#meropenem

[mymicrolab-mymicrobiology]

Meropenem: Trusted Antibiotic at MyMicroLab

Meropenem is a broad-spectrum antibiotic used to treat various bacterial infections. It’s typically administered via injection and is effective against a wide range of bacteria. However, it’s important to note that this medication should only be used under the guidance and prescription of a qualified healthcare professional.

If you have specific questions about Meropenem or if you’re looking for more information, it’s advisable to consult with a healthcare provider or pharmacist. They can provide personalized advice based on your medical history and condition.

And, of course, for any medical supplies or information related to Meropenem, you can explore the offerings at MyMicroLab. They may have a range of high-quality products related to microbiology and medical supplies.

[tajpharma2022]

#Meropenem for #Injection USP 1gm Technical Specification: #Product Name: #MeropenemInjection USP 1gm Strength:1gm Dosage Form: Dry #Powder #Injection (#Sterile) Packing:Vial + WFI Tray #Therapeutic use:β-lactam #Antibiotic, #Antibacterial, #Carbapenem Antibiotic

[hirayaea]

zayne reminds me of this cardiologist I worked with. he was older than me, very confident, pretty good looking and had very niche hobbies. I was his junior and we had a pleasant working relationship.

I was the on call in telemetry (the specialized cardiology ward), and one patient under his care was suffering from an infection. we had brought in the infectious specialist doctor and they prescribed an antibiotic and told me let’s wait and see if any bugs will grow from the blood cultures before we change it.

later that afternoon, the cardiologist comes in and asks me what the infectious specialist said, so I relay the advice that was given.

this cardiologist stares at me and says in very level voice, “no, let’s change the antibiotic, he’s really sick.”

I’m like: “are you sure?”

and he has the gall to smirk and say, “yeah, do you think the infectious doctor will get mad?”

me, in my head: YES!

me, in real life: “maybe?”

anyway he was very cute and maybe I should have fought harder to save both of us but I didn’t

the next day the infectious doctor came back and she was furious, she actually stormed out of the ward

(thankfully not at me, because dr. cardio actually wrote his name first in the sign off so I was saved)

the ending of this story is the cardiologist apologized and said Okay I Won’t Do It Again and the infectious doctor came back

/

anyway the point of this story is I still think zayne would order antiobiotics (specifically very high level ones like meropenem) without telling anyone because he seems like the type and now that I’m older I think I’d fight back ᕦ(ò_óˇ)ᕤ

[omkarmeds]

Darbepoetin Alfa injection - Where To Find The Best Store?

For one, in sourcing for injections, medications, vaccines or any other supplies for your medical practice, clinic, or hospital, you need a reliable Wholesaler and distributor. For CKD- and chemotherapy-related anemia, the useful injection type of treatment is darbepoetin alfa. Darbepoetin alfa as an effective erythropoiesis-stimulating agent helps increase red blood cell mass and minimizes requirement of RBC transfusions. Therefore, this article is very useful to help people find a good Darbepoetin Alfa injection wholesaler such as OmkarMedS that has a reasonable price.

OmkarMedS, is a prominent wholesaler and exporter of pharmaceutical products in India that offers a range of high-quality generic injectable drugs and formulations including darbepoetin alfa. Regardless of your medical injections supply requirements, OmkarMedS‘ goal is to bring affordable medicines to healthcare facilities, medical professions, and distributors worldwide.

OmkarMedS supplies all injections and infusion fluids from reliable manufacturers at reasonable prices for healthcare providers. Whether you require darbepoetin alfa or other critically needed generic injectables such as pegfilgrastim, iron sucrose, or methotrexate, you can get them from OmkarMedS’s extensive list of generic affordable prices. Being a reliable wholesaler, OmkarMedS guarantees that items are packed appropriately to arrive in a timely manner to enhance maximum patient care.

As a trusted injection wholesaler, OmkarMedS also guarantees:

Good quality control and clean and hygienic environment that are in compliance with the current cGMP requirements.

