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rogueshadeaux · 2 years ago

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Chapter Twenty-Five — Fallout

It took me way too long to find my voice — I felt more disconnected from my body now than when I was freezing over. “When does it get easier?” I asked, voice croaky and barely there. “When do you stop feeling guilty over it?”

5,555 words [teehee] | 20 min read time | TRIGGER WARNINGS: violence, described spiraling, death, racism, illness

Brent pulled the sleeve of his sweater over the wrapping on his elbow as the phlebotomist, I’d discovered they’re called, filed away his blood samples in this tube holder, each one marked.

“Stress to them that I need the results as soon as they can get them,” Dr. Sims was talking off to the side with some technician. “The full report, in email.”

The tech muttered some agreement, clearly awestruck at who he was talking to, and was gone with the vials the moment they were handed off.

“So what’s a…microray?” Brent asked.

“Microarray,” Dr. Sims corrected. He was dressed differently today; business casual, collar of his dress shirt caught on the neckline of the wool sweater. “It’ll break down the sequencing of each individual chromosome and tell us if there’s any genetic malformations in your DNA,”

“And why would we need to know that?” Brent glanced over at Dad, who was sitting in the now-baren windowsill seats and looking out the window. Everything Dad and Brent had in this room was packed up, ready to go as soon as I got medicine from the in-hospital pharmacy.

Dad sighed hard, staring at the sky like it had all the answers for a moment longer before turning in place to face us. “There’s something I need to explain to you both,”

And then he began to tell us more about how Mom got sick.

She didn’t heal immediately after having us, but the doctors brushed it off; a Conduit has to be in decent shape to heal and she simply wasn’t. She lost a lot of blood in the abruption, and the blood transfusion had to be from someone without the Conduit gene as the enzymes are dangerous to normal people, so she may have been beyond drained out. That’s what they thought, at least. “They told us to give it a week,” Dad said, “That we’d probably see progress by then.”

They didn’t. Instead, Mom was discharged, and then back in the hospital nearly two days later for MRSA.

The Doctors contributed the infection to her weakened system, and brushed it off then as well. “When someone’s pregnant, their immune system is ass,” Dad tried to joke, with no real humor in his voice. “So they reset the healing clock on us. Told us to wait two weeks. Raising two newborns on my own when she was hospitalized was horrible, by the way,”

Two weeks came and went and her scar wasn’t gone. Her and Dad brought it up to her obstetrician, and they simply said to wait till her six week check-up. The amount of time it takes for someone normal to heal. “They did that again and again, a lot. Just told us to be patient and do it the human way,” Dad shook his head.

She began to bruise. She started getting bloody noses again. She had accidentally sliced a knuckle to the bone in a dishwashing accident and had to get stitches, which stuck around instead of dissolving almost immediately. “Healing was the first thing to disappear, and then her powers got weaker.”

Brent looked at me, fear in his eyes. “So does…does that mean Jean’s…”

“We aren’t sure yet.” Dr. Sims said. “That’s what the microarray is for. I was still in school when Fetch died — what was happening to her was what made me go in the first place. But that means we never found out what made her sick, and we’ve gotta rule out that it isn’t something genetic.”

“But didn’t you guys say it might be Augustine’s tar?” Brent asked.

“It might be,” Dad responded. “Which is where the second part of this conversation comes in.”

What the hell did that mean?

Dad took his jacket from his lap and chucked it on to the little backpack he had, hands going to his knees in its place. “Remember that holiday vacation I promised?”

What the hell did that mean? “Yeah?” I asked, glancing over at Brent with a cocked eyebrow. Was this like how people take out their dogs for the day before putting them down? Was I getting a ‘Best Day Ever’ before kicking the bucket? At least Brent seemed to be feeling the canine excitement; he was suddenly sitting perched at the end of my bed like he was waiting for Dad to ask him if he wanted to go for a walk.

Dad smiled slightly — though it looked more like a grimace. “Have either of you ever wanted to visit New Marais?”

Brent immediately cringed, and I couldn’t blame him. New Marais was…bad. Bad enough that Theresa’s mom basically fled from there after her dad was killed. I’m pretty sure it was the world capital for place most likely to get stabbed at. There were literal robbers poised at bridges, shooting the tires of cars on the highway to make them crash so they could pilfer everything from the vehicle. The only people that’d thrive in New Marais were criminals, extortionists, and other sorts of bloodsuckers. It wasn’t a pretty place, hadn’t been in literal decades; after the flood and the fascists, it had no allure. Unless you liked French colonial structures and being assaulted.

Even the architecture couldn’t convince Brent; he looked at me, and I knew we were thinking the same thing. “Why, uh…” I drew off. “Why New Marais?”

Dad wasn’t surprised at our apprehension — in fact, he seemed to agree with it. “There’s someone there that can help us out. Knows a bit about tar powers — but we have to be there to get answers. He’s outside of the city center, from what I understand, but it’s…”

“New Marais,” Brent said distastefully.

Dad nodded. “New Marais.”

“That’s still Louisiana,” I said, “That’s gotta be a couple hour flight, right?”

Dad grimaced. “Actually, it’ll be a…three day drive…”

“I’m not allowed to fly.” Dr. Sims said from his place, yet again, by the sink. “Not in planes, at least. I don’t plan on flying that far with my powers, either.”

“You’re coming with us?” Brent asked, an undertone of astonishment in his voice.

Dr. Sims nodded. “What’s happening to your sister is something I plan to see through. I didn’t get to…to help Fetch in time. I’m going to do it this time. It’s what she’d want.”

The way he talked, you’d think he and Mom were age-old friends. How well did they know each other?

The doctor came up with prescriptions, pain medicine and antibiotics and something else I couldn’t pronounce, giving directions I knew I’d forget the moment I left this room. Dad knew this too, saying, “I’ll put alarms on my phone — oh,” he reached down to the backpack, fiddling with the thing and pulling something out. “Put them on yours too.”

He tossed my phone towards my broken arm, forgetting I couldn’t exactly reach out and catch it with it held against my chest in the sling.

Dr. Sims slipped out at some point on promises that he’d be right back — and he was. Almost within three minutes. He was a bit winded, looking past Brent and I as he helped me figure out how to put on my jacket to look straight at Dad, saying, “We’ve got an issue,”

Dad’s face immediately got steely hard, and he stood, shoulders squared. “What’s up?”

“Not that kind of—” Dr. Sims cut off, “Well, it could be. Protest.”

Dad growled. “How the hell do they know we’re here?”

“Someone probably slipped something to the media,” Dr. Sims crossed the room in a second and was at the window, looking down at the parking lot a few floors below. “Might have seen you. Looks like they’re congesting the main entrance though, so we can probably slip out back. Problem is, none of us can get to the parking garage without them seeing,”

“It’s just a few protestors,” Brent shrugged. “We can get past them.”

“It’s…” Dr. Sims trailed off. “It’s more than a few.”

“One of us could go move the truck—” Dad started.

“They’ll just chase us down.”

“Is there a roof entrance?” Brent asked. “Maybe we can leave a different way, come back for the truck?”

Dad looked at him like he was an idiot. “I’m not letting your sister climb a hundred feet in the air when she can’t make the landing.”

I managed to balance the jacket on my shoulders, saying, “We should just go. Brent’s right, we’ve walked past them dozens of times before. There’s probably cops monitoring, we should be fine.”

Dad looked like he wanted to do anything, literally anything, except that. “If they get violent, Jean…” he warned.

Oh, God. Don’t tell me he’s turning into this sort of parent. “I can still defend myself, Dad.” I insisted. He wasn’t going to start keeping me in bubble wrap, right?

Dr. Sims actually came to my rescue. “We’ll all be there, she should be fine.”

“We can even escort her,” Brent added, amused. “Like some c-list celebrity.”

Dad bit at his cheek, unsure — but also entirely out of options. “Fine, okay,” He said. “We’ll move quick. Eugene, think you can guard Jean while she gets in the truck? I’ll cover Brent.”

Well, at least I wasn’t the only one he was being overprotective of. “Sure,” Dr. Sims said.

They found a formation when we stood in the elevators, just in case some people made it into the lobby of the hospital; Brent and Dr. Sims stood in front of me, flanking each side for space while Dad stayed behind me. A full cover of large, powerful bodyguards to make up for the fact that I was now weak. It felt so demeaning. I was some weak spot in the family now, a risk that they’d have to mind at all times.

As the elevator doors opened up into a hallway, I could hear them, a dozen voices, maybe even bordering on a hundred, all chanting angrily — although I couldn’t make out what. Brent cast an unsure look over his shoulder, asking, “Maybe we should stay a while?”

Dad’s face was steeled. “There’s no point.” he said plainly, a sudden shift from his hesitancy before. “The sooner we get out of here, the better.”

Still, as we passed an electronic map in the hall, Dad’s hand came out and drained it of all imagery, matching Dr. Sims in power.

The lobby was huge and fancy and white, with some big fountain fixture in the middle, its white noise barely doing anything to silence the voices. The windows, though, were big enough to show how many people there were. There were at least a hundred, all being forced to the sides by police so that the actual entrance to the hospital would be clear for patients and visitors, with three separate news vans recording the tension. “Fucking hell,” Dad muttered behind me.

“At least there’s cops?” I offered, not entirely sure that was a good thing. Rarely was.

“Stay looking forward, stay walking, don’t engage,” Dad listed off behind me. “You hear me, Brent? Don’t engage—”

“Yeah, yeah, I heard you,” Brent muttered, going a bit red.

The foyer of the hospital had a line of police whose eyes I avoided; just gotta stay in step and keep moving forward. Easy enough.

All of that assurance disappeared when we stepped outside to what was moments away from becoming an angry mob. But what I wasn’t prepared for was to be confronted with images of me; a grainy picture of me trying to get the huge concrete rock to not hit the helicopter, my Linus Pauling yearbook picture. The signs were all littered with words, accusations: Shot out of the sky on the ones with the footage, a sign with just the number 137 on it, the 7 written on a sticky note. An update on the death count.

Me. They were protesting me.

And as we stepped further into the light, the protestors zeroed in on me, and the general yelling became targeted insults that somehow melted into white noise and also stood out to me all at once. “Dirty Bio-terrorist!” one person yelled.

“There’s over fifteen thousand unemployed, I hope you’re happy!”

