#iPhone App Development San Diego

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[synergytop]

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[bitcot]

iPhone app development company in San Diego, California.

Have an idea for an iphone app? Have you always wanted to build your own iphone app that best suits your business needs? You're in luck! We will help you develop an awesome, high-quality iphone app on time. We have the best iphone app development company in San Diego, California. BitCot is one of the best iphone app development companies in San Diego, USA. Our mission is to help you with all your ios app creation needs through the entire development process and support you with customizing your app for maximum usability, scalability, performance and ultimately profitability. We will help you build your iphone app from scratch using our proven methods and development team. Our team of expert developers and designers are dedicated to deliver the best possible IOS app to fit your business needs. bitCot is one of the best iphone app development companies in san diego

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[thewebdevelopmentcompany]

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[lupinepublishers-ado]

Lupine Publishers| Integration of Novel Emerging Technologies for the Management of Type-2 Diabetes

Lupine Publishers | Journal of Diabetes and Obesity

Introduction

The incidence of twin epidemics, obesity and type-2 diabetes are increasing rapidly worldwide in the past two decades [1-7]. By azand large, clinicians manage diabetes by meticulous management of blood glucose levels to meet the guidelines established by professional societies and regulatory agencies (8, 9). The American College of Physicians (ACP) published the most recent guideline in April of this year (8). Major guidance statements include:

a) Clinicians should personalize goals for glycemic control in patients with type-2 diabetes on the basis of a discussion of benefits and harms of pharmacotherapy, patients’ preferences, patients’ general health and life expectancy, treatment burden, and costs of care.

b) Clinicians should aim to achieve an HBA1c level between 7% and 8% in most patients with type-2 diabetes.

c) Clinicians should consider de-intensifying pharmacologic therapy in patients with type-2 diabetes who achieve HBA1c levels less than 6.5%.

d) Clinicians should treat patients with type-2 diabetes to minimize symptoms related to hyperglycemia and avoid targeting an HBA1c level in patients with a life expectancy less than 10 years due to advance age (80 years or older), residence in a nursing home, or chronic conditions (such as dementia, cancer, heart failure) because the harms outweigh the benefits in this population [8]. Recently three major professional bodies have issued guidelines on this topic. They are, American Association of Clinical Endocrinologists, American College of Endocrinology, and the American Diabetes Association [9]. In this overview (point of view), we will briefly discus some of the recent emerging technologies that may help empower and encourage patients to monitor their glucose levels and better manage their post-meal glycemic load.

According to Rebecca Voelker’s report in the recent issue of JAMA Network (May 2018), the.com Food and Drug Administration (FDA) has approved a continuous glucose monitor (CGM) that can work in tandem with mobile medical apps and automated insulin pumps to help people with diabetes manage their interstitial sugar more easily. The Dexcom G6 is the first CGM approved as both a stand-alone device and one that can be integrated into automated insulin dosing systems. According to the manufacturer, Dexcom Inc. of San Diego, California, its newly approved CGM has an easyto- use auto applicator that inserts a small sensor just beneath the skin. The sensor measures glucose levels and a transmitter inside of it sends readings wirelessly every 5 minutes to a receiver or a compatible smartphone or smartwatch. With a mobile app, users can share readings with up to 5 people. No finger sticks are needed for calibration or diabetes treatment decisions. In 2 trials, 324 adults and children aged 2 years or older with diabetes used the Dexcom G6 for 10 days. During multiple clinic visits, their readings were compared with laboratory test results that measured their blood glucose levels. An FDA statement indicated that no adverse events were reported during the studies. We would be glad to validate these sensors if the manufacturers provide them for our clinical evaluation in India.

