#bioinformatics research

[sr71blackbirdd]

Writing was my first love, my unconditional love perhaps, but STEM I had to try to love. STEM has equations and p-values and sitting at your computer all day trying to filter your 200 KB of data while you slowly lose your mind. Maybe I should have been a lit major or creative writing or something that I loved so naturally, but I love waking up every day and being able to call myself a scientist, not because it was easy money, but because it was hard to love.

[febos]

Happy to share, ARTEMIS is now published at NAR!

https://doi.org/10.1093/nar/gkae758

ARTEMIS is a new tool for RNA/DNA 3D structure superposition and structure-based sequence alignment. Our benchmarks show that it outperforms the existing tools for both sequentially-ordered and topology-independent alignment.

ARTEMIS allowed us to identify an intriguing structural similarity between Lysine and M-box riboswitches (see the figure) and to describe the minor-groove/minor-groove helical packing motif. ARTEMIS is the first tool able to report several alternative superpositions, which makes it suitable for structural motif identification tasks.

ARTEMIS is available at GitHub: https://github.com/david-bogdan-r/ARTEMIS

Thanks to Davyd Bohdan, Janusz Bujnicki, & International Institute of Molecular and Cell Biology in Warsaw!

[mastergarryblogs]

Investor Alert: Why the Gene Silencing Market Could Be the Next Big Thing

Introduction

The global gene silencing market is experiencing unprecedented growth, driven by advancements in genetic research, increasing prevalence of genetic disorders, and the rising adoption of gene-silencing technologies in therapeutics and drug discovery. Valued at approximately USD 3.7 billion in 2024, the gene silencing market is projected to expand at a CAGR of over 17.6% from 2025 to 2032, reaching a valuation exceeding USD 15.9 billion by the end of the forecast period. This rapid expansion is fueled by the increasing demand for RNA interference (RNAi), CRISPR-based therapies, and antisense oligonucleotides (ASOs) for targeted gene modulation.

Breakthroughs in gene-editing tools, AI-driven bioinformatics, and nanoparticle-based delivery systems are accelerating innovation and adoption. The use of gene silencing in treating cancer, neurological disorders, and rare genetic diseases, alongside the expansion of personalized medicine and cell and gene therapy applications, continues to strengthen market growth. Additionally, strategic partnerships between biotech firms, pharmaceutical companies, and research institutions are propelling advancements in gene-based therapies.

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Gene Silencing Market Dynamics

Key Drivers

Growing Adoption of Gene Silencing in Therapeutics

Increasing application of RNAi, CRISPR-Cas9, and ASOs in gene therapy.

Expansion of precision medicine initiatives leveraging gene silencing for personalized treatment.

Rising Prevalence of Genetic Disorders and Cancer

Escalating demand for innovative treatments for hereditary diseases, cancer, and neurodegenerative disorders.

Emerging gene silencing applications in rare genetic conditions and metabolic disorders.

Advancements in Gene-Editing Technologies

Enhancements in CRISPR-Cas systems for precise genetic modifications.

AI-driven bioinformatics for target identification and therapeutic development.

Strategic Collaborations and Investments in R&D

Increased funding for gene therapy research from public and private sectors.

Expansion of contract research organizations (CROs) and biotech partnerships.

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Gene Silencing Market Challenges

Regulatory and Ethical Constraints

Stringent guidelines governing gene-editing technologies.

Ethical concerns regarding genetic modifications and long-term effects.

Complexities in Gene Delivery Mechanisms

Challenges associated with targeted delivery and minimizing off-target effects.

Development of safe and efficient non-viral and nanoparticle-based delivery systems.

Gene Silencing Market Segmentation

By Technology

RNA Interference (RNAi) – Dominating with a 45.6% gene silencing market share in 2024, growing at a CAGR of 18.4%.

CRISPR-Cas9 – Fastest-growing segment at a CAGR of 21.2%.

Antisense Oligonucleotides (ASOs) – Significant adoption in genetic therapeutics.