“You killed my brother!”

“We’re homeless now!”

“Someone oughta hold your head underwater!”

I didn’t realize I was frozen in place until Dad’s arm wrapped around me, and he began to roughly steer me through the slight divot in the crowd Dr. Sims and Brent’s bodies had made. “C’mon, Jean,” he muttered, voice as stiff as could be.

There was no getting through the crowd here; the flow of the protestors followed us like what I imagine wolves hunting elk did. But was it fair to paint them as the predators when they were the real victims here? If the Big Bad Wolf was on trial for the murder of those pigs, could you blame other swine for wanting to swallow him whole?

And that wasn’t an exaggeration; the crowd seemed to push closer in until they were claustrophobically close, until the heat of their insults warmed my skin. There was a shout, louder than the rest, and suddenly Brent was slamming himself into my side, arm steeled and shield up and I stumbled and yelled in pain. Something crashed against it with a musical ping, and a rather large decorative rock from the piles in the medians fell between his feet.

“The fuck, dude?” Brent shouted, swiping the rock up from his feet. He looked about ready to chuck it back, trying to get a good eye on whoever threw it.

“Things are getting out of hand,” Dr. Sims warned.

Dad tucked me closer into his side and walked faster, repeating under his breath again and again, “Stay looking forward, keep walking,” as if he was moments away from also going after people.

Brent stayed posted on my other side with his shield up all the way until we got to the entrance of the parking garage, people filtering around the entrance that was currently occupied by a few cars trying to either find parking or pay for it. Only protestors, though — all of those cops that had congregated the entrance? They were nowhere to be seen. The one running interference now was Dr. Sims, who stepped to the side, pushed us all into the stairwell, and then lifted his hands, blue light beginning to swirl around them.

“Eugene, what the hell are you doing?” Dad asked, pushing me up a step.

“Buying us some time. Go!” He demanded. “I’ll catch up.”

He waved those arms, and the air in front of him began to turn blue and solidify. Parts of it went silver like Brent, other parts stayed blue, and it began to take on a humanoid form when Dad pushed me again, forcing me up the stairwell.

Brent was in the lead, taking two at a time and looking back to watch me struggle to climb. God, the cut in my side was throbbing with each rough breath. Dad stayed behind me chanting encouraging reassurances, like “You’ve got this, Jeanie,” and “Last flight of stairs, c’mon.”

Thank god — I didn’t think I could go much farther.

Dad rushed us to his truck, opening the back door on the drivers’ side and forcing us both in there. “Brent, cover your sister for me. I’ll get us out of here,”

“Shouldn’t we wait for Dr. Sims?” Brent asked, crawling in awkwardly after me.

“He’ll catch up,” he reassured us.

Wasn’t sure how someone was supposed to catch up to a moving vehicle, but okay.

Brent’s shield was gone, but both arms were steeled now, covering my head and neck as he practically forced me to duck into his lap. I couldn’t see anything that was going on besides the shifts in light, but God, I could hear those protestors, louder than before and seemingly arguing with something. Did Dr. Sims…start a fight?

I peeked up from Brent’s lap just as the light shifted to see the protestors trying to fight their way into the parking garage against…eight tall, armored, blushed-blue winged angels.

“What the fuck?” I whispered, watching these angels levitate a mere ten inches off of the ground, refusing to part for the protestors — and cars — trying to come in.

“Get ready,” Dad warned us. Brent forced my head back down.

Dad honked the horn twice and there was a sudden collection of shouts from the protestors before Dad revved the engine and peeled out of there, throwing the truck so roughly right that I left Brent’s lap and nearly flew into the floorboard. There were more shouts, insults and curse words thrown our way that were drowned out by the truck’s roar and distance as Dad sped out of the area.

I stayed down for three minutes before Dad sighed hard and called back, “You’re good now, Jeanie.”

I could barely move. Those people, nearly a hundred people, came to the hospital to protest because I was there. Because of what I did.

“You okay?” Brent asked me.

I just stayed staring at the rock on the floorboard, the one aimed for me. How could I be okay?

We were well on the highway and nearly to the connection bridge that crossed to the other side of the Sound when the truck suddenly lurched as something slammed into the truck bed. Dad cursed as we both yelped, swerving in his lane so hard that the people beside us honked furiously as Brent and I spun around to see what happened.

Dr. Sims was in the bed face down, the groan audible from where we were despite the ambiance of rolling down the highway at 65 miles an hour.

“What the fuck was that?” Dad demanded, head whipping back to look at us and looking straight just as quickly as he moved to the right lane, slowing down.

“It’s uh,” Brent cocked his head. “It’s Dr. Sims? But he isn’t looking too good…”

He wasn’t looking anything. He hadn’t moved, face plastered in the lateral grooving of the truck bed.

Dad moved over until he was on the shoulder of the highway, putting the car in park and hopping out to check on Dr. Sims. “You good, Eugene?” he asked.

“Had to…couldn’t find you. Made an angel…fly me around. Out,” I could hear him groan through the window. “You’d think…I’d know how to land by now,”

“Well if your powers gave out, you couldn’t exactly stop it.” Dad shook his head. “C’mon, get in the truck,”

This was met by a loud groan that lasted for at least thirty seconds before Dr. Sims even tried to move a muscle.

Dr. Sims was now comfortably in the passenger's side seat of Dad’s truck, thanking him like a man parched when Dad sacrificed his phone for draining. “Does that not break it?” Brent asked.

Dad shook his head, glancing at us in the rearview mirror as Dr. Sims recovered. “Nah. Kinda just makes it short circuit for a while, but it’ll work again soon.”

Dr. Sims leaned his head back on the headrest, gasping out at the relief of the drain. “Thanks Del,”

“Sure. At least you have good aim,”

We were returning to Salmon Bay, but only for a moment; we were going to pack, maybe eat, and then start the thirty-nine hour drive to Louisiana. A multi-state trip that Dr. Sims and Dad began trying to plan as soon as Dad’s phone turned back on. “So it’s only a ten mile difference if we go right at Salt Lake City and take the highway to Denver,” Dr. Sims hummed. “Cuts through Wyoming,”

“We could make it a road trip?” Brent offered. “Yellowstone – could go to a Broncos game—”

“We’re…crunched for time, bud,” Dad said, casting a quick glance at me in his rearview mirror.

Right — I was the ticking time bomb now, the arsenal no one wanted around ‘cause it’d ruin days and maybe lives. I was holding the cool rock in my hand now that was aimed for my head, if what Brent chattered off at some point was true. I couldn’t even blame whoever threw it, not if they were impacted by what I did.

I was the cause of their discontent. They weren’t there to picket Dad or Dr. Sims, or Conduits in general with its two biggest leaders in the same place — but me. Not only for the deaths — people were screaming about losing their homes, their jobs. I may have killed one hundred and thirty-four — no, one hundred and thirty-seven, now — but I ruined the lives of so many more.

How many people were homeless now? How many people would have to scramble to live, to make money?

Salmon Bay wasn’t hurt, at least. That’s really all I could cling on to, was that they seemed relatively untouched. The Longhouse was roped off, and there were spots in the concrete that had been ripped up, but the wood chips and body were all wiped away.

Betty’s baby blue Beetle was in the house’s driveway, and it seemed the moment we turned down the street she was already racing out of the house, at Dad’s driver’s side in an instant and nearly yanking me out of the truck. “Oh, Regina!” She cooed, missing how I winced in pain as she gripped me tight around the abdomen. “You’re alright!”

Dad caught the grimace, gently peeling Betty off of me like you would a bandaid off of a toddler. “Okay, give her some room,” he chuckled under his breath.

Betty stepped back, shifting her hands to my shoulders and looking me over. She glanced over my shoulder at Dad with that look, that pathetically sad one that people reserved for children’s graves and oil-slick ducklings before wiping it clear off of her face and saying, “You need to eat! Come on, I made lunch.”

There was no convincing Betty I wasn’t hungry; she actually hovered near me until I took a bite of the grilled chicken she made before finally sauntering off, satisfied. The house was different; there was a new side table shoved in beside the couch, a television on the floor next to a propped-up mounting system. The kitchen had been entirely unpacked and had a bunch of unopened bulk cleaning supplies on the counters.

“Your family was meant to be the stars of the Potlatch,” Betty chimed in at some point. “A Potlatch is to share fortune among the tribe, and that’s what we planned to do for you all so that moving in would be more comfortable. Furniture, linens, the like — there were so many in the reservation that found something in good quality to donate. While you were…” She drew off, hesitating before going with, “In the hospital, I called in some favors and had everything moved in. In fact, I want to show you your room when you’re done!”

“We’re practically all moved in, now,” Dad added. “‘Course there’s probably a bunch of little things we’re forgetting, but for now, this is gonna be home.”

Yet another big change.

“Speaking of moving, though.” Dad added, taking a moment to chew on his food before continuing, “I found something when I was going through your stuff, Brent.”

Brent froze, fork midway to his mouth, and the blush from the cold outside almost immediately left his face as he paled. “Oh, really?” He tried to play cool.

Dad snorted, not ignorant to what he was doing. “Relax, you’re not in trouble. Not big trouble, anyways. But c’mon, man, why did you think having weed in a lawyer's house was a good idea? You know how deep of shit you would have gotten into if I found it before all of this?”

Brent blinked. “You’re…not mad?”

Dad barked out a laugh. “You really think I wasn’t smoking weed at your age? But Brent, son — it’s legal. You couldn’t wait till you were eighteen?”

Brent was still absolutely baffled at how this conversation was going, and I’m sure if we could hear the cogs in his brain, they’d be grinding so hard against each other that the sound would make us all cringe. “I’m…sorry?” he asked, not sure where he was supposed to go with this.

Dad shrugged. “Well, it doesn’t matter much, now. You have a higher metabolism, so getting high off of…regular stuff won’t be easy. That does not mean to try anything harder.” He stressed. “But if you plan on using dab pens, get ready to have to pull that fucker for a good eight minutes—”

“Delsin!” Betty chastised, Dr. Sims stifling a laugh from the couch.

Once they wound down and Dad mumbled his apologies, I spoke up, asking, “When do we leave?”

