#Nanobodies Market Size

[poonamcmi]

Nanobodies Market Poised to Grow at a Robust Pace Owing to Wide Range of Medical Applications

The nanobodies market has been gaining significant traction over the past few years owing to the wide ranging medical applications of these antibodies. Nanobodies, also known as single domain antibody fragments or VHHs, are gaining popularity as an alternative to conventional monoclonal antibodies. As compared to conventional antibodies, nanobodies exhibit better stability, solubility and affinity for targets. They are able to bind to sites that are difficult for conventional antibodies to access. Nanobodies also have a smaller size which enables them to penetrate deeper into tissues.

The growing research and development activities focused on utilizing Nanobodies Market Size for various therapeutic applications such as oncology, inflammatory diseases and infectious diseases are expected to boost market revenue significantly over the forecast period. Nanobodies can be developed for treating conditions such as cancer, cardiovascular diseases, ophthalmic diseases and others. They help in inhibiting the activity of target proteins more effectively. Some key advantages of nanobodies over conventional antibodies are high tissue penetration capabilities, robust manufacturing processes and lowered production costs.

The Global Nanobodies Market is estimated to be valued at US$ 567.68 Mn in 2024 and is expected to exhibit a CAGR of 24% over the forecast period from 2024 to 2031.

Key Takeaways - Key players operating in the nanobodies market are 3M, Auto Custom Carpet Inc., Autotech Nonwovens Pvt Ltd., Conform Automotive, Feltex, GAHH LLC, RACEMARK International, LLC, Lloyd Mats Inc., German Auto Tops Inc., Lear Corporation (Masland Corporation), Low & Bonar PLC, Suminoe Textile Co., Ltd., Toyota Boshoku Corporation, Walser GmbH, MacNeil Automotive Products Limited (WeatherTech), Husky Liners, Inc. (Truck Hero, Inc.), and Lund International, Inc.

- Growing R&D investments by biopharmaceutical companies to leverage nanobody-based drugs for various therapeutic applications present lucrative growth opportunities over the forecast period.

- Increasing collaborations between Nanobodies Size And Trends  and drug makers aimed at facilitating the development and commercialization of nanobody-based drugs globally.

- Growing adoption of nanobodies across developed markets of North America and Europe. However, the Asia Pacific region is expected to witness the highest growth over the forecast period owing to initiatives to promote nanotechnology research.

Market Drivers: - Wide ranging medical applications of nanobodies in conditions such as oncology, Cardiovascular diseases and infectious diseases. Nanobodies help in developing more targeted therapies.

- Robust manufacturing processes and lower production costs of nanobodies make them an attractive alternative to conventional antibodies.

PEST Analysis Political: The nanobodies market growth is influenced by government investments and funding for development of innovative nanotechnology solutions. Regulations also impact development and commercialization of nanobodies.

Economic: Factors such as growth in healthcare spending, increasing disposable incomes, and demand for affordable treatment options impact the nanobodies market growth positively. The rising need for cost-effective diagnostic and treatment drives opportunities.

Social: Increasing awareness and acceptance of nanotechnology drives the adoption of nanobodies, especially in advanced applications such as molecular imaging and targeted drug delivery. The growing population and demand for personalized healthcare boost market growth.

Technological: Advancements in nanotechnology and development of innovative nanobody therapeutics and diagnostics expand applications in areas such as cancer treatment, infectious diseases, and imaging. Continued R&D for safer and affordable solutions presents new opportunities.

Geographical Regions with Highest Market Concentration North America and Europe currently hold the major market share owing to presence of major players, advanced healthcare infrastructure, and growing R&D investments. Within North America, the U.S. accounts for the largest share due to high healthcare spending and availability of latest technologies. Rapidly developing Asian markets like China and India also offer lucrative prospects with increasing investments in healthcare sector and demand for cost-effective therapies.

Fastest Growing Region The Asia Pacific region is poised to grow at the fastest pace over the forecast period. Factors such as rising healthcare expenditures, growing geriatric population, increasing investments by market players, and progress in nanotechnologies are expected to boost the market. Growing cases of chronic diseases and demand for affordable diagnosis and treatment makes this region highly lucrative. Developing nations also aim to strengthen their healthcare infrastructure further creating opportunities. Get More Insights On, Nanobodies Market About Author: Money Singh is a seasoned content writer with over four years of experience in the market research sector. Her expertise spans various industries, including food and beverages, biotechnology, chemical and materials, defense and aerospace, consumer goods, etc. (https://www.linkedin.com/in/money-singh-590844163)

[capralogics01]

The Differences Between Llama and Rabbit Antibodies

Which Is Right for You?, Introduction: When it comes to cutting-edge research and advancements in biotechnology, antibodies have emerged as a pivotal tool. Scientists and researchers are increasingly exploring alternative sources for these vital biomolecules, with llama and rabbit antibodies gaining significant attention. Both offer unique advantages that cater to diverse research needs. In this blog, we will delve into the differences between llama and rabbit antibodies to help you make an informed choice for your specific research requirements.

