#tnf 1982

[peekone]

The North Face, 1982 (SS Catalogue)

[drlaurynlax]

Thyroid Medication Does Not Always Work: 6 Reasons You Need to Know

When it comes to thyroid medication, there is no one-size-fits-all answer.

Medication is often viewed as the “panacea” in conventional healthcare.

Headache? Pop an Advil.

High blood pressure? Take a statin.

Unwanted weight gain, fatigue or swelling?

Thyroid medication to the rescue.

Thyroid medication, specifically levothyroxine (Levothyroid® Synthroid®, Levoxyl®, and Armour®),  are the most prescribed drugs in the nation—ranking above statins, SSRI’s and the birth control pill. Since many conventional practitioners do not typically consider the different variations of thyroid disease (i.e. Overt vs. Subclinical vs. Secondary vs. Autoimmune), any sign of an “off” thyroid marker must mean you need a replacement.

In theory, this sounds good—especially if you are feeling the effects of a thyroid condition. If you have a thyroid issue, you can’t wait to start taking your thyroid medication to make the dreadful symptoms go away – good bye constant fatigue, brain fog, stubborn weight gain, headaches, sleepless nights, depressed moods, and so on.

However, what happens if you take your medication and still don’t feel any better? Even when blood tests (TSH & TH) suggest that thyroid function is “back to normal,” many individuals still feel like they did prior to the medication.

Unfortunately, thyroid formulas are not always the panacea they are made out to be, often yielding mixed or subpar results for some—especially if you’re not on the right formula for you.

Here are 6 reasons your thyroid medications may not work:

1. You’re Not Absorbing the Thyroxine Hormone in the Medicine

Simply put, if you have a gut or liver issue, your body will not metabolize the thyroid medication properly.

2. You’re Overdiagnosed or Overtreating a Thyroid Problem

Your thyroid may not be the issue. Common culprits behind “thyroid symptoms” include:

Underlying gut pathologies (bacterial overgrowth, low stomach acid, parasitic infection, bacterial infection, H. pylori)

Chronic stress & HPA Axis Dysfunction (adrenal, cortisol and hormone imbalances)

Underfunctioning pituitary (controls the growth, development and function of other endocrine glands)

Environmental toxic burden

Low immune function

Reduced oxygen to cells (iron deficiency or in some cases, iron overload)

Blood sugar imbalances

Other chronic diseases, inflammation or underlying infections (Lyme disease, hepatitis C, IBD, etc.)

Long-term medication use or drug-induced hypothyroidism (overdose of thyroid hormones or other hormones)

Nutrient deficiencies (selenium, copper, iodine, zinc, pyridoxal 5 phosphate, zinc, magnesium)

3. You Have a T4—>T3 Conversion Problem (Not a Thyroid Problem)

Your cells must be able to convert T4 to T3, the active form of thyroid hormone, in order to produce energy. If they can’t make the conversion, you may still experience thyroid symptoms while on the medication. What causes poor conversion? Inflammation! Inflammation decreases the conversion of T4 to T3. T4 is the inactive form of thyroid hormone. Furthermore, the body has to convert it to the active T3 form before it can be used. Most synthetic hormone medications on the market are T4. If you give a T4 medication (like Synthroid, Levoxyl, Unithroid, etc.) to a person with inflammation already, it’s not going to work because they can’t convert the T4 to T3.

On bloodwork, a red flag that you’re having conversion issues is having low levels of T3 with normal T4 and either low or normal TSH—also known as “low T3 syndrome”. Although it does involve low levels of T3 (the most active form of thyroid hormone), it is not caused by a problem with the thyroid gland.

Low T3 Syndrome is a byproduct of the following “inflammatory” issues:

Chronic stress (HPA Axis Dysregulaton) and increase in inflammatory markers (particularly inflammatory cytokine TNF-alpha)

Under-active pituitary function (your pituitary cannot produce thyrotropin to then produce T4 and T3)

Gut or liver issues (20% of your active thyroid hormone (T3) is converted in your gut and the remaining 80% is converted by other organs, especially the liver, brain, skeletal muscle and kidneys)

Alterations in the carrier proteins that transport T4 and T3 hormones throughout your body (due to stress or nutrient deficiencies)

Changes in YOUR thyroid hormone receptors (THR)—inhibiting or over consuming thyroid hormones

4. You Have Autoimmune Thyroid

Hashimoto’s and Grave’s disease are inflammatory conditions wherein the thyroid attacks itself. The top twos driver of autoimmunity are intestinal permeability (“leaky gut”) and triggers (inflammation) that “turn on” the genes of autoimmunity—not poor thyroid function.

If you’re taking a thyroid medication for a condition—particularly if you have an undiagnosed autoimmune condition—but you’re not addressing your gut health, inflammation and personal triggers (from fluoride in your water and toothpaste, to birth control pill use, antibiotic history, mold in your home, etc.) then medicine won’t do a body good.

5. You’re Medications are Contraindicated

Interestingly, many medications—or supplements for that matter—produce drug interactions with thyroid  medication. For instance, estrogen found in birth control pills can exacerbate thyroid dysfunction. Even slight alterations in the dosing or absorption of medications can impact the effect of thyroid hormones. Additionally, do your research on what you are currently taking to uncover for yourself how medications may affect the assimilation or absorption of thyroid hormones.

Beyond interactions as well, medications for other health conditions may have a direct effect on the health of your thyroid in other ways—destroying thyroid cells and tissue, impacting natural thyroid hormone production and triggering the immune processes of the thyroid gland.

According to pharmacist Isabella Wentz, the top 9 drugs and chemicals that may affect thyroid function include:

Lithium (SSRI for bipolar, depression)

Amiodarone (heart disease)

Fluoride (toothpaste, water)

Hormone Replacement or Birth Control

Proton Pump Inhibitors (PPI’s for acide reflux)

Interferon (cancer drug)

Accutane (skin conditions)

Iodine (contraindicated if you have a selenium deficiency or you do not have a true iodine deficiency)

Botox (plastic surgery)

Also, if medical reasons warrant your thyroid medication use, it is even more important to optimize essential nutrients including probiotics and prebiotics, magnesium, zinc, B-vitamins and glutathione.

6. You’re Taking the Wrong Dose or Type of Medicine for You

The strength and power of your thyroid changes over time—it fluctuates with the change of seasons, it gets weaker as you age, and it increases or decreases hormone production as you gain or lose weight or if you are under more stress than usual. However, when we take medication, it works in contrast. We do not modify thyroid medication immediately as we change our weight, as the seasons change or anything else happens to our body. As a result, you can have a mismatch between the medication dose you were prescribed and what your body currently needs.

In addition, unlike supplemental herbs and natural compounds, many medications are “synthetic” (fake)—leaving you feeling less than natural.

A blinded study comparing the effects of natural desiccated thyroid hormone (T4/T3) vs. levothyroxine (synthetic T4) found that the patients who took the more natural version felt better—despite normal blood work results on both trials. In the study, a total of 70 patients with hypothyroidism were treated with either desiccated thyroid extract or levothyroxine for 12 weeks followed by a switch to other option for another 16 weeks. The participants were “blinded” during both phases—they did not know the type of pill they received. After each treatment period patients were weighed, had blood tests, underwent psychometric testing and were asked which therapy they preferred.

The researchers reported that 49% of the patients preferred desiccated thyroid extract, 19% preferred levothyroxine and 23% had no preference. Desiccated thyroid extract use was also associated with more weight loss. There was no difference in the psychometric testing or in any symptoms. Lastly, both types of thyroid hormone were able to normalize the abnormal thyroid blood tests. Although desiccated thyroid extract is not widely used, this study showed that many patients preferred the more natural option as compared with levothyroxine, potentially worth considering with your healthcare provider if your symptoms are not improving on thyroid medication (1).

References:

Hoang TD et al Desiccated thyroid extract compared with levothyroxine in the treatment of hypothyroidism: A randomized, double-blind, crossover study. J Clin Endo- crinol Metab 2013;98:1982-90. Epub March 28, 2013.

  The post Thyroid Medication Does Not Always Work: 6 Reasons You Need to Know appeared first on Meet Dr. Lauryn.

Source/Repost=> https://drlauryn.com/wellness-knowledge/thyroid-medication-does-not-always-work/ ** Dr. Lauryn Lax __Nutrition. Therapy. Functional Medicine ** https://drlauryn.com/

[ecoorganic]

Mailbag: Future Changes to NFL's TV Packages, Impact of Canceled College Games

Plus, the impact a canceled college season has on the NFL, what to expect from Gardner Minshew in Year 2, whether this season will be seen as legitimate and more.

It’s a sad day in the football world. Blue-blood programs that are 41 (Michigan), 33 (Penn State), 32 (USC) and 30 (Ohio State and Nebraska) years older than the NFL itself won’t be playing this fall. And no matter who you blame, it’s a shame that

we’re here.

