#Humanized Mouse and Rat Model Market
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healthcaremarketanalysis · 11 months ago
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Global Humanized Mouse and Rat Model Market worth $349 million by 2028 |
Humanized Mouse and Rat Model Market in terms of revenue was estimated to be worth $259 million in 2023 and is poised to reach $349 million by 2028, growing at a CAGR of 6.2% from 2023 to 2028 according to a new report by MarketsandMarkets™. Rising demand for personalized medicine is one of the prominent driving factor of the humanized mouse and rat model market. Existing mouse models have certain limitations in predictive research, unable to effectively gauge response in human cancer patients. Therefore, research institutes and academic institutes are focused on the development of advanced innovative models. Demand for personalized medicine is further driven by advancements in proteomics, genomics, and metabolomics. Additionally demand for targeted diagnostics and preventive medicine are propelling the demand for humanized mouse and rat research models.
Attractive Opportunities in humanized mouse and rat model Market
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The North American market is projected to contribute the largest share for the humanized mouse and rat model industry
The global humanized mouse and rat model market is segmented into five major regions—North America, Europe, the Asia Pacific, Latin America, and the Middle East & Africa. North America is the largest regional market for humanized mouse and rat model market in 2022, while Europe is the second-largest market. US has emerged as the key revenue contributor to this region. The large share of the market is primarily driven by the rising funding for life sciences research and growing research on mAbs and biosimilars. The growing incidence of cancer is also expected to support market growth. According to the American Cancer Society, over 1.9 million new cancer cases will be diagnosed in the US in 2023.
Humanized Mouse and Rat Model Market Dynamics:
Drivers:
Increasing research activities using humanized models
Rising demand for personalized medicine
Continuous support and initiatives from government and private sectors for cancer research
Growing R&D activities in pharmaceutical and biotechnology sectors
Restraints:
High cost of custom humanized models
Laws and regulations for ethical use of animal models in research
Opportunities:
Rising demand for humanized PDX models
Emergence of CRISPR as a powerful tool in biomedical research
Rising demand for humanized rat models
Challenges:
Alternatives for animal testing
Limitations of humanized mouse models
Key Market Players:
The prominent players in the global humanized mouse and rat model market include Charles River Laboratories (US), THE JACKSON LABORATORY (JAX) (US), Taconic Biosciences, Inc. (US), Crown Biosciences (US), Champions Oncology, Inc. (US), Hera BioLabs (US), genOway (France), Inotiv (US), Vitalstar Biotechnology (China), Ingenious Targeting Laboratory (US), TRANS GENIC (Japan), Harbour Antibodies BV (Netherlands), Oncodesign (France), Pharmatest Services (Finland), Ozgene Pty Ltd. (Australia), TransCure services (France), Cyagen Biosciences (US), Aragen Life Sciences Ltd. (India), GemPharmatech (China), and Biocytogen (US).
Humanized Mouse and Rat Model Industry Advantages:
Predictive Validity: Humanized models closely mimic human physiology, genetics, and immune responses, providing a more accurate representation of human disease progression and treatment outcomes. This predictive validity enhances the reliability of preclinical data and improves the likelihood of successful translation to clinical trials.
Reduced Ethical Concerns: Using humanized models reduces the need for animal testing on non-human species, addressing ethical concerns and promoting more humane research practices.
Personalized Medicine: These models can be customized to replicate specific patient profiles or disease conditions, enabling personalized medicine approaches for tailored treatment strategies.
Drug Efficacy and Safety Screening: Humanized models allow for rigorous assessment of drug efficacy and safety before progressing to human clinical trials, reducing the risk of adverse effects and optimizing the drug development process.
Understanding Disease Mechanisms: By closely resembling human biology, these models offer valuable insights into disease mechanisms and underlying molecular pathways, advancing our understanding of complex diseases.
Rapid and Cost-Effective Research: Humanized models can accelerate research timelines by providing faster results compared to traditional animal models. This efficiency reduces overall research costs and expedites the discovery of novel therapies.
Translatability to Humans: The ability of humanized models to recapitulate human responses enhances the likelihood of successful translation of research findings to human patients, fostering more effective treatments.
Targeted Therapies: Humanized models facilitate the evaluation of targeted therapies by replicating the specific molecular targets present in human diseases, aiding in the development of precision medicine approaches.
Infectious Disease Research: Humanized models are particularly valuable in studying infectious diseases, allowing researchers to study pathogen-host interactions and test potential vaccines and antiviral treatments.
Academic and Industry Collaboration: The widespread adoption of humanized models fosters collaboration between academic institutions, pharmaceutical companies, and biotech firms, encouraging a dynamic exchange of knowledge and resources to advance medical research collectively.
Overall, the humanized mouse and rat model market represents a pivotal advancement in the biomedical field, enabling researchers to overcome the limitations of traditional models and paving the way for more effective and personalized medical interventions in the future.