Llama Antibodies: Llama antibodies, also known as "nanobodies," are a relatively novel class of antibodies that have gained popularity in recent years. Their compact size allows them to access hidden epitopes, enabling researchers to target specific antigens with higher precision. Due to their simplicity and stability,llama antibodies can withstand extreme conditions, making them suitable for challenging experiments.

Rabbit Antibodies: Rabbit antibodies, on the other hand, have been extensively used in research for several decades. Their diverse immune responses generate a wide range of high-affinity antibodies, making them ideal for various applications, including immunohistochemistry and western blotting. Additionally, the abundance of rabbit antibodies in the market ensures a broad selection for researchers.

Choosing the Right Antibodies: Selecting the appropriate antibodies depends on the experimental requirements, target specificity, and intended applications. Llama antibodies excel in situations demanding high stability and access to unique epitopes. In contrast, rabbit antibodies offer versatility and a wide array of target options.

Conclusion: In summary, boththese antibodies have distinct features that suit different research contexts. For personalized guidance on selecting the right antibodies for your research needs, consult the experts at Capralogics (www.capralogics.com), a leading provider of high-quality antibodies and custom antibody services. Remember to assess your experimental goals carefully before making an informed decision for successful research outcomes.

[sabalevaishali]

Nanobodies Market is estimated to value over USD xx billion by 2027 end and register a CAGR of xx% from the forecast period 2020-2027.

The report initiates from the outline of business surroundings and explains the commercial summary of chain structure. Moreover, it analyses forecast By Product Type, By Indication, By Distribution Channel, By Region and Nanobodies Market.

Additionally, this report illustrates the corporate profiles and situation of competitive landscape amongst numerous associated corporations including the analysis of market evaluation and options associated with the worth chain. This report provides valuable insights on the general market profit through a profit graph, an in depth SWOT analysis of the market trends alongside the regional proliferation of this business vertical.

[myabhijitr]

Nanobodies Market - Global Industry Insights, Trends, Outlook, and Analysis, 2018-2026

Nanobodies are considered to be one of the best technology in the fields of research, diagnostics and therapy especially in cancer research. These technology was developed from antigen binding fragments, originating from Camelid heavy-chain antibodies. These molecules do not have light chains, which is an essential part of antibody found in humans. Based on the above finding, nanobodies molecule containing single-domain only were developed, and these molecules contain functional and structural properties similar to heavy chain antibodies. These molecules have several advantages as compared to the conventional antibodies such as small-size, nano to picomolar affinities, and multiple route of administration. Ablynx, which is acquired by Sanofi S.A., is one of the leading company in this market.

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Nanobodies Market Drivers

Currently, no products are available in the market, but there are multiple products in the pipeline including few in very late stage of clinical trials. For instance, marketing authorization application for Caplacizumab for the treatment of acquired thrombotic thrombocytopenic purpura (aTTP) has been submitted to European Medicine Agency (EMA) in February 2017. The product, Caplacizumab, is expected to be launched in Europe in 2018. Moreover, the company, Ablynx, is expected to file for biologic license agreement to the U.S. Food and Drug Administration (FDA) in 2018, and is expected to launch this product in U.S. in 2019. Both, Europe and U.S. are the key markets for any biologics including monoclonal antibodies and are expected to be the high revenue generating market for nanobodies.

Nanobodies Market Regional Analysis

Europe is expected to hold dominant position in global nanobodies market, owing to the first mover advantage. Marketing authorization application (MMA) to EMA for Caplacizumab was filed by Ablynx in February 2017, and the company expects to get approval in 2018. If approved, Europe will be the only market to have nanobodies commercially available. However, North America is expected to show rapid growth in this market, as the company is planning to file for biologic license agreement for the same product to U.S. FDA in 2018, and expects to get approval from FDA by 2019. Once approved in U.S., the company may plan to reap the maximum benefit out of it.