The slow death march college football seems to be on will absolute reverberate in the NFL world. We’re going to get to that, and a whole lot more, in this week’s mailbag. …

From Brock Ascher (@BrockAscher): What happens to NFL TV rights in the near future? Will I ever be able to get rid of DirecTV? Will I ever be able to buy a one-team out of market package?

Brock, my guess is the over-the-air packages will probably remain the same. I think Thursday night is the one variable in all this, with the potential Disney snaps it up so it can put either MNF or TNF on ABC, with the other staying on ESPN, ideal for them for cable-fee reasons. (My guess is Fox is finished with TNF.) The biggest difference you’d notice could come in structure. I was told by two execs that the NFL has discussed jettisoning the divvying up of Sunday afternoons by conference (the cross-flex would be a precursor to that).

It’d give the NFL more flexibility and, in this scenario, you could have Fox and CBS simply split up the games, via some sort of “draft.”

After that, we can dive into how streaming (where the younger audience lives) plays into all of this, and how the Sunday Ticket package you’re referencing factors into that. AT&T now owns DirecTV, which has the Ticket through 2022. The Ticket is vital to DirecTV's survival. How much does AT&T care about that? We’ll see, because the NFL has discussed the idea of moving the Ticket to a streaming service, where a younger audience lives.

You can imagine what the Ticket would be worth to ESPN-Plus, Peacock, HBO Max, DAZN or Amazon Prime. How many people would jump on those services if the Ticket was there? Based on DirecTV’s numbers, the answer is a lot. And part of the NFL’s concern about production quality in doing something like this may have been alleviated with how smoothly Amazon Prime’s venture into creating such a product for the Premier League over in the UK went.

As for the a la carte end of this, we’ll see. I think that’s coming, but it might be further down the line, and whoever were to win the Ticket rights would be involved in all of that. The bottom line here: Media’s changing fast, and the NFL is preparing for that.

From Jonathan Barakat (@jonathanbarakat): How do you think Gardner Minshew will play this year? Will he exceed expectations? Also what do you think of D.J. Chark coming into his third year?

Jonathan, I’ll give you what I like and what I don’t like about Gardner Minshew’s situation.

What I like: Minshew gets to play for Jay Gruden, who’s immediately made a big difference for young quarterbacks in both his previous NFL homes (Kirk Cousins in D.C. and Andy Dalton in Cincinnati), and in one of those cases actually did it with a rookie coming off the lockout, which is somewhat analogous to this situation. Also, D.J. Chark gives Minshew a strong No. 1 target, and Doug Marrone will use the run game to support him.

What I don’t like: It’s pretty clear where Jacksonville stands on Cam Robinson, and having an issue at left tackle isn’t great—particularly in a year when it’s going to be tough to work out offensive line issues on the fly. Also, the viability of the run game rides largely on Leonard Fournette, who hasn’t been the most reliable guy over his first three NFL seasons. And beyond Chark, there are question marks at receiver and tight end.

So all in all, it’s not a complete mess, but not really setup for Minshew to have a breakthrough sophomore campaign.

From Roberta Wears A Mask You Should Too (@AceandJasper): How will the teams take care of season ticket holders who won't get to sit in their front row seats even for a game or two?

Most teams are rolling payments over or refunding—and I can’t imagine any haven’t already given their season-ticket holders the choice to opt out and hold on to the rights to their seats in 2021. I think, at this point, we know that the season isn’t going to start with full stadiums anywhere. How will it end? That’s four months from now. And I think the last four months should be enough to keep anyone from making predictions that far ahead.

From Erik Ghirarduzzi (@eghirarduzzi): Given the circumstance around this season, currently known and ones yet to come, how legit would a SB winner be? There are teams at a competitive disadvantage, through no fault of their own, already and the season hasn't started.

Erik, this is a great question—I do believe this year will be remembered, if it’s completed, like the strike years of 1982 and ’87. In ’82, teams played nine games, the divisions were temporarily abolished, and a 16-team playoff was staged. In ’87, just six quarterbacks broke 3,000 yards passing, and just two backs reached 1,000 yards rushing. In both years, interestingly enough, Joe Gibbs led Washington to a championship.

Now, I don’t think the season necessarily will be cut to nine games (as ’82 was), nor will you have the oddity of replacement players en masse (like ’87 had). But I do think there’ll be aspects of the season that will go sideways, and the NFL, to its credit, knows it and is preparing for that.

So how are ’82 and ’87 remembered? I think most people who didn’t live it (I was way too young, 2, to remember the former, and have faint memories of the latter) probably wouldn’t look at championships or accolades from that year (John Elway was MVP and Reggie White DPOY in ’87) much differently. But it doesn’t take much Google acumen to discover how weird all the numbers from those seasons look.

To me, that feels like the likely result of this year.

From Dan Heiserman (@HeisermanDan): Has any player in history ever been on more teams than Josh McCown?

Speaking of Google, Dan, I didn’t know the answer to this and was legitimately interested, so I looked and found that legend-of-the-aughts J.T. O’Sullivan was on 11 (!) different NFL teams (Saints, Packers, Bears, Vikings, Patriots, Panthers, Lions, Niners, Bengals, Chargers, Raiders), which unbelievably matches McCown’s number (Cardinals, Lions, Raiders, Dolphins, Panthers, Niners, Bears, Bucs, Browns, Jets, Eagles).

A little more bumping around the internet showed that kicker Bill Cundiff was, at one point or another, with 13 different NFL teams (Cowboys, Bucs, Packers, Saints, Falcons, Chiefs, Lions, Browns, Ravens, Washington, Niners, Jets, Bills). And I’m sure there are other backup quarterbacks and kickers—playing positions where careers are longer, which facilitates this sort of movement—out there like these guys.

All of them must have pretty cool jersey displays in their basements.

From SUPER BOWL SUPER BROWNS HELL YEAH!!! (@WAH3rd): Should I still go back to the party barn and start drinking at 7 a.m. and yell at people on Saturdays this fall like I used to?

This is a very specific message just for me and a lot of other people who were in legit mourning on Tuesday night—and this will be absolutely be one of the Lane Avenue casualties (right there with the Varsity Club) of the depressing news we all got. It’s hard to describe the Party Barn if you don’t know what it is already, so I won’t try.

And the answer is yes.

From Skeeter6265 (@skeeter6265): Do you think Ohio will beat Michigan?

I was very excited for Michigan to celebrate the 20th anniversary of its last win in Columbus—that was in the fall of my junior year—this November. Maybe that team can have a Zoom reunion to commemorate it now.

From FootballFan64 (@FFan64): With college coaches out of the running for NFL openings since their season is moving to the spring, which NFL coordinators do you expect to be coveted for any newly vacated HC positions? Who is this year’s Matt Rhule?

Well, Football Fan, I’m not sure that colleges playing in the spring (if that even happens) would prevent NFL teams from making runs at coaches at that level. If, and again it’s a big if, college football goes in the spring semester, my guess would be the season would start in February (you can’t just start the season the minute kids get back to campus). The NFL coaching carousel is spinning at the beginning of January. So there’d be time.

The NFL coordinator names you’ll hear most are some of the usual suspects from the last couple cycles—Patriots OC Josh McDaniels, Chiefs OC Eric Bieniemy, Ravens coordinators Greg Roman and Wink Martindale, 49ers DC Robert Saleh and Saints DC Dennis Allen would be on that list. I’d also just keep an eye on Falcons DC Raheem Morris, Chiefs pass-game coordinator Mike Kafka and Titans OC Arthur Smith as names that could pop up.

As for the next Matt Rhule, the NFL will continue to have interest in Oklahoma’s Lincoln Riley, and Ohio State’s Ryan Day is beginning to be held in that sort of regard among those in the pros. But both those guys have jobs that are very well-paying and, in reality, better than the majority of jobs they’d find in the NFL. Stanford’s David Shaw and Northwestern’s Pat Fitzgerald have long been on the radar of the league, but haven’t shown much appetite for leaving their alma maters. And Minnesota’s P.J. Fleck is a fun name to keep an eye on.

From Shawn Tangen (@SMTangen): How is Kevin Warren viewed within NFL circles?

Shawn, I’d say it’s pretty mixed. And I got some pretty strong reaction from certain corners of the NFL about the Big Ten commissioner (and former Vikings executive) after the conference canceled its season on Tuesday.

Warren was a polarizing figure inside the Minnesota locker room during the Adrian Peterson scandal of 2014—Peterson felt like Warren betrayed him to the point where Warren’s promotion to COO was a sticking point in the star’s contract negotiation. That was a situation that coach Mike Zimmer had to manage, and ultimately defuse, on the ground with the players, and it’s just one example in his NFL past where he’s rankled co-workers.

On top of that, many NFL people felt like Warren’s move to the Big 10 was with designs on eventually making a run at becoming NFL commissioner down the line. In that regard, the final result of his management of the last week (a result we won’t have for a while) will probably go a long way in determining whether those aspirations are realistic or not. I’d just hope his decisions here weren’t made with that in mind.

From Brycen Papp (@BrycenPapp): Do you think this season will be a massive shift in the way the draft process works? Will the NFL lower the requirements for college players to be draft eligible to two years instead of three?