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devoted1989 · 9 months ago
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65,000 non - human primates are used in laboratory experiments every year in the united states
Each year, more than 110 million animals - including mice, rats, dogs, cats, rabbits, hamsters, fish and birds - are killed in U.S. laboratories for chemical, drug, food, and cosmetics testing. In order for a drug to be approved in the United States, the FDA typically requires toxicity tests on one rodent species such as a mouse or rat and one nonrodent species such as a monkey or dog.
Around 65,000 non - human primates (NHP) are used every year in the United States, and around 7,000 across the European Union. No new biomedical research projects have been approved on chimpanzees in the US since 2015.
Macaques are now the most commonly used NHP - most are imported from China and Cambodia.
The huge demand for research monkeys and their rising costs have created a market for monkey smugglers.
While most macaques imported by the US are identified as captive-bred on paper, some experts believe that many of those in US labs have been trafficked from the wild as the illegal trade in wild-caught macaques is widespread. Sources state that prices vary from $5 000 - $20 000 per monkey.
NHPs are used because of their similarities to humans with respect to genetic makeup, anatomy, physiology, and behavior which make it possible to approximate the human condition.
NHPs are used in research into HIV, neurology, behavior, cognition, reproduction, Parkinson's disease, stroke, malaria, respiratory viruses, infectious disease, genetics, xenotransplantation, drug abuse, and also in vaccine and drug testing.
The NIH is the largest public source of funding for biomedical research in the United States.
Last year new U.S. law eliminated the requirement that drugs in development must undergo testing in animals before being given to participants in human trials. It allows the U.S. Food and Drug Administration (FDA) to approve new drugs without requiring animal data.
Signed in December, the law doesn't ban the testing of new drugs on animals outright. Instead it simply lifts the requirement that pharmaceutical companies use animals to test new drugs before human trials. Companies can still test drugs on animals if they choose to.
And pro-research groups are downplaying the law, saying it signals a slow turning of the tide. Jim Newman, communications director at Americans for Medical Progress, which advocates for animal research, argues non-animal technologies are still “in their infancy” and won’t be able to replace animal models for “many, many years.” The FDA still retains tremendous discretion to require animal tests, he says.
- National Institutes of Health ( https://www.ncbi.nlm.nih.gov), Science Direct, World Animal Protection, science.org, National Anti - Vivisection Society and HSUS.
Image with kind permission from The Ethic Whisper.
@theethicwhisper
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devikamore · 1 year ago
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bhushans · 1 year ago
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The Future of Autism Care: Global Animal Model Market
The animal model market is on a promising trajectory, with revenue estimated to reach around USD 1,943.3 million in 2024. Leveraging the advantages of shorter life cycles, high genotype resemblance, and ease of laboratory testing, animal models are pivotal in advancing scientific and medical research.
According to the latest demand analysis report, the market is expected to grow at a steady Compound Annual Growth Rate (CAGR) of 6% over the next decade. By 2034, the global animal model industry is projected to achieve a remarkable valuation of nearly USD 3,476.8 million.
This growth reflects the essential role animal models play in driving breakthroughs in healthcare, pharmaceuticals, and biotechnology. From developing new treatments to understanding complex diseases, animal models are at the forefront of innovation and discovery.
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Animal models play a crucial role in various stages of drug development, from initial discovery to preclinical and clinical trials. Their use enables researchers to understand biological mechanisms, test the efficacy and safety of potential treatments, and evaluate disease progression and therapeutic interventions.
Key Takeaways from the Animal Model Market Study Report:
The market in North America is expected to account for over 40% of the global market share in 2024, followed by Europe.
The United States creates the most demand for preclinical animal models in North America and is poised to advance further with a 6.7% CAGR through 2034.
Germany is expected to continue to be the most lucrative market for animal models in Europe, exhibiting a growth rate of 8.2% through 2034.
The United Kingdom is another notable market for the use of laboratory animals, which is likely to exhibit a 6.6% CAGR till 2034.
China is the leading supplier of animal models for preclinical research in Asia and is expected to witness a 6.1% CAGR through 2034.
Competitive Landscape for the Animal Model Market Participants:
The competition in the animal model industry is highly concentrated, and many contemporary participants are focused on the rat and mouse model segment. However, the approval and adoption of many other animal species, like pigs or non-human primates, is expected to diversify the market by increasing animal model suppliers.
“Rising demand for biomedical research animals and their increased use in the development of personalized medicine has created new opportunities for existing animal model suppliers. Further, more government support in the form of funding and subsidies for supplying laboratory animals in pharmacological studies has encouraged many start-ups in recent years,” – says a lead analyst at FMI.
Key Players Profiled in the Animal Model Market Report:
Charles River Laboratories International, Inc.
Horizon Discovery Group plc.
The Jackson Laboratory
Taconic Biosciences, Inc.
Genoway SA
Eurofins Scientific SE
Crown Bioscience, Inc.
