#fatty liver diseases treatment in Gujarat

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Revolutionizing Liver Transplants: Pioneering Surgeons and Advanced Techniques

Dr. Anand Khakhar is a renowned liver transplant surgeon, recognized for her exceptional expertise and precision in performing complex liver transplant surgeries, ensuring optimal patient outcomes and post-operative care.

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Fatty Liver and Ayurvedic Treatment

When too much fat gathers in the liver, it causes a problem known as fatty liver disorder. It can be cured, but if not treated properly, it might get worse over time. Fatty liver is often linked to excessive drinking of alcohol and similar substances that can intoxicate. Fatty Liver Disease (FLD) happens when liver cells hold too much fat, leading to inflammation and increasing the risk of hepatitis. FLD makes it hard for the liver to naturally remove fat from the body, creating a harmful cycle. Because drinking alcohol is a major cause of FLD, more than all other factors combined, the disease is divided into two types: Alcoholic steatosis and nonalcoholic steatosis. Non-alcoholic fatty liver disease disrupts the liver’s normal functions, while alcoholic fatty liver disease shows specific symptoms like jaundice, fever, spider veins, and a higher-than-usual white blood cell count.

Ayurvedic Perspective on Fatty Liver

According to Ayurveda, the liver is the source of one of the primary energies, called pitta. Pitta, characterized by its hot and light qualities, governs metabolic and biochemical functions that generate energy and heat. On the other hand, Kapha possesses a cold and stabilizing nature. When the Kapha dosha rises excessively, it suppresses the pitta and its role in supporting the liver. Hence, it can be deduced that fatty liver disease results from an elevated Kapha dosha.

Causes of Fatty Liver Disease

While there isn’t definitive evidence explaining why some individuals are more susceptible to fatty liver diseases than others, various studies have established a connection between underlying health conditions and FLDs. Let’s explore some of the primary causes of fatty liver. Are you seeking a natural and effective solution for “Fatty Liver Ayurvedic Treatment in Gujarat”? Look no further! Nimba Nature Cure is your haven for holistic well-being, offering a comprehensive and personalized approach to address fatty liver concerns through time-tested Ayurvedic treatments.

Obesity

Being overweight is a major contributor to FLD and other health issues. Obesity isn’t just about gaining extra pounds; it also indicates an imbalance in your body’s fat-muscle ratio, putting excessive pressure on your bones. Consequently, the inclination to move and engage in physical activity decreases significantly, resulting in various health problems. The risk of FLD is further heightened when there’s an excess accumulation of fat in the abdominal area.

Type 2 Diabetes

As we’re aware, diabetes disrupts the natural insulin levels in your body, and it also seems to encourage the buildup of fat in the liver. This can lead to inflammation or the formation of scar tissue in the liver.

Drinking Too Much Alcohol

People who drink too much alcohol are much more likely to get fatty liver disease than those who don’t. Alcohol affects how the liver normally works, especially its ability to process fat. If the liver can’t break down the extra fat in its cells, it can lead to fatty liver disease and other problems that might show up in the following weeks.

High Triglyceride Levels

Having too many triglycerides circulating in the blood can also lead to fat building up in the liver. This is a big factor in causing non-alcoholic fatty liver disease.

Symptoms of Fatty Liver Disease

Pain in the Abdomen

Abdominal pain can have various causes, but persistent discomfort over several days could be indicative of fatty liver disease. Seeking a diagnosis early is essential for proper management.

Feeling Full

Have you noticed a sudden decrease in your appetite or a feeling of fullness despite eating less? These could be symptoms of fatty liver disease. While reduced physical activity may affect appetite, persistent feelings of nausea and weakness warrant a thorough diagnosis.

Unexplained Weight Loss

If you’re experiencing unintentional weight loss and fatigue, it could be linked to a fatty liver. However, it’s crucial not to make assumptions. Consult a healthcare professional to determine the precise cause behind the weight loss and undergo the necessary tests.

Signs of Jaundice: Pale Skin and Yellowish Eyes

If your skin appears pale and the whites of your eyes have turned yellow, it’s a clear sign of jaundice, a serious symptom associated with certain fatty liver diseases. Prompt treatment is crucial, as jaundice can be life-threatening and should not be taken lightly.

Symptoms of Fatty Liver Disease: Swollen Abdomen and Legs (Edema)

While bloating and edema may both cause a swollen abdomen, if you also experience swelling in your legs, along with fatigue and unexplained weight loss, it’s important to get tested for fatty liver disease.

Managing Fatty Liver: Treatment and Home Remedies

In the early stages, Fatty Liver Disease can be controlled and cured through lifestyle adjustments and dietary changes. Consider incorporating the following home remedies and lifestyle modifications to safeguard your health.

Aloe Vera Gel

Drinking aloe vera gel is a great way to purify your blood. Moreover, aloe vera supports liver function and may assist in managing fatty liver diseases. You can consume aloe vera gel as is, with lukewarm water, or mix it with citrus fruit juice for a more palatable taste.

Take Low-Fat Diet:

As part of the Ayurvedic diet plan for fatty liver, it’s suggested to cut back on your fat intake temporarily. This helps ease the load on your liver, allowing it to naturally handle fat deposits. Trimming fat from your diet can also support your ongoing treatment, leading to positive results sooner than you might expect.