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Nanobodies Market Restraint

Presently, there are no products in market, and more than two-third products in very early phase of development, and these products have to go through various phases of clinical development. Failure in clinical trials for these products or slow approval by the regulatory bodies in the market may prove to be vital restraint in this market.

Nanobodies Market Key Players

Ablynx (now part of Sanofi S. A.) is the key player in the global nanobodies market. Moreover, the company is developing various products with leading biology companies such as Novo Nordisk A/S, Merck & Co., Inc., Merck KGaA, AbbVie, Inc., and C.H. Boehringer Sohn AG & Ko. KG.

Nanobodies Market Taxonomy:

The global nanobodies market is segmented on the basis of product type, indication, distribution channel, and region: By Product Type- Mono-specific, Monovalent, Multivalent, Bi-paratopic, Multi-specific,. By Indication Acquired Thrombotic Thrombocytopenic Purpura (aTTP), Respiratory Syncytial Virus (RSV) Infection, Rheumatoid Arthritis, Systemic Lupus Erythematosus, Oncology, Immune?mediated Inflammatory Diseases (IMID), Psoriasis, Chronic Kidney Diseases, Bone Disorders, Others,. By Distribution Channel - Hospital Pharmacies, Retail Pharmacies, Online Pharmacies,. By Geography- North America, Latin America, Europe, Asia Pacific, Middle East, Africa,.

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[industry365]

Biosensors Market Is Expected To Reach New Growth Revenues During 2021-2028

The global biosensors market size is expected to reach USD 40.53 billion by 2028 according to a new study by Polaris Market Research. The report “Biosensors Market Share, Size, Trends, Industry Analysis Report, By Technology (Thermal, Electrochemical, Piezoelectric, Optical); By Application; By End-Use; By Region; Segment Forecast, 2021 – 2028” gives a detailed insight into the current market dynamics and provides analysis on future market growth.

The introduction of nanotechnology-based biosensors, usage of instruments in blood sugar level monitoring in diabetes patients, increasing demand for home-based point-of-care devices due to the COVID-19 pandemic, increasing advancement in technology, and mounting government policies toward diagnostics are some of the significant factors that may complement the global industry development.

Several new technologies have been developed in recent years which will revolutionize biosensor technology. Nano-biosensors have emerged in recent years, and they are increasingly used in various genomics and proteomic techniques.

Have Questions? Request a sample or make an Inquiry before buying this report by clicking the link below:  https://www.polarismarketresearch.com/industry-analysis/biosensors-market/request-for-sample

The wide application of the product in the medical field will drive the growth of the industry. It is used in various medical section, including drug discovery, blood gas analyzer, cholesterol checking, infectious diseases, and blood glucose monitoring. Such devices are an essential tool in detecting several conditions, from diabetes to cancer, and thus contribute to industry growth.

There are several developments in the global industry in recent times due to its popularity and increased adoption. Fox BIOSYSTEMS launched a white Fox biosensor in March 2021. The biosensor is developed to overcome clogging in samples such as whole blood or lysates. It can detect microvesicles, nanobodies, antibodies, phage, and small molecules, and the probe in this biosensor is based on generic surface chemistry.

The COVID-19 pandemic is expected to further drive the growth of the global industry during the forecast period owing to the adaptation of the product in COVID-19 diagnosis and monitoring. Various companies are developing new COVID-19 associated products at different development levels, and these products are soon expected to be launched in the industry.

Market Participants such as Abbott Laboratories, Bayer AG, AZUR Environmental, Biosensor BV, DuPont Biosensor Materials, Cranfield Biotechnology Centre, Pinnacle Technologies Inc., Johnson & Johnson, Ercon, Inc., EG & IC Sensors, Inc., Strategic Diagnostics, Innovative Biosensors Inc., Sysmex Corporation, LifeScan, Inc., QTL Biosystems, Molecular Devices Corp., and Roche Diagnostics are some of the key players operating in the global market.

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Polaris Market Research has segmented the biosensors market report on the basis of product, application, end-use, and region:

Biosensors, Technology Outlook (Revenue – USD Million, 2016 – 2028)

Thermal

Electrochemical

Piezoelectric

Optical

Biosensors, Application Outlook (Revenue – USD Million, 2016 – 2028)

Medical

Food Toxicity

Bioreactor

Agriculture

Environment

Others

Cholesterol

Blood Glucose

Blood Gas Analyzer

Pregnancy Testing

Infectious Testing

Biosensors, End-Use Outlook (Revenue – USD Million, 2016 – 2028)

Home Healthcare Diagnostics

POC Testing

Food Industry

Research Laboratories

Security and Biodefense

Biosensors Market, Regional Outlook (Revenue – USD Million, 2016 – 2028)

North America

Europe

Asia Pacific

Latin America

Middle East & Africa

U.S.