Large network of suppliers with sufficient stock to cater for market requirements

Effective cool chain product delivery mechanism

Doing business ethically and the issue of transparency

When you place your wholesale injections from OmkarMedS, you can be assured that what you receive from us is pure FDA approved injections that go through all the stringent tests as far as safety and potency are concerned. OmkarMedS then aims to meet every order as fast and quickly as possible through fast processing and dispatching.

Being one of the top darbepoetin alfa and pharmaceutical injection suppliers, OmkarMedS is always prepared to meet all your requirements and provide the necessary wholesale medicines. Call OmkarMedS today to find out more about how you can get started with our wholesale injection supplies and the services that help healthcare providers throughout India and beyond. Choose a reliable wholesaler, who will not only complement your efforts to improve the quality of treatment, but also to reduce its cost. If you are looking for Wholesaler of injections, consider visiting us!

[allmolecules]

Excellence in Health with Meropenem Injection Manufacturers in India

A broad-spectrum carbapenem antibiotic is meropenem. Both Gram-positive and Gram-negative bacteria are susceptible to its action. Meropenem works by easily entering bacterial cells and preventing the formation of essential cell wall components, which results in cell death. All Molecules is a pharmaceutical company with complete integration develops and Meropenem Injection Manufacturers in India. Our products are produced in WHO GMP Compliant Manufacturing Facilities with cutting-edge machinery.

[drdpharma]

DR.D Pharma - Meropenem Injection: Effective Antibiotic Treatment

DR.D Pharma presents Meropenem Injection, a powerful and reliable antibiotic medication designed to combat severe bacterial infections. With its broad-spectrum activity, Meropenem Injection effectively targets a wide range of bacteria, offering an excellent solution for critical medical conditions. Our product ensures high-quality and safety standards, delivering optimal efficacy in the treatment of complicated intra-abdominal infections, meningitis, pneumonia, and other severe infections. Trust DR.D Pharma's Meropenem Injection to provide efficient and dependable support for healthcare professionals in their mission to combat bacterial infections and improve patient outcomes.

[rklifecareinc]

Pharmaceutical Manufacturer Company | Tazobactam, Meropenem Manufacturer 

One of the best pharmaceutical manufacturing company in Delhi, India. Proving Sulbactam 500mg, Cefepime 1000 mg, Tazobactam 125 mg, Amoxicillin 1000 mg, Clavulanic Acid 200mg, Pantoprazole 40 mg, Rabeprazole 20 mg, cefotaxime 1000 mg, sulbactam 500mg, ceftriaxone Sodium 1000 mg, ceftriaxone Sodium 200 mg, sulbactam 125mg, ceftriaxone Sodium 1000 mg, sulbactam 500mg, ceftriaxone 1000mg, Tazobactam 125 mg, Cefoperazone Sodium 1000mg

[venusremediespharma]

Venus Remedies is one of the top Meropenem injections manufacturers in India. They have been manufacturing these injectable solutions for many years now and have gained a lot of experience in the process. The company takes pride in its ability to produce high-quality products that meet the needs of its customers. Venus Remedies is committed to providing the best possible experience to its customers and strives to provide them with the best possible value for their money. The company's products are available at very competitive prices and are backed by a team of highly skilled and experienced professionals.

Learn more: https://venusremedies.com/blog/venus-meropenem-manufacturer

[nerdgirlnarrates]

On the Value of Source Control:

ID Doc: what’s the best antibiotic?

Intern:……Meropenem?

