#ibrutinib cost

[thelotusbiotech]

Beyond Leukaemia: Understanding Blood Cancers and Available Treatment Frontiers

Introduction

While the term "blood cancer" often conjures the image of leukaemia, it encompasses a diverse and complex landscape of malignancies affecting the blood, bone marrow, and lymphatic system. This article delves beyond leukaemia, shedding light on various types of blood cancers and exploring the evolving landscape of treatment options.

Understanding Blood Cancers:

Blood cancers arise from uncontrolled growth and abnormal function of blood cells. These cells can be broadly categorized into:

Myeloid cells: These are responsible for immunity and forming various blood cell types. Abnormal growth in these cells leads to myelomas and myeloproliferative neoplasms.

Lymphoid cells: Play a crucial role in the immune system. Uncontrolled growth leads to lymphomas, such as Hodgkin's and non-Hodgkin's.

Plasma cells: Produce antibodies to fight infections—their abnormal growth results in plasma cell dyscrasias, including multiple myeloma.

Beyond Leukaemia: Unveiling the Diversity:

Leukaemia, lymphoma, myeloma, myelodysplastic syndromes (MDS), and myeloproliferative neoplasms (MPN) are among the different kinds of blood cancer. Each has a unique forecasting, course of therapy, and symptoms. It's common to categorise blood cancers as acute or chronic, wherein the former refers to rapid growth. In contrast, the latter refers to slower growth.

Leukaemia, though frequently mentioned, represents only a subset of blood cancers. Other types, each with unique characteristics and complexities, deserve our attention:

Characterised by the uncontrolled growth of lymphocytes, lymphomas can affect various lymph nodes and organs. Treatment approaches vary depending on the lymphoma type and stage.

Myeloma: Arising from plasma cells, multiple myeloma often affects bones and can cause kidney damage. Targeted therapies and bone marrow transplants play a crucial role in its management.

Myeloproliferative neoplasms (MPNs): A group of conditions characterised by the overproduction of blood cells, MPNs can include chronic myeloid leukaemia (CML), essential thrombocythemia, and polycythemia vera. Treatment focuses on controlling cell production and managing symptoms.

What are some common Signs and Symptoms of Blood Cancer?

Persistent fatigue: Feeling constantly tired, even after adequate rest

Unexplained weight loss: Losing weight unintentionally, especially when combined with fatigue.

Fever or night sweats: Fevers that don't resolve or excessive sweating at night can indicate an underlying infection or immune system issues.

Easy bruising or bleeding: Frequent or unusual bruising, bleeding gums, or nosebleeds.

Swollen lymph nodes: Lumps in your neck, armpits, or groin can be a sign your immune system is working overtime, potentially due to blood cancer.

Bone pain: Persistent or unexplained pain in your bones, joints, or back could be caused by bone marrow issues linked to blood cancers.

Changes in appetite: Loss of appetite or feeling full quickly, even after small meals, can be related to various cancers, including blood cancers.

Skin changes: Persistent rashes, itching, or red spots on your skin can sometimes be associated with blood cancers.

Frequent infections: Getting sick more often than usual, with infections that take longer to heal, could indicate weakened immunity linked to blood cancers.

Paleness, or pallor, is the appearance of white skin beneath your lower eyelid as opposed to pink.

Remember that it is crucial to seek professional medical advice for any suspected health concerns. Doctors can provide accurate diagnoses and personalised treatment plans based on individual needs.

Diagnostic Advancements: Navigating the Treatment Landscape

The advancements in diagnosing and treating blood cancers are remarkable. Traditional approaches like chemotherapy, radiation therapy, and bone marrow transplants remain cornerstones, but newer frontiers are emerging:

  These drugs pinpoint specific genetic mutations or proteins driving cancer growth, offering more precise and potentially less toxic treatment options.

Harnessing the body's immune system to recognize and attack cancer cells is revolutionising treatment, particularly for lymphomas and some leukemias.

CAR-T cell therapy, a form of immunotherapy where a patient's T cells are engineered to target cancer cells, has shown promising results for certain blood cancers.

This approach aims to correct genetic mutations responsible for cancer development, holding immense potential for future advancements.

Ibrunat 140mg Capsule: A Targeted Weapon Against B-Cell Blood Cancers

Ibrunat 140mg, also known as Ibrutinib capsules, has emerged as a hope for patients battling B-cell malignancies like chronic lymphocytic leukaemia (CLL) and mantle cell lymphoma. Unlike traditional chemotherapies, this targeted therapy zeroes in on a specific protein crucial for cancer cell survival – Bruton's tyrosine kinase (BTK).

