#highthroughput

[amiralabtronorg]

Labtron Multi-tube Vortex Mixer can be mixed at 500–2500 rpm with the Labtron Multi-tube Vortex Mixer, which has a brushless DC motor and digital LED display. Ideal for high-throughput processing, it has a timer range of 1 minute to 99 hours and 59 minutes, as well as replaceable foam racks for tubes with a diameter of 10-29 mm.

[learnandgrowcommunity]

Session 26 : 5G SA & 5G-NSA Architecture and Deployment strategy and open RAN

Video Link - https://youtu.be/WJx_klJDuEg

Subscribe to "Learn And Grow Community" Follow #LearnAndGrowCommunity

[techdirectarchive]

(via How to install Redis on Linux System)

[tbrc34]

Liquid Handling System Market 2025-2033: Precision and Efficiency in Labs

Liquid Handling System Market plays a pivotal role in scientific advancements, enabling precise liquid measurement and transfer in laboratories worldwide. These systems are integral to sectors like pharmaceuticals, biotechnology, and academic research, supporting applications such as drug discovery, genomics, and clinical diagnostics.

To Request Sample Report : https://www.globalinsightservices.com/request-sample/?id=GIS20834 &utm_source=SnehaPatil&utm_medium=Article

Among the market segments, automated liquid handling systems dominate with a 45% share, driven by their unmatched precision and efficiency in high-throughput screening. Manual pipettes retain their relevance, accounting for 30% of the market, thanks to their affordability and versatility in smaller laboratories. The semi-automated systems segment holds 25%, bridging the gap between cost and automation needs.

North America leads the market, benefiting from robust R&D investments and a significant presence of pharmaceutical and biotech firms. Europe, with its established healthcare infrastructure, follows closely, with Germany spearheading innovation. The Asia-Pacific region is poised for rapid growth, propelled by expanding healthcare investments and research activities in countries like China and India.

In 2023, the market volume was estimated at 800 million units, projected to reach 1.2 billion units by 2033. Key players such as Thermo Fisher Scientific, Eppendorf AG, and Mettler Toledo are driving market dynamics through innovations like integrated solutions and user-friendly interfaces.

Regulations, including FDA guidelines and ISO standards, shape market strategies, emphasizing compliance and quality assurance. Future growth will be fueled by investments in automation, AI, and machine learning, enhancing accuracy and operational efficiency. Despite challenges like high initial costs and system complexities, the market holds promising opportunities in digitization and customization services.

#LiquidHandling #LaboratoryInnovation #PrecisionScience #DrugDiscovery #AutomationTech #BiotechTools #GenomicsResearch #AIInLabs #ScientificAdvancements #PharmaTech #LabEquipment #HighThroughput #HealthcareInnovation #CustomSolutions #R&DExcellence

[lovelypol]

"Growth and Innovations in Metabolomics Services Market 2024-2033"

From 2024 to 2033, metabolomics services are at the forefront of revolutionizing precision medicine, offering unprecedented insights into metabolic processes and disease pathways. Advanced analytical techniques and high-throughput technologies are enabling comprehensive metabolic profiling, facilitating early disease detection, personalized treatment plans, and targeted therapies. Integration with AI and machine learning is enhancing data interpretation and predictive analytics, driving innovations in biomarker discovery and drug development. Collaboration between academia, industry, and healthcare is accelerating the translation of metabolomics research into clinical applications, heralding a new era of healthcare.

