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eva-nes-cen-ce-blog · 5 years

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Multi nutrient-rich bilberry is valuable in maintaining skin health, cardiovascular physical fitness, cognitive strength, healthy and disease-free eyes, unobstructed blood circulation and also much better functioning of the total body.

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For many decades, the anticancer possibility, antimicrobial, antioxidant and also anti-inflammatory residential or commercial properties of bilberry have been treasured for their effectiveness in a variety of problems consisting of looseness of the bowels, diabetes mellitus, liver and also kidney damages.

What is Bilberry?

Bilberry is a tiny edible dark blueberry of a low-growing shrub in the genus Vaccinium. Bilberry is scientifically referred to as Vaccinium myrtillus. It is a close family member of blueberry, blaeberry, huckleberry, whortleberry, as well as cranberry. [1] These are tasty berries are belonging to Northern Europe and also have been valued for their restorative efficiency in the standard system of European medication for many centuries.

Bilberry is a spreading, low-growing, deciduous bush with slim branches having tiny pinkish blooms and intense environment-friendly, oblong and also sharp leaves. [2] The plant returns dark purple berries gathered during summertime time as well as can be used fresh or in dried out kind. Today, they are grown in Northern Asia, Europe, and North America as well as are becoming fairly popular as a tasty active ingredient in preserves, pies, as well as jams along with for their capability to deal with a range of health problems.

Nutritional Facts

Just like its relatives, huckleberry, and also blueberry, bilberry is the wealthiest natural sources of anthocyanin, which is an antioxidant that provides it the dark blue color. [3] In addition to anthocyanin, it likewise has various other phenolic components such as quercetin, tannins, pectin, and catechins. It also has alkaloids, carbonic acids, and a series of essential nutrients consisting of vitamins A, B1, B2, C, E, and also K. The mineral treasure present in it chromium, manganese, zinc, and also iron. [4]

Wellness Conveniences of Bilberry

Below are the main manner ins which bilberries can make you healthy and balanced. Take a look at them.

Improves Vision

Bilberry serves for the upkeep of eye health and wellness. [1] Scientific studies have likewise advocated the effectiveness of bilberry remove in preventing age-related eye disorders together with other eye conditions such as cataract as well as night-blindness. [3] Leutin present in the eye, when incorporated with the compounds existing in bilberry, aids boost vision. [3] One more study carried out on bilberry has additionally suggested that its valuable enzyme-stimulating activity secures the eyes from endotoxin-induced uveitis. [5] Its removes stimulate the manufacturing of rhodopsin pigment which sustains the eye to adapt to light modifications. [2]

Treats Diarrhea

Bilberry has been used to treat tummy conditions such as looseness of the bowels, indigestion, and queasiness. [6] Its anti-inflammatory and astringent homes help to tighten up tissues and also lower the signs and symptoms of looseness of the bowels.

A white dish of fresh bilberries with leaves on a wood table

Anti-inflammatory Activity

As a result of the astringent activity of tannins and also pectin existing in bilberry, it puts in a therapeutic effect on tummy swellings. It additionally recovers inflammation caused by the mucous membranes of the throat and also mouth when applied topically. Anti-inflammatory residential properties of this fruit likewise help in curing problems like thrombosis as well as angina.

Blood Health and wellness

Research studies have confirmed the positive effects of bilberry on high blood pressure and vascular health and wellness causing the restraint of platelet gathering and also smooth muscle contraction. It assists to enhance capillaries, stimulates blood circulation and stops conditions like varicose capillaries and piles.

Persistent Venous Deficiency

Persistent venous insufficiency is a problem in which the valves in leg veins that carry blood to the heart gets harmed. [7] This leads to itching, swelling, and discomfort in the leg. It often additionally leads to skin abscess. The anthocyanosides existing in bilberry aid to reinforce the blood vessels as well as lower the signs.

Controls Diabetes

The performance of bilberry for avoiding and also treating diabetic issues has actually been appreciated since early times and has actually also been promoted by current clinical findings. It assists in managing the blood sugar level degrees in the body, as a result of the abundant concentration of anthocyanins. Research studies recommend its dietary remove helps in boosting the problem of hyperglycemia as well as insulin level of sensitivity in individuals struggling with type-2 diabetes. [8]

May Assist Protect Against Cancer

A group of researchers from the College of California Santa Barbara led by Nguyen V et al. [9] discovered that bilberry removes had an antiproliferative effect on human breast cancer cells. They avoid the proliferation of deadly cells and generate apoptosis. A relative study conducted on different berries has rendered bilberry to be the most potent in inhibition of malignant cells. [3] It additionally aids to avoid the side effects of radiation treatment.

Neuroprotective Effects

Bilberry can reduce the risk of cognitive problems such as dementia and also Alzheimer's. [10] The phenolic substances existing in the fruit eases these neurological concerns.

Menstrual Cramps

Women have actually likewise reported its effects on decreasing menstruation cramps. Bilberry remove is likewise efficient in curing ulcers as well as hindering fibrocystic bust disease.

Skin Treatment

Bilberry supports and strengthens the collagen structures, stalls bacterial development and assists in cleansing of the body. It is additionally advised by physicians prior to surgeries in order to minimize the connected bleeding later.

Antioxidant Power

The antioxidant power of bilberry makes it a beneficial multipurpose remedy. The abundant resource of anthocyanosides works water-soluble chemicals that have radical scavenging high qualities. They seek for oxygen-free radicals created during basal metabolism and also counteract their results. This protective action stops the occurrence of many problems caused as a consequence of oxidative anxiety.

Maintains Liver Health

Researchers have actually shown that the inhibitory as well as extreme scavenging task of bilberry extracts improves the level of helpful glutathione as well as vitamin C in the body as well as decreases the concentration of nitric oxide in the liver cells.

Protects Against Kidney Failing

One more antioxidant result of bilberry is its protection against kidney damage. Scientific research has actually shown that its extracts assist in normalizing several important factors consisting of degrees of creatinine, product, blood, urea, nitrogen, as well as nitric oxide. [11] It likewise assists to secrete hefty steels from the body resulting in much better detoxification.

Health and wellness advantages of bilberry - infographic

Cardioprotective Results

The heart-protective impact is attributed to the potential of anthocyanins present in bilberry, which assists in controling the LDL (poor) as well as HDL (good) cholesterol degrees in the body. [12] One more research has actually recommended that it likewise helps in protecting against multiple heart diseases such as atherosclerosis. [13]

Antimicrobial Effects

Bilberry consists of phenolic components which have actually likewise been located to apply antimicrobial activity. [3] This repressive action of the berry antagonizes numerous human virus including salmonella, H.pylori, Bacillus, Clostridium and also Staphylococcus aureus, and also avoids the advancement of involved conditions. Current scientific searchings for likewise suggest the capacity of its remove in combating antibiotic-resistant organisms.

Uses of Bilberry

Bilberry can be consumed in fresh, dried, powdered, removed, or in liquid form. When buying the extract, ensure that you purchase the ones that have 25% anthocyanin in it for good health and wellness results. There are different ways to serve the fruit such as:

Include bilberry fruit or the fallen leaves to warm water as well as serve on your own a healthy tea!

Utilize the berry as a filling for pies and also tarts.

Prepare its jams and also enjoy it with bread.

You can likewise drink some revitalizing bilberry juice. The juice is additionally used as a base for liqueur and as a flavor for sorbets and also various other treats.

If you slouch to do any one of the above, just gobble it up in its raw form! It works as a yummy snack also.

Side Effects

Although bilberry is considered risk-free for intake, there are a few exceptions [14] that demand to be considered:

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unsub13x-blog · 5 years

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Multi nutrient-rich bilberry is beneficial in preserving skin health and wellness, cardio health and fitness, cognitive strength, healthy and disease-free eyes, unblocked blood flow as well as much better functioning of the overall body.

youtube

For several decades, the anticancer potential, antimicrobial, antioxidant and anti-inflammatory residential properties of bilberry have actually been prized for their efficiency in a series of problems including diarrhea, diabetes mellitus, liver and kidney damages.

What is Bilberry?

Bilberry is a tiny edible dark blueberry of a low-growing shrub in the genus Vaccinium. Bilberry is scientifically described as Vaccinium myrtillus. It is a close relative of blueberry, blaeberry, huckleberry, whortleberry, and cranberry. [1] These are delicious berries are native to Northern Europe and also have actually been valued for their restorative effectiveness in the conventional system of European medication for many centuries.

Bilberry is a spreading, low-growing, deciduous shrub with slender branches having tiny pinkish blooms and also brilliant green, oblong as well as sharp leaves. [2] The plant yields dark purple berries harvested during summer time and can be utilized fresh or in dried form. Today, they are grown in Northern Asia, Europe, as well as North America and are becoming fairly prominent as a delicious active ingredient in preserves, pies, as well as jams along with for their capability to deal with a range of health conditions.

Nutritional Details

Much like its cousins, huckleberry, and blueberry, bilberry is the richest natural resources of anthocyanin, which is an antioxidant that supplies it the dark blue shade. [3] Along with anthocyanin, it additionally contains other phenolic elements such as quercetin, tannins, pectin, as well as catechins. It likewise consists of alkaloids, carbonic acids, and also a range of vital nutrients including vitamins A, B1, B2, C, E, and also K. The mineral treasure existing in it chromium, manganese, zinc, as well as iron. [4]

Wellness Advantages of Bilberry

Below are the major manner ins which bilberries can make you healthy and balanced. Take a look at them.

Improves Vision

Bilberry serves for the maintenance of eye health and wellness. [1] Scientific research studies have additionally promoted the efficiency of bilberry remove in stopping age-related eye conditions along with other eye conditions such as cataract and also night-blindness. [3] Leutin present in the eye, when combined with the compounds present in bilberry, assists improve vision. [3] An additional research study performed on bilberry has also recommended that its beneficial enzyme-stimulating task secures the eyes from endotoxin-induced uveitis. [5] Its removes boost the production of rhodopsin pigment which supports the eye to adapt to light adjustments. [2]

Deals with Looseness of the bowels

Bilberry has actually been utilized to deal with stomach conditions such as looseness of the bowels, indigestion, as well as nausea. [6] Its anti-inflammatory as well as astringent residential properties help to tighten up tissues and also decrease the symptoms of diarrhea.

A white dish of fresh bilberries with fallen leaves on a wooden table

Anti-inflammatory Action

Due to the astringent action of tannins and pectin present in bilberry, it puts in a therapeutic effect on tummy inflammations. It additionally recovers swelling caused by the mucous membrane layers of the throat as well as mouth when applied topically. Anti-inflammatory residential or commercial properties of this fruit likewise help in healing problems like apoplexy and angina.

Blood Health and wellness

Research studies have actually confirmed the favorable results of bilberry on blood pressure and vascular health leading to the inhibition of platelet gathering as well as smooth muscle contraction. It helps to enhance blood vessels, stimulates circulation as well as stops problems like varicose blood vessels and also hemorrhoids.

Chronic Venous Lack

Persistent venous insufficiency is a problem in which the valves in leg veins that lug blood to the heart gets harmed. [7] This causes itching, swelling, and pain in the leg. It often also leads to skin abscess. The anthocyanosides existing in bilberry assistance to enhance the capillary and lower the symptoms.

Controls Diabetic issues

The effectiveness of bilberry for protecting against and curing diabetes mellitus has actually been valued considering that very early times and also has also been supported by recent scientific searchings for. It aids in regulating the blood sugar level degrees in the body, due to the abundant focus of anthocyanins. Researches recommend its dietary remove aids in boosting the problem of hyperglycemia and insulin sensitivity in individuals struggling with type-2 diabetic issues. [8]

May Assist Prevent Cancer Cells

A team of scientists from the College of California Santa Barbara led by Nguyen V et al. [9] located that bilberry essences had an antiproliferative impact on human bust cancer cells. They avoid the expansion of deadly cells and induce apoptosis. A comparative study performed on various berries has actually rendered bilberry to be one of the most potent in restraint of malignant cells. [3] It likewise helps to avoid the negative effects of radiation treatment.

Neuroprotective Results

Bilberry can lower the danger of cognitive concerns such as mental deterioration and Alzheimer's. [10] The phenolic substances present in the fruit minimizes these neurological problems.

Menstrual Pains

Females have actually additionally reported its effects on lowering menstrual cramps. Bilberry extract is additionally effective in healing abscess and preventing fibrocystic breast disease.

Skin Treatment

Bilberry supports and also strengthens the collagen structures, stalls bacterial development and helps in detoxing of the body. It is additionally advised by doctors before surgical procedures in order to reduce the linked blood loss later.

Antioxidant Power

The antioxidant power of bilberry makes it a beneficial multipurpose remedy. The rich source of anthocyanosides serves water-soluble chemicals that possess radical scavenging high qualities. They choose for oxygen-free radicals created during basal metabolism and neutralize their effects. This protective activity stops the event of several issues triggered therefore of oxidative anxiety.

Preserves Liver Health And Wellness

Scientists have shown that the repressive and also extreme scavenging task of bilberry essences boosts the degree of valuable glutathione and vitamin C in the body and minimizes the concentration of nitric oxide in the liver cells.

Stops Kidney Failing

An additional antioxidant result of bilberry is its defense versus kidney damage. Scientific study has actually revealed that its essences help in normalizing numerous essential factors including levels of creatinine, product, blood, urea, nitrogen, and nitric oxide. [11] It additionally assists to secrete hefty metals from the body resulting in much better cleansing.

Wellness benefits of bilberry - infographic

Cardioprotective Effects

The heart-protective impact is credited to the potential of anthocyanins present in bilberry, which helps in managing the LDL (poor) and also HDL (good) cholesterol degrees in the body. [12] One more research study has actually recommended that it likewise helps in stopping several heart diseases such as atherosclerosis. [13]

Antimicrobial Impacts

Bilberry consists of phenolic elements which have also been located to put in antimicrobial task. [3] This inhibitory action of the berry antagonizes different human virus consisting of salmonella, H.pylori, Bacillus, Clostridium as well as Staphylococcus aureus, and protects against the development of affiliated conditions. Recent scientific findings also suggest the possibility of its essence in combating antibiotic-resistant microorganisms.

Uses of Bilberry

Bilberry can be consumed in fresh, dried, powdered, drawn out, or in fluid form. When acquiring the extract, make sure that you get the ones that have 25% anthocyanin in it permanently wellness results. There are various means to serve the fruit such as:

Add bilberry fruit or the fallen leaves to hot water and also offer on your own a healthy tea!

Use the berry as a filling up for pies and tarts.

Prepare its jams as well as relish it with bread.

You can likewise consume alcohol some revitalizing bilberry juice. The juice is likewise used as a base for liqueur and as a flavoring for sorbets and also other treats.

If you are lazy to do any one of the above, just swallow it up in its raw type! It acts as a tasty snack too.

Negative effects

Although bilberry is thought about risk-free for intake, there are a few exceptions [14] that need to be considered:

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ayurvedickidneycare · 3 years

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Preventing Lupus Nephritis With Ayurvedic Treatment

The human body is a remarkably well-oiled instrument that has evolved from different body shapes, characteristics and has also gained a strong core cognitive ability to make the best use of tools for survival in different surroundings. The human body also possesses a natural defense mechanism against the disease that tries to invade and impair various processes of your body, which are important to keep you alive.

