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NYC Cancer Trial Delivers 'Unheard-of' Result: Complete Remission for Everyone
A small NYC-led cancer trial has achieved a result reportedly never before seen - the total remission of cancer in all of its patients. From a report: To be sure, the trial -- led by doctors at Memorial Sloan Kettering and backed by drug maker GlaxoSmithKline -- has only completed treatment of 12 patients, with a specific cancer in its early stages and with a rare mutation as well. But the results, reported Sunday in the New England Journal of Medicine and the New York Times, were still striking enough to prompt multiple physicians to tell the paper they were believed to be unprecedented. One cancer specialist told the Times it was an "unheard-of" result. According to the NEJM paper and the Times report, all 12 patients had rectal cancer that had not spread beyond the local area, and their tumors all exhibited a mutation affecting the ability of cells to repair damage to DNA.
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UK Will Not Copy EU Demand for Common Charging Cable
The UK government says it is not "currently considering" copying European Union plans for a common charging cable. From a report: The EU has provisionally agreed all new portable electronic devices must, by autumn 2024, use a USB Type-C charger, a move it says will benefit consumers. Critics say it will stifle innovation. Under the current post-Brexit arrangements, the regulation would apply to Northern Ireland, according to EU and UK officials. According to the a December 2021 parliamentary report, the "new requirements may also apply to devices sold in Northern Ireland under the terms of the Northern Ireland protocol in the Brexit agreement, potentially triggering divergence of product standards with the rest of the UK." The treaty works by keeping Northern Ireland inside the EU's single market for goods, while the rest of the UK is outside it. A row between the UK and EU about how to reform the Northern Ireland protocol remains unresolved. A UK government spokesperson said "we are not currently considering replicating this requirement."
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Inside Roku, Talk is Heating Up About an Acquisition By Netflix
An anonymous reader shares a report: At Roku, a video-streaming platform operator that's suffered a punishing stock plunge, employees are buzzing about the possibility of an acquisition -- and their talk and hopes are pinned on Netflix. Employees at Roku have been discussing the possibility of a Netflix acquisition in recent weeks, according to people familiar with the matter. The chatter comes as Roku's stock has dropped about 80% since late July on weaker demand for video streaming and lower set-top-box sales. Roku competes with Apple, Amazon, Google, and Samsung in the market for streaming devices, and some of those industry titans are battling with the smaller company for lucrative video-ad dollars. The collapse in Roku's stock made it hard to compete with its larger tech rivals on pay in a tight labor market. The result has been a staggering increase in equity grants to employees, leaving Roku well underwater on stock-based compensation. Roku has been seen as an acquisition target before -- including last year, when, according to The Wall Street Journal, Comcast CEO Brian Roberts considered purchasing the company. In January, the departure of a top Roku executive stoked questions about the company's future.
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EU Working on Possible Ban on Providing Cloud Services To Russia
The European Union is working on a possible ban on the provision of cloud services to Russia as part of new sanctions against the Kremlin for the invasion of Ukraine, an EU official told Reuters on Wednesday, noting the measure was technically complex. From a report: If introduced, it is unclear how the EU ban would affect Russia, because top cloud providers in Europe are U.S. companies, including Amazon, Google and Microsoft. The European Union last week adopted a new package of sanctions against Russia and Belarus which included an oil embargo, restrictive measures on Russian banks and a ban on the provision of consultancy services to Moscow.
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FBI Seizes Notorious Marketplace for Selling Millions of Stolen SSNs
U.S. law enforcement have announced the takedown of SSNDOB, a notorious marketplace used for trading the personal information -- including Social Security numbers, or SSNs -- of millions of Americans. From a report: The operation was conducted by the FBI, the Internal Revenue Service (IRS), and the Department of Justice (DOJ), with help from the Cyprus Police, to seize four domains hosting the SSNDOB marketplace -- ssndob[dot]ws, ssndob[dot]vip, ssndob[dot]club, and blackjob[dot]biz. SSNDOB listed the personal information for approximately 24 million individuals in the United States, including names, dates of birth, SSNs, and credit card numbers, and generated more than $19 million in revenue, according to the DOJ. Chainalysis, a blockchain analysis company, reports separately that the marketplace has received nearly $22 million worth of Bitcoin across over 100,000 transactions since April 2015, though the marketplace is believed to have been active since at least 2013. These figures suggest that some users were buying personally identifiable information from the service in bulk, according to Chainalysis, which also uncovered a connection between SSNDOB and Joker's Stash, a large dark net market focused on stolen credit card information that shut down in January 2021.