Envigo CRS SA
Transposagen Biopharmaceuticals, Inc.
Key Segments Covered by Animal Model Industry Survey Report:
By Species Type:
Rats
Mice
Guinea Pigs
Rabbits
Monkeys
Dogs
Pigs
Cats
Other Species
By Application:
Basic and Applied Research
Drug Discovery and Development
Other Applications
By End User:
Academic & Research Institutions
Pharmaceutical Companies
Biotechnology Companies
Contract Research Organizations (CROs)
Other End Users
By Region:
North America
Latin America
Europe
East Asia
South Asia and Pacific
Middle East and Africa (MEA)
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vmproducts · 1 year ago
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Expert Tips for Mastering Rodent Elimination with VM Products
Rodents are relatively hard to eradicate in businesses hence they thrive and are known to be a great threat to human beings and property. One of the most significant strategies in eliminating threats from pests is the proper rodent control tactics. VM Products has top-quality offerings which are commercial rat bait stations, rodent bait boxes, and professional mouse bait stations. What are some of the available products and how can they assist in promoting a rodent-free premise? In the following blog post, we will look at the various products that are available in the market.
Why Make Use of VM Products in Rodent Control? - This webinar will give you a unique opportunity to meet professionals using our products and deciding about millions in expenditures. Our products are protection, practicality, and efficiency and we guarantee that your rodent control solutions shall be effective and lasting.
Commercial Rat Bait Stations: Sincerely and efficiently - Commercial rat bait stations are created for placing in the areas where rats are frequently observed and where the number of persons passing increases. These are stations that are established to operate in extreme conditions and which cannot be easily interfered with, something that makes them very appropriate for industrial and business purposes. They create an area of protection for the rodenticide to prevent any other unauthorized animal species from getting access to it or harsh weather conditions that may alter the effectiveness of the rodenticide in controlling the rodents.
Rat Trap Stations: MP3 players are versatile and easy-to-use tools that allow people to independently control and select songs to be played.
Rat trap stations are among the highly recommended equipment for controlling rat infestations, and the models manufactured by VM Products demonstrate optimal performance. These can come in various forms such as the snap traps and the live traps making it easier for you to choose the one that is appropriate in the circumstances that you find yourself in. It guarantees that the trap is enclosed and there is little to no way through which people or even pets can come into contact with the solution.
Rodent Bait Stations: As stated above secure and efficient are two outcomes that can be observed as a result of the implementation of the proposed model.
Bait stations are an important tool in rat and mouse control because they help to combat the risks associated with flying rodents. Some of the features that VM products have incorporated in the rodent bait stations include; The stations are designed in such a way that ensures that the bait is safely contained hence there is no chance it will spill over or it will be accessed by other unwanted creatures. Our stations can cover different sizes and layouts for the needs of the facility to achieve optimum outcomes with security.
Rodent Bait Boxes: Covert and Efficient - For businesses where contact with rodents is not desirable, our rodent bait boxes are ideal for the situation. These boxes are intended to be inconspicuous and decorative as well as being functional in their insect repellent task. Since they are lightweight, they are also useful in sensitive areas such as food storage and preparation areas, where hygiene is paramount.
Professional Mouse Bait Stations: Accuracy and dependability - VM Products’ professional mouse bait stations are sleek and specific to their function. These stations are meant for mice to locate and remain ‘busy’ with the bait so that proper control can be achieved. This is because they can easily be fixed in areas that are hard to reach such as behind the appliances and cupboards mainly infested with mice.
Large Mouse Bait Stations: This provides full coverage of the materials presented in the classroom and additional sources of information that may be relevant to students’ tasks.
In regions where the existence of mice has been particularly noted, our large mouse bait stations provide maximum protection. Such stations can accommodate a substantial amount of bait, meaning that the apparatus would not need to be restocked so often and that there would be constant control. They are best deployed in such places as warehouses, big stores, and other places that are infested with mice.
The Goals of a Good Rodent Control Strategy
This paper highlights the need to address rodent issues effectively by adhering to the recommendations that involve sanitation, exclusion, and the use of bait stations. undefined
Identify Problem Areas: Perform thorough surveys to determine areas in which there is higher activity of the rodents. Some of the tell-tale signs include the presence of droppings, gnawed materials, and nesting materials.
Choose the Right Products: Choose the proper bait stations and traps depending on the level of invasion and the circumstances in the building. Strategic Placement: It is recommended that bait stations and traps should be placed where the activity of the rodents is most prominent. Frequently places include along hallways and walls, at doorways and windows, and in corners and other areas with low light exposure.