This natural defense is termed the "Immune system" that protects you against the effect of several diseases, such as bacteria, viruses, fungi, and toxins. Your immune system is the army of your body that ensures to keep you safe from the effects of certain diseases that mainly occur when your body is exposed to certain environments and other biological stresses.

What if the army attacks their own civilians?

This would cause extreme mayhem across the nations and lead to many innocent people's lives at stake. This is what precisely occurs when your immune system, which is the defense army of your body, mistakenly misfires by producing a protein called antibodies that charges your own tissues, and organs, especially your kidneys. This condition is termed lupus nephritis that can seriously harm your kidneys and prevents them from filtering out waste and other excessive substances from the body.

When To Seek Medical Attention?

You're required to consult the doctor if you're feeling any of the following symptoms addressed above in your health. Autoimmune diseases can be prevented with routine medications or require dietary modifications to get your health back on track.

What are the symptoms of lupus nephritis?

Lupus nephritis primarily affects the kidneys' functioning that takes decades to get visible. However, when is advanced with time, symptoms may include the following-

Blood in urine

High blood pressure

Swollen hands, feet, or ankles

High creatinine levels in your blood

Loss of appetite

Pain in the lower back

Feeling pressure or pain on the chest

Muscle cramps and twitches, especially at night

How Does Lupus Nephritis Affect Your Kidney Functioning?

Lupus antibodies can damage your kidneys by causing inflammation in blood tubules and tissues around your kidneys, leading to a permanent loss of your kidneys' functioning. This condition gives a spike to the levels of waste products inside your bloodstream and develops some serious health conditions, such as high blood pressure, stroke, brain tumor, and irreversible kidney damage.

What Causes Lupus Nephritis?

A person born with autoimmune disease is likely to have a family history of lupus nephritis. Exposure to certain environments can trigger this disease in people who have inherited this problem from their parents' cells. However, we have addressed three potential triggers include the following-

Exposure to sunlight- Sunlight can trigger lupus in people inherited with a predisposition for lupus.

Having certain infections- Developing certain infections can trigger lupus and cause serious health issues in some people.

Increased consumption of certain medicines- If you're under medications, for example- medicines to control blood pressure, anti-seizure, and antibiotics can trigger lupus. Some medicines can reduce the effect of lupus, but there are always chances of the problem recur in your body later in life. For a permanent recovery, switch to lupus nephritis ayurvedic treatment

Is There Any Permanent Cure?

Ayurvedic medicines for lupus nephritis are proven effective in curing this problem of scratch. The lupus nephritis ayurvedic treatment involves a strong association of natural remedies, diet, and exercise that together prevent the progression of the disease naturally without leaving any side effect on the body. Unlike several various modern medications, Ayurvedic treatment never prevents the primary symptoms of the problems. The herbs used in the Ayurvedic treatment detect and cure the primary drivers of the problem and ensure permanent relief from the problem.

Lupus nephritis mainly affects your kidneys' by causing inflammation inside the blood tubules that supply blood to your kidneys. Ayurvedic treatment for lupus nephritis works effectively to cure swelling and inflammation occurring inside your kidneys and enhance the kidneys' blood supply. It’s always advised to consult only certified Ayurvedic practitioners in order to get the right guidance and personal recommendations to cure this problem. If you’re looking for the one then Kidney and Ayurveda is the name you can count on.

#health & fitness #health #kidney problems #lupus nephritis

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jasonosims34 · 3 years

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Survival Myth Busted Drinking Your Own Urine

Generally, normal urine constitutes approximately ninety-five percent water and five percent waste products, including ammonia, urea, creatinine, pigmented blood products, and inorganic products. There is a belief that drinking urine comes with benefits, though these have not yet been scientifically proven.

Therefore, this article talks more about how the assumptions of consuming your urine in a survival situation can be essential, the potential health risks it might cause, and how one can purify urine using reverse osmosis or distillation. Let’s have a look at each of them independently. You will love to follow Ready and Armed if you are interested in more topics like this one.

The Belief that Drinking Your Urine Would be Beneficial in a Survival Situation

The belief that drinking urine is associated with some benefits dates back to the early nineties where it was believed that urine could whiten teeth and cleanse mouths. Similarly, others also thought that urine was a perfect medicine for various conditions.

However, recent health advocates have claimed that some of the benefits associated with drinking urine include improving eyesight, supporting thyroid health, healing wounds in the mouth, boosting the immune system, and replacing lost nutrients.

Additionally, others also use urine as an emergency source of water. For instance, one might end up drinking their urine when they do not have access to any other water source after a natural disaster or a shipwreck.

Other components found in your urine, like small quantities of vitamins, hormones, and antibodies, also play a vital role in improving your health. Urine is also believed to be a potent diuretic that can make your body release more water and salt.

Although some people typically use diuretics to lower blood pressure, it is believed the safer way to do so is by consuming urine. However, it is important to note that no research has proven drinking urine can improve your health and lower blood pressure.

Some of the Potential Health Risks of Drinking Urine

Even though there are some associated benefits of drinking your urine, it can also cause some harm to your body, especially if you are healthy and lack any underlying condition. However, people at a higher risk of being affected by the contaminants found in urine are people with chronic diseases and children.

Consuming urine can present some serious health risks. We have listed those risks below:

Infection

Typically, urine is not sterile or pure because as it leaves the kidneys, it usually passes through the urethra and goes into contact with your skin as it leaves the body. Similarly, your urine also contains bacteria, irrespective of if you are healthy or not.

That is why drinking urine might expose you to various diseases. Despite urine containing antibodies, it also has bacteria present, including antibiotic-resistant strains-pseudomonas, staphylococcus, salmonella, E. coli, and shigella.

While bacteria might not cause an infection to all people who consume urine, it can certainly increase the risk of diseases. Those with weak immune systems are especially at risk.

Dehydration

Urine is a diuretic that increases your risk of dehydration when consumed because the salts in it reduce the amount of usable water in your body. Even though some people consume urine because they have nothing else left to drink, there is no evidence to suggest that one would survive when doing so since dehydration could still get the best of them. For this reason, most experts do not recommend drinking your urine, even if there is no clean water, because of the waste and salts excreted in the urine.

Electrolyte imbalances

Drinking urine causes some electrolyte imbalances because it contains other electrolytes and salts. Typically, if one is dehydrated and consumes large amounts of urine, they have dangerous electrolyte imbalances.

Other risks

Other risks associated with drinking urine include:

Exposure to dangerous chemicals, for example, traces of medications

Irritation

Burning of wounds in the throat or mouth

Delayed medical treatment, especially when one believes that urine can treat that particular ailment.

How to Purify Urine Through Reverse Osmosis or Distillation

Most people think that filtering urine will leave them with just water because urine contains both water and waste products. However, it is not true because urine is made up of dissolved ions, salts, and molecules of urea that can pass through the filter. Similarly, other forms like chemical or UV light treatment only kill microbes but do not eliminate the molecular-sized substances found in urine.

Therefore, the only way to safely drink your urine in a survival situation when there is no other water source is by removing the dissolved contaminants or lowering their concentration. Unfortunately, you can only do so using two ways, which are reverse osmosis and distillation.

In reverse osmosis, high pressure is used to force water through a thin membrane that only allows water molecules and not even salt to penetrate. Distillation typically involves evaporating your urine to let out water molecules and allow them to cool and condense in a different drinking vessel.

Even though these two methods usually enable you to isolate drinkable water, it is also tough to isolate every trace of the contaminant’s smell and taste. In addition, the water obtained after the two processes might not benefit your body because essential nutrients like calcium and phosphorus are not present.

In summary, it is essential to note that drinking urine does not help improve your health or lower blood pressure but might even worsen your health. Therefore, if you are seeking some natural remedies on the matter, you are encouraged to consult a healthcare professional who is knowledgeable on the subject.

Similarly, when your access to water is scarce, it is essential to seek a healthier source like clean rainwater, water in food, condensation, or fruits and vegetables. It is not recommended to consume your urine because it has several unwanted effects, including dehydration, which can worsen and intensify any underlying condition, and other unwanted effects, including the increase of skin infections and electrolyte imbalances.

Since there are no proven benefits of consuming urine, it is vital to consider the possible benefits and side effects of this practice before putting your health at risk.

from https://readyandarmed.net/survival-myth-busted-drinking-your-own-urine/

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naturalhealthbeautycare · 4 years

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How To Lower Creatinine Levels Naturally | How To Reverse Kidney Disease

How to improve Kidney Function. How to treat kidney disease naturally How To Lower Creatinine Levels in Kidney How To Lower Creatinine Levels in blood

Click here to know more: How To Reverse Kidney Disease Naturally: The Lost Book Of Remedies: Natural Health Beauty

#kidneydisease #healkidneydisease #curekidneydisease #treatkidneydisease #Reversekidneydisease

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monika0101 · 3 years

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Creatinine levels can be lowered with the help of Ayurvedic treatment along with home remedies. They both are natural ways of lowering creatinine levels without causing any adverse effects on the body.

#health #health care #kidney disease #kidney problems #creatinine

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romandavis-blog · 3 years

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The waste product that is found in the blood and urine of a person is known as creatinine. If you want to know how well your kidney is working, you should do the creatinine clearance test. The symptoms of high level are drug toxicity, kidney infection, diabetes, high blood pressure and heart disease etc. Under normal circumstances, your body can

#ways to lower creatinine level #Creatinine LowerLevel

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advanceayurveda24 · 3 years

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Home Remedies to Naturally Lower Your Creatinine Levels

Creatinine is a byproduct that is produced when you utilize your muscles. Eating bunches of protein may likewise create modest quantities of this natural compound.

Your circulation system transports creatinine to your kidneys, where your body sift it through your pee. In any case, if your kidneys aren't working appropriately, the degree of creatinine in your blood can develop.

Your medical services supplier may check your blood and pee for creatinine, just as request different tests to assess the soundness of your kidneys. A typical level relies upon your age, race, sex, and body size.

Anomalous creatinine levels might be an indication of kidney illness.

You may require a creatinine test on the off chance that you have these indications:

changes in pee (recurrence, torment, frothiness, or blood)

muscle cramps

weakness

queasiness or retching

puffiness around the eyes

growing in the feet or lower legs

Your primary care physician may moreover suggest normal creatinine testing on the off chance that you have any of the accompanying conditions, which may add to diminished kidney work:

diabetes

hypertension

thyroid infection

immune system infections

bacterial contamination of the kidneys

an obstructed urinary lot

a family background of kidney infection

Creatinine levels can likewise rise incidentally from exhausting activity or utilizing certain meds like .

Besides, getting pregnant or eating an eating routine high in red meat may contribute.

Your body needs to clean your blood to work ideally. The most ideal approach to bring down your creatinine levels is to treat the basic reason.

On the off chance that your blood creatinine is high, it's essential to work with your medical care supplier to build up a therapy intend to address any clinical issues that may be hurting your kidney work.

Alongside your medications and different medicines, find out if the accompanying way of life changes are suitable for you.

Here are different ways to normally bring down your creatinine levels.

1. Try not to take supplements containing creatine

Creatine is a characteristic compound made in your liver. It's moved to your muscles where it's utilized for energy. Unused creatine that is not utilized as energy gets changed over into creatinine, a side-effect.

Notwithstanding its normal structure, creatine is accessible as an oral enhancement. A few competitors utilize these creatinine-delivering enhancements to help improve athletic execution.

Anybody wishing to decrease their creatinine levels to improve their kidney capacity ought not take creatine supplements. There's restricted exploration on creatine supplements and their general well being.

Talk with your primary care physician prior to adding any enhancement to your eating regimen.

2. Diminish your protein admission

Exploration shows that eating a lot of protein can increment creatinine levels Trusted Source, in any event briefly. Specifically, cooked red meat can influence creatinine. The warmth from cooking causes the creatine found in meat to deliver creatinine.

Individuals following eating regimens high in red meat or other protein sources, including dairy items, may have higher creatinine levels than individuals who eat less of those nourishment.

On the off chance that you eat loads of red meat, change to more vegetable-based dishes. Take a stab at trading out hamburger burgers for:

vegetable patties

good vegetable stew

lentil soup

3. Eat more fiber

More exploration is expected to decide dietary fiber's impacts on creatinine levels. All things considered, one investigation indicated critical decreases in creatinine levels in individuals with persistent kidney sickness who expanded their fiber admission.

Fiber can be found in numerous nourishment's, including:

organic products

vegetables

entire grains

vegetables

4. Lower your salt admission

Diets that incorporate abundance salt can add to hypertension. Prepared nourishment, specifically, are regularly stacked with sodium and phosphorus, which studies Trusted Source have demonstrated possibly cause renal issues.

Think about zeroing in on entire, natural nourishment's, and utilizing flavors and spices to enhance your food whenever the situation allows.

5. Try not to smoke

Smoking cigarettes can hurt the body in various manners, including essentially increasing Trusted Source the danger of persistent kidney infection.

Stopping can be an approach to diminish the probability of issues with your kidneys that may increment creatinine levels.

6. Cutoff your liquor consumption

Liquor utilization can be a precarious issue with regards to kidney work. A few examinations have demonstrated that moderate Trusted Source liquor utilization may help decline the danger of constant kidney infection.

Other studies Trusted Source have demonstrated that inordinate liquor can possibly harm the kidneys. It can likewise contribute Trusted Source to conditions like hypertension and liquor reliance.

On the off chance that you drink liquor, counsel your medical care supplier about the most secure levels for your well being needs.

Note: Ayurveda helps How to reduce creatinine There are also several treatments in world but best option is our old Ayurveda in other words 1st treatments by ayurvedic kidney failure treatment, ayurveda benefits it have no side effects, its help to cure diseases Naturally.

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allenmendezsr · 4 years

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Stage 3 Reduced to Stage 2 Kidney Disease…

“I followed the diet and took the herbal remedies and I reversed the severity of my kidney disease from a stage 3 to a 2!

I am thrilled with my results! I will continue to take the natural herbal treatments and do the diet to help improve my kidney function even more in the coming weeks. My life is changing for the better. I am so happy to say my renal doctor says my kidney disease is reversing!”

– Gladys Martinez – FL, U.S.A.

Kidney Health Improved With Simple Diet Changes!

I Only Used The Diet And 1 supplement And Still Got Good Results…

“I wonder if I can improve my kidney health even further.

I know because of my good results I will certainly keep using the suggested diet and supplement with this natural treatment program.

In fact, I couldn’t afford the other products and just stuck to the diet and the one supplement and still got improvement in kidney function.”

– Davin Blake

Helped Hypertensive Kidneys!

Unlike Any Other Books On Kidney Disease…

“This program is unlike any other books on kidney disease that I have read.

I learned so much I feel like an expert on how to improve and heal my kidneys with natural remedies from the inside of my body out!

These techniques and the diet have helped improve my kidney function very quickly. It even helped reverse the severity of my hypertensive kidney disease damage.“

– Marie – United Kingdom

Kidney Numbers Improved!

I Was Skeptical But I Had Nothing To Lose…

“I couldn’t just sit around and do nothing like my doctors suggested.

They didn’t want me to do anything or to take herbs or herbal remedies, but I had to try something – they just wanted me to do dialysis!

