#contract research organization boston

[organizeworkers]

Our Organizing Wins in 2023

Over the past year, EWOC had its busiest year yet with some truly extraordinary organizing wins. These include EWOC’s direct support in 14 successful union recognition wins and 15 more workplaces currently in a union drive. We’ve also connected 65 workplace campaigns and represented more than 7,000 workers to outside unions.

Growth in 2023

EWOC has also supported workers in

Taking one form of collective action at 447 workplaces

Winning demands at 47 pre-union workplaces

Marching on the boss at 17 workplaces

Striking at two workplaces

EWOC accomplished these wins by mobilizing our volunteers in 2023

200 EWOC volunteer organizers supported worker organizers

67 EWOC volunteers made worker intake calls, guaranteeing that every worker who reached out to us received a call within 48 hours

75 EWOC volunteers took on the role of support organizers. These are typically organizers with decades of experience, who mentor younger organizers working on EWOC campaigns.

Our 2023 Campaigns

These are some of the incredible stories from campaigns in 2023.

Residents at Beth-Israel Deaconess hospital in Boston ran a petition campaign with support from EWOC volunteers. That campaign garnered a supermajority of signatures in less than a week, and management conceded to the overwhelming pressure. They won a $10,000-per-year housing stipend and additional benefits for the 700 residents on staff.

Twenty-six workers at a Juiceland warehouse in Austin, Texas, won a $2-per-hour pay increase after marching on their boss.

Workers at The Basement, an escape room in Los Angeles, worked with EWOC volunteers to learn the foundations of organizing. They then went on to work with Actors Equity and become the first unionized escape room in the U.S.

In New York City, workers at Hex&Co., a gaming cafe, worked with EWOC volunteers for more than a year to develop organizing skills before connecting with a union. Their successful union drive with Workers United sparked a wave of game store union organizing across New York City. Two more stores have since announced union drives.

In Princeton, New Jersey, 19 workers at Labyrinth Books, an independent bookstore, are unionizing with the Retail, Wholesale and Department Store Union (RWDSU) after working with EWOC for over a year to develop their organizing skills.

Workers at Barboncino in Brooklyn worked with EWOC volunteers one-on-one over the course of many months. They learned and applied their organizing skills to become the first unionized pizzeria in New York City. Leaders from this campaign have even become organizing volunteers with EWOC. They use their experience and skills to support other service workers interested in organizing across the city.

2023 Special Events

In addition to EWOC’s organizing support, we had a record year of training. About 480 workers participated in our foundational training program. This four-week program runs six times a year at no cost to participants. We also put on two “Train the Trainers” events, growing from 10 to 55 foundational program facilitators. This has greatly helped expand our capacity to support workers interested in our training.

In 2023, EWOC launched a fellowship program designed as a follow-up to the foundational training, specifically for workers engaged in ongoing workplace campaigns. Participants were invited to apply with their co-workers. We welcomed 49 participants split into four cohort sessions, each lasting six weeks.

EWOC also put on a number of events in 2023. We discussed many labor topics, including salting, corporate research and power mapping, the Cemex decision, and organizing in remote workplaces. Jane MacAlevey joined EWOC for training on winning a first contract, and members of UAWD and TDU came to speak about the power of strikes and contract campaigns. Adam Conover attended an EWOC volunteer call and gave us a shout-out on his show.

In 2023, EWOC released a 26-part video series entitled “Unionizing 101.” These short videos were designed to make unionizing accessible and fun. They broke down core organizing questions like leader identification, power mapping, and more! These videos have more than 6,000 views on YouTube alone.

[jobaaj]

A career in management consulting can be both challenging and rewarding, as it involves helping organizations solve complex problems and improve their overall performance. Management consultants work with a wide range of clients, from large corporations to small businesses, non-profit organizations, and government agencies. If you're considering a career in management consulting, here are some key aspects to consider:

Roles and Responsibilities: Management consultants are hired to provide objective advice and expertise in various areas of business. Their responsibilities can include analyzing data, conducting research, developing strategies, implementing changes, and advising clients on organizational improvements. Consultants may specialize in different industries or functional areas such as strategy, operations, finance, human resources, IT, or marketing.

Qualifications and Skills: A strong educational background is often required for entry into management consulting. Most firms prefer candidates with at least a bachelor's degree, and many consultants hold advanced degrees (e.g., MBA, MSc, or Ph.D.). In addition to formal education, consultants need excellent analytical, problem-solving, and communication skills. They should be able to work well in teams and be adaptable to various working environments.

Industry Knowledge: Management consultants often need to understand specific industries and sectors they work in. Gaining expertise in a particular field can help you stand out and be more effective in your consulting engagements.

Consulting Firms: There are several well-known management consulting firms with global reach, such as McKinsey & Company, Boston Consulting Group (BCG), Bain & Company, Deloitte, PwC, EY, and others. These firms offer diverse opportunities for consultants to work on a wide range of projects and industries.

Travel and Work-Life Balance: Management consulting often involves travel, especially for client engagements. Depending on the firm and project, consultants may spend a significant amount of time on the road or at client sites. This can impact work-life balance, so it's essential to consider how much travel you are comfortable with.

Career Progression: A career in management consulting can offer a well-defined progression path. Consultants typically start as analysts or associates and can advance to senior consultant, manager, and ultimately, partner or director level. Alternatively, some consultants may choose to transition into industry roles after gaining experience.

Impact and Learning Opportunities: Management consultants have the opportunity to work on high-impact projects that can shape the future of organizations. The job also provides continuous learning opportunities as consultants tackle diverse challenges across various industries.

Demand and Job Market: The demand for management consultants can fluctuate based on the economic climate and the specific needs of industries. Consulting firms may go through periods of expansion or contraction, affecting job availability.

Entrepreneurial Opportunities: Experienced consultants may choose to start their consulting firms or join boutique consulting companies to focus on specific niches or industries.

Overall, a career in management consulting can be intellectually stimulating and provide exposure to various business environments. It's essential to research different firms, understand their areas of expertise, and network with professionals in the industry to make an informed decision about pursuing this career path.