Action Mechanism:

If BTK is a fuel regulator for cancer cells, Ibrunat 140mg acts like a wrench, effectively disrupting this regulator. By halting BTK's activity, the Ibrunat capsule throws a wrench into the cancer cell's machinery, hindering its growth and division and ultimately leading to its programmed cell death.

Advantages:

Ibrunat 140mg has established itself as a first-line treatment for this aggressive lymphoma, often leading to significant remission rates.

Ibrunat 140mg offers a powerful alternative, demonstrating improved outcomes compared to standard therapies.

Research is ongoing for using Ibrunat 140mg in other B-cell malignancies like Waldenstrom's macroglobulinemia and small lymphocytic lymphoma

Under proper medical guidance and supervision and with a valid prescription, one can buy ibrutinib online from various pharmaceutical distributors and traders such as The Lotus Biotech. Finding the right treatment path for B-cell cancers can be overwhelming. Exploring options like generic Ibrutinib, seeking financial assistance programs, and discussing alternatives with your doctor are crucial steps.

While Ibrunat 140mg isn't a cure-all, it represents a significant advancement in targeted cancer therapy. With continued research and increased accessibility, this "molecular wrench" holds immense promise for patients fighting B-cell blood cancers.

Looking Ahead: A Brighter Future?

The journey against blood cancers continues. While significant progress has been made, challenges remain. Some cancers develop resistance to existing therapies, highlighting the need for personalised medicine and continuous research. Additionally, ensuring equitable access to these advancements, particularly in resource-limited settings, is crucial.

Despite the challenges, the future of blood cancer treatment holds immense promise. Ongoing research in targeted therapies, immunotherapy, and gene therapy offers hope for more effective and personalised treatments. Early detection and diagnosis, combined with increased awareness and public health initiatives, can improve outcomes.

By delving beyond leukaemia and acknowledging the diverse spectrum of blood cancers, we can navigate the ever-evolving treatment landscape with greater understanding and hope. The dedication of researchers, healthcare professionals, and patients paves the way for a future where blood cancers are manageable and potentially curable.

[rxmedicoss]

Nitib (IBRUTINIB) | Generic Equivalant to IMBRUVICA

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$187.50

Essential Ingredient – IBRUTINIB

Product Name – Nitib

Manufacturer – HETERO Healtcare Ltd

Packing – Bank of 30 Tabs

Strenth in mg – 140mg.

IBRUTINIB is used to treat many types of CANCER including – MANTEL CELL, LYMPHOMA, CHRONIC LYMPHOCYTIC, LEUKEMIA, SMALL LYMPHOCYTIC LYMPHOMA. IBRUTINIB belongs to a class of medications called KINASE INHIVITORS. IBRUTINIB works by slowing down or stoping the multiplication of CANCER CELL and hence stopping the spread of cancer cell.

[feodorgir78-blog]

Imbruvica (ibrutinib) cost in India and Where to buy

This medication is used to treat certain cancers (such as mantle cell or marginal zone lymphoma, chronic lymphocytic leukemia/small lymphocytic lymphoma, Waldenstrom's macroglobulinemia). Ibrutinib belongs to a class of drugs known as kinase inhibitors. It works by slowing or stopping the growth of cancer cells.

Ibrutinib 140 mg is also used to treat a certain problem that may occur after a stem cell transplant (chronic graft versus host disease). It works by weakening your body's defense system (immune system).

Read the Patient Information Leaflet if available from your pharmacist before you start taking ibrutinib and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with a full glass of water (8 ounces or 240 milliliters) as directed by your doctor, usually once daily. Swallow the capsules and tablets whole. Do not open, break, or chew the capsules. Do not cut, crush, or chew the tablets. Drink plenty of fluids while taking ibrutinib unless otherwise directed by your doctor.

The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). The cost of Imbruvica oral capsule 70 mg is around $13,546 for a supply of 28 capsules,

Do not increase your dose or take this medication more often than prescribed. Your condition will not improve any faster, and your risk of serious side effects will increase.

Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor or pharmacist says you may do so safely. Also avoid eating Seville oranges (often found in marmalade). Grapefruit and Seville oranges can increase the chance of side effects with this medicine. Ask your doctor or pharmacist for more details.

Since this drug can be absorbed through the skin and lungs and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the capsules

Upset stomach, diarrhea, nausea, vomiting, decreased appetite, headache, joint/muscle pain, swelling of ankles/legs/feet, numbness/tingling of arms/legs, anxiety, constipation, dizziness, or tiredness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

This medication may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high. Your doctor may control your blood pressure with medication.

Tell your doctor right away if you have any serious side effects, including: easy bruising/bleeding, dark/tarry/bloody stools, fast/irregular/pounding heartbeat, signs of low red blood cell count (such as rapid breathing, pale skin, shortness of breath). You can easily to buy Ibrunat 140 mg price in india

[galaxysuper23]

What is Ibrutinib cll UAE?