Brycen, I think there will be a shift to the draft process to a degree, and we’re going to get into that in the GamePlan on Thursday. But I do want to get into your question on the NFL’s age requirement, because it’s a fascinating one—and something we covered extensively on the podcast this week.

I believe many of the best players in the Big 10 and Pac-12, from places like Ohio State, Oregon, USC, Penn State and Michigan, will sign with agents now, and go into draft prep. Because of that, and how the Big 10/Pac-12 shutdown devalues this college season, I think we’ll also see some attrition from the other conferences. That could lead to some players who only played two years of college football and skipped the required third year out of high school, going high in next April’s draft.

That, in turn, could open the door in the future for players with two good years on their resume skipping their junior year to protect themselves and prepare for the draft—in the same way Christian McCaffrey skipping his bowl game in 2016 gave others cover to do the same. At that point, the idea that players need three years of development to be NFL-ready gets broken down, and now you have guys taking a “gap year” instead.

Which isn’t good for the players, for college football or for the NFL.

It’s important to remember here too that it’s not college football keeping guys in school for three years. It’s pro football. The three-year rule is an NFL rule. And when Maurice Clarett and Mike Williams sued to become eligible for the draft in 2004, it wasn’t a school, a conference or the NCAA they sued. It was the NFL. So the ball would be in the NFL’s court on this one, if the situation comes to a head.

From Sam Perrone (@samjp33): Do you think the NFL would be willing to move the draft if the college football season bleeds into the spring?

I think, Sam, the NFL will do whatever it needs to in order to support the golden goose that is college football. Why? College football is very good for the NFL. And primarily for three reasons.

1) It’s a free minor league. The NFL, unlike the other sports, doesn’t have to fund a complex minor-league system to develop college-aged players. The expense of doing so in a sport like football would be astronomical and the opportunity to monetize it, as we’ve seen with other start-up leagues in the past, would be pretty limited.

2) It’s a marketing monster for star players coming in. Say what you will about Tim Tebow and Johnny Manziel—they were legit sports-world celebrities before they lifted a single dumbbell in preparation for the draft. Everyone knows who Joe Burrow, Tua Tagovialoa and Chase Young are. Ezekiel Elliott and Saquon Barkley were household names as collegians. And all of that is great for the NFL on so many different levels.

3) College football is the foundation for the NFL’s tentpole offseason event. The draft is The Draft because of college football. We’ve been watching most of the top players for years. It marries two wildly popular entertainment entities. The draft itself wouldn’t be nearly the event it is without college football.

So, in order to protect the sanctity of a spring college football season (as much of a sham as it might be) would the NFL be willing to move the draft back a few weeks? Well, of course it would be.

• Question or comment? Email us.

from Blogger https://ift.tt/3fO2YCN

[kadobeclothing]

The Biggest Style Moments Of 2019

As years go, 2019 has been a turbulent one. We witnessed the devastating consequences of climate change in the Amazon rainforest; we waited in quiet amusement as Cheeto-fingered neckbeards openly conspired to storm Area 51; we saw the first-ever image of an actual black hole, and subsequently hoped it would come to swallow us up whenever politics was on the news.With another Black Mirror-esque headline hitting the news daily, keeping abreast of the latest and greatest in fashion wasn’t easy. Those who managed, however, will know that the year in menswear proved to be an equally wild ride. Sustainability made its way into haute couture’s upper echelons, legends died (RIP Karl Lagerfeld), new ones were born and (for some unfathomable reason) everyone had their nipples out.With 2020 just around the corner, it’s time to reflect on the best menswear moments from the last 12 months. From the designers rewriting the rules to the trends worth taking with you into the new year, here we hand out the awards for services to men’s style in 2019.Most Influential DesignerChristopher RaeburnIn under a decade, Christopher Raeburn has gone from largely-unheard-of freelance pattern cutter to world-renowned sartorial innovator, global creative director of Timberland and leading figure of sustainability in high fashion. His “remake, recycle, reduce” mantra may sound like just another marketing ploy, but believe us when we say that this is a man who truly does practice what he preaches.For those unfamiliar with the British designer’s work, this year’s collaboration with The North Face is a prime example of what he does best. Using cuttings from old TNF tents, Raeburn created a line of upcycled, co-branded luggage, each bag custom made and completely unique.It’s a new way of looking at the way in which we consume fashion – reimagining the things we already have, rather than mindlessly buying more – and something we’re sure to be seeing a lot more of as a direct result of Raeburn’s work.Menswear IconTimothée ChalametHot-pink tailoring, a sequin-encrusted chest rig, paint-splattered overalls and even a bowl haircut thrown in for good measure. On paper, Timothée Chalamet’s recent style and grooming choices don’t sound like those of one of 2019’s best dressers, but look at the way he carries it off and you’ll understand.For some time now, The King star has been helping to redefine and reinvent modern menswear, but it was during this past year that he established himself as one of the key players. Mixing sharp suiting with intricate embroidery, lavish detailing and plenty of colour, there’s rarely been a dull moment when this guy is trotting the red carpet.Granted, not all of us have the plums necessary to wear an all-over floral-print two-piece and low V-neck to our next formal occasion. Still, where injecting some personality into proceedings is concerned, we can all stand to learn a lot from this Beautiful Boy.Most Wearable Brand Of The YearReissIn a retail world hellbent on delivering the latest trends as quickly as possible (at the expense of both the environment and your future self’s ego – thanks, Facebook Memories), Reiss might just be the last bastion of good taste and quality on the high street.Infinitely reliable, eternally stylish and, while it may be at the upper end of some budgets, capable of producing garments that will last years as opposed to a single season. We’re not the only ones that think so either because in 2019, Ryan Gosling, Tom Holland and Stormzy have all been showing the British label some love.For timeless designs, flattering cuts and all-round versatility, there’s currently no other brand delivering the goods to this standard at this price point, and you can bet 2020 will be much the same.Style Move Of The YearLoosening UpThe year 2019 may have spelt bad news for democracy, the climate and Prince Andrew’s publicist, but was great for our collective circulation. This was the year when skinny fits slimmed down so much that they disappeared entirely, and you no longer had to be a roll-up-smoking skater in a tiny beanie in order to rock a pair of wide-leg trousers.Baggy pants, wraparound tailoring, boxy shirting and relaxed outerwear; 2019 marked the general loosening up of menswear in the mainstream. Slim-fit is still around, but it’s slowly giving way to a more laid-back look, ushering in a new age in men’s stylePerhaps it’s the latest mutation of the overarching ’90s trend that has been dominating wardrobes for the last couple of years, or maybe men are just sick and tired of wasting five minutes wrestling with their jeans on every morning. Either way, it’s here and it’s not going away, so peel off those drainpipes one last time and give yourself some room to breathe.Trainer Of The YearNew Balance 990V5“Worn by supermodels in London and dads in Ohio,” read New Balance’s 2019 ad campaign for the latest sneaker in its much-loved 990 series. And now, as it turns out, basically everyone else, too.There was no shortage of high-profile trainer releases in 2019 – the Nike x Sacai LDWaffle, the Air ‘Diordan’ and the Adidas LG Spezial to name a few – but in terms of mass appeal, nothing rivalled the success of the 990V5.The fifth incarnation of the first-ever $100 sneaker, originally released back in 1982, the latest 990 is still something of a status symbol, albeit a very, very comfortable one. To look at, it’s not much. Plain, grey, suede and mesh construction; it’s not exactly crying out for attention, but therein lies its beauty. This is a blank canvas of a shoe; a Stan Smith for the dad-shoe generation.Worst TrendNipplesWe almost can’t believe we’re having to say this, but your nipples are not – repeat, not – the latest must-have fashion accessory. To be fair, you probably already knew that, but some of the world’s leading fashion houses and A-list celebs giving areolas a wholly undeserved amount of airtime obviously didn’t get the memo.Sheer tops, shirtless tailoring and just straight-up bare chests were everywhere in 2019. Even style icons like Donald Glover were at it, while several designers built whole collections around suits worn bare-chested.Look, if you’re on the beach or relaxing in the comfort of your own home, fine. Take your shirt off and be at ease. Any other time, put them away, because no Tinder date in their right mind wants to sit across from you at a restaurant trying to eat a pepperoni pizza while your own slices of salami peek out from behind your jacket’s lapels. Just put your tits away, for the love of God.Luxury Brand Of The YearDiorOur favourite Dior moment of the last five years has to be when Johnny Depp’s ‘Sauvage’ campaign posters were being defaced so that they read ‘Sausage’ instead. Narrow it down to the last two years, however, and we’d have to say Kim Jones taking the helm as creative director of Dior Man.Virgil Abloh is often credited with being the man who brought streetwear to the runway, but it’s Jones who made the first real leap. During his time at Louis Vuitton, it was the British designer who masterminded the infamous Supreme collaboration that sent shockwaves through the fashion world. Now, as the creative force behind Dior’s menswear arm, he’s bringing one of the world’s most historic labels back up to speed.This past year, Dior became relevant again. Yes, there were some bare chests with tailoring, but there were also unprecedented hookups with streetwear legends like KAWS and Shawn Stussy. Jones may have set up the blind date between high fashion and streetwear at LV, but this year at Dior he cemented it as a marriage made in heaven.Best CollaborationAimé Leon Dore x Drake’sSome things were just made to go together. Strawberries and cream, Bogart and Bacall, beer and karaoke, and, as it would happen, the colourful preppy, streetwear stylings of Aimé Leon Dore and the off-beat, oversized tailoring of Drake’s.This year’s hottest collaboration was a tale of two cities. On the one side, London’s very own Drake’s: a quirky tailoring and upscale casualwear brand at the cutting edge of the Big Smoke’s menswear scene. On the other, Aimé Leon Dore: the vibrant streetwear label helmed by scene figure Teddy Santis that has had fashion editors’ tongues wagging since it burst into our lives in a flurry of colour back in 2014.The resulting collection saw ALD reimagine classic Drake’s staples – think unstructured blazers, ties, pleated trousers – and infusing them with a hearty dose of colour, with the odd pair of joggers thrown in for good measure. A masterclass in trans-Atlantic relations.Best Hair TrendHigh & TightAfter several years of messy mops, shoulder-length locks and tousled trims, it was only a matter of time before the pendulum began to swing in the opposite direction. The return of close crops and shaved sides was 2019s biggest tonsorial shift, and with everyone from Ryan Reynolds to the king of hair trends David Beckham getting on board, you can be sure this is a sight of shorter things to come.The high and tight is the perfect chop for such a busy year. Yes, it looks good, but it’s also a breeze to style, affording even the busiest of men a valuable extra 10-to-15 minutes of pillow time in the morning.Aside from that, it’s one of the few hairstyle comebacks of recent years that even your nana would like; a far cry from curtains, bowl cuts and whatever that thing was where everyone was dying their hair pink. Smart, sensible and fuss-free.Biggest ComebackSocksIt’s difficult to determine what will be remembered as the major trends of a decade without the benefit of at least a few years’ hindsight. Still, if we had to put money on it, we’d say that 2010 to 2020 will largely be looked back upon as an era of exposed ankles and sneaker liners.Proper socks have served society well since the 8th century, but at some point in the last 10 years, men decided we were too good for them. Instead, we opted for ridiculously small ones that left our lower legs exposed to the elements and ourselves open to looking ridiculous whenever we had to take our shoes off at someone else’s house.This year, however, the tides began to change. Socks crept back up our calves, reminding us all what we’d been missing for so long. From extortionately priced Balenciaga tube socks to classic Nike 3-packs, virtually no ankle was left uncovered. Hey, we all thought we looked cool at the time, but then so did everyone strutting around Carnaby Street in their flares in the ’70s.Most Wearable TrendThe Great OutdoorsGore-Tex hardshell, trail runners, hiking boots, fleece jacket, detachable Vibram soles: it might look like a mountaineer’s packing list, but this is actually a rundown of some of the hottest streetwear items from the last 12 months. This was officially the year that functionality went fashion, and if you live somewhere with a climate as wildly unpredictable as the UK, that’s never going to be a bad thing.The Japanese have known it for a long time, but the rest of the world has finally caught up on the fact that this kind of clobber, when done right, not only looks good but also makes life that little bit more comfortable.Many of 2019’s most talked-about designers weren’t actually fashion labels at all, but outdoor brands with crossover appeal. Salomon, Hoka One One, Patagonia, Arc’teryx and beyond; the sort of gear that wouldn’t look out of place at a Fashion Week show, but also that your dad might ask to borrow.Watch Trend Of The YearMilitaryIn a year obsessed with functionality and utilitarian design, it should come as no shock that 2019’s defining watch trend was something highly practical. Military timepieces came back in force over the course of the last 12 months, giving many men pause for thought when it came to their everyday tickers.Simple, rugged and stylish, their reemergence offered up a fresh alternative to divers and chronographs when it came to picking a timepiece for day-to-day dealings. Whether it was a simple NATO-strap field watch from Timex, or a heritage reissue from Longines, these armed-forces veterans where everywhere.As far as trends go, this is one that’s well worth investing in: versatile in terms of styling but also built for the battlefield when it comes to construction. Plus, if you put your money into one of the limited pieces, there’s a good chance you could have a collector’s item on your wrist in a few years time. Source link