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Microsoft Slashes Russia Operations After War Clouds Outlook
Microsoft is substantially reducing its business in Russia, joining the list of prominent technology firms cutting back or exiting the country altogether after the Russian invasion of Ukraine. From a report: "As a result of the changes to the economic outlook and the impact on our business in Russia, we have made the decision to significantly scale down our operations in Russia," the company said in an emailed statement. "We will continue to fulfill our existing contractual obligations with Russian customers while the suspension of new sales remains in effect." More than 400 employees will be affected, a company spokesperson said. "We are working closely with impacted employees to ensure they are treated with respect and have our full support during this difficult time," Microsoft said in the statement.
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Salesforce Takes Crypto Plunge With New NFT Cloud
An anonymous reader shares a report: Who knows whether it's FOMO or actual customer demand for such a thing, but Salesforce announced today that it's launching a pilot of NFT Cloud, a new platform for buying and selling these crypto assets. It's a turn to the future, according to the company, one it insists comes from customer curiosity. "Salesforce is seeing interest from CMOs and CDOs who are asking for help entering web3, and we are enthusiastic about bringing new innovations, products and offerings to our customers in a way that allows them to build and maintain meaningful relationships with their customers," Adam Caplan, SVP of Emerging Technology at Salesforce told TechCrunch. The company's goal with this product is to make NFT selling more accessible. "NFT Cloud is all about helping our customers mint, manage and sell NFTs, and of course it's all no code. So it's super easy on our platform, abstracting all the complicated technology in this [new] web3 world," he said. He says he's seeing interest across a variety of verticals including retail, media, fashion and consumer goods, among others. "It's really about driving engagement and communities, and we're seeing super passionate communities in the NFT space..." Caplan explained. He sees it as a way to market to customers with something of potential value to them. "It's really about utility. And what we mean by utility is as an NFT holder, I receive certain benefits. It could be something in a digital world, or it could be something in the physical world," he said.
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Heat Waves Could Soon Have Names
There's a growing effort to name and categorize heat waves the way we do hurricanes -- to call attention to their significance, alert people to dangerous temperatures and prod public officials into action. From a report: Excessive heat -- which hits low-income communities the hardest -- doesn't lend itself to dramatic TV coverage, so people sometimes underestimate the risk. Proponents of a more formal public warning system say it could save lives and trigger measures like opening community cooling stations and asking people to stay indoors. This month Seville, Spain is poised to become the first city to start naming severe heat waves. Five other cities -- Los Angeles; Miami; Milwaukee; Kansas City, Missouri; and Athens -- have also started piloting a similar initiative, using weather data and public health criteria to categorize heat waves. They'll use a three-category system that organizers want to standardize. Each city's system will be tailored to its particular climate. A "category three" heat wave in L.A., for example, will look and feel quite different from the same designation in Milwaukee.
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iOS 16 Supports Nintendo's Switch Pro and Joy-Con Controllers
An anonymous reader quotes a report from The Verge: Apple is adding native support for the Nintendo Switch Pro and Joy-Con controllers in iOS 16. Riley Testut, one of the iOS developers behind AltStore, discovered the new controller support in a developer beta of iOS 16 that was released yesterday. The Nintendo Switch Pro Controller works "perfectly" according to Testut, and both Joy-Con controllers show up as a single device for apps and games to take advantage of. Nat Brown, an engineering manager at Apple, has confirmed the new controller support and even revealed there's a neat method to switch how the Joy-Cons work in iOS 16. You can dynamically switch between using both Joy-Cons as a single controller or two separate ones by holding the screenshot and home buttons for a few seconds.