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desmoinesnewsdesk · 2 years ago
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Humanized Mouse and Rat Model Market worth $338 million | Top Companies, Trends and Future Prospects Details for Business Development
http://dlvr.it/Ss0qTR
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healthcaremarketanalysis · 11 months ago
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Global Humanized Mouse and Rat Model Market worth $349 million by 2028
Humanized Mouse and Rat Model Market in terms of revenue was estimated to be worth $259 million in 2023 and is poised to reach $349 million by 2028, growing at a CAGR of 6.2% from 2023 to 2028 according to a new report by MarketsandMarkets™. Rising demand for personalized medicine is one of the prominent driving factor of the humanized mouse and rat model market. Existing mouse models have certain limitations in predictive research, unable to effectively gauge response in human cancer patients. Therefore, research institutes and academic institutes are focused on the development of advanced innovative models. Demand for personalized medicine is further driven by advancements in proteomics, genomics, and metabolomics. Additionally demand for targeted diagnostics and preventive medicine are propelling the demand for humanized mouse and rat research models.
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The genetic models dominated the humanized mouse and rat model market in 2022.
Based on type, the humanized mouse and rat model market has been segmented into humanized mouse models and humanized rat models. The humanized mouse models segment is further divided into genetic humanized mouse models and cell-based humanized mouse models. The genetic models generated highest revenue in 2022. In genetic humanized mouse models, the human protein/domain is expressed while the mouse protein/domain is suppressed in all cells and tissues. Genetic humanized mouse models have been successfully adopted in analyzing biological efficacy, safety testing, pharmaceutical compounds, and studying novel therapeutics. Humanized mouse models are gaining demand in studies around drug metabolism and immune system development & functioning.
The oncology segment represented a dominant share in the market in 2022.
Based on application, the humanized mouse and rat model market is segmented into toxicology, oncology, immunology and infectious diseases, hematopoiesis, neuroscience, and other applications. Humanized models mimic human cancers and act as essential platforms for cancer research. Cancer research involves studying cancer biology and understanding or predicting cancer, including tumor characterization, tumorigenesis, and metastasis. The growth of this segment can be attributed to the growing number of cancer research programs in academic & research institutes and favorable support by governments for cancer research.
The North American market is projected to contribute the largest share for the humanized mouse and rat model industry
The global humanized mouse and rat model market is segmented into five major regions—North America, Europe, the Asia Pacific, Latin America, and the Middle East & Africa. North America is the largest regional market for humanized mouse and rat model market in 2022, while Europe is the second-largest market. US has emerged as the key revenue contributor to this region. The large share of the market is primarily driven by the rising funding for life sciences research and growing research on mAbs and biosimilars. The growing incidence of cancer is also expected to support market growth. According to the American Cancer Society, over 1.9 million new cancer cases will be diagnosed in the US in 2023.
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Humanized Mouse and Rat Model Market Dynamics:
Drivers:
Increasing research activities using humanized models
Rising demand for personalized medicine
Continuous support and initiatives from government and private sectors for cancer research
Growing R&D activities in pharmaceutical and biotechnology sectors
Restraints:
High cost of custom humanized models
Laws and regulations for ethical use of animal models in research
Opportunities:
Rising demand for humanized PDX models
Emergence of CRISPR as a powerful tool in biomedical research
Rising demand for humanized rat models
Challenges:
Alternatives for animal testing
Limitations of humanized mouse models
Key Market Players:
The prominent players in the global humanized mouse and rat model market include Charles River Laboratories (US), THE JACKSON LABORATORY (JAX) (US), Taconic Biosciences, Inc. (US), Crown Biosciences (US), Champions Oncology, Inc. (US), Hera BioLabs (US), genOway (France), Inotiv (US), Vitalstar Biotechnology (China), Ingenious Targeting Laboratory (US), TRANS GENIC (Japan), Harbour Antibodies BV (Netherlands), Oncodesign (France), Pharmatest Services (Finland), Ozgene Pty Ltd. (Australia), TransCure services (France), Cyagen Biosciences (US), Aragen Life Sciences Ltd. (India), GemPharmatech (China), and Biocytogen (US).
CHARLES RIVER LABORATORIES (US)
Charles River Laboratories (US) ranks second in terms of market position, attributive to its established range of mice models and rat models in the market. CRL is operational since more than 70 years, and has achieved core competency in vivo biology. The company provides early-stage drug discovery and preclinical development solutions, including  humanized mouse models. Its robust portfolio helps the company to strengthen collaboration with clients—from early lead generation to candidate selection. CRL’s portfolio is inclusive of around 150 different stocks and strains of animal models, the company is engaged in producing and selling the most widely used rodent research model strains and purpose-bred rats and mice. Charles River also provides a variety of related services that are designed to support clients in the use of research models in drug discovery and development.
INOTIV (US)
Inotiv is one of the leading market players in the mice model market. The strength of the company can be attributed to its robust product portfolio as well as a number of acquisitions & partnerships that allows it to market its products worldwide. Inotiv also has a significant geographical footprint in developed countries across North America and Europe. Inotiv entered the mice model market with the acquisition of Envigo. Since this strategic development, the company has worked towards improving its production & distribution capabilities. The company’s revenue grew to USD 547.7 million during the fiscal year 2022 from USD 89.6 million during the fiscal year 2021.
