.S. Stroke is the major cause  of approximately 130,000 people death  in a year. According to the World Health Organization, 15 million people suffers stroke worldwide each year. Of these, 5 million die and another 5 million are permanently disabled. High blood pressure contributes to more than 12.7 million strokes worldwide wherein Europe averages approximately 650,000 stroke deaths occurred annually. In the ischemic stroke treatment drug type segment, warfarin is the highest revenue generating class of drug. Due to the increasing incidence of ischemic cerebral stoke disease worldwide drives the ischemic cerebral stroke market.

Major Market Drivers and Restraints:

Increase in the number of cerebral     stroke cases.

High prices for AIS therapy.

Increase prevalence of acute ischemic     strokes.

Limited availability of efficient drugs     is restricting the market growth.

Market Segmentation: 

The global ischemic stroke market is     segmented based on drug type, testing, end user, geography.

Based on drug type the market is     segmented into anticoagulation therapy, revascularization, reperfusion,     antiplatelet, neuroprotective. On the basis of anticoagulation therapy,     the market is classified into

Based on geography, the market report     covers data points for 28 countries across multiple geographies namely     North America & South America, Europe, Asia-Pacific and, Middle East     & Africa. Some of the major countries covered in this report are U.S.,     Canada, Germany, France, U.K., Netherlands, Switzerland, Turkey, Russia,     China, India, South Korea, Japan, Australia, Singapore, Saudi Arabia,     South Africa and, Brazil among others

Key Developments in the Market:

In 2015, Silk Road Medical, Inc.(U.S)     got the FDA 510(K) approval for Anti-Stroke Enroute Device.

In 2015, NeuroVive Pharmaceutical     AB(Sweden), entered into collaboration with BBB therapeutics, for     development of the NVP014 drug candidate used in the treatment of ischemic     strokes.

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[erectiledysfunc]

erectile dysfunction 28 year old male

Contents

Previous year.. virag

Massachusetts male aging study (mmas

Erectile dysfunction (ed)

Hypertensive men 41-58 years

can constipation affect erectile dysfunction  · I onced told my urologist that my anal area was always painful and itchy. I asked him if it had anything to do with my erectile dysfunction. He said that they shared the same nerve system, but he doubts if they are related. I read somewhere that erectile dysfunction can.mayo clinic erectile dysfunction treatment erectile dysfunction review article treatment erectile dysfunction The global erectile dysfunction Treatment Market, by Product (Viagra (Sildenafil citrate), Cialis (Tadalafil), Stendra/Sperda, Levitra/Staxyn, Zydena (Udenafil), and Vitaros (Alprostadil Cream.The Raiders are in better shape in their business and football operations in Las Vegas than at any time during the 25-year.Mothers-to-be should “bump” their tobacco habit. Before pregnancy is best, but the sooner they can, the better. Tobacco smoke contains a deadly mix of more than 7,000 chemicals, which contribute to.

Keywords: erectile dysfunction; prevalence; distress; risk factors. Introduction. group of 51-y-old Danish men.18 In the question- naire, 5%. to-face and questionnaire study,21 996 male respon-. any degree during the previous year.. virag and Becky-Ardilly28. 1037. 18-70. 28. 11. Bjin17. 20055. 18-69. 28. 19 .

The most common sexual problem in men as they age is erectile dysfunction (ED ). In general, the younger a man is, the better his sexual.

Ischemia reperfusion (IR) injury may be attenuated through succinate dehydrogenase (SDH) inhibition by dimethyl malonate.

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Objectives To develop, calibrate, test and validate a logistic regression model for accurate risk prediction of sudden.

However, with the exception of one 15-year-old anatomical observation [11], any functional connectivity. freely explore.

Rethink the news: Reducing news to hard lines and side-taking leaves a lot of the story untold. Progress comes from.

The massachusetts male aging study (mmas) found that 52% of men between 40 and 70 years old reported having some form of erectile dysfunction (ed).1.

Tested samples of the tablet marketed as ‘V8’ contained 90-100 mg of glyburide, a dose 5 to 10 times higher than that used in.

America is speaking," said 18-year-old Derrick Grant, looking out at a crowd that came together in North Plainfield.

treatments used in the management of male erectile dysfunction (ED); to. Figure 28. Dyspepsia (Treatment-related): Patients With Hypertension on Antihypertensive. Drugs. The prevalence of hypogonadism was higher in men 50 years versus. 11 hypertensive men 41-58 years old. . Oral moxonidine, 0 . 4-0.6 mg/d;.