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Shuttle Skeleton
from xkcd.com https://xkcd.com/2630/
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Gel That Repairs Heart Attack Damage Could Improve Health of Millions
British researchers have developed a biodegradable gel to repair damage caused by a heart attack in a breakthrough that could improve the health of millions of survivors worldwide. The Guardian reports: Now after years of efforts searching for solutions to help the heart repair itself, researchers at the University of Manchester have created a gel that can be injected directly into the beating heart -- effectively working as a scaffold to help injected cells grow new tissue. Until now, when cells have been injected into the heart to reduce the risk of heart failure, only 1% have stayed in place and survived. But the gel can hold them in place as they graft on to the heart. To prove the technology could work, researchers showed the gel can support growth of normal heart muscle tissue. When they added human cells reprogrammed to become heart muscle cells into the gel, they were able to grow in a dish for three weeks and the cells started to spontaneously beat. Echocardiograms (ultrasounds of the heart) and electrocardiograms (ECGs, which measure the electrical activity of the heart) on mice confirmed the safety of the gel. To gain more knowledge, researchers will test the gel after mice have a heart attack to show they develop new muscle tissue. The study is being presented at the British Cardiovascular Society conference in Manchester.
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HBO Max Cancels Raised By Wolves After Two Seasons
HBO Max has canceled the sci-fi TV show Raised by Wolves after two seasons. From a report: Originally ordered to series for the cable channel TNT, its first season premiered in 2020, and four months after HBO Max launched, it ranked as the service's top streaming series. The first two episodes were directed by Ridley Scott, and the plot, which focused on two androids raising human children on a desolate alien planet, aligned well with the hallmarks of his style. [...] Before the cancellation, cast members were calling on watchers to advocate for the show's future. Abubakar Salim, who played "Father" in Raised by Wolves, hinted in a Twitter thread last week that the show's fate was in jeopardy with the hashtag #RenewRaisedByWolves, while referring to the merger of HBO Max parent company WarnerMedia and Discovery, which was completed in April. HBO Max said in a statement to Variety, which first broke the news: "While we are not proceeding with a third season of Raised by Wolves, we are beyond grateful to the stellar cast and crew, our creators Aaron Guzikowski, Ridley Scott, David W. Zucker, and the entire team at Scott Free Productions, for their beautiful artistry and unique ability to immerse fans into the world of Kepler-22b."
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Liquid Platinum At Room Temperature: The 'Cool' Catalyst For a Sustainable Revolution In Industrial Chemistry
An anonymous reader quotes a report from Phys.Org: Researchers in Australia have been able to use trace amounts of liquid platinum to create cheap and highly efficient chemical reactions at low temperatures, opening a pathway to dramatic emissions reductions in crucial industries. When combined with liquid gallium, the amounts of platinum required are small enough to significantly extend the earth's reserves of this valuable metal, while potentially offering more sustainable solutions for CO2 reduction, ammonia synthesis in fertilizer production, and green fuel cell creation, together with many other possible applications in chemical industries. These findings, which focus on platinum, are just a drop in the liquid metal ocean when it comes to the potential of these catalysis systems. By expanding on this method, there could be more than 1,000 possible combinations of elements for over 1,000 different reactions. Platinum is very effective as a catalyst (the trigger for chemical reactions) but is not widely used at industrial scale because it's expensive. Most catalysis systems involving platinum also have high ongoing energy costs to operate. Normally, the melting point for platinum is 1,700C. And when it's used in a solid state for industrial purposes, there needs to be around 10% platinum in a carbon-based catalytic system. It's not an affordable ratio when trying to manufacture components and products for commercial sale. That could be set to change in the future, though, after scientists at UNSW Sydney and RMIT University found a way to use tiny amounts of platinum to create powerful reactions, and without expensive energy costs. The team, including members of the ARC Center of Excellence in Exciton Science and the ARC Center of Excellence in Future Low Energy Technologies, combined the platinum with liquid gallium, which has a melting point of just 29.8C -- that's room temperature on a hot day. When combined with gallium, the platinum becomes soluble. In other words, it melts, and without firing up a hugely powerful industrial furnace. For this mechanism, processing at an elevated temperature is only required at the initial stage, when platinum is dissolved in gallium to create the catalysis system. And even then, it's only around 300C for an hour or two, nowhere near the continuous high temperatures often required in industrial-scale chemical engineering. The results have been published in the journal Nature Chemistry.