Avoid Sugar

While you might have a different perspective, it’s crucial to recognize that sugar can be more detrimental than fat, as indicated by a surprising scientific finding. Therefore, it is advisable to steer clear of sugar. As an alternative, jaggery and honey can serve as healthier substitutes for sugar. This explains their frequent use in various herbal formulations to enhance the taste.

Increase fiber in your diet:

Introducing more fiber into your diet has a purifying effect on the digestive system and internal organs. Augmenting fiber intake can potentially enhance metabolism and support optimal liver function. Additionally, it plays a role in regulating body weight, acting as a preventive measure against the development of fatty liver diseases.

Avoid Alcohol:

Heavy alcohol consumption is a leading cause of fatty liver diseases. These issues are common in regular drinkers, but even short-term binges can trigger symptoms. It’s crucial to end drinking habits to allow the liver to naturally remove fat cells while it still can.

Apple cider vinegar

Apple cider vinegar (ACV) is a potent fat-cutting agent commonly integrated into weight loss programs. Intriguingly, it aids in metabolizing fat deposits in the liver, alleviating inflammation, and enhancing overall liver function for prompt relief. To incorporate ACV into your routine, consider consuming it with lukewarm water twice a day. To enhance the taste, you can add honey. Simply mix one tablespoon of ACV with one cup of water and have it before meals.

Papaya

Papaya, often underrated in Indian households, holds significant benefits and is esteemed in Ayurveda. Incorporating a daily slice of papaya into your diet can aid in reducing dietary fats and naturally treating fatty liver diseases.

Ayurvedic Medicines and Their Applications

Given the unique body constitution and varied responses to home remedies, Ayurvedic medicines play a crucial role in providing targeted solutions tailored to individual needs. While some may find home remedies effective, Ayurvedic medicines offer a structured approach to addressing diverse physiological and psychological health concerns.

Nimba Nature Cure, among the oldest Ayurveda institutions in Gujarat, offers a diverse range of herbal formulations catering to individuals of all ages and genders. Take the first step towards revitalizing your liver health through our specialized “Fatty Liver Ayurvedic Treatment.” Call us today at +91 834731 3333/+91 81550 12274 or visit our website at https://www.nimba.in/ to schedule your consultation. Rediscover the balance, energy, and vitality that Ayurveda can bring to your life.

This Blog Originally Published Here: https://www.nimba.in/fatty-liver-and-ayurvedic-treatment/

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Gastroenterologist in Ahmedabad : missiongastrohospital.com

MISSION GASTRO HOSPITAL – CHAIRMAN’S MESSAGE

Mission Gastro Hospital wants to create a world-class center in Gastroenterology with professional patient friendly attitude.

Looking forward to provide the best in the field of Gastroenterology, Hepatology and Endoscopy.

Mission Gastro Hospital in Ahmedabad

Dr. Chirag N Shah founded Mission Gastro Hospital (MGH) in 2019. Our vision is to ensure that world class quality care in the field of gastroenterology is accessible to everyone. Located in the heart of Ahmedabad, MGH is a 10 bedded hospital with a special focus on gastroenterology problems. State of the art equipment and facilities in our humble set-up have earned us the recognition of the best gastroenterology hospital in India.

Our in-house team of gastroenterology specialists provides round the clock accurate diagnosis for all gastrointestinal diseases. With doctors having more than a decade of experience in the field, you will find our specialist gastroenterology consultant available to serve you 24/7. Patients can book an appointment with Dr. Chirag at our gastroenterology hospital in Ahmedabad for any stomach, liver or pancreatic problems

Contact Us

For appointment

07948959591 / 07929710071 / 7567859591

For Emergency Call

Dr. Chirag N Shah – 7567159591

Dr. Dhaval Gupta – 9664680034 / 9819277795

Dr. Pratin Bhatt – 9699643889

Address

603, Golden Icon,

Above Hyundai Showroom,

Besides Qaraar Banquets,

Shymal to Shivrajani Road,

132 Feet Ring Rd,

Satellite, Ahmedabad, Gujarat 380015

Gastroenterology Facility and Procedures at Mission Gastro Hospital

We are the leading center with advanced endoscopy, gastroenterology and hepatology facilities. Acclaimed as the best gastro hospital in India, we provide medicinal and surgical endoscopy for diagnosis of a multitude of gastrointestinal diseases:

• GERD                                                    

• Constipation

• Liver Cirrhosis                                    

• Crohn’s Disease

• H. Pylori                                              

• Ulcerative Colitis

• Hepatitis-A, B, C                                  

• Colon Cancer

• Irritable Bowel Syndrome                 

• Colonic Diverticulitis

• Jaundice                                             

• Tuberculosis (Abdominal & Intestinal)

• Pancreatitis                                        

• Obesity

• Liver Abscess                                    

• Fatty Liver

Dr. Chirag, our Head Consultant has ensured that regular and advanced procedures are all available at MGH for rapid diagnosis of patients. It ensures low turnaround time for patients traveling from outside the city as well. Some of the advanced diagnostic procedures followed at our gastroenterology hospital in Ahmedabad include:

Fibroscan

H Pylori Breath Test

Endoscopic Treatment of GERD

Pediatric Endoscopy

Obesity Balloon Placement

HD Endoscopy with Narrow Band Imaging

Esophageal Manometry

Flexible Sigmoidoscopy

Endoscopic Ultrasound (EUS)

24-Hr pH study (with & without impedance

Pediatric Gastroenterologist at Mission Gastro Hospital

While a majority of our patients are adults, Dr. Chirag Shah has successfully handled several complicated gastroenterology problems for children.