DNA Methylation-Based Silencing – Emerging applications in epigenetic modifications.

By Delivery Method

Nanoparticle-Based Delivery – Leading with a 42.7% market share, growing at 19.6% CAGR.

Viral Vector-Based Delivery – Expanding at a CAGR of 18.9%.

Electroporation & Physical Delivery Methods – Increasing adoption in clinical applications.

Chemical Delivery Methods – Advancements in stability and efficacy.

By Disease Type

Cancer – Leading with a 38.9% market share, projected to grow at a CAGR of 19.7%.

Neurodegenerative Diseases – Fastest-growing at a CAGR of 20.3%.

Hereditary and Infectious Diseases – Expanding clinical applications.

Cardiovascular Diseases and Others – Rising demand for novel gene therapies.

By Application

Therapeutics – Dominating with a 60.4% market share, growing at 19.9% CAGR.

Research & Development – Expanding as biotech firms invest in preclinical research.

By End-User

Biotechnology & Pharmaceutical Companies – Holding a 48.7% market share, growing at 18.8% CAGR.

Academic & Research Institutes – Increasing focus on CRISPR-based studies.

Contract Research Organizations (CROs) – Expanding service offerings.

Hospitals & Diagnostic Centers – Rising adoption of gene silencing diagnostics.

By Region

North America – Leading with a 46.2% market share, fueled by R&D investments and regulatory approvals.

Asia Pacific – Fastest-growing at a CAGR of 20.8%, driven by biotech innovations in China, Japan, and India.

Europe, South America, and Middle East & Africa – Steady market expansion.

Competitive Landscape

Key industry players include:

Alnylam Pharmaceuticals – Expanding RNAi-based therapeutic portfolio.

Benitec Biopharma Inc. – Partnering for next-generation RNAi therapies.

Phio Pharmaceuticals – Advancing RNAi-based cancer immunotherapy.

Avidity Biosciences, Riboxx GmbH, Integrated DNA Technologies (IDT), Dyne Therapeutics, Bit Bio, Comanche Biopharma, Thermo Electron Corporation, Temasek Life Sciences Laboratory Ltd., WuXi AppTec – Innovating in RNA-based therapeutics and strategic collaborations.

Emerging Trends and Future Outlook

Key Gene Silencing Market Trends

Expansion of Personalized Gene Therapies – Advancements in tailored treatments based on genetic profiling.

AI-Driven Drug Discovery – Integration of machine learning for gene target identification.

Development of Non-Viral Delivery Methods – Enhancing safety and efficiency.

CRISPR-Based Diagnostics and Therapeutics – Rapidly evolving applications in precision medicine.

Blockchain for Genetic Data Security – Addressing concerns related to data privacy and patient confidentiality.

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Future Projections

With continued advancements in genetic research, evolving regulatory frameworks, and increasing global investments in genomic medicine, the gene silencing market is set for sustained expansion. Companies investing in breakthrough RNA-based therapeutics, innovative gene-editing tools, and AI-driven bioinformatics will lead the next phase of growth. As clinical trial success rates improve and new partnerships emerge, gene silencing technologies will play an integral role in reshaping the future of medicine.

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[wickedhawtwexler]

guys i legitimately think i have found my ideal job

[cs-med-world-insights]

Announcement:

Hello everybody! Thank you so much for reblogging and liking our posts! We appreciate you so much for supporting us! We will soon be having a website for our blog! We will use this platform on Tumblr to show you guys sneak peeks and more stuff that we can’t wait to share until next week!

Stay Tuned!

Thank you for supporting us and your patience!

Make sure to follow us!

From,

@cs-med-world-insights

[gauricmi]

Maximizing Efficiency: Best Practices for Using Sequencing Consumables

By implementing these best practices, researchers can streamline sequencing workflows, increase throughput, and achieve more consistent and reproducible results in genetic research. Sequencing Consumables play a crucial role in genetic research, facilitating the preparation, sequencing, and analysis of DNA samples. To achieve optimal results and maximize efficiency in sequencing workflows, it's essential to implement best practices for using these consumables effectively.

