#public12

[sinfonia-relativa]

Al final del día, ¿De que sirve agradar a los demas? Si, tu mundo interior es lo que siempre enfrentas.

Sad_Boy☕

[letras-temporales]

[desorden-en-letras]

Quizás debas conocer la oscuridad antes de poder apreciar la luz.

Madeleine L'Engle / Sept 14

[usstcowboypostsstudentupendo]

The Legend of Zelda : Breath of the Wild Jeu Wii U

79€00

Les points forts :

Plateforme : Wii U

Edition : Standard

Genre du jeu vidéo : Action, Jeu de rôle

Date de sortie marché : 03 Mars 2017

Nombre de joueurs : En local : 1-1

Durée de vie : 84 heures

Editeur : Nintendo

Informations générales sur le produit Marque NINTENDO Licences Zelda Nom du produit The Legend of Zelda : Breath of the Wild Jeu Wii U Catégorie JEUX WII U Informations Générales Titre du jeuThe Legend of Zelda : Breath of the Wild PlateformeWii U Date de sortie marché03 Mars 2017 EditionStandard EditeurNintendo Studio de développementNintendo Gamme de produitJeu Support du produitDisque Wii U Durée de vie84 heures Description du produitEntrez dans un monde d'aventure ! Oubliez tout ce que vous savez sur les jeux The Legend of Zelda. Plongez dans un monde de découverte, d'exploration et d'aventure dans The Legend of Zelda: Breath of the Wild, un nouveau jeu qui vient bouleverser la série à succès. Voyagez à travers champs, traversez des forêts et grimpez sur des sommets dans votre périple où vous explorez le royaume d'Hyrule en ruines à travers cette aventure à ciel ouvert. Plus produit- Explorez les contrées sauvages d'Hyrule à votre guise Escaladez des tours et montagnes à la recherche de nouvelles destinations : trouvez votre propre voie à travers ces contrées sauvages. Au long de votre route, vous combattrez des foules d'ennemis, vous chasserez du gibier et rassemblerez des ingrédients nécessaires pour vous nourrir et créer des potions qui vous aideront à survivre dans votre périple. - Plus de 100 sanctuaires à découvrir et à explorez Les sanctuaires qui sont disséminés sur le territoire ne demandant qu'à être découverts, et dans l'ordre de votre choix. Partez à leur recherche de plusieurs manières et résolvez différentes énigmes. Prenez garde aux pièges et aux périls qui vous y attendent pour obtenir des objets spéciaux et d'autres récompenses qui vous aideront dans votre aventure. - Préparez-vous et équipez-vous en conséquence Avec ce monde gigantesque que vous vous apprêtez à explorer, vous aurez besoin de diverses tenues et équipements pour pouvoir atteindre chaque recoin. Il vous faudra probablement de quoi vous tenir chaud dans les contrées glacées et quelque chose de léger pour affronter les chaleurs du désert. Certaines tenues ont également des effets spéciaux vous permettant par exemple de vous rendre plus rapide et furtif. - Combattre les ennemis requiert de la stratégie Le monde est habité d'ennemis de toutes formes et de toutes tailles. Chacun d'eux possède sa propre méthode d'attaque et des armes spécifiques, il vous faudra dont réfléchir vite et développer les stratégies gagnantes pour en venir à bout. - Compatibilité avec les amiibo En scannant l'amiibo de Link loup (vendu séparément), Link loup apparaît dans le jeu pour attaquer les ennemis de manière indépendante et vous permettre de trouver des objets que vous recherchez. Nous présenterons également de nouveaux amiibo de la série The Legend of Zelda: Breath of the Wild à l'E3 de cette année. Durée de vie du jeu Histoire principale: 44 h Histoire principale + quêtes annexes: 87 h 1/2 Jeu complété à 100%: 172 h Durée de vie moyenne: 84 1/2 Compatible VRNon Compatible Playstation VRNon Style de Jeu Genre du jeu vidéoAction Jeu de rôle PEGI - Public12+ PEGI - ClassificationViolence Nombre de joueursEn local : 1-1 Rating USK12 Rating ESRBEnfants et adultes 10+ Rating ESRB - DescriptionThèmes suggestifs modérés Usage d'alcool Violence fictive Compatibilité Mode réseauNon Mode en ligneNon

[babymilkaction]

Commercial interests, transparency, and independence: a call for submissions

PDF

Commercial interests, transparency, and independence: a call for submissions. Help the move towards independence from commercial interests.