We in India are validating another CGM (Ambulatory Glucose Monitor, AGM) that is developed by Abbott Diabetes Care, Free Style Libre Pro (www.freestylelibre.com). The sensor comes with an easyto- use auto applicator. Manufacturers claim that the sensor is 48% less bulky than the Dexcom G5 transmitter and sensor. One has to use the reader that is provided by Abbott Diabetes Care. Abbott as well as iPhone do not have any apps to monitor the data from these sensors. However, android phones (with Near Frequency Communication capabilities) can read the data from these sensors. According to my collaborator Dr. Santosh, parents of type-1 diabetes patients love this system as they can keep an eye on the sugar levels of their children. To be competitive, iPhones and Abbott also should develop smart phone Apps. Abbott sensor measures glucose levels every 15 minutes for two weeks. Risk level is assessed for five time periods (there are 2 periods between bedtime and breakfast). A typical graph of median glucose is shown below. Abbott claims a strong correlation between median glucose and HBA1c (Figure 1).

Figure 1:  Abbott Diabetes Care

We are validating the usefulness or otherwise of this new glucose sensor in two independent sites in India (All India Institute of Medical Sciences, Patna, and Karnataka Institute of Endocrinology and Research, Bengaluru). The author has done some preliminary study using this sensor and a typical summary of the results are shown below. Since this study was done by an authorized endocrinologist of Karnataka Institute of Endocrinology and Research (KIER) using me as the test subject, I will refer the subject as the patient. He is (a resident of USA) over 80 years of age with well characterized type-2 diabetes for over 20 years. He is under medications (Metform in 500mg two tablets, twice daily, DPP-4 inhibitor Januvia 50mg/twice daily, Glipizide 10Mg/twice daily) and the graph shown below shows the results of a wellmanaged glucose profile. Author thanks Dr. Santosh Olety(KIER) and MS. Smitha Raja (Noesys software, Bengaluru) for these studies and analysis of the data.

Figure 2 shows a composite data for the duration of the study (12 days). According to this data estimated HBA1c was 7.2 fairly close to the estimated clinical values. Figure 3 gives the mean glucose values for each day (variation in the mean values are not very significant). Currently, we are conducting studies to determine the correlation between the blood glucose measured by the finger prick method and the interstitial glucose measured by these emerging technologies. We also are evaluating the usefulness or otherwise of this method of glucose monitoring for the management of postmeal glucose as well as for screening of indigenous anti-diabetic drugs and their combinations.

Figure 2:  Abbott Diabetes Care

Figure 3:  Abbott Diabetes Care

As the manufacturers of glucose sensors (Dexcom and Abbott) claim, the new glucose sensors that can work in tandem with mobile medical apps and automated insulin pumps help people with diabetes manage their interstitial sugar more easily. As discussed in this overview, these sensors will serve as useful tools to manage post-meal glucose levels as well as for screening anti-diabetic drugs, dietary supplements and herbal products. Emerging technologies in device development, availability of mobile apps, improved analytics will play a very important role in the development of better affordable healthcare.

Acknowledgementment

Author thanks the following collaborators: Dr. M. A Shekar, The Director, Karnataka Institute of Endocrinology and Research (KIER), Dr. Santosh Olety, Pediatric Endocrinologist, KIER, Ms. Smitha (Raja) Bopanna, Co-Founder, Director, Noesys Software, Pvt, Ltd, Bengaluru. Dr. Sadhana Sharma, Professor, Head, Department of Biochemistry, All India Institute of Medical Sciences, Patna. Abbott Diabetes Care, Regional Representatives: Dr. Navneeth Selvan (Southern Region), Dr. Silpi Bardhan (Eastern Region).

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[disgeitihil-blog]

Apple hack app Idle Supermarket Tycoon - Shop

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  Ipad Apple 1.41 Rating 102757 Vote purchase General Manager 304963 Kilobytes publish date 2019-02-07 Make important management decisions to build your empire and transform your small supermarket into one of the greatest in the world!. Features:. - Casual and easy gameplay

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[followtrendings]

Genetic reprogramming increased the life of mice. Soon we will live longer as well

There has been a breakthrough in the bioengineering field. A biotech company raised its hand claiming it did something that hasn’t been done before. It has reprogrammed the genes of mice to make them live longer.  This suggesting us that even one day we could turn back time and be younger to live long. Let's read in detail to find out which company accomplished this and how exactly they did it. 

Which company did this?

You all must be thinking it might be a huge company but it isn’t. In fact, it is a small company named Rejuvenate Bio. It is a San Diego-based biotech company. It made the claim of life extension in mice through a preprint paper on the website BioRxiv.