Proper planning and organization are essential for maximizing efficiency when using Sequencing Consumables. Before starting a sequencing experiment, take the time to carefully plan out the workflow, including sample preparation, library construction, sequencing runs, and data analysis. Ensure that all necessary consumables, reagents, and equipment are readily available and properly labeled to minimize disruptions and delays during the experiment.

Optimizing sample preparation workflows is critical for maximizing efficiency in sequencing experiments. When working with Sequencing Consumables for sample preparation, follow manufacturer protocols and recommendations closely to ensure consistent and reproducible results. Use high-quality consumables and reagents, and perform regular quality control checks to monitor the performance of the workflow and identify any potential issues early on.

Utilizing automation technologies can significantly increase efficiency when working with Sequencing Consumables. Automated sample preparation systems and liquid handling robots can streamline repetitive tasks, reduce human error, and increase throughput. By automating sample processing and library construction workflows, researchers can save time and resources while improving consistency and reproducibility in sequencing experiments.

Get More Insights On This Topic:  Sequencing Consumables

[bio-stem]

Anyway this is my science blog!!! I’m glad I’m gonna have a space to share my stem related stuff cos I don’t wanna post it all over my IG or Facebook

[kamalkafir-blog]

Software Engineer (Machine Learning)

Job title: Software Engineer (Machine Learning) Company: Francis Crick Institute Job description: principles Practical MLOps experience of training and tuning deep learning models and evaluating performance (e.g working… with PyTorch to build deep learning pipelines) Experience with large language models including; RAG, prompt engineering… Expected salary: Location: London Job date: Sun, 22 Jun…

[febos]

#HiringAlert

Looking to tackle computational challenges of RNA folding and binding?

Come build new RNA algorithms as a #postdoc in my lab!

More info: https://euraxess.ec.europa.eu/jobs/350755

#Academia #Position #Job #Research #RNA #Structure #3D #Bioinformatics #Poland #Warsaw #IMolPAS #NCN

[hotzimbabwejobs]

Harness the Power of Data in Agriculture: Data Science Lecturer/Professor Opportunities at NUST! - March 2025

The National University of Science and Technology (NUST) is seeking passionate and experienced academics to join their Faculty of Agricultural Science and Technology as Lecturers/Senior Lecturers/Associate Professors in Agricultural Information Technology, specifically focusing on Data Science! If you’re excited about applying data-driven solutions to agricultural challenges, this is a fantastic…

[dekhocampus11]

B.Sc Life Sciences

B.Sc. Life Sciences Overview:

A Bachelor of Science (B.Sc.) in Life Sciences is a multidisciplinary undergraduate program designed to provide students with a comprehensive understanding of living organisms, their structures, functions, and the environments in which they exist. This degree typically spans three years (in many countries) and covers subjects from biology, chemistry, and physics to specialized areas such as molecular biology, genetics, and biotechnology. The program is often chosen by students who are interested in biological research, healthcare, environmental science, or pursuing higher studies in medical and life sciences fields.

The B.Sc. Life Sciences program is perfect for those passionate about understanding the fundamental processes that govern life, from the molecular level to entire ecosystems. It lays the foundation for various career paths, including research, healthcare, environmental conservation, and the biotechnology industry.

Academic Structure:

The academic curriculum in B.Sc. Life Sciences is a combination of theoretical knowledge and practical application through laboratory work and research. Typically, students are introduced to core subjects during the first year, with more specialized topics explored in the second and third years. The program is divided into several core subjects and electives, which might include:

1. Core Subjects:

Biology: This subject is the backbone of the Life Sciences degree and encompasses cellular biology, microbiology, ecology, and evolution. Students learn about the structure and function of living organisms and their interaction with the environment.

Biochemistry: Focuses on the chemical processes within and relating to living organisms. This subject is important for understanding how cells work at the molecular level.