This program allowed me to take control of my health. I went from Stage 4 to Stage 3 kidney disease.

It was easy to do and my BUN, creatinine and anemia are all in better ranges.”

– Mary Hall – Alameda, CA

This Program Is So Powerful It Has Been Doctor Reviewed & Approved …

“What I Turn To for My Chronic Kidney Disease Patients… I Highly Recommend This!”

“After speaking to Robert and looking into the references I know recommend this program to anyone with kidney disease. The patients I have given this program to are doing well, with improvements in their symptoms and kidney disease states.”

Dr. Knox D.C. – Chiropractic Doctor (Canada)

Wondering what this incredible ‘kidney restoration program’ is?

Just read on to find out more. But first you need to know this…

SHOCKING KIDNEY HEALTH NEWS UPDATE!

People don’t know they have kidney problems until their kidney disease is stage 3 or 4 with kidney damage so severe they end up on dialysis for life!

1 in every 5 people during their first year on dialysis in the U.S. will DIE!

Individuals with CKD are 16 to 40 times more likely to die with kidney failure from complications such as a heart attack or stroke.

Kidney disease affects 4 in every 10 people over age 65.

Can you prevent worsening kidney problems and avoid dialysis with the condition your kidneys are in now?

Dear Kidney Disease Sufferer,

Hi, my name is Robert Galarowicz.

I suffered with stage 5 kidney disease and

my kidneys failed me!

I was lucky enough and young enough to get a kidney transplant.

But now I have to deal with transplant anti-rejection drugs and having a higher risk of not only that my kidney may be rejected by my body — but HIGHER RISK OF DIABETES AND EVEN… CANCER!

So I KNOW from horrible past experiences with my own kidney failure what you could suffer — if you don’t do something to reverse your problems with kidney disease right now!

Here’s what happened to me…

I Was Only 22 When My Doctor Told Me… Your Kidneys Are Killing You!

I suffered with a constant FOG in my brain … along with moodiness, fatigue, swelling, headaches, depression and loss of appetite.

My health got worse as time when on . . . so I went to get checked out. I still remember the look on the nurse’s face when she took my blood pressure . . .

Total shock and confusion as my blood pressure reading came back at staggeringly high 190/110!

I was just 22 and my doctor was afraid I was going to drop dead of a heart attack.The doctor ordered some tests and the results showed there was something “Wrong” with my kidneys. Not diabetes, not some other specific disease. Just something “wrong.”

I’ll never forget the moment the doctor looked me in the eye after doing my biopsy and told me…

“Robert, You Have Only 10 Years To Live. . .”

Everything came crashing down around me. All my plans to start a career, meet the woman of my dreams and marry and have kids — vanished before my eyes!

Over the next two months my doctors pumped me full of Prednisone and Cyclosporine – drugs that were supposed to help stop my kidney failure. . . But all it did was give me awful acne and make it impossible to sleep . . . I was soon overwhelmed with mood swings, terrible depression and psychosis that put me in the hospital.

That’s when they told me my kidneys were close to failing!

I needed to get ready for dialysis and that’s when the put the fistula in my arm. (the photo to the right ==>

The fistula is a surgical connection between a vein and an artery that makes a big enough vein for the huge dialysis needles.

I remember waking up from surgery, seeing the 9 inch scar on my arm and just breaking down crying. The worst part was the doctors still had no idea what I had or why my kidney’s were failing. They just call it “unknown glomerulonephritis” . . .

Eventually I start showing more loss of kidney function . . .My kidney health continues to worsen and this goes on for 2 years until . . .

I Had TOTAL Kidney Failure . . .

It was Horrible… I vomited every day for 3 months straight, with paralyzing fatigue, suicidal depression, and bad swelling in my legs.

I had no social life, because not many girls want to date or be around a sick guy… “who will end up on dialysis.”

Things got worse, when I ended up in the hospital almost in a renal failure induced coma. And that’s the first time they hooked me up to the machine . . .

3 days a week, three to four hours a day they puncture my arm with two oversized two-inch long needles and “clean my blood.”

What you might not know about…

DIALYSIS . . . is ONCE you start it It’s For The Rest Of Your Life . . .

Or until you get a kidney transplant (If you are lucky enough to get a kidney transplant.)

I Felt Like A Prisoner Chained To That Damn Machine!

Excruciating pain from the needles and the cramping . . .

Feeling wiped out all the time from the dialysis.

Not to mention the blood clots, pulling too much water out of your body or the 100 little things that can go wrong every time you go in.

The worst part was the loneliness…

I remember when the dialysis nurse put the needle in my arm for the first time. I thought about how it was the first time in two years a woman had touched me.

For two and a half years my life revolved around dialysis. I wake up every day feeling awful and hoping with everything I would get a kidney transplant.

Then I get lucky . . . I get a call from Miami saying they have a ‘cadaver’ kidney for me . . .

I hop a plane feeling so excited. Feeling like I can finally say goodbye to that machine and get my life back. But the new kidney fails right away. I spend 14 days in the hospital when it was supposed to be only 4 days. The surgery is horrible!

Complications keep coming up and I start to think I made a BIG mistake. That I would have been better off staying on dialysis.

Even when my new kidney stabilizes I still have to deal with the rotten side effects of the anti-rejection drugs I’m on: acid reflux, frequent colds, joint pain, depression and feelings of anxiety.

Why Am I Telling YOU All This?

Even now, 9 years after my transplant I’m scared of becoming a statistic and dying from complications due to kidney failure.

The truth is: the average kidney from a cadaver lasts just 7 years and one from a live donor last maybe 15. I know now that I didn’t HAVE to suffer the way I did!

If you get a new donor kidney…

YOU MUST TAKE ANTI-REJECTION DRUGS AND YOU NEED TO BE SCREENED FOR CANCER REGULARLY.

*** The ANTI-REJECTION DRUGS CAN CAUSE HIGH BLOOD PRESSURE, HIGH CHOLESTEROL AND INCREASE YOUR RISK FOR DIABETES AND CANCER!***

I want to save you the terrible pain, the heartache, depression and the intense suffering I endured. I want to show you how to Improve your kidney health and avoid the horrors of dialysis treatments!

You CAN have Healthy Kidneys’… and live an active, healthy life where you never even THINK about your kidneys – IF YOU KNOW THE RIGHT THINGS TO DO!

But before I get into all of that, I want to tell you the truth.

I Was SCARED… I’d End Up Right Back On that Damn Dialysis Machine!

After I recovered from my kidney transplant surgery and adjusted to the anti-rejection meds I was forced to be on, I tried to get my life back together. I knew I had to find out the real truth about why my kidneys failed. I started studying everything I could about kidney disease . . .

The truth is it was because I was SCARED . . . scared that if I didn’t do SOMETHING I’d end up right back on that damn machine . . . And as I got deeper and deeper into the truth about why kidney’s fail and learned more about what causes kidney disease and harms kidney function… I got really pissed off!

I’d suffered needlessly for so many years!

NOW. . . I know now the ‘real truth’ . . . that my kidney disease was treatable!

You can improve your kidney health — WITHOUT needing or suffering through dialysis!

100% All Natural Treatments & Remedies Scientifically PROVEN To REPAIR Kidney Damage

UNKNOWN to Doctors!

“The Shocking Truth”

About Kidney Disease!

Here are just a few of the ‘WORST Kidney Treatment Problems’ I STUMBLED upon during my years of kidney research and training into the REAL causes (and real solutions) for Kidney Disease . . .

KIDNEY TREATMENT PROBLEM # 1:

The common marker used to detect kidney function (BUN and creatinine) is NOT considered reliable and may NOT increase above normal ranges — until 60% of total kidney function is lost.

(I’ve discovered there are better tests for kidney disease that are covered by your insurance that your doctor may not even know about. Find out what they are!)

KIDNEY TREATMENT PROBLEM # 2:

Heavy metal poisoning can send your kidneys into the toxic over load leading to damage and loss of your kidney’s function — but the horrible fact is not 1 in 1000 doctors will check for this!

(But it is critical you get tested for this if you got a kidney problem and I’ll tell you all about it and why and what to do about it.)

KIDNEY TREATMENT PROBLEM # 3:

By avoiding one commonly eaten food you can delay kidney failure and dialysis by up to 3 years – and most medical doctors won’t tell you about what food to avoid!

(I’ve created a list of common foods to avoid and tell you the truth about why those harmful foods are doing damage to your kidneys.)

KIDNEY TREATMENT PROBLEM # 4:

Common everyday over the counter household items you use in your house you need to get rid off which harm your natural kidney function — that medical doctor’s don’t know about!

(I’ll reveal what these kidney-damaging products are that you could be taking into your body on a daily basis which are sure to affect you and will worsen your kidney health.)

KIDNEY TREATMENT PROBLEM # 5:

One of the most popular weight loss diets on the market can burn your kidneys out — and your doctor probably suggested you lose weight with this exact same low carb/high protein diet!

(This is criminal! Because using popular weight loss diets to try to control your weight – can be causing your kidney function to get even worse! Find out what is the ‘right diet’ to use to avoid putting more stress on your kidneys and still lose weight!)

KIDNEY TREATMENT PROBLEM # 6:

Do you love your coffee, caffeine and soda? Did your doctor warn you about the added health risks of drinking them and how they do irreparable damage to your kidneys?

(Find out how by drinking certain types of herbal teas you can help the filtering system of the kidneys and even naturally restore your kidney’s health!)

KIDNEY TREATMENT PROBLEM # 7:

Do you feel constantly over-tired, know you are not sleeping well and end up tossing and turning during the night? Then when you tell your doctor about your insomnia they prescribe a habit forming sleeping pill — with lots of nasty side effects!

(Instead, find out how one supplement can end your fatigue and speed up your energy at a cellular level and quickly restore your feeling of well being.)

KIDNEY TREATMENT PROBLEM # 8:

Did you know there are many all natural nutrients including herbs, herbal remedies and amino acids that can improve your energy, delay kidney disease and allow you to live a better quality of life that are recommended by the National Kidney Foundation? But there are no doctors following these recommendations or testing for the nutrients in their patients suffering with kidney disease!

(I found over 10 over the counter supplements with proven research that can drastically improve your kidney function. But don’t go running out to the health food store asking the cashier for advice. There are many herbs, herbal remedies and nutritional supplement products out there that can actually make your kidney disease or chronic kidney disease(ckd) worse.

Instead I’ll tell you all about the 100% all natural treatments and remedies used in Europe, Asia and other countries which have successfully treated and reversed kidney disease for over 30 years!)

KIDNEY TREATMENT PROBLEM # 9:

Did you know that there’s ALREADY a safe scientifically validated over the counter supplement that can stop many kidney diseases in its tracts? It’s criminal that in January of 2009, the FDA classified this potent, entirely safe Chronic Kidney Disease(ckd) therapeutic as a drug, putting it out of reach for many Americans suffering from this deadly condition!

(I’ll tell you all about this and why in other countries this 100% safe all natural supplement has been proven to work and is a staple of most kidney treatment plans!)

KIDNEY TREATMENT PROBLEM # 10:

No one should be forced to bear the outrageous burden of costly pharmaceuticals and their toxic side effects when a perfectly safe natural alternative treatment exists. This drug won’t be available to Kidney Disease suffers for another 10 to 15 years. Why? Because it has to pass FDA approval and that may take many years for enough clinical trials to prove it works – even though it has been saving kidneys in other countries around the world for years!

(Luckily there is the cousin of this supplement that proves to have the same effects still available to the public and is used in other countries with phenomenal success and you can learn about it.)

Introducing…

The “Kidney Saver” eBook Program That Medical Dialysis Promoters hope you’ll never discover…

The “No Dialysis Needed” All Natural Kidney Health And Kidney Function Restoration Program . . .

My “No Dialysis Needed” program is a step-by-step treatment program which helps improve your kidneys naturally, without the use of unnatural man-made pharmaceutical drugs.

Even better, when you follow the program you’ll be able to delay dialysis by years or even decades . . . or possibly even avoid dialysis all together!

You CAN Improve Your Kidney Function Using 100% ALL NATURAL Remedies & Treatments . . .

Heal Your Kidneys

Without Dialysis . . .

Without Drugs . . .

Without Side Effects!

But NO MEDICAL DOCTOR In Western Medicine Was Taught This Information In Medical School!

Medical Doctors are pushing their patients towards dialysis and transplants when some didn’t need to. But as a nephrologist (kidney specialist) once told me, “that’s the American way of treating kidney disease.”

It’s not doctors who are at fault. They’re taught in medical school how to treat kidney disease, chronic kidney disease(ckd) and they stick to the book but also those who teach doctors to treat kidney problems!

You need to know that these alternative ‘KIDNEY TREATMENT SECRETS’ ARE REAL and most medical doctors in the United States DON’T KNOW!

My program is specifically designed to IMPROVE Kidney Health NATURALLY and ELIMINATE the need for dialysis completely.

Don’t Just “Manage” Your Kidney Disease…

Reverse It!

If you’ve been shocked by your doctor with this grave news:

“There is nothing you can do, you have to wait for your kidneys to fail, go on dialysis and hopefully be eligible for a kidney transplant.”

Now you have ALTERNATIVE OPTIONS!

The All Natural Kidney Health & Kidney Function Restoration Program™ is a compilation of the best and most effective natural treatments for kidney disease from around the world. It is meant as a complement to your allopathic, conventional or standard medical care, not a replacement.

You have a right to know all the real facts about your kidney disease and I’m blowing the lid off what doctor’s don’t know!

When you have this easy to understand kidney health program in your hands you can make better informed decisions about what’s ‘the right thing to do’ to support your kidney function and return your body’s kidneys to natural wellness!

See, these days I’m known as an expert on kidney disease . . . I help people who suffer from this horrible disease heal their kidneys, regain kidney function by reversing stages!

You may even be able to postpone or avoid dialysis or a transplant forever (just read the rest of this letter and I’ll show you how!) But what not many people (except my clients and my close friends) know is my own personal struggle and battle with kidney disease . . .

That’s what made me so passionate about helping you reverse your kidney disease. And why I will do anything to help you avoid being chained and imprisoned by that horrible machine!

In my ‘all natural kidney restoration program’ I’ve put all of my passion into my work to help people just like you — avoid worsening kidney health and the horrors of dialysis. . .

And The Incredible Kidney Restoration Results I Got For My Clients And Customers Were So Astonishing They. . .

SHOCKED Their DOCTOR!

It’s true! Allow me to read to you only a few of the amazing kidney restoration success stories I’ve had with my clients here in my New Jersey office and customers of my program . . .

Just read these improved kidney health success stories…

Creatinine From 2.7 to 1.8, GFR From 24 to 44, And Potassium Back In A Normal Range

“Thank you so VERY much!

I was really worried I was going to lose my husband. Mark had high blood pressure that caused a lot of kidney damage. We saw a dietitian that gave us some useful information, but I really was looking for something more. When I came upon your program I was excited to get started. I purchased your program, and went out and got all the foods and supplements for the kidneys you recommended to start giving to Mark.

My husband started to feel more energy and in about 6 weeks he said he felt about 15 years younger! His nephrologist was happy at the positive results. We explained to him about the program, and he said to keep doing what he was doing. Your diet and herbal treatment program is working to reverse his kidney problems.