#Metabolomics #PrecisionMedicine #BiomarkerDiscovery #AIInHealthcare #MachineLearning #MetabolicProfiling #EarlyDetection #PersonalizedTherapies #DrugDevelopment #HealthTech #BiomedicalResearch #ClinicalApplications #NextGenHealthcare #DiseasePathways #AdvancedAnalytics #HighThroughput #PredictiveAnalytics #HealthcareInnovation #TranslationalResearch #FutureOfMedicine

[steplead]

Imagine a world where every bottle you hold is a masterpiece of engineering and precision. That's the realm of PET bottle blow molding machines, where science and artistry converge to create the perfect plastic containers for your favorite beverages. #PETBottles #BlowMoldingMachines #PlasticContainers #DrinkingBottles

At the heart of this process lies the mighty blow molding machine, a towering giant that breathes life into preforms, transforming them into sturdy, captivating bottles. With advanced temperature controls and adjustable blowing pressure, these machines deliver consistent, high-quality results that surpass industry standards. #AdvancedTechnology #ConsistentQuality #HighPerformance #IndustryLeader

But what truly sets these machines apart is their ability to cater to a wide range of applications, sizes, and production demands. From the smallest of bottles to the largest of containers, these marvels of engineering can handle it all, ensuring that your product always looks its best. #Versatile #CustomizableDesigns #ScalableProduction #PremiumPackaging

Imagine running your fingers along the smooth, flawless surface of a freshly blown bottle, marveling at its clarity and strength. That's the power of stretch blow molding, a technique that stretches the container in both axial and hoop directions, improving its top load, clarity, drop impact tolerance, barrier abilities, and tensile strength. #StretchBlowMolding #ImprovedBottlePerformance #HighClarityBottles #StrongBottles

But it's not just about the final product; it's about the entire process. These machines are designed with efficiency in mind, capable of producing up to 15,000 bottles per hour with minimal waste and maximum precision. #HighThroughput #EfficientProduction #MinimalWaste #PrecisionEngineering

Investing in a PET bottle blow molding machine from iBottling is more than just a purchase; it's a commitment to excellence, sustainability, and customer satisfaction. With a two-year quality warranty and on-time delivery guaranteed, you can rest assured that your investment is in good hands. #QualityGuarantee #OnTimeDelivery #CustomerSatisfaction #SustainableManufacturing

So, whether you're in the beverage industry, the chemical industry, or any other sector that requires top-notch plastic containers, embrace the future of bottle manufacturing with iBottling's PET bottle blow molding machines. #BeverageIndustry #ChemicalIndustry #PlasticContainers #FutureofBottleManufacturing #PETBottleBlowMoldingMachines #iBottling #TurnkeyBottlingEquipment #BottlingEquipmentManufacturer

#BottleMoldingExpertise #PackagingInnovations #SustainablePackaging #BottlingAutomation

[smsgatewayindia]

Why Choose SMSGatewayCenter.com: Your Gateway to Efficient Communication

Discover the power of #BulkSMSServices tailored to meet your unique business needs. Choose #SMSGatewayCenter for cutting-edge technology, #GlobalReach, customizable solutions, and reliable customer support. Stay compliant with #TRAI regulations and ensure data security. #BusinessGrowth #CustomerEngagement

BulkSMS #GlobalMessaging #CommunicationSolutions #BusinessMessaging #DataSecurity #TRAICompliance #CustomerSupport #Technology #Customization #BusinessSuccess #MessagingPlatform #UserFriendly #RealTimeReports #SenderID #SMSMarketing #CustomerEngagement #MultiLanguageSupport #SecureMessaging #InnovativeTechnology #ReliableService #CustomerTestimonials #A/BTesting #HighThroughput #CampaignManagement #MobileAppIntegration #DataAnalytics #SLA #MessageTemplates #PersonalizedMessaging #MultiChannelCommunication #EfficientMessaging #CustomerRetention

[kofigroup]

We’re representing an accomplished software engineer who previously worked for Google, currently works for a Computer Vision startup, and developed a high-throughput, low-latency serving framework for distributed key-value datasets

[mikyit]

Bosch has reduced the test time for its #Vivalytic machine 🔬 to 39 minutes with five #Covid19 😷 tests simultaneously in a world first This helps tackle the major #drawback of #throughput and cartridge production for #DNA test 💉 machines and is a world first, says the company.