Ibrutinib cost is a relatively new drug used to treat chronic lymphocytic leukemia (CLL). Learn more about Ibrutinib, and how it works and what it could mean to use.

[lisanovitce-blog]

ibrutinib cost

ibrutinib cost

Ibrutix(IMBRUVICA)is a kinase inhibitor indicated for the treatment of adult patients with: 1. Mantle cell lymphoma (MCL) ,Chronic lymphocytic leukemia,Waldenström’s macroglobulinemia (WM),Marginal zone lymphoma (MZL) and Chronic graft versus host disease (cGVHD) after failure of one or more lines of systemic therapy. Ibrutix’s brand name is IMBRUVICA®by Janssen. Ibrutix is a generic oncologic prescription medicine from Beacon, which is one of the biggest pharmaceutical company in Bangladesh.

[pharmaphorumuk]

NHS and Kite sign access deal for Kite’s cancer cell therapy Tecartus

NHS patients in England will be among the first in the world to receive Gilead’s Tecartus cancer cell therapy for certain types of lymphoma, after the company’s specialist Kite unit struck a deal with NICE. 

Marketed as Tecartus (autologous anti-CD19-transduced CD3+) in Europe, the drug was approved in the EU in December for adults with relapsed or refractory mantle cell lymphoma after two or more lines of systemic therapy including a Bruton’s tyrosine kinase (BTK) inhibitor.

It has been approved in the US since July last year and like other CAR-Ts the one-time therapy is expensive at $373,000 a shot in the US.

NICE said in guidance that the treatment can be considered for those with relapsed or refractory mantle cell lymphoma, after treatment with drugs such as AbbVie/Janssen’s Imbruvica (ibrutinib).

Kite has signed a managed access agreement with NHS England that allows for funding via the Cancer Drugs Fund (CDF) at a commercially confidential discount, so more data can be collected for NICE’s cost-effectiveness calculations.

While in most cases reimbursement from the CDF results in regular NHS funding in the long run, manufacturers must usually produce convincing overall survival data before NICE gives this the go-ahead.

But as Bristol-Myers Squibb found out earlier this month with its Opdivo immunotherapy in head and neck cancer, NICE is prepared to say “no” in the absence of the required data after a period of funding on the CDF.

NICE said in a statement that it is looking for further data on progression-free survival, overall survival and age when treatment with Tecartus starts.

This will help reduce uncertainty in evidence while NHS is used on NHS patients.

The NHS has ten providers around the country which will be able to offer this treatment option.

Many parts of the country continue to experience pressures on critical care services, that are required for the administration of a CAR-T therapy and patients can travel to centres further afield to receive their treatment if necessary, NICE said.

There is no standard treatment for adults, who are usually in their 70s, with relapsed or refractory mantle cell lymphoma after a BTK inhibitor. A combination of rituximab, bendamustine and cytarabine (R BAC) is the most common treatment option.

Around 100 patients each year could be treated with this CAR-T therapy.

NHS England has been leading the way with funding of CAR-T (Chimeric Antigen Receptor T-cell) therapies after it became an early adopter of Novartis’ Kymriah the first approved drug from this class in September 2018 in acute lymphoblastic leukaemia (ALL).

CAR-T therapies are made by harvesting a patient’s T-cells, genetically engineering them to target cancer cells and reintroducing them into the body.

The post NHS and Kite sign access deal for Kite’s cancer cell therapy Tecartus appeared first on .

from https://pharmaphorum.com/news/nhs-kite-cancer-therapy/

[rxmedicoss]

IBRUNAT (IBRUTINIB) | Generic Equivalant to IMBRUVICA

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$187.50

Essential Ingredient – IBRUTINIB

Product Name – IBRUNAT

Manufacturer – NATCO PHARMA

Packing – Bank of 30 Tabs

Strenth in mg – 140mg.

IBRUTINIB is used to treat many types of CANCER including – MANTEL CELL, LYMPHOMA, CHRONIC LYMPHOCYTIC, LEUKEMIA, SMALL LYMPHOCYTIC LYMPHOMA. IBRUTINIB belongs to a class of medications called KINASE INHIVITORS. IBRUTINIB works by slowing down or stoping the multiplication of CANCER CELL and hence stopping the spread of cancer cell.

[walterlaake]

Doctors tried to lower $148K cancer drug cost; makers triple price of pill

(credit: Wellness GM)

A drug that treats a variety of white blood cell cancers typically costs about $148,000 a year, and doctors can customize and quickly adjust doses by adjusting how many small-dose pills of it patients should take each day—generally up to four pills. At least, that was the case until now.