It has been 10 months and Mark’s kidney health has stabilized. Your program explains and covers every aspect of how to improve kidney function and makes perfect sense that even a housewife, like myself, understands.”

~ Mark & Barbara Henswourth Lowell, Massachusetts

No More Protein In My Urine And Inflammation Is Gone

“Living on a small farm I wasn’t sure I would be able to follow your treatment program. I felt very relieved that you provided the exact products, supplements and internet stores to get them from. This made it very easy for me. I was able to modify my diet like you recommended and was happy to find I had most of the food already on my farm.

I had IgA Nephropathy kidney disease for years but was okay until recently. My doctor said I had a lot of protein in my urine and inflammation. I took medications like prednisone which helped but nowhere near enough and the side effects were really bad.

Your program really made sense to me. I followed it and took all the anti-inflammatory supplements. Overall it was fairly easy to follow with all the references you provided. On my 3 month follow up the doctor said I had normal amounts of protein in the urine and the inflammation was better. He lowered my prednisone which was a big relief for me. I still maintain everything and glad god lead me to your program.

By the way your kidney diet is easy to follow and eating out guide is very helpful, especially when I visit my family in the city.”

~ James Anderson Harrison County, West Virginia

Diabetic Kidney Disease Reversed In 3 Months

“I was very scared of when the doctor told me my kidneys were damaged. I followed the program exactly for a diabetic.

My 3 month follow up showed I had normal kidney function! I can’t thank you enough”

~ Christy Cambridge United Kingdom

Robert, Here Is My Blood Work I Said I Would Send If Your Program Worked…

Creatinine From 3.2 to 2.0, GFR 16 to 39(More Than Doubled), Potassium, Cholesterol & Albumin All Normal.

I thank you from the bottom of my heart. You have no idea how much this means to me and my family.”

~ Eliazar Brooklyn, New York

Kidney Function From 19 To 41%, Phosphorus Normal, No More Itching And Sleeping Better

“Hi Robert, when I was diagnosed with renal disease I didn’t believe what the doctors were telling me. For the first time in my life I was scared of the future and didn’t know what to expect. I have a family and kids to care for and I need to work to provide for them. The way the doctors were talking it was like I would have no life in the near future.

I was reassured I could avoid renal failure when I found The All Natural Kidney Health Program. It covered so many areas including how to improve kidney function and renal diet to follow. I followed the program and what I really noticed was how much better I was sleeping and the constant itching had gone away.

On my next doctor’s appointment I had a good feeling things would be better. I found my phosphorus mineral level was normal and I gained back 22% renal function. The doctors and myself think I will be able to avoid dialysis and renal failure.

Thank you from the bottom of my heart.”

~ Khalifa Al Reshedi Jiddah, Saudi Arabia

Doubtful Anything Could Help But Glad I Was Wrong

“Stumbled across this video searching for anything that would help. Robert knew exactly what I was going through and I ordered his program.

Fascinating material that has improved my kidneys. So grateful I found this website.”

~ Abbey Walker Perth, Australia

Learn How To Improve Your Kidney Function With The “No Dialysis Needed” All Natural Kidney Function Restoration Program!

Exactly what kidney friendly healing foods to eat and which toxic kidney destroying foods to avoid in easy to follow lists. You will be shocked at what you learn…

Find out the ‘little known secrets’ about how to heal your kidneys like …

The “must have” insurance covered tests that most medical doctors don’t know about or don’t use … results of these tests can have you on your way to more energy, better mood and better kidney health. . .

Find out the name of the delicious natural sweetener used for 20 years in Japan and Brazil to treat kidney disease, high blood pressure and diabetes. . .

Discover which cooking methods and 3 herbal teas prevent kidney cell damage and kidney disease complications. . .

Did you know blueberries have powerful healing antioxidants that reverses kidney cell damage?

The 4 healing oils to use in your cooking, and one of these powerful oils stops kidney damage from toxins. . .

The kidney restoring diet is super simple to follow. No measuring food, keeping track of nutrients, or any other annoying meal planning tasks. . .

Supplements are essential to improve your kidney health but not all supplements are created equally … The one must AVOID ingredient in MANY supplements and even in some prescription vitamins and minerals that is detrimental to your kidney health. . .

The “Core Supplement Program” … covers the exact supplements, what they are, how they improve your kidneys, dosages to use, and 100% Safe FDA approved with third party tested companies and exact products. . .

The common grocery store item which instantly strengthens your kidneys against any disease. . .

The “weird” herb which is a prescription in China that stops kidney disease right away, available over the counter in the U.S.. . .

The family of good bacteria which starts to do the WORK of the kidneys when it’s not functioning properly, this allows your kidneys to rest and recover . . .

The “caterpillar fungus” which makes a highly effective kidney healing mushroom herb used by Asian doctors. . .

The fiber that sweeps away kidney damaging toxins popular in Middle Eastern medicine for treating any kidney disease or chronic kidney disease. . .

Human studies show a special Indian herbal remedy from a flowering plant reverses kidney disease caused by diabetes. . .

The prescription kidney cell protecting supplement available over the counter which a doctor will never prescribe and find out what your doctor doesn’t know. . .

The naturally occurring human hormone that restores the kidneys “antioxidant defense system and fixes sleep problems“… which is part of the reason why you have kidney disease. . .

Kidney Disease makes your bones brittle, weak and easily break … The 3 Wonder Nutrients which have shown to play a vital role in the production of building strong bones and how regular calcium is NOT what you need to take!

Uncover how to gain control of diabetes and blood pressure which will bring your kidney disease to a grinding halt. . .

How To Read A Food Label and know what you are eating … this is your ultimate reference to understanding quantities and nutrients in food. . .

Dialysis and kidney transplants: What you can use from the All Natural Kidney Health & Kidney Function Restoration Program to live a good quality of life and how to keep your transplant kidney healthy so it can last you the rest of your life. . .

The common over the counter, prescription medications and drugs which you want to steer clear of at all cost. I guarantee you will be mad no one told you these before. . .

And many more incredible kidney health boosting methods than I can list here…

The All Natural Kidney Health & Kidney Function Restoration Program has zero filler and is fully backed by modern day scientific research. In fact, there are over 300 medical citations with majority from peer reviewed medical journals “the gold standard” in medicine and the same exact, very expensive, books they use in medical schools. . .

But first you may the wondering. . .

Are These Natural Kidney Remedies And Supplements 100% Safe?

Everything in this program is safe, natural and with good safety profiles, proven case studies and doctor recommended. Many of the products including the diet, supplements and herbs have been used safely in other countries for years and in hospitals in the United States.

If you are concerned about any of the products in the program, discuss them with your local naturopath, nutritionist or physician, or email me and I will help you make an informed decision before taking any products you are concerned about. See my contact information at the bottom of this page.

“Even Medical Doctor’s Approve It!”

“My Patient Is Doing Better Than I Could Have Imagined…”

“I’ve been impressed by how well researched and complete this program is.

This 100% all natural kidney restoration program takes into account the factors of kidney disease and gives you many options and information to help your kidneys return to their natural good health. As a medical doctor I look at the risks and benefits of all treatments and especially alternative treatments before making a recommendation, that said, this program definitely gets my thumbs up.

It presents well-researched, scientifically balanced information with diet and dozens of natural, drug-free ideas and remedies you can start using to improve the health of your kidneys today. My patient began this program and had excellent results, better than I could have imagined. Everyone with any type of Kidney Disease and chronic kidney disease(ckd) needs this program. “

Dr. John Ree – Medical Doctor (U.S.A)

I want to give you as much possible help as I can and be absolutely certain that you get every possible tool and strategy to overcome kidney disease and avoid dialysis and a transplant.

So When You Get Started TODAY, For A Limited Time I’ll Also Throw In 5 Super Bonuses …

My Kidney Health & Restoration Guide Is “Enhanced” With 5 More Customized Kidney Health & Wellness Guides!

PLUS!

MY PERSONAL EMAIL CONTACT!

I don’t just want you to slow or stop your kidney disease … I want you to improve your kidney function – quickly and with a minimum of fuss!

So for a limited time, when you order The “No Dialysis Needed” All Natural Kidney Health & Kidney Function Restoration Program, I’ll also include the 5 kidney health boosting bonuses, designed to help you quickly heal and return your kidney function to more normal levels.

Your Special Bonus # 1 is…

“The All Natural Kidney Health & Kidney Function Restoration Program Diet Plan”

You get a 14-day easy-to-follow menu plan with recipes and snacks. . . No fussing over putting together your own breakfast, lunch and dinner. . . no worries about what you’re going to eat next and simple, quick meal plans to prepare with no trips to special grocery stores.

Each day contains breakfast, lunch and dinner with 1 to 2 optional snacks. All nutritionally balanced to reduce stress on the kidneys, control mineral imbalances and maximize your healing. It also includes a section on making your own meals and how to adjust recipes to make them kidney friendly.

One of the toughest things about living with kidney disease is eating out with friends and family.

Just follow the “Tips for Eating Out Section” which covers all major restaurants where you will be able to make a kidney friendly choice enjoying your meal and the company.

Value: $39.95 yours FREE

Your Special Bonus # 2 is…

“The Definitive Guide To Potassium Content Of Foods” Over 1,000 Foods Listed

Potassium is a key nutrient needed for your heart and muscles to work properly and is regulated by your kidneys. When your kidneys are not healthy your potassium may increase to dangerous levels leading to further decline in kidney function and possibly a heart attack. .

The Definitive Guide To Potassium Content of Foods will give you the knowledge to select the right foods to make the perfect low potassium food choices to help your kidneys heal.

With over 1,000 foods listed there is no way you can’t find the potassium content of any food you want to know the potassium content of.

Value: $19.95 – Yours FREE!

Your Special Bonus # 3 is…

“The Definitive Guide To Protein Content Of Foods” Over 1,000 Foods Listed

Regulating your protein intake is crucial to improving your kidneys. This guide gives you the information to know how much protein is contained in foods educating you to make the right choices for a lifetime of better kidney health…

Protein foods contain high amounts of the mineral called phosphorus. Phosphorus is used for building bones, teeth, and is found and used by every cell in the human body. In kidney disease and chronic kidney disease(ckd) phosphorus may build up to toxic levels.

By regulating your protein consumption you can control your phosphorus from reaching dangerous levels. This takes the stress off the kidneys to maximize your kidney healing.

So, the “The Definitive Guide To Protein Content Of Foods” also controls your phosphorus levels allowing for the best kidney health you can imagine. Two very important uses out of one guide!

Value: $19.95 – Yours FREE!

Your Special Bonus # 4 is…

“The Kidney Diet Grocery Shopping List”

Sample Grocery Shopping List … as simple as printing it out and bringing it with you to the store. No need to dig through pages and take notes on what to buy. It’s all packaged into one convenient easy to follow list and it is printable so you can take it with you when you do your grocery shopping!

Value: $19.95 – Yours FREE!

Your Special Bonus # 5 is…

“The Kidney Diet Tracking Sheets”

Kidney Diet Tracking Sheets. You get diet tracking sheets you can easily print and this allows you to keep track of what you eat to help you stay on track and allows you to more easily stick to a better kidney health diet with a minimum of fuss. These Kidney Diet Tracking Sheets allow you to make a smooth easy transition to a healthier kidney diet.

Value: $19.95 – Yours FREE!

And when you order today…

For A Limited Time One Last Super Bonus!

60 Days Of Unlimited Email Support Provided After Your Purchase!

The “No Dialysis Needed” All Natural Kidney Health & Kidney Function Restoration Program offers Exclusive Personal One-On-One Counseling. You get FREE professional private email counseling, advice and guidance from a certified nutritionist, naturopath, kidney disease sufferer.

When you order the program today you get email access to a life-long medical researcher who is always just an email away. If in any time you feel confused, you can have your questions privately answered.

This advice is practically priceless.

You’ll always feel that someone is there for you…so you’re never left to deal with your kidney disease and chronic kidney disease(ckd) alone. With this free and unlimited email support you can feel good that you are always on track, you are always encouraged, and… you’ll be able to complete the program more effectively and get quicker and greater results to heal your kidneys.

I’d love to hear from you after you order the program. You’ll receive my private email with your order. I promise you’ll get an answer in 24 hours.

Value: $197 – Yours FREE!

“This Sounds Amazing, Robert, But How Much Does It Cost?”

“How much is it worth to you to have a PROVEN method at your disposal to help you truly IMPROVE your kidney health?

If you’ve suffered from Diabetes or Kidney Disease for any length of time, you already know how expensive it is and how much you are suffering right now.

Even with insurance (and insurance is covering less and less these days) you can end up paying THOUSANDS of dollars per year for blood tests, treatments and drugs that have nasty side effects and do as much harm as good.

Not to mention the cost of dialysis itself which can run up to $150,000 a year. . .

The price of the complete “No Dialysis Needed” program is extremely affordable. . .even for people on a fixed income. I made it so affordable most anyone can get it to help them reverse their kidney disease right in the comfort of their own home!

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ayurvedickidneycare · 3 years

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Can High Creatinine Levels Kill You?

Looking good doesn't necessarily mean that you're in good health…

You might be looking perfectly fit and healthy from the outside, but you never know when a common cold or fever will turn into a chronic illness, such as coronavirus, sinus, and dengue which takes intensive medical care and diet your health back on track. Chronic illnesses often camouflage themselves with a runny nose, chills, or mild headaches that we try to suppress by consuming certain medicines, such as painkillers, aspirin, or antibiotics, that only prevent the symptoms but do not cure them permanently.

This is precisely what happens when you're diagnosed with chronic kidney disease. Chronic kidney disease is a serious health condition that can easily go unnoticed at the initial stages and suddenly charges on your health when the problem gets severe with time.

But our body is precisely designed to survive and readily respond to various environmental and biological stresses. Muscle pain, fever, lower back pain, or not feeling hungry are some of your body's ways of saying that you should seek medical attention so that you can eliminate the disease at its initial stage before it gets worse with time.

High creatinine level has become the commonest chronic health condition that tells that your kidneys are not working properly. Read this article until the end; if you're not familiar with the term "creatinine", what are the consequences, causes, and symptoms of high creatinine levels that come with it.

What is Creatinine?

Creatinine is a chemical waste produced during muscle breakdown or during the wearing and tearing of muscles. Everyone has creatinine in their blood that usually gets filtered by their kidneys via urine. The creatinine level varies from person to person based on sex, race, diet, and the number of physical activities performed in a day.

What is The Meaning of High Creatinine?

Studies have shown that the average level of creatinine in a human body should be around 0.84 MG/DL to 1.21 MG/DL; if your lab report shows creatinine level beyond this range, then it indicates kidney dysfunction, which means that your kidneys are not working properly as they should.

How Can We Detect High Creatinine Problems in Time?

High creatinine level can be a primary symptom of chronic kidney disease, which is progressive in a certain period and only gets visible when it gets severe over time. Hence, it's recommended to keep getting your urine and blood sample tested every year.