Canada

Germany

UK

France

Italy

Spain

Austria

Netherlands

China

India

Japan

South Korea

Malaysia

Indonesia

Brazil

Mexico

Argentina

South Africa

Saudi Arabia

UAE

Israel

Buy Now: https://www.polarismarketresearch.com/checkouts/9031

[healthcare-market]

TMR Analyzes Impact of Outbreak of COVID-19 on Nano Antibodies Market

Global Nano Antibodies Market: Overview

· Nano antibodies are a novel class of proprietary therapeutic proteins based on single-domain antibody fragments that contain unique structural and functional properties of naturally-occurring heavy chain only antibodies. Nano antibodies, also known as nAb, are single-domain VHH antibodies derived from the Camelidae family of mammals such the llamas, camels, and alpacas.

· Nano antibodies are easier to produce in bulk than polyclonal antibodies. Additionally, these are stable at a range of temperatures and extreme pH levels. Moreover, relatively small size of nano antibodies allows for easy genetic engineering, thereby lowering overall production cost.

Read Report Overview: https://www.transparencymarketresearch.com/nano-antibodies-market.html

Key Drivers of Global Nano Antibodies Market

· Increase in incidence of cancer has induced practitioners and non-specialists to use nano antibodies for practice and surgery. Moreover, in the past few years, nano antibodies have been extensively used in oncology and hematology procedures for the treatment of life-threatening diseases. This is projected to be a key driver of the global nano antibodies market.

· However, nanobodies have significant limitations and disadvantages, which restrains usage. The heavy chain antibodies from which nanobodies are developed can only be obtained from camelids. Traditional monoclonal antibodies, on the other hand, are obtained from mice. Therefore, the development of nano antbodies requires larger, more complicated housing and animal husbandry for obtaining the desired antibody.

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North America to Account for Major Share of Global Nano Antibodies Market

· In terms of region, the global nano antibodies market can be segmented into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa

· North America is projected to dominate the global market during the forecast period. Rise in prevalence of chronic diseases and increase in investments by leading drug manufacturers in research & development activities that could bring new developments and inventions pertaining to nano antibodies are anticipated to drive the market in the region.

· The market in Asia Pacific is expected to grow at a rapid pace due to increase in investment by emerging markets such as China and India in R&D and surge in health care spending

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[watchtowermaya]

Integration of nanomaterials into the entire food supply. Installation of AI nanomaterials for agro-food inspection. Hybrid probes installed into foods that insert platforms into your body. Injection of nanobodies into your food. The World Economic Forum informed us that our food supply was going to be disrupted, begin

[rupalic]