Last year, doctors presented results from a small pilot trial hinting that smaller doses could work just as well as the larger dose—dropping patients down from three pills a day to just one. Taking just one pill a day could dramatically reduce costs to around $50,000 a year. And it could lessen unpleasant side-effects, such as diarrhea, muscle and bone pain, and tiredness. But just as doctors were gearing up for more trials on the lower dosages, the makers of the drug revealed plans that torpedoed the doctors’ efforts: they were tripling the price of the drug and changing pill dosages.

The drug, ibrutinib (brand name Imbruvica), typically came in 140mg capsules, of which patients took doses from 140mg per day to 560mg per day depending on their cancer and individual medical situation. (There were also 70mg capsules for patients taking certain treatment combinations or having liver complications.) The pills treat a variety of cancers involving a type of white blood cell called B cells. The cancers include mantle cell lymphoma, which was approved for treatment with four 140mg pills per day, and chronic lymphocytic leukemia, approved to be treated with three 140mg pills per day. Each 140mg pill costs somewhere around $133—for now.

Read 7 remaining paragraphs | Comments

Doctors tried to lower $148K cancer drug cost; makers triple price of pill published first on https://thelaptopguru.tumblr.com/

[digicrunchpage]

Doctors tried to lower $148K cancer drug cost; makers triple price of pill

(credit: Wellness GM)

A drug that treats a variety of white blood cell cancers typically costs about $148,000 a year, and doctors can customize and quickly adjust doses by adjusting how many small-dose pills of it patients should take each day—generally up to four pills. At least, that was the case until now.

Last year, doctors presented results from a small pilot trial hinting that smaller doses could work just as well as the larger dose—dropping patients down from three pills a day to just one. Taking just one pill a day could dramatically reduce costs to around $50,000 a year. And it could lessen unpleasant side-effects, such as diarrhea, muscle and bone pain, and tiredness. But just as doctors were gearing up for more trials on the lower dosages, the makers of the drug revealed plans that torpedoed the doctors’ efforts: they were tripling the price of the drug and changing pill dosages.

The drug, ibrutinib (brand name Imbruvica), typically came in 140mg capsules, of which patients took doses from 140mg per day to 560mg per day depending on their cancer and individual medical situation. (There were also 70mg capsules for patients taking certain treatment combinations or having liver complications.) The pills treat a variety of cancers involving a type of white blood cell called B cells. The cancers include mantle cell lymphoma, which was approved for treatment with four 140mg pills per day, and chronic lymphocytic leukemia, approved to be treated with three 140mg pills per day. Each 140mg pill costs somewhere around $133—for now.

Read 7 remaining paragraphs | Comments

Doctors tried to lower $148K cancer drug cost; makers triple price of pill published first on https://medium.com/@HDDMagReview

[techbotic]

Doctors tried to lower $148K cancer drug cost; makers triple price of pill

(credit: Wellness GM)

A drug that treats a variety of white blood cell cancers typically costs about $148,000 a year, and doctors can customize and quickly adjust doses by adjusting how many small-dose pills of it patients should take each day—generally up to four pills. At least, that was the case until now.

Last year, doctors presented results from a small pilot trial hinting that smaller doses could work just as well as the larger dose—dropping patients down from three pills a day to just one. Taking just one pill a day could dramatically reduce costs to around $50,000 a year. And it could lessen unpleasant side-effects, such as diarrhea, muscle and bone pain, and tiredness. But just as doctors were gearing up for more trials on the lower dosages, the makers of the drug revealed plans that torpedoed the doctors’ efforts: they were tripling the price of the drug and changing pill dosages.

The drug, ibrutinib (brand name Imbruvica), typically came in 140mg capsules, of which patients took doses from 140mg per day to 560mg per day depending on their cancer and individual medical situation. (There were also 70mg capsules for patients taking certain treatment combinations or having liver complications.) The pills treat a variety of cancers involving a type of white blood cell called B cells. The cancers include mantle cell lymphoma, which was approved for treatment with four 140mg pills per day, and chronic lymphocytic leukemia, approved to be treated with three 140mg pills per day. Each 140mg pill costs somewhere around $133—for now.

Read 7 remaining paragraphs | Comments

Doctors tried to lower $148K cancer drug cost; makers triple price of pill published first on https://medium.com/@CPUCHamp

[lucadezzani]

Cost of Cancer Drugs: R&D Spending vs Revenues

Cancer Drugs: R&D Spending vs Revenues

Cost of drugs has been matter of debate in recent years. It is often said that R&D costs to develop new medications are extremely high and this is one of the common arguments used to justify increasing drug prices. According to the estimate by the Tufts Center for the Study of Drug Development, it takes $2.7 billion for a company to bring a single drug to the U.S. market, which is much higher…

[pharmaphorumuk]

Scotland backs Merck/Pfizer’s Bavencio combo for kidney cancer

The Scottish Medicines Consortium (SMC) backed NHS use of nine new medicines at its meeting this week, including Merck KGaA and Pfizer’s Bavencio as a first-line treatment for advanced kidney cancer.