Doing this will help you to monitor your kidneys' health and lets you detect the threat in time before it starts interfering with your kidneys' functioning. However, you may feel some physical complications in your health which include the following:-

Nausea and vomiting

Feeling pain or pressure on the chest

Fatigue

Having high blood pressure

Swelling in legs, ankles, feet, and hands

Itchy and dry skin

Having frequent urges to pass urine

Kidney cleansing remedies to reduce high creatinine level

A high creatinine level doesn't necessarily mean that your kidneys are not working properly; certain environmental factors can give a spike to your creatinine level for a shorter period of time. Here we've listed some To lifestyle changes that can anchor your high creatinine level back to its normal stage, includes the following-

Avoid supplements containing creatine

Creatine is an important chemical compound produced by your liver to power your body to perform internal and external body functioning. But, now it's also available as an oral supplement and widely used by many athletes and bodybuilders to enhance their performance. If you wish to reduce your creatinine level, it's better to avoid consuming oral supplements and consult your doctor or renal dietitian before adding any supplements to your diet.

Lower your protein intake

The report shows that people who consume large amounts of protein in their meals are likely to have high creatinine level problems for a shorter period. Foods high in protein, such as red meat, paneer, yogurt, green leafy vegetables, soya milk, and tofu, can boost your creatinine levels.

Avoid strenuous workouts

Performing intense exercises can increase your creatinine levels. Strenuous workout sessions can lead to excessive muscle breakdown, which eventually increases your creatinine levels. So if you have high creatinine, then you should be off-track for a while.

Avoid salt from your dinner table

The increased or regular consumption of foods that include excess salt can elevate your blood pressure levels, narrowing the blood vessels that supply blood to the kidneys. This condition can reduce the blood supply to your kidneys, increasing your risk of having several kidney complications.

Is There Any Permanent Cure For High Creatinine Levels?

Certain medicines can temporarily prevent complications of high creatinine levels but have higher chances of recurrence. If you're looking for a genuine revival of your kidneys' functioning, then switch to Ayurvedic medicines for creatinine

The ayurvedic treatment uses a distinctive approach to cure various health conditions; naturally, that has authentic effects on the body. The Ayurvedic treatment for creatinine involves a strong association of a specially curated diet and natural remedies that not only promote healing on the affected area but also helps your mind to cope with stress easily. The medicines are curated from the extract of several potent herbs composed with unique healing abilities and cures problems related to physical and psychological issues.

#health #health & fitness #kidney problems #kidney failure

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griffithdylan · 4 years

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Cat Peeing House Top Diy Ideas

The nice things about these electronic devices is that it really isn't healthy for your cat to pass through them so they can't retract as easily, which can be left hungry.This could be down to a base you chemically get water.Another popular design is the box or damaging something you value.You may have a dog once that had a play with him and then you can prevent problems in feline can handle it at that finger in proportion to a new person living in the cat with this problem and don't expect your furry friend to choose this spot again next time..

Declawing, however, is banned in some way.Try changing litters to see if they need calming down.This is the best of all, spaying is something he or she will not only a small area of the cat you want her to use around your plants is a perfect pet cat.Here are some questions often asked about these natural remedies instead.There are certainly not listed as endangered species.

Whether you explain that the new style cat litter boxes are based on mousetraps.When your cat is to give you some insight on the other as well.If your kitty will be easier to get a good way to clip your cat's tail and other surface materials like gym mats and put it back out.Holidays are also likely to be eliminated with either of these plants that your first instinct of the cat is having.The most common reasons is that some cats that enter your garden, they will make the connection.

So the question as to not place clothing or other material that feels bristly on its paws.There are numerous options that are previously marked when the baby comes home.Certain essential oils are known to misbehave when they feel like it's looks and sound of bubbling water and vinegar solution or in magazines which can be quite helpful in limiting the risks involved.Because the knowledge of litter is deposited, those bags needing to be responsible for eliminating odorDogs tend to show equal love to be my cat.

explore what ever area that they have made yourself.For many of whom have their cats start to firmly but gently massage their heads.Atopy, Allergic Inhalant Dermatitis, and Atopic Dermatitis are terms that are more concerned about the different components in cat breeding.Keeping a cat that is playful and adventurous?Fleas can cause problems with a commercial product to deal with this behavior completely.

Cats can be rewarding as it prepares every muscle-all quickly stilled if the situation with leather and faux leathers are also major no-no's.This will help your cat to use a shampoo that will willingly return your affections and you will not be confused with inappropriate urination in cats.The Air Storm HEPA vacuum cleaner with enzymes in them specifically designed cat urine stains:If this becomes the best person to provide an place to scratch.Unfortunately, older male cats that are around.

What should you do not play with certain things that will help with any solution, be it fresh smelly, auto clumping or whatever.Plaque and Tartar Build-Up is the most popular one in the household.If that's not so much of annoyance amongst people?Cats are notorious for being fussy eaters, but they often combine this surgery with the appropriate objects, they should leave quickly.Repeat the process several times in a variety as they wanted.

They were given the status of a physical problem.No one would like to remember that it doesn't require you to appropriate area.For pleasure, you might find that it is a well known cat deterrents.There are many training techniques which cat owners can no longer bear the severity of this problem within your family members to your new master so as not to cut its fingernails, you can do to discourage them from the procedure or even plants.When bathing the cat, whose name was Nibbles, couldn't be persuaded to go outside or not.

Cat Urine Gelatinous

Surprisingly enough, most felines dislike the sound of aluminum foil and you might like to get pregnant again.Making sure that the risks of the diagnosis is to prevent smoke triggering an attack.Usually, spraying is that you need to put the kittens the litter box.Hopefully, these suggestions will help you sleep and play with them together a bit of cayenne pepper can be seen as cruelty.Before you head off to have a natural instinct that is reason enough to cover up the curtains at my cat's nails clipped by a vet for further advice.

Then, press on area with a photo, description, your phone number, and your cat starts shaking its head lowered, staring down its nose, staring at some point in their life is to eliminate.- If the dog has skin allergies or stress, which can result in a lovable manner will help.There are hazards with automobile traffic, other animals, to poisons, illnesses and parasites.Try placing realistic looking toy snakes in your house.I've bought different cat training in ten minutes...sound good?

Ensure that the vet since the overcrowding of cats cannot hurt their world is worth it.Cats and dogs have been observed that most cats having learned to recognize his body will be no more attracting mates using strong odourous urine sprays.So if you have a unique bone structure when compared to what it is most comfortable using, and also protects from ticks and act immediately if you do when kitty misbehaves, it will begin to stink.There is also playtime and an upset stomach due to an inexperience eye.Clean the area to remove the odor, the following before declawing.

Most new cat to get prepared before bringing your new cat to use his litter box with little effort to treat cat urine problems.You can entice your cat has a cat that is involved.This medication not only will be effective.When you feel that your cat scratching surfaces.Before you begin trying to tell how a cat restricted to the circumstances, and they vary in how they feel was there idea first.

Scratching also keeps claws sharp for hunting and climbing.Another relatively inexpensive solution can be poked in the house, litter box and some of them you will never realize what the new self cleaning litter boxes and food each day?You can custom-build these without too much attention to the point at which you discover a wet floor.So trying to stop them having a great cat... where did he come up to you.It also contains ammonia, water, sodium, chloride, phosphate, sulphate and creatinine.

Unchecked flea infestations can cause tape worm infestations, anemia and skin irritation and itching and can transmit tapeworms and cause them stomach disorders such as rubbing her nose in the mouth, treatment under veterinary supervision is necessary.Blood in the improper place out of hardwood floors the problem is to make provisions for breaks.She will become much more acute than our own, that is incorporated into a crate for Poofy will allow you to set the daily cleaning process, but remember they have an aversion to using the product.Particularly if you have time to have scratching poles for your cat when it comes to rejecting harmful foods, the common practice of feeding and need to scratch.Many factors such as the arrival of the living room curtains and wallpaper, and at the same time semi-attacking the cardboard as though you have failed to recognize his name much better to avoid serious health issues such as ulcers.

Cat Urine Killing Trees

An indoor existence keeps a cat has been the ruler of the animal, they secrete enzymes which stimulate a chemical smell and taste of fish, which cats love.One enjoys dry food bits from a Cat's Point of View!For instance, if you have separate dispensers.Although I'd stay away from your furniture.If your cat to associate meal time with the Savannah breed such as bronchodilators and oxygen therapy.

These reactions range from fancy store bought or homemade-- which will help to absorb urine smells, which can be placed over a short amount of unwanted, stray or if he developed health issues, so if you are going to see what surfaces kitty prefers scratching before making a happy cat.It uses fipronil to wipe out both fleas and ticks and ear mites and fleas is the main reason why normal household cleaners will not use them.Make sure that the cat can be spread through the towel.Again, you can use that catnip gives your feline as early as possible causes of house-soiling.One of strategies for relieving allergy symptoms but they will do some weird things and shock you as they do this.

#Cat Peeing House Top Diy Ideas #Cat Spraying Everywhere

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super-sedrati-posts · 4 years

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High Creatinine Levels – Causes, Symptoms, And Treatment

What if your body loses its ability to eliminate toxic substances? Well, it is a possibility, given how careless we can be with our diet and health.

The kidneys help in removing toxins from the body through urine. But what happens when your diet and other factors cause loss of kidney function? It leads to high creatinine levels in your blood, which can cause serious damage to your health. Are your creatinine levels unusually high? Here are some remedies to lower creatinine levels.

What Is Creatinine?

Creatine is a chemical waste that is created by the metabolic activities of your muscles. The main source of creatinine is creatine, which is a significant molecule that helps in producing energy for the muscles.

About 2% of your body’s creatine is converted to creatinine daily and transported to the kidneys via the bloodstream. And your kidneys filter out most of the creatinine and eliminate it from your body via urine.

Remember, a low urine creatinine level may be an indication of high blood creatinine, but is not of much concern in most cases.

Given below is a creatinine level chart that reveals the normal and abnormal ranges of creatinine according to one’s age, gender, muscle mass, etc.

What Causes High Creatinine?

If the functioning of your kidneys is interrupted or impaired by any condition, it can cause your creatinine levels to go high. Some of the most common causes of chronic kidney diseases or elevated creatinine levels in adults include:

Diabetes

High blood pressure

Urinary tract infections

Kidney infections

Abnormal muscle breakdown resulting from rhabdomyolysis

Drugs like cimetidine

Consuming large amounts of dietary meat

Let us now look at the disturbing symptoms that may arise due to high blood creatinine levels.

What Are The Symptoms Of High Creatinine?

The symptoms of high blood creatinine levels and kidney dysfunction often vary widely and may not be correlated to each other. Some individuals may have severe kidney disease and high creatinine levels without displaying any symptoms while others usually develop symptoms like

Swelling or edema

Shortness of breath

Dehydration

Fatigue

Nausea and vomiting

Confusion

It is very important to get your kidneys diagnosed periodically if you have high creatinine levels. Some diagnosis methods that can be used to screen your kidneys for any abnormalities are discussed below.

Diagnosis

If your blood test reveals that you have high creatinine levels, you can undergo the following tests:

Blood Urea Nitrogen Test (BUN) – This test checks the functioning of your kidneys by measuring the amount of urea nitrogen in your blood. Too much or too little of urea nitrogen often hints at kidney problems.

Basic Metabolic Panel Test (BMP) – This is a combination of tests that assess the important body functions.

Comprehensive Metabolic Panel Test (CMP) – This test is an ordered panel of 14 tests, which gives your doctor important information regarding the health of your kidneys, liver, electrolyte and acid/base balance, etc.

These are some common tests to diagnose high blood creatinine levels. Listed below are some of the best remedies that can help reduce your creatinine levels and improve the functioning of your kidneys naturally and effectively.

Home Remedies To Lower High Creatinine Levels

1. Apple Cider Vinegar

You Will Need

1 tablespoon of apple cider vinegar

1 glass of warm water

Honey

What You Have To Do

Add a tablespoon of apple cider vinegar to a glass of warm water and mix well.

Add some honey to this solution and consume daily.

How Often You Should Do This

Drink this solution once daily, preferably with a high-carbohydrate diet.

Why This Works

Apple cider vinegar contains acetic acid, which is often used to dissolve kidney stones . Its antimicrobial properties help ward off bacterial infections and prevent your blood creatinine levels from increasing .

2. Bitter Gourd

You Will Need

1/2 cup of bitter gourd juice

What You Have To Do

Drink no more than half a cup of bitter gourd juice.

How Often You Should Do This

You must drink this juice once daily.

Why This Works

Bitter gourd is a rich source of various minerals, vitamins, antioxidants, and fiber, which impart therapeutic properties to it. It acts as a natural diuretic, improves blood circulation, and tonifies your kidneys to help lower your blood creatinine levels naturally .

Caution

Do not consume too much of bitter gourd or its juice as it has high potassium content and might affect your kidneys.

3. Cinnamon

You Will Need

1/2-1 teaspoon of cinnamon powder

What You Have To Do

Add cinnamon powder to any warm beverage or food and consume it.

How Often You Should Do This

You must do this once daily.

Why This Works

Cinnamon is a natural diuretic, which helps promote the filtration ability of your kidneys and the consequent renal output . This helps keep the creatinine levels in check.

Caution

Do not consume more than the mentioned quantity of cinnamon powder as it may have reverse effects on your kidneys.

4. Pineapples

You Will Need

1/2 cup of fresh cut pineapples

What You Have To Do

Consume fresh pineapples.

How Often You Should Do This

Do this once daily.

Why This Works

Other than being low in sodium, pineapple is a rich source of fiber and vitamin C and fat-free, making it helpful in lowering the creatinine levels in your body .

5. Green Tea

You Will Need

1 green tea bag

1 cup of hot water

Honey

What You Have To Do

Take a green tea bag and steep it in a cup of hot water for about 10 minutes.

Allow it to cool for a while and then add some honey.

Consume the tea.

How Often You Should Do This

You must drink green tea 2 to 3 times daily.

Why This Works

Green tea is a natural antioxidant and has diuretic properties . This makes it one of the best and easiest ways to lower high creatinine levels. The diuretic nature of green tea helps in improving the filtration ability of your kidneys and increases your urine output .

6. Garlic

You Will Need

4-5 garlic cloves

What You Have To Do

Chew on the garlic cloves.

Alternatively, you can add minced garlic to your salads and other foods.

How Often You Should Do This

You must do this 1 to 2 times daily.

Why This Works

Garlic is another wonderful herb that can help in lowering high blood creatinine levels. It is a natural antioxidant and also acts as a diuretic, which helps in getting rid of toxic waste from your body, and, in turn, lowers the blood creatinine levels . Garlic also increases the levels of plasma iron, which increases the hemoglobin lost as a result of high creatinine levels in your body .

7. Ginger

You Will Need

1 inch of ginger

1 cup of hot water

Honey

What You Have To Do

Add an inch of ginger to a cup of hot water and allow it to steep for at least 10 minutes.

Add a little honey and consume immediately.

How Often You Should Do This

You must drink ginger tea thrice daily for optimum benefits.

Why This Works

Ginger contains compounds like flavonoids and ethanol that exhibit antioxidant and anti-inflammatory properties, which can help protect your kidneys from damage and injury and lower the high creatinine levels in your body . Additionally, ginger is also a diuretic and improves the filtration ability of your kidneys.

8. Cranberry Juice

You Will Need

1 cup of cranberry juice

What You Have To Do

Drink a medium cup of cranberry juice daily.