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[marketresearchinfi]

Global Market Analysis of Biopharmaceutical Analytical Testing Services 2024-2028

Originally posted by Technavio : Biopharmaceutical Analytical Testing Services Market Analysis North America, APAC, Europe, South America, Middle East and Africa - US, China, Japan, UK, Germany - Size and Forecast 2024-2028

The biopharmaceutical analytical testing services market is poised for significant growth, with projections indicating an increase of USD 3.45 billion and a compound annual growth rate (CAGR) of 12.61% from 2022 to 2027. This expansion is driven by various factors, including the rising demand for monoclonal antibodies (mAbs), the increasing prevalence of chronic diseases, and advancements in biopharmaceutical R&D.

Click here for the sample report

Market Dynamics

Key Drivers:

Rising Demand for Monoclonal Antibodies (mAbs):

Importance in Immunotherapy and Personalized Medicine: Monoclonal antibodies are critical in treating various conditions, necessitating rigorous quality control tests such as microbial, sterility, and dissolution tests.

Patent Expirations: The expiration of drug patents further increases the need for mAbs, requiring extensive biopharmaceutical analytical testing to ensure drug safety and efficacy.

Increased Investment in R&D:

Global R&D Expenditure: Rising global expenditure on R&D, especially in developing countries, is leading to the establishment of new laboratories and research facilities.

Support for Analytical Testing Services: This trend bolsters the demand for analytical testing services, essential for developing new biopharmaceutical drugs.

Significant Trends:

Expansion of Bioanalytical Services:

Dominance of Bioanalytical Services: The use of biosimilars for conditions like diabetes and cancer drives the market, with pharmaceutical companies increasingly outsourcing R&D activities to focus on core competencies.

Increased Outsourcing: The growing trend of outsourcing R&D to specialized service providers boosts demand for bioanalytical services.

Technological Advancements:

Enhanced Accuracy and Speed: High-throughput screening methods, automation, and advanced analytical techniques improve the precision and speed of bioanalytical testing.

Innovation in Therapies: These technological advancements support the development of innovative therapies and combination products.

Major Challenges:

Shortage of Skilled Professionals:

Specialized Skills Deficit: The market faces a significant challenge due to the shortage of trained professionals with specialized skills in biopharmaceutical analytical testing.

Impact on Compliance and Quality: This shortage leads to high non-compliance rates, impacting product quality and manufacturing processes.

Market Segmentation

By Service:

Bioanalytical: Leading segment with applications in bioavailability, pharmacology, bioequivalence, pharmacokinetic, and toxicology studies.

Method Development and Validation

Stability Testing

Others

By End-User:

Pharmaceutical Companies

Biotechnology Companies

Contract Research Organizations (CROs)

By Geography:

North America: Contributing 33% to market growth, driven by key companies like Charles River and Catalent, and significant R&D investments.

Europe

Asia

Rest of the World (ROW)

Regional Insights

North America:

Strong R&D Infrastructure: The presence of major companies and a robust R&D infrastructure supports market growth.

High Investment in Clinical Trials: Significant investments in clinical trials and research studies to address the rising prevalence of diseases drive demand for analytical services.

Europe and Asia:

Establishment of Research Facilities: Increasing establishment of research facilities and laboratories fuels market growth.

Focus on Innovation: The growing pharmaceutical industry and emphasis on innovation boost demand for analytical testing services.

Competitive Landscape

The market is fragmented, with key players including:

Almac Group Ltd.

Boston Analytical

Catalent Inc.

Charles River Laboratories International Inc.

Eurofins Scientific SE

Intertek Group Plc

SGS SA

Thermo Fisher Scientific Inc.

West Pharmaceutical Services Inc.

Conclusion

The biopharmaceutical analytical testing services market is set for substantial growth, driven by increasing demand for mAbs, robust R&D investments, and technological advancements. However, addressing the shortage of skilled professionals remains a critical challenge. The market's expansion will be supported by the development of innovative therapies and the continuous evolution of biopharmaceuticals, ensuring the safety and efficacy of new drugs.

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[blockgeni]

In 2024, the rate of advancement and adoption of artificial intelligence (AI) in our daily lives will further quicken. AI will grow more pervasive in everything we do as businesses figure out how to maximize its potential, people utilize it to increase their productivity, and policymakers scratch their heads over how to regulate it. Hopefully, by 2024, we will have made progress towards resolving some of the sticky concerns surrounding this technology. Though costs and convenience of use have reduced entrance barriers in recent years, there are still issues of trust, bias, accessibility, and regulation. Focusing on these issues could put us on pace to realize AI's full potential as we enter the second half of the decade. The chatbots and image generators that astounded and at times frightened us in 2023 will be far outdone by the next generation of generative AI technologies. Creators of generative music and video are already emerging, and they'll only get stronger and easier to use. They will begin to be included into productivity software and creative platforms, much like ChatGPT technology this year. Applications such as voice synthesizers and generative design tools will emerge and be intriguing. An increasingly important item in the essential skills toolkit will be the ability to distinguish between the genuine and computer-generated! Ethical AI Because AI has the potential to be so disruptive, it is crucial that it be created and deployed in a responsible manner that reduces its ability to harm. The potential to replace human occupations, bias, a lack of transparency, and our inability to guarantee with absolute certainty that it will never spiral out of control are just a few of the risky elements that we already know about. We will see a continuous emphasis on minimizing these issues and remaining watchful for brand-new ones in 2024. As companies appear to show that they are upholding ethical standards and implementing necessary protections, demand for AI ethicists will rise. Customer Service Using AI In some corporate activities, such as customer service, a lot of repetitive, ordinary jobs are intermingled with occasionally extremely difficult and crucial ones. This makes it a perfect testing ground for incorporating AI into operations, automating the tedious to free up time for problems that require human interaction. Initial contact calls can be prioritized using AI, and it can also produce reports and summaries of client interactions as well as personalized solutions to common problems. According to a Boston Consulting Group poll, 95% of customer service executives believe AI bots will assist them in serving consumers at some point in the upcoming three years. Augmented Working The ability to boost human intelligence and capacities in order to complete tasks more quickly, effectively, and securely will be a crucial workplace competency in 2024. It will assist you in summarizing pertinent case law quickly if you are a legal whiz, or it will hasten the drafting of contracts. It will be used by doctors to help them write up patient notes or medical photos. It will be used by programmers to write software more quickly and to test and troubleshoot its output. If you're a student, it can assist you in organizing your notes and research, and if you're unemployed, it can assist you in creating cover letters and your CV. AI-Augmented Apps This year, everyone hurried to incorporate generative AI features into their programmes and applications. Adding chatbot capability is proving to be a successful method for fostering the next-generation of customer experience across a variety of platforms, including search engines like Bing and Google, productivity applications like Office, social media apps like Snapchat, and industry-specific ones like Expedia (travel) and Coursera (education). Due to concerns about data security and consumer privacy, service providers may have been reluctant to offer