Submissions are welcome from now, with a final deadline of 15 January 2020.

Ray Moynihan assistant professor 1, Helen Macdonald UK research editor 2, Carl Heneghan professor, Lisa Bero professor 4, Fiona Godlee editor in chief 2 1Centre for Research in Evidence-Based Practice, Bond University, Gold Coast, Australia; 2The BMJ, London, UK; 3Nuffield Department of Primary Care, Oxford University, Oxford, UK; 4Charles Perkins Centre, University of Sydney, Sydney, Australia

A decade ago the US Institute of Medicine (IOM) issued a landmark report on conflicts of interest in research, medical education, and practice.1 Highlighting benefits of collaborations between physicians, researchers, and companies to develop new products that can improve health, the report also raised substantial concerns that extensive financial ties could unduly influence professional judgments. It concluded these financial conflicts of interest could jeopardise the integrity of science, the objectivity of education, the quality of care, and public trust in medicine. The report recommended more research on conflicts of interest, improvements in transparency, and greater independence from industry.

Today we announce plans for a stream of BMJ content to revisit these concerns and ask you to join us. A key aim is to identify and respond to commercial influences on health and healthcare, to understand under what circumstances involvement with industry is truly necessary. Where it is not necessary, we want to forge a new independence from those who make and sell products, to strengthen trust in how evidence is produced and disseminated, and to drive more rational and safer use of drugs, devices, diagnoses, and data in the public interest.

Problematic relationships Since the 2009 IOM report, transparency has improved, but key recommended steps towards independence—such as prohibiting free meals, excluding conflicted authors from guidelines, and ending industry influenced medical education—have not been taken. These practices are still widespread despite continuing evidence of distorting impacts on research and practice. A 2010 cross sectional review found that the views of “key opinion leaders” strongly correlate with their sponsor’s interests.2 A 2016 study of 279 000 physicians, using the new US Open Payments transparency initiative (https://www.cms.gov/ openpayments/), found an association between receipt of just one promotional meal and higher prescriptions of the sponsors’ drugs.3 A 2017 Cochrane review has confirmed that sponsored clinical trials tend to find more favourable outcomes about sponsors’ products.4 In 2018 new evidence has identified ongoing sponsor involvement in design conduct and reporting of research, and a lack of transparency around such involvement.5

Other work shows how companies can control information about their products by selectively publishing or suppressing data and even by changing the standards used to evaluate research,6 as described in figure 1. Investigative journalism continues to expose cases where financial interests have contributed to patient harm, as occurred with diabetes drug rosiglitazone,7 with infant formula,8 and with vaginal mesh.9 These examples bear witness to inadequate regulation, aggressive marketing, and a research establishment and medical profession still firmly entangled with industry.

Graphic:

Industry strategies to influence evidence and discourse about evidence

The past decade has seen a growing and related understanding of the threat to human health from overdiagnosis and too much medicine (https://www.bmj.com/too-much-medicine). Recent research confirms the extent to which this medical excess is driven by commercial influences, including on disease definitions.10 By failing to mitigate these influences we overmedicalise society by labelling healthy people as sick, causing unnecessary cost to health systems and harm to patients.

The BMJ’s response so far The 2009 IOM report described transparency as a “critical but limited first step in the process of identifying and responding to conflicts of interest.” It suggested that if medical organisations did not act to reduce conflicts then pressure would likely mount for external regulation. Taking up this challenge, The BMJ has updated its policies around ties with commercial companies (box 1). Box 1: Efforts to increase transparency and independence from. commercial interests at The BMJ