Isoflavones Market: Growth Opportunities and Recent Developments

The global isoflavones market is estimated to be valued at USD 1.2 billion in 2019 and is projected to grow at a CAGR of 4.7% to reach USD 1.5 billion during the forecast period. Growth in this industry is driven by the increasing incidences of chronic diseases, rising prevalence of cancer, technological advancements in the manufacturing of isoflavones, the rapidly increasing geriatric population and so on. By Source, the soy segment is expected to lead the isoflavones market. Prominent dietary sources of isoflavones include soy milk and plant-based alternatives. Several calcium-fortified soy drinks that are rich in fiber and proteins are given preference in countries such as Germany, France, and Switzerland. The consumption of soy isoflavones as food ingredients or food supplements reduces the risk of breast cancer and growth of cancer cells by reducing the cell mitosis process, which fuels the demand for soy as a major source of isoflavones. By application, the pharmaceutical segment is projected to account for the largest share during the forecast period. Based on application, the isoflavones market is segmented into pharmaceuticals, nutraceuticals, cosmetics, and food & beverages. The pharmaceuticals segment accounted for the largest share, owing to its therapeutic and functional properties; isoflavones are used in the treatment for chronic and cardiovascular diseases. Download PDF Brochure: https://www.marketsandmarkets.com/pdfdownloadNew.asp?id=161667005 Key players in isoflavone market include Cargill (Germany), ADM (US), BASF (Germany), DSM (Netherlands), International Flavors and Fragrances (Frutarom) (US), Shanghai Freemen (US), Nexira Inc. (France), Bio-gen Extracts, Sikko Industries, SK Bioland (South Korea), BioMax (India), Avestia Pharma (India), NutraScience Labs (US), Tradichem S.L. (Spain), Nutra Green Biotechnology (China), Herbo Nutra (India), FutureCeuticals Inc. (US), Bio-gen Extracts (US), Xena Bio Herbals Pvt. Ltd. (India), Sikko Industries (India), Biomax (India), and Lactonova (India). North America to lead the market during the forecast period. The North American region accounted for the largest share of the isoflavones market. Increasing cases of obesity in North America increase the focus on weight management techniques & attracting consumers toward healthy and natural food products with natural ingredients, thereby propelling the demand for isoflavones in the region. Market Dynamics Driver: Prevalence of menopausal issues Women in their menopause stage experience various issues such as hot flashes, insomnia, and, in numerous cases, sexual dysfunction. Many women prefer supplements containing estrogen, which may significantly increase the risk of blood clots, stroke, or breast or uterine cancer. Thus, estrogen may not be an option for many women, depending on their health and family health history. Women are currently inclining toward supplements with naturally therapeutic ingredients to manage their menopause symptoms with fewer risks. In response to such changing preferences of women, supplement manufacturers have turned to natural alternatives. They have started utilizing soy isoflavones instead of estrogen, as it mimics the estrogen characteristics and provides estrogen effects that aid in reducing menopausal symptoms such as hot flashes and fatigue. Owing to the rising issues related to menopause and women’s inclination toward supplements with natural alternatives, the demand for isoflavones from the nutraceutical industry is projected to grow in the coming years Restraint: Stringent regulatory requirements Isoflavones come under the active pharmaceutical ingredient (API) category; hence, manufacturers have to follow the rules and regulations imposed for all API products. Pharmaceutical API manufacturers across the globe are witnessing a rise in the demand for APIs, which results in a positive outlook for the market. However, the increasing stringency of regulations is considered as a major restraint that may limit the growth prospects of the market. According to the report, “Fine chemicals stringent regulations prompt return of manufacturing to the west,” published by IHS Chemical Week in January 2015, the demand for APIs is expected to grow at a consistent rate, while the supply of APIs manufactured with international Good Manufacturing Practice (GMP) standards and world-class documentation is not keeping pace with this demand. Opportunity:Emerging technologies Some of the recent advancements in drug development include the use of nanotechnology for the synthesis of APIs. The emergence of nanoparticle technologies for efficient delivery of APIs shows promising potential as a novel and efficient approach. Nanobodies are similar to single-domain antibodies that can bind to specific antigens; however, they are much smaller in size than antibodies. Nanobodies are rapidly becoming an attractive technology platform for pharmaceutical development. Chitosan and Eudragit nanoparticles of Genistein, the predominant isoflavone found in soy products for cancer therapy, have been significantly evaluated for the treatment of chronic diseases in the past few years. The delivery of Genistein-loaded Chitosan and Eudragit S100 loaded polymeric nanoparticles has proven to be a feasible approach to treat cancer. Speak to Analyst: https://www.marketsandmarkets.com/speaktoanalystNew.asp?id=161667005 Similarly, bispecific antibodies, which can bind to two different epitopes either on the same or different target, are attracting the attention of market players. Such emerging technologies have the potential to create attractive opportunities for market players. Challenge: Less efficiency compared to alternatives Soy isoflavones can take several weeks or more to reach their maximal benefit. For example, as per Healthline Media (US), a 2015 review found that soy isoflavones take more than 13 weeks to reach just half of their maximum effect. Traditional hormones such as estrogen therapy, on the other hand, take about three weeks to show the same benefit. However, possible adverse effects such as heart attacks and strokes associated with conventional estrogen therapy are projected to enable pharmaceutical and nutraceutical manufacturers to opt for isoflavones derived from natural resources.

[wiseguy111]

Nanobodies are a novel class of proprietary therapeutic proteins based on single-domain antibody fragments that contain the...

[pharmaphorumuk]

Inside MoonLake’s raid on Merck KGaA’s inflammatory disease hopeful sonelokimab

Swiss biotech MoonLake Immunotherapeutics has emerged with what it hopes is one of the hottest drugs in inflammatory diseases, sonelokimab. In an interview with pharmaphorum’s news editor Richard Staines, chief operating officer Arnout Ploos van Amstel revealed how the biotech and its “mystery CEO” managed to swoop for the drug ahead of big pharma rivals.

