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Scaling with Genizer: Homogenizers

At Genizer, we want our equipment to be with you every step of the way! That’s why we make equipment that squeezes into an academic lab all the way up to manufacturing. Here’s the High-Pressure Homogenization equipment that can take you all the way to capacity.

HandGenizer

For a more portable solution to high-pressure homogenization, we have the HandGenizer. Well suited to long-term storage, the HandGenizer is great in an academic R&D context. Its’ distinctive manual option and compact size set the HandGenizer apart, though it is best suited to small, even solutions like nanoemulsions.

NanoGenizer

Next is the NanoGenizer. Our most popular model, the NanoGenizer fits easily in a benchtop with a length under 28 inches (70 cm). The Nanogenizer has a max flow of 100mL/min, and a max pressure of 45,000 psi. Ideal for R&D, laboratory, and small-scale production. The NanoGenizer is quiet and easy to use. It also comes in Dual and Quad options for additional capacity, and the NanoGenizer and all larger units have a MixGenizer option, for in-chamber mixing.

UltraGenizer

Our half-step up from the NanoGenizer is the UltraGenizer. The UltraGenizer comes with the unique ability to reach 60,000 psi! At a pressure of 30kpsi, it can reach 25L/Hr. It also has a higher runtime of 4-6 hours, giving a much higher processing capacity.

PilotGenizer & ProdGenizer

WillNano

Finally, our WillNano ManuGenizer series is ideal for your manufacturing needs! The Willnano offers up to 4 pumps to reach your desired flow rate. At 30kpsi, these machines can reach up to 480L/hr. And if that still doesn’t meet your needs, there’s always more than one.

We also offer many sanitary certifications and IQ/OQ documentation. With our scalable options, we know you can find the right size with Genizer!

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NanoGenizer Lab Homogenizer for Cell Disruption NanoGenizer High Pressure Homogenizer for Nanomaterials NanoGenizer, a lab-scale microfluidic high pressure homogenizer, offers effective performance on particle size reduction and cell disruption. It utilizes interaction high-pressure microfluidic jet technology, and equipped with highly modular power and processing units. NanoGenizer is suitable for rare and valuable samples because of its minimum dead volume design and its continuous flow rate, which enables it to process up to 120 mL/min. With successful applications in various nanotechnology settings, the NanoGenizer has gained increasing recognition due to its notable shear rate, excellent repeatability, and guaranteed scalability.   NanoGenizer provides efficient solutions for various nanomaterials, including: liposomes, nano-emulsions, nano-crystals, micelles, lipid nanoparticles, cosmetic nano-encapsulation materials, nano-particle dispersion, graphene, carbon nanotube, and more. As more organizations recognize this, NanoGenizer is becoming an essential high pressure homogenizer for laboratories working on high-end nanomaterial preparation.

Core Technology: Interaction Chamber with Microfluidic Jet NanoGenizer can be divided into a power unit (including the power system, control system, and high-pressure pump system) and a processing unit (including the microfluidic diamond interaction chamber, material inlet and outlet, and heat exchanger). The diamond interaction chamber is a reaction component with a specially-designed fix geometry, where high pressure, high speed micro-jets occur and samples are processed. After being pressurized and accelerated by the intensifier, the sample’s micro-jet can reach speeds of 1,000 m/s, faster than the speed of sound (340 m/s). When the high-speed bullet-type micro-jet passes through the diamond interaction chamber’s micro-channels, it undergoes complex physical effects, such as high-frequency shearing, high-energy impact, cavitation and pressure drop, and more. After that, the material is homogenized and nano-sized.   The diamond interaction chamber is the core area where the high-speed micro-jet, high-shear, high-energy collision, and other effects occur. It has fixed Y- or Z-shaped diamond micro-channels inside, which guarantees a consistent effect: accurate and repeatable particle size distribution.

