#hypervirulent superbug

[civilmentor1]

CURRENT AFFAIRS - 10 AUGUST 2024

1.DNA PROFILING?? Definition: DNA profiling, also known as DNA fingerprinting, is aforensic technique used to identify individuals based on their uniqueDNA characteristics. It involves comparing DNA samples to assess thelikelihood of a match.● Principles: DNA profiling relies on the fact that no two individuals(except identical twins) have the same DNA sequence, making it apowerful tool for…

[good-health-life]

Wow, the spread of this hypervirulent superbug is truly concerning! The World Health Organization's warning on this is so crucial. We need to take this seriously and act fast to prevent its further escalation. #superbug #healthalert #WHO #hypervirulent

[deblala]

Here we go again! WHO warns of "hypervirulent" superbug posing threat to humanity. - Vigilant Links

https://vigilantlinks.com/2024/08/here-we-go-again-who-warns-of-hypervirulent-superbug-posing-threat-to-humanity/

[nawapon17]

Dangerous strains of 'hypervirulent' superbug detected in US and 15 other countries | Live Science

[news2024news]

A 'Hypervirulent' Superbug Is Spreading and Scaring Health Experts http://dlvr.it/TBQFf6

[kristinsimmons]

Dangers of 'Superbug' Germs Greater Than Believed

There's been an uptick in the number of laboratory studies showing how just one mutation could create highly infectious or "hypervirulent" strains of disease-causing bacteria, fungi and water molds.

Dangers of 'Superbug' Germs Greater Than Believed published first on https://wittooth.tumblr.com/

[mhealthyliving]

Dangers of 'Superbug' Germs Greater Than Believed

Dangers of ‘Superbug’ Germs Greater Than Believed

MONDAY, Dec. 9, 2019 — The risk of new superbugs that pose a threat to human health and food crops is much higher than previously thought, new genetic research shows.

There’s been an uptick in the number of laboratory studies showing how just one mutation could create highly infectious or “hypervirulent” strains of disease-causing bacteria, fungi and water molds.

These include microbes that…

[raymondmccullers]

Vaccine against deadly superbug Klebsiella effective in mice

Researchers have developed a vaccine that is effective, in mice, against hypervirulent strains of Klebsiella that can cause life-threatening infections in healthy adults. Vaccine against deadly superbug Klebsiella effective in mice syndicated from https://triviaqaweb.blogspot.com/

[newstfionline]

Triple Threat: New Pneumonia Is Drug-Resistant, Deadly And Contagious

Michaeleen Doucleff, NPR, September 2, 2017

In the past few years, there have been so many “superbugs” appearing in hospitals around the world, that we haven’t had the time or resources to report on all of them.

But a new type of pneumonia emerging in China seems so important that we dropped what we were doing to write about it.

Doctors in Hangzhou have detected a type of pneumonia that is both highly drug resistant and very deadly. It also spreads easily between people.

The bacterium--a type of Klebsiella pneumoniae--killed five people in an ICU in Hangzhou in 2016, researchers reported Tuesday in the journal Lancet Infectious Diseases.

“This fatal outbreak happened in a brand new hospital with very good hygiene,” says microbiologist Sheng Chen, who co-led the study at the Hong Kong Polytechnic University. “Drug-resistant strains shouldn’t have appeared so quickly.”

The microbe can fight off all drugs available in China, Chen says. “We don’t have anything in China to stop it,” he says. “There is a drug available in the U.S. that should be effective against it, but we haven’t tested it yet.”

In the outbreak, the five patients who died were above age 53. They were all on ventilators after undergoing major surgeries. And they all died from severe lung failure, multiorgan failure or septic shock, the researchers found.

When Chen and his team sequenced the microbes found in the infections, they were shocked at what they saw. These bacteria aren’t like other multidrug-resistant pneumonia reported before. They are a fusion of two dangerous forms.

In the past three decades, two types of K. pneumoniae have appeared in hospitals. The first is a drug-resistant form, called CRE, which can fight off even the toughest antibiotics. Last January, this type of pneumonia killed a woman in Nevada. That strain resisted 26 antibiotics.

The second type of K. pneumoniae causes a very severe form of the disease and is known as “hypervirulent.”

“The disease progresses very fast,” Chen says. “It starts in the lungs and then infects other organs, like the liver.”