Arnout Ploos van Amstel is no stranger to the cut-throat world of inflammatory disease drugs, a market that is worth billions and has spawned some of the biggest blockbusters ever.

His latest plan is to supplant one of the biggest drugs in that market: Novartis’ Cosentyx (secukinumab), which generated more than a billion dollars in revenues in the last quarter alone in diseases including psoriasis and ankylosing spondylitis.

It’s a drug that Ploos van Amstel helped to launch earlier in his career when he worked at Novartis – and he thinks sonelokimab could knock Cosentyx from its position as the leading drug in its class.

The mechanism of action is slightly different as sonelokimab inhibits both IL-17A and IL-17F and has an albumin binding site.

This and its smaller size – it’s a “nanobody” that is only a fraction of the size of conventional antibodies – could allow it to penetrate deeper into the skin and joints.

Shortly after the launch of MoonLake at the beginning of this month The Lancet published some tantalising phase 2b data in moderate to severe psoriasis that suggest MoonLake could be on the right course with sonelokimab.

The study is not powered to show superiority to Cosentyx but up to 57% of patients with moderate to severe psoriasis who took sonelokimab achieved clear skin (PASI 100) at week 24 and sustained responses over 52 weeks.

There was also a numerical benefit over a Cosentyx control arm and a favourable safety profile.

According to Ploos van Amstel, sonelokimab could be an “IL-17 2.0” and have a similar impact on this niche in the inflammatory diseases market that covers psoriasis and related diseases such as psoriatic arthritis (PSA), ankylosing spondylitis (AS) and hidradenitis suppurativa (HS).

He told pharmaphorum: “When we launched Cosentyx it was game changing compared with TNFs (tumour necrosis factor class drugs) and had efficacy data that was much better.

“Sonelokimab is such a big step forward again; you have something that is vastly better. If you have something that is significantly better than the previous agents you have a winner in your hands. I really believe we have something that has a lot of unique features.”

Merck KGaA had been developing the drug with partner Avillion and van Amstel’s team got in touch as soon as they heard the German pharma was considering selling it as part of a pipeline rethink.

Licensed in from Ablynx in 2013 five years before a merger with Sanofi, German Merck recognised its potential.

“There’s also a ‘mystery CEO’ that MoonLake has yet to unveil, who had the clout to get the deal across the line and begin exclusive negotiations once data had showed the drug’s potential”

  But it doesn’t fit in with a portfolio focused on cancer, neurogenerative diseases, fertility and endocrinology.

Ploos van Amstel’s plan allows it to be developed by a team of experts in the field while allowing Merck to get a return on its investment so far.

Not only did Ploos van Amstel begin talks before big pharma rivals got wind of the development, his team was able to put forward a potentially broad development plan that could include PsA, AS and HS as well as psoriasis.

Before moving to phase 3 MoonLake will likely plan phase 2 trials in PsA, AS and HS, which are relatively poorly served by other drugs, setting up a multi-pronged attack on the market if phase 3 trials go well.

The German pharma liked the strategy despite interest from other parties, which also took a stake in MoonLake as part of the licensing deal made possible with Series A financing led by BVF Partners.

There will also be milestone payments and “industry standard” royalties payable to Merck KGaA along the way.

Ploos van Amstel said: “Because we went broader there was a very attractive plan. It is in our and in Merck’s interest that it works as they are shareholders.

“I have worked for years and years in big pharma it is not always very fast. To the credit of Merck they chose us as partners. It’s a bold move and very calculated because we form a team that is very complementary.”

There’s also a “mystery CEO” that MoonLake has yet to unveil, who had the clout to get the deal across the line and begin exclusive negotiations once data had showed the drug’s potential.

“Myself, Kristian (Reich, Moonlake’s chief scientific officer) and the ‘third person’ made Merck believe we are the right people to deal with it.”

Looking forward Ploos van Amstel says the company may decide to develop sonelokimab in all four indications in parallel in phase 3.

That may depend on funding, trial results and whether a big pharma decides to partner with MoonLake in the future to help take the drug into late-stage development and launch it.

“It’s extremely possible a pharma company may want to partner and it can have many forms. It’s totally open but what we have to focus on is gettg the phase 2 trials showing that ‘IL-17 2.0’ is the future in inflammatory diseases.”