Features of the NanoGenizer High Pressure Homogenizer High Shear Rate After being pressurized by the power unit, the liquid or solid-liquid mixture sample’s micro-jet can reach speeds up to 1,000 m/s inside the diamond interaction chamber (DIXC). The minimum dimension of the inside of the DIXC can be as small as 50 μm. As shown in Figure 4, the NanoGenizer’s shear rate is the highest among comparable technologies.

The NanoGenizer high pressure homogenizer’s shearing force on the material is unmatched by conventional homogenizers or other homogenizing equipment.   Fixed Internal Structure and Consistent Reaction Pressure

The diamond interaction chamber has a fixed internal shape (Figures 5 and 6) and does not move with pressure changes. When the sample passes through the DIXC, the applied pressure is at a constant peak during each cycle’s process (see the blue curve in Figure 7). However, the traditional homogenizing valve has a dynamically adjustable structure. The pressure of the material changes dynamically when it passes through a conventional homogenizer’s valve, which operates at peak pressures for mere moments of each cycle (the black curve in Figure 7). The particle size of the material processed by the microfluidic diamond interaction chamber is reduced efficiently, and the distribution is more uniform than can be achieved with a traditional homogenizing valve.

Interaction Effect The design of the Y-type DIXC takes full advantage of the interaction collision of the materials themselves. The instantaneous relative velocity of the two jets is doubled, resulting in an explosion effect. The collision between the materials greatly reduces the materials’ wear and shear to the interaction chamber, prolonging the chamber’s service life and avoiding the risk of stainless steel particles falling off.  The patented DIXC-RT with cooling function (see Figure 3) protects the bioactivity of the samples.   Guaranteed Scalability 

The single-slotted DIXC (shown in Figure 2 and Figure 3) is suitable for lab-scale high pressure homogenization equipment. The multi-slotted DIXC (shown in Figure 8 and Figure 9) is composed of multiple diamond micro-channels copied in parallel, ensuring the treatment effect’s consistency. The increased number of channels also allows for larger volumetric flow rate.   Genizer LLC is one of two companies in the world that supplies high pressure homogenizers equipped with original microfluidic diamond interaction chambers. In recent years, Genizer’s microfluidic diamond interaction chambers have been equipped by more and more homogenizer manufacturer.   Easy to Operate and Intelligent The highly modular and integrated control design of NanoGenizer makes it extremely simple to install and operate. Operators can complete routine operations by clicking the three buttons—"pressure rate,” “start,” and “stop”—on the touch screen. Customers find the equipment simple to operate: They only need to set a pressure on the screen and then click to start or stop. There is no need to screw the valve forcefully or waste any sample to adjust the pressure. To process a particularly small volume, you can set the sample volume processed by one stroke, the stroke cycle times, and the automatic stop time on the setup interface. Compared with other high pressure equipment, the NanoGenizer’s operation is elegant and efficient.

Small Minimum Sample NanoGenizer’s highly modular design enables simple installation and maintenance. The dead volume is no more than 1 mL, far below the dead volume of other high pressure homogenizers, which is typically more than 10 mL. Therefore, when a 10 mL sample is processed in traditional homogenizers, it is almost impossible get product from the outlet. NanoGenizer's modular pipeline design can achieve a minimum single processing volume of 5 mL by setting the volume autonomously, making it the best equipment option for preparing and developing rare, costly samples. NanoGenizer’s continuous flow rate is 7 L/h, suitable for conventional small batches.   Software and Hardware Options Temperature Control: Jacketed interaction Chamber; jacketed inlet cylinder; 3D heat exchanger Suspension Preparation: Hollow magnetic stirrer Corrosion Resistance: Titanium cylinder option Precision Sampling: Precision sampling as accurate as 0.1 mL (e.g., 10.0mL, 10.1mL, and 10.2mL sampling are all possible) Ports: Data log, USB port, and multi-sensor ports for temperature and pressure     Scientific researchers who have used NanoGenizer are impressed by its high processing efficiency, easy operation, and intelligent control. NanoGenizer is currently the one of the most selected homogenizers for nanomaterials in the world.