This hypervirulent form--which is widespread across Chinese hospitals--causes more damage to the body than other strains. It can spread through communities. And it can even sicken young, healthy adults, Chen says.

For years, doctors feared the two types would one day combine. And now that it has happened, scientists around the world need to be on alert for these triple threat strains, researchers at Rutgers University write in a commentary about the new study.

[fadighanemmd]

Health24.com | Why the dangers of 'superbug' germs are greater than previously believed

Health24.com | Why the dangers of ‘superbug’ germs are greater than previously believed

New genetic research indicates that ‘hypervirulent interactions’ need close monitoring if we are to halt the emergence and spread of severe disease outbreaks.

from Health24 News https://ift.tt/2RDKkVn via IFTTT

[brynawelhouse]

Health24.com | Why the dangers of 'superbug' germs are greater than previously believed

New genetic research indicates that 'hypervirulent interactions' need close monitoring if we are to halt the emergence and spread of severe disease outbreaks. from Health24 News https://www.health24.com/Medical/infectious-diseases/News/why-the-dangers-of-superbug-germs-are-greater-than-previously-believed-20200129-2

[scitechman]

Vaccine Against Deadly Superbug Klebsiella Effective in Mice

Vaccine Against Deadly Superbug Klebsiella Effective in Mice

Scientists have produced and tested, in mice, a vaccine that protects against a worrisome superbug: a hypervirulent form of the bacteria Klebsiella pneumoniae. And they’ve done so by genetically manipulating a harmless form of E. coli, report researchers at Washington University School of Medicine in St. Louis and VaxNewMo, a St. Louis-based startup.

Klebsiella pneumoniae causes a variety of…

[good-health-life]

Amazing how public health advocates are advocating for the Olympics to reconsider their sponsorship deal with Coca-Cola

The recent incident where Cristiano Ronaldo opted for water instead of Coke at a press conference is sending a powerful message. 🌿💧 #PublicHealth #Olympics #CocaCola #HealthierChoices

https://readr.me/rcfg9k Market volatility can spark concerns about the U.Seconomy's endurance. The recent sharp drop in the stock market has caused many to question the economy's stability. What factors led to this decline? #MarketVolatility #USEconomy #StockMarketCrash

https://readr.me/vdj37q Such sad news about David Lynch's health strugglesWishing him a speedy recovery and sending positive thoughts his way. 🙏 #DavidLynch #HealthIssues #GetWellSoon

https://readr.me/dnr57t Wow, the spread of this hypervirulent superbug is truly concerning! Thanks for raising awareness about this important issue. #HealthAlert #Superbug #WHOConcern

https://readr.me/7yzqtv

Such a tragic story

The loss of Lola James, only two years old, due to the heinous actions of her mother's boyfriend Kyle Bevan is heart-wrenching. The fact that there were "missed opportunities" to prevent this devastating outcome is truly unforgivable. #JusticeForLola #ChildSafety #EndDomesticViolence

https://readr.me/mwznsp RFK Jr.'s idea of sending people on antidepressants to 'Wellness Farms' for 'Reparenting' is quite interesting. It's crucial to explore novel approaches to mental health support. #RFKJr #MentalHealth #WellnessFarms

https://readr.me/jfpmvs Eating the right foods is crucial for maintaining good vision health as you age. Check out this list of the 12 best foods that should be part of your diet! #VisionHealth #EyeCare #HealthyEating

https://readr.me/9x7kbd

[kathleenseiber]

Vaccine shows promise against Klebsiella superbug

Scientists have produced and tested, in mice, a vaccine that protects against a worrisome superbug: a hypervirulent form of the bacteria Klebsiella pneumoniae.

Klebsiella pneumoniae causes a variety of infections including rare but life-threatening liver, respiratory tract, bloodstream, and other infections. Little is known about how exactly people become infected, and the bacteria are unusually adept at acquiring resistance to antibiotics. The prototype vaccine, the details of which appear in Proceedings of the National Academy of Sciences, may offer a way to protect people against a lethal infection that is hard to prevent and treat.

“For a long time, Klebsiella was primarily an issue in the hospital setting, so even though drug resistance was a real problem in treating these infections, the impact on the public was limited,” says coauthor David A. Rosen, an assistant professor of pediatrics and of molecular microbiology at Washington University in St. Louis. “But now we’re seeing Klebsiella strains that are virulent enough to cause death or severe disease in healthy people in the community. And in the past five years, the really resistant bugs and the really virulent bugs have begun to merge so we’re beginning to see drug-resistant, hypervirulent strains. And that’s very scary.”