Dad hummed, thinking. “Tonight, probably. Less traffic, less people. We can all take turns too, since you two have your permit — well, you probably can’t Jean, but you could,” he directed towards Brent. “Eugene and I are gonna finish deciding which route we’re taking, and we’ll go after everyone packs.” He looked over his shoulder at Dr. Sims. “You’re sure you have everything you need?”

Dr. Sims shrugged. “For the most part. My laptops are still in your truck, and my go bag has enough supplies for a week without access to, say, washers or something. I don’t need much more.”

“I think I’m done,” I said, standing and abandoning the meal that was barely dug into. “I’m gonna go down to my room, start packing.”

“Oh! Let me show you where everything is—” Betty began, but I shook my head.

“It’s okay,” I assured her. “I can find it all. Kinda wanna lay down, too.”

Betty hesitated mid-step, shooting a look over to Dad, who seemed just as concerned. “You sure, Jeanie?” he asked.

I hated how they all were looking at me. “Yeah, Dad. I’m sure,” I said as lightly as I could, trying not to let my annoyance come through.

Dad slowly nodded, eyes not leaving mine. He was trying to analyze my poker face for something. “Alright. I’ll come check on you after we finalize a plan,”

Check on me. Like I couldn’t be left alone for too long without fear that I’d drop dead. “Yeah, sure,” I muttered, already turning around and heading down the hall. I ran away from their concern as quickly as I could, disappearing down into the basement and closing the door behind me, a small barrier between us all.

Betty really had put work into making the room feel less like squatting underneath a bridge and like an actual room; the mattress was now on one of those beds with storage cabinets underneath, my art chest sitting at its foot on the ground. There was a short, whitish dresser on one wall and a desk on the other, which I walked towards while pulling the rock from the protest out of my pocket, setting it on top of a bunch of random unopened school supplies.

Right! On top of everything, I was still in high school. Because things couldn’t get worse.

Well, no, they could. I knew exactly how they could, and how I could avoid it — but I didn’t. Why should I? I plopped down on the bed, threw off my arm sling, wrapped myself up in that woven blanket with Salmon in the middle and pulled out my phone.

Was it responsibility, curiosity, or just self-loathing that led me to wanting to look up more about the flood in Seattle? Probably all three. I needed to see what I did, how it impacted everyone because…didn’t I have a duty of care here? Didn’t I have a responsibility to care?

It would have been so much easier if I didn’t.

There was some footage from the fight from that helicopter, and that was really the only place I found anyone in my defense; the reporter, cameraman and pilot all lived, thank God, and it seemed like there were people in agreement that that was my initial plan. That’s where it ended, though.

There was a tag specifically for the tsunami everywhere, littered with people asking for donations to online fundraisers and if anyone knew which amnesty hotels still had rooms available. I hadn’t considered there would still be people missing too, unaccounted for in the chaos of recovery; .pdfs with faces and names and case numbers all littered the tag with family and friends begging them to come home. And the vitriol.

Another Rowe, ruining lives, one said.

There was a picture of my mom with a 289 above her, the image beside it of me at that art expo I won last year, side by side with the judges and Dad, 134 over it. The entire thing was titled apple doesn’t fall too far from the tree.

There were already politicians using what happened as their campaign fodder, speaking of how Conduits cannot be trusted to keep civilization safe if they’re able to live in it. “One Conduit has a bad day, and the body count is in the hundreds. A juvenile Conduit just killed over a hundred people in Seattle, injured thousands, and disrupted the lives of over seven hundred thousand people. This is a child who goes to school with your children, who doesn’t have control over their powers yet — what are we supposed to do when the next Conduit with absolutely no control over their abilities messes up? How can we trust we’re safe when these people don’t even seem to have control over themselves?”

Gotta get a new car because Tiger Lily flooded my brand new Mazda, one complained.

It’s gonna take more than identification, another tweeted. Pocahontas was stuck on a reservation and still managed to attack a big city. Biterrorists need to be carted off to some island.

He didn’t even spell Bio-terrorist right.

I could barely find the energy to get angry at the racism — how could I when the next post would be one for a funeral, or a wake, or just begging for someone, anyone, to tell the poster if their family member was alive?

And God, the obituaries. There was something bleak and horrifying about seeing one for a child that knocked the wind out of me so hard I began to hyperventilate to get it back. This was worse than the seven year old at COLE. There were dozens of children, old people and middle aged ones and people my age, barely adults. So many people died.

Waves began roaring in my ears as my breathing picked up, and while I was still looking straight at my phone screen, none of it made sense anymore. The words looked like nothing more than scribbles a child would do. That a child should be doing, not being lowered six feet into the ground or cremated or…

Oh, God, I couldn’t breathe.

I drew my legs into my chest and squeezed my eyes shut until they felt welded together, struggling to get in enough oxygen to feel like it was reaching my lungs. Fuck. A hundred and thirty seven people. All of this, all of this, was my fault. If I didn’t get caught by that Akuran, none of this would have happened. No one would be dead, our lives wouldn’t have been upended, maybe I’d even be able to heal without worrying why it was wrong — because if I didn’t know I was Conduit, I wouldn’t even feel like anything was wrong! My cast pressing into my chest wouldn’t feel like the squeeze of an anvil threatening to crush me whole. None of this would be happening, but it was, and it was my fault. My fault. My—

The bed moved, and someone settled in behind me, hands wrapping around the wrist dug into my hair and forcing it down to my chest, crossing it and grabbing my other arm the same way. I was gently leaned back, straightened from my curled form and pulled into a chest, and could barely hear Dad through the tinnitus in my ears. “You’re having a panic attack, Jean. I need you to breathe,” he commanded softly. “Use your stomach, not your chest.”

I tried to follow his instructions but it seemed to take two minutes just to get a neuron in my brain to spark hard enough to adjust how I breathed. Dad stayed there holding me, enveloping my little form, keeping me from doing anything else but concentrate on breathing.

My ears stopped ringing but began to sound like they were stuffed full of cotton balls, everything far away. Even as Dad’s soothing voice broke through my harsh hiccups, it felt like I was listening to him from underwater. His arms slackened their hold on mine, one leaving to pick up my phone as he whispered, “Oh, Jean,” before closing out the picture of a 10 year old’s obituary.

He shifted to my side, pulling me in so my ear was just over his heart. “I’m not sure,” he sighed. “It hasn’t gotten better for me.”

#infamous erosion #infamous second son #infamous #delsin rowe #Fetch Walker #sucker punch productions #eugene sims #who's busy being on the verge of passing out #We love him for it tho #YOU KNOW WHAT'S FUNNY #I WROTE THIS CHAPTER BEFORE MUSKS X BULLSHIT SO IDEK IF TWITTER WOULD BE AROUND IN 2037 #pretend it was bought out by Yahoo and abandoned or smthn idk

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screenshots123 · 2 years ago

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The study, published Jan. 24 in Nature, shows that approximately 20% to 25% of patients with multiple sclerosis have antibodies in their blood that bind tightly to both a protein from the Epstein-Barr virus, called EBNA1, and a protein made in the brain and spinal cord, called the glial cell adhesion molecule, or GlialCAM.

“Part of the EBV protein mimics your own host protein — in this case, GlialCAM, found in the insulating sheath on nerves,” said William Robinson, MD, PhD, professor of immunology and rheumatology at Stanford. “This means that when the immune system attacks EBV to clear the virus, it also ends up targeting GlialCAM in the myelin.”

Myelin forms the protective coating around nerve cells, and when it’s damaged, electrical impulses can no longer jump efficiently from one nerve to the next, resulting in the numbness, muscle weakness and severe fatigue of multiple sclerosis. Previous research has shown that multiple sclerosis patients have increased antibodies to a variety of common viruses, including measles, mumps, varicella-zoster and Epstein-Barr virus. In fact, more than 99% of MS patients have EBV antibodies in their blood, indicating a prior infection, compared with 94% of healthy individuals. But despite this epidemiologic correlation, scientists have struggled to prove a causal connection.

“Nobody really knows what causes autoimmune diseases, and for many decades, all sorts of different viruses have been hypothesized,” Robinson said. “But when people did further mechanistic digging, everything fell apart, and it turned out that getting those other viruses didn’t actually cause MS.”

To search for this elusive mechanistic link, the researchers started by examining the antibodies produced by immune cells in the blood and spinal fluid of nine MS patients. Unlike in healthy individuals, the immune cells of MS patients traffic to the brain and spinal cord, where they produce large amounts of a few types of antibodies. Patterns of these antibody proteins, called oligoclonal bands, are found during analysis of the spinal fluid and are part of the diagnostic criteria for MS.

“No one knows exactly what those antibodies bind to or where they’re from,” Robinson said. “So the first thing we did was analyze the antibodies from the oligoclonal bands, and showed that they come from B cells in the spinal fluid.”

Lanz said. “What we did was a different approach: We took B cells from the spinal fluid, single-cell sorted them and sequenced each one separately. In a single-cell format and at the scale of tens to hundreds of B cells per patient, that had not been done before.”

Once the researchers determined that the oligoclonal bands in MS are produced by the sorted B cells in the spinal fluid, they expressed individual antibodies from these cells and tested them for reactivity against hundreds of different antigens.

“We started with human antigens,” Robinson said, “but couldn’t find clear reactivity. So eventually we tested them against EBV and other herpes viruses, and lo and behold, several of these antibodies, and one in particular, bound to EBV.”

Six of the nine MS patients had antibodies that bound to the EBV protein EBNA1, and eight of nine had antibodies to some fragment of EBNA1. The researchers focused on one antibody that binds EBNA1 in a region known to elicit high reactivity in MS patients. They were then able to solve the crystal structure of the antibody-antigen complex, to determine which parts were most important for binding.

Before this discovery, Robinson said he’d been unconvinced that EBV caused MS. “We all thought it was just kind of an artifact; we didn’t really think it was causative. But when we found these antibodies that bound EBV in the spinal fluid, produced by the spinal fluid B cells, it made us revisit the potential association that we’d dismissed.” Next, the researchers tested the same antibody on a microarray containing more than 16,000 human proteins. When they discovered that the antibody also bound with high affinity to GlialCAM, they knew they’d found a specific mechanism for how EBV infection could trigger multiple sclerosis.

“EBV tricks the immune system into responding not only to the virus, but also to this critical component of the cells that make up the white matter in our brains,” Steinman said. “To use a military metaphor, it’s like friendly fire: In fighting the virus, we damage our own army.”