Source: Google This genetic reprogramming thing is not new. Millions are invested in the hope to reset the cells to a younger and healthy state. And to some extent it is successful. Scientists have already made it to work on single cells in labs but in the whole body of a living organism, it was never successful. But now looking at the paper provided by Rejuvenate Bio, proves that cells can be reprogrammed according to the need to live a longer life. Also Read: FT Tech News 02: Google’s own version of Airtag tracker | Sony new technology to block piracy apps on TVs | Samsung plans for One UI 5.1 rollout | Customizable lock screen feature for Android | Android to have wireless charging | Bill Gates prefers Android over iPhone

How did Rejuvenate Bio reprogram the mice to live longer?

According to Noah Davidsohn, chief scientific officer of Rejuvenate, a method called gene therapy was used in which 3 strong reprogramming genes were inserted in the bodies of the mice. 

You must be thinking what type of mice, healthy or weak? The body condition of the mice can be considered equivalent to a 77-year-old human body. When observed, the normal mice lived 9 weeks and the treated/experimented mice lived 18 weeks on average. This is the time duration measured from the date of treatment for both types of mice. Overall, the life span of the mice was increased by 7%. This means if normal mice live 100 days then treated mice will live 107 days.  Even though the number seems to be small but it is the proof that gene reprogramming is possible in animals. Davidson said this is a very advanced and powerful technology, and here is the proof. I wanted to demonstrate that we can truly accomplish it with our older population. Also Read: FT Tech News 01: Intel’s most powerful processor | Twitter Data Leak Reply and Office Rent | Google Chrome Vulnerability | Microsoft’s Investment In ChatGPT | Google’s Software Developer Kit (SDK) | Microsoft’s VALL-E Project

How it all started?

Shinya Yamanaka, a Japanese researcher, was awarded the Nobel Prize back in 2012 for his discovery of the reprogramming formula. Four years later in 2016, researchers at the Salk Institute made the decision to test the approach on live mice that had a condition that caused them to age prematurely and was comparable to the progeria illness that affects humans. They subjected whole mice to the variables for brief intervals and discovered that some survived longer. The next step was to demonstrate that it could also lengthen the lives of healthy mice. This was a crucial step in order to qualify genetic reprogramming as a legitimate anti-aging strategy for the coming generation. Martin Borch Jensen, the founder of Impetus Grants, an organization that funds aging research said everyone in the research world knows the killer experiment is to treat normal mice and see whether there's increased life span or improvement in general health. Days passed and years passed as well, but no report concluded what was hoped. The dreams of the scientists of breeding very long-lived mice started to fade away. Alejandro Ocampo, a scientist from the University of Lausanne in Switzerland who conducted the initial tests at Salk said that different groups have done this experiment, and the findings have not been favorable so far. However, a team working with mice that were genetically modified right from birth to create Yamanaka's unique factors in their bodies published their initial findings last year. Though the study was regarded as preliminary, the National Institute of Health and Medical Research team discovered a tendency toward higher life spans. Also Read: President of Brazil signs crypto bill into law- What is in the Bitcoin and Crypto Bill? Everything Explained In case of Rejuvenate study, they used gene therapy and viruses that were intentionally modified and designed to transfer genes into the cells of the mice. Normally mice can live a few months in the wild whereas in lab conditions these numbers change to a few years. In the latest experiment conducted, the mice were given the drug when they were 124 weeks old-close to their completion of life span. According to Davidsohn, the treated mice not only lived substantially longer but also performed better on tests of their overall health. According to a US government program that evaluates medicines for their ability to make people live longer, rapamycin and other chemicals can increase mice lifespans by 5% to 15%. To this, Davidson said that the drugs the mice must take for the majority of their lives have no immediate impact, but reprogramming does. This is like you could do nothing throughout your entire life and yet get the profit.

What is people's take on this?

