#symptomsofmalaria

[medeazhealth]

Symptoms of Malaria: It can be defined as a disease caused by mosquito parasite which gets into our bodies through the bite of an infected female anopheles #mosquito. . . . . . Visit: https://www.medeaz.com/ Whatsapp Us: https://bit.ly/2YmaSdM For More Details, contact us:☎ 91 6305827170

[chromoscience]

Research Highlights: Cutting the Energy Source of the Malaria Parasite Plasmodium

Malaria parasites (purple) infect hosts’ red blood cells (pink, with mouse cells shown). JOSEPH TAKAHASHI LAB/UT SOUTHWESTERN MEDICAL CENTER/HHMI Original Authors: Xin Jiang, Yafei Yuan, Jian Huang, Shuo Zhang, Shuchen Luo, Nan Wang, Debing Pu, Na Zhao, Qingxuan Tang, Kunio Hirata, Xikang Yang, Yaqing Jiao, Tomoyo Sakata-Kato, Jia-Wei Wu, Chuangye Yan, Nobutaka Kato, Hang Yin, Nieng Yan Malaria is a mosquito-borne disease caused by a parasite. People with malaria often experience fever, chills, and flu-like illness. Malaria is caused by single-celled microorganisms of the Plasmodium group. Plasmodium species rely on glucose for energy supply during blood stage. Cutting the glucose uptake is a potential strategy for the development of antimalarial drugs. Plasmodium has a protein that transports glucose, and this protein is known to be essential for parasite growth and survival. In another study, compound 3361 (C3361) has been described to moderately inhibits this glucose transporter protein and suppresses the growth of the blood-stage parasites. This study present the crystal structures of the glucose transporter protein in complex with D-glucose and with the selective inhibitor C3361. Although both structures were blocked, binding of C3361 causes marked rearrangements that result in an additional pocket. This inhibitor-binding-induced pocket presents an opportunity for the rational design of the glucose transporter protein inhibitors. Read the full article