source https://www.kadobeclothing.store/the-biggest-style-moments-of-2019/

[elizabethbgrimes]

Thyroid Medication Does Not Always Work: 6 Reasons You Need to Know

When it comes to thyroid medication, there is no one-size-fits-all answer.

Medication is often viewed as the “panacea” in conventional healthcare.

Headache? Pop an Advil.

High blood pressure? Take a statin.

Unwanted weight gain, fatigue or swelling?

Thyroid medication to the rescue.

Thyroid medication, specifically levothyroxine (Levothyroid® Synthroid®, Levoxyl®, and Armour®),  are the most prescribed drugs in the nation—ranking above statins, SSRI’s and the birth control pill. Since many conventional practitioners do not typically consider the different variations of thyroid disease (i.e. Overt vs. Subclinical vs. Secondary vs. Autoimmune), any sign of an “off” thyroid marker must mean you need a replacement.

In theory, this sounds good—especially if you are feeling the effects of a thyroid condition. If you have a thyroid issue, you can’t wait to start taking your thyroid medication to make the dreadful symptoms go away – good bye constant fatigue, brain fog, stubborn weight gain, headaches, sleepless nights, depressed moods, and so on.

However, what happens if you take your medication and still don’t feel any better? Even when blood tests (TSH & TH) suggest that thyroid function is “back to normal,” many individuals still feel like they did prior to the medication.

Unfortunately, thyroid formulas are not always the panacea they are made out to be, often yielding mixed or subpar results for some—especially if you’re not on the right formula for you.

Here are 6 reasons your thyroid medications may not work:

1. You’re Not Absorbing the Thyroxine Hormone in the Medicine

Simply put, if you have a gut or liver issue, your body will not metabolize the thyroid medication properly.

2. You’re Overdiagnosed or Overtreating a Thyroid Problem

Your thyroid may not be the issue. Common culprits behind “thyroid symptoms” include:

Underlying gut pathologies (bacterial overgrowth, low stomach acid, parasitic infection, bacterial infection, H. pylori)

Chronic stress & HPA Axis Dysfunction (adrenal, cortisol and hormone imbalances)

Underfunctioning pituitary (controls the growth, development and function of other endocrine glands)

Environmental toxic burden

Low immune function

Reduced oxygen to cells (iron deficiency or in some cases, iron overload)

Blood sugar imbalances

Other chronic diseases, inflammation or underlying infections (Lyme disease, hepatitis C, IBD, etc.)

Long-term medication use or drug-induced hypothyroidism (overdose of thyroid hormones or other hormones)

Nutrient deficiencies (selenium, copper, iodine, zinc, pyridoxal 5 phosphate, zinc, magnesium)

3. You Have a T4—>T3 Conversion Problem (Not a Thyroid Problem)

Your cells must be able to convert T4 to T3, the active form of thyroid hormone, in order to produce energy. If they can’t make the conversion, you may still experience thyroid symptoms while on the medication. What causes poor conversion? Inflammation! Inflammation decreases the conversion of T4 to T3. T4 is the inactive form of thyroid hormone. Furthermore, the body has to convert it to the active T3 form before it can be used. Most synthetic hormone medications on the market are T4. If you give a T4 medication (like Synthroid, Levoxyl, Unithroid, etc.) to a person with inflammation already, it’s not going to work because they can’t convert the T4 to T3.

On bloodwork, a red flag that you’re having conversion issues is having low levels of T3 with normal T4 and either low or normal TSH—also known as “low T3 syndrome”. Although it does involve low levels of T3 (the most active form of thyroid hormone), it is not caused by a problem with the thyroid gland.

Low T3 Syndrome is a byproduct of the following “inflammatory” issues:

Chronic stress (HPA Axis Dysregulaton) and increase in inflammatory markers (particularly inflammatory cytokine TNF-alpha)

Under-active pituitary function (your pituitary cannot produce thyrotropin to then produce T4 and T3)

Gut or liver issues (20% of your active thyroid hormone (T3) is converted in your gut and the remaining 80% is converted by other organs, especially the liver, brain, skeletal muscle and kidneys)

Alterations in the carrier proteins that transport T4 and T3 hormones throughout your body (due to stress or nutrient deficiencies)

Changes in YOUR thyroid hormone receptors (THR)—inhibiting or over consuming thyroid hormones

4. You Have Autoimmune Thyroid

Hashimoto’s and Grave’s disease are inflammatory conditions wherein the thyroid attacks itself. The top twos driver of autoimmunity are intestinal permeability (“leaky gut”) and triggers (inflammation) that “turn on” the genes of autoimmunity—not poor thyroid function.