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Genizer, located in Technology Link in Greater Los Angeles, is dedicated to advancing homogenizer nanotechnology. We provide high pressure homogenizers, liposome extruders, sanitary heat exchangers, diamond interaction chambers, and high pressure gauges compatible with other brands of high pressure homogenizers and high pressure pumps.

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The NanoGenizer | A High-Pressure Homogenizer for Laboratory Settings

The NanoGenizer is the most popular unit from Genizer. This high-pressure homogenizer is perfect for laboratory settings because of its compact and energy efficient design.  The NanoGenizer is simple to use. It plugs into the wall and has a convenient touch screen with an auto-stop function. The body of the NanoGenizer serves as the engine to power the ceramic piston. The sample travels in through the inlet valve and out the outlet valve into the diamond interaction chamber (DIXC).

The DIXC can be either Y-shaped or Z-shaped. In the Y-shaped interaction chamber, the sample separates into two streams. The streams turn at a 90° angle and collide with each other. Where the two streams collide, forces like high shear and cavitation homogenize the sample. While in the Y-shaped interaction chamber the sample collides with itself, in the Z-shaped chamber the sample collides with the wall of the chamber. In addition to the cooling function in the interaction chambers, Genizer offers a real-time cooling system, with the heat exchanger. This feature is useful for thermally unstable samples. Common applications for the NanoGenizer include but are not limited to nanoemulsions, cell disruption and deagglomeration.

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Homogenizers play a crucial role in various industries, including pharmaceuticals, cosmetics, food and beverage, and biotechnology. These machines are used to create uniform mixtures of two or more immiscible liquids or to reduce particle size, resulting in stable and high-quality products. In the upcoming sections, we will explore the various types of homogenizers and their uses. Mechanical Homogenizers

Mechanical homogenizers use mechanical force to break down particles and droplets in a mixture, resulting in a homogeneous solution. There are several subtypes of mechanical homogenizers:

a. Rotor-stator homogenizers: These devices use a high-speed rotating component to generate shear forces that break down particles. They are suitable for applications such as emulsification, dispersion, and cell disruption. Rotor-stator homogenizers are often used in the pharmaceutical, cosmetic, and food industries.

b. Ultrasonic homogenizers: Ultrasonic homogenizers use high-frequency sound waves to create cavitation, breaking down particles and droplets. This technology is suitable for applications like cell disruption, emulsification, and dispersion. Ultrasonic homogenizers are often used in the biotechnology and nanotechnology industries.

c. Bead mill homogenizers: Bead mill homogenizers utilize small beads or grinding media to mechanically break down particles. They are commonly employed for applications such as nanoparticle production, cell disruption, and pigment dispersion. Bead mill homogenizers are often used in the pharmaceutical, cosmetic, and paint industries.

Pressure Homogenizers Pressure homogenizers use high pressure to force a mixture through a narrow gap or orifice, causing the particles to break down due to shear forces. They are particularly effective in producing fine emulsions and dispersions. The two main types of pressure homogenizers are high pressure homogenizers and microfluidizer homogenizers.

a. High pressure homogenizers: These homogenizers are widely used in the pharmaceutical, cosmetic, and food industries because of their ability to produce highly stable emulsions and dispersions with small particle sizes. High pressure homogenizers work by forcing a liquid mixture through a narrow gap at high pressure, exposing the particles and droplets to intense shear forces and turbulence, which results in the reduction of particle size and the formation of a homogeneous mixture.

b. High Pressure Microfluidizer homogenizers: Microfluidizer homogenizers, such as the Genizer Homogenizers, are a type of high-pressure homogenizer that uses a fixed-geometry interaction chamber to achieve consistent particle size reduction and distribution. They are suitable for applications such as cell disruption, emulsification, and nanoparticle production. Microfluidizer homogenizers are often used in the pharmaceutical, biotechnology, and nanotechnology industries.