their services, but as AI providers modify their services to match market demands, these concerns should start to be alleviated. To allay concerns that copyright and ownership may become an issue in the future, Adobe has included generative AI into its Firefly creative tools. This AI was trained exclusively on proprietary data. Low-Code And No-Code Software Engineering Gartner anticipated that by 2024, low-code/no-code technologies would be used for 65 percent of application development. Given that anyone can design and test applications in only a few minutes thanks to generative AI tools like ChatGPT, this may very well prove to be true. Although coding or software engineering employment is not going away in 2024 (after all, someone has to create the AI tools), there will be plenty of intriguing opportunities for those with brilliant ideas and a passion for problem-solving but fewer specialised technical abilities. AI Jobs The good news is that a slew of new employment opportunities will be opening up in 2024 that might be suitable for you if you want to work in AI but aren't interested in becoming a computer scientist. Jobs for prompt engineers, who write the instructions that tell AI programmes what to do, and AI managers, who manage groups of virtual employees, will become available in addition to the engineers and technicians needed to build systems. AI trainers, project managers, and ethicists will likewise be in more demand. On the other side, if you are a techie, there will be lots of new jobs for you as well in professions like AI engineering and DevOps. Quantum AI Undoubtedly, this tendency won't immediately have an impact on everyone. But quantum computing, which has the power to dramatically accelerate some computation-intensive jobs, is rapidly being found to have uses in AI. In contrast to ordinary computer bits, which can only ever be 1 or 0, quantum algorithms analyze data using qubits, which could exist in more than one state at a time. This is one of the characteristics that makes them significantly more effective than traditional algorithms for issues like optimization, which is a common machine learning problem that involves finding the optimum combinations of numerous variables. In order to power ever-larger and more complicated neural networks and algorithms, we can anticipate seeing more advancements in the application of quantum computing throughout 2024. Upskilling For The AI Revolution Nowadays, it's often argued that AI won't take jobs, but that those who use it will steal them from those who don't. Understanding how AI affects your own job or trade and mastering the skill of matching the appropriate tool to the task are really smart moves if you want to advance. Employers with an eye towards the future will do their best to support their workforces during this transition by incorporating AI expertise into curriculum and training initiatives. If yours isn't, there are a tone of options online, most of which are free. So get started now and you'll soon be able to discover a far better employer! AI Legislation Legislators have always struggled to keep up with technology, but the unmistakably revolutionary nature of AI is starting to get their attention. China already has rules in place, one of which forbids the creation of non-consensual deepfakes. Additionally, a number of jurisdictions, like the US, India, and the EU, are creating their own sets of rules. The UK has proposed legislation that might go into effect in 2024, while an EU act is anticipated to be in place at the beginning of 2025. Each piece of law will aim to strike a compromise between safeguarding individuals from AI's potentially harmful effects on jobs and privacy, for example, and promoting innovation and trade. Politics in 2024 are anticipated to focus heavily on the discussion over where the borders should be drawn. Source link  

[ecardon1]

Hospital at Home-An Idea Whose time has Come

Long before fears of infection from the coronavirus made people wary, hospitals were often not the best place to be treated and recover. Awareness of the risks of infections and the debilitating impacts of hospital stays, particularly on patients who are frail, have cognitive impairments, or other vulnerabilities, prompted Johns Hopkins University, to establish the first hospital-at-home program in the United States 20 years ago.

The model, which offers people who would typically require hospitalization to treat problems such as acute pneumonia, dehydration, or exacerbations of conditions like heart failure or chronic obstructive pulmonary disease (COPD) the option of receiving acute-level care in their homes, has been one of the most studied health care delivery reforms.

In recent years, a handful of U.S. health systems have launched similar programs, either because their hospitals are operating at capacity and/or they’ve taken on financial risk for the total costs of patients’ care and thus benefit from delivering services in a lower-cost setting. The Veterans Health Administration, which controls both payment and care delivery, has funded its own hospital at home program as have some health systems that have their own health plans and/or substantial numbers of patients in accountable care organizations or managed care plans.  

Several startup companies now offer logistical support and technology to facilitate hospital-at-home programs, as well as help contracting with commercial payers. Broader spread, however, has been stymied by the fact that Medicare does not pay for acute services provided outside of hospitals for fee-for-service beneficiaries.

As in so many parts of health care, the COVID-19 pandemic has catalyzed change: not only has it created a clear rationale for avoiding hospitals when possible, it has prompted Medicare to allow providers to bill for acute treatments delivered in surgery centers, hotels, or other non-hospital facilities. Some are hoping waivers tied to the Hospital Without Walls initiative will open the door for Medicare to pay for acute care in homes, too.

Several large hospital systems have begun their own hospital at home programs:

Mount Sinai Health System (NY)- Mount Sinai Health System launched a hospital-at-home demonstration in 2014, funded by a $9.6 million grant from the Center for Medicare and Medicaid Innovation. Leaders were drawn to the model as a way to relieve pressure on their inpatient wards, which even before the pandemic were routinely filled beyond capacity.

After the three year Medicare funded project ended Mount Sinai in 2017 set up a joint venture with Contessa Health, a Nashville-based startup launched in 2015 whose founders sought to make home hospitalizations financially sustainable by contracting with health plans willing to pay for them, namely Medicare Advantage plans, Medicaid managed care plans, and commercial health plans.