Ensuring that patients especially children feel cared for and safe at our hospital is our first priority and that is just one of the qualities that makes us the best gastroenterology hospital in India.

Services :

Gastroenterologist in Ahmedabad

Gastro Hospital

Top 10 gastroenterologist in India

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Endoscopy Test in Ahmedabad

Gastrology endoscopy

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Gastrologist

[brahmhomeo]

What Is Fatty Liver ?

Fatty Liver Best Treatment In Homeopathy

Liver is the largest organ inside body. It helps body to digest food, store energy, and remove poisons. Fatty liver disease is a condition in which fat builds up in liver. 

Symptoms

Loss of appetite

Nausea and vomiting

Abdominal tenderness

Enlarged liver

Pain in the upper right abdomen

Abdominal swelling (ascites)

Yellowing of the skin and eyes (jaundice)

Fever, which is often low-grade

Fatigue and weakness

Weight loss

Causes

Overweight or obesity

High blood sugar 

High cholesterol

High levels of triglycerides in the blood

Eating outside, junk food

Sedentary life style

[drpathikparikh]

How to treat alcohol associated liver disease – Dr. Pathik Parikh

How to treat alcohol associated liver disease

Treatment of alcohol related liver disease encompasses multiple steps. Just asking to stop alcohol is not enough. Here are the things which we need to look at while dealing with alcohol related liver disease

best doctors for liver disease

Abstinence Counselling

Alcohol withdrawal

Alcohol Craving

Alcohol associated fatty liver and hepatitis

Fibrosis and Cirrhosis – Complication of cirrhosis

Liver Transplant

hepatic problem treatment in ahmedabad

General Measures

Alcohol abstinence is the cornerstone of therapy

Early management of Alcohol dependence is recommended in all patients

Considering the potential risk of Wernicke’s encephalopathy supplementation with B-complex vitamins is recommended

Behavioural Treatment

Cognitive behavioural Therapy

Motivational enhancement

Contingency management

Nutritional Therapy

High protein diet – Do not restrict proteins

High calorie diet – Can eat routine home-made foods including roti, sabzi, dal and rice

Can have milk and milk products – add protein powder to it

Low salt diet – Avoid papad, pickles

All fruits and vegetables including coconut water

Multivitamin supplementation

Alcohol Withdrawal

Chlordiazepoxide is preferred if patient do not have advanced liver disease

Lorazepam is preferred in advanced cirrhosis

Diazepam is avoided

Alcohol Craving

Baclofen and acamprosate may be preferred

Disulfiram to be used only under supervision

Gabapentin, Ondansetron, Topiramate has off label use

Alcoholic Hepatitis

Nutrition is the treatment of choice. All patients should get adequate nutrition. Do not restrict any foo

Steroids to be used in patients with severe alcoholic hepatitis

Pentoxyfylline, UDCA, Glutathione, Silymarin, Metadoxine, SAMe – all have non proven benefit

Hepatologist consultation is must as those patients who do not respond may need transplant

Alcohol cirrhosis

These patients are treated as same way as any other cirrhosis

Need screening for varices and hepatocellular carcinoma

Liver Transplant

Liver transplant should be considered in such patients when alcoholic hepatitis fails to respond to medical management

Liver transplant to be considered for cirrhosis of liver and its complications

Psychiatric fitness stating willingness to abstain is of paramount importance

The above is the management in brief about alcohol related liver disease. If you have any patient suffering from alcohol and associated liver problems, do consult your hepatologist. To know more, feel free to call 8652119730

Make An Appointment

Zydus Hospitals Road, Nr. Sola Bridge, S.G. Highway, Ahmedabad, Gujarat 380054

Website: www.drpathikparikh.com

[gastrosurgerysurat]

Liver Cancer: Prevention is in Your Hands

Do you know the liver is the largest internal organ of the body? It weighs around 1.36-1.39 kilograms. Vital for your body’s metabolic functions and immune system, the liver plays a crucial role in your health and well-being.

One of the deadliest diseases that affect the liver is cancer. According to the World Cancer Research Institute (WCRF), liver cancer is the sixth most common cancer in the world. In 2018 alone, 8,40,000 new liver cancer cases were registered across the world. The American Cancer Society estimates that liver cancer accounts for more than 700,000 deaths each year.

The deadly liver cancer affects both genders and with a growing number of cases every year, it is essential to spread awareness and lower the fatality rates.

There are two types of liver cancers:

A. Primary Liver Cancer that begins in the liver cells. It includes hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma, hepatoblastoma, etc.

B. Secondary Liver Cancer, also called metastatic liver cancer, doesn’t initiate in the liver but it spreads to the organ over a period of time. The origin of this type of cancer can be colon, bladder, pancreas, kidneys, ovaries, breast, stomach, etc.

Why is Liver Cancer so Common Today?

Primary liver cancer is highly prevalent in underdeveloped and developing nations. It is estimated that liver cancer is one of the top ten reasons for deaths among Indians. Lack of awareness, unhealthy lifestyle and inaccessibility to affordable treatment are a few of the reasons why liver cancer is affecting so many people today.

The problem with HCC - liver cancer is that it rarely shows any symptoms in the early stages. And, even if there are any symptoms such as nausea, vomiting or abdominal pain, they are often ignored as common digestive issues. In order to prevent the spread of liver cancer, you must know all of its symptoms.