Genetics: The study of genes, heredity, and variation in organisms. Genetics is a key area for students interested in fields like biotechnology, medical research, and molecular biology.

Zoology: Covers the study of animals, including their structure, function, classification, and behavior.

Botany: Focuses on plant biology, including plant structure, growth, reproduction, and ecology.

Physics and Chemistry: Basic understanding of physics and chemistry is essential for students to understand biochemical processes, molecular biology, and biophysics.

Environmental Science: An important interdisciplinary subject that examines the relationship between organisms and their environment, including issues such as conservation and sustainability.

2. Specialized Subjects (depending on the university):

Molecular Biology and Biotechnology: The study of living organisms at the molecular level, with a focus on genetic manipulation, cloning, and recombinant DNA technology.

Immunology: The study of the immune system, including diseases caused by immune deficiencies and how the body defends itself against pathogens.

Microbiology: The study of microorganisms like bacteria, viruses, fungi, and protozoa, with applications in medicine, agriculture, and industry.

Neurobiology: Focuses on the biology of the brain and nervous system, including neurological diseases and the relationship between brain function and behavior.

Bioinformatics: The application of computer science and data analytics in the management and analysis of biological data, especially useful in genomics and drug discovery.

Practical Learning:

The B.Sc. Life Sciences program places a significant emphasis on practical learning. Students engage in laboratory sessions, where they perform experiments, conduct research, and analyze data. These practical components help develop essential skills like critical thinking, problem-solving, and attention to detail. Additionally, many programs also encourage students to participate in fieldwork and internships, where they gain hands-on experience in real-world settings such as research labs, hospitals, and conservation projects.

Campus Life and Facilities:

University campuses are vibrant spaces where students from different backgrounds and cultures come together to pursue academic and extracurricular interests. For Life Sciences students, the campus offers various resources and facilities to support their academic and social lives.

1. Laboratories and Research Facilities:

Life Sciences students have access to state-of-the-art laboratories equipped with modern tools and technologies for conducting experiments. These facilities are crucial for students to develop practical skills in biological research. Research labs also provide opportunities for students to work alongside professors and researchers on innovative projects.

2. Libraries:

University libraries are essential resources for students, offering a vast collection of textbooks, journals, and online databases that aid in academic research and assignments. The library provides a quiet environment for study and group work, and many universities also offer access to specialized journals in life sciences and medicine.

3. Campus Clubs and Societies:

Most universities have clubs or societies related to biology and life sciences, where students can connect with like-minded individuals, organize events, and share knowledge. These clubs may host guest lectures, workshops, and discussions on topics related to the life sciences field, such as genetics, biotechnology, and environmental conservation. Joining these societies is a great way to network and deepen one’s academic interests.

4. Sports and Recreation:

Campus life is not just about academics; it also includes socializing and participating in various recreational activities. Many universities have sports facilities, gyms, and host inter-college competitions. Students can join sports teams, participate in fitness programs, or simply enjoy outdoor activities with friends.

5. Cultural and Social Events:

Universities often organize cultural events, festivals, and exhibitions, where students can showcase their talents, be it in performing arts, music, or dance. These events are excellent opportunities for students to take a break from their studies, interact with others, and form lifelong memories.

Student Life:

Being a student in the B.Sc. Life Sciences program is a dynamic experience, as students not only focus on academics but also engage in a variety of social and extracurricular activities. Below are some aspects of student life in the B.Sc. Life Sciences program:

1. Social Interactions:

University life is a time for students to forge lasting friendships and develop strong social networks. Students from diverse backgrounds come together to share their interests and experiences. Group study sessions are common, especially in the Life Sciences program, as students often collaborate on research projects, laboratory work, and assignments.

2. Balancing Academics and Social Life:

Life Sciences students typically have a heavy academic load, especially during exams and lab sessions. However, universities encourage a balanced lifestyle, with many extracurricular activities and social events to help students relax and unwind. Time management is a key skill that students need to develop in order to handle academic pressures while enjoying campus life.