[lupinepublishers]

Lupine Publishers | Somatic Mutations in Cancer-Free Individuals: A Liquid Biopsy Connection

Lupine Publishers| Open Access Journal of Oncology and Medicine 

Abstract

Somatic mutations have been perceived as the causal event in the origin of the vast majority of cancers. Advanced massively parallel, highthroughput DNA sequencing have enabled the comprehensive characterization of somatic mutations in a large number of tumor samples for precision and personalized therapy. Understanding how these observed genetic alterations give rise to specific cancer phenotypes represents an ultimate goal of cancer genomics. However, somatic mutations are also commonly found in healthy individuals, which interfere with the effectiveness for cancer diagnostics.

Keywords: Somatic mutation; Germline; Cell-free DNA; Liquid biopsy; Next-generation sequencing

Abbreviations: NGS: Next-Generation Sequencing ; cfDNA: Cell-free DNA; MAF: Mutant Allele Frequency

Introduction

Mutations in healthy individuals are not all germline

Over the course of our lifetime, there are many millions of cell divisions in the body. By chance alone, mutations will definitely occur. Indeed, spontaneous somatic mutations constantly occur in individual cells. These background mutations arise either from replication errors or from DNA damage that is repaired incorrectly or left unrepaired, and have been detected in healthy tissues, including blood, skin, liver, colon, and small intestine [1-3]. Deepsequencing studies in normal tissues also surprisingly identified cancer-driving mutations, e.g., in blood, driver mutations can be detected in ~10%of individuals older than 65 years of age and resemble patterns seen in leukemia patients. Individuals carrying these driver mutations have an elevated future risk of blood cancers [4-6], suggesting that these are genuine precancerous clones. Further, a detailed analysis of 31,717 cancer cases and 26,136 cancer-free controls from 13 genome-wide association studies revealed that the majority, if not all, of aberrations that were observed in the cancer-associated cohort were also seen in cancer-free subjects, albeit at lower frequency [7,8].

Somatic mutations in healthy individuals are very prevalent, with an average mutation number of around 2–6 mutations/1 M bases [9,10]. The baseline somatic mutation spectrum in healthy population not only can help fill the gaps for the establishing early cancer diagnosis strategies, but also argues against the idea of using normal cells as germline control to make somatic mutation calls in sequencing tests. Moreover, the same driver mutation could exist in both tumor and normal cells yet with distinct biological effects, we should not simply define the threshold of mutation detection by removing the background mutations found in a healthy population. Taken together, we need to incorporate and carefully calibrate the background somatic mutations in healthy individuals; the fact is they are not all germline mutations.

Somatic driver mutations found in healthy population by liquid biopsy

With the dramatically decreased cost of next-generation sequencing (NGS) in recent years, it is now practical to screen a large number of individuals at ultra-deep sequencing depths to identify cancer-related mutations. Cell-free DNA (cfDNA) in the blood circulation of cancer patients (as liquid biopsy) have emerged as key biomarkers for cancer monitoring and treatment decisionmaking [11]. Both academic research groups and industry players are chasing the pan-cancer screening by a simple blood draw. However, the reliable and accurate application of cfDNA detection requires better understanding of background somatic information in healthy individuals.

We performed ultra-deep target sequencing on 50 cancerassociated genes for plasma cfDNA from a cohort of 129 apparently healthy cancer-free subjects. To increase the confidence of the called mutations, we here defined the mutation as the variant allele frequency greater than 1% and the average depth more than 5,000 xs for demonstration. Our data revealed an age-independent mutation spectrum with average 3.12 somatic mutations per subject (Figure 1). The most frequently mutated genes are TP53 (42%), KIT (6%), KDR (5.5%), PIK3CA (5.5%), EGFR (5%) and PTEN (3.7%). These results highlighted the prevalence of some cancer-associated driver mutations in healthy individuals as background mutations. We also demonstrated the concordance between our results and a recent study for revealing the real somatic mutation in healthy population.