About the author

Richard Staines is the news editor for pharmaphorum and has been covering the pharma industry since 2010. His coverage has included stories about market access, the impact of the Greek financial crisis on the healthcare system and pharma pricing in the UK. Since joining pharmaphorum he has written stories on topics including regulation, mergers and acquisitions, and the latest clinical developments. Richard also contributes to pharmaphorum’s digital magazine, DeepDive.

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from https://pharmaphorum.com/views-and-analysis/inside-moonlakes-raid-on-merck-kgaas-inflammatory-disease-hopeful-sonelokimab/

[martynnx-blog]

Nanobodies Market: Factory Price and Marginal Revenue Analysis by 2026

Nanobodies are considered to be one of the best technology in the fields of research, diagnostics and therapy especially in cancer research. These technology was developed from antigen binding fragments, originating from Camelid heavy-chain antibodies. These molecules do not have light chains, which is an essential part of antibody found in humans. Based on the above finding, nanobodies molecule containing single-domain only were developed, and these molecules contain functional and structural properties similar to heavy chain antibodies. These molecules have several advantages as compared to the conventional antibodies such as small-size, nano to picomolar affinities, and multiple route of administration. Ablynx, which is acquired by Sanofi S.A., is one of the leading company in this market.

Nanobodies Market Drivers

Currently, no products are available in the market, but there are multiple products in the pipeline including few in very late stage of clinical trials. For instance, marketing authorization application for Caplacizumab for the treatment of acquired thrombotic thrombocytopenic purpura (aTTP) has been submitted to European Medicine Agency (EMA) in February 2017. The product, Caplacizumab, is expected to be launched in Europe in 2018. Moreover, the company, Ablynx, is expected to file for biologic license agreement to the U.S. Food and Drug Administration (FDA) in 2018, and is expected to launch this product in U.S. in 2019. Both, Europe and U.S. are the key markets for any biologics including monoclonal antibodies and are expected to be the high revenue generating market for nanobodies.

Nanobodies Market Key Players

Ablynx (now part of Sanofi S. A.) is the key player in the global nanobodies market. Moreover, the company is developing various products with leading biology companies such as Novo Nordisk A/S, Merck & Co., Inc., Merck KGaA, AbbVie, Inc., and C.H. Boehringer Sohn AG & Ko. KG.

Download PDF Brochure of This Business Report

[medicaldevicetech]

Global Custom Antibody Market -Size, Share and Research Report

Market Highlights:

The Global Custom Antibody Market is expected to register a growth of significant CAGR 9.6% during the forecast period (2018–2023). The custom antibody provides high specificity and selectivity, these are easy to produce as compared to other antibodies and are hence the preferred choice in all types of research studies. Rising geriatric population, growing R&D investment and number of drugs in the pipeline are further anticipated to fuel the market growth. Growth in this segment is mostly driven by the need for high-quality antibodies for research reproducibility and producing high-quality therapeutics.

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Segmentation:

The Global Custom Antibody Market has been segmented on the basis of service, source, type, research area and end users.On the basis of service, the market has been classified as antibody development, antibody production & purification, antibody fragmentation & labeling. The antibody development is segmented in to antibody characterization, antigen preparation, immunization & hybridoma production. On the basis of source, the market has been classified as mice, rabbits, human beings and others. On the basis of type, the market has been classified as monoclonal antibodies, polyclonal antibodies, recombinant antibodies, others. On the basis of research area, the market has been classified as oncology, infectious diseases, immunology, neurobiology, stem cells, cardiovascular diseases, other research areas. On the basis of end users, the market has been classified as pharmaceutical & biotechnology companies, hospitals and clinics, academic & research institutes, contract research organizations.

Regional Analysis:

The Americas is projected to lead the custom antibody market in the forecast period. Increasing healthcare awareness, advancement in technology, medical tourism are some other factors that boost the growth of the market. Also, growing investments in the progress of structure-based drug designs, growing focus on developing antibody-based therapeutics, rising research in the fields of genomics field, increasing demand for good quality research tools for data reproducibility and the existence of a huge number of global players in this region.

The European market is expected to hold the second largest market share. The market is expected to witness growth owing to the rising patient population, changing lifestyle, and growing elderly population. This is expected to provide favorable backgrounds for the market to grow. According to the Parkinson’s news today, the frequency of Parkinson’s disease in the U.K. is about 1 in 500 people, with a total of about 127,000 people living with the disease. According to Capra Science, a European company specialized in custom antibody production, llama-derived nanobodies might find therapeutic application in Parkinson’s disease.