The decision means that PD-1 inhibitor Bavencio (avelumab) can be given to previously-untreated adults diagnosed with advanced renal cell carcinoma – the most common form of kidney cancer – as a combination regimen with Pfizer’s targeted cancer drug Inlyta (axitinib).

Kidney cancer is the seventh most common cancer in Scotland, with approximately 1,200 new cases diagnosed every year.

Pfizer said that Bavencio/Inlyta had previously been available to patients in the UK as part of the Early Access to Medicines Scheme (EAMS), and is the first immunotherapy combination therapy for RCC to be cleared for use in both Scotland and England.

NICE cleared first-line use of the dual regimen in first-line RCC patients in July, but opted to make it available with interim funding via the Cancer Drugs Fund (CDF), which kicks in when upcoming trial evidence is expected to confirm whether the drug will be cost-effective.

The SMC decision came after a PACE (Patient and Clinician Engagement) meeting which heard that RCC is a devastating and incurable disease that is generally diagnosed at an advanced stage with a five-year survival rate of approximately 12%.

It is based on the results of the JAVELIN Renal 101 study, which showed that Bavencio/Inlyta extended progression-free survival for an average of five months compared with Pfizer’s older targeted drug Sutent (sunitinib).

Bavencio/Inlyta isn’t however the first immunotherapy-based regimen to be recommended by the SMC for first-line RCC use.

Last month the panel gave a green light in that setting to Merck & Co/MSD’s PD-1 inhibitor Keytruda (pembrolizumab) plus Inlyta, and last year also backed Bristol-Myers Squibb’s PD-1 drug Opdivo (nivolumab) with CTLA4 inhibitor Yervoy (ipilimumab).

The SMC also backed the following drugs for NHS Scotland use:

Bristol Myers Squibb’s Revlimid (lenalidomide) as monotherapy for the maintenance treatment of adult patients with newly diagnosed multiple myeloma who have undergone autologous stem cell transplantation (ASCT). And in combination with rituximab for adults with previously treated follicular lymphoma;

BioMarin’s Brineura (cerliponase alfa) for neuronal ceroid lipofuscinosis type 2 (CLN2), a life limiting, inherited condition in children that leads to progressive brain damage;

Janssen’s Imbruvica (ibrutinib) for the treatment of rare blood cancer Waldenstrom’s macroglobulinemia (WM) in combination with rituximab;

Amgen’s Kyprolis (carfilzomib) for blood cancer multiple myeloma in patients who have received at least one prior therapy;

Novartis’ Mayzent (siponimod) as a treatment for people with active secondary progressive multiple sclerosis (SPMS);

Menarini Pharma’s Vaborem (meropenem/vaborbactam), an antibiotic for the treatment of a number of multidrug-resistant serious infections; and

Dr Falk Pharma’s orodispersible Jorveza (budesonide) for eosinophilic esophagitis (EoE) a chronic, allergic inflammatory disease of the oesophagus.

The post Scotland backs Merck/Pfizer’s Bavencio combo for kidney cancer appeared first on .

from https://pharmaphorum.com/news/scotland-backs-merck-pfizers-bavencio-combo-for-kidney-cancer/

[abrreports-blog]

Burkitt Lymphoma Treatment Market Key Trends, Drivers, Growth Opportunities, and 2025 Industry Chain Structure Analysis

The research study Burkitt Lymphoma Treatment market 2020 launched by ABRReports.com provides the detailed analysis of current market status, investment plans, production and consumption, price trends, leading key companies, growth drivers and future prospect. The base year considered for the study is 2019, and the market size is projected from 2020 to 2025

 Get the Sample Copy of Burkitt Lymphoma Treatment market report at https://www.abrreports.com/industry-insights/2020-2025-global-and-regional-burkitt-lymphoma-treatment-industry-production-sales-and-consumption-status-and-prospects-professional-market-research-report?form=request-report-sample

 The segmentation of Burkitt Lymphoma Treatment study as mentioned below:

By Market Players:

AbbVie Inc, Arvinas, Inc., bluebird bio, Inc., Boehringer Ingelheim GmbH, Constellation Pharmaceuticals, Inc., Immunomedics, Inc., Karyopharm Therapeutics, Inc., Millennium Pharmaceuticals Inc, Patrys Limited, Seattle Genetics, Inc., Takeda Pharmaceutical Company Limited, Theravectys SA

 By Application

Hospital, Clinic, OthersARV-825, Alisertib, bb-2121, Ibrutinib, Others

 The points that are discussed within the report are the major market players that are involved in the market such as manufacturers, raw material suppliers, equipment suppliers, end users, traders, distributors and etc. The complete profile of the companies is mentioned. And the capacity, production, price, revenue, cost, gross, gross margin, sales volume, sales revenue, consumption, growth rate, import, export, supply, future strategies, and the technological developments that they are making are also included within the report. The historical data from 2014 to 2019 and forecast data from 2020 to 2025.

