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Data variables-PCS-Covid-19 and pregnancy

The study incorporated Prospective Cohort study design. For the Prospective Cohort study, the explanatory variables, which are the exposures, would be severity levels of symptoms. These levels are separated into four subgroups of cases as asymptomatic, mild, moderate, severe(extreme). These levels can be defined based on measurements of clinical indications of Covid-19 such as leukocyte, neutrophil‐to‐lymphocyte ratio (NLR), neutrophil, lymphocyte, platelet, D‐dimer, C‐reactive protein. The response variables would be maternal and infant mortality rates, premature birth time, fetal birth weight, maternal morbidity, maternal hospitalizations during pregnancy. The maternal mortality cases in this study should only include indirect obstetric maternal mortality cases with underlying disease being exposure to Covid-19 for primary outcome. The secondary outcomes are measured based on ICD-10 codes for Pregnancy, childbirth and the puerperium provided by CDC. The explanatory variables would be distinct values rather than continuous values. All the response variables would be binary values except for premature birth time and fetal birth weight which would be continuous values.

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Data collection for PCS-Covid-19 and pregnancy

Purposive sampling method is used to select subjects of study through inpatient/outpatient registries and records from OB/GYN clinics with the purpose of studying maternal mortality in pregnant women who were exposed to Covid-19. So, pregnant women who had a positive Covid-19 PCR test before pregnancy were excluded from the study. After enrollment, subjects would be separated into cases or controls based on positive or negative Covid-19 PCR test respectively. The outcomes are measured based on ICD-10 codes definitions for health events in pregnant women during or after delivery stage. Primary outcomes would be maternal and infant mortality rates. Secondary outcomes would be premature birth time, fetal birth weight, maternal morbidity, maternal hospitalizations during pregnancy. The outcomes are measured at UCMCCH as mentioned in 'Sample' blog of this study.

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Sample for PCS-Covid-19 and pregnancy.

The sample of 50 pregnant women was drawn from the University of Cincinnati Medical Center Christ Hospital (affiliate). These subjects were pregnant on or after November 2020. All the women were between the ages of 17 and 35 years with no record of smoking and drinking during pregnancy. All the subjects when entering the study will be healthy pregnant women with no underlying health condition. The subjects would be analyzed as two groups, one group exposed to Covid-19 after enrollment and other being a group of women who were not exposed to Covid-19 after enrollment.