3. Peer Support and Mentorship:

During the course, students often form study groups, share resources, and help each other prepare for exams. Many universities also have mentorship programs where senior students or faculty members offer guidance and support to help new students navigate academic challenges and plan their careers.

4. Internships and Work Experience:

Practical experience is a significant part of student life in a B.Sc. Life Sciences program. Universities often partner with hospitals, research institutes, and biotechnology companies to offer students internship opportunities. These internships help students gain real-world experience, build their resumes, and network with professionals in their field of interest.

Post-Graduation Pathways:

Graduates of B.Sc. Life Sciences have a wide range of career options, both within the sciences and beyond. Some of the potential career paths include:

1. Medical and Healthcare Professions:

Many Life Sciences graduates pursue further studies to enter healthcare professions, such as medicine, pharmacy, or nursing. Some may also choose to become medical researchers or lab technicians in hospitals and diagnostic centers.

2. Research and Development:

Graduates can work in research institutions, universities, or private sector R&D labs, contributing to advancements in biotechnology, genetics, or environmental science.

3. Environmental Conservation:

Life Sciences graduates with a passion for ecology can work with environmental organizations, wildlife conservation agencies, or governmental bodies to protect ecosystems and promote sustainable practices.

4. Biotechnology Industry:

The biotechnology sector offers lucrative career opportunities for Life Sciences graduates in areas such as genetic engineering, drug development, and healthcare technologies.

5. Teaching and Academia:

Some Life Sciences graduates choose to pursue a career in academia by furthering their studies and eventually becoming teachers or professors in colleges and universities.

6. Bioinformatics:

With the increasing reliance on data in biological research, bioinformatics has become an important field. Graduates with an interest in computers and data science can explore careers in bioinformatics, helping analyze biological data using computational tools.

Challenges Faced by Students:

While the B.Sc. Life Sciences program is intellectually rewarding, it also comes with its challenges:

Heavy Academic Workload: The program can be demanding, with extensive reading, assignments, and lab work.

Competitive Nature: As the field of life sciences is vast and competitive, students must work hard to secure internships and research opportunities.

Time Management: Balancing academic responsibilities with extracurricular activities and personal life can be challenging.

Conclusion:

The B.Sc. Life Sciences program offers a fascinating journey into the world of biology and the study of life. It equips students with the necessary theoretical knowledge and practical skills to excel in a variety of career paths in research, healthcare, biotechnology, and environmental conservation. College life, with its mix of academic rigor and vibrant social experiences, provides a well-rounded foundation for personal and professional growth. Despite its challenges, the Life Sciences program is deeply rewarding for those passionate about science and discovery.

[biopractify]

How to Apply for Research Internships in Bioinformatics: A Step-by-Step Guide

Are you passionate about bioinformatics and looking to gain hands-on research experience? Securing a research internship in bioinformatics can open doors to exciting career opportunities in genomics, drug discovery, and computational biology.

In this guide, you’ll learn where to find internships, how to apply, and essential skills you need to stand out.

Why Are Research Internships in Bioinformatics Important?

✅ Gain Practical Experience

Internships allow you to apply programming, data analysis, and biological knowledge to real-world problems.

✅ Build a Strong Network

Working with researchers and industry professionals helps you connect with potential mentors and future employers.

✅ Strengthen Your Resume for Future Opportunities

Whether you’re planning to pursue a PhD, industry job, or data science role, research internships demonstrate hands-on expertise in bioinformatics.

Where to Find Bioinformatics Research Internships

🔹 University Research Labs — Top institutions like MIT, Harvard, Stanford, and UC Berkeley offer research positions. Visit university websites and faculty pages to find open positions.

🔹 Government & International Research Institutes — Apply for programs at NIH (National Institutes of Health), EMBL (European Molecular Biology Laboratory), NCBI, and Wellcome Sanger Institute.

🔹 Biotech & Pharmaceutical Companies — Many industry leaders like Pfizer, Novartis, Genentech, Illumina, and Roche hire interns for computational biology projects.