ID Doc: wrong, it’s a good surgeon

[mindblowingscience]

Scientists at the Ineos Oxford Institute (IOI) have found a new potential combination therapy to combat antimicrobial resistance (AMR) by targeting two key bacterial enzymes involved in resistance. The study, "The Triple Combination of Meropenem, Avibactam, and a Metallo-β-Lactamase Inhibitor Optimizes Antibacterial Coverage Against Different β-Lactamase Producers," has been published in Engineering. Meropenem is a critical antibiotic used to treat serious multidrug-resistant infections like sepsis when other antibiotics such as penicillin have failed. However, this last resort drug is becoming less effective at treating infections due to antimicrobial resistance (AMR). One effective strategy to restore the activity of the antibiotic is to use a combination therapy to counter bacterial resistance mechanisms. An antibiotic combination treatment includes an antibiotic and an inhibitor. The inhibitor prevents bacterial enzymes such as metallo-β-lactamases (MBLs) and serine-β-lactamases (SBLs) from breaking down the antibiotic before it has its desired effect to treat the infection.

Continue Reading.

[flyonthewallmedstudent]

Q Fever

Aka, Query fever. What a weird name for a disease. Imagine telling people that's what you got.

in the 30s-40s, an Australian pathologist in QLD/Brisbane, came across an outbreak of the same or similar illness among abbatoir or slaughterhouse workers.

At the time, he called the disease "Q" fever or query as a temporary name until the pathogen could be identified. Unfortunately it stuck.

decades later, now nobel prize winner and virologist, MacFarlane Burnett isolated and identified the microbe responsible. I think this discovery contributed to his prize. i forget already.

Microbe responsible: Coxiella burnetti. Named for Burnett and HR Cox, the American bacteriologist who found the genus Coxiella where C burnetti falls under.

Initially they felt it was related to Rickettsia, responsible for Rocky Mountain Spotted Fever, but as science progressed, this was disproven.

Now for a Case Report

A 55 yo Italian man with a history of aortic valve replacement was diagnosed with pyrexia of unknown origin twice. Further signs included myalgias/splenomegaly/night sweats. The 2nd time he was admitted for PUO he deteriorated rather dramatically and was put on meropenem and teicoplanin.

A host of organisms was tested for on serological testing based on the man's travel and epidemiological history, all negative. Even a rheumatological panel was done, also less revealing. He also had a history of MGUS (a haem disoder), which is kind of a red herring here.

Cultures were negative, no vegetations were seen on a TTE - so they did consider IE. Which is an important differential for PUO.

Eventually a PET-CT was done (often favoured when investigations do not yield much for a sick patient with fevers), finally revealing a focus of infectious on his ascending aorta, where he'd also had previous surgery done. And in a round about way, they also further identified Coxiella Burnetti. He was treated doxycycline and hydroxychloroquine. As it's so rare in Italy, it wasn't really considered even though he mentioned rural travel.

Bottomline: Q Fever is an important consideration in the work up for culture negative IE. Further to this, always consider IE in the differentials for PUO particularly if they're at increased risk for IE (prosthetic valves, damaged valves, select congenital heart issues, previous IE). IE can present with night sweats, fevers, weight loss and splenomegaly. It can be insidious and chronic in nature. other risk factors can be more suggestive as we'll get into below.

Causative organism

Coxiella burnetti, it's a zoonoses - i.e. transmissible from animals. Special powers: very tough/hardy, can survive extreme environments (high temps and UV light etc.) over prolonged periods and is resistant to many common disinfectants/surface cleaners.

It's an intracellular pathogen and gram negative coccobacilli (PINK!)

name coccobaccili reminds me of cocopuffs.

it's mainly associated with farm animals, which the CDC so wholesomely displays on its website on Q fever (wtf).

goats, sheep, cattle typically (but many other animals, even birds, dogs and horses can be reservoirs)

in particular bodily fluids - amniotic fluid, placenta, faeces/urine, milk etc.

you can get it through unpasteurized milk and through inhaling it if it lands on dust in the area

ever visit a farm or petting zoo lately? OMG WASH YOU HANDS.

That said, it's typically inhaled in inorganic dust. You inhale it, it goes to the lungs, and then the bloodstream.