 The growth factors of the market are discussed in detail wherein the different end users of the market are explained in detail. Data and information by manufacturer, by region, by type, by application and etc, and custom research can be added according to specific requirements. The report contains the SWOT analysis of the market. Finally, the report contains the conclusion part where the opinions of the industrial experts are included.

 Click to access full report and Table of Content at https://www.abrreports.com/industry-insights/2020-2025-global-and-regional-burkitt-lymphoma-treatment-industry-production-sales-and-consumption-status-and-prospects-professional-market-research-report

 The key objective of this report is to help the user understand the market in terms of its definition, segmentation, market potential, influential trends, and the challenges that the market is facing. Deep researches and analysis were done during the preparation of the report. The readers will find this report very helpful in understanding the market in depth. The data and the information regarding the market are taken from reliable sources such as websites, annual reports of the companies, journals, and others and were checked and validated by the industry experts. The facts and data are represented in the report using diagrams, graphs, pie charts, and other pictorial representations. This enhances the visual representation and also helps in understanding the facts much better.

 Purchase the research study @  https://www.abrreports.com/industry-insights/2020-2025-global-and-regional-burkitt-lymphoma-treatment-industry-production-sales-and-consumption-status-and-prospects-professional-market-research-report/checkout?option=one

 Key pointers of the Table of Contents:

Chapter 1 Industry Overview

Chapter 2 Major Segmentation (Classification, Application and etc.) Analysis

Chapter 3 Production Market Analysis

Chapter 4 Sales Market Analysis

Chapter 5 Consumption Market Analysis

Chapter 6 Production, Sales and Consumption Market Comparison Analysis

Chapter 7 Major Manufacturers Production and Sales Market Comparison Analysis

Chapter 8 Marketing Channel Analysis

Chapter 9 Industry Chain Analysis

Chapter 10 Global and Regional Market Forecast

Chapter 11 Major Manufacturers Analysis

Chapter 12 New Project Investment Feasibility Analysis

Chapter 13 Conclusions

Continued…

 About Us:

ABR Reports (Advanced Business Research Reports) is the premium market research reselling company which offers market research reports to individuals, organizations and industries to enhance and strengthen the decision making process. With associate thoroughgoing list of market research Publishers we tend to cut across over all the business verticals covering 5000+ micro markets and offer market size and share analysis, industry trend, information on products, regional market and keen business insights to our clients.

 Contact Us:

Scott Harris

Sales Manager

Email ID: sales@abrreports.com

Phone No.: +1-561-448-7424 

[azveille]

ASH: AbbVie, Roche pad their case for fixed-duration Venclexta use in CLL

AbbVie and Roche have been fielding their fair share of questions about how well a fixed-duration regimen of Venclexta and Rituxan can keep chronic lymphocytic leukemia (CLL) from returning after therapy ends. The companies now think they have some compelling answers.

The duo posted an 81% reduction in the risk of disease progression or death at the four-year treatment mark, topping a pairing of Rituxan and bendamustine, the partners said Sunday at the American Society of Hematology (ASH) annual meeting.

The drug combo also put up higher rates of minimal residual disease-negativity, a commonly used metric in CLL that measures the number of leukemia cells remaining in the body after treatment.

In terms of extending lives, the Venclexta-Rituxan duo also cut the risk of death by 59%, and 68% of patients who received the combo were alive with their cancer still at bay 24 months after stopping therapy.

The performance “really demonstrates that there is no dropoff,” even after an additional year off of treatment, said Rod Humerickhouse, asset strategy leader at AbbVie.

"That brings a lot of confidence and really answers that key question for us: ‘Yes, you can stop,'" Humerickhouse added, "and those patients … who have achieved deeper responses, they are doing extremely well and are going to benefit from long periods of treatment-free remission.”

In the past, that level of response—which Humerickhouse called “front-line-like”—was mostly reserved for “the young, fit patients who could get the more aggressive chemo” in the relapsed or refractory setting, he said. But now, it’s “almost universally available with a fixed-duration treatment.”

With those efficacy numbers in tow, AbbVie and Roche are looking at the combination’s fixed duration as a positive for patients who don’t want constant reminders of their disease.