To find out what percentage of MS might be caused by this so-called “molecular mimicry” between EBNA1 and GlialCAM, the researchers looked at a broader sample of MS patients and found elevated reactivity to the EBNA1 protein and GlialCAM in 20% to 25% of blood samples in three separate MS cohorts.

“Twenty-five percent is a conservative number,” Robinson said, noting that it doesn’t include patients who may have previously reacted to GlialCAM following EBV infection but whose immune response has evolved since the initial trigger.

In fact, a study of 801 MS cases from more than 10 million active-duty military personnel over 20 years found that EBV infection was present in all but one case at the time of MS onset. A paper describing that study, published this month in Science, found that of 35 people who were initially EBV-negative, all but one became infected with EBV before the onset of MS. In addition, this separate group of researchers identified the same EBNA1 region as a major antibody target in MS patients. Together with the discovery of EBNA1/GlialCAM cross-reactivity, this data provides compelling evidence that EBV is the trigger for the vast majority of MS cases, as Robinson and Steinman point out in a Science Perspective, also published in January.

📅 Jan 2022 📰 Study identifies how Epstein-Barr virus triggers multiple sclerosis

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swati3191 · 4 days ago

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Culture Centers in Genetics Labs: What They Are and Why They're Crucial

In the high-tech world of modern genetics, we often hear about sequencing, DNA analysis, and bioinformatics. But behind many of these advances lies a quiet yet powerful foundation — the culture center. These specialized laboratory units are where cells are nurtured, studied, and tested, making them indispensable to both research and clinical diagnostics.

At Greenarray Genomics Research and Solutions Pvt. Ltd., our in-house culture center plays a key role in supporting cutting-edge cytogenetic and molecular biology services. But what exactly is a culture center, and why is it so essential in genetic science?

🧫 What Is a Culture Center?

A culture center is a controlled laboratory space where human cells or tissues are grown under sterile and optimal conditions for observation, analysis, or experimentation. This process, known as cell culture, allows scientists to:

Monitor cell behavior

Perform chromosomal analysis (karyotyping)

Detect genetic abnormalities

Prepare samples for further molecular testing

These cultured cells provide a living system to study how genes function, mutate, or express in real-time — especially critical for diagnostics and therapeutic development.

🔬 Why Culture Centers Matter in Genetic Labs

Culture centers serve as the backbone for several advanced genetic and diagnostic services:

1. Prenatal Cytogenetic Testing

Purpose: To detect chromosomal abnormalities in the fetus, such as Down syndrome, Turner syndrome, or structural changes.

How culture helps: Amniotic fluid or chorionic villus samples are cultured to grow fetal cells, which are then examined under a microscope.

Outcome: Accurate detection of chromosomal conditions early in pregnancy.

2. Cancer Cytogenetics

Purpose: To identify chromosomal abnormalities in leukemia, lymphoma, or solid tumors.

How culture helps: Blood or bone marrow cells are cultured to identify translocations, deletions, or duplications linked to cancer.

Outcome: Guides diagnosis, prognosis, and treatment planning.

3. Infertility and Reproductive Genetics

Use: Analysis of chromosomal anomalies in individuals with recurrent pregnancy loss or infertility.

Benefit: Helps couples understand underlying genetic causes and plan future pregnancies.

4. Rare Genetic Disorders

Culture-based studies enable karyotyping and FISH (Fluorescence In Situ Hybridization) testing, which are vital for identifying structural or numerical chromosomal disorders.

⚙️ What Makes a Good Culture Center?

A reliable culture center must ensure:

Sterile, contamination-free environment

Optimal growth conditions (temperature, humidity, CO₂ levels)

Skilled technicians trained in sample handling and cell care

State-of-the-art equipment for incubation, harvesting, and slide preparation

Strict quality control for reproducibility and accuracy

At Greenarray Genomics, our culture center is meticulously designed with these principles, ensuring high-quality cytogenetic preparations and diagnostic precision.

🧭 Our Commitment at Greenarray

Under the visionary leadership of Dr. Sanjay Gupte, Greenarray Genomics in Pune integrates culture center capabilities with advanced genetic services like:

Next Generation Sequencing (NGS)

Hereditary cancer screening

Prenatal and carrier testing

Chromosomal microarray and FISH diagnostics

By combining cell culture, cytogenetics, and molecular analysis, we ensure a comprehensive diagnostic pathway that is precise, patient-centric, and future-ready.

🌱 Conclusion: Small Cells, Big Impact

Culture centers may operate behind the scenes, but their role is central to unlocking genetic mysteries. By providing living cells for analysis, they bridge the gap between raw genetic material and real-world diagnosis — often marking the first step toward life-changing insights.

#Culture Centers in Genetics Labs

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fuzzycrownking · 12 days ago

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Array Instruments Market Drivers Enhancing Healthcare and Pharmaceutical Diagnostic Capabilities Rapidly

The Array Instruments Market in Healthcare and Pharmaceuticals is witnessing significant transformation, driven by a combination of technological evolution and growing healthcare demands. These instruments, essential in genomics and proteomics, are crucial for high-throughput analysis, gene expression profiling, and biomarker discovery. Below are the primary drivers influencing the expansion and modernization of this market.

Rising Demand for Precision and Personalized Medicine One of the most influential drivers of the array instruments market is the global shift towards precision medicine. With increasing awareness of genetic variability and its impact on disease manifestation and drug response, healthcare systems are rapidly incorporating genomics-based diagnostics. Array instruments, especially DNA and protein microarrays, are vital in identifying genetic mutations, facilitating targeted therapies. In the pharmaceutical sector, this technology supports companion diagnostics, ensuring that medications are matched accurately to individual genetic profiles, thereby enhancing treatment efficacy.

Surge in Chronic and Genetic Disorders A global rise in chronic diseases such as cancer, cardiovascular disorders, and genetic conditions is accelerating the demand for array-based diagnostics. Cancer diagnostics, for instance, often rely on gene expression arrays to detect mutations or abnormal expressions. In 2023, over 20 million new cancer cases were reported worldwide. The use of array instruments helps clinicians and researchers understand disease at a molecular level, making them indispensable tools in modern healthcare.

Technological Advancements and Automation The integration of automation and AI into array-based platforms has greatly improved the accuracy, efficiency, and reproducibility of results. Automated systems minimize manual errors, reduce turnaround time, and allow the processing of thousands of samples simultaneously. Additionally, the rise of bioinformatics and cloud computing is enhancing the analytical capabilities of array instruments, enabling researchers to derive meaningful insights from vast datasets. This technological growth is encouraging pharmaceutical companies to invest heavily in array technologies for drug discovery and development.

Increased Government and Private Funding Government initiatives and private investments in genomics research and biotechnology are key drivers for the array instruments market. National genome projects, healthcare modernization programs, and funding from agencies like NIH and WHO have created robust infrastructure and encouraged the adoption of genomic technologies. Pharmaceutical companies are also increasing their R&D budgets, especially in genomics and precision drug development, thereby pushing the demand for sophisticated array tools.

Widespread Adoption in Drug Discovery and Development Array instruments play a pivotal role in the pharmaceutical industry, especially in the early stages of drug discovery. They are employed to study gene expression patterns, identify potential drug targets, and analyze drug response mechanisms. This helps in accelerating the drug development process and reducing the costs and time associated with traditional trial-and-error methods. As drug pipelines grow more complex and patient-specific, array instruments are becoming essential tools for pharmaceutical R&D labs.

Emerging Applications in Infectious Disease Management Infectious diseases, particularly emerging and re-emerging viruses, are another significant driver. Array instruments have been used in recent years for pathogen identification, especially during the COVID-19 pandemic. Their ability to provide rapid, multiplexed analysis made them crucial for tracking viral mutations and understanding immune responses. This has increased their value in epidemiological research and public health diagnostics, with healthcare systems worldwide investing in these technologies for preparedness and monitoring.

Growing Utility in Academic and Clinical Research Universities, research institutes, and clinical laboratories are increasingly adopting array instruments for various applications, including gene mapping, mutation detection, and tissue-specific gene expression analysis. As academic collaborations with pharmaceutical companies intensify, the demand for reliable and scalable array platforms continues to rise. This has created a mutually beneficial ecosystem, where innovation in academia feeds the practical applications in clinical and pharmaceutical settings.

Conclusion The array instruments market is underpinned by a robust set of drivers, ranging from the rise of personalized medicine and chronic diseases to technological innovation and funding support. As both healthcare and pharmaceutical industries lean more on genetic and proteomic insights, the relevance and demand for array instruments are only expected to increase. Stakeholders in this market are positioned for growth, especially those that prioritize innovation, automation, and clinical integration.

#ArrayInstrumentsMarket #HealthcareInnovation

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aimarketresearch · 1 month ago

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Single-Cell Genome Sequencing Market Size, Share, Trends, Growth Opportunities and Competitive Outlook

Single-Cell Genome Sequencing Market - Size, Share, Demand, Industry Trends and Opportunities

Global Single-Cell Genome Sequencing Market, By Type (Instruments and Reagents), Technology (NGS, PCR, Q-PCR, Microarray, and MDA), Workflow (Single Cell Isolation, Sample Preparation, and Genomic Analysis), Disease Area (Cancer, Immunology, Prenatal Diagnosis, Neurobiology, Microbiology, and Others), Application (Circulating Cells, Cell Differentiation, Genomic Variation, Subpopulation Characterization, and Others), End User (Academic and Research Laboratories, Biotechnology and Biopharmaceutical Companies, Clinics and Others) – Industry Trends.

Access Full 350 Pages PDF Report @

**Segments**

- **Product**: The single-cell genome sequencing market can be segmented based on product into consumables, instruments, and software & services. Consumables include reagents, kits, and other materials required for sequencing experiments. Instruments refer to the sequencing machines and equipment used for single-cell genome sequencing, while software & services include data analysis tools and sequencing services offered by companies. - **Technology**: Segmentation based on technology includes next-generation sequencing (NGS) and polymerase chain reaction (PCR) technologies. NGS allows for high-throughput sequencing of multiple single cells simultaneously, providing detailed genomic information. PCR-based methods, on the other hand, are useful for amplifying specific DNA sequences in single cells. - **Application**: The market can also be segmented based on applications such as oncology, immunology, microbiology, neurology, and others. Single-cell genome sequencing is utilized in various research areas to understand the genetic heterogeneity of cells and their implications in disease development and treatment.