If you’re taking a thyroid medication for a condition—particularly if you have an undiagnosed autoimmune condition—but you’re not addressing your gut health, inflammation and personal triggers (from fluoride in your water and toothpaste, to birth control pill use, antibiotic history, mold in your home, etc.) then medicine won’t do a body good.

5. You’re Medications are Contraindicated

Interestingly, many medications—or supplements for that matter—produce drug interactions with thyroid  medication. For instance, estrogen found in birth control pills can exacerbate thyroid dysfunction. Even slight alterations in the dosing or absorption of medications can impact the effect of thyroid hormones. Additionally, do your research on what you are currently taking to uncover for yourself how medications may affect the assimilation or absorption of thyroid hormones.

Beyond interactions as well, medications for other health conditions may have a direct effect on the health of your thyroid in other ways—destroying thyroid cells and tissue, impacting natural thyroid hormone production and triggering the immune processes of the thyroid gland.

According to pharmacist Isabella Wentz, the top 9 drugs and chemicals that may affect thyroid function include:

Lithium (SSRI for bipolar, depression)

Amiodarone (heart disease)

Fluoride (toothpaste, water)

Hormone Replacement or Birth Control

Proton Pump Inhibitors (PPI’s for acide reflux)

Interferon (cancer drug)

Accutane (skin conditions)

Iodine (contraindicated if you have a selenium deficiency or you do not have a true iodine deficiency)

Botox (plastic surgery)

Also, if medical reasons warrant your thyroid medication use, it is even more important to optimize essential nutrients including probiotics and prebiotics, magnesium, zinc, B-vitamins and glutathione.

6. You’re Taking the Wrong Dose or Type of Medicine for You

The strength and power of your thyroid changes over time—it fluctuates with the change of seasons, it gets weaker as you age, and it increases or decreases hormone production as you gain or lose weight or if you are under more stress than usual. However, when we take medication, it works in contrast. We do not modify thyroid medication immediately as we change our weight, as the seasons change or anything else happens to our body. As a result, you can have a mismatch between the medication dose you were prescribed and what your body currently needs.

In addition, unlike supplemental herbs and natural compounds, many medications are “synthetic” (fake)—leaving you feeling less than natural.

A blinded study comparing the effects of natural desiccated thyroid hormone (T4/T3) vs. levothyroxine (synthetic T4) found that the patients who took the more natural version felt better—despite normal blood work results on both trials. In the study, a total of 70 patients with hypothyroidism were treated with either desiccated thyroid extract or levothyroxine for 12 weeks followed by a switch to other option for another 16 weeks. The participants were “blinded” during both phases—they did not know the type of pill they received. After each treatment period patients were weighed, had blood tests, underwent psychometric testing and were asked which therapy they preferred.

The researchers reported that 49% of the patients preferred desiccated thyroid extract, 19% preferred levothyroxine and 23% had no preference. Desiccated thyroid extract use was also associated with more weight loss. There was no difference in the psychometric testing or in any symptoms. Lastly, both types of thyroid hormone were able to normalize the abnormal thyroid blood tests. Although desiccated thyroid extract is not widely used, this study showed that many patients preferred the more natural option as compared with levothyroxine, potentially worth considering with your healthcare provider if your symptoms are not improving on thyroid medication (1).

References:

Hoang TD et al Desiccated thyroid extract compared with levothyroxine in the treatment of hypothyroidism: A randomized, double-blind, crossover study. J Clin Endo- crinol Metab 2013;98:1982-90. Epub March 28, 2013.

 The post Thyroid Medication Does Not Always Work: 6 Reasons You Need to Know appeared first on Meet Dr. Lauryn.

Source/Repost=> https://drlauryn.com/wellness-knowledge/thyroid-medication-does-not-always-work/ ** Dr. Lauryn Lax __Nutrition. Therapy. Functional Medicine ** https://drlauryn.com/ Thyroid Medication Does Not Always Work: 6 Reasons You Need to Know via https://drlaurynlax.blogspot.com/

[clarencebfaber]

Thyroid Medication Does Not Always Work: 6 Reasons You Need to Know

When it comes to thyroid medication, there is no one-size-fits-all answer.

Medication is often viewed as the “panacea” in conventional healthcare.

Headache? Pop an Advil.

High blood pressure? Take a statin.

Unwanted weight gain, fatigue or swelling?

Thyroid medication to the rescue.

Thyroid medication, specifically levothyroxine (Levothyroid® Synthroid®, Levoxyl®, and Armour®),  are the most prescribed drugs in the nation—ranking above statins, SSRI’s and the birth control pill. Since many conventional practitioners do not typically consider the different variations of thyroid disease (i.e. Overt vs. Subclinical vs. Secondary vs. Autoimmune), any sign of an “off” thyroid marker must mean you need a replacement.

In theory, this sounds good—especially if you are feeling the effects of a thyroid condition. If you have a thyroid issue, you can’t wait to start taking your thyroid medication to make the dreadful symptoms go away – good bye constant fatigue, brain fog, stubborn weight gain, headaches, sleepless nights, depressed moods, and so on.

However, what happens if you take your medication and still don’t feel any better? Even when blood tests (TSH & TH) suggest that thyroid function is “back to normal,” many individuals still feel like they did prior to the medication.

Unfortunately, thyroid formulas are not always the panacea they are made out to be, often yielding mixed or subpar results for some—especially if you’re not on the right formula for you.

Here are 6 reasons your thyroid medications may not work:

1. You’re Not Absorbing the Thyroxine Hormone in the Medicine

Simply put, if you have a gut or liver issue, your body will not metabolize the thyroid medication properly.

2. You’re Overdiagnosed or Overtreating a Thyroid Problem

Your thyroid may not be the issue. Common culprits behind “thyroid symptoms” include:

Underlying gut pathologies (bacterial overgrowth, low stomach acid, parasitic infection, bacterial infection, H. pylori)

Chronic stress & HPA Axis Dysfunction (adrenal, cortisol and hormone imbalances)

Underfunctioning pituitary (controls the growth, development and function of other endocrine glands)

Environmental toxic burden

Low immune function

Reduced oxygen to cells (iron deficiency or in some cases, iron overload)

Blood sugar imbalances

Other chronic diseases, inflammation or underlying infections (Lyme disease, hepatitis C, IBD, etc.)

Long-term medication use or drug-induced hypothyroidism (overdose of thyroid hormones or other hormones)

Nutrient deficiencies (selenium, copper, iodine, zinc, pyridoxal 5 phosphate, zinc, magnesium)

3. You Have a T4—>T3 Conversion Problem (Not a Thyroid Problem)

Your cells must be able to convert T4 to T3, the active form of thyroid hormone, in order to produce energy. If they can’t make the conversion, you may still experience thyroid symptoms while on the medication. What causes poor conversion? Inflammation! Inflammation decreases the conversion of T4 to T3. T4 is the inactive form of thyroid hormone. Furthermore, the body has to convert it to the active T3 form before it can be used. Most synthetic hormone medications on the market are T4. If you give a T4 medication (like Synthroid, Levoxyl, Unithroid, etc.) to a person with inflammation already, it’s not going to work because they can’t convert the T4 to T3.

On bloodwork, a red flag that you’re having conversion issues is having low levels of T3 with normal T4 and either low or normal TSH—also known as “low T3 syndrome”. Although it does involve low levels of T3 (the most active form of thyroid hormone), it is not caused by a problem with the thyroid gland.

Low T3 Syndrome is a byproduct of the following “inflammatory” issues:

Chronic stress (HPA Axis Dysregulaton) and increase in inflammatory markers (particularly inflammatory cytokine TNF-alpha)

Under-active pituitary function (your pituitary cannot produce thyrotropin to then produce T4 and T3)

Gut or liver issues (20% of your active thyroid hormone (T3) is converted in your gut and the remaining 80% is converted by other organs, especially the liver, brain, skeletal muscle and kidneys)

Alterations in the carrier proteins that transport T4 and T3 hormones throughout your body (due to stress or nutrient deficiencies)

Changes in YOUR thyroid hormone receptors (THR)—inhibiting or over consuming thyroid hormones

4. You Have Autoimmune Thyroid

Hashimoto’s and Grave’s disease are inflammatory conditions wherein the thyroid attacks itself. The top twos driver of autoimmunity are intestinal permeability (“leaky gut”) and triggers (inflammation) that “turn on” the genes of autoimmunity—not poor thyroid function.

If you’re taking a thyroid medication for a condition—particularly if you have an undiagnosed autoimmune condition—but you’re not addressing your gut health, inflammation and personal triggers (from fluoride in your water and toothpaste, to birth control pill use, antibiotic history, mold in your home, etc.) then medicine won’t do a body good.

5. You’re Medications are Contraindicated

Interestingly, many medications—or supplements for that matter—produce drug interactions with thyroid  medication. For instance, estrogen found in birth control pills can exacerbate thyroid dysfunction. Even slight alterations in the dosing or absorption of medications can impact the effect of thyroid hormones. Additionally, do your research on what you are currently taking to uncover for yourself how medications may affect the assimilation or absorption of thyroid hormones.