Asia-Pacific is projected to be the fastest growing region for the global custom antibody in 2018. It is expected to witness profitable growth over the forecast period due to the existence of favorable healthcare schemes drafted by government agencies and growing research activities in the field of mAb-based therapeutics. Awareness programs and quality assurance of diagnostic procedures have added importance in the developing economies of Korea, Taiwan, China, Sri Lanka and India since the last few years.

The Middle East and Africa accounts for the least share due to stringent government policies and low per capita income.

Key Players:

Some of the key players in the global custom antibody market are Thermo Fisher Scientific Inc., Genscript, Abcam PLC, Merck Group, Bio-Rad Laboratories, Inc., Cell Signaling Technology, Inc., Agilent Technologies, Inc., Biolegend, Inc., Rockland Immunochemicals Inc., Promab Biotechnologies, Inc., Proteogenix, Innovagen Ab.

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Osteoarthritis Drugs Market   Outlook, Trend, Growth and Share Estimation Analysis

The global osteoarthritis drugs market is witnessing various innovations on the horizons such as rapid pain relieving injections and disease modifying drugs, thanks to growing cases of major illnesses like obesity. The global osteoarthritis is expected to witness a robust competition as the market landscape continues to be increase in fragmentation. Major players in the market are making large investments in reseach and development globally, finds Transparency Market Research (TMR). Some key players in the global osteoarthritis drugs market are Pfizer Inc., Horizon Pharma plc, Ferring B.V., Sanofi, Anika Therapeutics, Inc., Chugai Pharmaceutical Co., and Bioventus, Inc.  

The global osteoarthritis drugs market is expected to be propel forward in the near future, thanks to a growing awareness of diseases like degenerative bone disease, increasing R&D, and growing geriatric population as well. The pharmaceutical industry is growing through a tough phase as several key patents have expired. On the other hand, the industry is also faced with opportunities to reduce manufacturing costs considerably, due to advancements like 3D printing, several lucrative outsourcing opportunities, and prospects like Nano technology. This is expected to act as a catalyst for innovation in the industry with several firms already raising the bar with new drug developments and vital modifications in processes.

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The global osteoarthritis drugs market is projected to touch US$ 11,226.1 mn by 2026 end. However, due to patent expiry challenges and introduction of several generic versions driving down margins, the market is likely to expand at a single digit CAGR during the forecast period. Among various types of drugs in the market, the viscosupplementation agents are expected to dominate market growth, partly due to their high costs and partly due to growing demand for knee related arthritis treatments due to their effectiveness.

Growing Elderly Population a Major Driver of the Osteoarthritis Drugs Market

Osteoarthritis (OA) is an prevalent disease globally and it affects the elderly population quite severely. The condition is also life-threatening to many as it leads to impaired mobility leading to more potential accidents and financial constraints. However, the current crop of osteoarthritis drugs only offer pain mitigation and relief, but not a permanent solution. Additionally, osteoarthritis drugs also fail to halt disease progression. Hence, despite their lack of effectiveness and extreme high costs of viscosupplementation, the global osteoarthritis drugs market continues to grow. Moreover, the rising elderly population around the globe, and increasing reach of programs like Medicare in the US and privatized healthcare bill recently introduced in Australia, the osteoarthritis drugs market will result in several new opportunities for innovation.

Anti-Nerve Growth Therapy Promises a New Avenue for Growth

The global osteoarthritis market is witnessing several new product launches like increased investments, increasing prevalence of osteoarthritis due to growing obesity worldwide, and this has resulted in promising treatments like Anti- NGF treatments. NGF or Nerve Growth Factor is a promising therapy which can subside the progression of several arthritic conditions, and provides immense relief during chronic pain. Additionally, advent of other disease modifying osteoarthritis drug (DMOAD) also presents a new opportunity on the horizon. These drugs have proven to improve key functions like joints and promise to halt the progression of the disease as well. Nanobody is another promising treatment for arthritis.

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However, lack of seriousness in treating arthritis differently than conditions like old age is a major factor restraining the growth of the market. More awareness and more promising drugs can be major impetus for growth for the osteoarthritis drugs market in the near future.

Information provided in this review is obtained from a TMR report, titled, “Osteoarthritis Drugs Market (Drug Class - Corticosteroids, NSIADs and Others, Viscosupplementation Agents; Route of Administration - Oral, Parenteral, Topical; Distribution Channel - Hospital Pharmacies, Retail pharmacies, Online pharmacies) - Global Industry Analysis, Size, Share, Growth, Trends, and Forecast, 2018–2026”

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