Tufts Medical Center (MA)- Like Mount Sinai, Tufts Medical Center in Boston was bursting at the seams, pre-COVID-19; it routinely had to turn down requests to accept patients from other hospitals because no beds were free. To help expand access, leaders had begun partnership discussions with Medically Home, another hospital-at-home company founded in 2017 after eight years of research and development. 

Medically Home partners with its clients’ clinicians and also hires physicians and nurse practitioners, who work from a central hub from which they use remote monitoring, video, and other telehealth tools to oversee patients’ care. They confer with Tufts Medical Center’s attending physicians to make sure patients are good candidates for the program. Advanced practice providers, paramedics, nurses, phlebotomists, technicians, therapists, and other staff visit acutely ill patients in their homes, providing infusion, lab tests, imaging, nutrition, translation, and other services. 

Medically Home draws on its health system partners and community resources, including local paramedics and equipment suppliers, to build a virtual hospital. 

Home-based models that offer coordinated episodes of care — including for emergent, acute, and post-acute needs — could be of particular benefit to patients who have frequent emergency department visits or hospitalizations.

CMS’s Hospital Without Walls initiative could provide a means by which hospitals can provide some care in homes, but it’s unclear how long the waiver will remain in place. To qualify as acute care, hospital providers need to deliver home services themselves and must deliver a certain level of services (e.g., oxygen, durable medical equipment, radiology, and meals).

In the short term, spread of the model may depend on the course of the coronavirus and hospitals’ desires to prepare for potential surges. In the longer term, it may find broader interest if value-based payments gain broader traction.

Ed Cardon

EPC Search International LLC

470-345-0846

ed@epcsearchinternational.com

[chemicaltech]

Pharmaceutical analytical testing outsourcing Market is set for lucrative growth during 2021-2031

Pharmaceutical analytical testing outsourcing is the transfer of analytical testing operations for a pharmaceutical product from the company that manufactures the product to an external provider. The external provider may be a contract research organization (CRO), a contract testing laboratory (CTL), or another type of organization that specializes in analytical testing services. The decision to outsource analytical testing is typically made when the company does not have the internal resources or expertise to perform the testing required for a particular product.

There are several benefits to outsourcing analytical testing, including access to specialized expertise, cost savings, and increased efficiency. In addition, outsourcing can help to ensure that testing is performed in a consistent and reliable manner. When selecting an organization to outsource to, it is important to consider the organization’s experience, capability, and reputation.

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Market Segments

The pharmaceutical analytical testing outsourcing market report is bifurcated on the basis of product type, service, end-user , and region. On the basis of product type, it is segmented into active pharmaceutical ingredient (API), additives, and finished products. Based on service, it is analyzed across bio analytical testing, method development & validation, stability testing, and others. By end-user, it is divided into biopharmaceuticals, pharmaceuticals, contract manufacturing organizations, and others. Region-wise, it is studied across North America, Europe, Asia-Pacific, and rest of the World.

Key Players

The pharmaceutical analytical testing outsourcing market report includes players such as Bioreliance, Boston Analytical, Eurofins Scientific, Exova, Halo Pharma, Intertek Group PLC, SGS SA, Toxikon, Inc., WuXi AppTec, Inc., and Catalent, Inc.

Key Drivers

The outsourcing of pharmaceutical analytical testing is driven by a number of factors, including the need for cost savings, the desire to focus on core competencies, and the availability of specialized testing services.

The pharmaceutical industry is under pressure to reduce costs and increase efficiency. Pharmaceutical companies are looking for ways to reduce their operating costs, and one way to do this is to outsource non-core functions such as analytical testing. Analytical testing is a complex and time-consuming process, and it is often more cost-effective to outsource this function to a specialized provider.

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[boopathi021]

7 top technologies required for the development of the Metaverse?

How can the 3D virtual world become reality?

The Metaverse is a nascent and ever-evolving virtual space, and its definition varies widely among different people.

The challenge for Metaverse development right now is to compile a comprehensive and solid list of technologies that will help the Metaverse thrive over the next decade.

“We don’t think of the metaverse itself as a specific set of technologies, because it’s made up of multiple technologies,” said Gartner vice president analyst Marty Resnick. “We can think of it as a technology theme.”

At the same time, he believes that spatial computing, digital humans, virtual spaces, shared experiences, games, and tokenized assets all belong to these themes, and they contain a series of technologies that help to enhance the development of the metaverse.

Likewise, Forrester Research describes these types of technologies as “enablers of 3D development environments” that enable complex modeling, according to JP Gownder, vice president and principal analyst.

As such, he explained, organizations will need professionals who are proficient in 3D modeling and familiar with Unity and the Unreal game engine. Other required skills will depend on what is being programmed, e.g. IoT skill set for digital twins .

“Most organizations don’t have these abilities at the present time,” Gownder noted, “so they need to work with outer gatherings or enroll important specialized ability.”

Jason Warnke, senior managing director and global head of digital experience at IT consultancy Accenture, added that the technologies underpinning the metaverse, from game engines to digital twins to extended reality, are merging in new ways to solve real-world problems. .

The Boston Consulting Group (BCG) “Hitchhiker’s Guide to the Metaverse Enterprise” specifies the following three categories of technologies that define the Metaverse:

Virtual worlds (M-worlds);

Augmented Reality (AR), Virtual Reality (VR) and Mixed Reality (MR); Web3 and virtual assets.

Among them, M-worlds is an immersive application that can provide companies with new ways to reach audiences, especially Gen Z users. M-worlds can run on mobile devices as well as PCs and AR/VR headsets.

Web3 is in its early stages, but according to the authors of the BCG Guide, “Web3 is already powering a vibrant virtual asset economy, including Crypto, non-fungible tokens, and smart contracts.”

The counseling firm expects Web3 and Customary monetary exchanges will coincide for years to come .

In fact, the authors also state that “most of the value of the metaverse may ultimately lie not in consumers but in business applications.” These applications may include virtual conferences, training sessions, new product designs, and virtual house tours for potential customers.