Beyond interactions as well, medications for other health conditions may have a direct effect on the health of your thyroid in other ways—destroying thyroid cells and tissue, impacting natural thyroid hormone production and triggering the immune processes of the thyroid gland.

According to pharmacist Isabella Wentz, the top 9 drugs and chemicals that may affect thyroid function include:

Lithium (SSRI for bipolar, depression)

Amiodarone (heart disease)

Fluoride (toothpaste, water)

Hormone Replacement or Birth Control

Proton Pump Inhibitors (PPI’s for acide reflux)

Interferon (cancer drug)

Accutane (skin conditions)

Iodine (contraindicated if you have a selenium deficiency or you do not have a true iodine deficiency)

Botox (plastic surgery)

Also, if medical reasons warrant your thyroid medication use, it is even more important to optimize essential nutrients including probiotics and prebiotics, magnesium, zinc, B-vitamins and glutathione.

6. You’re Taking the Wrong Dose or Type of Medicine for You

The strength and power of your thyroid changes over time—it fluctuates with the change of seasons, it gets weaker as you age, and it increases or decreases hormone production as you gain or lose weight or if you are under more stress than usual. However, when we take medication, it works in contrast. We do not modify thyroid medication immediately as we change our weight, as the seasons change or anything else happens to our body. As a result, you can have a mismatch between the medication dose you were prescribed and what your body currently needs.

In addition, unlike supplemental herbs and natural compounds, many medications are “synthetic” (fake)—leaving you feeling less than natural.

A blinded study comparing the effects of natural desiccated thyroid hormone (T4/T3) vs. levothyroxine (synthetic T4) found that the patients who took the more natural version felt better—despite normal blood work results on both trials. In the study, a total of 70 patients with hypothyroidism were treated with either desiccated thyroid extract or levothyroxine for 12 weeks followed by a switch to other option for another 16 weeks. The participants were “blinded” during both phases—they did not know the type of pill they received. After each treatment period patients were weighed, had blood tests, underwent psychometric testing and were asked which therapy they preferred.

The researchers reported that 49% of the patients preferred desiccated thyroid extract, 19% preferred levothyroxine and 23% had no preference. Desiccated thyroid extract use was also associated with more weight loss. There was no difference in the psychometric testing or in any symptoms. Lastly, both types of thyroid hormone were able to normalize the abnormal thyroid blood tests. Although desiccated thyroid extract is not widely used, this study showed that many patients preferred the more natural option as compared with levothyroxine, potentially worth considering with your healthcare provider if your symptoms are not improving on thyroid medication (1).

References:

Hoang TD et al Desiccated thyroid extract compared with levothyroxine in the treatment of hypothyroidism: A randomized, double-blind, crossover study. J Clin Endo- crinol Metab 2013;98:1982-90. Epub March 28, 2013.

 The post Thyroid Medication Does Not Always Work: 6 Reasons You Need to Know appeared first on Meet Dr. Lauryn.

Source/Repost=> https://drlauryn.com/wellness-knowledge/thyroid-medication-does-not-always-work/ ** Dr. Lauryn Lax __Nutrition. Therapy. Functional Medicine ** https://drlauryn.com/

Thyroid Medication Does Not Always Work: 6 Reasons You Need to Know via https://drlaurynlax.weebly.com/

[brian-cdates]

Thyroid Medication Does Not Always Work: 6 Reasons You Need to Know

When it comes to thyroid medication, there is no one-size-fits-all answer.

Medication is often viewed as the “panacea” in conventional healthcare.

Headache? Pop an Advil.

High blood pressure? Take a statin.

Unwanted weight gain, fatigue or swelling?

Thyroid medication to the rescue.

Thyroid medication, specifically levothyroxine (Levothyroid® Synthroid®, Levoxyl®, and Armour®),  are the most prescribed drugs in the nation—ranking above statins, SSRI’s and the birth control pill. Since many conventional practitioners do not typically consider the different variations of thyroid disease (i.e. Overt vs. Subclinical vs. Secondary vs. Autoimmune), any sign of an “off” thyroid marker must mean you need a replacement.

In theory, this sounds good—especially if you are feeling the effects of a thyroid condition. If you have a thyroid issue, you can’t wait to start taking your thyroid medication to make the dreadful symptoms go away – good bye constant fatigue, brain fog, stubborn weight gain, headaches, sleepless nights, depressed moods, and so on.

However, what happens if you take your medication and still don’t feel any better? Even when blood tests (TSH & TH) suggest that thyroid function is “back to normal,” many individuals still feel like they did prior to the medication.

Unfortunately, thyroid formulas are not always the panacea they are made out to be, often yielding mixed or subpar results for some—especially if you’re not on the right formula for you.

Here are 6 reasons your thyroid medications may not work:

1. You’re Not Absorbing the Thyroxine Hormone in the Medicine

Simply put, if you have a gut or liver issue, your body will not metabolize the thyroid medication properly.

2. You’re Overdiagnosed or Overtreating a Thyroid Problem

Your thyroid may not be the issue. Common culprits behind “thyroid symptoms” include:

Underlying gut pathologies (bacterial overgrowth, low stomach acid, parasitic infection, bacterial infection, H. pylori)

Chronic stress & HPA Axis Dysfunction (adrenal, cortisol and hormone imbalances)

Underfunctioning pituitary (controls the growth, development and function of other endocrine glands)

Environmental toxic burden

Low immune function

Reduced oxygen to cells (iron deficiency or in some cases, iron overload)

Blood sugar imbalances

Other chronic diseases, inflammation or underlying infections (Lyme disease, hepatitis C, IBD, etc.)

Long-term medication use or drug-induced hypothyroidism (overdose of thyroid hormones or other hormones)

Nutrient deficiencies (selenium, copper, iodine, zinc, pyridoxal 5 phosphate, zinc, magnesium)

3. You Have a T4—>T3 Conversion Problem (Not a Thyroid Problem)

Your cells must be able to convert T4 to T3, the active form of thyroid hormone, in order to produce energy. If they can’t make the conversion, you may still experience thyroid symptoms while on the medication. What causes poor conversion? Inflammation! Inflammation decreases the conversion of T4 to T3. T4 is the inactive form of thyroid hormone. Furthermore, the body has to convert it to the active T3 form before it can be used. Most synthetic hormone medications on the market are T4. If you give a T4 medication (like Synthroid, Levoxyl, Unithroid, etc.) to a person with inflammation already, it’s not going to work because they can’t convert the T4 to T3.

On bloodwork, a red flag that you’re having conversion issues is having low levels of T3 with normal T4 and either low or normal TSH—also known as “low T3 syndrome”. Although it does involve low levels of T3 (the most active form of thyroid hormone), it is not caused by a problem with the thyroid gland.

Low T3 Syndrome is a byproduct of the following “inflammatory” issues:

Chronic stress (HPA Axis Dysregulaton) and increase in inflammatory markers (particularly inflammatory cytokine TNF-alpha)

Under-active pituitary function (your pituitary cannot produce thyrotropin to then produce T4 and T3)

Gut or liver issues (20% of your active thyroid hormone (T3) is converted in your gut and the remaining 80% is converted by other organs, especially the liver, brain, skeletal muscle and kidneys)

Alterations in the carrier proteins that transport T4 and T3 hormones throughout your body (due to stress or nutrient deficiencies)

Changes in YOUR thyroid hormone receptors (THR)—inhibiting or over consuming thyroid hormones

4. You Have Autoimmune Thyroid

Hashimoto’s and Grave’s disease are inflammatory conditions wherein the thyroid attacks itself. The top twos driver of autoimmunity are intestinal permeability (“leaky gut”) and triggers (inflammation) that “turn on” the genes of autoimmunity—not poor thyroid function.

If you’re taking a thyroid medication for a condition—particularly if you have an undiagnosed autoimmune condition—but you’re not addressing your gut health, inflammation and personal triggers (from fluoride in your water and toothpaste, to birth control pill use, antibiotic history, mold in your home, etc.) then medicine won’t do a body good.

5. You’re Medications are Contraindicated

Interestingly, many medications—or supplements for that matter—produce drug interactions with thyroid  medication. For instance, estrogen found in birth control pills can exacerbate thyroid dysfunction. Even slight alterations in the dosing or absorption of medications can impact the effect of thyroid hormones. Additionally, do your research on what you are currently taking to uncover for yourself how medications may affect the assimilation or absorption of thyroid hormones.

Beyond interactions as well, medications for other health conditions may have a direct effect on the health of your thyroid in other ways—destroying thyroid cells and tissue, impacting natural thyroid hormone production and triggering the immune processes of the thyroid gland.

According to pharmacist Isabella Wentz, the top 9 drugs and chemicals that may affect thyroid function include:

Lithium (SSRI for bipolar, depression)

Amiodarone (heart disease)

Fluoride (toothpaste, water)

Hormone Replacement or Birth Control

Proton Pump Inhibitors (PPI’s for acide reflux)

Interferon (cancer drug)

Accutane (skin conditions)

Iodine (contraindicated if you have a selenium deficiency or you do not have a true iodine deficiency)

Botox (plastic surgery)

Also, if medical reasons warrant your thyroid medication use, it is even more important to optimize essential nutrients including probiotics and prebiotics, magnesium, zinc, B-vitamins and glutathione.