Figure 1: Distribution plots of somatic mutation detected in a cohort of 129 healthy subjects.

The study by Xia et al. [12] examined the background somatic mutations in white blood cells and cfDNA in healthy controls based on sequencing data from 821 non-cancer individuals with the aim of understanding the baseline profile of somatic mutations detected in cfDNA. The data comparison was summarized in Figure 2. Although there are differences in study cohort composition, sample volume, extraction methodology and analytical platform, the end results are remarkably similar, i.e., average 3 mutations per subject with an almost identical list of frequently mutated genes. Although varying mutation spectra in cancers have often been attributed to cancerspecific processes, our data suggest that at least a subset of these mutations actually reflect normal tissue-specific processes. This concept is consistent with the idea that a substantial fraction of the mutations found in cancers occur in normal stem cells [13,14].

Figure 2: Comparison of somatic mutation detection in healthy population from two studies.

Normal tissue as a germline control not justified

There is evidence for the presence of tumor-derived cfDNA in early cancers [15]. However, the real fraction of cfDNA that shed by tumor rather than the background somatic mutations is not well illustrated. For clinical application, the low level of tumor mutation as well as the heterogeneity of background mutation present in the circulation needs to be clearly addressed and differentiated to achieve accuracy. Unfortunately, this goal can’t be achieved by pushing detection limit of current advanced technology to below 0.01% mutant allele frequency (MAF). Contrarily, the higher sensitivity will guarantee higher chance to pick up background somatic mutations. Also, the clinical relevance of those lowpercentage tumor mutations is still debatable in terms of treatment decision or regimen change. Each human individual is unique. Every cancer patient is different. No two tumors are the same even resides within the same patient; to distinguish the definitive cancer-specific mutations from background signals observable in plasma is extremely daunting. Evaluation of specificity in plasma cfDNA profiles from large numbers of healthy individuals as representative controls for the cancer population seems farfetched with uncertainty, especially when standardized protocol and optimized technology are still lacking.

Unlike tissue genomic DNA, circulating cfDNA is so diluted and dynamic with a relatively short half-life, making single-point measurement not suitable for clinical application. We reason that cfDNA in circulation is truly under a continuous selection pressure to select for highly aggressive/proliferative clones, as disease progressing the low-abundant tumor clones will either evolve and dominate or vanish by the immune clean-up processes, therefore longitudinal clinical follow-up should be performed to identify the best time and target for precision therapy, meanwhile to filter out contaminating background mutations. To achieve high clinical specificity, a cfDNA-based test must be capable of distinguishing between the background signals originating from non-cancer or pre-cancerous processes and the invasive malignancy of clinical interest. It is still possible that mutational signatures in cfDNA could distinguish basic biological processes from malignant and pathological processes.

Figure 3: A representative mutational trending curve after filtering out background mutations.

Here we propose a combined approach based on the tumor evolutional principle of “survival and domination of the fittest” in circulation that is to perform multiple time-point monitoring, filter out potential background mutations (e.g., <1% MAF), reduce sample input volume and interrogate multiple databases. A representative mutational trending curve following our approaches was shown (Figure 3). Our findings underscore the importance of an assessment of the landscape of somatic mutations in cancerfree population, and associated mutation signatures. Somatic mutations and mosaicism in healthy individuals have implications not only for early detection, diagnosis and treatment of cancer using liquid biopsy but also emerging technologies in healthcare. We recommend caution while extending the mutation conclusions to cancer patients by employing matched normal tissue as germline control. To increase sample input and push liquid biopsy sensitivity toward <1% may not serve the interest of detecting low-frequency mutant allele, but only to increase the chance of background mutation contamination. Application of artificial intelligence, machine-learning on big database to create an algorithm for highrisk population screening of cancer is a good idea for preventive medicine, yet the outcome is uncertain given the uniqueness of every patient, each tumor - one size can’t fit all.