1. Weight loss and loss of appetite.

2. Extreme fatigue and unexplained exhaustion.

3. Nausea or vomiting.

4. Enlarged liver or spleen

5. Discomfort in the upper abdomen.

6. Abdominal pain.

7. Easy bruising and bleeding.

8. Itching.

9. Jaundice.

10. White chalky stools, etc.

Let’s find out the risk factors associated with liver cancer to understand more about the disease:

1. HCC is more common among males than in females.

2. The fibrolamellar subtype of HCC is more prevalent in females.

3. Certain ethnicities and races including Asians, have higher rates of liver cancer.

4. Chronic infection due to Hepatitis B (HBV) or Hepatitis C (HCV).

5. Cirrhosis, hemochromatosis and Wilson's disease, etc.

6. Autoimmune diseases such as primary biliary cirrhosis (PBC) and certain inherited metabolic diseases can cause cirrhosis. It can lead to liver cancer.

7. Excessive fat accumulation in the liver/ non-alcoholic fatty liver disease.

8. Higher blood sugar levels.

9. Exposure to aflatoxins.

10. Excessive alcohol consumption.

11. Smoking and consumption of tobacco in other forms.

12. Long-term use of anabolic steroids.

13. Obesity and Type 2 diabetes.

Prevent Liver Cancer: Tips for Leading a Healthy Life

As the liver has the capacity to regenerate, it is possible to remove a part of the liver that is affected by cancer. But, if the remaining liver is unhealthy, a liver transplant may become crucial.

Even though technology has advanced in recent years and survival rates have increased, those who suffer from liver cancer can also suffer from physical, emotional and financial exhaustion. The only solution? Focus on the preventable risk factors. Work on leading a healthy life and prevent the occurrence of deadly diseases such as liver cancer.

Avoid Hepatitis B and Hepatitis C infections

Avoid sharing needles and adhere to safe sex practices to prevent the spread of the virus. If you are at risk for HBV or HCV, monitor your health and watch out for common symptoms of liver diseases.

Reduce the Consumption of Alcohol and Tobacco

Along with cirrhosis and liver cancer, these vices have the potential to cause several different problems in the body.

Maintain a Healthy Weight

People with obesity are prone to diabetes and fatty liver diseases, both of which have a close link to liver cancer. Maintain an active lifestyle and focus on eating nutritious food.

Avoid Exposure to Aflatoxins

Aflatoxins are a group of toxins that are found in agricultural crops including maize, peanuts, cottonseed, tree nuts, etc. In order to avoid exposure to aflatoxins, avoid consuming contaminated grains.

Do not ignore Routine Checkups

Early detection is the key to saving your life from liver cancer. Visit your surgical gastroenterologist for regular medical checkups for early detection and treatment of liver cancer.

Prevention is in Your Hands!

According to a report published in December 2017, JAMA Oncology found out that incidences of liver cancer have increased by 75% between 1990 and 2015. Even though the rate of increase for liver cancer is very high, there is a ray of light. Specialists have observed that a majority of liver cancer diagnoses are due to preventable risk factors.

It means if we focus on reducing the risk factors of liver cancer, there are higher chances of us leading a healthy life.

Early detection and accurate treatment by a liver surgeon can help you in leading a healthy life. If you are showing symptoms of liver cancer, visit an experienced surgical gastroenterologist today. Book appointment with South Gujarat’s first National Board Certified HPB and GI surgeon.

[juniperpublishers-crdoj]

Antiobesity Activity of Liraglutide on High Fat Diet-Induced Obesity in Wistar Rats

Authored by Vinay Kumar

Abstract

Liraglutide is a glucagon like peptide-1 (GLP-1) analogue. GLP-1 is a potent inhibitor of motility and gastric emptying and has also been shown to inhibit gastric acid secretion. The inhibition of gastric emptying leads to decreased food intake and reduced body weight. The aim of the present study was to investigate the antiobesity effect of the Liraglutide on high fat diet (HFD) induced obesity in Wistar rats. Obesity was induced by oral feeding of HFD for six weeks. The antiobesity effect of Liraglutide (0.2mg/kg, i.p. for 14 days) in HFD fed rats was evaluated by the measurement of body mass index (BMI), body weight gain, food intake, hemodynamic changes (systolic, diastolic, mean blood pressure and heart rate), serum leptin, lipid profiles (triglycerides, total cholesterol, LDL-cholesterol, HDL-cholesterol), glucose. Organ (Liver) and visceral fat pad weights were measured. Liraglutide significantly reduced BMI, body weight gain, and mean blood pressure, serum leptin, lipids and glucose levels while it significantly increased the serum HDL-cholesterol, as compared to the HFD fed rats. The results of the present study suggest that a potential role of Liraglutide as a clinical tool for obesity treatment.

Keywords: Anti-obesity; High fat diet; Liraglutide; Leptin; Insulin.