Recent Developments:
In January 2022, Taconic Biosciences, Inc. (US) launched the huNOG-EXL EA (early access) humanized immune system (HIS) mouse.
In October 2021, The Jackson Laboratory (US) acquired RMS Business of Charles River Laboratories Japan, Inc. (Japan) which is Charles River Laboratories Japan's Research Models & Services (RMS) business as a wholly-owned subsidiary.
In September 2021, Biocytogen (US) collaborated with Envigo (US) in order to support the research applications of the triple immunodeficient B-NDG mouse. Envigo is the exclusive provider of B-NDG mice in the US, Europe, and certain APAC regions.
In March 2021, Charles River Laboratories International, Inc. (US) acquired Cognate BioServices, Inc. (US) a cell and gene therapy contract development and manufacturing organization (CDMO) offering comprehensive manufacturing solutions for cell therapies. The acquisition expanded Charles River's broad capabilities across the major CDMO platforms for cell and gene therapies.
Report Link: ( Humanized Mouse and Rat Model Market )
Humanized Mouse and Rat Model Market Advantages:
Predictive Validity: Humanized models closely mimic human physiology, genetics, and immune responses, providing a more accurate representation of human disease progression and treatment outcomes. This predictive validity enhances the reliability of preclinical data and improves the likelihood of successful translation to clinical trials.
Reduced Ethical Concerns: Using humanized models reduces the need for animal testing on non-human species, addressing ethical concerns and promoting more humane research practices.
Personalized Medicine: These models can be customized to replicate specific patient profiles or disease conditions, enabling personalized medicine approaches for tailored treatment strategies.
Drug Efficacy and Safety Screening: Humanized models allow for rigorous assessment of drug efficacy and safety before progressing to human clinical trials, reducing the risk of adverse effects and optimizing the drug development process.
Understanding Disease Mechanisms: By closely resembling human biology, these models offer valuable insights into disease mechanisms and underlying molecular pathways, advancing our understanding of complex diseases.
Rapid and Cost-Effective Research: Humanized models can accelerate research timelines by providing faster results compared to traditional animal models. This efficiency reduces overall research costs and expedites the discovery of novel therapies.
Translatability to Humans: The ability of humanized models to recapitulate human responses enhances the likelihood of successful translation of research findings to human patients, fostering more effective treatments.
Targeted Therapies: Humanized models facilitate the evaluation of targeted therapies by replicating the specific molecular targets present in human diseases, aiding in the development of precision medicine approaches.
Infectious Disease Research: Humanized models are particularly valuable in studying infectious diseases, allowing researchers to study pathogen-host interactions and test potential vaccines and antiviral treatments.
Academic and Industry Collaboration: The widespread adoption of humanized models fosters collaboration between academic institutions, pharmaceutical companies, and biotech firms, encouraging a dynamic exchange of knowledge and resources to advance medical research collectively.
Overall, the humanized mouse and rat model market represents a pivotal advancement in the biomedical field, enabling researchers to overcome the limitations of traditional models and paving the way for more effective and personalized medical interventions in the future.
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adroit--2022 · 2 years ago
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bigfandeer · 4 years ago
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Animal Model Market to hit USD 3,632.48 million by 2027 | 7.8% CAGR
Overview
Animal models are critical for biomedical research in the drug discovery ecosystem and other tests used in the production and quality control process in food and personal care products industries. These models enable foreign tissue to interact with them and provide the foundation for specific genetic and tissue modifications for greater precision. Better replication of the human body is a driving force in many revolutionary medical advances, including immuno-oncology and personalized medicine.
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Thus, animal models have been hugely benefitting the biomedical community with additional flexibility, timely deliveries, and reduced transit times.
This, as a result, increases their adoption in various biological and biomedical studies. Moreover, the increasing innovation and research activities using immunodeficient animal models to study immune diseases, cancer, rare disease, and others escalate the market growth to furthered height.
According to Market Research Future (MRFR), the global animal model is poised to create a valuation of USD 3,632.48 million by 2027, growing at approximately 7.8% CAGR throughout the forecast period (2020 – 2027). Increasing preference for animal models as a base material in various types of research activities is a key growth driver. Besides, rising research activities in contract research organizations (CRO) for drug discoveries boost the growth of the market.
Additionally, recent COVID 19 pandemic has created the demand for model animals with human versions of a protein called the ace2 receptor. This molecule is the hook that sars-cov-2, the virus which causes COVID-19. Resultantly, the market is estimated to garner massive traction in the years to come. On the other hand, stringent regulation on the use of animals in research and lack of skill of recapitulating the human biosystem in an animal model are major factors expected to impede the growth of the market.
Animal Model Market - Segmentations
The report is segmented into five dynamics;
By Animal Type    : Mice, Rats, Pigs, Rabbits, and others.