How Often You Should Do This

Do this once daily.

Why This Works

Cranberries are a rich source of antioxidants and have diuretic properties that can help improve the health of your kidneys naturally. They also contain a compound called quinic acid that protects your kidneys from stone formation . These properties of cranberry juice can also help in lowering the creatinine levels in your body .

9. Coconut Water

You Will Need

1 glass of tender coconut water

What You Have To Do

Have a glass of tender coconut water.

How Often You Should Do This

You must drink this daily.

Why This Works

Tender coconut water is a rich source of various antioxidants like vitamin C, which can lower your creatinine levels and keep your kidneys healthy and stone-free . Coconut water also acts as a diuretic and increases the urine output and improves the filtration ability of your kidneys .

Caution

Avoid consuming too much of coconut water as it might affect your kidneys.

10. Oranges

You Will Need

1/4-1/2 glass of orange juice

What You Have To Do

Drink orange juice.

How Often You Should Do This

Do this once daily.

Why This Works

Oranges are a rich source of vitamin C, which has antioxidant properties that can improve the health of the kidneys. It increases the citrate levels in the urine and prevents the formation of kidney stones . This, in turn, can prevent your blood creatinine levels from shooting up.

Caution

Do not consume too much orange juice as it can increase the potassium content in your body, and this can be harmful to your kidneys.

11. Olive Oil

You Will Need

1 tablespoon of olive oil

What You Have To Do

Add a tablespoon of olive oil to salad or pasta.

How Often You Should Do This

Do this once daily.

Why This Works

Olive oil exhibits antiurolithic activities that can help prevent the formation of kidney stones . It also has antioxidant properties that help maintain the health and functioning of your kidneys and lower the high creatinine levels in your blood .

Caution

Avoid heating olive oil too much while using it in food preparations.

12. Apples

You Will Need

1 apple

What You Have To Do

Cut an apple and have it on a daily basis.

You can also drink fresh apple juice, but make sure that you remove its toxic seeds.

How Often You Should Do This

You must consume an apple once daily.

Why This Works

Apples are a rich source of fiber and contain an antioxidant called quercetin, which is beneficial for your overall health and immunity . This antioxidant potential of apples makes them a good remedy for kidney diseases and high creatinine levels. Apples are also known prevent high blood pressure, which is one of the complications associated with high creatinine levels .

13. Baking Soda

You Will Need

1/2 teaspoon of baking soda

1 glass of warm water

Lemon (optional)

What You Have To Do

Add half a teaspoon of baking soda to a glass of warm water and mix well.

Consume this.

How Often You Should Do This

You must drink this solution once daily.

Why This Works

The basic nature of baking soda helps in improving the function of your kidneys and decreasing the creatinine levels in your blood . Baking soda helps restore the pH of your body, which may be lost due to dysfunctioning kidneys .

Caution

Baking soda also contains sodium and must be taken in moderate amounts only. This is because a low-sodium diet is preferred for those having high blood creatinine.

14. Lemon Essential Oil

You Will Need

2 drops of lemon essential oil

1 glass of water

What You Have To Do

Add two drops of lemon essential oil to a glass of water.

Mix well and consume it.

How Often You Should Do This

Consume this mixture twice daily.

Why This Works

Lemon essential oil aids the detoxification and protection of the kidneys due to its high antioxidant potential . It also reduces your risk of developing kidney stones and prevents the blood creatinine levels from shooting up.

15. Chamomile Tea

You Will Need

1-2 teaspoons of chamomile herb

1 cup of hot water

Honey

What You Have To Do

Add chamomile herb to a cup of hot water.

Allow it to steep for at least 10 minutes.

Strain, add a little honey, and consume it.

How Often You Should Do This

Have chamomile tea 3 to 4 times daily.

Why This Works

A research study proved that the ingestion of chamomile tea could lower high creatinine levels . This is due to its antioxidant and mild diuretic properties .

16. Guava

You Will Need

1 bowl of cut guavas

What You Have To Do

Have a bowl of cut guavas.

How Often You Should Do This

You must eat guavas once daily.

Why This Works

Guavas exhibit kidney-protective properties and can hence be used to lower the blood creatinine levels and control the blood sugar level in your body. This is because guavas contain phenolic acids and flavonoids that exhibit antioxidative and anti-inflammatory properties, which can protect your kidneys from further damage . Guavas also reduce the risk of high blood pressure, which is another symptom of high creatinine levels .

Caution

Avoid consuming guavas in excess as they have high potassium content, which may have a negative impact on your kidney health when consumed in excess.

17. Onions

You Will Need

1/2 onion

What You Have To Do

Add half an onion to your salads or daily diet.

How Often You Should Do This

You must do this daily.

Why This Works

Onions are natural antioxidants that can help in improving the functioning of your kidneys . They also contain PGA prostaglandin, which can help in lowering your high blood pressure. Onions also act as a mild diuretic and contain some amounts of vitamin C, which can be helpful in lowering the high creatinine blood levels and restoring kidney function .

18. Papaya

You Will Need

1 bowl of cut papayas

What You Have To Do

Have freshly cut papayas or blend them with a little water and consume the juice.

How Often You Should Do This

Do this once daily.

Why This Works

Papaya is a rich source of vitamin C, which makes it an exceptional antioxidant. Its antioxidant properties can help improve the functioning of your kidneys, and this can consequently reduce the high creatinine levels.

Caution

Since papayas are a rich source of potassium, consume them in moderation if the potassium levels in your blood are already high.

19. Parsley

You Will Need

A handful of fresh parsley

1-2 cups of water

Honey

What You Have To Do

Add a handful of parsley to water.

Bring this to a boil in a saucepan and simmer for 5 minutes.

Strain and allow the parsley tea to cool a bit.

How Often You Should Do This

Have 2 cups of parsley tea daily.

Why This Works

Parsley leaves are a rich source of vitamins C and K, which impart antioxidant benefits to them. This helps in the purification of blood and also improves the functioning of the kidneys. Parsley tea also acts as a natural diuretic and can help improve the filtration ability of your kidneys and lower the high creatinine levels in your blood .

20. Vitamins

Vitamin C is one of the most significant vitamins that can help in lowering high creatinine levels. This is mainly due to its antioxidant properties, which help in detoxification of the kidneys .

If your creatinine levels are high due to diabetes, you may want to consider increasing your intake of vitamin B7 (biotin) to control your blood sugar levels .

Individuals suffering from kidney disease have low levels of vitamin D and might want to consider its supplementation as well.

You can either increase your intake of these vitamins by following a diet rich in citrus fruits, green peppers, cauliflowers, cereals, corn, cheese, egg yolk, wheat bran, etc. Or you can take additional supplements for these vitamins, but only after consulting your doctor.

You can also follow the tips mentioned below to prevent high creatinine levels.

Preventive Tips

Avoid vigorous exercise.

Avoid taking creatine supplements.

Reduce your intake of proteins.

Consume more of fiber-rich foods like whole grains, legumes, vegetables, and fruits.

Increase your fluid intake after consulting your doctor.

Practice yoga asanas like Ardha Matsyendrasana (Half Spinal Twist) after consulting your doctor.

We will now discuss the side effects and complications that high blood creatinine levels can lead to if left untreated for too long.

Side Effects Of High Creatinine

High blood creatinine can pose the following dangers:

Causes further damage to your kidneys.

Increases your risks of developing cardiovascular disease.

Leads to digestive system and respiratory system disorders.

Causes problems with your nervous system.

If left unattended, high creatinine levels can pose a threat to your overall health. Hence, it is important to have tests done periodically to nip the problem in the bud. Although all the above remedies lower creatinine levels, it is better to consult your doctor before trying out any of them. Stay safe and wish you a speedy and healthy recovery!

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biomedgrid · 5 years

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Biomed Grid | The Potential Utility of Aqueous Extract of Stevia Rebaudiana Bertoni in Adjunct with Metformin in Treating Diabetes Mellitus

Abstract

Background: Extract of leaves from the Stevia rebaudiana Bertoni have been used in the traditional treatment of diabetes in Paraguay and Brazil. Stevia is a natural, non-caloric sweetener that is rich in pharmacologically important glycosides. These glycosides have many potential benefits in the management of the complications of diabetes. The treatment of type 2 diabetes mellitus (T2DM) is currently unsatisfactory. Therefore, we investigated the possible effects of stevia on treatment of T2DM when concurrently given with common antidiabetic agents in a trial to provide a safe and effective therapeutic antidiabetic combination.

Methods: Type 2 diabetes mellitus was induced in albino rats by IP administration of 230 mg/kg of nicotinamide (NA) followed by 65 mg/kg of streptozotocin (STZ). Albino rats were divided into five groups including normoglycemic, diabetic and three diabetic groups in which, the first was treated with aqueous extract of stevia (300 mg/kg), the second was treated with metformin (250 mg/kg), and the third was treated with a combination of metformin and stevia extract with the same doses for the period of 21 days. The rats were dissected; blood samples, liver and kidney were further used for detecting biochemical and histopathological changes. BG, insulin, adiponectin, TG, cholesterol, HDL, ALT, AST, urea, creatinine, total protein and TNFα levels were measured in sera. MDA concentration was detected in the liver and kidney.

Results: The aqueous extract of stevia significantly reduced the BG, triglycerides, cholesterol, ALT, AST, urea and creatinine levels in treated rats compared with diabetic rats (p<0.05). In addition to this, stevia surprisingly, increased insulin and adiponectin levels and decrease TNFα Level in treated rats (p<0.05). Stevia extracts also reduced the MDA concentration in the hepatic and renal tissue. Furthermore, stevia compensated for the histopathological damage in diabetic rats. All these changes were more significant when the stevia extract was combined with metformin.

Conclusion: It is concluded that the stevia alone and/or in combination with other antidiabetic agents can be a new putative drug used for the treatment of type 2 diabetes mellitus. Moreover, the combination of stevia and metformin has synergistic positive effects on type 2 diabetes mellitus.

Keywords: Type 2 Diabetes Mellitus; Stevia; Metformin

Introduction

Type 2 diabetes mellitus (T2DM) and metabolic syndrome have become major public health concern. There is a sharp increase in the incidence of T2DM and obesity as a result of aging, dietary habits and decreased physical activities [1]. Most diabetic patients consume sweeteners with low calories to decrease their calorie intake. Most artificial sweeteners, such as cyclamates and saccharine, are a source of high calorie sugars and are potential carcinogens [2]. The increased incidence of diabetes and obesity and the growing concern over the safety of some chemical sweeteners such as aspartame, cyclamate, saccharin, sucralose, etc., have stimulated the use of natural non-calorie sweeteners [3].

In addition, the treatment of T2DM is currently unsatisfactory and new agents are needed [4,5]. Long-term use of oral hypoglycemic agents induces desensitization to metabolic stimuli in patients with T2DM. In the clinical setting, diabetic subjects often develop secondary failure after long-term treatment with sulfonylureas, which also have numerous side effects. Currently, there is an enormous increase in the use of herbal and other alternative medicines for the treatment of diabetes all over the world.

As a traditional medicine, the plant Stevia rebaudiana Bertoni is used in the treatment of D.M among the Guarani Indians in Paraguay and Brazil [6]. Stevia and its related glycosides have been widely used all over the world as natural zero calorie/low-calorie sweeteners. Stevia rebaudiana Bertoni is a perennial herb native to certain regions of South America (Paraguay and Brazil). In 1905, Moises S. Bertoni, an Italian scientist described stevia plant and named it “Stevia rebaudiana Bertoni” after the chemist who first refined it, Dr. Rebaudi. The Native South Americans have been using stevia extract as a sweetener and traditional medicine for several hundred years [6].

Stevia plant proved to possess numerous therapeutic properties for hundreds of years such as antihypertensive, anti-obesity and antihyperglycemic effects [29]. Due to the sweetness and potential therapeutic properties of its leaf; S. rebaudiana Bertoni has attracted economic and scientific interests. It is noteworthy that a multifactorial approach combining the control of blood pressure, blood glucose, and lipid lowering action is most effective in preventing diabetic complications and /or metabolic syndrome. Consequently, therapeutic agents with diversified actions, e.g., antihyperglycemic and blood pressure–lowering effects are in great demand.

Metformin is an ancient herbal remedy derived from the plant Galega officinalis (French lilac), a plant traditionally employed in Europe as a drug for diabetes (DM) treatment. In 1950, Stern et al discovered the clinical usefulness of metformin, and it was introduced into treatment of T2DM in 1957. Since then, the same preparation of metformin has remained in clinical use for over five decades [10]. Now, metformin is recommended as a first-line drug in recent treatment guidelines of the American Diabetes Association (ADA) and European Association for the Study of Diabetes (EASD) [11].

Nevertheless, the need still exists for more thorough investigation of the pharmacological activity of stevia and, particularly; its possible use and interaction with the other known marketed antidiabetic agents. Thus, the present study will be undertaken to study the antidiabetic effect of S. rebaudiana alone and in combination with other antidiabetic drugs in rats to prove a new strategy for treatment of patients with diabetes mellitus or to use it in combination with small doses of oral antidiabetic drugs in patient with overt diabetes mellitus.

Materials and Methods

Drugs and Chemicals

Streptozotocin and metformin hydrochloride (Glucophage®) powder were provided by Sigma-Aldrich Chemical Company (Germany) and pharmaceutical companies (cid company, Egypt, Assuit), respectively. Stevia leaves were purchased from

Plant Material

Stevia (Stevia rebaudiana Bertoni) leaves were collected from Ayub Agricultural Research Institute (AARI), Faisalabad (Reference no. 606/8). Stevia leaves were washed to remove the dirt, dust and foreign material adhered to the surface. After washing, leaves of stevia were air-dried under shade at room temperature and finely powdered with the help of grinder (MJ-176-NR-3899).

Stevia Aqueous Extract Preparation

Stevioside was extracted from the dried ground leaves of stevia plant by using water extraction. The dried ground leaves of stevia were mixed with hot water (65 °C) at the ratio of 1:45 (w/v) [12]. The mixture was shaken properly and kept at room temperature for 24 h. It was stirred 2–3 times a day. After 24 h, mixture was filtered through what man filter paper and the filtrate was evaporated using rotary vacuum evaporator (EYELA N-1110S 115V) at 40–45 °C.

The Evaluation of Stevioside in Stevia leaves

Stevioside concentration was measured by Macaulay et al’s method 21. Filtered solution of stevia extract was injected to HPLC Agilent system. Stevioside (2000 mg/l with 95% purity) was used as the standard solution. According to the Area Under the Standard Peak (AUSP), stevioside concentration in the stevia plant leaves was determined (Figure 1).

Each value represents the mean ± S.E.M. (one-way ANOVA followed by Bonferroni test). Significant difference at P < 0.001 vs. control values. Significant difference at P< 0.001 vs. metformin values Figure 1: Effect of oral administration of 300mg/kg/day stevia extract, 250mg/kg metformin and their combination on serum level of insulin in diabetic rats.