2014: We stopped publishing educational content or clinical editorials from authors who have relevant financial ties to commercial organisations11 2016: We introduced a series of clinical guidelines called BMJ Rapid Recommendations. Here the same policies of independence apply to a large panel, and include additional tougher policies for managing intellectual interests, and involving patients and the public12 2017: We began annual disclosure of all income from industry advertising and sponsorship13 2019: We stopped accepting advertisments for breast milk substitutes following our investigation into its overpromotion for children who do not need them8 These changes show that The BMJ aims not only to describe the, problem but to be part of the solution. They have led to difficult conversations, harder work, increased costs, or loss of revenue. Other organisations will have considered or taken similar steps. We would like to hear about these discussions and reforms, and where possible, outcomes and impact. We also welcome your thoughts on what we should focus on next. The BMJ has also worked with the Centre for Evidence Based Medicine at Oxford University and a global community of evidence based medicine supporters to frame a manifesto for better evidence in medicine.14 One of the manifesto’s nine commitments is to reduce conflicts of interest to facilitate better creation, translation, and use of evidence. Our jointly hosted conference, EBM Live, will include a themed day on conflicts of interest in July 2019. We recognise that taking a strong stance on commercial interests is just one piece of a wider picture of other financial and also non-financial interests. There are many differing perspectives, including from those who question assumptions about the dangers of conflicts of interest.15 By focusing on commercial financial interests we do not aim to minimise or avoid this wider discussion. Call for submissions Today, The BMJ launches a call for submissions for a themed collection (box 2). New transparency initiatives such as US Open Payments provide invaluable data, and we welcome research drawing on these new sources. There are also new and important relationships to study: those with commercial entities beyond drug companies, and those between industry and patient and consumer advocacy groups, which are rightly increasingly influential in the creation and use of evidence.

Box 2: Call for submissions to The BMJ themed collection on commercial interests, transparency, independence Aims of the collection • To better understand the nature of commercial conflicts of interest • To examine how commercial interests effect health and healthcare, including health research, practice, and education • To explore when commercial ties are truly necessary and when independence is most needed • To share examples of progress from transparency to independence What are we looking for? • Submissions for the themed collection are open across all article formats for The BMJ. We seek original data, qualitative and quantitative analysis, as well as evaluated examples of groups or organisations forging genuine independence from industry • We are particularly interested in submissions about industry’s involvement in evidence creation, evaluation, synthesis and translation into guidelines, and about moves towards independence in these processes • We welcome submissions about the interests of commercial organisations producing any products that effect health, including drugs, devices, food, drink, insurance, social media, and information technology • We welcome exploration of ties between industry and all groups relevant to health, including healthcare professional, researchers, and patient or consumer advocacy groups We may offer publication of selected research articles in our sister journal BMJ Open rather than The BMJ, with an online link to the collection.

Submissions are welcome from now, with a final deadline of 15 January 2020. Normal publication processes for each journal will apply. For feedback on ideas before submission please contact hmacdonald@bmj.com

We intend to launch initial material at the Preventing Overdiagnosis conference in Sydney on 5-7 December 2019 (www.preventingoverdiagnosis.net) and the full collection at EBM Live in July 2020 (ebmlive.org). We look forward to receiving your work. We thank Meng Koach for the figure. Competing interests: We have read and understood BMJ policy on declaration of interests and declare the following interests: RM is funded by a National Health and Medical Research Council fellowship, GNT1124207, and hosts a podcast funded by Cochrane Australia. The idea for this collection of content was suggested by RM and adapted in collaboration with the listed authors. FG and HM are editors of The BMJ, which is committed to increasing transparency and ensuring that evidence and practice are independent from financial interests. The BMJ receives income from commercial advertisers and sponsors, declared annually at https:// www.bmj.com/about-bmj/publishing-model. RM has a longstanding interest in conflicts of interest, enhanced transparency, and more independence from commercial interests in healthcare and is cochair of the Preventing Overdiagnosis scientific committee. CH has received expenses and fees for his media work, and he holds grant funding from the NIHR, the NIHR School of Primary Care Research and The NIHR Oxford BRC. CH is Editor in Chief of BMJ Evidence-Based Medicine, an NHS urgent care GP and Director of CEBM, which jointly runs the EvidenceLive Conference with the BMJ and the Overdiagnosis Conference with international partners based on a non-profit model. RM and LB are guest editors of the BMJ themed collection on commercial interests.