**Market Players**

- **Illumina, Inc.**: As a leading player in the genomics industry, Illumina offers a range of solutions for single-cell genome sequencing, including the NovaSeq platform and related consumables. The company's advanced sequencing technologies and data analysis tools are highly sought after in research and clinical settings. - **10x Genomics**: Known for its innovative single-cell sequencing solutions, 10x Genomics provides a comprehensive suite of products for analyzing single-cell genomes. The company's Chromium System is widely used for high-throughput single-cell transcriptomics and genomics studies. - **Thermo Fisher Scientific**: With a diverse portfolio of sequencing instruments and reagents, Thermo Fisher Scientific is a key player in the single-cell genome sequencing market. The company's Ion Torrent and Applied Biosystems platforms are popular choices for researchers conducting single-cell sequencing experiments. - **Bio-Rad Laboratories, Inc.**: Bio-Rad offers a range of products for single-cell genome sequencing, includingBio-Rad Laboratories, Inc. is a prominent player in the single-cell genome sequencing market with its cutting-edge technologies and innovative solutions. The company's expertise lies in providing robust tools for studying genetic diversity at the single-cell level. Bio-Rad's products cater to a wide range of research applications, including oncology, immunology, and microbiology, enabling researchers to delve deep into the complexities of cellular heterogeneity and disease mechanisms. The company's sequencing platforms and reagents are known for their accuracy, efficiency, and reliability, making them valuable assets in advancing genomic research.

In the competitive landscape of the single-cell genome sequencing market, Bio-Rad Laboratories, Inc. stands out for its commitment to technological advancements and customer-centric solutions. The company's continuous efforts in developing user-friendly and high-performance instruments have garnered a loyal customer base among researchers and scientists globally. By focusing on delivering comprehensive workflows that streamline the single-cell sequencing process, Bio-Rad has established itself as a trusted partner in the genomics community.

Moreover, Bio-Rad's strong emphasis on research and development initiatives ensures that its product portfolio remains at the forefront of innovation in the single-cell genome sequencing market. The company invests significantly in exploring new technologies and methodologies to enhance the efficiency and accuracy of single-cell sequencing experiments. By staying ahead of industry trends and customer demands, Bio-Rad maintains a competitive edge and sustains its position as a key player in the genomics sector.

Furthermore, Bio-Rad Laboratories, Inc. excels in providing comprehensive customer support and training programs to assist researchers in harnessing the full potential of its single-cell genome sequencing products. The company's commitment to empowering scientists through education and training initiatives underscores its dedication to advancing genomic research and discovery. By offering tailored solutions and personalized assistance, Bio-Rad ensures that researchers can achieve their scientific goals effectively and efficiently.

In conclusion, Bio-Rad Laboratories, Inc. plays a vital role in driving innovation and progress in the single-cell genome sequencing market. With its state**Global Single-Cell Genome Sequencing Market Analysis**

- **Segments:** - **Product:** The market can be segmented into consumables, instruments, and software & services. - **Technology:** Segmentation includes NGS and PCR technologies. - **Application:** Segments such as oncology, immunology, microbiology, neurology, etc.

**Market Trends:** The global single-cell genome sequencing market is witnessing rapid growth due to increasing research activities in understanding cellular heterogeneity and disease mechanisms. Technological advancements in NGS and PCR technologies have fueled market expansion, allowing for high-throughput sequencing and detailed genomic analysis at the single-cell level. The growing applications of single-cell genome sequencing in areas like oncology and immunology are driving market demand as researchers aim to uncover genetic variations and subpopulation characteristics for targeted therapies and precision medicine.

**Market Drivers:** Key drivers of market growth include the rising prevalence of cancer and other complex diseases, driving the need for precise genomic analysis at the single-cell level to develop personalized treatment strategies. Additionally, the increasing investment in genomics research and advancements in bioinformatics tools are propelling market expansion. The collaborative efforts between industry players and research institutions to enhance sequencing technologies and data analysis capabilities are further boosting market growth.

**Market Challenges:** Despite the market opportunities, challenges such as high costs associated with single-cell sequencing technologies and data analysis tools may hinder market growth, particularly in emerging economies. Moreover, the complexity of analyzing single-cell data and

The report provides insights on the following pointers:

Market Penetration: Comprehensive information on the product portfolios of the top players in the Single-Cell Genome Sequencing Market.

Product Development/Innovation: Detailed insights on the upcoming technologies, R&D activities, and product launches in the market.

Competitive Assessment: In-depth assessment of the market strategies, geographic and business segments of the leading players in the market.

Market Development: Comprehensive information about emerging markets. This report analyzes the market for various segments across geographies.

Market Diversification: Exhaustive information about new products, untapped geographies, recent developments, and investments in the Single-Cell Genome Sequencing Market.

Global Single-Cell Genome Sequencing Market survey report analyses the general market conditions such as product price, profit, capacity, production, supply, demand, and market growth rate which supports businesses on deciding upon several strategies. Furthermore, big sample sizes have been utilized for the data collection in this business report which suits the necessities of small, medium as well as large size of businesses. The report explains the moves of top market players and brands that range from developments, products launches, acquisitions, mergers, joint ventures, trending innovation and business policies.

The following are the regions covered in this report.

North America [U.S., Canada, Mexico]

Europe [Germany, UK, France, Italy, Rest of Europe]

Asia-Pacific [China, India, Japan, South Korea, Southeast Asia, Australia, Rest of Asia Pacific]

South America [Brazil, Argentina, Rest of Latin America]

The Middle East & Africa [GCC, North Africa, South Africa, Rest of the Middle East and Africa]

This study answers to the below key questions:

What are the key factors driving the Single-Cell Genome Sequencing Market?

What are the challenges to market growth?

Who are the key players in the Single-Cell Genome Sequencing Market?

What are the market opportunities and threats faced by the key players?

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industryresearchnew · 2 months ago

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Multiplex Immunoassays Revolutionize Diagnostics: Market Insights 2025

The healthcare and diagnostic sectors have seen remarkable advancements in recent years, with significant breakthroughs improving the accuracy and speed of disease detection. One such innovation making a notable impact is multiplex detection immunoassays. These assays enable simultaneous detection of multiple biomarkers in a single sample, revolutionizing diagnostics, research, and therapeutic monitoring. As healthcare providers and researchers seek faster, more efficient ways to diagnose diseases, the multiplex detection immunoassay market is witnessing rapid growth. This article delves into the trends, drivers, challenges, and opportunities in the multiplex detection immunoassay market, offering insights into the future of diagnostics.

Understanding Multiplex Detection Immunoassays

Multiplex detection immunoassays are diagnostic tests that can measure the presence of multiple biomarkers (such as proteins, antibodies, or nucleic acids) in a single sample, typically blood, urine, or tissue. Unlike traditional assays that analyze one biomarker at a time, multiplex assays allow for the simultaneous detection of various markers, which improves diagnostic efficiency and enables more comprehensive profiling of diseases.

The underlying technology of multiplex immunoassays typically involves antibodies or antigens that bind specifically to target biomolecules. These interactions are then detected through various mechanisms, including fluorescence, chemiluminescence, colorimetric assays, or electrochemical detection. The simultaneous detection of multiple targets from the same sample is achieved by using different markers or labels, which are distinguishable from one another.

Multiplex detection immunoassays are used in a wide range of applications, including disease diagnostics, drug development, cancer detection, infectious disease monitoring, and monitoring autoimmune diseases. Their ability to deliver rapid, reliable results while reducing the need for multiple individual tests has garnered increasing attention from healthcare providers, researchers, and pharmaceutical companies alike.

Drivers of Market Growth

Rising Demand for Personalized Medicine

Personalized medicine, which tailors treatment based on an individual’s unique genetic makeup, is transforming the healthcare landscape. The need for comprehensive diagnostic tools that can provide detailed information about a patient’s condition has made multiplex detection immunoassays a crucial component of this trend. By simultaneously measuring multiple biomarkers, these assays provide a holistic view of a patient’s health, enabling more targeted and precise treatments. This, in turn, is driving the demand for multiplex assays in clinical and research settings.

Increasing Prevalence of Chronic Diseases

The growing global prevalence of chronic diseases such as cancer, diabetes, cardiovascular diseases, and autoimmune disorders is another significant driver of the multiplex detection immunoassay market. These diseases often require regular monitoring of several biomarkers, and multiplex assays can offer a cost-effective and time-efficient solution. Additionally, the need for early diagnosis and personalized treatment options in chronic disease management has led to greater adoption of multiplex assays in clinical practices.

Advancements in Technology and Automation

Technological advancements in multiplex detection immunoassay platforms, including automation and miniaturization, have made these assays more accessible and user-friendly. New developments in microfluidics, microarray technologies, and biosensors have enhanced the sensitivity, accuracy, and speed of multiplex assays. These innovations have also made it easier for laboratories to handle larger volumes of samples, further boosting the demand for multiplex detection systems.

Increased Investment in Research and Development

The pharmaceutical and biotechnology sectors are investing heavily in research and development to discover new biomarkers for various diseases. Multiplex detection immunoassays play a critical role in biomarker discovery and validation by enabling the simultaneous screening of multiple markers in a single experiment. This is encouraging academic institutions, pharmaceutical companies, and contract research organizations (CROs) to adopt these assays in their research workflows, driving market growth.

Faster Diagnostics and Reduced Costs

Multiplex detection immunoassays offer significant cost advantages by reducing the need for multiple individual tests and enabling faster turnaround times. As healthcare systems globally face pressure to improve efficiency and reduce costs, these assays are becoming an attractive option. Furthermore, the ability to analyze several biomarkers from a single patient sample reduces patient discomfort and the overall time spent on diagnostic procedures.

Key Applications of Multiplex Detection Immunoassays

Cancer Diagnostics and Monitoring

Cancer remains one of the most significant health challenges worldwide, with early detection and personalized treatment being critical for improving patient outcomes. Multiplex detection immunoassays are increasingly used in oncology for the simultaneous detection of multiple tumor markers, enabling more accurate cancer diagnosis, monitoring of treatment response, and identification of recurrence. For instance, a multiplex assay might analyze markers associated with various cancers, such as prostate-specific antigen (PSA) for prostate cancer or CA-125 for ovarian cancer.