    Introduction

Obesity has increased at an alarming rate in recent years and is now a worldwide public health problem [1]. It is one of the most common nutritional disorders in humans. Obesity can be defined as syndrome characterized by an increase in body fat stores, mainly due to an imbalance between energy intake and energy expenditure. Obesity results when energy intake exceeds energy expenditure. The global epidemic of obesity is rapidly evolving as one of the major global health issues as it is frequently associated with a number of diseases with high mortality and morbidity such as diabetes, cancer, arthritis, hypertension, stroke, and myocardial infarction [2]. It is generally accepted that the tremendous rise in the obesity prevalence across the globe is driven primarily by a combination of increased calorie intake and decreased physical activity, and strongly influenced by our genetic background [3]. Obesity is associated with substantial increases in morbidity, premature mortality, impaired quality of life and large healthcare costs [4]. The major co-morbidities include type 2 diabetes, metabolic syndrome, hypertension, dyslipidaemia, myocardial infarction, stroke, certain cancers, sleep, apnoea and osteoarthritis [5]. Easy access to high-calorie packaged foods, sedentary lifestyles and a predilection for gizmos have resulted in almost 70% Indians in mega-cities such as Mumbai, Delhi, Bangalore or Chennai being overweight or obese, says a new multi-city survey. Diet and physical activity remain the cornerstones of therapy for obesity, although results have been disappointing. Obese patients who are able to lose weight by eating better and exercising generally regain the lost weight over time. The difficulty in maintaining long-term weight loss through behaviour modification has led to an increasing interest in other avenues of treatment, particularly pharmacotherapy. To date, only two medications-Sibutramine and Orlistat-have been approved for long-term use in the treatment of obesity and additional effective pharmacological treatments are needed [6].

Liraglutide is a glucagon-like peptide-1 receptor analogue, which is obtained by derivatising glucagon-like peptide-1 with a fatty acid. The liraglutide is well tolerated, sustains weight loss over 2 years and improves cardiovascular risk factors [7]. Liraglutide suppress the food intake and body weight in rats [8]. Obesity management is a modern challenge because of the rapid evolution of unfavorable lifestyles and unfortunately there are no safe and effective treatments applicable to the large majority of obese/overweight people [9]. Therefore, the present study was designed to investigate the antiobesity effect of Liraglutide on high fat diet induced obesity in Wistar rats.

    Materials and Methods

Animals

The experimental study was carried out in male Wistar rats weighing 150-200g body weight and the experimental protocol was approved by Institutional Animal Ethics Committee (IAEC) of KIET School of Pharmacy, Ghaziabad (UP) (Registration number: 1099/07/CPCSEA, dated 27.07, 2007) as per the Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA) guidelines. The animals were kept in polypropylene cages (6 in each cage) under standard laboratory conditions (12 hrs. light and 12hrs. dark :: day : night cycle) and had free access to commercial pellet diet (Pranav Agro Industries, New Delhi) and water ad libitum. The animal house temperature was maintained at 25±2 °C and relative humidity was also maintained at 50±15%.

Induction of obesity by feeding high fat diet

Experimental obesity was induced by feeding of high fat diet consisting of the following materials (corn starch, casein, lard, cholesterol, sodium cholate, soybean oil, coconut oil, wheat bran, mineral mix, vitamin mix were added to 1kg of rat chow diet) to rats for period of six weeks.

Experimental design

30 male Wistar rats were included in the present study. Animals were randomly allocated into five groups of six animals each and treated as follows: Normal Control Group: Rats fed with normal rat chow diet for 6 weeks; High Fat Diet Control Group: Rats fed with high fat diet for 6 weeks; Liraglutide Treated Group: Rats fed with high fat diet for 6 weeks+from 29th day Liraglutide (0.2mg/kg, i.p) for 2 weeks; Orlistat Treated Group: Rats fed with high fat diet for 6 weeks+from 29th day Orlistat (10mg/kg, i.p) for 2 weeks; Perse Group: Rats fed with normal chow diet for 6 weeks+from 29th day Liraglutide for 2 weeks.

Measurement of anthropometric parameters

Body mass index (BMI kg/m2), daily food intake (g/d) and daily water intake (ml/d) were measured.

Measurement of hemodynamic parameters

Hemodynamic parameters (systolic, diastolic and mean arterial blood pressure) were measurement by non-invasive blood pressure recorder using rat tail-cuff method (AD Instrument, Australia).

Biochemical estimations in serum

Blood was collected from the retro-orbital plexus of the both groups of overnight fasted rats using microcapillary tubes on 29th day. Serum was separated by centrifugation (4000rpm, 10min) and transferred to Eppendorf tubes. The concentrations high density lipoprotein-cholesterol (Reckon Diagnostics Pvt. Ltd., Baroda, Gujarat, India), glucose, total cholesterol (TC) and triglycerides (TGs) (all the three from Span diagnostics Ltd., Surat, Gujarat, India), in serum were measured with commercial kits. The concentration of leptin in the serum was measured with rat leptin ELISA kit (BioVendor, Brno, Czech Republic).

    Determination of Liver Weight and Visceral Fat Pad Weights

On the final day of experiment the rats were fasted overnight and sacrificed by cervical dislocation and then liver and visceral fat pads (epididymal, perirenal and mesentric) were removed, washed with normal saline and weighed [10].

Statistical analysis

All values were expressed as Mean IS Standard Error of Mean (S.E.M). Statistical analysis was performed using InStat 3Software. Groups of data were compared with the analysis of variance (ANOVA) followed by Dunnett's test. Values were considered statistically significant when p<0.05.

    Results

Effect of liraglutide on BMI, food intake and water intake

All values were expressed as Mean±SEM, (n=6); aP<0.01 as compared to the Normal Control Group; bP<0.05 as compared to the high fat diet Group; cP>0.05 as compared to Normal Control Group.