“I was a practicing hematologist previously, and I would have preferred to treat my patients with something that would be completed in a year and would give them a really deep response,” Roche Senior Vice President Nancy Valente said. “They can return to their lives rather than be reminded every day by taking a pill that they still have cancer and still need cancer therapy.”

“You essentially have a period where your life is normal,” Humerickhouse added, and “I think that is quite meaningful."

"Then we can even begin to talk about the value or cost of therapy that we aren’t realizing at the patient level or for the healthcare system as a whole," he said. "Fixed duration does bring a real value to many stakeholders."

Of course, there are other options—and those include therapy with BTK inhibitor Imbruvica (ibrutinib), the blockbuster cancer-fighter AbbVie shares with Johnson & Johnson’s Janssen unit. That drug, in tandem with Rituxan and bendamustine, bears a green light in previously treated patients.

But AbbVie is also working to combine the two blood cancer stars to treat newly diagnosed patients. Saturday at ASH, the phase 2 Captivate study showed marrying Imbruvica and Venclexta could effectively clear disease in more than 70% of patients.

“Continuous ibrutinib therapy is still the standard of care. I don’t think that’s changed,” said Mark Wildgust, VP of global medical affairs for oncology at Janssen. But with the Captivate results, “If you’re looking to try to find a CLL cell in the patients’ blood or bone marrow, it’s just not there in three quarters of them.”

If those results hold up in phase 3 trials and the regimen eventually scores a regulatory go-ahead, patients and their doctors will have some decisions to make, said Danelle James, head of clinical science at AbbVie’s Pharmacyclics business.

“It’s hard to beat the continuous therapy with ibrutinib in terms of progression-free survival just because it is a regimen that’s really beat all the other standards of care right now,” she said. But “if the patient doesn’t want to necessarily be monitored with labs or following their white count—they just want all their disease completely away—that’s where the regimen will be most compelling.”

For now, the companies still have plenty of questions to answer, SVB Leerink analyst Andrew Berens wrote in a weekend note to clients.

"Based on the data presented at the meeting, it is still unclear how many patients could stop treatment, and of those that discontinued the BTK regimen, whether their prognosis differed from the current standard of care, continuous BTK usage until progression," Berens said.

"We see the fixed-duration venetoclax regimen as primarily replacing the chemo-immunotherapy usage in CLL (FCR)," he said, "with BTK treatment remaining the cornerstone of frontline usage in the majority of patients, even without fixed-duration implementation."

[kristinsimmons]

Can we move on?

By CHADI NABHAN MD, MBA, FACP

Every so often, my cynical self emerges from the dead. Maybe it’s a byproduct of social media, or from following Saurabh Jha, who pontificates about everything from Indian elections to the Brexit fiasco. Regardless, there are times when my attempts at refraining from being opinionated are successful, but there are rare occasions when they are not. Have I earned the right to opine freely about moving on from financial toxicity, anti-vaxers, who has ‘skin in the game’ when it comes to the health care system, the patient & their data, and if we should call patients “consumers”? You’ll have to decide.

I endorse academic publications; they can be stimulating and may delve into more research and are essential if you crave academic recognition. I also enjoy listening to live debates and podcasts, as well as reading, social media rants, but some of the debates and publications are annoying me. I have tried to address some of them in my own podcast series “Outspoken Oncology” as a remedy, but my remedy was no cure. Instead, I find myself typing away these words as a last therapeutic intervention.

Here are my random thoughts on the topics that have been rehashed & restated all over social media outlets (think: Twitter feeds, LinkedIn posts, Pubmed articles, the list goes on), that you will simply find no way out. Disclaimer, these are NOT organized by level of importance but simply based on what struck me over the past week as grossly overstated issues in health care.  Forgive my blunt honesty.

●      Can we have fewer posts and papers that describe how immoral financialtoxicity is? We all know it’s a problem and our patients suffer the most from it. But continuing to mention the gravity of financial toxicity? Well, that’s just so 1999. At this point, I want more posts and papers discussing strategies on how we move forward. For example: How can we overcome financial toxicity? Even if our patients appreciate us continuing to discuss the same problems repeatedly, they deserve better answers from us.? Let me illustrate. Say I am your patient and I complain to you about persistent nausea. You, as the doctor are empathic and actively listen to my concern, yet my nausea persists. I appreciate the attention and the listening you offer, but at some point I need something to control my nausea. If you don’t have the remedy, I am more annoyed because you keep restating my problem, agonizing me further and still not offering me a solution or showing any attempts to try to find a solution for my issue.