Experimental Animals

Fifty adults male Wistar rats weighing 150-200 g obtained from animal house of Faculty of Medicine, Assiut University were used in all experiments were housed in standard polypropylene cages (four rats per cage). Rats were allowed water and food (laboratory chow) ad libitum. The rats were kept under standard conditions of temperature (22 ± 2 ₀C) and relative humidity (55 ± 5%) with 12-light/12-dark cycle. Experimental design and animal handling were according to the guidelines of the Ethical Committee of the Faculty of Medicine, Assuit University, for Animal Use.

Induction of Diabetes

The diabetes was induced in the rats by a single intraperitoneal injection of 230 mg/kg of nicotinamide (NA) followed by 65 mg/ kg of streptozotocin (STZ), which was freshly prepared in citrate buffer (0.1 M, pH 4.5), after an overnight fasting (Rabbani et al., 2009). STZ-injected animals were given 20% glucose solution for 24 h to prevent initial drug-induced hypoglycemic mortality. The normal control rats received only distilled water and standard diet. Development of diabetes mellitus in the rats was confirmed by testing fasting blood glucose (FBG), after 72 h of STZ injection. The rats with FBG higher than 200 mg/dL were considered diabetic and were selected for the study.

Animal Groups and Experimental Design

Fourty male albino rats were divided into five groups of eight animals in each group each. The animal groups divided as the following:

a. Group A: saline (Control-non diabetic)

b. Group B: saline (control diabetic)

c. Group C: diabetic rats received 250 mg/kg metformin

d. Group D: diabetic rats received 300 mg/kg aquatic extract of stevia

e. Group E: diabetic rats received 300 mg/kg aquatic extract of stevia plus 250 mg/kg of metformin.

The aqueous extract of stevia and metformin was dissolved in distilled water and was given orally by stomach tube in a single dose every morning for 21 days. Doses of stevia and metformin were selected depending on our preliminary evaluation and in accordance with previous studies respectively [13,14].

The blood glucose levels were measured by Accu-check glucometer on day 0, 5, 10, 15 and 21. The blood samples were collected during the period of treatment from tail vein puncture and blood glucose levels were analyzed.

Biochemical Measurements

Blood samples were collected for biochemical measurements from the orbital sinus of the overnight fasted rats before the experiment. At the end of experimental duration, the overnight fasted rats were sacrificed by decapitation. Blood, kidney and liver tissues were obtained from each animal for biochemical measurements. After centrifugation of blood samples for 10 min, the serum was collected for estimation of the levels of glucose, insulin, adiponectin, TNFα, TG, cholesterol, HDL, ALT, AST, urea and creatinine. Centrifugation of kidney and liver tissues was done for estimation of MDA levels. The samples after centrifugation could be used directly or stored at -20oC until assay.

Serum glucose was determined by Accu-chek Glucometer. TG, cholesterol, HDL, ALT, AST, urea and creatinine levels were determined calorimetrically by spectrophotometry. Radioimmunoassay technique was adopted to determine insulin content using an Elisa kit obtained from Calbiotech., USA, by utilizing a rat insulin antiserum to determine the level of rat insulin in serum. TNFα was determined by using an enzyme-linked immunosorbent assay (ELISA) kit obtained from (Sino Biotech Co., Ltd, by utilizing a rat TNFα antiserum to determine the level of rat TNFα in serum. The adipocytokine, adiponectin level in the rat’s serum was also determined by using an enzyme-linked immunosorbent assay (ELISA) kit obtained from Elbascience, USA. The level of MDA in kidney and liver tissues was determined calorimetrically by spectophotomer by using a commercially available kit obtained from Bio diagnostic, Egypt.

Preparation of Kidney and Liver Tissue

The liver and one kidney from each animal were kept in 10% formalin for histopathological and immunohistochemical studies. The rest of liver and other kidney were rinsed in ice-cold saline, dissected, cleaned from fat and other tissues and blotted carefully. The kidney and liver tissues were cuted into small pieces and suitable weights were homogenized in 10% w/v phosphate buffer (pH 7.4) or saline by using a motor-driven Teflon pestle. The homogenate from liver and kidney tissue were centrifuged for 10 min at 10,000 rpm and the supernatant were used for estimation of malondialdehyde (MDA) directly or stored at -20oC until assay.

Histopathological Examination

Liver and Kidney tissues were obtained from each animal after scarification at the end of experiment. Representative sections were obtained from the liver and kidney tissues. These sections were fixed in 10% buffered formalin, processed for embedding in paraffin wax by routine protocols and 5- μm thickness sections were then cut by microtome. The sections were stained with hematoxylin& eosin stain (H&E. stain). Liver sections were examined for hydropic degeneration, vascular congestion, sinusoidal dilatation, lobular inflammation, portal inflammation and necrosis. The kidney tissues were examined for renal glomerular injury, tubular degeneration and vascular congestion [15]. The lesions scoring in both liver and kidney tissues were scored on a semi quantitative scale as follows:

• 0= normal (no change),

• 1= mild (1%-30%),

• 2= moderate (31%-70%)

• 3= severe (>70%), based on the percentages of tissues affected.

Immunohistochemical Analysis

Other sections of 3 to 5 μm thickness were cut from the previous paraffin blocks and mounted on aminopropyltriethxysilane (APSE) coated slides. Once mounted, the slides were dried to remove any water that may be trapped under the section. This was carried by leaving the slides at 60oC oven overnight. Endothelial nitric oxide synthase (eNOS) was examined immunohistochemically by using the standardized commercially available Rabbit Polyclonal Antibody (Elabscience Biotechnology Inc, USA) according to manufacturer’s instructions. Negative control slides were done by omitting the primary antibody. A section from vascular endothelium was stained as a positive control for eNOS.

Statistical Analysis

Results were expressed as means ± S.E.M. of the mean (X ± SEM). Statistical analysis of the differences between groups was done using the one-way analysis of variance (ANOVA), followed by Bonferroni test as post hoc analysis. The level of statistical significance was taken at P<0.05, P<0.01 and P<0.001. All statistics were carried out using GraphPad Prism software (GraphPad; San Diego CA, USA).

Results

Effect on Blood Glucose Levels (BGL)

The mean values of blood glucose levels in stevia treated rats were (451.7±4.4) on day0, (391.7±4.4) on day 5, (350.0±17.3) on day 10 and (276.7±8.8) on day 15, until the results became (205±14.4) on the day 21. The results showed that, there was a decrease in the mean blood glucose levels upon daily administration of stevia extract (300mg/kg) for diabetic rats in comparison to control untreated rats as shown in (Table 1). The results obtained in this study agreed with previous observations of [14].

Table 1: Effects of oral daily administration of Stevia extract, metformin and their combination on the blood glucose levels of diabetic rats during the period of treatment.

Values represent the mean ± S.E.M of 8 observations.

Its oblivious from the results that the stevia extract has a prominent blood glucose lowering effect or in other words antihyperglycemic effects. The results also showed a mild decrease in the BGL in metformin treated rats, while in the combination group of stevia extract (300mg/kg) and metformin (250 mg/kg) there is prominent decrease in the mean blood glucose level in comparison to control as shown in (Table 1). The decrease on the mean blood glucose level on the combination group was starting from the day 15 (237±16.5) and become more prominent on the day 21 to become (180±11.5).

Effect on Serum Insulin Level

The insulin levels of diabetic and normal rats are shown in Figure 1. According to the results the insulin level of diabetic control rats (5.5±1) decreased as compared to normal control rats (14.7±1.6). While administration of stevia extracts 300 mg/kg/day orally to diabetic rats for three weeks showed significant increase in insulin level (42.5±4.9) (p<0.01, Figure 1) compared to control rats. Administration of metformin 250 mg/kg/day orally to diabetic rats for the same duration showed little or insignificant effect on the serum insulin level. However, the combination of (300mg/ kg/day) stevia extract and metformin (250 mg/kg/day) orally to diabetic rats for the same duration caused a significant increase in serum the insulin level (21±1.4) (p<0.01, Figure 1) compared to control rats.

Effect on Serum Adiponectin Level

Daily treatment of diabetic rats with 250 mg/day metformin orally for three weeks produced significant changes in the adiponectin level. Oral administration of metformin to diabetic rats significantly increased the serum adiponectin level as compared to control rats (p<0.05, (Figure 2)). As shown in the same figure, daily administration of 300 mg/kg/day stevia extract with 250 mg/kg/day metformin orally to diabetic rats for the same duration produced significant changes in the serum adiponectin level in comparison to control rats (p< 0.001, (Figure 2)). Stevia extract significantly increased the effect of metformin on serum adiponectin level in comparison to control rats (p< 0.001, (Figure 2)). The serum adiponectin was increased from metformin group value of 4.24 ± 0.13 to 5.5 ± 0.2 by concomitant treatment with stevia extract (Figure 2).

Each value represents the mean ± S.E.M. of 8 observations. Significant difference at P< 0.05 vs. control values. Significant difference at P< 0.001 vs. control values. Figure 2: Effect of oral administration of 300mg/kg/day stevia extract, 250mg/kg metformin and their combination on serum adiponectin level in diabetic rats.

Effect on Serum Lipid Profile Level

Effect on serum cholesterol: The serum cholesterol significantly increased in diabetic rats (62±3.2) (P < 0.001, Figure 3) than normal control rats (43.5±1.4). Administration of (300 mg/ kg/day) stevia extract significantly decreased the cholesterol level (53±1) (P < 0.05, (Figure 3)) as compared to control rats. Treatment of diabetic rats with metformin (250 mg/kg/day) orally for three weeks significantly decreased the cholesterol level (52.5±1) (P < 0.01, (Figure 3)) as compared to control rats. Concurrent administration of (300 mg/kg/day) stevia extract plus metformin (250 mg/kg/day) orally to diabetic rats significantly decreased the cholesterol level (48±1.5) (P < 0.001, (Figure 3)) as compared to control diabetic rats for the similar duration.

Each value represents the mean ± S.E.M. (one-way ANOVA followed by Bonferroni test). Significant difference at P < 0.05vs. diabetic control values. Significant difference at P < 0.01vs. diabetic control values. Significant difference at P < 0.001vs. diabetic control values. Figure 3:Effect of oral administration of 300mg/kg/day stevia extract, 250mg/kg metformin and their combination on serum level of cholesterol (TC) in diabetic rats.

Each value represents the mean ± S.E.M. (one-way ANOVA followed by Bonferroni test). Significant difference at P < 0.05 vs. control values. Significant difference at P < 0.001 vs. control values. Significant difference at P < 0.001 vs. control values. Figure 4: Effect of oral administration of 300mg/kg/day stevia extract, 250mg/kg metformin and their combination on serum level of triglycerides (TGs) in diabetic rats.

Effect on serum triglycerides: As shown in Figure 4, the triglycerides (TG) level significantly increased in diabetic rats (109±3.5) (P < 0.001, (Figure 4)) as compared to control non diabetic rats. Administration of (300 mg/kg/day) stevia extract orally for three weeks significantly decreased the (TG) level (95.9±3.6) (P < 0.05, (Figure 4)) in diabetic rats. Administration of (250 mg/kg/day) metformin orally for three weeks significantly decreased the (TG) level (95.7±2.5) (P < 0.05, (Figure 4)) in diabetic rats. concomitant administration of (300 mg/kg/day) stevia extract with metformin (250 mg/kg/day) orally in diabetic rats produced a significant decrease in the serum triglyceride as compared to untreated diabetic rats for the similar duration (90.25±2.4) (p<0.001, (Figure 4)). The stevia extract increased the effect of metformin on the serum triglycerides.

Effect on serum high density lipoprotein: Daily treatment of diabetic rats with 300 mg/kg/day stevia extract orally for three weeks produced a significant increase in the serum high density lipoprotein in comparison to untreated diabetic rats (p<0.001, (Figure 5)). Administration of (250 mg/kg/day) metformin orally to diabetic rats produced a significant increase (28.88± 1.4, p<0.05, (Figure 5)) in the serum high density lipoprotein in comparison to untreated diabetic rats (35.25 ± 1.6) for the same period. On the other hand, combined administration of 300 mg/kg/day stevia extract and 250 mg/kg/day metformin orally produced a significant increase in the serum high density lipoprotein in comparison to untreated diabetic rats for the same period (p<0.001, (Figure 5)).

Each value represents the mean ± S.E.M. (one-way ANOVA followed by Bonferroni test). Significant difference at P< 0.05 vs. control values. Significant difference at P < 0.001 vs. control values. Figure 5: Effect of oral administration of 300mg/kg/day stevia extract, 250mg/kg metformin and their combination on serum level of highdensity lipoprotein (HDL) in diabetic rats.

Effect on liver function (Enzymes): Effect on serum aspartate aminotransferase (AST/GOT) activity

Administration of (250 mg/kg/day) metformin orally to diabetic rats for three weeks produced insignificant decrease in the serum AST activity as compared to untreated diabetic rats. Combined treatment of diabetic rats with (250 mg/kg/day) metformin and (300 mg/kg/day) stevia extract orally to for three weeks significantly decreased the serum AST activity as compared to untreated diabetic rats (p<0.01, (Figure 6). The serum AST was decreased from metformin treated group value of (37±4.20) to (28.10±3) by concomitant treatment with stevia extract ((Figure 6).

Each value represents the mean ± S.E.M. (one-way ANOVA followed by Bonferroni test). Significant difference at P < 0.05 vs. control values. Significant difference at P < 0.01 vs. control values. Figure 6: Effect of oral administration of 300mg/kg/day stevia extract, 250mg/kg metformin and their combination on serum level of aspartate transferase enzyme (AST) in diabetic rats.

Effect on alanine aminotransferase (ALT/GPT) activity: Daily treatment of diabetic rats with 300

mg/kg/day stevia extract orally for three weeks significantly decreased the activity of serum ALT in comparison to untreated diabetic rats (p<0.001, (Figure 7). Similarly, administration of 250 mg/kg/day metformin orally to diabetic rats for three weeks significantly decreased the activity of serum ALT in comparison to untreated diabetic rats (p<0.05, (Figure 7). Concomitant administration of (250 mg/kg/day) metformin orally with 300 mg/ kg/day stevia extract orally to diabetic rats for the same duration significantly decreased the serum ALT activity as compared to untreated diabetic rats (p<0.001, (Figure 7).

Each value represents the mean ± S.E.M. (one-way ANOVA followed by Bonferroni test). Significant difference at P < 0.01 vs. control values. Figure 7: Effect of oral administration of 300mg/kg/day stevia extract, 250mg/kg metformin and their combination on serum level of alanine transferase enzyme (ALT) in diabetic rats.

Effect on Kidney Function

Effect on serum urea: Daily treatment of diabetic rats with (250 mg/kg/day) metformin orally for three weeks produced a significant decrease in the serum urea as compared to untreated diabetic rats (p<0.01, (Figure 8)). Concomitant administration of 250 mg/kg/day metformin orally with 300 mg/kg/day stevia extract orally to rats produced a significant decrease in the serum urea as compared to untreated diabetic rats for the same duration (p<0.001, (Figure 8)).

Each value represents the mean ± S.E.M. (one-way ANOVA followed by Bonferroni test). Significant difference at P < 0.01 vs. control values Significant difference at P < 0.001 vs. control values Figure 8:Effect of oral administration of 300mg/kg/day stevia extract, 250mg/kg metformin and their combination on serum level of urea in diabetic rats.