The mean BMI, food intake and water intake were decreased the BMI, food intake and water intake as compared to significantly (p<0.01) increased in high fat diet fed group as the HFD treated group, while there was no significant changes compared to the normal control group. Liraglutide (0.2mg/kg,(p>0.05) in the BMI in perse group as compared to the normal i.p) and Orlistat (10mg/kg, i.p) treatment significantly (p<0.05)control group (Table 1).

Effect of liraglutide on hemodynamic parameters

All values were expressed as Mean±SEM, (n=6); aP<0.01 as compared Group; cP>0.05 as compared to Normal Control Group.

All hemodynamic parameters (systolic, diastolic, mean arterial BP and heart rate) were significantly increased (p<0.01) in high fat diet treated group as compared to the normal control group. All hemodynamic parameters were significantly decreased (p<0.01) in Liraglutide and Orlistat treated groups as compared to HFD treated group (Table 2).

Effect of liraglutide on serum leptin and glucose levels

All values were expressed as Mean±SEM, (n=6); aP<0.01 as compared to the Normal Control Group; bP<0.05 as compared to the high Fat Diet Group; cP>0.05 as compared to Normal Control Group.

All values were expressed as Mean±SEM, (n=6); aP<0.01 as compared to the Normal Control Group; bP<0.05 as compared to the high Fat Diet Group; cP>0.05 as compared to Normal Control Group.

Figure 1 & 2 shows that Liraglutide treatment serum leptin and glucose levels were significantly (p<0.01) increased in HFD treated rats as compared to the normal control rats. Serum leptin and glucose levels were significantly decreased in Liraglutide and Orlistat treated groups as compared to the HFD fed group.

Effect of liraglutide on serum lipid profile levels

HFD treated group showed significant (p<0.01) increased levels TC, TGs, low density lipoprotein-cholesterol (LDL-C) and very low density lipoprotein-cholesterol (VLDL-C) and while HDL-C levels significantly (p<0.01) decreased as compared to the normal control group. All these levels were significantly reversed in Liraglutide and Orlistat treated groups as compared to the HFD fed group (Table 3).

Effect of liraglutide on liver weight and visceral fat pad weights

Liver weight and visceral fat pad weights (mesenteric, perirenal and epididymal) were significantly increased in HFD fed group as compared to the normal control group. The visceral fat pad weights of perirenal fat, mesenteric and epididymal fat in the HFD + Liraglutide and HFD + orlistat groups were significantly (p<.001) decreased as compared with those of the HFD group (Table 4).

    Discussion

Obesity is a medical condition in which excess body fat has been accumulated mainly due to sedentary life styles, lack of exercise and intake of energy rich high fat diet. The global prevalence of obesity is increasing rapidly among adults as well as among children and is associated with serious mortalities including a high incidence of type 2 diabetes, hyperlipidemia, hypercholesterolemia, fatty liver, cardiovascular diseases, osteroarthritis as well as an increased risk of many forms of cancer [11]. The currently available treatment options are not potent enough to control obesity permanently besides they produce side effects. Hence, there is a great demand for safer and long term effective drugs to treat this global epidemic problem. Hence, in the present work the anti-obesity activity of Liraglutide on high fat diet induced obesity in Wistar was investigated by analyzing the BMI, body weight, organ and fat pad weight and blood biochemical profiles. Dietary fat is calorically dense and extremely palatable. It is easily over consumed because it can cause less satiety than carbohydrate and protein [12]. Therefore, a HFD can lead to hyperphagia, weight gain, and increased adiposity. The feeding of HFD for 4 weeks produced a significant increase in body weight, total fat pad weight, basal/ fasting plasma glucose, insulin, basal triglyceride (TG) and total cholesterol (TC) levels in male rats [13]. In present study, there was significant increase in body mass index (BMI) and body weight gain in rats fed with high fat diet as compared to the normal control rats. BMI is a simple index of weight-for-height that is commonly used to classify underweight, overweight and obesity in adults [14]. This study corroborate with the findings of Altunkaynak [15] who reported that BMI was significantly increased in rats with high fat diet fed for 8 weeks as compared to the control group The increased body weight found in HFD rats might be due to the consumption of a diet rich in energy in the form of saturated fats (lard) and its deposition in various body fat pads and decreased energy expenditure.

Liraglutide (0.2mg/kg, i.p) and Orlistat (10mg/kg, i.p) treatment significantly (p<0.01) decreased the BMI and body weight gain as compared to the HFD treated group. Further, our results showed a significant (p<0.05) decrease in food intake and water intake by administration of Liraglutide (0.2 mg/kg, i.p). After 6 weeks feeding with HFD, hemodynamic parameters were significantly (p<0.01) elevated in HFD fed rats as compared to normal healthy control rats. Activation of the sympathetic nervous system contributes to blood pressure (BP) elevation in high-fat diet-induced obesity [16]. When HFD fed rats were treated with Liraglutide (0.2mg/kg, i.p), there were significant (p<0.01) decrease in hemodynamic changes.