Though scientists praised the trial as a groundbreaking achievement, who are not part of the firm emphasized that whole-body rejuvenation via gene therapy is still an ill-defined notion with significant hazards.  Vittorio Sebastiano, a professor at Stanford University, argues that while it is a lovely intellectual exercise, he would be hesitant to perform something even somewhat comparable to a human. One danger from the potent programming process is the possibility of cancer. Mice often exhibit this effect. Researchers believe other organizations will need to replicate the experiment they have done before they are persuaded, and much more study will be required to understand precisely what changes the reprogramming genes induced in the mice.  Borch Jensen adds, "I'd like to see a different organization do something similar and dig further into what is truly happening. Sebastiano claims that the life-extension effect observed by Rejuvenate may be caused by alterations in a specific organ or set of cells. Not by the whole mouse rejuvenation effect. Rejuvenate's study had a number of flaws, one of which being that it did not thoroughly track which and how many cells were affected by the genetic therapy. Also Read: California county proposed seceding from the United States to form a new state

What's the future ahead?

For now, Rejuvenate is actively creating gene-therapy medications for  both people and pets including one drug to treat heart failure as well. Davidson believes that someday in the future humans will also be able to increase their life expectancy. And that is the reason he is with the project. Many other companies are coming forward with the same sort of ideas but with a certain goal. Meaning they are focusing on either specific illnesses or particular organs of the human body. For instance, Sebastiano cofounded the business named Turn Bio, which seeks to infuse reprogramming elements into people's skin to stop wrinkles or promote hair growth. Life Biosciences is another biotech company that is getting ready to do tests to see if reprogramming eye cells may cure blindness. Read the full article

[onlinewebdevelopment]

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AIS Technolabs San Diego app development company is ranked as the best when it comes to developing Apps. We administer services related to IOS, Android, Cross-platforms, and many more. We have healthy origins in both design and development. We have also partnered with mega-brands to deliver you the best and quality services. Feel free to get in touch with us, and we will take your approach to the next level. Our app development company chooses the right team of specialists for you, whether it’s related to iPhone app development or Android app development, the crew of our app developers works alongside with project managers, graphic designers and solution architects holding you in the loop as well.  

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[synergytop]

Looking for iphone apps development service in San Diego, Los Angeles. At SynergyTop they are specialised ios developers providing top notch services in the industry. Contact: 619-349-4911, +91 8827514783 to get a quote.

[wamatechnology]

Why are mobile applications necessary?

Today, the simplest and best solution is to use mobile marketing to investigate or expand any firm. It helps the business attract more customers and generate online sales. An application designed specifically for a smartphone device, such as a phone, tablet, or TV, is known as a mobile app. Numerous categories of mobile applications exist, including those pertaining to business, finance, news, social networking, banking, gaming, and other subjects. Modern businesses can benefit from using a mobile app since it makes it simple to connect and interact with customers. Smartphone Application development company can be done in a variety of ways.

The timetable may be chosen based on a number of factors, like as the app's complexity, design, and demand. Thanks to technological advancements, anyone may now start creating apps using open-source software.

There are several opportunities for earning money in the mobile app development industry. Advertising is a typical tactic used in applications to make significant cash from the development of Android and iOS mobile apps.

Mobile apps are built by a team of programmers who work in timed iterations to build a component of the overall requirements, then assess and demonstrate their work. A mobile app for Apple's iOS platform typically takes 6 to 8 weeks to develop.

There are many more advantages to mobile app development than just boosting brand recognition. Having a mobile app can help you accomplish your most important business objectives.

Long after it is initially released, an application's creation process is still in progress. Wama Technology has developed Android applications for companies in the banking, medical, building, trade, electronics, logistics, geotechnical engineering, and entertainment sectors. Each of our mobile applications is developed using the same technique.

With the intention of having a major business impact, their dedicated developers have been assigned responsibility for all of their technological projects, from consulting to solution integration, deployment, and market launch.

A mobile app development companies in san Diego, Wama Technology, has a team of full-stack iPhone app developers and strategists who are skilled at creating the most recent mobile applications that are compatible with iOS 13. They also provide comprehensive iOS app development services.

Our app development team has a wealth of industry knowledge in addition to in-depth technological know-how, which allows them to create business-focused iPhone apps that assist organizations in staying one step ahead of the competition. We create, develop, and distribute iPhone apps that consistently provide value over the course of the iPhone application development lifecycle as part of our iPhone app development services.

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