Based on expert opinion and extensive research, we were able to narrow the list down to the seven most frequently mentioned technologies that will help drive the Metaverse and its development.

◉ Artificial intelligence

Artificial intelligence plays a central role in the development of robots and chatbots, bringing intelligence to real-world computer vision. However, according to BCG, only 10 percent of companies reported significant AI benefits from their deployments.

The processing power of artificial intelligence can create virtual avatars, enhance the characteristics of digital humans to make them more lifelike, and can be applied to non-player characters who talk to players in game environments.

◉ Internet of Things

The Blockchain Council calls the Internet of Things “a vital pillar of the Metaverse’s infrastructure.” For example, the committee report states that integrating the Metaverse and the Internet of Things could “unlock new opportunities for industrial domains, individual needs, and societal needs.”

IoT will allow virtual spaces to seamlessly access and interact with the real world, while Metaverse will provide 3D user interfaces for clusters of IoT devices, resulting in what the council calls a “user-centric IoT and Metaverse experience”.

For example, in a factory where the digital twin of each machine has sensors, the sensor data can be used to explore the environment and provide feedback.

◉ Extended Reality

AR, VR and MR technologies will change the way businesses visualize and use data by moving from 2D to 3D for more lifelike experiences and digital displays that better synchronize with head movements, BCG said.

When AR glasses become more mainstream, computer vision will help people understand the environment and locate the correct information. And extended reality (XR) is already being used in, for example, Microsoft’s HoloLens, allowing users to experience 3D holographic images.

◉ Brain Computer Interface

The World Economic Forum (WEF) has included the brain-computer interface (BCI) in its list of technologies that will shape the Metaverse, with WEF acknowledging that BCI may be the most far-reaching vision for the Metaverse, as the technology aims to replace traditional control screens and physical hardware . At the same time, WEF also pointed out that the combination of BCI and XR will be positioned as the next computing platform.

◉ 3D modeling and reconstruction

3D reconstructions capture the shape and appearance of real objects and bring the Metaverse to life. The technology includes tools such as 3D modeling to provide 3D frameworks and prototypes of specific processes or products.

According to a report by SkyQuest Technology Consulting, in the long run, the global 3D reconstruction technology market is expected to double in the next few years, reaching approximately $2 billion by 2028.

◉ Space and edge computing

Spatial computing combines AR, VR, and MR to interact with the real world. Edge computing can provide fast response time for user actions that mimic reality, allowing users to immerse themselves in the metaverse. Any kind of space technology, including computer vision, is closely related to the Metaverse.

◉ Blockchain

Today, Gownder said, blockchain doesn’t seem to have much to do with businesses and their employees.

However, there is currently a lot of discussion focused on how to use blockchain technology to protect digital content and data in the Metaverse. Blockchain can make the Metaverse Technology more decentralized and avoid some delays or single points of failure.

[fumpkins]

How pathogenic gene variants lead to heart failure -- LiveScience.Tech

Cardiomyopathy is not a uniform disease. Rather, individual genetic defects lead to heart failure in different ways, an international consortium reports in Science.

The molecular and cellular mechanisms that lead to heart failure in people with cardiomyopathy are determined by the specific gene variant that each patient carries, according to newly published research based on the first comprehensive single-cell analysis of cardiac cells from healthy and failing hearts.

The work, reported in the journal Science, was conducted by 53 scientists from six countries in North America, Europe, and Asia.

The study shows that cell type compositions and gene activation profiles change according to the genetic variants. The investigators say the findings can inform the design of targeted therapies that take into account each patient’s underlying gene defect responsible for their particular form of cardiomyopathy.

The team studied 880,000 single heart cells

Examining the genes activated in about 880,000 single cells from 61 failing hearts and 18 healthy donor hearts as reference was a complex endeavor which required an interdisciplinary team. The organs were procured by the Brigham and Woman’s Hospital in Boston, USA, University of Alberta in Canada, the Heart and Diabetes Center North Rhine-Westphalia in Bad Oeynhausen, Ruhr University Bochum in Germany and Imperial College London, UK.

Senior authors who spearheaded the project are Christine Seidman, professor of medicine and genetics at Harvard Medical School and a cardiologist at Brigham and Women’s Hospital; Jonathan Seidman, professor of genetics at Harvard Medical School; Norbert Hübner, professor of cardiovascular and metabolic sciences at the Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC) and Charité — Universitätsmedizin Berlin as well as Dr. Gavin Oudit, University of Alberta, Canada; Professor Hendrik Milting, Heart and Diabetes Center NRW, Bad Oeynhausen, Ruhr University Bochum, Germany; Dr. Matthias Heinig, Helmholtz Munich, Germany; Dr. Michela Noseda of the National Heart and Lung Institute at Imperial College London, UK and Professor Sarah Teichmann, Wellcome Sanger Institute in Cambridge, UK. Joint first authors are Dr. Daniel Reichart (Harvard), Eric Lindberg and Dr. Henrike Maatz (both MDC).

A disease with many causes

The scientists focused on dilated cardiomyopathy (DCM), the most common form of heart failure that leads to heart transplantations. It involves an expansion (dilation) of walls of the heart chamber, especially in the left ventricle, the heart’s main pumping chamber. The muscles of the heart become weakened, compromising its ability to contract and pump blood, which ultimately leads to heart failure. The consortium studied tissues from patients with different genetic mutations that commonly lead to cardiomyopathies. These mutations occurred in proteins with different functions in the heart and the analyses indicate that these triggered different responses.

“We investigated pathogenic gene variants in heart tissue at the single-cell level, which allowed us to map precisely how specific pathogenic variants drive cardiac dysfunction,” says co-senior author Norbert Hübner. “To our knowledge, this is the first such analysis conducted in cardiac tissue, and we hope this approach can be used to study other types of genetic heart diseases.”

The scientists precisely characterized the various mutations in each of the hearts and compared them with each other, as well as with healthy hearts and with hearts in which the causes of dilation and dysfunction were unknown. Each cardiac cell type and the numerous subtypes were analyzed one by one, using single-cell sequencing methods. No lab on its own could deal with the massive amount of data generated, but close collaboration among specialists from different disciplines made it possible to assemble a coherent picture out of each individual piece of the puzzle. This study is also part of the efforts of the international Human Cell Atlas (HCA) consortium, which is aiming to map every cell type in the human body as a basis for both understanding human health and for diagnosing, monitoring, and treating disease.