Superbugs spread globally

Hypervirulent strains of Klebsiella caused tens of thousands of infections in China, Taiwan, and South Korea last year, and the bacteria are spreading around the world. About half of people infected with hypervirulent, drug-resistant Klebsiella die. Two types in particular—known as K1 and K2—are responsible for 70% of the cases.

The goal is to get a vaccine ready for human use before the hypervirulent strains start causing disease in even larger numbers of people.

The researchers decided to create a vaccine against the two most common strains of hypervirulent Klebsiella. The bacterium’s outer surface is coated with sugars so the researchers designed a glycoconjugate vaccine composed of these sugars linked to a protein that helps make the vaccine more effective. Similar vaccines have proven highly successful at protecting people against deadly diseases such as bacterial meningitis and typhoid fever.

“Glycoconjugate vaccines are among the most effective, but traditionally they’ve involved a lot of chemical synthesis, which is slow and expensive,” says Christian Harding, a cofounder of VaxNewMo, a St. Louis startup. “We’ve replaced chemistry with biology by engineering E. coli to do all the synthesis for us.”

The researchers genetically modified a harmless strain of E.coli, converting it into tiny biological factories capable of churning out the protein and sugars needed for the vaccine. Then they used another bacterial enzyme to link the proteins and sugars together.

To test the vaccine, the researchers gave groups of 20 mice three doses of the vaccine or a placebo at two-week intervals. Then they challenged the mice with about 50 bacteria of either the K1 or the K2 type. Previous studies had shown that just 50 hypervirulent Klebsiella bacteria are enough to kill a mouse. In contrast, it takes tens of millions of classical Klebsiella—the kind that affects hospitalized people—to be similarly lethal.

Fighting antibiotic resistance

Of the mice that received the placebo, 80% infected with the K1 type and 30% infected with the K2 type died. In contrast, of the vaccinated mice, 80% infected with K1 and all of those infected with K2 survived.

“We are very happy with how effective this vaccine was,” says first author Mario Feldman, associate professor of molecular microbiology. “We’re working on scaling up production and optimizing the protocol so we can be ready to take the vaccine into clinical trials soon.”

The goal is to get a vaccine ready for human use before the hypervirulent strains start causing disease in even larger numbers of people.

“As a pediatrician, I want to see people get immunity to this bug as early as possible,” Rosen says. “It’s still rare in the United States, but given the high likelihood of dying or having severe debilitating disease, I think you could argue for vaccinating everybody. And soon we may not have a choice. The number of cases is increasing, and we’re going to get to the point that we’ll need to vaccinate everybody.”

Support for the work came from the National Institute of Allergy and Infectious Diseases; the National Institutes of Health; the Children’s Discovery Institute of Washington University; and St. Louis Children’s Hospital.

Mario F. Feldman and Christian M. Harding have a financial stake in VaxNewMo LLC, a for-profit entity developing bioconjugate vaccines against Streptococcus pneumoniae and Klebsiella pneumoniae using patented technology derived from the data presented in this and other published manuscripts.

Source: Washington University in St. Louis

The post Vaccine shows promise against Klebsiella superbug appeared first on Futurity.

Vaccine shows promise against Klebsiella superbug published first on https://triviaqaweb.weebly.com/

[kristinsimmons]

Dangers of 'Superbug' Germs Greater Than Believed

There's been an uptick in the number of laboratory studies showing how just one mutation could create highly infectious or "hypervirulent" strains of disease-causing bacteria, fungi and water molds.

Dangers of 'Superbug' Germs Greater Than Believed published first on https://wittooth.tumblr.com/

[scienceblogtumbler]

Vaccine against deadly superbug Klebsiella effective in mice

Vaccine against deadly superbug Klebsiella effective in mice

Scientists have produced and tested, in mice, a vaccine that protects against a worrisome superbug: a hypervirulent form of the bacteria Klebsiella pneumoniae. And they’ve done so by genetically manipulating a harmless form of E. coli, report researchers at Washington University School of Medicine in St. Louis and VaxNewMo, a St. Louis-based startup.

Klebsiella pneumoniae causes a variety of…