6. You’re Taking the Wrong Dose or Type of Medicine for You

The strength and power of your thyroid changes over time—it fluctuates with the change of seasons, it gets weaker as you age, and it increases or decreases hormone production as you gain or lose weight or if you are under more stress than usual. However, when we take medication, it works in contrast. We do not modify thyroid medication immediately as we change our weight, as the seasons change or anything else happens to our body. As a result, you can have a mismatch between the medication dose you were prescribed and what your body currently needs.

In addition, unlike supplemental herbs and natural compounds, many medications are “synthetic” (fake)—leaving you feeling less than natural.

A blinded study comparing the effects of natural desiccated thyroid hormone (T4/T3) vs. levothyroxine (synthetic T4) found that the patients who took the more natural version felt better—despite normal blood work results on both trials. In the study, a total of 70 patients with hypothyroidism were treated with either desiccated thyroid extract or levothyroxine for 12 weeks followed by a switch to other option for another 16 weeks. The participants were “blinded” during both phases—they did not know the type of pill they received. After each treatment period patients were weighed, had blood tests, underwent psychometric testing and were asked which therapy they preferred.

The researchers reported that 49% of the patients preferred desiccated thyroid extract, 19% preferred levothyroxine and 23% had no preference. Desiccated thyroid extract use was also associated with more weight loss. There was no difference in the psychometric testing or in any symptoms. Lastly, both types of thyroid hormone were able to normalize the abnormal thyroid blood tests. Although desiccated thyroid extract is not widely used, this study showed that many patients preferred the more natural option as compared with levothyroxine, potentially worth considering with your healthcare provider if your symptoms are not improving on thyroid medication (1).

References:

Hoang TD et al Desiccated thyroid extract compared with levothyroxine in the treatment of hypothyroidism: A randomized, double-blind, crossover study. J Clin Endo- crinol Metab 2013;98:1982-90. Epub March 28, 2013.

The post Thyroid Medication Does Not Always Work: 6 Reasons You Need to Know appeared first on Meet Dr. Lauryn.

Source/Repost=> https://drlauryn.com/wellness-knowledge/thyroid-medication-does-not-always-work/ ** Dr. Lauryn Lax __Nutrition. Therapy. Functional Medicine ** https://drlauryn.com/ Thyroid Medication Does Not Always Work: 6 Reasons You Need to Know via http://drlaurynlax.tumblr.com/

[adreamtotraveltheworld]

Cannabidiol and its therapeutic uses

Cannabidiol More than 100 cannabinoids have been identified within the cannabis plant, that is, chemical compounds found naturally in the plant. One of the most abundant is cannabidiol (CBD), which can represent up to 45% of the plant extract. Many of the Cannabis Sativa strains give rise to CBD or cannabidiol but do so in small amounts. In fact, only certain branches of the plant contain sufficient concentration of CBD to extract it in a useful way.

The first time that CBD was isolated from the cannabis plant was between 1930 and 1940 by researchers at the University of Illinois (USA). However, it was not until the 1960s when Professor Rafael Mechoulam managed to describe its structure and chemical composition. Since 2013, PubMed, an American medical research database, has indexed more than 1,500 studies on cannabidiol. Because of this, many scientists consider CBD to be one of the most important cannabinoids discovered to date.

MEDICINAL EFFECTS OF CANNABIDIOL Compared with other cannabinoids, Cannabidiol has gained a lot of importance in the therapeutic field because it lacks the psychoactive properties typical of THC, which are reduced when using CBD and THC together.

This means similar amounts of CBD and THC (ratio of 1:1 or even higher THC) can be administered without strong adverse side effects due to high amounts of THC (such as the psychoactive effect, tachycardia, anxiety attacks, among others) (Zuardi and al., 1982) [1].

Although much remains to be investigated on the properties of cannabidiol, there are several existing studies that have demonstrated their benefits from a clinical point of view credit card processing for cbd .

Its most important therapeutic effects are given by its properties [2]:

Anxiolytic Analgesic Antiemetic Antiepileptic Antitumor Antioxidant Anti Inflammatory Antipsychotic Immunomodulators Antibacterial and antifungal Neuroprotective Antirheumatic Sleep Inducer Although all the benefits of cannabidiol are not fully known, there are studies that have proven its benefits from a clinical point of view. For example, researchers have shown its relationship with the immune system. Thus, it has been verified that, in some cellular lines of the immune system, CBD has the capacity to inhibit the production of some cytokines (IL-8, IL-10, TNF-D, IFNJ). These studies directly relate CBD to beneficial effects on inflammatory/autoimmune diseases. Thus, CBD has anti-inflammatory, analgesic, anxiolytic and antipsychotic properties. There are also studies that have related cannabidiol to chronic pain relief or to treat epilepsy, amongst other illnesses.

Other research has focused on the effects of cannabidiol on arthritis. One trial with mice showed that a treatment with CBD (both oral and intraperitoneal) managed to block the disease, thus paralyzing its progression. These effects are linked to the immunosuppressive activity and the anti-inflammatory properties of this cannabinoid (Malfait et al., 2000).

In a disease such as cancer, cannabis oil in cancer causes a sedative effect in most cases and inhibits the transmission of nerve signals associated with pain. It has also been witnessed that CBD reduces the growth of human breast cancer cells in vitro and in vivo in mice, and reduces their invasiveness.

[ecoorganic]

Mailbag: Future Changes to NFL's TV Packages, Impact of Canceled College Games

Plus, the impact a canceled college season has on the NFL, what to expect from Gardner Minshew in Year 2, whether this season will be seen as legitimate and more.

It’s a sad day in the football world. Blue-blood programs that are 41 (Michigan), 33 (Penn State), 32 (USC) and 30 (Ohio State and Nebraska) years older than the NFL itself won’t be playing this fall. And no matter who you blame, it’s a shame that

we’re here.

The slow death march college football seems to be on will absolute reverberate in the NFL world. We’re going to get to that, and a whole lot more, in this week’s mailbag. …

From Brock Ascher (@BrockAscher): What happens to NFL TV rights in the near future? Will I ever be able to get rid of DirecTV? Will I ever be able to buy a one-team out of market package?

Brock, my guess is the over-the-air packages will probably remain the same. I think Thursday night is the one variable in all this, with the potential Disney snaps it up so it can put either MNF or TNF on ABC, with the other staying on ESPN, ideal for them for cable-fee reasons. (My guess is Fox is finished with TNF.) The biggest difference you’d notice could come in structure. I was told by two execs that the NFL has discussed jettisoning the divvying up of Sunday afternoons by conference (the cross-flex would be a precursor to that).

It’d give the NFL more flexibility and, in this scenario, you could have Fox and CBS simply split up the games, via some sort of “draft.”

After that, we can dive into how streaming (where the younger audience lives) plays into all of this, and how the Sunday Ticket package you’re referencing factors into that. AT&T now owns DirecTV, which has the Ticket through 2022. The Ticket is vital to DirecTV's survival. How much does AT&T care about that? We’ll see, because the NFL has discussed the idea of moving the Ticket to a streaming service, where a younger audience lives.

You can imagine what the Ticket would be worth to ESPN-Plus, Peacock, HBO Max, DAZN or Amazon Prime. How many people would jump on those services if the Ticket was there? Based on DirecTV’s numbers, the answer is a lot. And part of the NFL’s concern about production quality in doing something like this may have been alleviated with how smoothly Amazon Prime’s venture into creating such a product for the Premier League over in the UK went.

As for the a la carte end of this, we’ll see. I think that’s coming, but it might be further down the line, and whoever were to win the Ticket rights would be involved in all of that. The bottom line here: Media’s changing fast, and the NFL is preparing for that.

From Jonathan Barakat (@jonathanbarakat): How do you think Gardner Minshew will play this year? Will he exceed expectations? Also what do you think of D.J. Chark coming into his third year?

Jonathan, I’ll give you what I like and what I don’t like about Gardner Minshew’s situation.

What I like: Minshew gets to play for Jay Gruden, who’s immediately made a big difference for young quarterbacks in both his previous NFL homes (Kirk Cousins in D.C. and Andy Dalton in Cincinnati), and in one of those cases actually did it with a rookie coming off the lockout, which is somewhat analogous to this situation. Also, D.J. Chark gives Minshew a strong No. 1 target, and Doug Marrone will use the run game to support him.

What I don’t like: It’s pretty clear where Jacksonville stands on Cam Robinson, and having an issue at left tackle isn’t great—particularly in a year when it’s going to be tough to work out offensive line issues on the fly. Also, the viability of the run game rides largely on Leonard Fournette, who hasn’t been the most reliable guy over his first three NFL seasons. And beyond Chark, there are question marks at receiver and tight end.