For More Lupine Publishers Open Access Journals Please visit our Website:

https://lupinepublishers.us/

For More Articles  Open Access Journal of Oncology and Medicine Please Click Here: https://lupinepublishers.com/cancer-journal/index.php

To Know More About Open Access Publishers Please Click on Lupine Publishers

Follow on LinkedIn: https://www.linkedin.com/company/lupinepublishers

Follow on Twitter:  https://twitter.com/lupine_online

[slimlastforskolins]

Scientists create a machine-learning algorithm that automates high-throughput screens of epigenetic medicines -- ScienceDaily

Scientists create a machine-learning algorithm that automates high-throughput screens of epigenetic medicines — ScienceDaily

Machine learning’s powerful ability to detect patterns in complex data is revolutionizing how we drive, how we diagnose disease and now, how we discover new drugs. Scientists at Sanford Burnham Prebys Medical Discovery Institute have developed a machine-learning algorithm that gleans information from microscope images — allowing for high-throughput epigenetic drug screens that could unlock new…

[learnandgrowcommunity]

Session 25: Open RAN | New Front Haul eCPRI, Mid Haul and Back Haul Connectivity and new requirement

Video Link - https://youtu.be/YIhO7la4O80

In this session, we delve into the crucial components of Open RAN: new front haul eCPRI, mid haul, and back haul connectivity. Understanding these elements is essential for optimizing network performance. We'll cover why new front haul eCPRI is needed, explain the roles of mid haul and back haul, and discuss the advancements required in Open RAN to meet the super-fast latency and throughput demands of modern networks. Join us to learn how these connectivity solutions enhance Open RAN deployments.

Subscribe to "Learn And Grow Community" Follow #LearnAndGrowCommunity

[joshbois]

View this post on Instagram

A post shared by Josh Bois (@joshbois)

So my #quarterly #businesstrips to #washdc pack in some #fun too... #gokarting in between #govdeals and building out some exciting #jointventures // when you balance out that #hardwork with some serious #funmoments it is more #sustainable for #longterm #highthroughput #productivity #execution and maintaining #sanity as a #highbandwidth #executive . . . #washingtondc #northvirginia #northva #reston #nova #dmvarea #contracting #govcontractor (Reston, Virginia) https://www.instagram.com/p/BuGEktBBlzA/?utm_source=ig_tumblr_share&igshid=1ba645m8wtwnv

[survivingscience-blog]

High throughput Westerns in progress. I'm using this to blot for 60 antibodies in 26 samples. Imagine how long that would take to run normally?! • • • #phdlife #phdchat #phd #biophd #biology #molecularbiology #proteins #science #scichat #highthroughput #research #RPPA

[myflixhall]

Cinepelis Nomadland Pelicula Completa ONLINE 2020 HD 1080p

Descargar Nomadland (2020) Drama, Western. Nomadland se puede ver de forma gratuita registrándose. Descargar Nomadland HD Calidad.

Nomadland (2020)

Fecha de estreno : 2020-12-26 Géneros : Drama, Western Runtime : 107 Minutes Home Page : https://www.searchlightpictures.com/nomadland IMDb Page : https://www.imdb.com/title/tt9770150 Company : Cor Cordium Productions, Hear/Say Productions, Highwayman Films Reparto : Frances McDormand, David Strathairn, Linda May, Swankie, Gay DeForest, Patricia Grier, Angela Reyes, Carl R. Hughes, Douglas G. Soul, Ryan Aquino Tagline: Overview : Una mujer de unos sesenta años se embarca en un viaje por el oeste de los Estados Unidos después de perderlo todo en la Gran Recesión, viviendo como una nómada moderna que vive en una furgoneta.

Descargar Nomadland (2020) Pelicula Completa en Espanol. Nomadland se puede ver de forma gratuita registrándose. Descargar Nomadland HD Calidad.

