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What is Wellbutrin?

Wellbutrin (bupropion) is an antidepressant medication used to treat seasonal affective disorder.

Wellbutrin may also be used for purposes not listed in this medication guide.

Important information

You should not take Wellbutrin if you have seizures, an eating disorder, or if you have suddenly stopped using alcohol, seizure medication, or sedatives. If you take Wellbutrin for depression, do not also take Zyban to quit smoking.

Do not use bupropion if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

Wellbutrin may cause seizures, especially in people with certain medical conditions or when using certain drugs. Tell your doctor about all of your medical conditions and the drugs you use.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using this medicine. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

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Do not use Wellbutrin if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

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an eating disorder such as anorexia or bulimia; or

if you have suddenly stopped using alcohol, seizure medication, or a sedative (Valium, Nembutal, Seconal, Solfoton, and others).

Wellbutrin may cause seizures, especially in people with certain medical conditions. Tell your doctor about all of your medical conditions.

Do not take Wellbutrin to treat more than one condition at a time. If you take this medicine for depression, do not also take Zyban to quit smoking.

To make sure this medicine is safe for you, tell your doctor if you have:

a history of head injury, seizures, or brain or spinal cord tumor;

narrow-angle glaucoma;

heart disease, high blood pressure, history of heart attack;

diabetes;

kidney or liver disease (especially cirrhosis); or

bipolar disorder (manic depression).

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using Wellbutrin. Your family or other caregivers should also be alert to changes in your mood or symptoms.

FDA pregnancy category C. It is not known whether Wellbutrin will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.

See also: Pregnancy and breastfeeding warnings (in more detail)

Bupropion can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.

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Take Wellbutrin exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Too much of this medicine can increase your risk of a seizure.

Do not crush, chew, or break an extended-release tablet. Swallow it whole.

You should not change your dose or stop using Wellbutrin suddenly, unless you have a seizure while taking this medicine. Stopping suddenly can cause unpleasant withdrawal symptoms.

Do not stop using Wellbutrin suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.

This medicine can cause you to have a false positive drug screening test. If you provide a urine sample for drug screening, tell the laboratory staff that you are taking buproban.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of bupropion can be fatal. Overdose symptoms may include muscle stiffness, hallucinations, fast or uneven heartbeat, shallow breathing, or fainting.

What should I avoid while taking Wellbutrin?

Drinking alcohol with bupropion may increase your risk of seizures. If you drink alcohol regularly, talk with your doctor before changing the amount you drink. Bupropion can also cause seizures in people who drink a lot of alcohol and then suddenly quit drinking when they start using the medication.

Bupropion may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

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Get emergency medical help if you have any of these signs of an allergic reaction to Wellbutrin: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

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Report any new or worsening symptoms to your doctor.

Call your doctor at once if you have:

a seizure (convulsions);

a manic episode - racing thoughts, increased energy, reckless behavior, feeling extremely happy or irritable, talking more than usual, severe problems with sleep;

blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;

fast heartbeats;

severe skin reactionfever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common Wellbutrin side effects may include:

dry mouth, nausea, stomach pain;

headache, dizziness, ringing in your ears;

vision changes;

loss of interest in sex;

sore throat, muscle pain;

mild itching or skin rash, increased sweating, increased urination; or

changes in appetite, weight loss or gain.

Where can I get more information?

Your pharmacist can provide more information about Wellbutrin.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Wellbutrin only for the indication prescribed.

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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