Provenance and peer review: Commissioned; not externally peer reviewed. 1 Lo B, Field MJ. Conflict of interest in medical research, education, and practice. National Academies Press, 2009. 2 Wang AT, McCoy CP, Murad MH, Montori VM. Association between industry affiliation and position on cardiovascular risk with rosiglitazone: cross sectional systematic review. BMJ 2010;340:c1344. 10.1136/bmj.c1344 20299696 3 DeJong C, Aguilar T, Tseng CW, Lin GA, Boscardin WJ, Dudley RA. Pharmaceutical industry-sponsored meals and physician prescribing patterns for Medicare beneficiaries. JAMA Intern Med 2016;176:1114-22. 10.1001/jamainternmed.2016.2765 27322350 4 Lundh A, Lexchin J, Mintzes B, Schroll JB, Bero L. Industry sponsorship and research outcome. Cochrane Database Syst Rev 2017;2:MR000033.28207928 5 Rochon PA, Stall NM, Savage RD, Chan AW. Transparency in clinical trial reporting. BMJ 2018;363:k4224. 10.1136/bmj.k4224 30301724 6 Bero L. Ten tips for spotting industry involvement in science policy. Tob Control 2018;28:1-2.29941543 For personal use only: See rights and reprints http://www.bmj.com/permissions Subscribe: http://www.bmj.com/subscribe BMJ 2019;365:l1706 doi: 10.1136/bmj.l1706 (Published 16 April 2019) Page 2 of 3 EDITORIALS BMJ: first published as 10.1136/bmj.l1706 on 16 April 2019. Downloaded from http://www.bmj.com/ on 19 April 2019 by guest. Protected by copyright. 7 Cohen D. Rosiglitazone: what went wrong?BMJ 2010;341:c4848. 10.1136/bmj.c4848 20819889 8 Godlee F. Disentangling ourselves from “big formula.”BMJ 2018;363:k514610.1136/bmj.k5146 . 9 Heneghan C, Aronson JK, Goldacre B, Mahtani KR, Plüddemann A, Onakpoya I. Transvaginal mesh failure: lessons for regulation of implantable devices. BMJ 2017;359:j5515. 10.1136/bmj.j5515 29217786 10 Pathirana T, Clark J, Moynihan R. Mapping the drivers of overdiagnosis to potential solutions. BMJ 2017;358:j3879. 10.1136/bmj.j3879 28814436 11 Chew M, Brizzell C, Abbasi K, Godlee F. Medical journals and industry ties. BMJ 2014;349:g7197. 10.1136/bmj.g7197 25432164 12 Siemieniuk RA, Agoritsas T, Macdonald H, Guyatt GH, Brandt L, Vandvik PO. Introduction to BMJ Rapid Recommendations. BMJ 2016;354:i5191. 10.1136/bmj.i5191 27680768 13 Godlee F, Abbasi K, Bloom T. BMJ declares its revenues from industry. BMJ 2017;359:j4930. 10.1136/bmj.j4930 29070599 14 Heneghan C, Mahtani KR, Goldacre B, Godlee F, Macdonald H, Jarvies D. Evidence based medicine manifesto for better healthcare. BMJ 2017;357:j2973. 10.1136/bmj.j2973 28634227 15 Rosenbaum L. Conflicts of interest: part 1: reconnecting the dots–reinterpreting industry-physician relations. N Engl J Med 2015;372:1860-4. 10.1056/NEJMms1502493 25946288 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/ permissions For personal use only: See rights and reprints http://www.bmj.com/permissions Subscribe: http://www.bmj.com/subscribe BMJ 2019;365:l1706 doi: 10.1136/bmj.l1706 (Published 16 April 2019) Page 3 of 3 EDITORIALS BMJ: first published as 10.1136/bmj.l1706 on 16 April 2019. Downloaded from http://www.bmj.com/ on 19 April 2019 by guest. Protected by copyright.

Commercial interests, transparency, and independence: a call for submissions was originally published on Baby Milk Action

[umonster-altimate-hu3nter]

Monster Hunter 3 Ultimate - Jeu Wii U

49€99

Les points forts :