Genizer Homogenizers are a leading brand of microfluidizer homogenizers, known for their efficiency, reliability, and versatility. These high-pressure homogenizers use a unique microfluidics technology to produce highly stable and uniform emulsions, dispersions, and suspensions. Key advantages of Genizer Homogenizers include: Consistent results: Genizer Homogenizers utilize a fixed-geometry interaction chamber, ensuring consistent particle size reduction and distribution across different batches.

Scalability: Genizer Homogenizers are designed to meet the needs of various scales, from laboratory research to industrial production.

Wide range of applications: Genizer Homogenizers are suitable for a diverse range of applications, including cell disruption, emulsification, and nanoparticle production.

Easy to use and maintain: Genizer Homogenizers are designed with user-friendly interfaces and require minimal maintenance, making them a popular choice for researchers and industry professionals. Conclusion Understanding the different types of homogenizers and their applications is essential for selecting the right equipment for your specific needs. High pressure microfluidizer homogenizers, such as Genizer Homogenizers, offer unique advantages in terms of consistency, scalability, and versatility, making them an ideal choice for various applications in the pharmaceutical, biotechnology, and nanotechnology industries. By exploring the technologies and applications of various homogenizers, you can make an informed decision and optimize your processes for enhanced efficiency and product quality.

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3 Questions to Choose a Liposome Extruder

3 Questions to Ask While Looking for a Liposome Extrusion Option

There are three questions to ask when you are choosing a liposome extrusion option. First, what pore size do you need? While a solo homogenizer reaches a liposome size of 20-30nm, any option with extrusion allows for more choice.

Second, what power types do you have access to? The jacketed liposome extruders allow for gas power. An electric option is available if you go for a high-pressure homogenizer with or without an extruder. And manual options are available in the HandExtruder and HandGenizer.

Third, what scale of sample do you need to process? Genizer makes extrusion options from 1 mL to manufacturing scale.

There are advantages coming from the various options as well to help you make your choice! Reach out at la@genizer.com for more information.

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The advantage of Genizer liposome extruders

Genizer offers a comprehensive range of extruders suitable for researchers and manufacturers across all scales, from lab-scale HandExtruder and GJE-10mL/100mL models for small-scale research and development, to pilot-scale GJE-800mL/3000mL models for larger experiments and production runs, and the GOE-8L/25L extruder for large-scale commercial production. This means that regardless of the scale of the project, Genizer has an extruder that can meet the requirements.

Genizer extruders can be easily connected to its own high-pressure homogenizers to create a powerful, integrated system. The intelligent control system of the homogenizers allows researchers and manufacturers to effortlessly set and adjust parameters, which enables precise control over critical factors such as temperature, pressure, and flow rate.  By ensuring that the processes are efficient and accurate, the intelligent control system of the homogenizers results in consistent, high-quality liposomes. This integration also saves time, reduces the risk of contamination, and enables greater control over the final product.

Genizer extruders are designed to meet strict pharmaceutical requirements and have been adopted by leading pharmaceutical companies worldwide, including Sanofi, Teva Pharma, GP Pharma and so on. These industry leaders have put Genizer's extruders to the test, and the results have been overwhelmingly positive. Genizer's extruders have received unanimous acclaim from these industry leaders for their reliability, precision, and efficiency and have become the go-to choice for pharmaceutical researchers and manufacturers worldwide.

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Liposome Processing: High-Pressure Homogenizer or Liposome Extruder?Choosing between a high-pressure homogenizer or a liposome extruder for your liposomes can be complicated. Both devices can process liposomes, but there advantages to each that will help you decide which is better for your application.

High-Pressure Homogenizer Power: Powering the NanoGenizer high-pressure homogenizer is simple. It’s electrically powered, and all you have to do is plug it into the wall. Speed: The NanoGenizer has a faster flow rate than a liposome extruder. Efficiency: While jamming occasionally happens with a liposome extruder, the NanoGenizer will not jam.