“Only this level of resolution allows us to see that cardiomyopathies do not uniformly trigger the same pathological pathways,” says co-senior author Christine Seidman. “Rather, different mutations evoked specific and some shared responses that lead to heart failure. These genotype-specific responses point to therapeutic opportunities that may inform the development of precision-targeted interventions,” Seidman says.

Hyperactive connective tissue cells

“For example, we discovered that fibrosis — the abnormal growth of connective tissue — observed in DCM is not caused by an increased number of fibroblasts in the heart,” says Matthias Heinig, who carried out computational analyses. “The number of these cells stays the same. But the existing cells become more active and produce more extracellular matrix, which fills in the space between the connective tissue cells,” Eric Lindberg adds. Thus, rather than overproduction of fibrotic cells, the researchers observed only a shift in the proportion cell subtypes, marked by an increase in the number of fibroblasts specializing in the production of extracellular matrix.

“The phenomenon was especially pronounced in the hearts of patients with a mutated RBM20 gene,” Henrike Maatz explains. This observation was also reflected in the patients’ medical histories. On average, patients with this specific mutation suffered heart failure and needed a transplant much earlier than people with other genetic forms of DCM. Single-cell sequencing revealed a whole series of such genotype-specific differences in dilated hearts.

Specific patterns of change

The analysis also showed that in the hearts of people with arrhythmogenic cardiomyopathies (ACM) — those that cause dangerous heart rhythm disturbances — muscle cells are increasingly replaced by fat and connective tissue cells, particularly in the right ventricle. Although this form of cardiomyopathy can also be caused by a mutation in several genes the team focused its analysis on the gene for the protein plakophilin-2, or PKP2 for short. They compared cell signaling pathways from cells obtained from the right and left ventricles. The findings identify the cause behind increased cell-fat production in the cardiac muscle of people with this type of cardiomyopathy.

“The precise molecular signatures obtained for the highly specialized cells of the heart allowed us to predict cell-to-cell communication pathways,” Michela Noseda says. The team found that different genetic causes of cardiomyopathies were associated with specific aberrations of the cellular communication networks. “This is clear evidence of specified mechanisms driving the disease.”

Finally, the scientists used artificial intelligence to develop a model from all these data. Based on the specific patterns of molecular changes in the various cell types, the algorithm can predict with high degree of confidence which mutation is present — confirming that differences in gene and cell activation are associated with pathogenic variants of specific genes.

Biomarkers for targeted therapies

The ultimate goal is to develop individualized therapies for heart disease the researchers said, because genotype-specific treatment could be more effective and with fewer side effects. The consortium has made all of its results available to the scientific community online. Seidman hopes that this resource propels studies by other groups to define new treatments that prevent heart failure, which today is an incurable disease.

“We investigated tissues of patients who needed a heart transplant; it was their last option,” Hendrik Milting says. “We hope that future pharmacological treatments will at least slow down the progression of the disease — and that the data from our study will help make this happen.”

Meanwhile, the research team has identified its next task. “The heart tissue that we studied came from people in the final stage of a disease,” Daniel Reichart, one of the first authors, says. “We are excited to see what changes we discover in earlier stages of disease, for example based on endomyocardial biopsies.” Perhaps biomarkers and pathways will be found that elucidate a very precise disease pathogenesis truly enabling personalized medicine, Gavin Oudit adds.

New post published on: https://livescience.tech/2022/08/05/how-pathogenic-gene-variants-lead-to-heart-failure-livescience-tech/

[healthcare-domain]

Increasing Preference For Aspiration Needles Market

COVID-19 led to a significant drop in imaging procedures since March 2020 (for all modalities). A late resurgence of imaging throughput was observed in the second half of 2020; however, the overall throughput remained at a level of roughly 80% of the baseline volume for the entire year. In April 2020, the US FDA issued a guidance to provide a policy to help expand the availability and capability of medical X-ray. 

The repercussions of delayed cancer detection owing to COVID-19 were investigated in a study undertaken in the UK and published in Lancet Oncology in March 2021. The study covered data from over 100,000 people with breast, colorectal, esophageal, or lung cancer. It found that 1- and 5-year cancer survival rates will be severely reduced because of the outbreak of COVID-19, owing to the reduction in diagnostic biopsies and lack of availability of screening services. 

However, numerous physician reports from the US have observed a growing number of screening appointments during the last quarter of 2020, which is expected to rise continually. 

Download PDF Brochure @ https://www.marketsandmarkets.com/pdfdownloadNew.asp?id=71036825 

[203 Pages Report] The global aspiration and biopsy needles market is valued at an estimated USD 879 million in 2021 and is projected to reach USD 1,303 million by 2027, at a CAGR of 6.8%. Factors such as the rising prevalence of cancer, initiatives undertaken by government and global health organizations, and the increasing preference for minimally invasive procedures are the major factors driving the growth of the aspiration and biopsy needle market. 

Globally, there has been a significant increase in the number of people suffering from cancer. This can be attributed to a number of factors, such as lifestyle changes, unhealthy diets, and increasing tobacco consumption.  

According to estimates from the International Agency for Research on Cancer (IARC), in 2018, there were 17.0 million new cancer cases and 9.5 million cancer deaths worldwide. By 2040, the global burden is expected to grow to 27.5 million new cancer cases and 16.3 million cancer deaths, primarily due to the growth and aging of the population. 

Biopsy needle procedures, such as core-needle and fine-needle procedures, assist radiologists and surgeons in examining abnormalities at a particular site. However, patients can contract infections during these procedures as they involve cuts and incisions for removing tissue samples. Also, in several cases, aspiration and biopsy needles are reused, which further increases the risk of infection during these procedures.  

With the growing awareness about different types of cancers, the demand for biopsy procedures is expected to increase in the coming years. However, there is a dearth of skilled surgeons to perform minimally invasive biopsy procedures. For instance, a shortage of more than 2,300 medical oncologists is expected in the US by 2025 (Source: Journal of Global Oncology). 