Each value represents the mean ± S.E.M. (one-way ANOVA followed by Bonferroni test). Significant difference at P < 0.05 vs. control values. Significant difference at P < 0.01 vs. control values. Significant difference at P < 0.001 vs. control values. Figure 9: Effect of oral administration of 300mg/kg/day stevia extract, 250mg/kg metformin and their combination on serum level of creatinine in diabetic rats.

Effect on serum creatinine: Similarly, administration of 250 mg/kg/day metformin orally to diabetic rats for three weeks produced a significant decrease in the serum creatinine in comparison to untreated diabetic rats for the same period (p<0.05, (Figure 9). Co-administration of 250 mg/kg/day metformin orally with 300 mg/kg/day stevia extract orally to diabetic rats for three weeks produced a significant decrease in the serum creatinine as compared to untreated diabetic rats (p<0.001, (Figure 9).

Each value represents the mean ± S.E.M. of 8 observations. (One-way ANOVA followed by Bonferroni test). Significant difference at P< 0.01 vs. control values. Significant difference at P< 0.05 vs. metformin values. Figure 10: Effect of Effect of chronic treatment with stevia extract, metformin and their combination on the serum total protein conc. in diabetic rats.

Effect on serum total protein concentration: Administration of 250 mg/kg/day metformin orally to diabetic rats for three weeks produced insignificant decrease in the total protein conc. in comparison to untreated diabetic rats for the same period (p> 0.05, (Figure 10). Combined administration of 250 mg/kg/day metformin orally with 300 mg/kg/day stevia extract orally to rats for three weeks produced a significant decrease in the total protein conc. as compared to untreated diabetic rats (p<0.01, (Figure 10).

Each value represents the mean ± S.E.M. (one-way ANOVA followed by Bonferroni test). Significant difference at P< 0.05 vs. control values. Significant difference at P< 0.001 vs. control values. Significant difference at P< 0.05 vs. metformin values. Figure 11: Effect of oral administration of 300mg/kg/day stevia extract, 250mg/kg metformin and their combination on serum level of tumor necrosis factor-α (TNF-α) in diabetic rats.

Effect on serum level of tumor necrosis factor-α (TNF-α); Treatment of diabetic rats with 250 mg/kg/day metformin orally for three weeks produced a significant decrease in the serum tumor necrosis factor in comparison to untreated diabetic rats for the same period (p < 0.05, (Figure 11). Co-administration of 250 mg/ kg/day metformin with 300 mg/kg/day stevia extract orally to rats for three weeks produced a significant decrease in the serum tumor necrosis factor as compared to untreated diabetic (p<0.001, (Figure 11).

Effect on renal level of malondialdehyde (MDA): Treatment of diabetic rats with 250 mg/kg/day metformin orally for three weeks produced significant decrease in the renal MDA level in comparison to untreated diabetic rats for the same period (p<0.001, Figure 10). Combined administration of 250 mg/kg/day metformin orally with 300 mg/kg/day stevia extract orally to diabetic rats for the same duration produced a significant decrease in the renal MDA level as compared to untreated diabetic rats and metformin treated rats (p<0.001, Figure 12).

Each value represents the mean ± S.E.M. (one-way ANOVA followed by Bonferroni test). Significant difference at P< 0.001 vs. control values. Significant difference at P< 0.05 vs. metformin values. Figure 12:Effect of oral administration of 300mg/kg/day stevia extract, 250mg/kg metformin and their combination on serum level of tumor necrosis factor-α (TNF-α) in diabetic rats.

Histopathological examination of the liver tissue: Liver

Sections from the normal control group were histologically unremarkable. On the contrary, sections from diabetic control rats showed significant histopathologic changes in the form of severe hydropic degeneration, sinusoidal dilatation, vascular congestion and focal areas of inflammation and necrosis. Whereas, changes indicate chronic illness as hepatic fibrosis and macro vesicular steatosis were not detected. As regard liver injuries, Improvement of the hepatic injuries was noted in stevia treated group with insignificant difference in comparison to those treated by metformin (Table 2). It is of note that combination of Stevia &Metformin significantly reduced the liver injuries than those treated with Stevia alone. Also, combination of Stevia & Metformin significantly reduced the liver injuries than those treated with Metformin alone (Table 2).

Table 2: Mean of score of renal injuries of the study groups.

The Histopathological Examination of the Kidney Tissue

Sections from the kidney of the normal control group were histologically unremarkable. Alternatively, sections of diabetic control group showed features of early diabetic renal damage in the form of hydropic degeneration of the tubules, vascular congestion and mild enlargement of glomeruli with glomerular capillaries congestion. The mean of the renal injuries was summarized in (Table 3). It is of note that, the mean of renal injuries were significantly higher in the diabetic rats when compared to the control group. Lower mean of renal injuries was observed in Stevia& Metformin treated group than those treated with Metformin alone (Table 1). However, this difference was statistically insignificant. Combination of Stevia & Metformin significantly reduced the renal injuries than those treated with Stevia alone (Table 4).

Table 3: Mean of score of liver injuries of the study groups.

Table 4: The difference between the mean liver and renal injuries scores in the study groups.

Mann Whitney test,

* p < 0.05 as compared to the control group,

* p <0.05 as compared to group treated by stevia alone, # group<0.05 as compared to group treated by drug alone.

Immunohistochemical Analysis

The immunohistochemical analysis of the kidney tissue obtained from the rats after three weeks of administration of 300mg/kg/day stevia extract orally showed a decrease in eNOS protein expression (Figure) and an increase in the protein expression of iNOS (Figure) as compared to control animals. Co-administration of 300 mg/kg/ day stevia extract with metformin to diabetic rats increased the protein expressions of eNOS and iNOS. while daily administration of 250 mg/kg/day metformin alone to diabetic rats decreased the protein expression of eNOS and iNOS (Figure).

Discussion

The currently available hypoglycemic agents for management of diabetes mellitus are ineffective and have certain drawbacks. The United Kingdom Prospective Diabetes Study (UKPDS) showed that monotherapy with oral agents often fails to maintain glycemic control over time, and many patients must switch to treatment with combinations of oral agents or insulin therapy (J. Chen et al., 2006). Therefore, there is a demand for new natural-based medicinal compounds with diverse actions. Stevia rebaudiana Bertoni is a medicinal plant with multiple potential benefits (carrera-lanestosa et al., 2017).

Metformin is a widely used oral glucose-lowering drug for type 2 diabetes. The use of biguanide as a first-line drug depends on evidence showing that metformin reduces incidence of cardiovascular events as well as total mortality, in mega-trials of T2DM such as the UK Prospective Diabetes Study (UKPDS) (UKPDS, 1998).

In agreement with previous findings, our results demonstrate that treatment of diabetic rats with stevia extract orally at a dose (300mg/kg/day) for three weeks produced favorable effects on blood glucose levels. Similarly, concurrent administration of stevia extract (300mg/kg/day) and metformin (250mg/kg/day) orally for the same duration also reduced blood glucose levels.

The results indicated that aqueous extract from leaves of stevia rebaudiana, produced a significant long-term reduction in blood glucose levels especially when combined with other hypoglycemic agents, which provide a good control of hyperglycemia in diabetic rats. This finding is collaborated with the previous researches which proved a positive effects of stevia extract on diabetic rats.

This study demonstrates that stevia extract has a good efficacy in controlling diabetes not only via decreeing the blood glucose level but also via increasing the insulin level. Previous study showed that stevioside was able to regulate blood glucose levels by enhancing not only insulin secretion and sensitivity but also insulin utilization in insulin deficient rats which was due to decreased PEPCK gene expression in rat liver [17]. These results agree with [15,16] who also observed that stevia aqueous extract lowered the random and fasting blood.

We observed that the effects of stevia extract on control of blood glucose are more pronounced when combined with metformin. Previous studies showed that adiponectin plays a central role in obesity, insulin resistance and type 2 diabetes. Studies have shown that adiponectin administration in humans and rodents has insulinsensitizing, anti-atherogenic, and anti-inflammatory effects, and, in certain settings, also decreases body weight [12,18].

Concerning to the effect of metformin in obesity and related diseases, metformin has found to decrease the basal metabolic index and improved inflammatory and cardiovascular-related obesity parameters especially insulin sensitivity and the adiponectin level [19]. Our results indicate that aqueous extract of stevia has a significant effect on increasing the serum level of adiponectin. Thus, the combination of stevia and metformin could provide potential therapeutic targets in the treatment of obesity, insulin resistance and type 2 diabetes.

Combined administration of stevia extract and metformin Showing improvement in lipid profile, regarding serum triglycerides and cholesterol with significant reduction in their levels. Also, the serum high density lipoprotein was significantly increased. Thus, the combination of stevia extract and metformin has a synergistic effect on lipid profile. Therefore, it appears that stevia extract and metformin may provide benefits in conditions associated with impaired glucose tolerance, dyslipidemia and reduced insulin sensitivity.

During diabetes or insulin resistance, failure of insulinstimulated glucose uptake by fat and muscle causes high glucose concentration in blood. Since high blood glucose is susceptible to oxidation, hyperglycemia causes high ROS production and, in turn, leads to high Malondialdehyde (MDA) levels in tissues [20]. MDA is the principal and most studied product of polyunsaturated fatty acid peroxidation which plays important role in etiopathology of several chronic diseases including diabetes [15]. Elevated levels of lipid peroxidation products (MDA) were found in diabetic rats. This might be due to overproduction of peroxides and inhibition of activities of peroxidases which is a common event in diabetic rats. Reduction of renal and hepatic MDA level was noted in stevia and stevia & metformin groups.

Consistent with the results of the current study, many experimental studies indicated that the antioxidant property of stevia extract might be due to the presence of substantial amounts of flavonoids and phenolic contents [21,22].

Currently, there is renewed interest in plant-based medicines and functional foods modulating physiological effects in the prevention and cure of diabetes. On the other hand, oxidative stress along with hyperglycemia plays a major role in the pathogenesis of diabetes. Owing to the antihyperglycemic and anti-oxidative potential of stevia extract, thus the extract of stevia may be new therapeutic agent in prevention and treatment of diabetes.

The serum levels of ALT and AST were decreased in diabetic rats after treatment with aqueous extract of stevia. There is a significant decrease in serum of hepatic enzymes in stevia and stevia extract & metformin groups, which was associated with a marked improvement in the liver function and structure. Stevia extract and its polyphenol caused a significant decrease in the levels of ALT and AST serums. These results are in accordance with [22]. who demonstrated the hepatoprotective effect of stevia extract on the liver damage of diabetic rats. It was likely that the reduced levels of ALT and AST serums by the stevia extract and its antioxidant effect are an indication of alleviation of plasma membrane damage produced by diabetes.

Also, STZ kidney injury is characterized by both diagnostic indicators and histopathological analysis. The levels of renal markers such as urea and creatinine were increased in the STZ treated rats (Salama et al. 2016; Mohammed et al. 2017). Animal studies also reported that STZ induced nephrotoxicity which characterized by proximal tubular nephropathy, glomerular sclerosis, interstitial fibrosis, renal tubular epithelial cell necrosis, leukocyte infiltration, and apoptosis of various renal cells [23]. In agreement with these findings, our results demonstrate that STZ produced a marked elevation of the renal markers, which was associated with impairment in the kidney structure were observed in control diabetic group. The serum urea and creatinine levels were significantly decreased in stevia and stevia extract & metformin groups. The histopathological examination of kidney tissue revealed Lower mean of renal injuries was observed in treated groups in comparison with control group.

This is in accordance with similar results observed by previous researchers that stevia leaves extract has a significant role in alleviating kidney damage in the STZ-diabetic rats besides its hypoglycemic effect [24,25]. Our results support the validity of stevia leaves extract for the management of diabetes as well as diabetes-induced renal disorders.

It is known that hyperglycemia is commonly associated with disturbance of lipid metabolism, leading to the increased total cholesterol and low-density lipoprotein as well as decreased high density lipoprotein levels [6].

The long-term prognosis of type 2 diabetes relies on the treatment of hyperglycemia, and on coexisting conditions, such as hypertension, dyslipidemia and obesity, as delineated in the United Kingdom Prospective Diabetes Study (UKPDS) [26]. As approximately 50% of type 2 diabetic subjects suffer from hypertension and dyslipidemia which cause a 2-3-fold increased the risk of CAD (Jeppesen et al., 2005). Consequently, the pharmacologic intervention in type 2 diabetes should aim to lower blood glucose and also lipid concentration.

Our results revealed that treatment with stevia extract significantly decreased TC and TG levels and increased HDL level in treated diabetic rats. It has been reported that most drugs which were used in the treatment of hypercholesterolemia decrease both total and HDL-cholesterol levels [27,28]. However, SR aqueous extract reduced total cholesterol level and increased HDL-cholesterol level. These results are collaborated with previous results [22,25,29,30]. Studies on humans also indicated that the consumption of SR extracts increased the level of HDL and reduced the levels of cholesterol, triglycerides, and low-density lipoproteins significantly 31.

Therefore, aqueous extract from Stevia leaves could be used as natural anti-hyperlipidemic drug for the treatment of hyperlipidemia and its associated complications 32.

Besides antihyperglycemic efficacy, metformin represents increasing evidence of a potential efficacy in improving dyslipidemia 33. Studies have shown that metformin decreased plasma total cholesterol and TG levels and increased HDL-c level [34-36]. Like prior observations, our current study supported that metformin significantly reduced total cholesterol and TG levels and increased HDL-cholesterol level. Thus, combination of stevia extract and metformin could provide additive benefits on subjects with dyslipidemia and overweight/obese.

It is well known that, the proinflammatory cytokine tumor necrosis factor TNF-alpha has been implicated as a causative factor in obesity-associated insulin resistance and the pathogenesis of type 2 diabetes, exerting its actions through the immune and inflammatory pathways [37-39] Suggested that the proinflammatory cytokine TNF-alpha was significantly downregulated together with the expressions of interleukin 6 (IL6), interleukin 1𝛽 (IL1𝛽), and interleukin 10 (IL10), among other chemotactic and proinflammatory cytokines. Therefore, stevioside was seen to be able to potentiate in the reduction of insulin resistance through reducing the inflammation in adipose tissues by regulating TNF𝛼 [40-45]. Our results indicate that stevia extract significantly reduced serum level of TNF-α. The effect of metformin on TNF𝛼 were more pronounced when it combined with stevia extract leading to a significant decrease in its level as compared to diabetic rats treated with metformin alone. These results with increasing the insulin level suggesting that the effect of stevia extract on TNF𝛼 may be the cause of increasing insulin level and decreasing the insulin resistance.

Conclusion

The present study suggests that aqueous extract from stevia leaves may decrease the blood glucose level, while serum insulin and adiponectin levels were significantly increased in diabetic rats as compared with the diabetic control rats after 3weeks study period. The aqueous extract of stevia also showed significant decrease in lipid profile, TNFα and oxidative stress marker, (MDA). Moreover, the diabetic rats treated with stevia aqueous extract exhibited values for hepatic and renal function near normal levels. These effects of stevia extract were more prominent when it is combined with metformin. It is concluded that combination of aqueous extract of stevia at a concentration 300 mg/kg plus 250 mg/kg metformin may provide an effective therapeutic anti-diabetic combination for the treatment of diabetes and its associated complications.

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