●      I am growing tired of the debate on “vaccines”. Isn’t it clear that by now, if there are people who do not believe in vaccines, there is not much we can do to sway them differently? There comes a time when one must decide where to concentrate his/her energy. I am all for having an open dialogue. But, a dialogue with the intent of changing one’s opinion requires both parties to be open to each other’s views and that one of them might potentially change course. Based on what I have seen over the past few months, those opposed to vaccines will not be persuaded by strong evidence or the amount of data they are given. So, maybe we should direct our attention to something that brings better results? Say, describing financial toxicity one more time? OK, that was not nice.

●      There are many stakeholders in the health care industry, but the ultimate stakeholder is the patient. Aren’t we all previous patients, current patients, or future patients? I am growing tired of folks pointing fingers at each other as the solely responsible party for the current state of affairs. Academics blame pharma,  pharma blames research costs, insurers blame both, patients blame insurers, physicians blame the system, and the list goes on & on. We need to be fair and practical if we are to approach our health care system in a methodical way that lends towards some solutions. The reality is, EVERY entity is important in assuring proper delivery of life-saving drugs to patients who stand to benefit. We all can name hundreds of therapies that were developed outside the walls of academic and university labs, and similarly name many medication that required collaborations between academia and pharma to achieve success. Pharma defends itself from being the culprit, challenging us to envision how our current drug development and research ability is without the manufacturer’s taking risks? Would we have the “Gleevecs” of the world? Likely not. Could these drugs be much cheaper and could we have a more rational approach to drug pricing? Absolutely. But, hospital prices also need a better rationale for the costs of blood draws to x-rays, and the absurd costs of a Tylenol pill in an inpatient ward. Why do academicians rarely critique hospitals? Because they are employed by such hospitals. In general, it isn’t advisable to critique the employer that issues your paycheck. I plea that the critique must be fair, balanced, and equally distributed among all stakeholders.

●      Since we all know that a few patients are treated on clinical trials, we need to figure out a way to incorporate data generated from non-trial patients into decision-making. That’s what I call the “real world” Yes, it’s not perfect, but such is life. Less critique to the idea of studying the real-world and more thoughts of how we should analyze such imperfect data would be welcome. If I bet a dollar for every time I see a post contending “we all live in the real world; my world is real; there is no such unreal world”, I would be as rich as Jeff Bezos, before his divorce debacle. Bottom line, we live in the real world, so let’s embrace its imperfections and figure out how we proceed. We can’t answer every question with a randomized controlled trial; that’s just not doable. We can, however, learn from ‘patient Bob’ that encountered a toxicity not mentioned in a clinical trial; knowing that such toxicity can be seen in the real-world might help manage subsequent patients like ‘Bob’. For example, if we were to apply the aforementioned case to the real-world, when the initial study on Ibrutinib in CLL was published in NEJM, it did not report atrial fibrillation as a potential toxicity. However, now no CLL treater or a hematologist would dispute atrial fibrillation as a potential adverse event. I credit real-world data with this piece of information.  Let’s utilize ALL of our resources symphonically to optimize patient care. That should be our guiding principle.

●      I see many complain when patients are labeled as “consumers”  and when doctors are called “providers”. The sense is that these definitions demean both. I can understand this  viewpoint, but is this really a problem that is worth spending time on debating? Have we really resolved all health care issues such that we are now simply arguing whether we call ourselves providers or physicians? Wouldn’t that be luxurious? If labeling patients as “customers” or “consumers” of the health care system will force the system to accommodate patient’s needs, I am all for it. Why not? Whatever it takes to decrease wait times, improve satisfaction, and allow patients to enjoy the experience despite having an illness. If we view patients as “consumers” of what we have to offer, and recognize that consumers in any market have choices, maybe we would be incentivized to improve the subtle comforts in our health care delivery model. If the end goal is to maximize the patient experience, then let’s not get hooked on how we label this and that. As doctors, we “provide” healthcare service, expertise, help, listening ear, etc etc. Like it or not, we are “providers of health care”. Let’s refocus the debate on what best serves our patients and take a critical look at more pressing topics than nomenclature.

I am sure that every reader has his/her own laundry list like mine and the list changes based on whether the Patriots won, or if your coffee was made with cream or diluted almond milk. I shared some of my nuanced thoughts with you because I believe we have bigger problems to solve. We need action plans to help serve patients better, move the needle from talking about financial toxicity to solving it for the sick and vulnerable, and (yes, I mean everyone here) needs to collaborate and try to align our interest in recognizing that patients are the ultimate end user of the health care system. Thanks for indulging me as it was quite cathartic, and I might lobby to have a new laundry list of complaints every month (until I get blocked by the editor)!

Chadi Nabhan is an oncologist in Chicago. His interests include strategy and business of healthcare. He’s a prolific speaker and occasional tweeter. He can be reached @chadinabhan

Can we move on? published first on https://wittooth.tumblr.com/