Plateforme : Wii U

Edition : Ultimate

Genre du jeu vidéo : Action, Jeu de rôle

Date de sortie marché : 22 Mars 2013

Editeur : Capcom

PEGI - Public : 12+

Informations générales sur le produit Marque NINTENDO Nom du produit Monster Hunter 3 Ultimate - Jeu Wii U Catégorie JEUX WII U Informations Générales Titre du jeu Monster Hunter 3 Ultimate Titre alternatif Monster Hunter 3 Ultimate Plateforme Wii U Date de sortie marché 22 Mars 2013 Edition Ultimate Editeur Capcom Studio de développementCapcom LicencesMonster Hunter Support du produitDisque Wii U Description du produitPrenez les armes et aventurez-vous dans un monde aux environnements spectaculaires peuplés de monstres redoutables dans Monster Hunter 3 Ultimate sur Wii U. Avec des monstres, des armes et des équipements inédits et plus de 200 quêtes pleines d'action à entreprendre, Monster Hunter 3 Ultimate est l'opus le plus complet de la série à ce jour. Dans ce RPG d'action, la satisfaction d'avoir remporté des combats difficiles ne sera pas votre seule récompense : découpez les monstres vaincus pour obtenir leurs os, leurs cornes, leur peau et autres puis transformez-les en armes et armures pour vous préparer aux batailles encore plus difficiles qui vous attendent. Telle est la voie du chasseur. Grâce aux fonctionnalités uniques de la Wii U, Monster Hunter 3 Ultimate offre aux joueurs une expérience de chasse vraiment intuitive. La nouvelle caméra de visée en option permet de cibler plus facilement les monstres proches d'une simple pression sur un bouton. En cours de jeu, accédez rapidement aux livres, armes, cartes de terrain et mini-jeux avec l'écran tactile du Wii U GamePad et explorez l'univers unique et époustouflant du jeu grâce au rendu graphique de grande qualité de la Wii U. Constituez des équipes allant jusqu'à 4 joueurs en ligne ou partagez la traque avec des joueurs sur Nintendo 3DS grâce à la communication sans fil locale. Si vous possédez à la fois une Wii U et une Nintendo 3DS, ainsi qu'un exemplaire de Monster Hunter 3 Ultimate pour chaque console, profitez de la compatibilité des sauvegardes pour emporter partout la chasse commencée chez vous. Plus produit- Dans ce RPG bourré d'action, chassez de nouveaux monstres redoutables et lancez-vous dans plus de 200 quêtes épiques - Faites équipe en ligne avec d'autres détenteurs d'une Wii U ou utilisez la communication sans fil locale pour jouer avec les - Transférez votre sauvegarde sur Monster Hunter 3 Ultimate pour Nintendo 3DS afin de continuer la chasse où que vous alliez Style de Jeu Genre du jeu vidéoAction Jeu de rôle PEGI - Public12+ PEGI - ClassificationViolence Online Game Langues des menusFrançais Langues du manuelFrançais Compatibilité Mode réseau Non Mode en ligne Non

[garfieldsource]

[sinfonia-relativa]

"Respirar profundo, calma por un momento y tormenta todo el tiempo."

Sad_Boy☕

[sinfonia-relativa]

Si estoy o no...

En más de una ocasión me he preguntado, ¿Me extrañarían? La respuesta para mí mismo siempre ha sido un rotundo "NO" ya que me he desconectado en varias ocasiones, si estoy o no, da lo mismo saben... es una lucha constante entre mi demonio y yo, no me animo a responder mensajes, no quiero responder llamadas, quisiera tener la fuerza para desconectarme de todo por completo y escapar, ver que tanto resisto hundido en el hoyo donde me ahogan mi demonio junto a la evidente depresión.

Sad_Boy☕

[sinfonia-relativa]

Frente a todo el enredo que persiste en mí cabeza, quiero creer que algo bueno he llegado a hacer o por lo menos he dicho, tengo una lucha que no acaba y el simple hecho de continuar es valiente ante mi inevitable soledad, buscada o no... Duele.

Sad_Boy☕

[sinfonia-relativa]

"Le diste un hogar y te agradezco, pero yo continuo siendo un completo extraño en aquellos terrenos... No pertenezco."

Sad_Boy☕

[sinfonia-relativa]

Aún me impresiona cómo mantengo la sonrisa... Cuando sólo quiero llorar.

Sad_Boy☕

[sinfonia-relativa]

"Me tropiezo, mi cuerpo esta lleno de heridas y la mirada aunque apagada, siempre tiene la opción de continuar así sea gateando para avanzar aunque el dolor no lo suelte jamás"

Sad_Boy☕

[desorden-en-letras]

Tengo educación, simplemente no tengo paciencia. Si alguien me golpea el corazón, simplemente me levanto y me voy, no tengo por que aguantar a las personas que no amo.

Caio Augusto Leite

[desorden-en-letras]

[garfieldsource]

MTV Movie Awards, 2012