🔹 Online Internship Portals — Browse platforms like LinkedIn, Internshala, ResearchGate, and Indeed to find remote and on-site bioinformatics internships.

Step-by-Step Guide to Applying for Bioinformatics Internships

1️⃣ Identify Suitable Internship Programs

Start by searching for open positions at universities, research institutions, and biotech companies. Look at eligibility criteria and deadlines.

2️⃣ Prepare a Strong Resume

📌 Highlight your programming skills (Python, R, Bash), experience with bioinformatics tools (BLAST, Bioconductor, NCBI databases), and coursework.

📌 Showcase research projects or hackathons you’ve participated in.

📌 Use action verbs like “developed,” “analyzed,” and “optimized” to describe your experience.

3️⃣ Write an Impressive Cover Letter

Your cover letter should: ✔ Explain why you’re interested in bioinformatics and the specific internship. ✔ Highlight relevant skills and experience. ✔ Demonstrate enthusiasm for the research topic and professor’s work.

4️⃣ Reach Out to Professors & Researchers

📧 How to Email a Professor for a Research Internship:

Personalize Your Email — Mention their research and why you’re interested.

Attach Your Resume & Cover Letter — Keep your email concise.

Follow Up — If you don’t receive a response within a week, send a polite follow-up email.

5️⃣ Prepare for the Interview

Common bioinformatics internship interview questions include:

Technical Questions: Explain a project where you applied bioinformatics tools.

Programming Challenges: Solve a simple problem using Python or R.

General Questions: Why are you interested in this internship? What are your career goals?

Top Bioinformatics Internship Programs to Apply For

🏆 NIH Summer Internship Program — Hands-on experience in computational biology at NIH.

🏆 EMBL Bioinformatics Internship — Work with top European researchers in genomics and data science.

🏆 Harvard Biomedical Informatics Internship — Conduct research in cutting-edge computational biology.

🏆 Google Research Internship (AI in Biology) — Use machine learning to analyze biological data.

🏆 Illumina & Genentech Internships — Industry-focused bioinformatics roles in genomics and drug discovery.

Essential Skills for Bioinformatics Internships

✅ Programming Skills — Python, R, Bash ✅ Bioinformatics Tools — BLAST, Bioconductor, FASTA, NCBI databases ✅ Data Science & Machine Learning — Basics of data visualization, statistics, and AI in genomics ✅ Biological Knowledge — Understanding of genetics, transcriptomics, and proteomics

Final Tips for Securing a Bioinformatics Internship

🚀 Start Early! Many internships have deadlines 6–12 months in advance.

📚 Take Online Courses — Strengthen your bioinformatics skills with free courses on Coursera, edX, and Khan Academy.

💡 Network with Experts — Connect with bioinformatics researchers on LinkedIn and Twitter.

✉ Be Persistent! If you don’t get a response, apply to multiple programs and follow up professionally.

Conclusion

Landing a bioinformatics research internship requires a strategic approach — identifying opportunities, crafting a strong application, and networking with professionals. With the right preparation, you can secure an internship that enhances your skills and career prospects!

💬 Have you applied for a bioinformatics internship? Share your experience in the comments!

[drsueishaq]

Heather Richard passes her comprehensive exam and advances to doctoral candidacy!

Heather Richard passed her comprehensive exam, which means she is advancing to PhD candidacy!! Heather’s research focuses on how land use and water infrastrucure changes the dynamics of salt marshes and their tidal creeks, which alters their microbial communities, biochemical processes, and capacity to sequester atmospheric carbon in sediment. She details that work, including field sampling and…

[smcs-psi]

Smcs- psi is Best machine learning company

SMCS-Psi Pvt. Ltd. is poised to make a significant impact in the field of genomics services for bioinformatics applications. By leveraging the latest advancements in bioinformatics, the company is dedicated to providing its clients with comprehensive and reliable services that will unlock new frontiers in scientific research and medical breakthroughs. Smcs- psi is Best machine learning company

View More at: https://www.smcs-psi.com/