美黛拉 最活跃的医美社区美白瘦脸 ~ 美黛拉医美专栏罗列了网友的医美亲身体验心得通过医美帖子展示最真实医美效果，让你对医美有直观的了解。

MDLI Medical Information System ~ MDL is a leading provider of integrated logistics and decision support systems that enable a highthroughput environment for research and development in the life sciences and chemical industries

MDL Case Information Southern District of Indiana ~ MDL No 2570 IN RE Cook Medical Inc IVC Filters Marketing Sales Practices and Products Liability Litigation Pursuant to 28 § 1407 the Judicial Panel on Multidistrict Litigation JPML has transferred a number of actions to the Southern District of Indiana assigned to Judge Richard L Young and Magistrate Judge Tim A Baker for coordinated or consolidated pretrial proceedings

MDL Porta Troqueles Componentes Resortes y Accesorios ~ MDL México Fabricante de porta troqueles accesorios componentes resortes de troquel y punzones fundada en 1971 MDL ha crecido a lo largo de los años debido a la calidad de sus productos y el compromiso y seriedad que tenemos en atender a nuestros clientes

MDL Components ~ MDL is a wholesale distributor of ball bearing and plain bearing guiding components such as guidepins bushings mechanical springs and hundreds of guiding components interchangeable with Danlystyle guiding components used by thousands of die set manufacturers independent tool and die components distributors and stampers throughout the

Máscara De Látex ~ Máscara De Látex es una marca de ropa orgullosamente mexicana que combina licencias oficiales y tendencias con diseños únicos

Sign in MyDramaList ~ Dont have an account Sign up for MyDramaList Its free and only takes about 30 seconds While you dont have to Sign up in order to view the information on Asian Dramas and Movies making an account has a lot of benefits

Home Map and Data Library ~ MDL Map Collection Our collections consist of over 250000 maps and hundreds of thousands of aerial photographs MDL Spaces MDL has open study space group study rooms and a computer lab Start your search Start your research

MDL Wikipedia ~ MDL 胃透視（独Magendurchleuchtung）の略。 最小記述長 minimum description length。モデル選択基準。 軍事境界線 Military Demarcation Line。 南 北朝鮮の境界線。 モルドバ・レウ Moldovan leu leu moldovenesc。 モルドバの通貨。 1550のローマ数字。 マンダレー国際空港 のIATA 空港コード。

CDM CDMHome ~ The CDM Under the Clean Development Mechanism emissionreduction projects in developing countries can earn certified emission reduction credits These saleable credits can be used by industrialized countries to meet a part of their emission reduction targets under the Kyoto Protocol

Nomadland 2020 Pelicula Completa Online, Descargar Nomadland 2020 Pelicula Completa Torrent, Ver HD Nomadland 2020, Descargar Nomadland Pelicula Completa en Espanol Latino, Nomadland Pelicula Completa en Linea Subtitulado, Nomadland Pelicula Completa Espanol, Watch Nomadland (2020) Online Free, Download Nomadland (2020) Soundtrack, Watch Nomadland (2020) Online Dailymotion, Download Nomadland (2020) Subtitle, Watch Nomadland (2020) Online Best Quality, Watch Nomadland (2020) Free Good Quality, Watch Nomadland (2020) Online Free Yesmovies, Watch Nomadland (2020) Reddit 123movies, Watch Nomadland (2020) Blu Ray Online Free, Download Nomadland (2020) Leaked Full Movie, Download Nomadland (2020) English Version, Watch Nomadland (2020) Good Quality, Watch Nomadland (2020) Download Free, Watch Nomadland (2020)

[smsgatewayindia]

SMPP SOFTWARE

Empower your Business with our Feature-Rich SMPP Software for efficient SMS communication

• High-throughput Message Sending

• Message Queue Management

• Message Routing and Filtering

• Real-time Monitoring and Reporting

• Customizable

https://smppcenter.com

#SMPPsoftware #SMScommunication #highthroughput #messagequeue #messagerouting #realtime #monitoring #reporting #customizable #businessautomation #efficiencyboost