In 2015 while in high school, Christian Abayisenga started hanging out with friends whom he later found out were smokers -.

natural remedies to help erectile dysfunction The global adult diapers market is set to gain momentum from the increasing prevalence of incontinence worldwide. The Global Forum on Incontinence states that in 2018, more than 424 million people all.

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Residency · Summer Fellowships · Old Urology Video Series Page. The Male Sexual Dysfunction Panel was created in 2013 by the American. risk factors is paralleled by the worldwide increase in the prevalence of ED.15, 28-30. risk).19 Prevalence of ED is higher in men with diabetes who are older than 50 years,

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[healthy-insights]

Thrombectomy Devices Market Research Report: Forecast up to 2022

As per the findings of a fresh intelligence study by Transparency Market Research (TMR), The Global Thrombectomy Market is largely fragmented, which is a reflection of the presence of a vast number of International and domestic companies. That being said, a few players are ahead of the curve too, such as Stryker Corporation, whose strategy of maintaining a strong product portfolio and acquisition is bearing fruits. The TMR report identifies Argon Medical Devices Inc., Boston Scientific Corporation, BTG International Ltd., Edwards Lifesciences Corporation, Johnson & Johnson, Medtronic PLC, Penumbra, Inc., Phenox GmbH, Spectranetics Corporation, Terumo Corporation, and Teleflex Incorporated as some of the other companies holding a prominent position in the global thrombectomy devices market.

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 Demand for Thrombectomy Devices Estimated to Increment at CAGR 6.1% until 2022

As per the projections of the TMR report, the demand in the global thrombectomy devices market will increment at a healthy CAGR of 6.1% during the forecast period of 2017 to 2022. The overall revenue in the market is estimated to reach a valuation of US$1,974.5 mn by 2022, substantially up from the evaluated worth of the global thrombectomy devices market at US$1,470.6 mn in 2017. In the near future, the key companies are expected to invest on the research and development of advanced products, acquire strategically, price their products aggressively, and put emphasis on strengthening their sales force across various geographies to gain shares. For instance, Penumbra launched thrombectomy device ACE 68 Reperfusion Catheter in July 2016, opening it for commercial usage in and across the U.S. These catheters makes use of the latest tracking technology and can deliver maximum aspiration power for the exaction of thrombus in stroke intervention. Boston Scientific is another highly respectable name in the global thrombectomy devices market, leading the innovation for peripheral vascular disease in the industry and consistently expands its product portfolio.

Product-wise, the global thrombectomy devices market currently gains maximum demand for aspiration thrombectomy devices, which was valued at US$420.6 mn in 2017, representing 28.6% of the total demand that year. The absolute growth of this segment is expected to remain larger than any other segment. Geographically, the developed country of the U.S. makes North America the most lucrative region, which is poised to generate a demand for thrombectomy devices worth of US$776.3 mn by 2022. The demand in the North America thrombectomy market is anticipated to increment at a CAGR of 6.4% during the forecast period of 2017 to 2022.

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 Growing Population of Potential Patients Augmenting Demand

The demand in the global thrombectomy devices market is driven by a number of factors, such as growing population of targeted patients, consistent improvements made in the technology, favorable medical reimbursement scenario in a number of developed, increasing expenditure on healthcare in several emerging markets, and growing demand for minimally invasive thrombectomy procedures. The TMR report detects a growing trend of acquisition of small specialized clinics by tier-1 hospitals, which is influencing an increase in the patient care management, as it helps in the training of healthcare staff, nurses, and physicians. Rise in the prevalence of cardiovascular and cerebrovascular diseases and technological advancements with the advent of laser and UV radiation are some of the other factors augmenting the demand in the global thrombectomy devices market.

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 Limited Number of Skilled Surgeons Obstructing Market’s Prosperity

The global thrombectomy devices market has a fruitful future, but the prosperity of the market is challenged quite a factors too, such as stringent regulatory scenario, dearth of skilled and experience surgeons, limited awareness among the patients regarding the latest treatment procedures for peripheral vascular diseases, increase in product recalls, and adverse effects of thrombectomy devices.

 Thrombectomy Devices Market Report is available @ US$ 5795

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