CONMED Corporation (US), Medtronic Plc (Ireland), Olympus Corporation (Japan), Becton, Dickinson and Company (US), Boston Scientific Corporation (US), Cook Group Incorporated (US), Argon Medical Devices, Inc (US), INRAD Inc. (US), Somatex Medical Technologies (Germany), Stryker Corporation (US), Cardinal Health (US), Remington Medical (US), Ranfac Corporation (US), HAKKO CO., LTD (Japan), and Merit Medical Systems (US) are some of the major players in the aspiration needles market.

[yokeproductions]

Yoke Productions - Production Services for Photography, TV & Commercials.

WHAT WE DO ? We offer full service production services to film , tv, commercials & photography on the Island of Ireland. Established since June 2000, our principle goal is to offer a cost effective means of producing Print, Commercials, Film & Television in Ireland. We have also produced numerous projects overseas including; USA (NY, Boston , LA, Montana), UK , Spain and France. We will cater for all your production requirements from Casting to Craft Service, Equipment Hire to Accommodation, Location Scouting to Management, we make it our business to look after you. We offer full service production for film , tv, commercials & photography. Services include, but are not limited to, research; consulting; production management and coordination; budgeting; scheduling; negotiating contracts; casting; location research, scouting and management; handling of permits and insurance; hiring of crew renting studios and equipment; arranging catering; organizing travel itineraries and ground transportation/logistics; and final invoicing.

[sellfurnitureonline]

Online Classifieds Auto Buys And Sells Services

Several online auto buying services have popped up over the last few years This service has been providing quality used different products for the local areas in the whole world. Auto buying service can help the people to get a better price on the products that they want, without having to haggle generally, either an employee of the service will directly negotiate for you or the service will have worked out exclusive deals with specific products dealership beforehand in short by using this service people are able to get the product that they want at a reasonable price without the stress many organizations offer online car sale or buying services to their members for free so if you belong to any of these organizations then see what they are willing to do for you when you purchase your next product so for this purpose keep in mind ,however that because the following services are free people may not get as low of a price as the people could from a service with more personalized support.

Another method which is very common in the whole world that is going directly to the internet sales manager at a dealership is often a good way to get a better price but it can be annoying to keep track of and compare all offers, however, will contact dealerships for the people and help them to determine that which offer is the best one. A dealership that provides an offer can also see other offers as well which encourages competition and a better price for you .But today's ready accessibility to the internet ,auto buying and research have never been easies . Cars Direct is an American online automotive research portal and car buying service based in El Segundo, California that allows consumers to research, price, and purchase, insure and finance a vehicle online. The company also provides lead generation and referral services to auto dealers. Cars Direct founded in 1998 by Scott Painter, launched from the business incubator Idea lab. It was the first company to Auto buys and sells directly to consumers, rather than referring consumers to brick and mortar dealers.

If you buy a service contract from the dealer within 90 days of buying a used vehicle, federal law prohibits the dealer from eliminating implied warranties on the systems covered in the contract. For example, if you buy a car as the car normally is not covered by implied warranties. But if you buy a service contract covering the engine, you automatically get implied warranties on the engine. These may give you protection beyond the scope of the service contract. Make sure you get written confirmation that your service contract is in effect. For more information please visit: www.adsthumb.com

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[superramkrishna-blog]

Data Analyst(Heath Care)

Job Title:     Data Analyst Location:     Boston,MA  Duration:     Long Term Contract. Exp: 10+ Years US Healthcare experience is mandatory. Mandatory Skills: Data Analysis, data documentation, Data Profiling. Responsibilities This role is responsible for developing, preparing, and maintaining quality data analytics that will be utilized by leadership and management across various settings and promote new opportunities for the organization. Review requirements and analyze. Responsible for data documentation and reviewing. Responsible for data profiling and data analysis. Responsible for preparing data mapping documents. The Data Analyst leverages its advanced knowledge of data, modeling, optimization, and tools. Applies disciplined analytics to predict behavior and optimize programs and products to maximize revenue growth. Understands and analyzes complex data, articulates to various units within the company at the appropriate level, impacts the business. Requirements 5+ years’ experience as Data Analyst or Business data analyst. US Healthcare experience is mandatory. Experience in FACETSsystems is mandatory. Technical expertise regarding data models, database design development, data mining and segmentation techniques. Preferred technologies such as SAS, SQL, R, Python, Tableau, Hadoop, or similar tools. Data Interpretation skill. Strong analytical skills with the ability to collect, organize, analyze, and disseminate significant amounts of information with attention to detail and accuracy. Excellent in SQL, Excel, Analysis. Should have a very good understanding of data, tables, relations. Ability to use appropriate problem solving, research and analysis tools + Experience with data mining, predictive modeling techniques and using data to drive business outcomes and decisions + Strong attention to detail +Comprehensive knowledge of all Microsoft Office applications + Excellent written and verbal communication Must be passionate about contributing to an organization focused on continuously improving consumer experiences.   Thanks & Regards Shruteesh Kumar Talent Acquisition Specialist  Office: +1 732-725-0458 Email: shruteesh@wbsolutions.com Read the full article

[bostoncontemporaries]