Infectious Disease Diagnosis

The demand for multiplex assays in infectious disease diagnostics has surged, particularly in the wake of the COVID-19 pandemic. Multiplex assays can simultaneously detect multiple pathogens, including viruses, bacteria, and fungi, in a single patient sample. This is especially valuable in regions with limited access to healthcare or in situations where rapid, on-site diagnostics are needed. Applications in infectious disease include testing for respiratory pathogens like influenza and COVID-19, as well as sexually transmitted infections (STIs), vector-borne diseases, and emerging infectious diseases.

Autoimmune Disease Monitoring

Autoimmune diseases, such as rheumatoid arthritis, lupus, and multiple sclerosis, involve the immune system mistakenly attacking the body’s tissues. Multiplex assays are used to measure multiple autoantibodies and cytokines, aiding in the diagnosis, monitoring, and management of these conditions. By assessing several biomarkers at once, clinicians can obtain a more comprehensive understanding of a patient’s autoimmune profile, improving treatment strategies and outcomes.

Infectious Disease Surveillance

Public health authorities use multiplex detection immunoassays to track the spread of infectious diseases in populations. These assays can detect multiple pathogens in surveillance programs, enabling more efficient outbreak management and response. Whether monitoring seasonal flu strains or emerging infectious threats, multiplex assays provide real-time insights into public health trends.

Drug Development and Clinical Trials

Multiplex detection immunoassays are invaluable in the pharmaceutical industry, particularly in drug development and clinical trials. By enabling researchers to simultaneously assess multiple biomarkers related to drug efficacy, toxicity, and pharmacokinetics, multiplex assays accelerate the drug discovery process and improve clinical trial design.

Challenges in the Multiplex Detection Immunoassay Market

Technological and Regulatory Challenges

Despite the many advantages of multiplex detection immunoassays, their widespread adoption faces some technological and regulatory hurdles. The complexity of multiplex assays—due to the need to detect multiple biomarkers simultaneously—can make assay development, standardization, and validation more challenging. Additionally, regulatory agencies, such as the U.S. FDA, must ensure that multiplex assays meet rigorous standards for accuracy and reproducibility, which can slow down their approval and market adoption.

High Initial Investment

While the long-term cost savings of multiplex assays are significant, the initial investment required for multiplex assay systems can be high. Many diagnostic laboratories, especially in emerging economies, may face financial barriers to adopting these advanced technologies. As a result, the high cost of multiplex assays could limit their use in some regions and healthcare settings.

Technical Expertise and Training

The use of multiplex assays requires specialized technical expertise for assay development, operation, and interpretation of results. Laboratories and healthcare providers need ongoing training to ensure they are able to correctly perform and interpret multiplex assays. Lack of skilled personnel in some regions may impede the broader adoption of these diagnostic tools.

The Road Ahead: Opportunities and Market Outlook

The multiplex detection immunoassay market is poised for continued growth, driven by advancements in technology, increased demand for personalized medicine, and rising chronic disease prevalence. As research into new biomarkers progresses, multiplex assays will continue to play a central role in transforming disease diagnostics and therapeutic monitoring.

Furthermore, the integration of artificial intelligence (AI) and machine learning (ML) into multiplex assay platforms holds the potential to further enhance the accuracy, sensitivity, and interpretation of results. These technologies could also enable the development of more automated, user-friendly multiplex systems, making them accessible to a broader range of healthcare providers.

As multiplex detection immunoassays become more affordable, efficient, and widely accessible, their adoption will likely expand to include not only large hospitals and research institutions but also point-of-care settings, such as physician offices and clinics. This expansion could democratize access to advanced diagnostics, improving patient care and outcomes on a global scale.

Conclusion

Multiplex detection immunoassays are redefining the landscape of medical diagnostics by offering a powerful tool for the simultaneous detection of multiple biomarkers. With applications across various disease areas, including cancer, infectious diseases, and autoimmune conditions, these assays are set to drive significant advancements in patient care, treatment monitoring, and drug development.

Despite facing challenges such as regulatory hurdles, high costs, and the need for technical expertise, the opportunities presented by multiplex detection immunoassays are vast. As technological advancements continue to improve the capabilities of these assays, the market is expected to expand rapidly, ushering in a new era of diagnostic precision and personalized healthcare.

#healthcare

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scienceblogs · 2 months ago

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🧬 MicroRNAs: Revolutionizing Early Diagnosis in Neurodegenerative Diseases

By Hafiz Muhammad Husnain Azam Researcher, Brandenburg University of Technology Cottbus-Senftenberg 📘 Published 🔗 Read Full Review on Frontiers

The Neurodegenerative Crisis: A Call for Precision Diagnostics

As the global population ages, the incidence of neurodegenerative diseases (NDs)—such as Alzheimer’s, Parkinson’s, ALS, MS, and Huntington’s—is projected to rise sharply. Yet early diagnosis remains elusive, often occurring only after irreversible neuronal damage has already taken hold.

In our newly published review, we explore microRNAs (miRNAs) as next-generation diagnostic tools—unlocking their power to detect neurodegenerative diseases early, non-invasively, and with molecular precision.

What Makes MicroRNAs Game-Changers?

MiRNAs are small, non-coding RNA molecules that regulate gene expression at the post-transcriptional level, acting as master switches for cellular behavior. Their dysregulation is intimately linked to key neurodegenerative processes including:

Protein aggregation (e.g., amyloid-beta, tau, alpha-synuclein)

Neuroinflammation and oxidative stress

Synaptic plasticity and neuronal survival

Post-translational modifications (PTMs) such as ubiquitination and phosphorylation

Key Highlights from the Review:

🔬 Pathway Regulation MiRNAs are involved in modulating tau and amyloid-beta synthesis, dopamine signaling, and neuroimmune responses—making them sensitive indicators of early neurodegenerative change.

🧠 Aging & Disease Progression Aging alters miRNA profiles in the brain, impacting neurogenesis, synaptic function, and protein homeostasis—factors critical in both healthy aging and disease onset.

🧪 PTMs and Protein Homeostasis We examine how miRNAs affect proteins central to the ubiquitin-proteasome system, a key pathway in preventing toxic protein accumulation.

💉 Non-Invasive Biomarkers MiRNAs are detectable in blood, CSF, and saliva, allowing for minimally invasive diagnostics that can detect NDs before clinical symptoms appear.

📈 Clinical Applications & Limitations We review key candidate miRNAs (e.g., miR-34a, miR-146a, miR-132) and discuss the current challenges in standardization, sensitivity, and specificity in clinical practice.

Why It Matters

MiRNA-based diagnostics could redefine the clinical approach to neurodegenerative diseases—enabling earlier interventions, better patient stratification, and personalized treatment strategies. This marks a pivotal step toward precision neurology.

Next Steps: Translating Research into Clinical Reality

Our review calls for:

Standardized miRNA panels for clinical testing

Advanced detection technologies (e.g., NGS, qPCR, microarrays)

Cross-disciplinary collaborations to move from lab to clinic

📖 Explore the full article: Frontiers in Molecular Neuroscience 🔗 Nature Shortlink: go.nature.com/3FSQrke

https://doi.org/10.3389/fnmol.2024.1386735

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healthcare-updates-with-sns · 3 months ago

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Proteomics Market: Regional Analysis and Forecast 2024-2032

The proteomics market was valued at USD 26.28 billion in 2023 and is expected to reach USD 73.87 billion by 2031, growing at a compound annual growth rate (CAGR) of 13.9% over the forecast period. This surge reflects the increasing importance of proteomics in personalized healthcare, drug discovery, and biomarker identification, as well as major advancements in mass spectrometry, chromatography, and protein microarrays.

Market Overview

Proteomics—the large-scale study of proteins and their functions—has become a cornerstone of biomedical and pharmaceutical research. As the demand for precision medicine continues to rise, proteomics is playing a critical role in understanding disease mechanisms, identifying therapeutic targets, and developing effective treatment strategies.

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Regional Analysis

North America remains the dominant market, driven by strong investments in R&D, widespread adoption of advanced proteomic technologies, and a robust healthcare infrastructure.

Europe follows closely, supported by government-funded research and increasing collaborations between academic institutions and biotech firms.

Asia-Pacific is poised for the fastest growth, thanks to expanding biotech industries, improving healthcare systems, and a growing focus on genomics and proteomics in countries like China, India, and Japan.

Market Segmentation

By Component

Instruments

Reagents

Software & Services

By Technology

Microarray

X-ray Crystallography

Spectroscopy

Chromatography

Electrophoresis

Surface Plasmon Resonance

By Application

Clinical Diagnostics

Drug Discovery

Other Applications

By End User

Hospitals

Clinical Laboratories

Pharmaceutical Companies

Academic Research Institutions

Key Players

The major key players are

Thermo Fisher Scientific – Orbitrap Fusion Lumos Mass Spectrometer

Agilent Technologies – SureScan Dx Microarray System

Waters Corporation – Xevo TQ-S Micro Mass Spectrometer

PerkinElmer – AxION iQT Mass Spectrometer

Bio-Rad Laboratories – ChemiDoc Imaging System

Abcam – Proteomics Antibody Array

GE Healthcare Life Sciences – IN Cell Analyzer 2200

Danaher Corporation – Cytiva Proteomics Solutions

Bruker Corporation – Ultraflex III MALDI-TOF Mass Spectrometer

Qiagen – QIAseq Targeted RNA Panels

Merck KGaA – Milli-Q Advantage A10

Promega Corporation – Madonna Mass Spectrometry Kit

Illumina – NextSeq 2000 Sequencing System

Sartorius AG – Octet Red96e System

Shimadzu Corporation – Nexera X2 UPLC System

Agilent Technologies – 5960 Series GC-Mass Spectrometer

Sysmex Corporation – XN-3100 Automated Hematology Analyzer

Pacific Biosciences – Sequel IIe System for long-read sequencing

Roche Diagnostics – Cobas 4800 System for PCR-based diagnostics

Becton, Dickinson and Company – BD FACSymphony S6 Flow Cytometer

Key Market Highlights

Rapid growth in precision medicine and biomarker discovery is accelerating proteomics research and adoption.