Accuracy: The jacketed liposome extruders have a narrower size distribution of liposomes after processing.

Adjustable: With a liposome extruder, you can adjust the mambrane pore size and determine the diameter of liposmes after rpces.

Economical: Our liposome extruders are more affordable than high-pressure homogenizers. Power: Our jacketed liposome extruders are gas powered.

Using a liposome extruder connected to a high-pressure homogenizer allows you to gain advantages from both. It is fast, precise, unlikely to jam, allows you to determine pore size and is powered using only electricity.

Reach out to our team learn more about how to process your liposomes at la@genizer.com

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5 Advantages of High-Pressure Homogenization for Cell Disruption

Powerful

High-pressure homogenization can be used to break apart stubborn cells more quickly, for instance by reducing the number of passes required to disrupt the cells. Link

With high-pressure homogenization, you can scale from the R&D lab scale all the way up to a manufacturing setup.

Non-Chemical

With the use of high-pressure homogenization, you can avoid the use of chemicals that may compromise your desired result from cell disruption.

Multifunctional

A high-pressure homogenization is not a single function instrument. In fact, it can be used for a variety of purposes. For example, making nanoparticles, nano emulsions, or re-sizing liposomes.

To learn more about high-pressure homogenization, reach out to our team at info@genizer.com!

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HandExtruder| How Does A Liposome Extruder Work?

A liposome extruder is used for nanoscale liposome formulation, to obtain a unifo rm size distribution, and to prepare exosomes and artificial cell membranes.

HandExtruder

The HandExtruder works with manual power, meaning you can operate it using only your hands. Simply push a liposome suspension through the extruder. This forces the sample through a membrane filter with a defined pore size and makes your liposome suspension become the pore size. You may need to run a sample through the extruder more than once through the same membrane pore size, or through progressively smaller pore sizes, to reach your desired result. You can also use a high-pressure homogenizer to accelerate the process before using a liposome extruder.

Components

The HandExtruder handles experimental volumes from 0.25mL to 2.5 mL, and a cooling jacket option is available for temperature control.

Applications

While a high-pressure homogenizer can perform liposome formulation, the liposome extruder is lower cost and has a narrower size distribution of liposomes after processing. Liposome extruders are used for research and development for liposomal drug delivery systems, vaccines, gene delivery, cosmetics and more.

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High shear mixing and high-pressure homogenization are both methods of particle size reduction, homogenization and emulsification. Both methods are based primarily on shear force. However, they have differing advantages and one or the other may be better suited based on your application.

What is shear force?

Shear force is any force parallel to a material’s surface. In a liquid, this results in friction between fluid particles, that can result in particle size reduction.

In high shear mixing, the shear force is generated through methods like high-speed blades or a rotor stator. In rotor stator, two pieces work together. The stator is stationary, and it sits around the rotating rotor to generate shear force.

High-pressure homogenization creates shear by propelling the sample through a narrow tube. For instance, the Y-shaped diamond interaction chamber splits the liquid sample in two and collides it with itself. The narrow section before collision generates shear. Homogenization also generates additional forces, like the impact from the samples colliding and cavitation.

Pros and Cons

High shear mixing has the capacity to handle larger volumes and more viscous samples than high-pressure homogenization. High shear mixing can be the more affordable option. However, high-pressure homogenization has a narrower distribution size, a smaller particle size, and is generally the more precise option.

High shear mixing can handle larger beginning particle size, while high-pressure homogenization can reach smaller ending particle sizes. This is one reason for some applications processing begins with high shear mixing or sonication and ends with high-pressure homogenization. This can reduce the starting particle size for high-pressure homogenization and reduce processing time.

High-pressure homogenization is typically faster processing, and results will be much more uniform. This is because all the sample goes through the same process, while in high shear mixing, processing for the sample differs based on the distance of each part of the sample from the blades or rotor stator.