In the present study, serum glucose and leptin levels were increased in the HFD group as compared to the normal control group, while glucose levels were significantly decreased by Orlistat and Liraglutide treatment. Diet-induced obesity dysregulated glucose homeostasis and causes hyperglycemia [17]. This is consistent with previous study that feeding of HFD for a period of 4 weeks produced a significant increase in plasma glucose levels. Fried et al. [18] indicated that basal levels of leptin are known to be strongly positively correlated with body fat on a HFD. A fat-enriched diet is regarded as an important factor in the development of cardiac diseases because it leads to the development of hyperlipidemia, atherosclerosis, and abnormal lipid metabolism [19]. The data of present study clearly showed that feeding of the HFD increased the concentrations of serum TC, LDL- C, VLDL-C, TGs in experimental rats. Lavie & Milani [20] indicated that obesity adversely affects plasma lipids, especially by increasing TC, LDL- C, VLDL-C, TGs and decreasing the level of HDL-cholesterol. The levels of TGs, TC, LDL- C, VLDL-C were significantly (p<0.01) decreased by Liraglutide (0.2mg/kg, i.p) and Orlistat treatment (10mg/kg, i.p) treatment groups. Organ's weight (liver) and visceral fat pad weights (perirenal, mesentric fat and epididymal fat) were significantly increased in rats fed with HFD. HFD produces adiposity i.e. deposition of fat on the adipose tissues. Liver weight and visceral fats were significantly decreased by Liraglutide.

Conclusion

The possible explanation for an anti-obesity effect of Liraglutide via suppression of dyslipidaemia, leptin, insulin, gastric emptying and reduction of appetite in obese rats fed with HFD. The results of the present study provide initial evidence that Liraglutide could be useful intervention for the treatment of obesity.

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What are the side effects of obesity?

It’s easy to gain weight. Heck, there are lots of delicious temptations all around us! What’s different is shedding the unwanted pounds/kgs and keeping them off. Admit it, we all want to eat what we want, but no one want be overweight or obese.

                        Obesity is one of the leading problems in the world. In the past 30 years, childhood obesity has more than doubled in young children and quadrupled in adolescents and adults.

Consequences of Obesity

The consequences of obesity can be split into three groups, physical, psychological and social. You can find out more about these:

Physical Consequences

People who are overweight have an increased risk of:

Coronary heart disease

  High blood pressure 

Strokes 

Type 2 diabetes

Some cancers

Experiencing fertility problems

  Non-alcoholic fatty liver disease

In addition to the above, obesity can reduce your life expectancy by up to 9 years and many chronic diseases can be prevented by maintaining a healthy weight.

Being overweight can also put extra pressure on joints and limbs, making activity quite difficult and sometimes any movement at all can be painful.

Coronary heart disease

High blood pressure 

Strokes 

Type 2 diabetes

Some cancers

Experiencing fertility problems

Non-alcoholic fatty liver disease

In addition to the above, obesity can reduce your life expectancy by up to 9 years and many chronic diseases can be prevented by maintaining a healthy weight.

Being overweight can also put extra pressure on joints and limbs, making activity quite difficult and sometimes any movement at all can be painful.

  Physiological Consequences

Studies have shown that obesity can lead to psychological problems such as:

Depression

Anxiety

Low quality of life

Low self-esteem

Body dissatisfaction

Social Consequences

Studies have shown that obesity can lead to psychological problems such as:

More likely to suffer from prejudice and discrimination in some situations (for example employment, travel, schooling, healthcare, retail etc)

Fewer friends

Lower educational attainment

Lower employment

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We use most effective and safe Medicines to improve impaired hormones, metabolism or diseases generated after gaining weight. We just don’t go for Cosmetic Weight Loss / We Search cause of gaining Weight; try to help to relief in diseases & physical complain developed after gaining weight.   

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[anandkhakar]

Types of Liver Damage

The liver is a vital organ that conducts hundreds of functions including metabolism, energy storage, and detoxification. It aids in the digestion of food, the conversion of food into energy, and the storage of energy until needed. It also aids in the removal of toxins from your bloodstream.

The term "liver disease" refers to any ailment that affects your liver. These different liver diseases can arise for a variety of causes, but they all have the potential to harm your liver and impair its daily function.

Types of liver damage

Let’s look at a few main liver diseases.

Hepatitis

Hepatitis is a liver ailment caused by a viral infection. It causes inflammation and damage to your liver, making it harder for it to operate properly. Hepatitis is contagious in all forms, but you can lower your risk by getting vaccinated against types A and B or taking other preventive measures, such as practicing safe sex and not sharing needles. There are 5 types of Hepatitis

Hepatitis A is usually transmitted through contaminated food or water. Symptoms may go away without therapy, although it may take a few weeks to recover.

Hepatitis B is either acute (short-term) or chronic (long-term). It is transmitted through body fluids like blood and semen. Hepatitis B is treated, but there is no cure. Early treatment is critical for avoiding issues, so it's important to have regular checkups if you’re at risk.

Hepatitis C can be both acute or chronic. Contact with blood from someone who has hepatitis C is a common way for it to spread. While it may not create symptoms in the early stages, it might eventually lead to chronic liver damage.

Hepatitis D is dangerous hepatitis that can only be obtained by persons who already have hepatitis B. It cannot be contracted on its own. It can also be acute or chronic in nature.

Drinking polluted water is the most common cause of hepatitis E. It usually clears up on its own after a few weeks with no long-term consequences.

https://www.livertransplant.org/images/types-of-liver-damage.gif

Fatty liver disease

Fatty liver disease is caused by fat accumulation in the liver.

Fatty liver disease is categorized into two types:

Alcoholic fatty liver disease is caused by excessive alcohol consumption, whereas nonalcoholic fatty liver disease is caused by other factors. Experts are still attempting to understand.

Both types of fatty liver disease can damage the liver, leading to cirrhosis and liver failure if left untreated. Diet and other lifestyle modifications can help to alleviate symptoms and lower the chance of problems.