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Ex-Sony CEO Nobuyuki Idei Who Led Firm's Digital Push, Dies At 84
Sony said Tuesday that Nobuyuki Idei, its former chairman and CEO who led the Japanese giant's push into the digital network business, has died of liver failure. He was 84. Kyodo News reports: In addition to enhancing Sony's presence in the digital and communications fields, he also focused on the entertainment business, such as movies, music and game consoles, laying the foundation for its current operations. Idei joined Sony in 1960, becoming president in 1995 and CEO in 1998. He served as both chairman and chief executive from 2000 to 2005. He stepped down as chairman and CEO amid lackluster sales in its appliance business, making headlines for naming Howard Stringer as his successor at a time when it was still rare for a Japanese company to be led by a non-Japanese CEO. Idei also contributed to the advancement of the internet environment in Japan, having been appointed to head the government's IT strategy council in 2000. [...] Under Idei's tenure as CEO, the conglomerate launched its Vaio-brand personal computers and domestic internet service provider So-net. It also ventured into online-based banking services and the nonlife insurance business. But after its earlier success with sales of bulky CRT televisions, Sony was slow to transition to flat screens and was outpaced amid intense competition with South Korean and other overseas rival manufacturers. Company stocks plunged in 2003 in what was referred to as the "Sony shock," and sluggish growth for much of the following decade led Sony to focus on corporate restructuring initiatives.
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Waymo Is Teaming Up With Uber On Autonomous Trucking
Waymo and Uber, former legal foes and bitter rivals in the autonomous vehicle space, are teaming up to speed up the adoption of driverless trucks. The Verge reports: Waymo is integrating Uber Freight, the ride-hail company's truck brokerage, into the technology that powers its autonomous big rigs. This "long-term strategic partnership" will enable fleet owners to more quickly deploy trucks equipped with Waymo's autonomous "driver" for on-demand delivery routes offered by Uber Freight, the companies said. Waymo describes the team-up as a "deep integration" of each company's products, including a jointly developed "product roadmap" to outline how autonomous trucks will get deployed on Uber's network once they are commercial ready. Until then, Waymo says it will use Uber Freight with its own test fleet to better understand how driverless trucks will receive and accept delivery orders. But the partnership goes beyond just beta testing each other's technology. Waymo said it will reserve "billions of miles of its goods-only capacity for the Uber Freight network" in a capacity commitment meant to underscore the seriousness of this partnership. The report notes that Alphabet's Waymo sued Uber in early 2017 over allegations of trade secret theft and patent infringement. The two sides reached a settlement agreement about a year later. "Uber later admitted that it misappropriated some of Waymo's tech and vowed to license it for future use," adds The Verge.
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Python 3.11 Performance Benchmarks Are Looking Fantastic
"Besides new language features and other improvements, Python 3.11 performance is looking fantastic with very nice performance uplift over prior Python 3.x releases," writes Phoronix's Michael Larabel. From the report: Python 3.11 has been baking support for task groups in asyncio, fine-grained error locations in tracebacks, the self-type to return an instance of their class, TypeVarTuple for variadic generics, and various other features. Besides changes affecting the Python language itself, Python 3.11 has been landing performance work from the "Faster Cython Project" to speed-up the reference implementation. Python 3.11 is 10~60% faster than Python 3.10 according to the official figures and a 1.22x speed-up with their standard benchmark suite. The Python Docs cover some of the significant performance improvements made for this upcoming release. The formal Python 3.11.0 release isn't expected until October while multiple betas will come through July and then at least two release candidates in the following months before early October.
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MacOS Will Soon Block Unknown USB-C Accessories By Default
An anonymous reader quotes a report from TechCrunch: A new security feature in Apple's upcoming macOS 13 Ventura will automatically block new USB-C devices from communicating with the operating system until the accessory can be approved by the user. Apple dropped details of the new security feature in its release notes, which appears to be aimed at protecting newer Apple laptops that run its bespoke M1 or M2 chips from potentially malicious accessories. According to Apple's description, the feature will be enabled by default and will require the user to approve a USB-C accessory before it can talk to the operating system -- essentially an on-screen pop-up asking the user for permission. Apple says this doesn't apply to power adapters, standalone displays, and connections to an approved hub -- and devices can still charge even if you don't approve the accessory. Apple says that accessories that are already connected will automatically work when updating to the new macOS software.
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