So all in all, it’s not a complete mess, but not really setup for Minshew to have a breakthrough sophomore campaign.

From Roberta Wears A Mask You Should Too (@AceandJasper): How will the teams take care of season ticket holders who won't get to sit in their front row seats even for a game or two?

Most teams are rolling payments over or refunding—and I can’t imagine any haven’t already given their season-ticket holders the choice to opt out and hold on to the rights to their seats in 2021. I think, at this point, we know that the season isn’t going to start with full stadiums anywhere. How will it end? That’s four months from now. And I think the last four months should be enough to keep anyone from making predictions that far ahead.

From Erik Ghirarduzzi (@eghirarduzzi): Given the circumstance around this season, currently known and ones yet to come, how legit would a SB winner be? There are teams at a competitive disadvantage, through no fault of their own, already and the season hasn't started.

Erik, this is a great question—I do believe this year will be remembered, if it’s completed, like the strike years of 1982 and ’87. In ’82, teams played nine games, the divisions were temporarily abolished, and a 16-team playoff was staged. In ’87, just six quarterbacks broke 3,000 yards passing, and just two backs reached 1,000 yards rushing. In both years, interestingly enough, Joe Gibbs led Washington to a championship.

Now, I don’t think the season necessarily will be cut to nine games (as ’82 was), nor will you have the oddity of replacement players en masse (like ’87 had). But I do think there’ll be aspects of the season that will go sideways, and the NFL, to its credit, knows it and is preparing for that.

So how are ’82 and ’87 remembered? I think most people who didn’t live it (I was way too young, 2, to remember the former, and have faint memories of the latter) probably wouldn’t look at championships or accolades from that year (John Elway was MVP and Reggie White DPOY in ’87) much differently. But it doesn’t take much Google acumen to discover how weird all the numbers from those seasons look.

To me, that feels like the likely result of this year.

From Dan Heiserman (@HeisermanDan): Has any player in history ever been on more teams than Josh McCown?

Speaking of Google, Dan, I didn’t know the answer to this and was legitimately interested, so I looked and found that legend-of-the-aughts J.T. O’Sullivan was on 11 (!) different NFL teams (Saints, Packers, Bears, Vikings, Patriots, Panthers, Lions, Niners, Bengals, Chargers, Raiders), which unbelievably matches McCown’s number (Cardinals, Lions, Raiders, Dolphins, Panthers, Niners, Bears, Bucs, Browns, Jets, Eagles).

A little more bumping around the internet showed that kicker Bill Cundiff was, at one point or another, with 13 different NFL teams (Cowboys, Bucs, Packers, Saints, Falcons, Chiefs, Lions, Browns, Ravens, Washington, Niners, Jets, Bills). And I’m sure there are other backup quarterbacks and kickers—playing positions where careers are longer, which facilitates this sort of movement—out there like these guys.

All of them must have pretty cool jersey displays in their basements.

From SUPER BOWL SUPER BROWNS HELL YEAH!!! (@WAH3rd): Should I still go back to the party barn and start drinking at 7 a.m. and yell at people on Saturdays this fall like I used to?

This is a very specific message just for me and a lot of other people who were in legit mourning on Tuesday night—and this will be absolutely be one of the Lane Avenue casualties (right there with the Varsity Club) of the depressing news we all got. It’s hard to describe the Party Barn if you don’t know what it is already, so I won’t try.

And the answer is yes.

From Skeeter6265 (@skeeter6265): Do you think Ohio will beat Michigan?

I was very excited for Michigan to celebrate the 20th anniversary of its last win in Columbus—that was in the fall of my junior year—this November. Maybe that team can have a Zoom reunion to commemorate it now.

From FootballFan64 (@FFan64): With college coaches out of the running for NFL openings since their season is moving to the spring, which NFL coordinators do you expect to be coveted for any newly vacated HC positions? Who is this year’s Matt Rhule?

Well, Football Fan, I’m not sure that colleges playing in the spring (if that even happens) would prevent NFL teams from making runs at coaches at that level. If, and again it’s a big if, college football goes in the spring semester, my guess would be the season would start in February (you can’t just start the season the minute kids get back to campus). The NFL coaching carousel is spinning at the beginning of January. So there’d be time.

The NFL coordinator names you’ll hear most are some of the usual suspects from the last couple cycles—Patriots OC Josh McDaniels, Chiefs OC Eric Bieniemy, Ravens coordinators Greg Roman and Wink Martindale, 49ers DC Robert Saleh and Saints DC Dennis Allen would be on that list. I’d also just keep an eye on Falcons DC Raheem Morris, Chiefs pass-game coordinator Mike Kafka and Titans OC Arthur Smith as names that could pop up.

As for the next Matt Rhule, the NFL will continue to have interest in Oklahoma’s Lincoln Riley, and Ohio State’s Ryan Day is beginning to be held in that sort of regard among those in the pros. But both those guys have jobs that are very well-paying and, in reality, better than the majority of jobs they’d find in the NFL. Stanford’s David Shaw and Northwestern’s Pat Fitzgerald have long been on the radar of the league, but haven’t shown much appetite for leaving their alma maters. And Minnesota’s P.J. Fleck is a fun name to keep an eye on.

From Shawn Tangen (@SMTangen): How is Kevin Warren viewed within NFL circles?

Shawn, I’d say it’s pretty mixed. And I got some pretty strong reaction from certain corners of the NFL about the Big Ten commissioner (and former Vikings executive) after the conference canceled its season on Tuesday.

Warren was a polarizing figure inside the Minnesota locker room during the Adrian Peterson scandal of 2014—Peterson felt like Warren betrayed him to the point where Warren’s promotion to COO was a sticking point in the star’s contract negotiation. That was a situation that coach Mike Zimmer had to manage, and ultimately defuse, on the ground with the players, and it’s just one example in his NFL past where he’s rankled co-workers.

On top of that, many NFL people felt like Warren’s move to the Big 10 was with designs on eventually making a run at becoming NFL commissioner down the line. In that regard, the final result of his management of the last week (a result we won’t have for a while) will probably go a long way in determining whether those aspirations are realistic or not. I’d just hope his decisions here weren’t made with that in mind.

From Brycen Papp (@BrycenPapp): Do you think this season will be a massive shift in the way the draft process works? Will the NFL lower the requirements for college players to be draft eligible to two years instead of three?

Brycen, I think there will be a shift to the draft process to a degree, and we’re going to get into that in the GamePlan on Thursday. But I do want to get into your question on the NFL’s age requirement, because it’s a fascinating one—and something we covered extensively on the podcast this week.

I believe many of the best players in the Big 10 and Pac-12, from places like Ohio State, Oregon, USC, Penn State and Michigan, will sign with agents now, and go into draft prep. Because of that, and how the Big 10/Pac-12 shutdown devalues this college season, I think we’ll also see some attrition from the other conferences. That could lead to some players who only played two years of college football and skipped the required third year out of high school, going high in next April’s draft.

That, in turn, could open the door in the future for players with two good years on their resume skipping their junior year to protect themselves and prepare for the draft—in the same way Christian McCaffrey skipping his bowl game in 2016 gave others cover to do the same. At that point, the idea that players need three years of development to be NFL-ready gets broken down, and now you have guys taking a “gap year” instead.

Which isn’t good for the players, for college football or for the NFL.

It’s important to remember here too that it’s not college football keeping guys in school for three years. It’s pro football. The three-year rule is an NFL rule. And when Maurice Clarett and Mike Williams sued to become eligible for the draft in 2004, it wasn’t a school, a conference or the NCAA they sued. It was the NFL. So the ball would be in the NFL’s court on this one, if the situation comes to a head.

From Sam Perrone (@samjp33): Do you think the NFL would be willing to move the draft if the college football season bleeds into the spring?

I think, Sam, the NFL will do whatever it needs to in order to support the golden goose that is college football. Why? College football is very good for the NFL. And primarily for three reasons.

1) It’s a free minor league. The NFL, unlike the other sports, doesn’t have to fund a complex minor-league system to develop college-aged players. The expense of doing so in a sport like football would be astronomical and the opportunity to monetize it, as we’ve seen with other start-up leagues in the past, would be pretty limited.

2) It’s a marketing monster for star players coming in. Say what you will about Tim Tebow and Johnny Manziel—they were legit sports-world celebrities before they lifted a single dumbbell in preparation for the draft. Everyone knows who Joe Burrow, Tua Tagovialoa and Chase Young are. Ezekiel Elliott and Saquon Barkley were household names as collegians. And all of that is great for the NFL on so many different levels.

3) College football is the foundation for the NFL’s tentpole offseason event. The draft is The Draft because of college football. We’ve been watching most of the top players for years. It marries two wildly popular entertainment entities. The draft itself wouldn’t be nearly the event it is without college football.

So, in order to protect the sanctity of a spring college football season (as much of a sham as it might be) would the NFL be willing to move the draft back a few weeks? Well, of course it would be.

• Question or comment? Email us.

from Blogger https://ift.tt/3fO2YCN