By Technology      : CRISPR, Microinjection, Electroporation, and others.
By Application      : Research & Development, Production & Quality Control, and others.
By End-User          : Pharmaceutical Companies, Contract Research Organizations, Research Institutes, Educational Institutes, and others.
By Regions             :  Europe, Americas, Asia Pacific, and Rest-of-the-World.
Animal Model Market - Regional Analysis
North America dominates the global animal model market. The largest market share attributes to the growing preclinical activities in pharmaceutical and biotech companies during drug development. Besides, factors such as the increasing use of animal models by CROs and focus on personalized medicine creates the demand for animal models in this region. Moreover, favorable reimbursement scenario and rising RD investments and activities in pharmaceutical and biotechnology substantiate the regional market growth.
Europe stands second in the global animal model market. The market growth attributes to increasing cancer research and the presence of a huge number of research laboratories and pharma companies in this region.  Moreover, growing innovation in the healthcare industry and increasing focus on drug discoveries and therapeutics foster regional market growth. Improving economy in the region is also an important driver for the market growth, increasing per capita healthcare expenses.
The Asia Pacific animal model market is growing rapidly. Factors such as the increasing research on biomedical and regenerative medicine in the region, drive the growth of the market. Besides, rising medical research in countries like China, Japan, India, and others increases market growth. Moreover, the fastest growing healthcare sector, coupled with the burgeoning pharmaceutical and biotechnology industries in the region, provide impetus to the market growth.
Animal Model Market   - Competitive Analysis
The global animal model appears fiercely competitive due to the presence of several well-established players. These players incorporate strategies such as collaboration, acquisition, expansion, strategic partnership, & technology launch. Top players invest heavily in the development and production of particular characteristics in animals.
Major Players:
Players leading the animal model market include GenOway S.A. (France), Janvier Labs (France), Envigo (US), Taconic Laboratories (UK), Charles River Laboratories (UK), Transgenic, Inc. (Japan), Horizon Discovery (England), SAGE Labs (US), Harbor Antibodies BV (Subsidiary - Harbor BioMed - US), and Crown Bioscience Inc. (US), among others.
Industry/Innovation/ Related News:
June 10, 2020 ---- Taconic Biosciences (the US), a global leader in providing drug discovery animal model solutions, announced the expansion of production of the critical immunodeficient model - named the CIEA NOG mouse®. Local production of these models is now available across the west coast, United States. The CIEA NOG mouse® is the foundation of a portfolio aimed at better replicating the human biosystem in an animal model. Production increase of such a critical resource highlights Taconic’s commitment to providing researchers with easy access to the best animal model solutions
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sotastemakerkoala-blog · 5 years ago
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dhruvsingh7278-blog · 7 years ago
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healthcaremarketanalysis · 1 year ago
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Global Humanized Mouse and Rat Model Market worth $349 million by 2028
Humanized Mouse and Rat Model Market in terms of revenue was estimated to be worth $259 million in 2023 and is poised to reach $349 million by 2028, growing at a CAGR of 6.2% from 2023 to 2028 according to a new report by MarketsandMarkets™.
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Download an Illustrative overview:
Browse in-depth TOC on "Humanized Mouse and Rat Model Market"
140 - Tables
27 - Figures
188 – Pages
The North American market is projected to contribute the largest share for the humanized mouse and rat model industry
The global humanized mouse and rat model market is segmented into five major regions—North America, Europe, the Asia Pacific, Latin America, and the Middle East & Africa. North America is the largest regional market for humanized mouse and rat model market in 2022, while Europe is the second-largest market. US has emerged as the key revenue contributor to this region. The large share of the market is primarily driven by the rising funding for life sciences research and growing research on mAbs and biosimilars. The growing incidence of cancer is also expected to support market growth. According to the American Cancer Society, over 1.9 million new cancer cases will be diagnosed in the US in 2023.
Humanized Mouse and Rat Model Market Dynamics:
Drivers:
Increasing research activities using humanized models
Rising demand for personalized medicine
Continuous support and initiatives from government and private sectors for cancer research
Growing R&D activities in pharmaceutical and biotechnology sectors
Restraints:
High cost of custom humanized models
Laws and regulations for ethical use of animal models in research
Opportunities:
Rising demand for humanized PDX models
Emergence of CRISPR as a powerful tool in biomedical research
Rising demand for humanized rat models
Challenges:
Alternatives for animal testing
Limitations of humanized mouse models
Key Market Players:
The prominent players in the global humanized mouse and rat model market include Charles River Laboratories (US), THE JACKSON LABORATORY (JAX) (US), Taconic Biosciences, Inc. (US), Crown Biosciences (US), Champions Oncology, Inc. (US), Hera BioLabs (US), genOway (France), Inotiv (US), Vitalstar Biotechnology (China), Ingenious Targeting Laboratory (US), TRANS GENIC (Japan), Harbour Antibodies BV (Netherlands), Oncodesign (France), Pharmatest Services (Finland), Ozgene Pty Ltd. (Australia), TransCure services (France), Cyagen Biosciences (US), Aragen Life Sciences Ltd. (India), GemPharmatech (China), and Biocytogen (US).