Please contact our team at info@genizer.com to learn more about how high-pressure homogenization would work for you!

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The Difference of High-Pressure Homogenization vs. Sonication

Homogenization is a crucial step in various industrial processes, including pharmaceuticals, food, and cosmetics. High-pressure homogenization (HPH) and sonication are two common homogenization techniques, but HPH offers several distinct advantages over sonication, especially when used with Genizer's high-pressure homogenizers.

Smaller Particle Sizes

One of the most significant advantages of HPH over sonication is its ability to produce smaller particle sizes. HPH operates at much higher pressures and forces the sample through a narrow valve, resulting in a more intense and efficient homogenization process. This leads to smaller particle sizes, which can improve product quality, increase bioavailability, and enhance downstream processing steps such as filtration or extraction.

Scalability and Energy Efficiency

Another advantage of HPH over sonication is its scalability and energy efficiency. HPH systems can process larger volumes of material, making it a more efficient and cost-effective option for industrial-scale processing. Additionally, HPH is a more energy-efficient process than sonication, which can result in significant cost savings over time.

Gentler Processing Conditions

Finally, HPH can be a gentler process than sonication, particularly when processing delicate samples like pharmaceuticals or biologics. Sonication generates heat and cavitation, which can damage sensitive compounds and reduce product quality. In contrast, HPH provides more precise control over processing conditions, allowing for a gentler and more consistent homogenization process. When it comes to high-pressure homogenization, Genizer's high-pressure homogenizers are among the most reliable and efficient options in the market. With advanced technology and user-friendly designs, Genizer's homogenizers offer precise control over processing parameters, enabling efficient and gentle processing of various samples. In conclusion, while sonication can be a useful tool for processing samples, HPH offers several advantages over sonication, including smaller particle sizes, scalability, energy efficiency, and gentler processing conditions. By using Genizer's high-pressure homogenizers, these advantages can be maximized, making HPH a preferred choice for industrial-scale processing in various fields.

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Nanogenizer: The Ultimate Solution for Nanoparticle Production

Nanoparticles have become an important part of modern technology, playing a vital role in a wide range of fields, including medicine, energy, and electronics. However, the production of high-quality nanoparticles remains a challenge, making it difficult to take full advantage of their unique properties. To overcome this problem, Genizer has developed the Nanogenizer, a cutting-edge tool that makes nanoparticle production more efficient and accessible than ever before.  

The Nanogenizer is a compact and easy-to-use device that allows you to produce nanoparticles quickly and with a high degree of control. It uses a proprietary technology to create nanoparticles from a variety of materials, including metals, ceramics, and polymers. The resulting particles are highly uniform in size, shape, and composition, making them ideal for use in a wide range of applications.

One of the key-benefits of the Nanogenizer is its high-yield production. It produces nanoparticles in large quantities, making it ideal for industrial-scale applications. Furthermore, it is designed to be scalable, so you can easily increase the size of your nanoparticle production as your needs grow.  

Another advantage of the Nanogenizer is its user-friendly design. It is simple to operate, and its instinct interface makes it easy to fine-tune your nanoparticle production to meet your specific needs. Whether you're an experienced scientist or a beginner, you'll be able to use the Nanogenizer with ease.  

The Nanogenizer is also incredibly versatile. It can be used to produce nanoparticles with a wide range of sizes, from just a few nanometers to several microns. This makes it suitable for a wide range of applications, including drug delivery, energy storage, and catalysis.  

In conclusion, the Nanogenizer is the ultimate solution for anyone looking to produce high-quality nanoparticles quickly and efficiently. With its high-yield production, user-friendly design, and versatility, it's the perfect tool for scientists, engineers, and researchers alike. Whether you're working in a laboratory or an industrial setting, the Nanogenizer is sure to revolutionize the way you produce nanoparticles.