Autoimmune conditions.

Autoimmune diseases occur when your immune system attacks healthy cells in your body.

Several autoimmune diseases cause your immune system to damage your cells and liver, such as:

Autoimmune Hepatitis. This illness produces inflammation in your liver when your immune system attacks it. It can progress to cirrhosis and liver failure if left untreated.

Primary Biliary cirrhosis. Damage to the bile ducts in your liver causes an accumulation of bile, resulting in this condition. Cirrhosis and liver failure can develop as a result of PBC.

Genetic conditions.

Your liver can also be affected by several hereditary disorders that you inherit from one of your parents:

Hemochromatosis is a condition in which your body stores more iron than it requires. Your organs, including your liver, retain this iron. If not addressed properly, this might cause long-term damage.

Wilson's disease causes the liver to absorb copper rather than releasing it through the bile ducts. Your liver may eventually become too damaged to hold any more copper, allowing it to travel through your bloodstream and harm other organs, including your brain.

Cancer

Liver Cancer begins in the liver. Secondary liver cancer occurs when cancer begins elsewhere in the body and spreads to the liver.

Hepatocellular carcinoma is a type of liver cancer. It usually manifests as a series of tiny tumors in your liver, although it can also begin as a single tumor.

Other liver illnesses, particularly those that go untreated, may contribute to the development of liver cancer.

Cirrhosis

Cirrhosis is the scarring of the liver caused by illnesses and other sources of liver injury, such as alcoholism. Cystic fibrosis and syphilis can both cause liver damage and, in the worst-case scenario, cirrhosis.

Cirrhosis is generally curable in its early stages by addressing the underlying cause. However, if left untreated, it can lead to more difficulties and even death.

Liver failure

Chronic liver failure occurs when a large portion of your liver is damaged and unable to function normally. Liver failure caused by liver disease and cirrhosis usually occurs gradually. It's possible that you won't experience any symptoms at first. However, over time, you may begin to notice: Jaundice, Diarrhea, fatigue or weakness, and nausea.

It's a serious condition that needs to be managed on a regular basis.

Acute liver failure, on the other hand, occurs unexpectedly, frequently as a result of an overdose or poisoning.

ACUTE-LIVER FAILURE

Acute liver failure is defined as the loss of liver function that happens suddenly — within days or weeks — in a person who does not have any prior liver disease. A hepatitis virus or drugs like acetaminophen are the most prevalent causes. Acute liver failure is rarer than chronic liver failure, which takes longer to develop.

Acute liver failure, sometimes called fulminant hepatic failure, can lead to significant complications such as excessive bleeding and increased head pressure. It's a medical emergency that necessitates admission to the hospital.

Acute liver failure can occasionally be treated and reversed, depending on the causes. However, in many cases, a liver transplant may be the only option.

Acute liver failure is a life-threatening condition that can occur abruptly in otherwise healthy people. Seek medical help right away if you or someone you know suffers sudden yellowing of the eyes or skin, soreness in the upper abdomen, or other unexpected changes in mental state, personality, or behavior.

CHRONIC LIVER FAILURE

Acute liver failure develops more slowly than chronic liver failure. You may not experience any symptoms for months or even years. Cirrhosis, which is usually induced by long-term alcohol use, is a common cause of chronic liver failure. When good liver tissue is replaced by scar tissue, cirrhosis develops.

Your liver gets inflamed as a result of chronic liver failure. Over time, this inflammation leads to the creation of scar tissue. Your liver begins to deteriorate as your body replaces healthy tissue with scar tissue.

Cirrhosis or Alcohol-related Liver Disease (ALRD) are the most common causes of chronic liver failure. According to the American Liver Foundation, the most frequent cause of cirrhosis is alcoholism.

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Hope for Little Warriors: Why and How Children May Need a Liver Transplant

Dr..Anand Khakhar, a renowned hepatologist in India, is widely regarded for expertise in liver diseases, offering exceptional care and innovative treatments to patients nationwide.

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Best liver transplant surgeon in Gujarat

Dr.Anand Khakhar: Highly skilled liver transplant surgeon renowned for his expertise and successful outcomes in Gujarat

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NOURISHING YOUR WAY TO RECOVERY: POST-LIVER TRANSPLANT DIET AND NUTRITION

Dr..Anand Khakhar, a renowned hepatologist in India, is widely regarded for expertise in liver diseases, offering exceptional care and innovative treatments to patients nationwide.

[anandkhakar]

Common Liver diseases - liver transplant surgery

Although liver disease is stereotypically linked to alcohol or drugs, the truth is that there are over 100 known forms of liver disease caused by a variety of factors. liver transplant surgery.

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Liver transplant in India , post-liver transplant diet and nutrition

Dr..Anand Khakhar, a renowned hepatologist in India, is widely regarded for expertise in liver diseases, offering exceptional care and innovative treatments to patients nationwide.

[anandkhakar]

Liver transplant in India , post-liver transplant diet and nutrition

Dr..Anand Khakhar, a renowned hepatologist in India, is widely regarded for expertise in liver diseases, offering exceptional care and innovative treatments to patients nationwide.

[anandkhakar]

Best liver transplant surgeon in Gujarat

NAFLD (Non-Alcoholic Fatty Liver Disease) is a silent disease and it is incredibly common nowadays. It affects 28% of the global population, more than 60% of those with type 2 diabetes. Need to know more about it? Visit Dr Anand Khakhar and his team.