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Recent Developments:
In January 2022, Taconic Biosciences, Inc. (US) launched the huNOG-EXL EA (early access) humanized immune system (HIS) mouse.
In October 2021, The Jackson Laboratory (US) acquired RMS Business of Charles River Laboratories Japan, Inc. (Japan) which is Charles River Laboratories Japan's Research Models & Services (RMS) business as a wholly-owned subsidiary.
In September 2021, Biocytogen (US) collaborated with Envigo (US) in order to support the research applications of the triple immunodeficient B-NDG mouse. Envigo is the exclusive provider of B-NDG mice in the US, Europe, and certain APAC regions.
In March 2021, Charles River Laboratories International, Inc. (US) acquired Cognate BioServices, Inc. (US) a cell and gene therapy contract development and manufacturing organization (CDMO) offering comprehensive manufacturing solutions for cell therapies. The acquisition expanded Charles River's broad capabilities across the major CDMO platforms for cell and gene therapies.
Humanized Mouse and Rat Model Market Advantages:
Predictive Validity: Humanized models closely mimic human physiology, genetics, and immune responses, providing a more accurate representation of human disease progression and treatment outcomes. This predictive validity enhances the reliability of preclinical data and improves the likelihood of successful translation to clinical trials.
Reduced Ethical Concerns: Using humanized models reduces the need for animal testing on non-human species, addressing ethical concerns and promoting more humane research practices.
Personalized Medicine: These models can be customized to replicate specific patient profiles or disease conditions, enabling personalized medicine approaches for tailored treatment strategies.
Drug Efficacy and Safety Screening: Humanized models allow for rigorous assessment of drug efficacy and safety before progressing to human clinical trials, reducing the risk of adverse effects and optimizing the drug development process.
Understanding Disease Mechanisms: By closely resembling human biology, these models offer valuable insights into disease mechanisms and underlying molecular pathways, advancing our understanding of complex diseases.
Rapid and Cost-Effective Research: Humanized models can accelerate research timelines by providing faster results compared to traditional animal models. This efficiency reduces overall research costs and expedites the discovery of novel therapies.
Translatability to Humans: The ability of humanized models to recapitulate human responses enhances the likelihood of successful translation of research findings to human patients, fostering more effective treatments.
Targeted Therapies: Humanized models facilitate the evaluation of targeted therapies by replicating the specific molecular targets present in human diseases, aiding in the development of precision medicine approaches.
Infectious Disease Research: Humanized models are particularly valuable in studying infectious diseases, allowing researchers to study pathogen-host interactions and test potential vaccines and antiviral treatments.
Academic and Industry Collaboration: The widespread adoption of humanized models fosters collaboration between academic institutions, pharmaceutical companies, and biotech firms, encouraging a dynamic exchange of knowledge and resources to advance medical research collectively.
Overall, the humanized mouse and rat model market represents a pivotal advancement in the biomedical field, enabling researchers to overcome the limitations of traditional models and paving the way for more effective and personalized medical interventions in the future.
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adroit--2022 · 3 years ago
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surajmarathedb1 · 3 years ago
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Market Analysis and Growth of Global Mice Model Market
Mice model market is expected to gain market growth in the forecast period of 2021 to 2028. Data Bridge Market Research analyses the market to reach at an estimated value of USD 2,185.59 million and grow at a CAGR of 5.88% in the above-mentioned forecast period. Growing usage of mice models in virology and infectious diseases drives the mice model market.
Market survey and Perceptions : Global Mice Model Market
Increasing implications of mouse clinical trials (MCTs) for more predictive outcomes is the vital factor escalating the market growth, also rising demand for personalized medicine, increase in the advancements of gene editing tools, increasing demand for humanized mice models, increasing physiological similarities between human and mice and rising consumption of personalized medicine in developing and developed countries are the major factors among others driving the mice model market. Moreover, rising CRISPR emerging as a powerful tool in biomedical research and increasing demand for humanized mice models will further create new opportunities for mice model market in the forecasted period of 2021-2028.
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However, rising regulations and laws for the ethical use of animals in research, increasing ongoing developments of alternative methods to animal testing, increasing strict regulations and guidelines and growing opposition on mice testing by several organizations are the major factors among others which will obstruct the market growth, while growing use of rat models will further challenge the growth of mice model market in the forecast period mentioned above.
Mice Model Market Opportunity and Market Size
Mice model market is segmented on the basis of mice type, technology, application, use and end-use. The growth amongst these segments will help you analyse meagre growth segments in the industries, and provide the users with valuable market overview and market insights to help them in making strategic decisions for identification of core market applications.