Senior Assistant at a University in Boston

Our University client in Boston is looking for an experienced Senior Assistant to provide administrative support to a University's school and center. This full-time role is initially hybrid but will transition to full-time in the office. This contract role is a potential temp-to-perm opportunity.  Responsibilities include (but are not limited to): Manage all administrative office services and project workflow for 25+ full-time/part-time faculty, and graduate assistants providing continuity of support for group teaching and research endeavors. Learn and use computer information systems and software necessary to support center faculty. Provide office environment responsive to student needs by having thorough knowledge and understanding of department and University policies and procedures. Provide positive student interaction. Provide for the secure maintenance of all sensitive and confidential materials; coordinate department effort in the security of premises, keys, equipment, exams, etc Provide administrative support to Group Coordinator managing all aspects of operations. Manage Group operating budget and Procurement Card expenses. Assist with faculty recruiting effort; coordinate faculty candidate visits arranging the schedule of interviews with faculty and deans; communicate with the candidate to confirm times and set itinerary; supply faculty and the candidate with pertinent materials for day of the visit; schedule luncheon and candidate presentation and communicate to faculty; assist the candidate with travel and accommodations; support new faculty member integration with Group: ID cards, email accounts, etc. Maintain faculty research data bank. Organize and maintain Group's archive files. Provide administrative and operational support for the Academic Center Director, including Organize logistics of the Center guest speaker series and annual international conference. Compile and maintain the Center newsletter current on the center website on an ongoing basis and supervise its production on paper on a quarterly basis. Assist case competition coach with the preparation of materials and all related logistics for annual case competitions. Perform any other duties necessary to maintain effective operations as identified by the Group Coordinator. Systemize and assist in faculty work/projects; receive, prioritize and delegate for the best method of completion and timely turnaround. Alert faculty to peak pressure times and encourage the submission of projects to allow for a timely turnaround. In absence of other support staff, provide direct support to complete projects. Place textbook adoptions and cases each semester for 20 – 30 professors. Create syllabi, exams, papers, presentations, spreadsheets, letters, research-related materials, articles to be published in major journals, chapters from books, tent cards, mail merges, etc. Update faculty teaching schedules/office hours each semester Arrange for proctoring exams/tests/quizzes for faculty. Support faculty with committee responsibilities, special projects, and professional activities; coordinate meetings and events, arrange rooms and equipment Relieve faculty of the burden of many administrative tasks, including ordering audiovisual equipment; ordering desk copies of textbooks; examination copies of cases; class packets for students; sending/receiving fax messages. Responsible for change of grade forms, retrieving articles and other materials from the library. Copying, printing, and scanning documents. Receive and direct telephone messages. Required Qualifications: Minimum of three years related experience with a demonstration of increasing responsibilities. Bachelor's degree preferred. Ability to operate in a multicultural environment required. Must have demonstrated flexibility and ability to adapt to a varying range of needs. Exceptional multi-tasking, organizational, and communication skills. Strong interpersonal, oral, and written communication skills. Must be able to interact with individuals at all levels with diplomacy, discretion, and tact. Must be a self-starter with an ability to work independently, and in a team setting, using sound judgment, and with a demonstrated ability to take responsibility for activities that arise and need to be taken care of. Dependability essential. Excellent proofreading skills with flexibility to adapt to new technology and various computer/software applications. Must be able to maintain a high level of confidentiality. Must have excellent computer and professional skills with proficiency in Microsoft Word, Excel, PowerPoint, Outlook, and database management.     This job posting is brought to you by Contemporaries Inc., one of the best temp agencies in Boston MA. Also available for payrolling employees in Boston and Greater Boston.   Read the full article

[spacetimewithstuartgary]

SpaceX CRS-24 launching multiple life science investigations to the The microgravity environment on the International Space Station (ISS) has a profound impact on cells and tissues, allowing researchers to conduct life sciences research in ways not possible on the ground. SpaceX’s 24th Commercial Resupply Services (CRS) mission to the orbiting laboratory will deliver a variety of life science payloads sponsored by the ISS National Laboratory. From stem cell research on neurodegenerative diseases to a tissue chip experiment studying the blood-brain barrier and an investigation testing the use of bacteria to protect DNA from the stresses of spaceflight—the research launching on this mission is helping to improve the quality of life for people on Earth. Microgravity affects organisms—from bacteria to humans—inducing changes such as altered gene expression and DNA regulation, changes in cellular function and physiology, and 3D aggregation of cells. Research leveraging these effects can drive advances in pharmaceutical development, disease modeling, regenerative medicine, and many other areas within the life sciences. Below are highlights of several life sciences investigations sponsored by the ISS National Laboratory that are launching on SpaceX CRS-24. The National Stem Cell Foundation is collaborating with the Exomedicine Institute on a unique 3D study of neurodegeneration in the absence of gravity using cells from patients with primary progressive multiple sclerosis (PPMS) and Parkinson’s disease (PD). This marks the first time that disease-specific cells from patients with PPMS and PD will be studied on the ISS to observe the cell-to-cell interactions of neurodegeneration and neuroinflammation when the gravitational forces affecting cells on Earth are removed. Results from this investigation, which is supported by ISS National Lab Commercial Service Provider Space Tango, could further enhance knowledge regarding the genetic makeup of these debilitating diseases. Boston-based pharmaceutical company Emulate is launching an investigation using proprietary tissue chip technology to examine the effects of microgravity on the blood-brain barrier. This project, funded by the National Center for Advancing Translational Sciences (part of the National Institutes of Health), builds on an initial tissue chip investigation that Emulate launched in 2019. Tissue chips contain human cells grown on an artificial scaffold to model the structure and function of human tissue. For this study, Emulate will use its Brain-Chip, which consists of living neuronal and vascular endothelial cells in a micro-engineered environment. The blood-brain barrier is a semi-permeable barrier that allows selective passage of certain molecules and gases while preventing the passage of others. It is a critical component involved in maintaining homeostasis, and disruption of the barrier can lead to or cause neurological dysfunction or disease. Results from this investigation, which is also supported by Space Tango, may provide insight into the relationship between inflammation and brain function, leading to a better understanding of neurodegenerative diseases such as Alzheimer’s and Parkinson’s. DNA components are integral to synthetic biology and bioengineering of organisms for a variety of applications, such as producing pharmaceuticals, improving consumer products, and developing clean plastics. An investigation from ISS National Lab Commercial Service Provider Rhodium Scientific, in collaboration with Lawrence Berkeley National Laboratory, will test the use of specific bacterial strains to protect and preserve DNA during the stresses of launch, in-orbit stowage, and return to Earth. Results could help to create more rugged biological components and advance these technologies for use in space and in extreme environments on Earth. These are only a few of the ISS National Lab-sponsored investigations launching on SpaceX CRS-24. This mission, contracted by NASA, is slated to launch no earlier than December 21 at 5:06 a.m. EST from NASA’s Kennedy Space Center.