Advances in mass spectrometry and bioinformatics tools are improving protein analysis capabilities.

Increasing incidence of chronic diseases is driving the need for targeted diagnostics and treatments.

Rising government and private investments are boosting R&D funding in proteomics.

Integration of AI and machine learning in proteomic data analysis is opening new frontiers in drug development.

Future Scope

The future of the proteomics market is deeply intertwined with the evolution of personalized medicine. As researchers gain a better understanding of the human proteome, new opportunities for targeted therapies, early disease detection, and individualized treatment plans are expected to emerge. Moreover, the convergence of proteomics with AI, next-generation sequencing, and systems biology will likely create a more integrated and efficient approach to medical science, redefining how diseases are diagnosed and treated in the years ahead.

Conclusion

The proteomics market is on a strong growth trajectory, propelled by innovations in technology, increasing healthcare needs, and the growing adoption of personalized treatment approaches. With robust regional development, rising investments, and expanding applications in diagnostics and drug discovery, the global proteomics market is set to transform modern medicine and redefine the future of healthcare.

Other Related Reports:

Cell Viability Assay Market

Medical Power Supply Market

Post Traumatic Stress Disorder Treatment Market

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#Proteomics Market #Proteomics Market Share #Proteomics Market Trends #Proteomics Market Size #Proteomics Market Growth

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meditechinsight01 · 3 months ago

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Cell Analyzer Market Seeing Rapid 8% CAGR Growth, Powered by Tech and Innovation by 2030

The global cell analyzer market is projected to grow at a CAGR of 8% from 2025 to 2030, driven by the rising prevalence of infectious and chronic diseases, advancements in cell analysis technologies, and increasing adoption of automation in research and clinical applications.

Cell analyzers, which include systems like flow cytometers, cell imaging systems, and automated counters, are crucial in analyzing cell characteristics for applications such as drug discovery, immunology, oncology, and regenerative medicine. The market’s growth is supported by advancements in hardware, software integration, and growing investments in life sciences research.

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Rising Demand for Single-Cell Analysis and High-Throughput Screening Driving Market Growth

The increasing focus on precision medicine and single-cell biology has significantly boosted the demand for cell analyzers. Single-cell analysis is vital in studying cellular heterogeneity and immune responses in areas such as oncology and immunology. Additionally, high-throughput screening is becoming a cornerstone of drug discovery, enabling faster and more cost-effective testing. Cell analyzers are also critical in clinical diagnostics for monitoring immune deficiencies, hematological malignancies, and infections. The rapid development of immunotherapy solutions, particularly immune checkpoint inhibitors and T-cell therapies, has driven the need for immune-monitoring tools, further solidifying the importance of cell analyzers. In regenerative medicine, these tools are indispensable in stem cell research and related applications.

Technological Advancements Driving Innovation in Cell Analyzers

Technological progress has been a significant growth driver for the cell analyzer market. Microfluidics-based platforms are facilitating precise single-cell isolation and analysis, while next-generation flow cytometers now provide higher throughput and multicolor detection capabilities for complex samples. The integration of artificial intelligence in imaging and data analysis is automating workflows, improving data interpretation, and enabling predictive insights. Additionally, the adoption of portable cell analyzers is addressing the growing need for decentralized testing and point-of-care applications. These innovations have transformed cell analyzers into essential tools for clinical and research purposes.

Competitive Landscape Analysis

The cell analyzer market is highly competitive, with major players such as Becton Dickinson, Thermo Fisher Scientific, Danaher, Agilent Technologies, and Sysmex Corporation leading the industry. These companies are focusing on product innovation, strategic collaborations, and research and development investments to enhance their market position.

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Global Cell Analyzers Market Segmentation

This report by Medi-Tech Insights provides the size of the global cell analyzers market at the regional- and country-level from 2023 to 2030. The report further segments the market based on technique, application, and end user.

Market Size & Forecast (2023-2030), By Technique, USD Billion

Flow Cytometry

High-Content Screening (HCS)

Microscopy

Spectrophotometry

Polymerase Chain Rection (PCR)

Cell Microarrays

Others

Market Size & Forecast (2023-2030), By Application, USD Billion

Immunology

Oncology

Drug Discovery

Stem Cell Research

Others

Market Size & Forecast (2023-2030), By End User, USD Billion

Hospitals and Clinical Testing Laboratories

Pharma and Biotech Companies

Academic and Research Institutes

Others

Market Size & Forecast (2023-2030), By Region, USD Billion

North America

Canada

Europe

Germany

France

Italy

Spain

Rest of Europe

Asia Pacific

China

India

Japan

Rest of Asia Pacific

Latin America

Middle East & Africa

About Medi-Tech Insights

Medi-Tech Insights is a healthcare-focused business research & insights firm. Our clients include Fortune 500 companies, blue-chip investors & hyper-growth start-ups. We have completed 100+ projects in Digital Health, Healthcare IT, Medical Technology, Medical Devices & Pharma Services in the areas of market assessments, due diligence, competitive intelligence, market sizing and forecasting, pricing analysis & go-to-market strategy. Our methodology includes rigorous secondary research combined with deep-dive interviews with industry-leading CXO, VPs, and key demand/supply side decision-makers.

Contact:

Ruta Halde Associate, Medi-Tech Insights +32 498 86 80 79 [email protected]

#Cell Analyzer Market

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walkingghotst · 3 months ago

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North America Genomics Market Growth and Recent Trends by Forecast 2027

The North America Genomics market is expected to reach US$ 20,348.43 million in 2027 from US$ 7,669.34 million in 2019. The market is estimated to grow with a CAGR of 13.3% from 2020-2027.

NORTH AMERICA GENOMICS MARKET SEGMENTATION

North America Genomics Market: By Technology

Sequencing

Microarray

Polymerase Chain Reaction

Nucleic Acid Extraction and Purification

Others

North America Genomics Market: By Product and Services

Instruments/Systems

Consumables

Services

North America Genomics Market:By Application

Diagnostics

Drug Discovery and Development

Precision/Personalized Medicine

Agriculture & Animal Research

Others

North America Genomics Market: By End User

Research Centers

Hospitals & Clinics

Biotechnology & Pharmaceutical Companies

Others

North America Genomics Market: By Country

North America

Canada

Mexico

North America Genomics Market: Company Profiles

Illumina, Inc.

Danaher

F. HOFFMANN-LA ROCHE LTD.

BIO-RAD LABORATORIES INC.

General Electric Company

THERMO FISHER SCIENTIFIC INC.

Agilent Technologies, Inc.

Eurofins Scientific

QIAGEN

BGI

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North America Genomics Report Scope

Report Attribute Details

Market size in 2019 US$ 7,669.34 Million

Market Size by 2027 US$ 20,348.43 Million

Global CAGR (2020 - 2027) 13.3%

Historical Data 2017-2018

Forecast period 2020-2027

Gaining a Competitive Edge: North America Genomics

Strategic insights for the North America Genomics market deliver a data-informed examination of the industry's configuration, encompassing current trends, major players, and regional specificities. These insights furnish actionable recommendations, empowering readers to gain a competitive advantage by pinpointing unexploited market niches or formulating distinctive value propositions. By leveraging data analytics, these insights assist industry participants – including investors and manufacturers – in foreseeing market shifts. A future-oriented perspective is paramount, enabling stakeholders to anticipate upcoming market evolutions and strategically position themselves for enduring success within this dynamic North American arena. Ultimately, incisive strategic intelligence equips readers to make well-considered decisions that boost profitability and achieve their commercial goals within the genomics landscape.

Localized Market Understanding: North America Genomics

Comprehending the geographic scope of the North American Genomics market is vital for business operations and competitive standing. Recognizing local variations, such as differing consumer inclinations (e.g., preferences for specific genomic services or data privacy protocols), shifting economic landscapes, and diverse regulatory frameworks, is essential for tailoring strategies for particular markets. Businesses can broaden their market penetration by identifying under-served areas or modifying their offerings to align with local needs. A defined market focus allows for more efficient deployment of resources, precisely targeted marketing initiatives, and enhanced positioning relative to regional competitors, ultimately stimulating expansion within these specific geographic areas.

Historic Data: 2017-2018 | Base Year: 2019 | Forecast Period: 2020-2027

Analysis By Technology (Sequencing, Microarray, Polymerase chain reaction (PCR), Nucleic Acid Extraction and Purification, and Others), Product & Service (Instruments/Systems, Consumables, and Services), Application (Diagnostics, Drug Discovery and Development, Precision/Personalized Medicine, Agriculture & Animal Research, and Others), End User (Research Centers, Hospitals and Clinics, Pharmaceutical & Biotechnology Companies, and Others), and Country

About Us:

Business Market Insights is a market research platform that provides subscription service for industry and company reports. Our research team has extensive professional expertise in domains such as Electronics & Semiconductor; Aerospace & Defense; Automotive & Transportation; Energy & Power; Healthcare; Manufacturing & Construction; Food & Beverages; Chemicals & Materials; and Technology, Media, & Telecommunications

#North America Genomics Market #North America Genomics Market Segmentation #North America Genomics Market Overview

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biotechscientist · 3 months ago

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Transcriptomics is the branch of molecular biology that focuses on the study of RNA transcripts produced by the genome under specific conditions. It provides insights into gene expression patterns, regulatory mechanisms, and cellular responses at a given time.

Key Techniques in Transcriptomics

RNA Sequencing (RNA-Seq) – A high-throughput method to analyze the complete transcriptome using next-generation sequencing (NGS).

Microarrays – A hybridization-based method that detects specific RNA sequences using complementary probes.

qRT-PCR (Quantitative Reverse Transcription PCR) – Used for precise quantification of specific mRNA levels.

Northern Blotting – A traditional method to detect specific RNA molecules.

Single-cell RNA-Seq (scRNA-Seq) – Studies transcriptomics at a single-cell resolution, helping to understand cellular heterogeneity.

Applications of Transcriptomics

Disease Biomarker Discovery – Identifying gene expression changes in diseases like cancer, diabetes, and neurodegenerative disorders.

Drug Development – Assessing how drugs influence gene expression at the cellular level.

Precision Medicine – Personalized treatment strategies based on an individual's transcriptomic profile.

Systems Biology – Understanding how genes interact in biological networks.

Functional Genomics – Linking transcriptome data with gene function and phenotype.