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How does the NanoGenizer Work | Core Processing Unit

The NanoGenizer is a laboratory scale high-pressure homogenizer. There are two segments of the NanoGenizer, the power unit and the core processing unit. The core processing unit is where homogenization occurs.

Before homogenization, the user places the sample in the inlet reservoir. Genizer offers a variety of options for your inlet reservoir. You may prefer a smaller or larger inlet reservoir depending upon the size of your sample. In addition to stainless steel, we offer plastic syringes and glass inlet reservoirs. Genizer also offers a variety of outlet reservoirs, where the sample goes after processing. You may prefer to use a jacketed glass cylinder, which you can connect to a laboratory chiller circulator for temperature controls. For small, valuable samples, the syringe option is best.

You can hook a Luer hose up to the outlet valve and place the other end in the inlet reservoir to circulate your sample through the core processing unit multiple times. Most samples need 5-10 passes through the diamond interaction chamber (DIXC) to be fully homogenized. Alternatively, you can place the Luer hose into any outlet receptacle in your lab.

The inlet and outlet valve ensures your sample travels the correct direction through the core processing unit. The inlet valve is a one-way valve that allows the sample to enter but not exit. The outlet valve is also a one-way valve and allows the sample to exit but not enter. The sample travels through the inlet valve, into the-high pressure cylinder, and out the outlet valve into the Diamond Interaction Chamber.The Diamond Interaction Chamber is where homogenization occurs. The chamber can be either Z-shaped or Y-shaped. In the Y-shaped diamond interaction chamber, the sample splits into two streams. Where the two streams collide, forces like high shear and cavitation homogenize the sample. In the z-type chamber, instead of the sample colliding with itself, it collides with the wall of the chamber. After homogenization, the particles are smaller and more uniform and liquids that would normally be immiscible can be mixed.

Genizer's Diamond Interaction Chamber can come with a cooling option. Additionally, if you need more cooling properties, Genizer offers a real-time heat exchanger. This method of cooling is superior for thermally unstable samples. The NanoGenizer offers low minimum volume, low dead volume and temperature control options. Please click here for more information on the NanoGenizer.

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Jacketed Liposome Extruder: Solutions for Nano

If you are working in pharmaceutical and gene development and delivery, there is a high chance you have at least heard of a liposome extruder. Genizer’s Jacketed Liposome Extruder is leading the industry in innovation and precision. 

Liposome extrusion is mainly done to formulate liposomes and achieve a uniform size distribution. Generating nanoscale liposome formulations, and preparing exosomes and artificial cell membranes are other processes that can be done with a liposome extruder.

There are many advantages to utilizing Genizer’s Jacketed Liposome Extruder.

Firstly, Genizer’s Jacketed Liposome Extruders are unique in that they have a built in  temperature control unit. Most of our jacketed liposome extruders are designed with jacketed barrels. With the ability to hook a cold water unit to its body, the jacketed liposome extruder can guarantee effective extrusion while working with samples that must maintain a certain temperature. This is particularly important when working with pharmaceuticals and genes because of their need to maintain bioavailability. 

Secondly, air-compression using a compressed nitrogen cylinder (or other gas chambers) is what drives the power behind jacketed liposome extruders. This ensures that the given pressure is enough to extrude samples through polycarbonate membranes.

Lastly, there is a wide range of processing capacities allowing Genizer’s Jacketed Liposome Extruders to work in a wide range of applications and industries. The different models of extruders that differ in sample volume size starting with 2mL and going up to 3L in volume. This makes the extruders suitable for laboratory scale use all the way up to pilot scale use. With the addition of Genizer’s Online Liposome Extruders, formulation can even occur on a production and manufacturing scale.

Genizer takes pride in their Jacketed Liposome Extruder’s abilities in various industry settings. With its temperature control, air-compression power, and wide range of applications, Genizer’s jacketed liposome extruder will produce nano-sized liposomes with impressive precision and accuracy.