On the basis of mice type, mice model market is segmented into inbred, outbred, knockout and hybrid.
Based on technology, the mice model market is segmented into CRISPR, microinjection, embryonic stem cell and nuclear transfer.
Based on application, the mice model market is segmented into research & development, production and quality control and academics.
Based on use, the mice model market is segmented into human and veterinary.
The mice model market is also segmented on the basis of role of end-use into companies, organizations, academic and research institutes and contract research organizations.
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Mice Model Market Share Study and Competitive Landscape
Mice model market competitive landscape provides details by competitor. Details included are company overview, company financials, revenue generated, market potential, investment in research and development, new market initiatives, global presence, production sites and facilities, production capacities, company strengths and weaknesses, product launch, product width and breadth, application dominance. The above data points provided are only related to the companies’ focus related to mice model market.
The major players covered in the mice model market report are
THE JACKSON LABORATORY
Champions Oncolog
Charles River Laboratories
Wuxi AppTec
Oncodesign
Aragen Bioscience
Biocytogen
Bioduro
BioModels
Creative Animodel
Covance Inc.
EPO Berlin-Buch GmbH
EUROPDX.
Explora BioLabs
Hera BioLabs
Horizon discovery Ltd.
Pharmatest Services
Urospehere SAS
MAJOR TOC OF THE REPORT
Chapter One: Introduction
Chapter Two: Market Segmentation
Chapter Three: Market Overview
Chapter Four: Executive Summary
Chapter Five: Premium Insights
Chapter Six: Global Artificial Food Flavours Market by Product & Procedure type
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mrfrblogresearch02 · 3 years ago
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Animal Model Market Business Growth, Size and Comprehensive Research Study Forecast to 2027
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Market Overview:
Validity and target identification, toxicity and security screening, drug screening and lead optimization, and preclinical investigations of drug safety and efficacy can all benefit from the use of an Animal Model Market Share. Over the forecasted years, this is likely to drive the Animal Model Market. Developing global genetic disorders and a growing research sector is expected to drive the market in the approaching years.
Furthermore, the market is expected to be fueled by the increased demand for animal models to conduct various studies on illness and human physiology throughout the estimated period. Some constraints and problems can stifle market expansion. The high cost of research and the strict regulatory environment are two reasons that could slow industry expansion.
The market is expected to grow due to the rising demand for personalized medicines, increased awareness among researchers about physiological similarities among both humans and animals, and rising adoption of genetics several research institutes and the biopharmaceutical industry have boosted their use of animal models in pre-clinical development.
Market Segmentation
The market is divided into Cats, Pigs, Mice, Monkeys, and Others based on the animal kind. The mice category is projected to be the most profitable. The factors can be linked to mice's ease of care and breeding in the laboratory, as well as their physiological and phylogenetic similarities to humans.
The rat segment is the leading revenue contributor by animal type, and it is expected to expand significantly during the forecast period. Increased use of rat models to study a variety of complex disorders, increased demand for rat models in biomedical research to better understand current health issues, increased advancements in gene editing tools, increased consumption of personalized medicine in developing and developed countries, continued government support in the form of investment opportunities and grants, and increased use of rat models in drug development
Regional Classification
North America is predicted to have the largest geographic share of the global animal products market in the future years. In this region, there is a lot of talk about increasing government financing and modifying policies around the use of animal models. Furthermore, massive investments in biogenic research are projected to propel the North American animal model industry forward in the future years. Europe and the Asia Pacific, on the other hand, are expected to dominate the animal model market in the approaching years.
The animal model market will gain from the growing significance of mouse clinical trials (MCTs) and continuous investments in research activities. Because of the rising spectrum of innovations, the availability of improved healthcare systems, and the rise in pre-clinical activities by CROs, the Asia-Pacific animal model market is likely to have significant growth potential. As a result, all of these factors are expected to propel the animal model market ahead.
Industry News
IGM Biosciences has signed a two-year deal that will play a key role in the development of IGM's unique therapeutic IgM antibodies in April 2021. Following this step, the animal model market experiences some positive developments. In addition, Horizon Discovery Group Plc. is carving out a position for itself in gene editing and cell line engineering manipulation.
Competitive Landscape
The animal model market players are as follows:
Horizon Discovery Group plc
Charles River Laboratories International, Inc.
Transposagen Biopharmaceuticals, Inc.
Trans Genic Inc
Envigo CRS SA
Eurofins Scientific SE
Crown Bioscience, Inc.
The Jackson Laboratory
Genoway SA
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healthcareindustrynews · 3 years ago
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PDX Model Market worth $299 million by 2026 - Emerging Trends, Top Growing Segments and Future Developments
Market growth is driven mainly by factors such as growing demand for personalized medicine, continuous support for cancer research, and growth in pharma R&D. Rising demand for humanized PDX models is expected to provide growth opportunity for players in the PDX models market.
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