Challenges in Transcriptomics

Data Complexity – Large datasets require advanced bioinformatics tools for analysis.

RNA Stability – RNA is more prone to degradation than DNA, requiring careful handling.

High Cost – RNA-Seq, especially at single-cell resolution, remains expensive.

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market-insider · 3 months ago

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Digital Pathology and Big Data: Unlocking the Future of Diagnostics

The global digital pathology market size is expected to reach USD 1.73 billion by 2030, registering a CAGR of 8.0% from 2024 to 2030, according to a new report by Grand View Research, Inc. The market is anticipated to witness exponential growth owing to rising prevalence of chronic diseases aided by increasing demand for accurate diagnostics. Chronic diseases affect nearly one in every three adults. Whereas, according to the CDC, in the U.S., approximately, 51.8% of adults have at least one chronic disease. Digital pathology, including molecular tissue profiling, biobanking, tissue microarray analysis, and molecular biology, plays an important role in the drug development pipeline and companion diagnostics. Growing demand for high-quality tissue samples in tissue-based biomarker research is expected to drive technology adoption over the forecast period.

Digital Pathology Market Report Highlights

Based on product, The device segment held the largest share of 51.72% in 2023 and is anticipated to grow at a lucrative growth rate during the projected period. The device segment includes a slide management system and scanner. The segment growth is attributed to the increasing adoption of digital pathology in academic research activities with enhanced resolution

Based on application, Disease diagnosis is anticipated to witness the fastest growth rate from 2024 to 2030 due to an increasing prevalence of chronic diseases and demand for noble diagnosis techniques

In terms of end-use, The hospitals segment dominated the market in 2023 with a share of 36.7% due to the growing incorporation of digital pathologies in healthcare settings for efficient disease diagnosis

North America dominated overall market in 2023 with a share of 40.7%, due to the presence of well-established digital infrastructure and several technological advancements pertaining to the incorporation of technology in healthcare settings

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Increasing adoption of telepathology with the launch of newer versions of the technology, such as in June 2022, Tribun Health launched TeleSlide Patho 5, an online telepathology platform used for providing clinical and timely expertise to patients. Moreover, the market is expected to see intense competition in the near future as companies adopt more stringent strategies to compete. Moreover, technological advancements, such as the digitization of pathology lab makes the specialty more efficient, the specimen more reproducible, and pathologists' work easier. In past few years, several breakthrough advancements have provided a significant boost to market growth.

For instance, in September 2021, Paige received FDA approval for Paige Prostate, an AI solution for the detection of prostate cancer. The product is the first AI-enabled pathology product to gain marketing authorization. This was further followed by the collaboration of F. Hoffmann-La Roche Ltd. with Ibex in October 2021 for the development of artificial intelligence-based pathology applications for the improvement of patient care. Furthermore, major players are adopting strategies like collaborations and partnerships with a focus on technological advancements, such as robotic light microscopy, digital imaging, multiple fiber optic communications, and computerization, to enhance the adoption of digital pathology.

For instance, in December 2022, Deciphex launched Patholytix 3.0, a Digital Research Pathology Platform with an aim to revolutionize tools available for research pathologists and designed to overcome the limits of LIMS software that allows users to effectively manage associated data and samples. Furthermore, with the launch, the company also highlighted features of the new platform that impact workflow and offer simpler and more expedient report creation.

List of Key Players in the Digital Pathology Market

Leica Biosystems Nussloch GmbH (Danaher)

Hamamatsu Photonics, Inc.

Koninklijke Philips N.V.

Olympus Corporation

F. Hoffmann-La Roche Ltd.

Mikroscan Technologies, Inc.

Inspirata, Inc.

Epredia (3DHISTECH Ltd.)

Visiopharm A/S

Huron Technologies International Inc.

We have segmented the global digital pathology market based on product, type, application, end-use, and region

#DigitalPathology #PathologyMarket #MarketResearch #HealthcareTrends #MedicalInnovation #HealthTech #MedTech #AIinHealthcare #HealthcareIndustry #AIinPathology #Telepathology #MachineLearning #DeepLearning #DigitalDiagnostics #SmartHealthcare #PrecisionMedicine #Biotech #MedicalAI

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researchyblog · 4 months ago

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North America Tissue Diagnostics Market: Growth, Trends, and Key Insights

Market Overview

The Tissue Diagnostics involves analyzing tissue samples to diagnose diseases, determine the nature of tissues (cancerous or non-cancerous), and understand the characteristics of observed cancers. The process utilizes various instruments, including slide staining systems, slide scanners, tissue processing systems, embedding systems, and tissue microarrays. The North American tissue diagnostics market is driven by the rising prevalence of cancer, increasing healthcare expenditure, advanced diagnostic infrastructure, and robust government initiatives supporting cancer research and screening programs. Furthermore, a growing inclination toward personalized healthcare, heightened awareness of early disease diagnosis, and the adoption of digital pathology and automation are anticipated to present significant growth opportunities.

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Rising Cancer Prevalence Driving Market Growth

Cancer is a leading cause of death in North America, contributing to a significant healthcare burden. The American Cancer Society reported approximately 608,570 cancer-related deaths in the U.S. in 2021. Common cancers among men include prostate, lung, and colorectal cancers, while breast and colorectal cancers are prevalent among women. Factors such as unhealthy diets, tobacco and alcohol use, sedentary lifestyles, exposure to carcinogens, obesity, and pollution contribute to the rising cancer incidence.

Lung cancer, the second most common cancer in both men and women, exemplifies this trend. According to GLOBOCAN, around 253,537 new lung cancer cases were diagnosed in 2020 in the U.S., with projections estimating this figure could reach 352,415 by 2040. Cancer risk increases with age due to declining bodily functions and immunity, with most lung cancer diagnoses occurring in individuals aged 65 and older.

Early cancer detection and precise tumor characterization are crucial for improving survival rates and enhancing quality of life. Effective early detection not only reduces mortality but also lowers treatment costs. As cancer prevalence continues to rise, the demand for advanced tissue diagnostics solutions in North America is expected to grow significantly.

Government Initiatives and Cancer Screening Programs

Government and organizational initiatives play a crucial role in promoting cancer screening and early diagnosis. Screening tests help identify cancer before symptoms appear, which is vital for reducing mortality through timely treatment. The American Cancer Society (ACS) has established guidelines and recommendations for cancer screening to facilitate early detection.

In 2021, ACS launched the ‘Get Screened’ campaign to encourage regular cancer screenings. The COVID-19 pandemic had interrupted many screening programs, but the ‘Get Screened’ initiative aimed to reinvigorate these efforts by highlighting the importance of routine screenings. PatientPoint, a patient engagement platform, also launched a campaign to promote the initiative across nearly 100,000 healthcare providers in over 25,000 offices nationwide. Such programs help boost awareness and drive demand for tissue diagnostics tools and technologies.

Key Market Segments and Growth Projections

1. Product Type: Consumables to Lead the Market

The tissue diagnostics market is categorized into consumables and instruments. In 2025, the consumables segment is expected to hold the largest market share. The recurring demand for consumables, ongoing research to develop novel reagents, and the frequent use of antibodies, assays, and kits for detecting infectious diseases contribute to this growth. The diverse availability of reagents and the increased need for COVID-19 testing products further support this segment's expansion.

2. Technique: Immunohistochemistry (IHC) at the Forefront

Immunohistochemistry (IHC) is anticipated to dominate the market among the various techniques, including in-situ hybridization, digital pathology, molecular diagnostics, and traditional staining methods. IHC's popularity is driven by its high accuracy in cancer screening, technological advancements, and favorable reimbursement policies for IHC-based tests. It is particularly preferred over conventional enzyme staining techniques because of its ability to distinguish between different tumor types effectively.

3. Application: Breast Cancer Diagnosis Holds the Largest Share

Breast cancer is the most prevalent cancer globally, contributing significantly to the tissue diagnostics market. In 2020, 281,591 women were diagnosed with breast cancer in the U.S., with estimates suggesting this number could rise to 316,632 by 2032. The high incidence rate of breast cancer necessitates advanced diagnostic tools and technologies, positioning this application segment as a leading contributor to market growth.

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4. End User: Hospitals & Diagnostic Laboratories Dominate

In 2025, hospitals and diagnostic laboratories are expected to account for the largest share of the North America tissue diagnostics market. These facilities serve as primary points for disease diagnosis and treatment, offering extensive cancer screening and diagnostic services. Factors such as a high cancer incidence rate, an aging population, the availability of screening programs, and increased awareness about cancer diagnostics are driving this segment's growth.

Regional Insights: The U.S. Leading the Market

The U.S. is projected to remain the largest market for tissue diagnostics in North America through 2025. Several factors contribute to this dominance:

High Geriatric Population: An aging population is more susceptible to cancer, driving the need for diagnostic tools.

Increasing Cancer Incidence: The growing number of cancer cases amplifies the demand for advanced diagnostics.

Government Initiatives: Robust programs and funding to promote cancer screenings enhance market opportunities.

Presence of Key Market Players: Many major companies are headquartered in the U.S., contributing to the region's strong market position.

Competitive Landscape

The North America tissue diagnostics market is highly competitive, with key players focusing on product innovation, strategic partnerships, and geographic expansions. Notable companies include:

F. Hoffmann-La Roche Ltd. (Switzerland)

Thermo Fisher Scientific Inc. (U.S.)

Abbott Laboratories (U.S.)

Danaher Corporation (U.S.)

QIAGEN N.V. (Netherlands)

Becton, Dickinson and Company (U.S.)

Agilent Technologies, Inc. (U.S.)

Merck KGaA (Germany)

Cell Signaling Technology, Inc. (U.S.)

Sakura Finetek Japan Co., Ltd. (Japan)

These companies are actively investing in research and development to enhance their product offerings and maintain competitive advantages.

Future Market Trends

Automation and Digital Pathology: Increasing adoption of digital pathology solutions and automation in diagnostics processes to enhance accuracy and efficiency.

Personalized Healthcare: Rising trend towards tailored treatment plans based on precise tissue diagnostics.

Integration of AI and Machine Learning: Improving diagnostic accuracy and streamlining workflow in laboratories.

Increased Cancer Screening Programs: Government and private sector initiatives are likely to boost demand for diagnostic tools.

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