Increased risk for Coxiella burnetti (What to take on history of exposures and when to strongly consider it)

live on a farm or near one

exposure to a farm

work as a vet on a farm

farm worker, dairy workers, researchers on these animals/facilities

slaughterhouse/abbatoir

Also from CDC:

Clinical presentation

Most won't get sick after exposure and remain asymptomatic, a very small minority does. even though it is highly infectious.

incubation time is 2-3 weeks (consider this time in your history of exposure, did they work on the farm 2-3 weeks ago as opposed to yesterday).

Nonspecific acute infectious symptoms:

nonspecific systemic fevers/malaise/arthralgias/myalgias--> key is high fevers though and can be associated with headache and photophobia.

non specific GI - N/V/diarrhoea

respiratory ones - SOB or cough, consider it as atypical cause of community acquired pneumonia.

rare: hepatitis and jaundice (granulomatous) or encephalitis with neurological complications such as demyelinating disease or CN palsies, also haemolytic anaemia and HLH (yikes)

really it's the history of exposure that will lead you down the garden path to Q fever.

Chronic Q fever is perhaps worse, and can present as culture negative IE/PUO. Months/years later, as B symptoms as above above + LOW/LOA, night sweats. More likely to occur if you are predisposed for IE as above, have a weakened immune system for any reason, including pregnancy.

Chronic Q fever has a mortality of 10% if left untreated. About <5% of those with acute Q fever develop this if left untreated. Speculation is that it's more of an autoimmune process or abnormal immunological response to the bacteria.

To be honest, most who walk in the door with community acquired pneumonia get treated empirically for atypicals anyway, (standard course of doxycycline), so we hardly really ponder the question of Q fever in every patient. But if they present chronically and did not have atypical cover at the onset of acute symptoms, then it's something important to consider.

Other important conditions - can cause complications in pregnant women and 20% will get post Q fever syndrome. like chronic fatigue.

investigations

Serology! nice and easy. Look for IgG antibodies in the chronic presentation. Or PCR. Down side to serology - can take 2-3 days for the body to make said antibodies to the bacteria for detection. PCR can be done on any fluids/tissue sent.

Cultures useless, hence it fall under the umbrella of culture negative (hard to grow outside a host cell, it is an obligate intracellular pathogen).

Other hints on bloods (as serology/PCR takes time to return) - elevated or low platelet's, transaminitis with normal bili, opacities in CXR with hilar lymphadenopathy, CSF will show raised protein levels if done when encephalitis is suspected.

imaging can also support the diagnosis.. as illustrated by the case report.

Treatment

Acute disease - as standard for atypical bugs, doxycycline 100 mg BD for 14 days. Alternatives - TMP SMX or Clarithromycin.

Chronic Q fever or IE:

native valves: doxycycline and hydroxychloroquine (200 TDS) for 18 months

prosthetic: same but 24 months

why hydroxy: enhances the action of doxycycline (increases the pH of the phagolysosome)

Follow-up: look for 4 fold decrease in IGG

Sources:

CDC

Stat Pearls

Wiki as linked above

[posic-culture]

This is on the more nerdy side but posic culture is reading drug trials and cheering for the drug(s) being tested. Like yeah go meropenem go.

^

[hirayaea]

zayne is an A+ class man and honestly I love him, he was the reason I downloaded the game to begin with, but I think what’s stopping me from drowning in the brainrot is that I keep on thinking of him as my colleague and I just have a strong feeling we’d get into a disagreement about antibiotics

don’t ask me why it’s just the way he walks ok he looks like someone who would prescribe meropenem without asking

[omkarmeds]

Tips To Find a Reliable Commode chair dealers in Bangalore?

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In case of any query, to schedule a free demonstration and to know about our home delivery service, please feel free to call us now – Bangalore.

[allmolecules]

Pioneering Quality and Innovation in Meropenem Injection Manufacturers in India

Meropenem injection is a potent antibiotic used to treat serious bacterial infections. Commonly administered in hospitals, it is an essential tool in dealing with life threatening diseases such as pneumonia and sepsis. All Molecules is the best Meropenem Injection manufacturer in India